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| 1 | Bathymetric Prediction from Multi-source Satellite Altimetry Gravity Data显示文摘According to the 'theoretical admittance ' and the 'observation admittance' of the actual data,the theoretical value of effective elastic thickness in the study area was 10 km.Combining the gravity anomalies and vertical gravity gradient anomalies,the admittance function is used to construct the 1′×1′ bathymetry model over the Philippine Sea by using the adaptive weighting technique.It is found that the accuracy of the bathymetry model constructed is the highest when the ratio of inversion result of vertical gravity gradient anomalies and inversion result of gravity anomalies is 2∶3.At the same time,using multi-source gravity data to predict bathymetry could synthesize the superiority of gravity anomalies and vertical gravity gradient anomalies on the different seafloor topography,and the accuracy is better than bathymetry model that only used gravity anomalies or vertical gravity gradient anomalies.Taking the ship test data as the checking condition,the accuracy of predicting model is slightly lower than that of V18.1 model and improved by 27.17% and 39.02% respectively compared with the ETOPO1 model and the DTU10 model.Check points which the absolute value of the relative error of the predicting model is in the range of 5% accounted for 94.25% of the total. | Diao FAN Shanshan LI Shuyu MENG Chi ZHANG Jinkai FENG Yan HUANG Jiawei DU Zhibin XING | 2019 | Journal of Geodesy and Geoinformation Science2019，2，1： | 6 |
| 2 | Composite Sinusoidal Nanograting With Long-Range SERS Effect for Label-Free TNT Detection显示文摘一合成一个维(1D ) 瞄准没有标签的表面的 Ag 正弦曲线 nanograting 提高了散布的拉曼(重量的单位) 有柔韧、可再现的改进的 TNT 的察觉被讨论。周期的正弦曲线 SiO 2 栅栏由 Ag 蒸发跟随了的 1D 基于表面电浆子电磁声子(SPP ) 为可再现、有效的重量的单位底层的创造被建议。1D 正弦曲线 nanograting 和它的远程的重量的单位效果的最佳的结构被使用有限差别时间领域(FDTD ) 分析。模拟重量的单位改进因素(EF ) 能是同样可能的 5 个数量级。这重量的单位底层被干扰影印石版术技术准备,它的重量的单位表演被 Rh6G 察觉实验测试,并且实际测试 EF 是大约 10 4 。TNT 的没有标签的重量的单位察觉能力在实验被表明。 | Cheng XIAO Zhibin CHEN Mengze QIN Dongxiao ZHANG Lei FAN | 2018 | Photonic Sensors2018，8，3： | 4 |
| 3 | The pain-related behavior changes correlate with the bone damage in a rat model of rheumatoid arthritis显示文摘Objective: In view of the extensive bone damage in rheumatoid arthritis, we used a commonly utilized animal model to detect behavioral changes in pain-related and the bone damage during the early disease, and to explore the correlation between bone damage and pain-related behavioral changes. Methods: Arthritis were induced in Sprague-Dawley (SD) male rats by injecting complete Freund's adjuvant (CFA) into the tails. Pain-related behavior changes were studied using the Hargreaves, VonFrey, and acetone tests on the 0, 7, 14, day and 28 day after CFA injection. The rats were sacrificed according the same schedule. The bone damage of the right proximal tibia was studied by microCT scan and bone histological slices. Results: Animals developed soft tissue inflammation and polyarthritis on 7 days after CFA injection, and arthritic score proved obvious arthritis were established within the study period. Mechanical hyperalgesia and cold allodynia were present in the affected hind paw from the 7 day through the 28 day, but the heat hyperalgesia and the mechanical allodynia lasted a short time after CFA injection. Trabecular bone number (Tb.N), Tissue Mineral Content (TMC) and Bone Volume to Tissue Volume (BV/TV) in the proximal tibia by microCT scan were also reduced after induction, especial 14 days after CFA injection. The bone histological slices showed the trabecular bone and proteoglycan diminished, the bone damage severity scores became more severely on the 7 day after CFA injection. Using analysis of covariance, these changes had statistical significance compared with baseline. By linear regression analysis demonstrated mechanical hyperalgesia and cold allodynia correlated well with arthritic score, bone damage parameters and bone damage severity scores. Conclusion: Adjuvant-induced arthritis (AA) were observed after CFA injection and lasted within the later experimental period. Pain-related behavioral changes were observed in the early time of AA. Bone damage was also occurred with arthritis development. Pain-related behavioral change correlated well with arthritic score and bone damage parameters. | ZHENG Shicheng WANG Kunzheng FAN Lihong SHI Zhibin CHEN Junchang BAO Hongxiang | 2013 | Journal of Medical Colleges of PLA(China)2013，28，3： | 3 |
| 4 | Electron back-scattering diffraction preliminary analysis of heterogeneous nuclei in magnesium alloy during solidification process under GPa high pressure显示文摘The effective heterogeneous nuclei in Mg-7.92 Zn-1.70 Y alloy during solidification process under high pressure was investigated by EBSD. It is found that the orientation relationship between Mg matrix and MgY phase, [111]_(MgY)//[1210]_(α-Mg) and(101)_(MgY)//(0001)_(α-Mg), exists between Mg matrix and MgY phase.The MgY phase is the potential heterogeneous nuclei substrate for a-Mg solidified under high pressure. It is calculated by Bramfitt mode that the mismatch between Mg matrix and MgY phase is greater than 12% under atmospheric pressure. When solidified under high pressure of 4 GPa, the solidification pressure can increase the number of the α-Mg nucleus by reducing the size of the nucleus, decreasing interfacial energy of MgY/a-Mg, and changing the wettability between MgY phase and α-Mg from non-wetting under atmospheric pressure to wetting under high pressure. The MgY phase becomes a powerful heterogeneous nuclei for α-Mg crystal. Increasing the number of valid heterogeneous nuclei substrate increases nucleus number and refines the grain of the alloy. | Zhibin Fan Xiaoping Lin Rui Xu Yun Dong Bin Wen Lin Wang Shengshi Zhao | 2018 | Journal of Rare Earths2018，36，2： | 3 |
| 5 | Design,Manufacture and Maintenance of Pressure Equipment Based on Accidents Survey显示文摘Most of the important units of pressure equipment have been manufactured successfully in China related to the national key construction projects,such as 10 million tons/year oil refinery,million tons/year ethylene,large coal chemical,etc.However,some of them failed to operate shortly after their putting into service.Some suffered severe damage even during the previous period of manufacture and installation.In this paper,cases of accident survey and failure analysis are given for some typical pressure vessels.It is found that many accidents are related to insufficient consideration of the design and manufacture of the equipment.These accidents occur fundamentally because of the Chinese design standards & codes for pressure equipment without risk or life concepts and the support from a database for potential risk existing in their dynamic service.Most designers and manufacturers are unable to make correct design,materials selection and manufacturing process all due to a lack of engineering experience.In order to avoid the repetition of the accidents and improve the safety,reliability and economy of pressure equipment,a platform is suggested for design,manufacture and maintenance of pressure equipment in China based on accidents survey.In other words,some effective precautionary measures are taken at the design and manufacture stage,and the design methodology has to be based on service life requirement and desirable risk level.At the service stage some reasonable inspection/monitoring approaches should be utilized to control risks and ensure the equipment operating safely until its desired lifespan.Finally,the basic scheme and some key technologies are briefly given for the platform construction.The concept of risk and life based design,manufacture and maintenance proposed herein has important significance for improving and perfecting the codes and standards for design,manufacture and maintenance of Chinese pressure-bearing equipment,enhancing the life and reliability of Chinese pressure-bearing equipment and promoting the development of in-service maintenance technology that combines safety and economy. | CHEN Xuedong AI Zhibin FAN Zhichao WANG Bing DOU Wanbo YANG Tiecheng GUAN Weihe | 2011 | Chinese Journal of Mechanical Engineering2011，24，2： | 3 |
| 6 | Room temperature compressive properties and strengthening mechanism of Mg96.17Zn3.15Y0.50Zr0.18 alloy solidified under high pressure显示文摘The microstructures of Mg96.17Zn3.15Y0.50Zr0.18 alloys solidified under 2-6 GPa high pressure were investigated by employing SEM(EDS) and TEM.The strengthening mechanism of experimental alloy solidified under high pressure is also discussed by analyzing the compressive properties and compression fracture morphology.The results show that the microstructure of experimental alloy becomes significantly fine-grained with increasing GPa level high pressure during solidification process,and the secondary dendrite arm spacing reduces from 40 μm at atmospheric pressure to 10 μm at 6 GPa pressure.The morphology of the second phases changes from the net structure by the lamellar-type eutectic structure at atmospheric pressure to discontinuous thin rods or particles at 6 GPa pressure.Besides,the solid solubility of Zn in the Mg matrix is improved with the increase of the solidification pressure.Compared with atmospheric-pressure solidification,high-pressure solidification can improve the strength of the experimental alloy.The compressive stre ngth is improved from 263 to 437 MPa at 6 GPa.The fracture mechanism of the experimental alloy changes from cleavage fracture at atmospheric pressure to quasi-cleavage fracture at high pressure.The main mechanism of the strength improvement of the experimental alloy includes the grain refinement strengthening caused by the refinement of the solidification microstructure,the second phase strengthening caused by the improvement of the morphology and distribution of the second phases,and solid solution strengthening caused by the increase of the solid solubility of Zn in the Mg matrix. | Xiaoping Lin Zhibin Fan Chang Xu Kunyu Guo Chang Xu Shiqi Guo | 2020 | Journal of Rare Earths2020，38，6： | 2 |
| 7 | Potentially functional genetic variants in microRNA processing genes and risk of HBV‐related hepatocellular carcinoma显示文摘 | Li Liu Jiaze An Jibin Liu Juan Wen Xiangjun Zhai Yao Liu Shandong Pan Jie Jiang Yang Wen Zheng Liu Yixin Zhang Jianguo Chen Jinliang Xing Guozhong Ji Hongbing Shen Zhibin Hu Zhining Fan | 2013 | Mol Carcinog2013，，1： | 1 |
| 8 | Dynamic mechan- ical and rheological properties of metallocene-catalyzed long- chain-branched ethylene/propylene copolymers显示文摘 | Wang Wenjun Ye Zhibin Fan Hong | 2004 | Polymer2004，45，16： | 1 |
| 9 | Intelligent Antenna Attitude Parameters Measurement Based on Deep Learning SSD Model显示文摘Due to the consideration of safety,non-contact measurement methods are be-coming more acceptable.However,massive measurement will bring high labor-cost and low working efficiency.To address these limitations,this paper introduces a deep learning model for the antenna attitude parameter measurement,which can be divided into an an-tenna location phase and a calculation phase of the attitude parameter.In the first phase,a single shot multibox detector(SSD)is applied to automatically recognize and discover the antenna from pictures taken by drones.In the second phase,the located antennas’fea-ture lines are extracted and their attitude parameters are then calculated mathematically.Experiments show that the proposed algorithms outperform existing related works in effi-ciency and accuracy,and therefore can be effectively used in engineering applications. | FAN Guotian WANG Zhibin | 2022 | ZTE Communications2022，20，S01： | 1 |
| 10 | A biomass based photonic crystal made of 'konjac tofu'显示文摘Konjac tofu is a traditional Chinese food whose main ingredient is the water-soluble polysaccharide from konjac tubers-konjac glucomannan(KGM).Herein we report an interpenetrating double network polymeric film by crosslinking KGM and polyvinyl alcohol(PVA) with glutaraldehyde under acidic conditions.PVA was introduced into the hydrogel system as a hard skeleton,which not only maintained the biocompatibility of KGM,but also gave the hydrogel superior mechanical properties and solvent resistance.Implanting a colloidal array inside the above film,we obtained a new type of biomass based photonic crystal that is sensitive to a variety of physical and chemical stimulus,especially for methanol.This photonic crystal responds to metha nol and methanol vapo r,and has the ability to detect methanol in gasoline,which has a good application prospect. | Wenxin Zhang Min Xue Kenneth J.Shea Lili Qiu Zhibin Xu Jing Fan Dan Yan Zihui Meng | 2021 | Chinese Chemical Letters2021，32，1： | 1 |
| 11 | Distance-controllable and direction-steerable opto-conveyor for targeting delivery显示文摘Opto-conveyors have attracted widespread interest in various fields because of their non-invasive and non-contact delivery of micro/nanoparticles.However,the flexible control of the delivery distance and the dynamic steering of the delivery direction,although very desirable in all-optical manipulation,have not yet been achieved by optoconveyors.Here,using a simple and cost-effective scheme of an elliptically focused laser beam obliquely irradiated on a substrate,a direction-steerable and distance-controllable opto-conveyor for the targeting delivery of microparticles is implemented.Theoretically,in the proposed scheme of the opto-conveyor,the transverse and longitudinal resultant forces of the optical gradient force and the optical scattering force result in the transverse confinement and the longitudinal transportation of microparticles,respectively.In this study,it is experimentally shown that the proposed opto-conveyor is capable of realizing the targeting delivery for microparticles.Additionally,the delivery distance of microparticles can be flexibly and precisely controlled by simply adjusting the irradiation time.By simply rotating the cylindrical lens,the proposed opto-conveyor is capable of steering the delivery direction flexibly within a large range of azimuthal angles,from-75°to 75°.This study also successfully demonstrated the real-time dynamic steering of the delivery direction from-45°to 45°with the dynamical rotation of the cylindrical lens.Owing to its simplicity,flexibility,and controllability,the proposed method is capable of creating new opportunities in bioassays as well as in drug delivery. | Zhen Che Wenguo Zhu Yaoming Huang Yu Zhang Linqing Zhuo Pengpeng Fan Zhibin Li Huadan Zheng Wenjin Long Wentao Qiu Yunhan Luo Jun Zhang Jinghua Ge Jianhui Yu Zhe Chen | 2020 | Photonics Research2020，8，7： | 1 |
| 12 | Identification of A-to-I RNA editing profiles and their clinical relevance in lung adenocarcinoma显示文摘Adenosine-to-inosine(A-to-I)RNA editing is a widespread posttranscriptional modification that has been shown to play an important role in tumorigenesis.Here,we evaluated a total of 19,316 RNA editing sites in the tissues of 80 lung adenocarcinoma(LUAD)patients from our Nanjing Lung Cancer Cohort(NJLCC)and 486 LUAD patients from the TCGA database.The global RNA editing level was significantly increased in tumor tissues and was highly heterogeneous across patients.The high RNA editing level in tumors was attributed to both RNA(ADAR1 expression)and DNA alterations(mutation load).Consensus clustering on RNA editing sites revealed a new molecular subtype(EC3)that was associated with the poorest prognosis of LUAD patients.Importantly,the new classification was independent of classic molecular subtypes based on gene expression or DNA methylation.We further proposed a simplified model including eight RNA editing sites to accurately distinguish the EC3 subtype in our patients.The model was further validated in the TCGA dataset and had an area under the curve(AUC)of the receiver operating characteristic curve of 0.93(95%CI:0.91-0.95).In addition,we found that LUAD cell lines with the EC3 subtype were sensitive to four chemotherapy drugs.These findings highlighted the importance of RNA editing events in the tumorigenesis of LUAD and provided insight into the application of RNA editing in the molecular subtyping and clinical treatment of cancer. | Cheng Wang Mingtao Huang Congcong Chen Yuancheng Li Na Qin Zijian Ma Jingyi Fan Linnan Gong Hui Zeng Liu Yang Xianfeng Xu Jun Zhou Juncheng Dai Guangfu Jin Zhibin Hu Hongxia Ma Fengwei Tan Hongbing Shen | 2022 | Science China(Life Sciences)2022，65，1： | 1 |
| 13 | Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury显示文摘 | Lihong Fan Kunzheng Wang Zhibin Shi Jun Die | 2011 | Journal of Vascular Surgery2011，54，1： | 1 |
| 14 | Tetramethylpyrazine protects spinal cord and reduces inflammation in a rat model of spinal cord ischemia-reperfusion injury显示文摘 | Lihong Fan Kunzheng Wang Zhibin Shi Jun Die Chunsheng Wang Xiaoqian Dang | 2011 | Journal of Vascular Surgery2011，，1： | 1 |
| 15 | Short-term Outcomes of Induction Therapy With Tacrolimus Versus Cyclophosphamide for Active Lupus Nephritis: A Multicenter Randomized Clinical Trial显示文摘 | Wei Chen Xueqing Tang Qinghua Liu Weiying Chen Ping Fu Fang Liu Yunhua Liao Zhenhua Yang Jinli Zhang Jian Chen Tanqi Lou Junzhou Fu Yaozhong Kong Zhengrong Liu An Fan Shaoqi Rao Zhibin Li Xueqing Yu | 2011 | American Journal of Kidney Diseases2011，，2： | 1 |
| 16 | Zircon U-Pb Ages of Tonalite in Faku,Liaoning Province,China,and the Early Paleozoic Magmatic Activity in the North Margin of the North China Craton显示文摘Objective Due to the Meso-Cenozoic Songliao Basin coverage,the Early Paleozoic continental-margin accretionary belt has not been detected in the middle of the north margin of the North China Craton (Liu et al., 2017a, b). | SHI Yiu ZHANG Zhibin YANG Fan LI Dongtao SHI Shaoshan ZHAO Chunqiang YOU Hongxi | 2019 | Acta Geologica Sinica(English Edition)2019，93，2： | 1 |
| 17 | Genomic mosaicism due to homoeologous exchange generates extensive phenotypic diversity in nascent allopolyploids显示文摘Allopolyploidy is an important process in plant speciation,yet newly formed allopolyploid species typically suffer from extreme genetic bottlenecks.One escape from this impasse might be homoeologous meiotic pairing,during which homoeologous exchanges(HEs)generate phenotypically variable progeny.However,the immediate genome-wide patterns and resulting phenotypic diversity generated by HEs remain largely unknown.Here,we analyzed the genome composition of 202 phenotyped euploid segmental allopolyploid individuals from the fourth selfed generation following chromosomal doubling of reciprocal F1 hybrids of crosses between rice subspecies,using whole-genome sequencing.We describe rampant occurrence of HEs that,by overcoming incompatibility or conferring superiority of hetero-cytonuclear interactions,generate extensive and individualized genomic mosaicism across the analyzed tetraploids.We show that the resulting homoeolog copy number alteration in tetraploids affects known-function genes and their complex genetic interactions,in the process creating extraordinary phenotypic diversity at the population level following a single initial hybridization.Our results illuminate the immediate genomic landscapes possible in a tetraploid genomic environment,and underscore HE as an important mechanism that fuels rapid phenotypic diversification accompanying the initial stages of allopolyploid evolution. | Ying Wu Fan Lin Yao Zhou Jie Wang Shuai Sun Bin Wang Zhibin Zhang Guo Li Xiuyun Lin Xutong Wang Yue Sun Qianli Dong Chunming Xu Lei Gong Jonathan F.Wendel Zhiwu Zhang Bao Liu | 2021 | National Science Review2021，8，5： | 1 |
| 18 | Genetic variants in pseudogene E2F3P1 confer risk for HBV-related hepatocellular carcinoma in a Chinese population显示文摘Recent studies showed that pseudogenes can regulate the expression of their coding gene partners by competing for miRNAs. The E2F family plays a crucial role in the control of cell cycle checkpoint. E2F3P1 is a pseudogene of E2F3. Few studies focused on genetic variations on pseudogenes. In this study, we performed a case-control study to assess the association between single nucleotide polymorphisms (SNPs) in E2F3P1 and hepatocellular carcinoma (HCC) risk in 1050 hepatitis B virus (HBV)-positive HCC cases and 1050 chronic HBV carriers. Logistic regression analysis was applied to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for the associations between genotypes and HCC risk. We found that the variant CT/TT genotypes of rs1838149 were associated with a significantly decreased risk of HCC (adjusted OR=0.66, 95% CIs=0.51-0.86, P=0.002) compared to those with wildtype CC homozygote. Furthermore, the AA genotype of rs9909601 had an increased HCC risk with an adjusted OR of 1.41 (95% CIs=1.07-1.86), and the A allele of rs9909601 was significantly associated with HCC risk compared to those with the G allele (adjusted OR=1.17, 95% CIs=1.03-1.33, P=0.017). These results indicate that genetic variations in the pseudogene E2F3P1 may confer HCC risk. | Li Liu Yao Liu Jibin Liu Xiangjun Zhai Juan Wen Kaipeng Xie Hongbing Shen Zhibin Hu Zhining Fan | 2013 | The Journal of Biomedical Research2013，27，3： | 1 |
| 19 | Renin--angiotensin system inhibitor is associated with the reduced risk of all-cause mortality in COVID-19 among patients with/without hypertension显示文摘Consecutively hospitalized patients with confirmed coronavirus disease 2019(COVID-19)in Wuhan,China were retrospectively enrolled from January 2020 to March 2020 to investigate the association between the use of renin–angiotensin system inhibitor(RAS-I)and the outcome of this disease.Associations between the use of RAS-I(angiotensin-converting enzyme inhibitor(ACEI)or angiotensin receptor blocker(ARB)),ACEI,and ARB and in-hospital mortality were analyzed using multivariate Cox proportional hazards regression models in overall and subgroup of hypertension status.A total of 2771 patients with COVID-19 were included,with moderate and severe cases accounting for 45.0%and 36.5%,respectively.A total of 195(7.0%)patients died.RAS-I(hazard ratio(HR)=0.499,95%confidence interval(CI)0.325–0.767)and ARB(HR=0.410,95%CI 0.240–0.700)use was associated with a reduced risk of all-cause mortality among patients with COVID-19.For patients with hypertension,RAS-I and ARB applications were also associated with a reduced risk of mortality with HR of 0.352(95%CI 0.162–0.764)and 0.279(95%CI 0.115–0.677),respectively.RAS-I exhibited protective effects on the survival outcome of COVID-19.ARB use was associated with a reduced risk of all-cause mortality among patients with COVID-19. | Huai-yu Wang Suyuan Peng Zhanghui Ye Pengfei Li Qing Li Xuanyu Shi Rui Zeng Ying Yao Fan He Junhua Li Liu Liu Shuwang Ge Xianjun Ke Zhibin Zhou Gang Xu Ming-hui Zhao Haibo Wang Luxia Zhang Erdan Dong | 2022 | Frontiers of Medicine2022，16，1： | 0 |
| 20 | Modeling of contact temperatures and their influence on the tribological performance of PEEK and PTFE in a dual-pin-ondisk tribometer显示文摘The direct blending of polyether ether ketone(PEEK)with a solid lubricant such as polytetrafluoroethylene(PTFE)improves its tribological performance,but compromises its outstanding mechanical properties and processability.While these negative effects might be circumvented via the hybrid wear method,the influence of the contact temperature between multiple sliding components acting together is not fully understood.Herein,an analytical temperature model considering the influence of both micro-and macro-thermal behavior is extended to predict the contact temperature of a dual-pin-on-disk hybrid wear system.The interactions between several heat sources are investigated and experimentally verified.The analytical results show that the nominal temperature rise of the shared wear track is determined by the combined effect of the heat generated by both pin components,while the rise in flash temperature at the region in contact with each pin component is dependent upon its individual characteristics and working conditions.Hence,while different temperature peaks can coexist in the shared wear track,the maximum value dominates the performance of the system.For the experimentally investigated PEEK–PTFE–steel hybrid wear system,the formation of tribofilms is blocked,and the hybrid wear system fails,when the peak temperature exceeds the glass transition temperature of both pins due to an increase in applied load. | Zhibin LIN Ting QU Ke ZHANG Qingbin ZHANG Shengdao WANG Guibin WANG Bingzhao GAO Guowei FAN | 2023 | Friction2023，11，4： | 0 |
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