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| 1 | Boron neutron capture therapy for malignant melanoma: first clinical case report in China显示文摘A phase Ⅰ/Ⅱ clinical trial for treating malignant melanoma by boron neutron capture therapy(BNCT) was designed to evaluate whether the world's first in-hospital neutron irradiator(IHNI) was qualified for BNCT. In this clinical trial planning to enroll 30 patients, the first case was treated on August 19, 2014. We present the protocol of this clinical trial, the treating procedure, and the clinical outcome of this first case. Only grade 2 acute radiation injury was observed during the first four weeks after BNCT and the injury healed after treatment. No late radiation injury was found during the 24-month follow-up. Based on positron emission tomography-computed tomography(PET/CT) scan, pathological analysis and gross examination, the patient showed a complete response to BNCT,indicating that BNCT is a potent therapy against malignant melanoma and IHNI has the potential to enable the delivery of BNCT in hospitals. | Zhong Yong Zewen Song Yongmao Zhou Tong Liu Zizhu Zhang Yanzhong Zhao Yang Chen Congjun Jin Xiang Chen Jianyun Lu Rui Han Pengzhou Li Xulong Sun Guohui Wang Guangqing Shi Shaihong Zhu | 2016 | Chinese Journal of Cancer Research2016，28，6： | 13 |
| 2 | Combined peripheral natural killer cell and circulating tumor cell enumeration enhance prognostic efficiency in patients with metastatic triple-negative breast cancer显示文摘Objective:Triple-negative breast cancer(TNBC)is a heterogeneous disease with poor prognosis.Circulating tumor cells(CTCs)are a promising predictor for breast cancer prognoses but their reliability regarding progression-free survival(PFS)is controversial.We aim to verify their predictive value in TNBC.Methods:In present prospective cohort study,we used the Pep@MNPs method to enumerate CTCs in baseline blood samples from 75 patients with TNBC(taken at inclusion in this study)and analyzed correlations between CTC numbers and outcomes and other clinical parameters.Results:Median PFS was 6.0(range:1.0–25.0)months for the entire cohort,in whom we found no correlations between baseline CTC status and initial tumor stage(P=0.167),tumor grade(P=0.783)or histological type(P=0.084).However,among those getting first-line treatment,baseline CTC status was positively correlated with ratio of peripheral natural killer(NK)cells(P=0.032),presence of lung metastasis(P=0.034)and number of visceral metastatic site(P=0.037).Baseline CTC status was predictive for PFS in first-line TNBC(P=0.033),but not for the cohort as a whole(P=0.118).This prognostic limitation of CTC could be ameliorated by combining CTC and NK cell enumeration(P=0.049).Conclusions:Baseline CTC status was predictive of lung metastasis,peripheral NK cell ratio and PFS in TNBC patients undergoing first-line treatment.We have developed a combined CTC-NK enumeration strategy that allows us to predict PFS in TNBC without any preconditions. | Xiaoran Liu Ran Ran Bin Shao Hope S.Rugo Yanlian Yang Zhiyuan Hu Zewen Wei Fengling Wan Weiyao Kong Guohong Song Hanfang Jiang Xu Liang Ruyan Zhang Ying Yan Guobing Xu Huiping Li | 2018 | Chinese Journal of Cancer Research2018，30，3： | 4 |
| 3 | Quantitative assessment of gas washing of oils in the Tazhong area of the Tarim Basin,Northwest China显示文摘Gas washing has been known in the Tazhong area of the Tarim Basin,but its quantitative assessment has not yet been reported.Here the influence of gas washing fractionation in the area was discussed based on the gas chromatogram data of 68 oils and the results of the mixing experiments of a black oil and a condensate.The results show that the intensity of gas washing fractionation decreased generally from northern to southern part and vertically from deep reservoirs to shallow reservoirs.The gas washing fractionation was mainly controlled by fault systems in this area,with the increase of n-alkane mass depletion positively correlated to the number and scale of faults.Gas washing fractionation appears to have affected the hydrocarbon property,and as a result the diversity of the crude oils is markedly controlled by gas washing.In addition,the occurrence of waxy oil in this area may be resulted from multiple factors including gas washing,mixed filling and migration fractionation. | YANG ChuPeng GENG AnSong LIAO ZeWen SUN YongGe ZHANG LüHui | 2009 | Science China Earth Sciences2009，52，1： | 4 |
| 4 | Intercomparison of GPS radiosonde soundings during the eastern tropical Indian Ocean experiment显示文摘Temperature and relative humidity profiles derived from two China-made global positioning system(GPS)radiosondes(GPS-TK and CF-06-A)during the east tropical Indian Ocean(ETIO)experiment were compared with Vaisala RS92-SGP to assess the performances of China-made radiosondes over the tropical ocean.The results show that there have relative large biases in temperature observations between the GPSTK and the RS92-SGP in the low troposphere,with a warm bias of greater than 2 K in the day and a cooling bias of 0.6 K at night.The temperature differences of the CF-06-A were small in the troposphere both in daytime and nighttime,and became large peak-to-peak fluctuations in the stratosphere.The intercomparison of the relative humidity showed that the CF-06-A had large random errors due to the limitation of sensors and the lack of correction scheme,and the GPS-TK had large systematic biases in the low troposphere which might be related to the temperature impact.GPS height measurements are clearly suitable for China-made radiosonde systems operation.At night,the CF-06-A and the GPS-TK could provide virtual potential temperature and atmospheric boundary layer height measurements of suitable quality for both weather and climate research.As a result of the intercomparison experiment,major errors in the Chinamade radiosonde systems were well indentified and subsequently rectified to ensure improving accuracy for historical and future radiosondes. | XIE Qiang HUANG Ke WANG Dongxiao YANG Lei CHEN Ju WU Zewen LI Daning LIANG Zhiyan | 2014 | Acta Oceanologica Sinica2014，33，1： | 4 |
| 5 | Factors Affecting the Catalytic Performance of Nano-catalysts显示文摘Comprehensive Summary Nano-catalysis plays a vital role in the industrially chemical transformations.The increasingly severe energy crisis and environmental issues spur scientists to exploit novel nano-catalysts in diverse fields.It is essential to understand the fundamental physicochemical properties of nano-catalysts to develop efficient systems,whose design can be subsequently precisely tuned at the atomic level.In this review,we summarize several key factors affecting the catalytic activity of nano-catalysts,including structure,composition,size,and interface,providing guidance for the atomic level control of high-efficient nano-catalysts.Finally,we present a brief conclusion and some thoughts on nano-catalysis. | Hongling Yang Yue Wu Zewen Zhuang Yang Li Chen Chen | 2022 | Chinese Journal of Chemistry2022，40，4： | 3 |
| 6 | Multiple amino acid substitutions are involved in the adaptation of H9N2 avian influenza virus to mice显示文摘 | Rui Wu Hongbo Zhang Keli Yang Wangwang Liang Zhongliang Xiong Zewen Liu Xuehai Yang Huabin Shao Xinmin Zheng Mingxin Chen Diping Xu | 2009 | Veterinary Microbiology2009，，1： | 1 |
| 7 | Some biogenic-related compounds occluded inside asphaltene ag- gregates显示文摘 | Yang Chupeng Liao Zewen Zhang Lfihui Creux P | 2009 | Energy Fuel2009，23，2： | 1 |
| 8 | Stable isotope(δ^(13)C_(ker),δ^(13)C_(carb),δ^(18)O_(carb)) distribution along a Cambrian outcrop section in the eastern Tarim Basin,NW China and its geochemical significance显示文摘This study investigated the geochemical features of the lower Paleozoic strata of Yaerdang Mountain outcrop along with the core samples from well TD2∈ in the eastern Tarim Basin,NW China.The total organic carbon abundance,hydrocarbon-generating precursor biospecies,and stable isotope ratios of organics and carbonate(δ^(13)C_(ker),δ^(13)C_(carb) and δ^(18)O_(carb)) were comprehensively studied for their possible correlative constraints during sedimentary evolution.The results revealed that the δ^(13)C_(ker)(VPDB) of Cambrian kerogens along the outcrop section varied from-34.6‰ to-28.4‰,indicating an increasing tendency from the lower Cambrian to the upper Cambrian.This was on the whole accompanied by the variation in the δ^(13)C_(carb) and δ^(18)O_(carb) along the profile,which might be associated with the changes in the sea level and also in the compositional variation of benthic and planktonic biomass.The large variation in the stable carbon isotope ratios up to 6‰ along the outcrop section reflected the heterogeneity of the Cambrian source rocks from the eastern Tarim Basin.Hence,the ^(13)C-enriched crude oils from well TD2∈might have been derived from a localized stratum of Cambrian source rocks.The results from this study showed the possibility of multiple source kitchens in the Cambrian-lower Ordovician portion of Tarim Basin. | Hu Liu Zewen Liao Haizu Zhang Yankuan Tian Bin Cheng Shan Yang | 2017 | Geoscience Frontiers2017，8，1： | 1 |
| 9 | Comparative studies on compounds occluded inside asphaltenes hierarchically released by increasing amounts of H202/CH3COOH显示文摘 | Zhao Jing Liao Zewen Zhang Lfihui Creux R Yang Chupeng Chrostowska A Zhang Haizu Graciaa A | 2010 | Appl Geochem2010，25，9： | 1 |
| 10 | Multiple-sourced features of marine oilsin the Tarim Basin, NW China - Geochemical evidencefrom occluded hydrocarbons inside asphaltenes 显示文摘 | Tian Yankuan Zhao Jing Yang Chupeng Liao Zewen ZhangLühui Zhang Haizu | 2012 | J AsianEarth Sci2012，5455，17： | 1 |
| 11 | Geochemical quantification of mixed marine oils fromTazhong Area of Tarim Basin, NW China 显示文摘 | Tian Yankuan Yang Chupeng Liao Zewen Zhang Haizu | 2012 | J Pet Sci Eng2012，9091，96： | 1 |
| 12 | Cuticular compounds inhibit cannibalism of early-instar spiderlings by pulli-carrying Pardosa pseudoannulata females显示文摘Cannibalism is common in spiders.Wolf spider(Lycosidae)females,which exhibit extensive maternal care,have been reported to cannibalize less when they are carrying egg sacs and juveniles.In a laboratory experiment,we demonstrated that cannibalism of early-instar spiderlings(EIS)by a wolf spider(Pardosa pseudoannulata)mother was almost completely inhibited when she was carrying spiderlings.Compared with virgin and mated-females,mother spiders tolerated more and predated fewer spiderlings,including gregarious pulli and newly dispersed spiderlings(NDS).Cannibalism of EIS by females during their reproductive period exhibited a V-shaped pattern,with a gradual decrease from the egg sac-carrying to pulli-carrying(PC)stage,and a recovery from the PC stage to post-reproductive(PR)stage.Notably,there was 0 cannibalism at the PC stage.PC females exhibited no interest in pulli,while PR females were attracted to and predated pulli and NDS as they did their natural prey,Nilaparvata lugens.Interestingly,PC females captured and released NDS in a foraging assay,although attraction was observed from olfactometer measurements.PC mothers possessed a cuticular volatile profile that was closer to that of pulli and NDS than to that of PR females.Moreover,NDS cuticular extract provoked an electrophysiological response in legs of PC females.Therefore,cuticular compound-mediated chemical communication may be involved in inhibiting cannibalism of EIS by spider mothers,and especially in eliminating cannibalism by PC mothers.Future studies will aim to characterize the specific cuticular compounds and chemoreception mechanism in females,which will facilitate our understanding of intraspecific recognition and cannibalism in spiders. | Na Yu Yunru Chen Guangming Xu Zhiming Yang Shijie Wang Tianyu Lu Yixi Zhang Zewen Liu | 2022 | Insect Science2022，29，5： | 0 |
| 13 | Light-driven soft actuator based on graphene and WSe2 nanosheets composite for multimodal motion and remote manipulation显示文摘Remote controlled soft actuators have attracted ever-increasing interest in industrial,medical,robotics,and engineering fields.Soft actuators are charming than normal tools in executing dedicate tasks due to small volume and flexible body they have.However,it remains a challenge to design soft actuator that can adapt to multi-environments under remote stimuli with promising nano materials.Herein,we have developed a kind of near-infrared laser driven soft actuators with multi locomotive modes based on WSe2 and graphene nanosheets heterojunction.Different locomotion modes are driven by photothermal effect induced deformation to adapt to different working conditions.Moreover,the specially designed gripper driven by pulsed laser can lift a heavy load which is four times of its weight.This work broadens the choice of advanced nanomaterials for photothermal conversion of soft actuators.It is promising to realize applications including photothermal therapy and complex environment detection through the combination of the intelligent robot design and optical fiber system. | Zewen Su Yingjie Zhao Youqiang Huang Chaoyue Xu Xiaolei Yang Binrui Wang Beibei Xu Shiqing Xu Gongxun Bai | 2023 | Nano Research2023，16，1： | 0 |
| 14 | Scattering Inversion Study for Suspended Label-Free Lymphocytes with Complex Fine Structures显示文摘Objective and Impact Statement.Distinguishing malignant lymphocytes from normal ones is vital in pathological examination.We proposed an inverse light scattering(ILS)method for label-free suspended lymphocytes with complex fine structures to identify their volumes for pathological state.Introduction.Light scattering as cell’s“fingerprint”provides valuable morphology information closely related to its biophysical states.However,the detail relationships between the morphology with complex fine structures and its scattering characters are not fully understood.Methods.To quantitatively inverse the volumes of membrane and nucleus as the main scatterers,clinical lymphocyte morphologies were modeled combining the Gaussian random sphere geometry algorithm by 750 reconstructed results after confocal scanning,which allowed the accurate simulation to solve ILS problem.For complex fine structures,the specificity for ILS study was firstly discussed(to our knowledge)considering the differences of not only surface roughness,posture,but also the ratio of nucleus to the cytoplasm and refractive index.Results.The volumes of membrane and nucleus were proved theoretically to have good linear relationship with the effective area and entropy of forward scattering images.Their specificity deviations were less than 3.5%.Then,our experimental results for microsphere and clinical leukocytes showed the Pearson product-moment correlation coefficients(PPMCC)of this linear relationship were up to 0.9830~0.9926.Conclusion.Our scattering inversion method could be effectively applied to identify suspended label-free lymphocytes without destructive sample pretreatments and complex experimental systems. | Lu Zhang Huijun Wang Jianyi Liu Shuang Chen He Yang Zewen Yang Zhenxi Zhang Hong Zhao Li Yuan Lifang Tian Bo Zhong Xiaolong Liu | 2022 | Biomedical Engineering Frontiers2022，3，1： | 0 |
| 15 | Increased long-distance and homo-trans interactions related to H3K27me3 in Arabidopsis hybrids显示文摘In plants,the genome structure of hybrids changes compared with their parents,but the effects of these changes in hybrids remain elusive.Comparing reciprocal crosses between Col×C24 and C24×Col in Arabidopsis using high-throughput chromosome conformation capture assay(Hi-C)analysis,we found that hybrid three-dimensional(3D)chromatin organization had more long-distance interactions relative to parents,and this was mainly located in promoter regions and enriched in genes with heterosis-related pathways.The interactions between euchromatin and heterochromatin were increased,and the compartment strength decreased in hybrids.In compartment domain(CD)boundaries,the distal interactions were more in hybrids than their parents.In the hybrids of CURLY LEAF(clf)mutants clfCol×clfC24and clfC24×clfCol,the heterosis phenotype was damaged,and the long-distance interactions in hybrids were fewer than in their parents with lower H3K27me3.ChIP-seq data revealed higher levels of H3K27me3 in the region adjacent to the CD boundary and the same interactional homo-trans sites in the wild-type(WT)hybrids,which may have led to more long-distance interactions.In addition,the differentially expressed genes(DEGs)located in the boundaries of CDs and loop regions changed obviously in WT,and the functional enrichment for DEGs was different between WT and clf in the longdistance interactions and loop regions.Our findings may therefore propose a new epigenetic explanation of heterosis in the Arabidopsis hybrids and provide new insights into crop breeding and yield increase. | Zhaoxu Gao Yanning Su Le Chang Guanzhong Jiao Yang Ou Mei Yang Chao Xu Pengtao Liu Zejia Wang Zewen Qi Wenwen Liu Linhua Sun Guangming He Xing Wang Deng Hang He | 2024 | Journal of Integrative Plant Biology2024，66，2： | 0 |
| 16 | Switchable Kirigami Structures as Window Envelopes for Energy-Efficient Buildings显示文摘Efficient regulation of thermal radiation is an effective way to conserve energy consumption of buildings.Because windows are the least energy-efficient part of buildings,their thermal radiation regulation is highly demanded,especially in the changing environment,but is still a challenge.Here,by employing a kirigami structure,we design a variable-angle thermal reflector as a transparent envelope of windows for their thermal radiation modulation.The envelope can be easily switched between heating and cooling modes by loading different pre-stresses,which endow the envelope windows with the ability of temperature regulation,and the interior temperature of a building model can be reduced by~3.3°C under cooling mode and increased by~3.9°C under heating mode in the outdoor test.The improved thermal management of windows by the adaptive envelope provides an extra heating,ventilation,and air-conditioning energy savings percentage of 13%to 29%per year for buildings located in different climate zones around the world,making the kirigami envelope windows a promising way for energy-saving utilization. | Hanzhi Yin Xishu Zhou Zhengui Zhou Rong Liu Xiwei Mo Zewen Chen Erqi Yang Zhen Huang Hao Li Hao Wu Jun Zhou Yi Long Bin Hu | 2023 | Research2023，，4： | 0 |
| 17 | Building Better Full Manganese‑Based Cathode Materialsfor Next‑Generation Lithium‑Ion Batteries显示文摘Lithium-manganese-oxides have been exploited as promising cathode materials for many years due to their environmental friendliness,resource abundance and low biotoxicity.Nevertheless,inevitable problems,such as Jahn-Teller distortion,manganese dissolution and phase transition,still frustrate researchers;thus,progress in full manganese-based cathode materials(FMCMs)has been relatively slow and limited in recent decades.Recently,with the fast growth of vehicle electrification and large-scale energy-storage grids,there has been an urgent demand to develop novel FMCMs again;actually,new waves of research based on FMCMs are being created.Herein,we systematically review the history of FMCMs,correctly describe their structures,evaluate the advantages and challenges,and discuss the resolution strategies and latest developments.Additionally,beyond FMCMs,a profound discussion of current controversial issues,such as oxygen redox reaction,voltage decay and voltage hysteresis in Li_(2)MnO_(3)-based cathode materials,is also presented.This review summarizes the effectively optimized approaches and offers a few new possible enhancement methods from the perspective of the electronic-coordination-crystal structure for building better FMCMs for next-generation lithium-ion batteries. | Jin Song Hangchao Wang Yuxuan Zuo Kun Zhang Tonghuan Yang Yali Yang Chuan Gao Tao Chen Guang Feng Zewen Jiang Wukun Xiao Tie Luo Dingguo Xia | 2023 | Electrochemical Energy Reviews2023，6，1： | 0 |
| 18 | Comparative Study of the Effects of Nano ZnO and CuO on the Biodegradation,Biocompatibility,and Antibacterial Properties of Micro-arc Oxidation Coating of Magnesium Alloy显示文摘This research systematically examined the degradation,antibacterial effects,and biocompatibility of micro-arc oxidation(MAO)coatings with nano CuO and ZnO on extruded Mg alloys.Both copper(Cu)and Zinc(Zn)possess antibacterial properties.The findings demonstrated that adding ZnO will appreciably reduce the degradation rate of MAO-coating alloy due to the self-sealing micro holes.CuO+MAO coating exhibited excellent antibacterial performance,with an antibacterial rate of over 90%within 6 h co-cultured with Staphylococcus aureus.Similarly,the antibacterial rate of ZnO+MAO coating reached 90%after 12 h co-culture.Cytotoxicity test using MG63 cell indicated that the incorporation of CuO and ZnO did not notably affect the cell viability rate of the coating.Moreover,after 14 days of culture,the CuO+MAO and ZnO+MAO coated samples exhibited higher alkaline phosphatase(ALP)activity than the MAO-coated and uncoated samples,suggesting favorable osteogenic properties. | Ying Shen Xianfeng Shan Iniobong P.Etim Muhammad Ali Siddiqui Yang Yang Zewen Shi Xuping Su Junxiu Chen | 2024 | Acta Metallurgica Sinica(English Letters)2024，37，2： | 0 |
| 19 | Life Cycle Assessment Introduced by Using Nanorefrigerant of Organic Rankine Cycle System for Waste Heat Recovery显示文摘The use of nanorefrigerants in Organic Rankine Cycle(ORC)units is believed to affect the cycle environment performance,but backed with very few relevant studies.For this purpose,a life cycle assessment(LCA)has been performed for the ORC system using nanorefrigerant,the material and energy input,characteristic indicators and comprehensive index of environmental impact,total energy consumption and energy payback time(BPBT)of the whole life cycle of ORC system using Al_(2)O_(3)/R141b nanorefrigerant were calculated.Total environmental comprehensive indexes reveal that ECER-135 index decrease by 1.5%after adding 0.2%Al_(2)O_(3)nanoparticles to R141b.Based on the contribution analysis and sensitivity analysis,it can be found out ORC system manufacturing is of the most critical stage,where,the ECER-135 index of ORC component production is the greatest,followed by the preparation process of R141b,transportation phase,and that of Al_(2)O_(3)nanoparticles preparation is small.The retirement phase which has good environmental benefits affects the result significantly by recycling important materials.Meanwhile,the main cause and relevant suggestion for improvement were traced respectively.Finally,the environmental impacts of various power generations were compared,and results show that the power route is of obvious advantage.Among the renewable energy,ORC system using Al_(2)O_(3)/R141b nanorefrigerant with minimal environmental impact is only 0.67%of coal-fired power generation.The environmental impact of current work is about 14.34%of other nations’PV results. | Yuchen Yang Lin Ma Jie Yu Zewen Zhao Pengfei You | 2023 | Journal of Renewable Materials2023，11，3： | 0 |
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