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1Terrestrial carbon sinks in China and around the world and their contribution to carbon neutrality显示文摘Enhancing the terrestrial ecosystem carbon sink(referred to as terrestrial C sink) is an important way to slow down the continuous increase in atmospheric carbon dioxide(CO_(2)) concentration and to achieve carbon neutrality target.To better understand the characteristics of terrestrial C sinks and their contribution to carbon neutrality,this review summarizes major progress in terrestrial C budget researches during the past decades,clarifies spatial patterns and drivers of terrestrial C sources and sinks in China and around the world,and examines the role of terrestrial C sinks in achieving carbon neutrality target.According to recent studies,the global terrestrial C sink has been increasing from a source of (-0.2±0.9) Pg C yr^(-1)(1 Pg=1015g)in the 1960s to a sink of (1.9±1.1) Pg C yr^(-1) in the 2010s.By synthesizing the published data,we estimate terrestrial C sink of 0.20–0.25 Pg C yr^(-1) in China during the past decades,and predict it to be 0.15–0.52 Pg C yr^(-1) by 2060.The terrestrial C sinks are mainly located in the mid-and high latitudes of the Northern Hemisphere,while tropical regions act as a weak C sink or source.The C balance differs much among ecosystem types:forest is the major C sink;shrubland,wetland and farmland soil act as C sinks;and whether the grassland functions as C sink or source remains unclear.Desert might be a C sink,but the magnitude and the associated mechanisms are still controversial.Elevated atmospheric CO_(2) concentration,nitrogen deposition,climate change,and land cover change are the main drivers of terrestrial C sinks,while other factors such as fires and aerosols would also affect ecosystem C balance.The driving factors of terrestrial C sink differ among regions.Elevated CO_(2) concentration and climate change are major drivers of the C sinks in North America and Europe,while afforestation and ecological restoration are additionally important forcing factors of terrestrial C sinks in China.For future studies,we recommend the necessity for intensive and long-term ecosystem C monitoring over broad geographic scale to improve terrestrial biosphere models for accurately evaluating terrestrial C budget and its dynamics under various climate change and policy scenarios.Yuanhe Yang Yue Shi Wenjuan Sun Jinfeng Chang Jianxiao Zhu Leiyi Chen Xin Wang Yanpei Guo Hongtu Zhang Lingfei Yu Shuqing Zhao Kang Xu Jiangling Zhu Haihua Shen Yuanyuan Wang Yunfeng Peng Xia Zhao Xiangping Wang Huifeng Hu Shiping Chen Mei Huang Xuefa Wen Shaopeng Wang Biao Zhu Shuli Niu Zhiyao Tang Lingli Liu Jingyun Fang 2022Science China(Life Sciences)2022,65,5:32
2Rhizobacterium Bacillus amyloliquefaciens Strain SQRT3-Mediated Induced Systemic Resistance Controls Bacterial Wilt of Tomato显示文摘Tomato bacterial wilt caused by Ralstonia solanacearum seriously threats tomato growth in tropical and temperate regions around the world.This study reported an antagonistic bacterial strain, Bacillus amyloliquefaciens strain SQRT3, isolated from the rhizosphere soil of tomato plants, which strongly inhibited in vitro growth of pathogenic R.solanacearum.The suppression of tomato bacterial wilt by strain SQRT3 was demonstrated under greenhouse conditions.Additionally, induced systemic resistance(ISR) in tomato as one of the potential disease suppression mechanisms was investigated in the plants inoculated with the isolated bacterial strain SQRT3.The results showed that strain SQRT3 applied with R.solanacearum by drenching significantly reduced tomato bacterial wilt by 68.1% biocontrol efficiency(BE) and suppressed the R.solanacearum populations in the rhizosphere soil compared to the control only drenched with R.solanacearum.The BE of the isolated bacterial strain SQRT3 against tomato wilt increased to 84.1%by root-dipping.Tomato plants treated with both strain SQRT3 and R.solanacearum showed increases in activities of peroxidase and polyphenol oxidase compared with other treatments.The application of strain SQRT3 reduced membrane lipid peroxidation in tomato leaves.The expressions of marker genes for jasmonic acid-and salicylic acid-dependent signaling pathways were faster and stronger in tomato plants treated with both strain SQRT3 and R.solanacearum than in plants treated with either R.solanacearum or strain SQRT3 alone.Collectively, the findings indicated that strain SQRT3 can effectively control tomato wilt.LI Chunyu HU Weicong PAN Bin LIU Yan YUAN Saifei DING Yuanyuan LI Rong ZHENG Xinyan SHEN Biao SHEN Qirong 2017Pedosphere2017,27,6:18
3Monodisperse core-shell structured magnetic mesoporous aluminosilicate nanospheres with large dendritic mesochannels显示文摘合理设计和有一个定制的活跃核心和大、树枝状的、修改 mesoporous 的多功能的混合 nanostructures 的精确合成组织了壳能支持催化作用,精力存储,和生物应用。这里,油水双相层化涂层策略被开发了准备 monodisperse 磁性的树枝状的 mesoporous 硅石核心壳结构化的 nanospheres。这些复杂 Fe 3 O 4@SiO2@dendritic-mSiO2 nanospheres 特征大树枝状的开的毛孔(2.7 和 10.3 nm ) 。显著地,硅石壳能与未改变的孔, 14 的 Si/Al 臼齿的比率,和显著地强壮的酸的地点被变换成树枝状的 mesoporous 铝矽酸盐框架,通过一条合成以后的途径。另外,结果的磁性的树枝状的 mesoporous 铝矽酸盐 nanospheres 展览在从废水的磷酸盐移动的突出的性质和有希望的申请。Jianping Yang Dengke Shen Yong Wei Wei Li Fan Zhang Biao Kong Shaohua Zhang Wei Teng Jianwei Fan Weixian Zhang Shixue Dou Dongyuan Zhao 2015Nano Research2015,8,8:11
4Salivary mycobiome dysbiosis and its potential impact on bacteriome shifts and host immunity in oral lichen planus显示文摘The biodiversity of the mycobiome,an important component of the oral microbial community,and the roles of fungal–bacterial and fungal–immune system interactions in the pathogenesis of oral lichen planus (OLP) remain largely uncharacterized.In this study,we sequenced the salivary mycobiome and bacteriome associated with OLP.First,we described the dysbiosis of the microbiome in OLP patients,which exhibits lower levels of fungi and higher levels of bacteria.Significantly higher abundances of the fungi Candida and Aspergillus in patients with reticular OLP and of Alternaria and Sclerotiniaceae_unidentified in patients with erosive OLP were observed compared to the healthy controls.Aspergillus was identified as an “OLP-associated” fungus because of its detection at a higher frequency than in the healthy controls.Second,the co-occurrence patterns of the salivary mycobiome–bacteriome demonstrated negative associations between specific fungal and bacterial taxa identified in the healthy controls,which diminished in the reticular OLP group and even became positive in the erosive OLP group.Moreover,the oral cavities of OLP patients were colonized by dysbiotic oral flora with lower ecological network complexity and decreased fungal–Firmicutes and increased fungal–Bacteroidetes sub-networks.Third,several keystone fungal genera (Bovista,Erysiphe,Psathyrella,etc.) demonstrated significant correlations with clinical scores and IL-17 levels.Thus,we established that fungal dysbiosis is associated with the aggravation of OLP.Fungal dysbiosis could alter the salivary bacteriome or may reflect a direct effect of host immunity,which participates in OLP pathogenesis.Yan Li Kun Wang Bo Zhang Qichao Tu Yufei Yao Bomiao Cui Biao Ren Jinzhi He Xin Shen Joy D.Van Nostrand Jizhong Zhou Wenyuan Shi Liying Xiao Changqing Lu Xuedong Zhou 2019International Journal of Oral Science2019,11,3:8
5Genistein protects hippocampal neurons against injury by regulating calcium/calmodulin dependent protein kinase Ⅳ protein levels in Alzheimer's disease model rats显示文摘Genistein has a neuroprotective effect in Alzheimer's disease, but its mechanism of action needs further clarification. Accumulating evidence suggests that excessive phosphorylation of tau protein causes production of neurofibrillary tangles, which is one of the main pathological characteristics of Alzheimer's disease, and tau protein can be phosphorylated by calcium/calmodulin dependent protein kinase IV(CAMK4). After 7 days of pre-administration of genistein(90 mg/kg), an Alzheimer's disease rat model was established using an intraperitoneal injection of D-galactose combined with an intracerebral injection of amyloid-β peptide(25–35). The rat was then continuously administered genistein(90 mg/kg) for 42 days. The Morris water maze test, western blotting and hematoxylin-eosin staining results showed that genistein significantly decreased the escape latency and increased the number of times crossing the platform, reduced p-tau, CALM, CAMKK1 and p-CAMK4 protein levels in the hippocampus, and alleviated hippocampal neuron damage. These findings indicate that genistein may play a neuroprotective role in Alzheimer's disease through regulating CAMK4 to modulate tau hyperphosphorylation.Shu Ye Ting-ting Wang Biao Cai Yan Wang Jing Li Ji-xian Zhan Guo-ming Shen 2017Neural Regeneration Research2017,12,9:7
6Predictors of post coronary artery bypass grafting atrial fibrillation显示文摘Objective: To investigate the incidence and relative risk factors of post coronary artery bypass grafting(post-CABG) atrial fibrillation(AF). Methods: 312 patients with CABG were reviewed and divided into an AF group and a non-AF group. Statistical analysis was used to compare the data between the two groups and screen for risk factors of post-CABG AF. Results: 103/312 (33.01%) patients developed post-CABG AF. Univariate analysis showed that patients in AF group compared with those in non-AF group were more likely to have advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm), a history of AF, prolonged p-wave duration (≥120 ms) and increased number of grafts (≥3). Multivariate logistic regression analysis showed that advanced age (≥70 years), early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement (≥40 mm) and a history of AF were highly related to post-CABG AF. Conclusion: The incidence of AF in patients following CABG was 33.01% in this study. Advanced age, early postoperative withdrawal of β-blockers, hypertension, left atrial enlargement and a history of AF were independent risk factors of post-CABG AF.Tongtong Shen Qijun Shan Biao Yuan Bing Yang Chun Chen Dongjie Xu Minglong Chen Jiangang Zou Kejiang Cao 2007Journal of Nanjing Medical University2007,21,3:5
7Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016.Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji 2017Chinese Journal of Cancer Research2017,29,2:5
8Clinical significance of germline copy number variation in susceptibility of human diseases显示文摘Germline copy number variation(CNV) is considered to be an important form of human genetic polymorphisms. Previous studies have identified amounts of CNVs in human genome by advanced technologies, such as comparative genomic hybridization, single nucleotide genotyping, and high-throughput sequencing. CNV is speculated to be derived from multiple mechanisms, such as nonallelic homologous recombination(NAHR) and nonhomologous end-joining(NHEJ). CNVs cover a much larger genome scale than single nucleotide polymorphisms(SNPs), and may alter gene expression levels by means of gene dosage, gene fusion, gene disruption, and long-range regulation effects, thus affecting individual phenotypes and playing crucial roles in human pathogenesis. The number of studies linking CNVs with common complex diseases has increased dramatically in recent years. Here, we provide a comprehensive review of the current understanding of germline CNVs, and summarize the association of germline CNVs with the susceptibility to a wide variety of human diseases that were identified in recent years. We also propose potential issues that should be addressed in future studies.Liwen Hu Xinyue Yao Hairong Huang Zhong Guo Xi Cheng Yang Xu Yi Shen Biao Xu Demin Li 2018Journal of Genetics and Genomics2018,45,1:4
9ST-Segment Elevation Myocardial Infarction Patients Complicated by Out-of-Hospital Cardiac Arrest May Not Benefit from Emergency Percutaneous Intervention显示文摘Kun Wang Yu Shen Pei-Wen Li Rong Go Jing-Mei Zhang Lian Wang Jian Bai Biao Xu 2018Chinese Medical Journal2018,,6:3
10Cholera Caused by a New Clone of Serogroup O1 Vibrio cholerae-Beijing Municipality,China,June 2021显示文摘Several lineages have been identified in the population of serogroup O1 Vibrio cholerae(V.cholerae)(1-3).The strains,which were responsible for the ongoing seventh cholera pandemic,were in Lineage 2.Nearly all the V.cholerae strains in this lineage carried genes coding cholera toxin(ctxAB)(1-2).Lineage 3b consists of strains isolated from different continents and the vast majority of strains in this lineage lack the ctxAB genes.Hanqiu Yan Bo Pang Xin Lu Zhiyong Gao Pan Lu Xin Zhang Mengyu Wang Lingyu Shen Wenxuan Zhao Jianhong Zhao Weili Liang Lei Jia Haijian Zhou Zhigang Cui Xiaoli Du Biao Kan Quanyi Wang 2022China CDC weekly2022,4,2:3
11Synthesis of Spirostanol Saponins via Gold(Ⅰ)-Catalyzed Glycosylation in the Presence of Ga(Otf)3, In(Otf)3, or HOTf显示文摘Summary of main observation and conclusion An effective approach relying on a Lewis acid-or Brφnsted acid-assisted gold(Ⅰ)-catalyzed glycosylation has been reported in the synthesis of a panel of the representative natural spirostanol saponins,namely polyphyllin D (1),polyphyllin V (2),dioscin (3),formosanin C (4),and a derivative of polyphyllin D bearing a terminal azide group (5).This approach highlights the engagement of low Ioadings of Ph3AuPOTf (≤ 0.5mol%) in the presence of Ga(OTf)3,In(OTf)3,or HOTf (~10 mol%) as a co-catalyst,at practical reaction rates as an alternative to the conventional ~10 mol%Ioadings of the gold(Ⅰ) catalyst in the glycosylation.Polyphyllin D (1) was obtained in 41% overall yield over six steps compared to the maximum 30% yield in previous syntheses,where conventional donors and promoters were used.By exploiting a regioselective rhamnosylation,a 'one-pot' approach was adopted to assemble 1 and 5,thus further strengthening the efficiency of the gold(Ⅰ)-catalyzed glycosylation.Teddy Stephen Ehianeta Dacheng Shen Peng Xu Biao Yu 2019Chinese Journal of Chemistry2019,37,8:2
12Risk factors associated with hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation显示文摘Hemorrhagic cystitis(HC)is a common complication of allogeneic hematopoietic stem cell transplantation(HSCT).The incidence is about 7%to 68%,and some patients have to suffer a long period of frequent,urgent,and painful urination,which brings great pain.This study aimed to analyze risk factors of HC and its effect on patient survival.We collected the medical records of 859 patients who underwent HSCT at our hospital between August 2016 and August 2020.Patients with and without HC were matched using propensity score matching at a 1:1 ratio based on sex,age,and diagnosis,and logistic regression analyses were used to identify factors associated with HC.We used Kaplan–Meier curves to analyze the survival rates of patients in the HC and non-HC groups.We also analyzed the relationship between BK viral load and the occurrence of HC using receiver operating characteristic curve(ROC)analysis.After propensity score matching,there were 131 patients each in the HC and non-HC groups.In the HC group,89 patients(67.9%)had mild HC(stage II°)and 43(32.1%)had severe HC(stage III–IV).The median interval between stem cell transplantation and HC development was 31(3–244)days.Univariate analysis indicated that donor age,hematopoietic stem cell source,HLA,acute graft-versus-host disease,busulfan,anti-thymocyte globulin(ATG),total body irradiation,cytomegalovirus(CMV)(urine),and BK polyomavirus(BKV)(urine)were significantly associated with HC.ATG,CMV(urine),and BKV(urine)were independent risk factors for HC based on the multivariate analysis.The Kaplan–Meier survival analysis showed no significant difference between the HC and non-HC groups(P=0.14).The 1-and 2-year survival rates in the HC group were 78.4%and 69.6%,respectively,and the corresponding rates in the non-HC group were 84.4%and 80.7%,respectively.ROC analysis indicated that a urine BKV load of 1×10^(7) copies/mL was able to stratify the risk of HC.In conclusion,when the BKV load is>1×10^(7),we needtobe aware of the potential for the development of HC.Biao Shen Yueshen Ma Haixiao Zhang Mingyang Wang Jia Liu Jiaxin Cao Wenwen Guo Dan Feng Donglin Yang Rongli Zhang Xin Chen Qiaoling Ma Weihua Zhai Sizhou Feng Mingzhe Han Aiming Pang Erlie Jiang 2022Blood Science2022,4,2:2
13NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition显示文摘NES1 gene is thought to be a tumor-suppressor gene.Our previous study found that overexpression of NES1 gene in PC3 cell line could slow down the tumor proliferation rate,associated with a mild decrease in BCL-2 expression.The BCL-2 decrease could increase the sensitivity of radiotherapy to tumors.Thus,we supposed to have an“enhanced firepower”effect by combining overexpressed NES1 gene therapy and 131I radiation therapy uptake by overexpressed hNIS protein.We found a weak endogenous expression of hNIS protein in PC3 cells and demonstrated that the low expression of hNIS protein in PC3 cells might be the reason for the low iodine uptake.By overexpressing hNIS in PC3,the radioactive iodine uptake ability was significantly increased.Results of in vitro and in vivo tumor proliferation experiments and 18F-fluorothymidine(18F-FLT)micro-positron emission tomography/computed tomography(micro-PET/CT)imaging showed that the combined NES1 gene therapy and 131I radiation therapy mediated by overexpressed hNIS protein had the best tumor proliferative inhibition effect.Immunohistochemistry showed an obvious decrease of Ki-67 expression and the lowest BCL-2 expression.These data suggest that via inhibition of BCL-2 expression,overexpressed NES1 might enhance the effect of radiation therapy of 131I uptake in hNIS overexpressed PC3 cells.Jiajia Hu Wenbin Shen Qian Qu Xiaochun Fei Ying Miao Xinyun Huang Jiajun Liu Yingli Wu Biao Li 2019Frontiers of Medicine2019,13,6:1
14Isolation of Bacillus amyloliquefaciens S20 and its application in control of eggplant bacterial wilt显示文摘Da Chen Xin liu Chunyu Li Wei Tian Qirong Shen Biao Shen 2014Journal of Environmental Management2014,,:1
15Diet habits, alcohol drinking, tobacco smoking, green tea drinking, and the risk of esophageal squamous cell carcinoma in the Chinese population显示文摘Jian Ming Wang Biao Xu Jian Yu Rao Hong Bing Shen Heng Chuan Xue Qing Wu Jiang 2007European Journal of Gastroenterology & Hepatology2007,,2:1
16Lower Bounds for the Minimum Eigenvtlue of Hadamard Product of an M - matrix and its Inverse 显示文摘Li Hou - biao Huang Ting - zhu Shen Shu - qian 2007Linear Algebra Appl2007,,420:1
17Evaluation of metoprolol standard dosing pathway in Chinese patients with acute coronary syndrome:a prospective multicenter single-arm interventional study显示文摘OBJECTIVE To evaluate the feasibility and tolerability of metoprolol standard dosing pathway(MSDP)in Chinese patients with acute coronary syndrome(ACS).METHODS In this multicenter,prospective,open label,single-arm and interventional study that was conducted from February 2018 to April 2019 in fifteen Chinese hospitals.A total of 998 hospitalized patients aged≥18 years and diagnosed with ACS were included.The MSDP was applied to all eligible ACS patients based on the standard treatment recommended by international guidelines.The primary endpoint was the percentage of patients achieving the target dose at discharge(V2).The secondary endpoints included the heart rate and blood pressure at V2 and four weeks after discharge(V4),and percentage of patients experiencing bradycardia(heart rate<50 beats/min),hypotension(blood pressure<90/60 mmHg)and transient cardiac dysfunction at V2 and V4.RESULTS Of the 998 patients,29.46%of patients achieved the target dose(≥95 mg/d)at V2.The total population was divided into two groups:target group(patients achieving the target dose at V2)and non-target group(patients not achieving the target dose at V2).There was significant difference in the reduction of heart rate from baseline to discharge in the two groups(-4.97±11.90beats/min vs.-2.70±9.47 beats/min,P=0.034).There was no significant difference in the proportion of bradycardia that occurred in the two groups at V2(0 vs.0,P=1.000)and V4(0.81%vs.0.33%,P=0.715).There was no significant difference in the proportion of hypotension between the two groups at V2(0.004%vs.0.004%,P=1.000)and V4(0 vs.0.005%,P=0.560).No transient cardiac dysfunction occurred in two groups during the study.A total of five adverse events(1.70%)and one serious adverse event(0.34%)were related to the pathway in target group.CONCLUSIONS In Chinese ACS patients,the feasibility and tolerability of the MSDP have been proved to be acceptable.Xiao-Yun YIN Yun-Mei ZHANG Ai-Dong SHEN Jing-Ping WANG Zhe-Xun LIAN Yi-Bing SHAO Wen-Qi ZHANG Shu-Ying ZHANG Yang ZHENG Kang CHENG Biao XU Cheng-Xing SHEN Rong-Chong HUANG Jin-Cheng GUO Guo-Sheng FU Dong-Kai SHAN Dan-Dan LI Yun-Dai CHEN 2023Journal of Geriatric Cardiology2023,20,4:1
18Detection of free surface composition and molecular-level structural development of styrene(S)/butadiene(B) block copolymer films during a solution-to-film process显示文摘The surface chemical structure development in solution-cast styrene(S)/butadiene(B) block copolymer films as a function of solvent evaporation time was investigated using sum frequency generation vibrational spectroscopy(SFG).The surface structure formation of the styrene(S)/butadien(B) block copolymer(30 wt% PS) films during the solution-to-film process was found to be controlled mainly by dynamic factors,such as the mobility of the PB block in solution.For SB diblock copolymers,a pure PB surface layer was formed only when the film was cast by dilute toluene solution.With increasing concentration of casting solution,PB and PS components were found to coexist on the film surface,and the morphology of the PB component on the film surface changed from cylindrical rods to spheres.For SBS triblock copolymers,a small amount of PS component existed on the surface even if the film was cast by 1.0 wt% toluene solution.In addition,PS components at the outermost layer of the film increased and the length of PB cylindrical rods on the surface decreased with increasing concentration of casting solution.YAN ZhuoHua ZHANG RongPing ZHAO YuRong ZUO Biao ZHENG FanFan CHEN TianYu WANG XinPing SHEN ZhiQuan 2012Science China Chemistry2012,55,7:1
19Extraction,structure and bioactivities of the polysaccharides from Fructus comi显示文摘WU Yanfang WANG Xinsheng SHEN Biao 2013Recent Patents on Food Nutrition & Agriculture2013,5,1:1
20Isolation and characterization of Pseudomonas brassicacearum J12 as an antagonist against Ralstonia solanacearum and identification of its antimicrobial components显示文摘Tiantian Zhou Da Chen Chunyu Li Qian Sun Lingzhi Li Fang Liu Qirong Shen Biao Shen 2012Microbiological Research2012,,7:1
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