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| 1 | T cell-depleting nanoparticles ameliorate bone loss by reducing activated T cells and regulating the Treg/Th17 balance显示文摘Estrogen deficiency is one of the most frequent causes of osteoporosis in postmenopausal women.Under chronic inflammatory conditions caused by estrogen deficiency,activated T cells contribute to elevated levels of proinflammatory cytokines,impaired osteogenic differentiation capabilities of bone marrow mesenchymal stem cells(BMMSCs),and disturbed regulatory T cell(Treg)/Th17 cell balance.However,therapeutic strategies that re-establish immune homeostasis in this disorder have not been well developed.Here,we produced T cell-depleting nanoparticles(TDNs)that ameliorated the osteopenia phenotype and rescued the osteogenic deficiency of BMMSCs in ovariectomized(OVX)mice.TDNs consist of monocyte chemotactic protein-1(MCP-1)-encapsulated mesoporous silica nanoparticles as the core and Fas-ligand(FasL)as the corona.We showed that the delicate design of the TDNs enables rapid release of MCP-1 to recruit activated T cells and then induces their apoptosis through the conjugated FasL both in vitro and in vivo.Apoptotic signals recognized by macrophages help skew the Treg/Th17 cell balance and create an immune tolerant state,further attenuating the osteogenic deficiency of BMMSCs and the osteopenia phenotype.Mechanistically,we found that the therapeutic effects of TDNs were partially mediated by apoptotic T cell-derived extracellular vesicles(ApoEVs),which promoted macrophage transformation towards the M2 phenotype.These findings demonstrate that TDNs may represent a promising strategy for treating osteoporosis and other immune disorders. | Xiaoshan Yang Fuxing Zhou Pingyun Yuan Geng Dou Xuemei Liu Siying Liu Xiangdong Wang Ronghua Jin Yan Dong Jun Zhou Yajie Lv Zhihong Deng Shiyu Liu Xin Chen Ying Han Yan Jin | 2021 | Bioactive Materials2021，6，10： | 4 |
| 2 | Clinical characteristics of 19 neonates born to mothers with COVID-19显示文摘The aim of this study was to investigate the clinical characteristics of neonates born to SARS-CoV-2 infected mothers and increase the current knowledge on the perinatal consequences of COVID-19.Nineteen neonates were admitted to Tongji Hospital from January 31 to February 29,2020.Their mothers were clinically diagnosed or laboratory-confirmed with COVID-19.We prospectively collected and analyzed data of mothers and infants.There are 19 neonates included in the research.Among them,10 mothers were confirmed COVID-19 by positive SARS-CoV-2 RT-PCR in throat swab,and 9 mothers were clinically diagnosed with COVID-19.Delivery occurred in an isolation room and neonates were immediately separated from the mothers and isolated for at least 14 days.No fetal distress was found.Gestational age of the neonates was 38.61.5 weeks,and average birth weight was 3293425 g.SARS-CoV-2 RT-PCR in throat swab,urine,and feces of all neonates were negative.SARS-CoV-2 RT-PCR in breast milk and amniotic fluid was negative too.None of the neonates developed clinical,radiologic,hematologic,or biochemical evidence of COVID-19.No vertical transmission of SARS-CoV-2 and no perinatal complications in the third trimester were found in our study.The delivery should occur in isolation and neonates should be separated from the infected mothers and care givers. | Wei Liu Jing Wang Wenbin Li Zhaoxian Zhou Siying Liu Zhihui Rong | 2020 | Frontiers of Medicine2020，14，2： | 3 |
| 3 | Engineered neutrophil apoptotic bodies ameliorate myocardial infarction by promoting macrophage efferocytosis and inflammation resolution显示文摘Inflammatory response plays a critical role in myocardial infarction(MI)repair.The neutrophil apoptosis and subsequent macrophage ingestion can result in inflammation resolution and initiate regeneration,while the therapeutic strategy that simulates and enhances this natural process has not been established.Here,we constructed engineered neutrophil apoptotic bodies(eNABs)to simulate natural neutrophil apoptosis,which regulated inflammation response and enhanced MI repair.The eNABs were fabricated by combining natural neutrophil apoptotic body membrane which has excellent inflammation-tropism and immunoregulatory properties,and mesoporous silica nanoparticles loaded with hexyl 5-aminolevulinate hydrochloride(HAL).The eNABs actively targeted to macrophages and the encapsulated HAL simultaneously initiated the biosynthesis pathway of heme to produce anti-inflammatory bilirubin after intracellular release,thereby further enhancing the anti-inflammation effects.In in vivo studies,the eNABs efficiently modulated inflammation responses in the infarcted region to ameliorate cardiac function.This study demonstrates an effective biomimetic construction strategy to regulate macrophage functions for MI repair. | Lili Bao Geng Dou Ran Tian Yajie Lv Feng Ding Siying Liu Ruifeng Zhao Lu Zhao Jun Zhou Lin Weng Yan Dong Bei Li Shiyu Liu Xin Chen Yan Jin | 2022 | Bioactive Materials2022，7，3： | 3 |
| 4 | Dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles显示文摘Tooth decay is prevalent,and secondary caries causes restoration failures,both of which are related to demineralization.There is an urgent need to develop new therapeutic materials with remineralization functions.This article represents the first review on the cutting edge research of poly(amido amine)(PAMAM) in combination with nanoparticles of amorphous calcium phosphate (NACP).PAMAM was excellent nucleation template,and could absorb calcium (Ca) and phosphate (P) ions via its functional groups to activate remineralization.NACP composite and adhesive showed acid-neutralization and Ca and P ion release capabilities.PAMAM +NACP together showed synergistic effects and produced triple benefits: excellent nucleation templates,superior acidneutralization,and ions release.Therefore,the PAMAM+NACP strategy possessed much greater remineralization capacity than using PAMAM or NACP alone.PAMAM+NACP achieved dentin remineralization even in an acidic solution without any initial Ca and P ions.Besides,the long-term remineralization capability of PAMAM+NACP was established.After prolonged fluid challenge,the immersed PAMAM with the recharged NACP still induced effective dentin mineral regeneration.Furthermore,the hardness of predemineralized dentin was increased back to that of healthy dentin,indicating a complete remineralization.Therefore,the novel PAMAM+NACP approach is promising to provide long-term therapeutic effects including tooth remineralization,hardness increase,and caries-inhibition capabilities. | Kunneng Liang Suping Wang Siying Tao Shimeng Xiao Han Zhou Ping Wang Lei Cheng Xuedong Zhou Michael D.Weir Thomas W.Oates Jiyao Li Hockin H.K.Xu | 2019 | International Journal of Oral Science2019，11，3： | 3 |
| 5 | The biogeographical distribution of tree species-abundance and its relation to climatic factors in mass islands显示文摘Tree species-abundance in forests is a function of geographical area and climate, although it is not clear whether such relationships apply to mass islands. We examined the spatial pattern of tree species in mass islands along the coast of Zhejiang, East China Sea using the Preston model, to identify the relationships between tree communities and climatic conditions. The results show that:(1) the biogeographical distribution of tree species-abundance conformes to Preston's log-normal pattern, and is in accordance with the findings in both tropical rainforests and estuarine forests;(2) the climatic factors related to tree communities in mass islands are similar to that of the subtropical zone, including the major species of evergreen needle-leaf, broad-leaf and deciduous broad-leaf forests. We conclude that the Preston model can be applied to the trees of mass islands and thus facilitate the systematic ecological researches of vegetation species' composition in subtropical zone. | LI Xiaoming WU Chengzhen GU Wu YE Ran ZHANG Haibo QI Ping WANG Shengqiang ZHOU Siying WEI Yongjie CAI Yanhong | 2017 | Acta Oceanologica Sinica2017，36，9： | 1 |
| 6 | Constructing Pd-N interactions in Pd/g-C_(3)N_(4)to improve the charge dynamics for efficient photocatalytic hydrogen evolution显示文摘The formation of chemical bonds between metal ions and their supports is an effective strategy to achieve good catalytic activity.However,both the synthesis of active metal species on a support and control of their coordination environment are still challenging.Here,we show the use of an organic compound to produce tubular carbon nitride(TCN)as a support for Pd nanoparticles(NPs),creating a composite material(NP-Pd-TCN).It was found that Pd ions preferentially bind with the electron-rich N atoms of TCN,leading to strong metal-support interactions that benefit charge transfer from g-C_(3)N_(4)to Pd.X-ray absorption spectroscopy further revealed that the metal-support interactions resulted in the formation of Pd-N bonds,which are responsible for the improvement in the charge dynamics as evidenced by the results from various techniques including photoluminescence(PL)spectroscopy,photocurrent measurements,and electrochemical impedance spectroscopy(EIS).Owing to the good dynamical properties,NP-Pd-TCN was used for photocatalytic hydrogen evolution under visible-light irradiation(λ>420 nm)and an excellent evolution rate of~381μmol·h^(-1)(0.02 g of the photocatalyst)was attained.This work aims to promote a strategy to synthesize efficient photocatalysts for hydrogen production by controllably introducing metal nanoparticles on a support and in the meantime forming chemical bonds to achieve intimate metal-support contact. | Xudong Xiao Siying Lin Liping Zhang Huiyuan Meng Jing Zhou Qi Li Jianan Liu Panzhe Qiao Baojiang Jiang Honggang Fu | 2022 | Nano Research2022，15，4： | 1 |
| 7 | Mid1ip1b modulates apical reorientation of non-centrosomal microtubule organizing center in epithelial cells显示文摘In most kinds of animal cells,the centrosome serves as the main microtubule organizing center(MTOC)that nucleates microtubule arrays throughout the cytoplasm to maintain cell structure,cell division and intracellular transport.Whereas in epithelial cells,non-centrosomal MTOCs are established in the apical domain for generating asymmetric microtubule fibers and cilia in epithelial cells for the organ morphogenesis during embryonic development.However,the mechanism by which MTOCs localize to the apical domain in epithelial cells remains largely unknown.Here,we show that Mid1ip1b has a close interaction with g-tubulin protein,the central component of MTOC,and modulates lumen opening of the neural tube,gut,intestine,and kidney of zebrafish.Knockdown or dominant negative effect of Mid1ip1b resulted in failure of lumen formation of the organs as aforementioned.Moreover,the non-centrosomal MTOCs were unable to orientate to the apical domain in Mid1ip1b knockdown epithelial cells,and the centrosomal MTOCs were inaccurately placed in the apical domain,resulting in defective formation of asymmetric microtubules and misplacement of cilia in the apical domain.These data uncover a molecule that controls the proper localization of MTOCs in the apical domain in epithelial cells for organ morphogenesis during embryonic development. | Xin Zhou Chun Xiao Yu Li Yanna Shang Dongqin Yin Siying Li Bo Xiang Ran Lu Yi Ji Yang Wu Wentong Meng Hongyan Zhu Jin Liu Huozhen Hu Xianming Mo Hong Xu | 2018 | Journal of Genetics and Genomics2018，45，8： | 0 |
| 8 | A Generalized Polymer Precursor Ink Design for 3D Printing of Functional Metal Oxides显示文摘Three-dimensional-structured metal oxides have myriad applications for optoelectronic devices.Comparing to conventional lithography-based manufacturing methods which face significant challenges for 3D device architectures,additive manufacturing approaches such as direct ink writing offer convenient,on-demand manufacturing of 3D oxides with high resolutions down to sub-micrometer scales.However,the lack of a universal ink design strategy greatly limits the choices of printable oxides.Here,a universal,facile synthetic strategy is developed for direct ink writable polymer precursor inks based on metal-polymer coordination effect.Specifically,polyethyleneimine functionalized by ethylenediaminetetraacetic acid is employed as the polymer matrix for adsorbing targeted metal ions.Next,glucose is introduced as a crosslinker for endowing the polymer precursor inks with a thermosetting property required for 3D printing via the Maillard reaction.For demonstrations,binary(i.e.,ZnO,CuO,In_(2)O_(3),Ga_(2)O_(3),TiO_(2),and Y_(2)O_(3)) and ternary metal oxides(i.e.,BaTiO_(3) and SrTiO_(3)) are printed into 3D architectures with sub-micrometer resolution by extruding the inks through ultrafine nozzles.Upon thermal crosslinking and pyrolysis,the 3D microarchitectures with woodpile geometries exhibit strong light-matter coupling in the mid-infrared region.The design strategy for printable inks opens a new pathway toward 3D-printed optoelectronic devices based on functional oxides. | Hehao Chen Jizhe Wang Siying Peng Dongna Liu Wei Yan Xinggang Shang Boyu Zhang Yuan Yao Yue Hui Nanjia Zhou | 2023 | Nano-Micro Letters2023，15，10： | 0 |
| 9 | Fetuin-A is an immunomodulator and a potential therapeutic option in BMP4-dependent heterotopic ossification and associated bone mass loss显示文摘Heterotopic ossification(HO)is the abnormal formation of bone in extraskeletal sites.However,the mechanisms linking HO pathogenesis with bone mass dysfunction remain unclear.Here,we showed that mice harboring injury-induced and BMP4-dependent HO exhibit bone mass loss similar to that presented by patients with HO.Moreover,we found that injury-induced hyperinflammatory responses at the injury site triggered HO initiation but did not result in bone mass loss at 1 day post-injury(dpi).In contrast,a suppressive immune response promoted HO propagation and bone mass loss by 7 dpi.Correcting immune dysregulation by PD1/PDL1 blockade dramatically alleviated HO propagation and bone mass loss.We further demonstrated that fetuin-A(FetA),which has been frequently detected in HO lesions but rarely observed in HO-adjacent normal bone,acts as an immunomodulator to promote PD1 expression and M2 macrophage polarization,leading to immunosuppression.Intervention with recombinant FetA inhibited hyperinflammation and prevented HO and associated bone mass loss.Collectively,our findings provide new insights into the osteoimmunological interactions that occur during HO formation and suggest that FetA is an immunosuppressor and a potential therapeutic option for the treatment of HO. | Chen Kan Jiazhao Yang Haitao Fan Yuanjuan Dai Xingxing Wang Rui Chen Jia Liu Xiangyue Meng Wei Wang Guiling Li Jiao Zhou Ya Zhang Wanbo Zhu Shiyuan Fang Haiming Wei Hong Zheng Siying Wang Fang Ni | 2022 | Bone Research2022，10，4： | 0 |
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