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| 1 | Effect of minor Sc addition on microstructure and stress corrosion cracking behavior of medium strength Al–Zn–Mg alloy显示文摘Influence of Sc content on microstructure and stress corrosion cracking behavior of medium strength Al–Zn–Mg alloy have been investigated by optical microscopy, scanning electron microscopy, electron backscatter diffraction, transmission electron microscopy and slow strain rate test. The results indicate that the addition of Sc results in the formation of the quaternary coherent Al_3(Sc, Zr, Ti) dispersoids during homogenization treatment, which will inhibit the dynamic recrystallization behavior. The number density of Al_3(Sc, Zr, Ti) particles increases with the increase of Sc content, and thus the recrystallization fraction of hot-extruded alloy is reduced and the peak strength in two-stage artificial aging sample is enhanced. At the same time, the wide of precipitation free zone is reduced, and the content of Zn and Mg in grain boundary particles and precipitation free zone is increased with the increase of Sc content. In peak-aged state, the 0.06 wt% Sc added alloy shows the better stress corrosion cracking resistance than the Sc-free alloy because of the reduction of recrystallization fraction and the interrupted distribution of grain boundary precipitates along grain boundary. However, the further addition of Sc to 0.11 wt% will result in the deterioration of stress corrosion cracking resistance due to the increase of electrochemical activity of grain boundary particles and precipitation free zone as well as hydrogen embrittlement. | Zhaoming Li Haichang Jiang Yunli Wang Duo Zhang Desheng Yan Lijian Rong | 2018 | Journal of Materials Science & Technology2018，34，7： | 14 |
| 2 | Generation of ready to use (RTU) products over China based on Landsat series data显示文摘Earth observation community has entered into the era of big data.Family of Landsat sensors have collected massive medium resolution satellite images,which are valuable for long-term land surface monitoring.In order to significantly reduce the magnitude of data processing for remote sensing data users,Landsat-based Ready to Use(RTU)products have been produced.Main RTU products,including orthorectified products,land surface reflectance,land surface temperature,large-area mosaic image,and standard image map products,are described.The resulting Landsat RTU products are hosted on the RSGS earth observation data sharing web site for free download(http://ids.ceode.ac.cn/rtu/).These new products will provide consistent,standardized,multi-decadal image data for robust land cover change detection and monitoring across the Earth sciences.In the coming years,CASEarth DataBank system will be constructed,which is an intelligent data service platform for providing not only the RTU products from multi-source satellite data,but also big earth data analysis methods. | Guojin He Zhaoming Zhang Weili Jiao Tengfei Long Yan Peng Guizhou Wang Ranyu Yin Wei Wang Xiaomei Zhang Huichan Liu Bo Cheng Bo Xiang | 2018 | Big Earth Data2018，2，1： | 8 |
| 3 | A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle显示文摘Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles.However,ordinary antimicrobial treatments usually failed to combat multiple waves of infections during arthroplasty and prosthesis revisions etc.As these incidents could easily introduce new microbial pathogens in/onto the implants.Herein,we demonstrate that an antimicrobial trilogy strategy incorporating a sophisticated multilayered coating system leveraging multiple ion exchange mechanisms and fine nanotopography tuning,could effectively eradicate bacterial infection at various stages of implantation.Early stage bacteriostatic effect was realized via nano-topological structure of top mineral coating.Antibacterial effect at intermediate stage was mediated by sustained release of zinc ions from doped CaP coating.Strong antibacterial potency was validated at 4 weeks post implantation via an implanted model in vivo.Finally,the underlying zinc titanate fiber network enabled a long-term contact and release effect of residual zinc,which maintained a strong antibacterial ability against both Staphylococcus aureus and Escherichia coli even after the removal of top layer coating.Moreover,sustained release of Sr2+and Zn2+during CaP coating degradation substantially promoted implant osseointegration even under an infectious environment by showing more peri-implant new bone formation and substantially improved bone-implant bonding strength. | Yikai Wang Wangsiyuan Teng Zengjie Zhang Xingzhi Zhou Yuxiao Ye Peng Lin An Liu Yan Wu Binghao Li Chongda Zhang Xianyan Yang Weixu Li Xiaohua Yu Zhongru Gou Zhaoming Ye | 2021 | Bioactive Materials2021，6，7： | 3 |
| 4 | Microstructure evolution,texture and mechanical properties of a Mg-Gd-Y-Zn-Zr alloy fabricated by cyclic expansion extrusion with an asymmetrical extrusion cavity:The influence of passes and processing route显示文摘In the present work,two processing routes(A and B)with 3 CEE-AEC passes are performed on Mg-13 Gd-4 Y-2 Zn-0.4 Zr alloys,and the resultant microstructure evolution,texture analysis and mechanical properties are investigated systematically.The core difference between the two processing routes is the orientation between the expansion and extrusion steps,i.e.,they are parallel to each other for on route A and perpendicular to each other for route B.The results show that a remarkable grain refinement is achieved via both processing routes due to dynamic recrystallization(DRX).Fine equiaxed grains are observed in the samples processed with route B with a final size of 3.6±0.4μm compared to the grain size of 4.5±0.5μm with route A.With an increasing number of CEE-AEC passes,the overall texture intensity decreases,and the basal texture gradually changes to the mixed texture components.The shear deformation introduced by the asymmetrical extrusion cavity promotes a broad angular distribution of the basal planes on routes A and B,leading to an obvious increase in the Schmid factor for the activation of the basal a slip system.The tensile test at ambient temperature reveals that the comprehensive mechanical properties are improved,and the conventional mechanical anisotropy of as-received alloys is alleviated by successive CEE-AEC processing,which is mainly derived from the competitive balance relation between the grain refinement and texture modification. | Zhaoming Yan Xubin Li Jie Zheng Zhimin Zhang Qiang Wang Kaihua Xu Hongzhi Fan Guanshi Zhang Jiaxuan Zhu Yong Xue | 2021 | Journal of Magnesium and Alloys2021，9，3： | 2 |
| 5 | Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway显示文摘Ginger(Zingiber officinale),the type species of Zingiberaceae,is one of the most widespread medicinal plants and spices.Here,we report a high-quality,chromosome-scale reference genome of ginger‘Zhugen’,a traditionally cultivated ginger in Southwest China used as a fresh vegetable,assembled from PacBio long reads,Illumina short reads,and high-throughput chromosome conformation capture(Hi-C)reads.The ginger genome was phased into two haplotypes,haplotype 1(1.53 Gb with a contig N50 of 4.68 M)and haplotype 0(1.51 Gb with a contig N50 of 5.28 M).Homologous ginger chromosomes maintained excellent gene pair collinearity.In 17,226 pairs of allelic genes,11.9%exhibited differential expression between alleles.Based on the results of ginger genome sequencing,transcriptome analysis,and metabolomic analysis,we proposed a backbone biosynthetic pathway of gingerol analogs,which consists of 12 enzymatic gene families,PAL,C4H,4CL,CST,C3’H,C3OMT,CCOMT,CSE,PKS,AOR,DHN,and DHT.These analyses also identified the likely transcription factor networks that regulate the synthesis of gingerol analogs.Overall,this study serves as an excellent resource for further research on ginger biology and breeding,lays a foundation for a better understanding of ginger evolution,and presents an intact biosynthetic pathway for species-specific gingerol biosynthesis. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 2 |
| 6 | Production of transgenic pigs over-expressing theantiviral gene Mx1显示文摘The myxovirus resistance gene (Mx1) has a broad spectrum of antiviral activities. It is therefore an interestingcandidate gene to improve disease resistance in farm animals. In this study, we report the use of somatic cellnuclear transfer (SCNT) to produce transgenic pigs over-expressing the Mx1 gene. These transgenic pigs expressapproximately 15–25 times more Mx1 mRNA than non-transgenic pigs, and the protein level of Mx1 was alsomarkedly enhanced. We challenged fibroblast cells isolated from the ear skin of transgenic and control pigs withinfluenza A virus and classical swine fever virus (CFSV). Indirect immunofluorescence assay (IFA) revealed a profounddecrease of influenza A proliferation in Mx1 transgenic cells. Growth kinetics showed an approximately 10-foldreduction of viral copies in the transgenic cells compared to non-transgenic controls. Additionally, we found thatthe Mx1 transgenic cells were more resistant to CSFV infection in comparison to non-transgenic cells. These resultsdemonstrate that the Mx1 transgene can protect against viral infection in cells of transgenic pigs and indicate thatthe Mx1 transgene can be harnessed to develop disease-resistant pigs. | Quanmei Yan Huaqiang Yang Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Nana Fan Hongsheng Ouyang Weiwang Gu Liangxue Lai | 2014 | Cell Regeneration2014，3，1： | 2 |
| 7 | SARS-CoV-2 impairs the disassembly of stress granules and promotes ALS-associated amyloid aggregation显示文摘The nucleocapsid(N)protein of SARS-CoV-2 has been reported to have a high ability of liquid-liquid phase separation,which enables its incorporation into stress granules(SGs)of host cells.However,whether SG invasion by N protein occurs in the scenario of SARS-CoV-2 infection is unknow,neither do we know its con-sequence.Here,we used SARS-CoV-2 to infect mam-malian cells and observed the incorporation of N protein into SGs,which resulted in markedly impaired self-dis-assembly but stimulated cell cellular clearance of SGs.NMR experiments further showed that N protein binds to the SG-related amyloid proteins via non-specific tran-sient interactions,which not only expedites the phase transition of these proteins to aberrant amyloid aggre-gation in vitro,but also promotes the aggregation of FUS with ALS-associated P525L mutation in cells.In addition,we found that ACE2 is not necessary for the infection of SARS-CoV-2 to mammalian cells.Our work indicates that SARS-CoV-2 infection can impair the dis-assembly of host SGs and promote the aggregation of SG-related amyloid proteins,which may lead to an increased risk of neurodegeneration. | Yichen Li Shuaiyao Lu Jinge Gu Wencheng Xia Shengnan Zhang Shenqing Zhang Yan Wang Chong Zhang Yunpeng Sun Jian Lei Cong Liu Zhaoming Su Juntao Yang Xiaozhong Peng Dan Li | 2022 | Protein & Cell2022，13，8： | 1 |
| 8 | Fotemustine-based therapy in combination with rituximab as a first-line induction chemotherapy followed by WBRT for newly diagnosed primary central nervous system lymphoma: a prospective phase II trial显示文摘Objective:This study aimed to evaluate the safety,efficacy,and feasibility of the rituximab,fotemustine,pemetrexed,and dexamethasone(R-FPD)regimen followed by whole-brain radiotherapy(WBRT)for patients with primary central nervous system lymphoma(PCNSL).Methods:A prospective,single-center phase II clinical trial was conducted.Patients with PCNSL newly diagnosed at the First Affiliated Hospital of Zhengzhou University between July 2018 and July 2020 were studied.The R-FPD regimen consisted of rituximab(375 mg/m2 i.v.on D0),fotemustine(100 mg/m2 i.v.on D1),pemetrexed(600 mg/m2 i.v.on D1),and dexamethasone(40 mg i.v.on D1-5).Patients 60 years or younger who showed a complete response(CR)were treated with 23.4 Gy of WBRT after the end of chemotherapy;those older than 60 years with CR were treated with a wait-and-see approach;and those who did not show CR after the 4th cycle of chemotherapy were given salvage WBRT 30 Gy+local tumor field irradiation up to 45 Gy,regardless of age.Results:A total of 30 patients were included.After 2 cycles,the objective response rate(ORR)was 96.5%(28/29,1 CR,27 PR,0 SD,and 1 PD).After 4 cycles,the ORR was 73.1%(19/26,11 CR,8 PR,4 SD,and 3 PD).After WBRT,the ORR was 90.9%(10/11,7 CR,3 PR,and 1 SD).The grade III and IV toxicity responses were mainly leukopenia(20.0%),thrombocytopenia(23.3%),and anemia(10.0%).Conclusions:Fotemustine-based therapy in combination with rituximab chemotherapy followed by WBRT can improve outcomes,providing ORR benefits and favorable tolerability in patients newly diagnosed with PCNSL. | Jingjing Wu Fenghua Gao Wenhua Wang Xudong Zhang Meng Dong Lei Zhang Xin Li Ling Li Zhenchang Sun Xinhua Wang Xiaorui Fu Linan Zhu Mengjie Ding Songtao Niu Zhaoming Li Yu Chang Feifei Nan Jiaqian Yan Hui Yu Xiaolong Wu Zhiyuan Zhou Jieming Zhang Mingzhi Zhang | 2022 | Cancer Biology & Medicine2022，19，7： | 1 |
| 9 | Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition显示文摘Sphingosine-1-phosphate(S1P)is an important bioactive lipid molecule in cell membrane metabolism and binds to G proteincoupled S1P receptors(S1PRs)to regulate embryonic development,physiological homeostasis,and pathogenic processes in various organs.S1PRs are lipid-sensing receptors and are therapeutic targets for drug development,including potential treatment of COVID-19.Herein,we present five cryo-electron microscopy structures of S1PRs bound to diverse drug agonists and the heterotrimeric Gi protein.Our structural and functional assays demonstrate the different binding modes of chemically distinct agonists of S1PRs,reveal the mechanical switch that activates these receptors,and provide a framework for understanding ligand selectivity and G protein coupling. | Yuan Yuan Guowen Jia Chao Wu Wei Wang Lin Cheng Qian Li Ziyan Li Kaidong Luo Shengyong Yang Wei Yan Zhaoming Su Zhenhua Shao | 2021 | Cell Research2021，31，12： | 1 |
| 10 | Correction:Haplotype-resolved genome of diploid ginger (Zingiber officinale)and its unique gingerol biosynthetic pathway显示文摘After online publication of the article 1,the authors noticed the affiliation“College of Landscape Architecture and Life Science/Institute of Special Plants,Chongqing University of Arts and Sciences,Yongchuan,Chongqing,China”for author Yiqing Liu was missing. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 1 |
| 11 | Generation of gene-target dogs using CRISPR/Cas9 system显示文摘Dear Editor,Dogs(Canis familiaris)serve as human companions and are raised to herd livestock,aid hunters,guard homes,perform police and rescue work,and guide the blind.Dogs exhibit close similarities to humans in terms of metabolic,physiological,and anatomical characteristics,and thus are ideal genetic and clinical models to study human diseases(Tsai et al.,2007).Gene target technology is a powerful tool to create new strains of animals with favorable traits.However,thus far,gene-target dogs have not been developed due to their unique species-specific reproductive characteristics,which limits the applications of dogs especially in the field of biomedical research.Recently,clustered regularly interspaced short palindromic repeats(CRISPRs)/CRISPR-associated(Cas)9 system was applied to edit specific genes with a high efficiency(Cong et al.,2013;Mali et al.,2013).Here we attempt to explore the feasibility of producing gene knockout(KO)dogs by using this technology.Beagle dog,the most widely used breed in biomedical research,was used as our animal model.Myostatin(MSTN)was chosen as the first gene of interest. | Qingjian Zou Xiaomin Wang Yunzhong Liu Zhen Ouyang Haibin Long Shu Wei Jige Xin Bentian Zhao Sisi Lai Jun Shen Qingchun Ni Huaqiang Yang Huilin Zhong Li Li Minhua Hu Quanjun Zhang Zhidong Zhou Jiaxin He Quanmei Yan Nana Fan Yu Zhao Zhaoming Liu Lin Guo Jiao Huang Guanguan Zhang Jun Ying Liangxue Lai Xiang Gao | 2015 | Journal of Molecular Cell Biology2015，7，6： | 1 |
| 12 | Effect of heat treatment on mechanical properties and microstructure evolution of Mg-9.5Gd-4Y-2.2Zn-0.5Zr alloy显示文摘Regarding the as-cast Mg-9.5Gd-4Y-2.2Zn-0.5Zr alloy,the effect of heat treatment on its properties at room temperature(RT),as well as the mechanical properties and microstructure evolution of various peak-aging samples at different tensile temperatures were discussed in this article.The results indicated that the optimal heat treatment process of the alloy was:520℃×24 h+200℃×112 h.Under this condition,the yield strength(YS),ultimate tensile strength(UTS)and elongation(EL)at RT were:238 MPa,327 MPa and 2.5%,respectively.As the tensile temperature increases,the strength increases firstly and then decreases,but the ductility increases monotonously.The microstructures evolution of 200℃ peak-aging(200PA)and 250℃ peak-aging(250PA)samples were different with the increasing tensile tenperature.When tensile test processed at 150℃,the denseβ’phase and rod-shaped basalγ’phase will be formed in the 200PA sample.However,at 300℃,theβ’phases disappeared.Theβ’and LPSO phases in the 250PA sample coarsened gradually as the tensile temperature increased,and 14H-LPSO phases were formed during tensile at 300℃.The 200PA sample reached the highest strength when tensile at 150℃,which was attributed to the hindrance of the basal dislocation and non-basal dislocation slip by the prismaticβ’phases and the newly formed basalγ’precipitates. | Jie Zheng Zhaoming Yan Jinsheng Ji Yusha Shi Heng Zhang Zhimin Zhang Yong Xue | 2022 | Journal of Magnesium and Alloys2022，10，4： | 1 |
| 13 | Griseofulvin enantiomers and bromine-containing griseofulvin derivatives with antifungal activity produced by the mangrove endophytic fungus Nigrospora sp.QQYB1显示文摘Marine microorganisms have long been recognized as potential sources for drug discovery.Griseofulvin was one of the first antifungal natural products and has been used as an antifungal agent for decades.In this study,12 new griseofulvin derivatives[(±)-1-2,(+)-3,(±)-4,10-12,and 14-15]and two new griseofulvin natural products(9 and 16)together with six known analogues[(-)-3,5-8,and 13]were isolated from the mangrove-derived fungus Nigrospora sp.QQYB1 treated with 0.3%NaCl or 2%NaBr in rice solid medium.Their 2D structures and absolute configurations were established by extensive spectroscopic analysis(1D and 2D NMR,HRESIMS),ECD spectra,computational calculation,DP4+analysis,and X-ray single-crystal diffraction.Compounds 1-4 represent the first griseofulvin enantiomers with four absolute configurations(2S,6'S;2R,6'R;2S,6'R;2R,6'S),and compounds 9-12 represent the first successful production of brominated griseofulvin derivatives from fungi via the addition of NaBr to the culture medium.In the antifungal assays,compounds 6 and 9 demonstrated significant inhibitory activities against the fungi Colletotrichum truncatum,Microsporum gypseum,and Trichophyton mentagrophyte with inhibition zones varying between 28 and 41 mm(10μg/disc).The structure-activity relationship(SAR)was analyzed,which showed that substituents at C-6,C-7,C-6'and the positions of the carbonyl and double bond of griseofulvin derivatives significantly affected the antifungal activity. | Ge Zou Wencong Yang Tao Chen Zhaoming Liu Yan Chen Taobo Li Gulab Said Bing Sun Bo Wang Zhigang She | 2024 | Marine Life Science & Technology2024，6，1： | 0 |
| 14 | Cryo-EM structure of the nucleocapsid-like assembly of respiratory syncytial virus显示文摘Respiratory syncytial virus(RSV)is a nonsegmented,negative strand RNA virus that has caused severe lower respiratory tract infections of high mortality rates in infants and the elderly,yet no effective vaccine or antiviral therapy is available.The RSV genome encodes the nucleoprotein(N)that forms helical assembly to encapsulate and protect the RNA genome from degradation,and to serve as a template for transcription and replication.Previous crystal structure revealed a decameric ring architecture of N in complex with the cellular RNA(N-RNA)of 70 nucleotides(70-nt),whereas cryo-ET reconstruction revealed a low-resolution left-handed filament,in which the crystal monomer structure was docked with the helical symmetry applied to simulate a nucleocapsid-like assembly of RSV.However,the molecular details of RSV nucleocapsid assembly remain unknown,which continue to limit our complete understanding of the critical interactions involved in the nucleocapsid and antiviral development that may target this essential process during the viral life cycle.Here we resolve the near-atomic cryo-EM structure of RSV N-RNA that represents roughly one turn of the helical assembly that unveils critical interaction interfaces of RSV nucleocapsid and may facilitate development of RSV antiviral therapy. | Yan Wang Chong Zhang Yongbo Luo Xiaobin Ling Bingnan Luo Guowen Jia Dan Su Haohao Dong Zhaoming Su | 2023 | Signal Transduction and Targeted Therapy2023，8，9： | 0 |
| 15 | Phototriggered Formation of a Supramolecular Polymer Network Based on Orthogonal H-Bonding and Host-Guest Recognition显示文摘Supramolecular polymer networks(SPNs)have gained increasing research attention due to their reversible and tunable nature in the preparation of adaptive materials.The use of hierarchical self-assembly techniques is an emerging strategy for the fabrication of smart supramolecular polymer networks,but corresponding study is still rare.Herein,we have reported a novel supramolecular polymer network through complementary host-guest interactions and phototriggered quadruple H-bonding cross-linking.Specifically,we design and synthesize an H1G1-type monomer consisting of a benzo-21-crown-7(B21C7)host(H1),a dialkylammonium salt guest(G1)and a photolabile o-nitrobenzyl ether protected ureidopyrimidinone(Upy)moiety.B21C7 and ammonium moieties can first form a linear supramolecular polymer through complementary host-guest interactions.Under photoirradiation,the Upy groups on the SP side chains were released,and the obtained linear supramolecular polymer could be further transformed into SPN through a quadruple H-bonding cross-linking.Meanwhile,the in situ transformation in the solid state is also accompanied by pronounced enhancement in mechanical properties,which provides foundation for further application of materials in different scenarios. | BAI Ruixue YANG Xue ZHAO Jun ZHANG Zhaoming YAN Xuzhou | 2023 | Chemical Research in Chinese Universities2023，39，5： | 0 |
| 16 | Molecular phylogeny and divergence time estimates using the mitochondrial genome for the hadal snailfish from the Mariana trench显示文摘Snailfishes are an important component of the hadal fish fauna[1].Based on osteological and other morphological characters,Kido[2]recognized the Cyclopteridae as a sister group to the Liparidae and the superfamily Cottoidea as a sister group to the two families.The close relationship between Liparidae and Cyclopteridae is | Yanjun Shen Wei Dai Zhaoming Gao Guoyong Yan Xiaoni Gan Shunping He | 2017 | Science Bulletin2017，62，16： | 0 |
| 17 | Generation of pigs with humanized type Ⅱ collagen by precise human COL2A1 gene knock-in显示文摘Osteoarthritis(OA)is the most common chronic disease,characterized by progressive cartilage breakdown,subchondral bone sclerosis,and aberrant bone outgrowth(Yucesoy et al.,2015;Hussain et al.,2016).OA is one of the leading causes of cartilage damage.Patients with severe cartilage damage require transplantation of articular cartilage to improve their quality of life.Type Ⅱ collagen is a major component of articular cartilage and intervertebral discs and plays an important role in the structure and strength of connective tissues that support muscles and joints(Byers,1994). | Ting Lan Yuling Zheng Yangyang Suo Yuhui Wei Hui Shi Quanmei Yan Zhenpeng Zhuang Huangyao Chen Quanjun Zhang Nana Fan Yu Zhao Zhen Ouyang Chengdan Lai Zhaoming Liu Jizeng Zhou Chengcheng Tang Nam-Hyung Kim Qingjian Zou Xiaomin Wang | 2023 | Journal of Genetics and Genomics2023，50，3： | 0 |
| 18 | Predicting recurrence in osteosarcoma via a quantitative histological image classifier derived from tumour nuclear morphological features显示文摘Recurrence is the key factor affecting the prognosis of osteosarcoma.Currently,there is a lack of clinically useful tools to predict osteosarcoma recurrence.The application of pathological images for artificial intelligence‐assisted accurate prediction of tumour out-comes is increasing.Thus,the present study constructed a quantitative histological image classifier with tumour nuclear features to predict osteosarcoma outcomes using haema-toxylin and eosin(H&E)‐stained whole‐slide images(WSIs)from 150 osteosarcoma patients.We first segmented eight distinct tissues in osteosarcoma H&E‐stained WSIs,with an average accuracy of 90.63%on the testing set.The tumour areas were auto-matically and accurately acquired,facilitating the tumour cell nuclear feature extraction process.Based on six selected tumour nuclear features,we developed an osteosarcoma histological image classifier(OSHIC)to predict the recurrence and survival of osteo-sarcoma following standard treatment.The quantitative OSHIC derived from tumour nuclear features independently predicted the recurrence and survival of osteosarcoma patients,thereby contributing to precision oncology.Moreover,we developed a fully automated workflow to extract quantitative image features,evaluate the diagnostic values of feature sets and build classifiers to predict osteosarcoma outcomes.Thus,the present study provides a novel tool for predicting osteosarcoma outcomes,which has a broad application prospect in clinical practice. | Zhan Wang Haoda Lu Yan Wu Shihong Ren Diarra mohamed Diaty Yanbiao Fu Yi Zou Lingling Zhang Zenan Wang Fangqian Wang Shu Li Xinmi Huo Weimiao Yu Jun Xu Zhaoming Ye | 2023 | CAAI Transactions on Intelligence Technology2023，8，3： | 0 |
| 19 | Forest status assessment in China with SDG indicators based on high-resolution satellite data显示文摘To assess the status and change trend of forest in China,an indicator framework was developed using SDG sub-indicators.In this paper,we propose an improved methodology and a set of workflows for calculating SDG indicators.The main modification include the use of moderate and high spatial resolution satellite data,as well as state-of-the-art machine learning techniques for forest cover classification and estimation of forest above-ground biomass(AGB).This research employs GF-1 and GF-2 data with enhanced texture information to map forest cover,while time series Landsat data is used to estimate forest AGB across the whole territory of China.The study calculate two SDG sub-indicators:SDG_(15.1.1) for forest area and SDG_(15.2.1) for sustainable forest management.The evaluation results showed that the total forest area in China was approximately 219 million hectares at the end of 2021,accounting for about 23.51%of the land area.The average annual forest AGB from 2015 to 2021 was estimated to be 105.01Mg/ha,and the overall trend of forest AGB change in China was positive,albeit with some spatial differences. | Xiaomei Zhang Guojin He Shijie Yan Tengfei Long Xueli Peng Zhaoming Zhang Guizhou Wang | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
| 20 | Weldable and closed-loop recyclable monolithic dynamic covalent polymer aerogels显示文摘Owing to their low density,high porosity and unique micro-nanostructures,aerogels are attractive for application in various fields;however,they suffer from shrinkage and/or cracking during preparation,mechanical brittleness,low production efficiency and non-degradation.Herein,we introduce the concept of dynamic covalent polymer chemistry to produce a new class of aerogels—referred to as DCPAs.The resulting lightweight DCPAs have the potential to be prepared on a large scale and feature high porosity(90.7%–91.3%),large degrees of compression(80%strain)and bending(diametral deflection of 30 mm)without any cracks,as well as considerable tensile properties(an elongation with a break at 32.7%).In addition,the DCPAs showcase the emergent characteristics of weldability,repairability,degradability and closed-loop recyclability that are highly desirable for providing versatile material platforms,though hardly achieved by traditional aerogels.Taking advantage of their robust porous structures,we demonstrate the potential of DCPAs for applications in thermal insulation and emulsion separation.These findings reveal that the dynamic covalent bond strategy would be generalized for the production of a new generation of aerogels with customized features for functioning in the field of intelligent and sustainable materials. | Xinhai Zhang Jun Zhao Kai Liu Guangfeng Li Dong Zhao Zhaoming Zhang Junjun Wan Xue Yang Ruixue Bai Yongming Wang Wei Zhang Xuzhou Yan | 2022 | National Science Review2022，9，9： | 0 |
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