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| 1 | Rhizobacterium Bacillus amyloliquefaciens Strain SQRT3-Mediated Induced Systemic Resistance Controls Bacterial Wilt of Tomato显示文摘Tomato bacterial wilt caused by Ralstonia solanacearum seriously threats tomato growth in tropical and temperate regions around the world.This study reported an antagonistic bacterial strain, Bacillus amyloliquefaciens strain SQRT3, isolated from the rhizosphere soil of tomato plants, which strongly inhibited in vitro growth of pathogenic R.solanacearum.The suppression of tomato bacterial wilt by strain SQRT3 was demonstrated under greenhouse conditions.Additionally, induced systemic resistance(ISR) in tomato as one of the potential disease suppression mechanisms was investigated in the plants inoculated with the isolated bacterial strain SQRT3.The results showed that strain SQRT3 applied with R.solanacearum by drenching significantly reduced tomato bacterial wilt by 68.1% biocontrol efficiency(BE) and suppressed the R.solanacearum populations in the rhizosphere soil compared to the control only drenched with R.solanacearum.The BE of the isolated bacterial strain SQRT3 against tomato wilt increased to 84.1%by root-dipping.Tomato plants treated with both strain SQRT3 and R.solanacearum showed increases in activities of peroxidase and polyphenol oxidase compared with other treatments.The application of strain SQRT3 reduced membrane lipid peroxidation in tomato leaves.The expressions of marker genes for jasmonic acid-and salicylic acid-dependent signaling pathways were faster and stronger in tomato plants treated with both strain SQRT3 and R.solanacearum than in plants treated with either R.solanacearum or strain SQRT3 alone.Collectively, the findings indicated that strain SQRT3 can effectively control tomato wilt. | LI Chunyu HU Weicong PAN Bin LIU Yan YUAN Saifei DING Yuanyuan LI Rong ZHENG Xinyan SHEN Biao SHEN Qirong | 2017 | Pedosphere2017，27，6： | 18 |
| 2 | In vivo self-assembled small RNAs as a new generation of RNAi therapeutics显示文摘RNAi therapy has undergone two stages of development,direct injection of synthetic siRNAs and delivery with artificial vehicles or conjugated ligands;both have not solved the problem of efficient in vivo siRNA delivery.Here,we present a proof-of-principle strategy that reprogrammes host liver with genetic circuits to direct the synthesis and self-assembly of siRNAs into secretory exosomes and facilitate the in vivo delivery of siRNAs through circulating exosomes.By combination of different genetic circuit modules,in vivo assembled siRNAs are systematically distributed to multiple tissues or targeted to specific tissues(e.g.,brain),inducing potent target gene silencing in these tissues.The therapeutic value of our strategy is demonstrated by programmed silencing of critical targets associated with various diseases,including EGFR/KRAS in lung cancer,EGFR/TNC in glioblastoma and PTP1B in obesity.Overall,our strategy represents a next generation RNAi therapeutics,which makes RNAi therapy feasible. | Zheng Fu Xiang Zhang Xinyan Zhou Uzair Ur-Rehman Mengchao Yu Hongwei Liang Hongyuan Guo Xu Guo Yan Kong Yuanyuan Su Yangyang Ye Xiuting Hu Wei Cheng Jinrong Wu Yanbo Wang Yayun Gu Sheng-feng Lu Dianqing Wu Ke Zen Jing Li Chao Yan Chen-Yu Zhang Xi Chen | 2021 | Cell Research2021，31，6： | 10 |
| 3 | PREDICTION OF FATIGUE LIVES OF RC BEAMS STRENGTHENED WITH CFL UNDER RANDOM LOADING显示文摘与纤维加强的结构在随机下面把压成薄片装载的增强的水泥(RC ) 的疲劳生活上的调查为修理或加强桥和交通的安全是重要的。在这份报纸,二个方法为在基于剩余生活和一个剩余力量模型的随机的装载下面预言与碳纤维加强的结构把压成薄片的 RC (CFL ) 的疲劳生活被开发。为了讨论模型,的效率,与 CFL 加强的 12 根 RC 横梁在由 MTS810 严峻的系统的随机的装载下面被测试。预言的剩余力量近似同意测试结果。 | Rongwei Lin Peiyan Huang Chen Zhao Xinyan Guo Xiaohong Zheng | 2008 | Acta Mechanica Solida Sinica2008，21，4： | 4 |
| 4 | Effects of biochar amendment on soil quality, crop yield and greenhouse gas emission in a Chinese rice paddy: A field study of 2 consecutive rice growing cycles显示文摘 | Afeng Zhang Rongjun Bian Genxing Pan Liqiang Cui Qaiser Hussain Lianqing Li Jinwei Zheng Jufeng Zheng Xuhui Zhang Xiaojun Han Xinyan Yu | 2011 | Field Crops Research2011，，： | 4 |
| 5 | Boosting the kinetics of PF_(6)^(-) into graphitic layers for the optimal cathode of dual-ion batteries:The rehearsal of pre-intercalating Li^(+)显示文摘Large anions exhibit slow diffusion kinetics in graphite cathode of dual-ion batteries(DIBs);particularly at high current density,it suffers severely from the largely-reduced interlayer utilization of graphite cathode,which as a bottleneck limits the fast charge application of DIBs.To maximize interlayer utilization and achieve faster anion diffusion kinetics,a fast and uncrowded anion transport channel must be established.Herein,Li^(+)was pre-intercalated into the graphite paper(GP)cathode to increase the interlayer spacing,and then hosted for the PF_(6)^(-)anion storage.Combined with theoretical calculation,it shows that the local interlayer spacing enlargement and the residual Li^(+)reduce the anion intercalation energy and diffusion barrier,leading to better rate stability.The obtained GP with Li^(+)pre-intercalation(GP-Li)electrode exhibits a discharge capacity of 23.1 m Ah g^(-1) at a high current of 1300 m A g^(-1).This work provides a facile method to efficiently improve the interlayer utilization of graphite cathode at large currents. | He Yang Tingting Qin Xinyan Zhou Yu Feng Zizhun Wang Xin Ge Nailin Yue Dabing Li Wei Zhang Weitao Zheng | 2022 | Journal of Energy Chemistry2022，31，8： | 2 |
| 6 | Effects of amendment of biochar-manure compost in conjunction with pyroligneous solution on soil quality and wheat yield of a salt-stressed cropland from Central China Great Plain显示文摘 | Muhammad Siddique Lashari Yuming Liu Lianqing Li Weinan Pan Jiaying Fu Genxing Pan Jufeng Zheng Jinwei Zheng Xuhui Zhang Xinyan Yu | 2012 | Field Crops Research2012，，： | 1 |
| 7 | Biochar soil amendment increased bacterial but decreased fungal gene abundance with shifts in community structure in a slightly acid rice paddy from Southwest China显示文摘 | Junhui Chen Xiaoyu Liu Jinwei Zheng Bin Zhang Haifei Lu Zhongzhi Chi Genxing Pan Lianqing Li Jufeng Zheng Xuhui Zhang Jiafang Wang Xinyan Yu | 2013 | Applied Soil Ecology2013，，： | 1 |
| 8 | Holocene loess and its deposition dynamics in the upper reaches of the Huaihe River显示文摘灰尘来源和搬运系统是在 loess-palaeosol 累积的进程的二个不可缺少的方面。黄土高原的灰尘主要来自西北的内陆 gobi 和沙漠,这被证明了,由东亚季风系统和 westerlies 搬运了。然而,几乎关于灰尘来源和 Huaihe 河的上面的活动范围的免职动力学没有小研究。在现在的学习,我们在 Huaihe 河的上面的活动范围与高分辨率调查了并且收集 YPC 节。按年代先后的框架被标明日期的光学地刺激的光(OSL ) 重建并且与出版黄土时间系列相关。由磁性的危险性( MS )和在 YPC 侧面, XJN 侧面(西方的黄土高原)和 JYC 侧面(南部的黄土高原)之中的黄土土壤侧面的谷物尺寸( GS )的比较,我们发现在 Huaihe 河和黄土高原的上面的活动范围之间的类似的气候变化和 pedogenic 过程,两个都在最后期间经历了干燥的极端和最弱的成土作用冰川,列在后面由一过渡事件从寒冷干燥对温暖潮湿的 mid-Holocene 和增加上次冰川但是在 Huaihe 河的上面的活动范围的黄土土壤侧面序列的 MS 是比在黄土高原的那些低得多的,并且 GS 是比在黄土高原的那些粗糙得多的。为这三侧面的 GS 的比较表明有不同灰尘来源,它属于不同风神的搬运系统。在 Huaihe 河的上面的活动范围的黄土是吹的风近的来源的免职,当更粗糙的灰尘主要来自松开的冲积存款时冲积并且黄河的 proluvial 扇子。Huaihe 河里的灰尘的让步并且带的动力学是东北风在冬季占优势半年。 | HE Zhong HUANG Chunchang ZHENG Hongbo ZHOU Jie PANG Jiangli LI Xinyan WANG Lijun | 2011 | Journal of Geographical Sciences2011，21，3： | 1 |
| 9 | Licochalcone A inhibiting proliferation of bladder cancer T24 cells by inducing reactive oxygen species production显示文摘 | Feng Liu Ali Goodarzi Haifeng Wang Joanna Stasiak Jianbo Sun Yu Zhou Jiangtao Jiang Xuan Yuan Hong Zhao Xinyan Yan Xiling Sun Qiusheng Zheng | 2014 | Bio-Medical Materials and Engineering2014，，1： | 1 |
| 10 | Flexural Performance of Reinforced Concrete Beams Strengthened with Carbon Fiber-Reinforced Polymer(CFRP)under Hygrothermal Environment Considering the Influence of CFRP-Concrete Interface显示文摘As an important component,the bond behavior of carbon fiber-reinforced polymer(CFRP)-concrete interface for a reinforced concrete(RC)beam is very significant.In this study,a theoretical model was established to analyze the flexural behavior of CFRP-strengthened RC beams,and the CFRP-concrete interfacial bond-slip relationship under hygrothermal environment was unified into one model.Two failure criteria corresponding to two types of failure modes,i.e.,concrete crushing and intermediate crack(IC)-induced debonding,were developed.Through the theoretical model,the flexural behavior of deflection,interfacial shear stress distribution and ultimate load of a CFRP-strengthened RC beam under hygrothermal environment were obtained and predicted.Moreover,the theoretical model was verified by test results.The results showed that the hygrothermal environment had a significant impact on the CFRP-concrete interface behavior.Compared with the control beam without hygrothermal environment pretreatment,the deflection and ultimate load of the strengthened RC beam decreased by 51.9%and 20%,respectively. | Xinyan Guo Peiyan Huang Yilin Wang Shenyunhao Shu Xiaohong Zheng | 2021 | Acta Mechanica Solida Sinica2021，34，3： | 1 |
| 11 | Iron(Fe,Ni,Co)-based transition metal compounds for lithium-sulfur batteries:Mechanism,progress and prospects显示文摘Lithium-sulfur batteries(LSBs)have a high theoretical capacity,which is considered as one of the most promising high-energy-density secondary batteries due to the double electrons reaction of sulfur.However,the shuttle effects of lithium polysulfides(Li PSs)and sluggish redox kinetics lead to their materials capacity loss and cycle stability deterioration,which restrains LSBs commercialization.Metallic compounds as additions can improve the electrochemical performance of the Li-S system,through the trap of Li PSs and accelerate the conversion of the soluble Li PSs.Among of them,the iron group elements(Fe,Ni,Co)-based compounds are the promising materials for the LSBs,due to their unique outer electronic structure and its tunable properties,low cost,abundant in the earth,environmental benignity,controllable and scalable prepared,and so on.In this review,we have made a summary for iron-based compounds to capture Li PSs according to lithium bond,sulfur bond and magnetic force.The type of iron-based compound including oxides,sulfides,nitrides,phosphides,carbides,and so on,and we have investigated the electrocatalytic mechanism of these materials.Besides,some improvement strategies are proposed,such as the engineering of the special micro/nanostructure,defect concentrations,band structures,and heterostructures.We hope to shed an in-depth light on the rationally design and fabrication of robust,commercial and stable materials for high-performance LSBs. | Junhao Li Zhangshi Xiong Yujie Wu Hao Li Xinyan Liu Hongjie Peng Yuying Zheng Qiang Zhang Quanbing Liu | 2022 | Journal of Energy Chemistry2022，31，10： | 0 |
| 12 | Introduction of N,N’-disulfonylhydrazines as new sulfonylating reagents for highly efficient synthesis of(E)-β-iodovinyl arenesulfones under mild conditions显示文摘N,N’-Disulfonylhydrazines have been proven to be the most reactive precursors of the sulfonyl radicals among all types of sulfonyl substituted hydrazines as early as half a century ago.However,the sulfonyl radicals generated from these compounds have not been used in organic synthesis except the simple selfdimerization synthesis of disulfones controlled by the'solvent-cage-effects'.In this article,N,N’-disulfonylhydrazines were introduced as new sulfonylating reagents and their combinations with NIS were disclosed as new iodosulfonylating reagents of allcynes.Finally,a highly efficient method for the synthesis of(E)-β-iodovinyl arenesulfones was developed by mixing an alkyne,a N,N’-disulfonylhydrazine and NIS in aqueous THF at room temperature for 5 min. | Dongping Luo Lin Min Weiping Zheng Lidong Shan Xinyan Wang Yuefei Hu | 2020 | Chinese Chemical Letters2020，31，7： | 0 |
| 13 | Individually-atomic governing d-π*orbital interactions via Cupromoted optimization of Fe-d band centers for high-efficiency zinc-air battery显示文摘It is challenging for precise governing of electronic configuration of the individually-atomic catalysts toward optimal electrocatalysis,as d-band configuration of a metal center determines the adsorption behavior of reactive species to the center in oxygen reduction reaction(ORR).The addition of Cu atom modifies the d-band center position of Fe central atom,thus strengthening the d-π*orbital interactions.Herein,FeCu-NC catalyst in the nitrogen-doped carbon(NC)support containing individual dual-metal CuN4/FeN4 sites was prepared by the surface confinement strategy of zeolitic imidazolate framework(ZIF),treated as a model catalyst.Experimentally and theoretically co-verified dual-metal CuN4/FeN4 sites highly dispersed in the NC support,enable transferring more electrons from FeN4 sites to*OH intermediates,thereby accelerating the desorption process of*OH species.Superior to those commercial Pt/C,Our FeCu-NC catalyst exhibited extraordinary ORR activity(with a E1/2 as high as 0.87 V)and cycling stability in 0.1 M KOH electrolyte,and thereof demonstrated excellent discharge performance in zinc-air batteries.Our construction of dual-atom catalysts(DACs)provides a strategy for atom-by-atom designing high-efficiency catalysts via orbital regulation. | Xinyan Zhou Kexin Song Yu Feng Chao Jiang Zhongjun Chen Zizhun Wang Nailin Yue Xin Ge Wei Zhang Weitao Zheng | 2023 | Nano Research2023，16，4： | 0 |
| 14 | Therapeutic application of chick early amniotic fluid: effective rescue of acute myocardial ischemic injury by intravenous administration显示文摘Myocardial regeneration has been considered a promising option for the treatment of adult myocardial injuries.Previously,a chick early amniotic fluid(ceAF)preparation was shown to contain growth-related factors that pro-moted embryonic growth and cellular proliferation,though the nature of the components within ceAF were not fully defined.Here we tested whether this ceAF preparation is similarly effective in the promotion of myocardial regen-eration,which could provide an alternative therapeutic for intervening myocardial injury.In this study,a myocardial ischemic injury model was established in adult mice and pigs by multiple research entities,and we were able to show that ceAF can efficiently rescue damaged cardiac tissues and markedly improve cardiac function in both experimental models through intravenous administration.ceAF administration increased cell proliferation and improved angio-genesis,likely via down-regulation of Hippo-YAP signaling.Our data suggest that ceAF administration can effectively rescue ischemic heart injury,providing the key functional information for the further development of ceAF for use in attenuating myocardial injury. | Baiping Cui Yufan Zheng Xiang Gao Lihong Zhang Borui Li Jia Chen Xinyan Zhou Mengyuan Cai Wenrui Sun Yuting Zhang Keejong Chang Jiayi Xu Fuyin Zhu Yan Luo Tao Sun Jin Qian Ning Sun | 2022 | Cell Regeneration2022，11，1： | 0 |
| 15 | Toxic effects of long-term dual or single exposure to oxytetracycline and arsenic on Xenopus tropicalis living in duck wastewater显示文摘Direct discharge of aquaculture wastewater may have toxic effects,due to the presence of heavy metals,antibiotics,and even resistant pathogens,but little attention has been given.Here,tanks simulating a wild ecosystem were built to study the effects of long-term exposure to duckwastewater containing oxytetracycline(OTC)and/or arsenic(As)on the growth,physiological function,and gut microbiota evolution of Xenopus tropicalis.The results showed that duck wastewater had no apparent impact on X.tropicalis,but the impact increased significantly(P<0.05)with exposure to OTC and/or As,especially the impact on body weight and growth rate.Biochemical indicators revealed varying degrees of oxidative stress damage,hepatotoxicity(inflammation,necrosis,and sinusoids),and collagen fibrosis of X.tropicalis in all treated groups after 72 days of exposure,which indirectly inhibited X.tropicalis growth.Moreover,16S rDNA amplicon sequencing results showed that the gut microbiota structure and metabolic function were perturbed after chronic exposure,which might be the leading cause of growth inhibition.Interestingly,the abundance of intestinal resistance genes(RGs)increased with exposure time owing to the combined direct and indirect effects of stress factors in duck wastewater.Moreover,once the RGs were expressed,the resistance persisted for at least 24 days,especially that conferred by tetA.These results provide evidence of the toxic effects of DW containing OTC(0.1–4.0 mg/L)and/or As(0.3–3.5μg/L)on amphibians and indicate that it is vital to limit the usage of heavy metals and antibiotics on farms to control the biotoxicity of wastewater. | Jianbin Zhao Xinyan Li Yanbin Xu Yuxin Li Li Zheng Tiangang Luan | 2023 | Journal of Environmental Sciences2023，，5： | 0 |
| 16 | Pd@Ir-LOD multienzyme utilizing endogenous lactate consumption cooperates with photothermal for tumor therapy显示文摘Lactic acid(LA)plays a major role in the occurrence,development,and spread of cancer.Enlightened by its high accumulation in tumor site,a novel lactate oxidase(LOD)conjugated two-dimensional Pd@Ir nanoplatform(Pd@Ir-LOD,PIL)was fabricated to combine cascade reaction with photothermal for tumor therapy.In detail,the overexpressed LA in tumor microenvironment(TME)was a key factor to activate the PIL-based cascade reaction:(1)Plenty of H_(2)O_(2)could be generated from LA by the catalysis of LOD with O_(2);(2)potent·OH was produced from H_(2)O_(2)due to the peroxidase(POD)-like activity of PIL;(3)meantime,PIL’s catalase(CAT)-like activity could decompose part H_(2)O_(2)into O_(2)to achieve the purpose of LA cyclic oxidization.Moreover,the reduced glutathione(GSH)scavenging capability of PIL might protect the produced reactive oxygen species(ROS)from being cleared to further improve the cascade therapeutic effect.More importantly,PIL had excellent photothermal conversion efficiency(37.35%)and manifested a surprising temperature rising effect in tumor.Taken together,the decreasing LA concentration,accumulation of high-toxic ROS,the depletion of GSH together with the higher intra-tumoral temperature potently enhanced in vivo antitumor therapy.Therefore,a promising therapeutic tactic based on PIL integrating endogenous LA consumption,chemodynamic therapy(CDT),and photothermal therapy(PTT)has been put forward. | Zichen Ye Yun Li Jingchao Li Xinyan Hu Jinyang Zheng Gongxin Zhang Sijin Xiang Tianbao Zhu Zhide Guo Xiaolan Chen | 2024 | Nano Research2024，17，1： | 0 |
| 17 | Research on LLR Soil Cleaning and Decontamination Technology显示文摘The research on decontamination technology of radioactive contaminated soil began in the 1980s.It mainly draws on the experience of soil treatment technology for dealing with heavy metal ion pollution.In the decontamination technology research and development of radioactive contaminated soil,soil cleaning is considered to be the most engineering application,due to the low cost of soil cleaning treatment,simple process,wide applicability and mature technology,which can obtain a large degree of volume reduction and better decontamination efficiency.In this study,the radionuclides in the very low-level soil of CIAE were removed by cleaning reagents,and then the leaching solution was regenerated by chemical flocculation and then recycled,which finally enabled the contaminated soil to meet the requirements of clearance. | ZHENG Zuoxi ZHANG Yi ZHU Xinyan | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
| 18 | Efficient ORR catalysts for zinc-air battery: Biomass-derived ultra-stable Co nanoparticles wrapped with graphitic layers via optimizing electron transfer显示文摘The poor stability of non-noble metal catalysts in oxygen reduction reaction(ORR) is a main bottleneck that limits their big-scale application in metal-air batteries. Herein, we construct a chainmail catalyst(Co-NC-AD) with outstanding stability, via the competitive complexation and post absorption strategy,consisting of highly graphitic layers wrapped uniform-size Co nanoparticles(Co-NPs). Experiments combined with density functional theory(DFT) calculations jointly confirmed that the electron transfer occurred from the inner Co-NPs to the external graphitic layers. It facilitated the adsorption process of oxygen molecules and the hybridization of the O-2 p and C-1 p orbitals, which accelerated the ORR reaction kinetics. Consequently, our prepared Co-NC-AD shows excellent ORR activity, offered with a more positive initial potential(E_(onset)= 0.95 V) and half-wave potential(E_(1/2)= 0.86 V). The remarkable stability and resistance of methanol poisoning are merited from the protection effect of stable graphitic layers. In addition, the high electrochemical performance of Co-NC-AD-based zinc-air battery demonstrates their potential for practical applications. Therefore, our work provides new ideas for the design of nanoconfined catalysts with high stability and activity. | Yu Feng Kexin Song Wei Zhang Xinyan Zhou Seung Jo Yoo Jin-Gyu Kim Sifan Qiao Yugang Qi Xu Zou Zhongjun Chen Tingting Qin Nailin Yue Zizhun Wang Dabing Li Weitao Zheng | 2022 | Journal of Energy Chemistry2022，31，7： | 0 |
| 19 | Isogenic human pluripotent stem cell disease models reveal ABRA deficiency underlies cTnT mutation-induced familial dilated cardiomyopathy显示文摘Dear Editor,Dilated cardiomyopathy(DCM)is a common form of inherited cardiomyopathy.In the past decades,single mutations in various genes encoding sarcomeric,cytoskeletal,and channel proteins etc.have been found to be associated with DCM(Hershberger et al.,2013;McNally and Mestroni,2017).However,the mechanisms how single mutations in sarcomeric or structural genes lead to the disease remain elusive.An interesting phenomenon often seen in familial cardiomyopathy is that different single mutations on the same gene can cause either DCM or hypertrophic cardiomyopathy(HCM)(Kathiresan and Srivastava,2012),which exhibit almost opposite disease phenotypes.DCM is characterized by thinned myocardium and septum,ventricular chamber dilation,and systolic dysfunction(Jefferies and Towbin,2010;McNally and Mestroni,2017),while HCM exhibits thickened myocardium and septum,reduced ventricular chamber,and diastolic dysfunction(Richard et al.,2003).At the cellular level,HCM cardiomyocytes exhibit concentric hypertrophy characterized by assembly of myofilaments in parallel and widening of the myocytes.In contrast,DCM cardiomyocytes show eccentric hypertrophy,with assembly of the myofilaments in series and myocyte elongation(Kehat and Molkentin,2010). | Bin Li Yongkun Zhan Qianqian Liang Chen Xu Xinyan Zhou Huanhuan Cai Yufan Zheng Yifan Guo Lei Wang Wenqing Qiu Baiping Cui Chao Lu Ruizhe Qian Ping Zhou Haiyan Chen Yun Liu Sifeng Chen Xiaobo Li Ning Sun | 2022 | Protein & Cell2022，13，1： | 0 |
| 20 | The choice of a neoadjuvant chemotherapy cycle for breast cancer has significance in clinical practice: results from a population-based, real world study显示文摘Objective:Neoadjuvant chemotherapy(NAC)is currently used in both early stage and locally advanced breast cancers.The survival benefits of standard vs.non-standard NAC cycles are still unclear.This study aimed to investigate the relationship between NAC cycles and survival based on real world data.Methods:We identified patients diagnosed with invasive primary breast cancers who underwent NAC followed by surgery.Patients who received at least 4 NAC cycles were defined as having received standard cycles,while patients who received less than 4 NAC cycles were defined as having received non-standard cycles.Kaplan-Meier curves and Cox proportional hazard models were used to estimate the disease-free survival(DFS)and overall survival(OS).Results:Of the 1,024 included patients,700 patients received standard NAC cycles and 324 patients received non-standard NAC cycles.The DFS estimates were 87.1%and 81.0%(P=0.007)and the OS estimates were 90.0%and 82.6%(P=0.001)in the standard and non-standard groups,respectively.Using multivariate analyses,patients treated with standard NAC cycles showed significant survival benefits in both DFS[hazard ratio(HR):0.62,95%confidence interval(CI):0.44–0.88]and OS(HR:0.54,95%CI:0.37–0.79).Using stratified analyses,standard NAC cycles were associated with improved DFS(HR:0.59,95%CI:0.36–0.96)and OS(HR:0.49,95%CI:0.28–0.86)in the HER2 positive group.Similar DFS(HR:0.50,95%CI:0.25–0.98)and OS(HR:0.45,95%CI:0.22–0.91)benefits were shown for the triple negative group.Conclusions:Standard NAC cycles were associated with a significant survival benefit,especially in patients with HER2 positive or triple negative breast cancer. | Litong Yao Zhiyuan Pang Mozhi Wang Mengshen Wang Xiangyu Sun Mingke Cui Yanfu Zheng Xinyan Li Haoran Dong Qiang Zhang Yingying Xu | 2022 | Cancer Biology & Medicine2022，19，5： | 0 |
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