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| 1 | Comparing the Diagnostic Criteria for Gestational Diabetes Mellitus of World Health Organization 2013 with 1999 in Chinese Population显示文摘INTRODUCTION Gestational diabetes mellitus (GDM) was earlier defined as 'hyperglycemia first recognized during pregnancy' and has more recently been described by American Diabetes Association (ADA) (2012) as diabetes diagnosed during pregnancy that is not clearly overt diabetes.[1] The hyperglycemia and adverse pregnancy outcomes study (HAPO) demonstrated that the risk of adverse maternal,fetal,and neonatal outcomes continuously increase as a function of maternal glycemia at 24-28 weeks,even within ranges previously considered normal for pregnancy.[2] After reviewing the results of the HAPO study,many international diabetes study groups,including the International Association of Diabetes and Pregnancy Study Groups and ADA have adopted the 75 g oral glucose tolerance test (OGTT) at 24-28 weeks as a screening and diagnostic test and defined new cut-off values for GDM diagnosis.The Ministry of Health of China published the criteria for GDM,that is the same as the ADA criteria on July 1,2011.World Health Organization (WHO) has recommended the 75 g OGTT with different cut-offvalues as a diagnostic test since 1999,changed its recommendation on 2013.In Hongkong and Yunnan province in China,most hospital adopted the WHO 1999 criteria,nevertheless,there is no evidence of multicenter and large sample to show that the GDM population within the same ethnic group diagnosed by the new WHO criteria matches those diagnosed by the old one and consistency between the two criteria has not been reported.Thus,we conducted this study to analyze the two criteria in Chinese pregnant women. | Weiwei Zhu Huixia Yang Yumei Wei Zilian Wang Xuelan Li Hairong Wu Nan Li Meihua Zhang Xinghui Liu Hua Zhang Yunhui Wang Jianmin Niu Yujie Gan Liruo Zhong Yunfeng Wang Anil Kapur | 2015 | Chinese Medical Journal2015，，1： | 42 |
| 2 | Vapor deposition of aluminium oxide into N-rich mesoporous carbon framework as a reversible sulfur host for lithium-sulfur battery cathode显示文摘Restraining the shuttle effects of lithium polysulfides is the key to improve the cycling reversibility and stability of lithium-sulfur(Li-S)batteries for which design of robust sulfur hosts has been regarded as the most effective strategy.In this work,we report a new type of hybrid sulfur host which is composed of Al_(2)O_(3) homogenously decorated in nitrogen-rich mesoporous carbon framework(NMC-Al_(2)O_(3)).The NMC-Al_(2)O_(3) hybrid host features a poly-dispersed spherical morphology and a mesoporous configuration with high surface area and large pore volume that can accommodate a high sulfur content up to 73.5 wt.%.As a result,the fabricated NMC-Al_(2)O_(3)-S cathode exhibits all-round improvements in electrochemical properties in term of capacities(1,212 mAh·g^(-1)at 0.2 C;755 mAh·g^(-1)at 2 C),cycling charge-discharge reversibility(sustainably 100%efficiencies)and stability(1,000 cycles with only 0.023%capacity decay per cycle at 0.5 C).By contrast,the Al_(2)O_(3)-free NMC-S cathode shows both decreased capacities and rapidly descending Coulombic efficiencies during cycling.Density functional theory(DFH')calculations further reveal that the implanted Al_(2)O_(3) can greatly enhance the chemical adsorption and catalytic conversion for various lithium polysulfides and thereby effectively prevent the polysulfide shuttling and significantly improve the utilizability,reversibility and stability of sulfur cathode. | Fei Sun Zhibin Qu Hua Wang Xiaoyan Liu Tong Pei Rui Han Jihui Gao Guangbo Zhao Yunfeng Lu | 2021 | Nano Research2021，14，1： | 3 |
| 3 | Identification of two antigenic epitopes on SARS-CoV spike protein显示文摘 | Ronghong Hua Yanjun Zhou Yunfeng Wang | 2004 | Biochemical and Biophysical Research Communications2004，319，： | 1 |
| 4 | Coastal Environmental Changes and Management in China in the Context of Global Changes and Human Activities显示文摘Coastal zone is the complex area with intense sea-land interaction. There are various types, complex environments and developed economy in coastal area of China. Under the influence of global change and human activities, the ecosystem of coastal zone is vulnerable and has sensitive response to environment changes. The environmental problems of sea-level rising have attached close attention by countries all over the world. As far as regions concerned, relative sea-level rising is more important than theoretical sea-level rising. The relative sea-level rising has resulted in series of environment disasters in coastal area of China, such as coastal erosion, seawater invasion, and floods in coastal lowlands, etc. The flux of sediments transported by rivers into sea is the main material source of marine pollution. The human activities are controlling factors of variations in river sediment loads. Under the influence of high strength development in the upstream region, the results are that the reduction of seagoing sediments in main rivers of China, and damage of coastal material balance. Land-based pollution is the main source of marine pollution. With rapid economic development in China s eastern coastal, pollutants flux into sea increase gradually. The results are that the environmental quality and seawater quality of marine have being deteriorated and pollution is serious increasingly. To meet the land demand of industrialization and urbanization, the sea reclamation has become an effective means to alleviate the contradiction between human and land in coastal area of China. This leads to large-scale reduction of coastal wetland area, and the heavy losses of ecological service value of coastal wetland. To face the environmental changes in coastal area of China and solve the contradiction among population, resources, environment, development, it is required to set up the system concept of man-land-sea relationship, so as to achieve sustainable development. The feasible measures include improving coastal management system, strengthening integrated basin management, attaching importance to construction of the coastal environment engineering, and raising the environmental monitoring and early warning level. | Yunfeng ZHANG Yingying CHEN Xiaobin HUA Shiqing YAN Lili ZOU | 2019 | Asian Agricultural Research2019，11，7： | 1 |
| 5 | Thermal stability of iridium coating prepared by MOCVD显示文摘 | Yang Wenbin Zhang Litong Hua Yunfeng | 2009 | International Journal of Refractory Metals & Hard Materials2009，27，： | 1 |
| 6 | The coexistence states of a predator-prey model with nonmonotonic functional re- sponse and diffusion 显示文摘 | Jia Yunfeng Wu Jianhua Nie Hua | 2009 | Acta Appl Math2009，108，2： | 1 |
| 7 | Concentration effects on the upconversion luminescence in Ho 3+ /Yb 3+ co-doped NaGdTiO 4 phosphor显示文摘 | Yunfeng Jiang Rensheng Shen Xiangping Li Jinsu Zhang Hua Zhong Yue Tian Jiashi Sun Lihong Cheng Haiyang Zhong Baojiu Chen | 2012 | Ceramics International2012，，6： | 1 |
| 8 | Thermal stability of iridium coating prepared by MOCVD 显示文摘 | YANG Wenbin ZHANG Litong HUA Yunfeng | 2009 | International Journal of Refractory Metals and Hard Materials2009，27，1： | 1 |
| 9 | Aligned Organization of Synapses and Mitochondria in Auditory Hair Cells显示文摘Recent studies have revealed great functional and structural heterogeneity in the ribbon-type synapses at the basolateral pole of the isopotential inner hair cell(IHC).This feature is believed to be critical for audition over a wide dynamic range,but whether the spatial gradient of ribbon morphology is fine-tuned in each IHC and how the mitochondrial network is organized to meet local energy demands of synaptic transmission remain unclear.By means of three-dimensional electron microscopy and artificial intelligence-based algorithms,we demonstrated the cell-wide structural quantification of ribbons and mitochondria in mature mid-cochlear IHCs of mice.We found that adjacent IHCs in staggered pairs differ substantially in cell body shape and ribbon morphology gradient as well as mitochondrial organization.Moreover,our analysis argues for a location-specific arrangement of correlated ribbon and mitochondrial function at the basolateral IHC pole. | Jing Liu Shengxiong Wang Yan Lu Haoyu Wang Fangfang Wang Miaoxin Qiu Qiwei Xie Hua Han Yunfeng Hua | 2022 | Neuroscience Bulletin2022，38，3： | 1 |
| 10 | MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages显示文摘Primary immune thrombocytopenia(ITP)is an autoimmune hemorrhagic disorder in which macrophages play a critical role.Mammalian sterile-20-like kinase 4(MST4),a member of the germinal-center kinase STE20 family,has been demonstrated to be a regulator of inflammation.Whether MST4 participates in the macrophage-dependent inflammation of ITP remains elusive.The expression and function of MST4 in macrophages of ITP patients and THP-1 cells,and of a macrophage-specific Mst4−/−(Mst4ΔM/ΔM)ITP mouse model were determined.Macrophage phagocytic assays,RNA sequencing(RNA-seq)analysis,immunofluorescence analysis,coimmunoprecipitation(co-IP),mass spectrometry(MS),bioinformatics analysis,and phosphoproteomics analysis were performed to reveal the underlying mechanisms.The expression levels of the MST4 gene were elevated in the expanded M1-like macrophages of ITP patients,and this elevated expression of MST4 was restored to basal levels in patients with remission after high-dose dexamethasone treatment.The expression of the MST4 gene was significantly elevated in THP-1-derived M1 macrophages.Silencing of MST4 decreased the expression of M1 macrophage markers and cytokines,and impaired phagocytosis,which could be increased by overexpression of MST4.In a passive ITP mouse model,macrophage-specific depletion of Mst4 reduced the numbers of M1 macrophages in the spleen and peritoneal lavage fluid,attenuated the expression of M1 cytokines,and promoted the predominance of FcγRIIb in splenic macrophages,which resulted in amelioration of thrombocytopenia.Downregulation of MST4 directly inhibited STAT1 phosphorylation,which is essential for M1 polarization of macrophages.Our study elucidates a critical role for MST4 kinase in the pathology of ITP and identifies MST4 kinase as a potential therapeutic target for refractory ITP. | Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
| 11 | Author Correction:MST4 kinase regulates immune thrombocytopenia by phosphorylating STAT1-mediated M1 polarization of macrophages显示文摘In this article,the details for Affiliation 1 were incorrectly given as‘Department of Hematology,Fudan University,Shanghai 200032,China’but should have been‘Department of Hematology,Zhongshan Hospital,Fudan University,Shanghai 200032,China’;the details for Affiliation 3 were incorrectly given as‘Department of Transfusion Medicine,Fudan University,Shanghai 200032,China’but should have been‘Department of Transfusion Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China’;the details for Affiliation 4 were incorrectly given as‘Department of Laboratory Medicine,Fudan University,Shanghai 200032,China’but should have been‘Department of Laboratory Medicine,Zhongshan Hospital,Fudan University,Shanghai 200032,China’.The original article has been corrected. | Jingjing Cao Lili Ji Yanxia Zhan Xia Shao Pengcheng Xu Boting Wu Pu Chen Luya Cheng Xibing Zhuang Yang Ou Fanli Hua Lihua Sun Feng Li Hao Chen Zhaocai Zhou Yunfeng Cheng | 2023 | Cellular & Molecular Immunology2023，20，12： | 0 |
| 12 | Ordered quasi-two-dimensional structure of nanoparticles in semiflexible ring polymer brushes under compression显示文摘在压缩下面的戒指聚合物刷子的一个纹理粗糙的祷告春天模型的分子的动力学模拟被介绍。灵活聚合物刷子在压缩期间总是是混乱的,而 semiflexible 聚合物刷子趋于在足够地强壮的压缩下面被订。进一步, semiflexible 聚合物刷子的聚合物单体密度在刷子表面附近很高,导致表面附近的免费精力的山峰价值。因此,当 nanoparticles 在 semiflexible 戒指聚合物刷子被压缩时,他们趋于展出在刷子表面之间的仔细包装的单个层的结构,刺不进的墙,和伪二维的订的结构接近刷子表面在强壮的压缩下面被形成。这些调查结果提供一条新途径给设计应答的应用。 | Yunfeng Hua Zhenyu Deng Yangwei Jiang Linxi Zhang | 2017 | Frontiers of physics2017，12，3： | 0 |
| 13 | A novel defined risk signature of endoplasmic reticulum stress-related genes for predicting the prognosis and immune infiltration status of ovarian cancer显示文摘Endoplasmic reticulum(ER)stress,as an emerging hallmark feature of cancer,has a considerable impact on cell proliferation,metastasis,invasion,and chemotherapy resistance.Ovarian cancer(OvCa)is one of the leading causes of cancer-related mortality across the world due to the late stage of disease at diagnosis.Studies have explored the influence of ER stress on OvCa in recent years,while the predictive role of ER stress-related genes in OvCa prognosis remains unexplored.Here,we enrolled 552 cases of ER stress-related genes involved in OvCa from The Cancer Genome Atlas(TCGA)and Gene Expression Omnibus(GEO)cohorts for the screening of prognosis-related genes.The least absolute shrinkage and selection operator(LASSO)regression was applied to establish an ER stress-related risk signature based on the TCGA cohort.A seven-gene signature revealed a favorable predictive efficacy for the TCGA,International Cancer Genome Consortium(ICGC),and another GEO cohort(P<0.001,P<0.001,and P=0.04,respectively).Moreover,functional annotation indicated that this signature was enriched in cellular response and senescence,cytokines interaction,as well as multiple immune-associated terms.The immune infiltration profiles further delineated an immunologic unresponsive status in the high-risk group.In conclusion,ER stress-related genes are vital factors predicting the prognosis of OvCa,and possess great application potential in the clinic. | Jiahang MO Shunyi RUAN Baicai YANG Yunfeng JIN Keyi LIU Xukai LUO Hua JIANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，1： | 0 |
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