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| 1 | High-resolution carbon isotope record for the Paleocene-Eocene thermal maximum from the Nanyang Basin,Central China显示文摘古新始新世的热最大值(PETM ) 是全球温暖的一个短暂事件,与发生在古新 / 始新世的边界的巨大的大气的温室气体输入联系了。Biostratigraphic 和同位素 stratigraphic 研究显示 PETM 事件很好在 Nanyang 盆在 Yuhuangding 节的泥土存款被记录,华中,与碳同位素,在 19-m-thick 泥土以内的锝 ?.1 鈥 ? 的否定旅行扔。这是到目前为止在世界上发现的 PETM 的最高的分辨率记录。PETM 事件在 2-cm-thick 泥土沉积以内被触发,与未 1 3C (稳定的碳同位素比率) 从的减少 ? 3.2 鈥 ? 到 ? 5.2 鈥吗?为是的一个短暂时期建议一个巨大的甲烷水合物版本可能由一个灾难的事件引起了。在海洋、陆上的记录之间的比较为 PETM 事件显示鈥淭h ree 阶段模型鈥 ? 。开始在未 1 3C 记录有一次快速的否定旅行,由一个慢慢地减少的趋势,然后渐渐的积极恢复列在后面,相应分别地到海洋的甲烷水合物的快速的分离,由甲烷然后释放甲烷的消费的一个慢版本列在后面。 | ZHU Min DINGZhongLi WANG Xu CHEN ZuoLing JIANG HanChao DONG XinXin JI JunLiang TANG ZiHua LUO Pan | 2010 | Chinese Science Bulletin2010，55，31： | 6 |
| 2 | Agonistic AT_1 Receptor Autoantibody Increases in Serum of Patients with Refractory Hypertension and Improves Ca^(2+) Mobilization in Cultured Rat Vascular Smooth Muscle Cells显示文摘Agonistic AT1 receptor autoantibodies (AT1-AAs) have been described in the patients with malignant hypertension or preeclampia. Furthermore, AT1-AAs were highly associated with refractory hypertension. Function of vascular smooth muscle cells (VSMCs) is important in the regulation of blood pressure. We investigated and compared the ability of angiotensin II (Ang II) and AT1-AAs to stimulate the intracellular calcium mobilization and cellular proliferation of rat VSMCs. Twenty-two patients with refractory hypertension, 24 patients with non-refractory hypertension and 37 normotensives were recruited. The serum of each patient was detected for the presence of AT1-AAs by ELISA. Ang II and the AT1-AAs from the sera of patients were used to stimulate rat VSMCs in vitro. AT1-AAs were detected in 10/22, 3/24 and 3/37 of patients with refractory hypertension, non-refractory hypertension and normotensives, respectively. AT1-AAs led the increase intracellular calcium mobilization in a dose-dependent manner and cellular proliferation of VSMCs just as Ang II. Both of these effects caused by AT1-AAs were blocked with losartan or a peptide corresponding to a part of the second extracellular loop of AT1 receptor. Since AT1-AAs exhibited pharmacological activity in rat VSMCs just as Ang II, they might play a role in the elevation of peripheral vascular resistance and in vascular remodeling. And AT1-AAs were suggested to involve in resistance to antihypertensive therapy. | Feng Zhu Yanxiang Sun Yuhua Liao Yumiao Wei Ming Chen Min Wang Zihua Zhou | 2008 | Cellular & Molecular Immunology2008，5，3： | 4 |
| 3 | A Clinicopathological Study on the Expression of Cadherin-17 and Caudal-related Homeobox Transcription Factor (CDX2) in Human Gastric Carcinoma显示文摘 | Jie Ge Zhikang Chen Shaobin Wu Weijie Yuan Bin Hu Zihua Chen | 2008 | Clinical Oncology2008，，4： | 2 |
| 4 | Overexpression of EphA2 correlates with epithelial–mesenchymal transition-related proteins in gastric cancer and their prognostic importance for postoperative patients显示文摘 | Futao Hou Weijie Yuan Jin Huang Liyuan Qian Zhikang Chen Jie Ge Shaobin Wu Jinxiang Chen Jixu Wang Zihua Chen | 2012 | Medical Oncology2012，，4： | 2 |
| 5 | The relationship between p27<sup>kip1</sup> expression and the change of radiosensitivity of esophageal carcinoma cells显示文摘 | Qiang Tong Weiguo Zhang Shu Jin Shengbao Li Zihua Chen | 2011 | Scandinavian Journal of Gastroenterology2011，，2： | 1 |
| 6 | MicroRNA?133a inhibits proliferation and invasion, and induces apoptosisin gastric carcinoma cells via targeting fascin actin?bundling protein 1显示文摘 | Chen Lai Zihua Chen Ruixin Li | 2015 | Molecular Medicine Reports2015，，1： | 1 |
| 7 | Protective effects of baicalin on carbon tetrachloride induced liver injury by activating PPARγ and inhibiting TGFβ1显示文摘 | Hongxiang Qiao Hongcan Han Dongsheng Hong Zihua Ren Yan Chen Changxin Zhou | 2011 | Pharmaceutical Biology2011，，1： | 1 |
| 8 | The Electromagnetic Characteristics of UWB Signal Transmitting Through a Lossy Dielectric Slab 显示文摘 | CHEN Zhenqi YAO Richard and GUO Zihua | 2004 | IEEE VTC2004，，： | 1 |
| 9 | Surfactant assisted solvothermal synthesis of LiFePO4 nanorods for lithium-ion batteries显示文摘Well-shaped and uniformly dispersed LiFePO_4 nanorods with a length of 400–500 nm and a diameter of about 100 nm, are obtained with participation of a proper amount of anion surfactant sodium dodecyl sulfonate(SDS) without any further heating as a post-treatment. The surfactant acts as a self-assembling supermolecular template, which stimulated the crystallization of LiFePO_4 and directed the nanoparticles growing into nanorods between bilayers of surfactant(BOS). LiFePO_4 nanorods with the reducing crystal size along the b axis shorten the diffusion distance of Li^+ extraction/insertion, and thus improve the electrochemical properties of LiFePO_4 nanorods. Such prepared LiFePO_4 nanorods exhibited excellent specific capacity and high rate capability with discharge capacity of 151 mAh/g, 122 mAh/g and 95 mAh/g at 0.1C, 1 C and 5 C, respectively. Such excellent performance of LiFePO_4 nanorods is supposed to be ascribed to the fast Li^+ diffusion velocity from reduced crystal size along the b axis and the well electrochemical conductivity. The structure, morphology and electrochemical performance of the samples were characterized by XRD, FE-SEM, HRTEM, charge/discharge tests, and EIS(electrochemical impedance spectra). | Yuan Gao Ke Chen Hongmei Chen Xiaohua Hu Zihua Deng Zidong Wei | 2017 | Journal of Energy Chemistry2017，26，3： | 1 |
| 10 | The useful- ness of endoscopicuhrasound in the differential diagnosis between benign and malignant gastficulcer显示文摘 | Zhang Weiguo Tong Qiang Chen Zihua | 2010 | Scandinavian Journal of Gastroenterology2010，45，： | 1 |
| 11 | ATF4/TXNIP/REDD1/mTOR signaling mediates the antitumor activities of liver X receptor in pancreatic cancers显示文摘Background:Limited by difficulties in early detection and availabilities of effective treatments,pancreatic cancer is a highly malignant disease with poor prognosis.Nuclear receptors are a family of ligand‐dependent transcription factors that are highly druggable therapeutic targets playing critical roles in human physiological and pathological development,including cancer.In this study,we explored the therapeutic potential as well as the molecular mechanisms of liver X receptor(LXR)agonist GW3965 in pancreatic cancer.Methods:Soft‐agar colony formation assay,xenograft tumors,Oligonucleotide microarray,Reverse transcription real‐time polymerase chain reaction,Western immunoblotting and Immunohistochemistry were used in this study.Results:We demonstrated pleotropic in vitro activities of GW3965 in pancreatic cell lines MIA PaCa‐2 and BXPC3 including reduction of cell viability,inhibition of cell proliferation,stimulation of cell death,and suppression of colony formation,which translated to significant inhibition of xenograft tumor growth in vitro.By mapping the gene expression profiles,we identified the up‐regulations of 188 and the down‐regulations of 92 genes common to both cell lines following GW3965 treatment.Genes responsive to GW3965 represent a variety of biological pathways vital for multiple cellular functions.Specifically,we identified that the activating transcription factor 4/thioredoxin‐interacting protein/regulated in development and DNA damage responses 1/mechanistic target of rapamycin(ATF4/TXNIP/REDD1/mTOR)signaling critically controls GW3965‐mediated regulation of cell proliferation/death.The significance of the ATF4/TXNIP/REDD1/mTOR pathway was further supported by associated expressions in xenograft tumors as well as human pancreatic cancer samples.Conclusions:This study provides the pre‐clinical evidence that LXR agonist is a promising therapy for pancreatic cancer. | Zhikang Chen Xiaobo Lai Hui Ding Aijun Zhang Yufei Sun Jianhua Ling Paul J.Chiao Zihua Chen Xuefeng Xia | 2022 | Cancer Innovation2022，1，1： | 1 |
| 12 | Performance analysis of delayed acknowledgment scheme in UWB-based high-rate WPAN 显示文摘 | CHEN HONGYUAN GUO ZIHUA YAO R Y | 2006 | IEEE Transactions on Vehicular Technology2006，55，2： | 1 |
| 13 | A Clinicopathological Study on the Expression of Cadherin-17 and Caudal-related Homebox Transcription Factor (CDX-2) in Human Gastric Carcinoma显示文摘 | Jie Ge Zhikang Chen Shaobin Wu Weijie Yuan Bin Hu Zihua Chen | 2008 | Clinical Oncology2008，20，： | 1 |
| 14 | Experi- mental Study on Microwave NDT of Metal Pipeline Surface Defects 显示文摘 | YANG Chen DUAN Zihua MA Haitao | 2012 | Recent Advances in Computer Science and Information Engineering2012，128，： | 1 |
| 15 | Mechanism of E' center induced by γ ray radiation in silica optical fiber material显示文摘The characteristics of the best known defect centers E' in silica optical fiber material irradiated with ray were investigated by ESR at room temperature.A mechanism model of production of the E' center defect was established.The production of E' center includes two processes creation and activation.The strained bonds(or oxygen replacement) in silica networks lead to the creation of new defects whose concentration increases linearly with the dose.The pre-existing defects produce the activation,which tends to saturation.According to this model,the relation of E' center concentration changing with irradiation dose was obtained theoretically.The results are in good agreement with the experimental results. | LUO Wenyun XIAO Zhongyin WEN Jianxiang YIN Jianchong WU Wenkai CHEN Zhenyi WANG Zihua WANG Tingyun | 2013 | Nuclear Science and Techniques2013，24，4： | 0 |
| 16 | An ESIPT-based NIR-fluorescent probe for exosome labeling and in situ imaging显示文摘Exosomes play significant roles in physiological and tumorigenic processes and it is desirable to visualize and track the exosomes.Herein,a novel amphiphilic fluorescent probe HBT-Exo based on excited-state intramolecular proton transfer(ESIPT)mechanism is reported for exosome-labeling.Its ESIPT characteristics were confirmed by both theory calculation and experimental observation,which enable the probe to show a large Stokes shift as well as near-infrared(NIR)keto-form emission.HBT-Exo displayed excellent biocompatibility and remarkable efficiency for exosome-labeling in gastric cancer cells.Furthermore,the labeled exosomes were successfully applied for the real-time in situ imaging in mouse models. | Jipeng Ding Runsha Xiao Anyao Bi Guanyang Chen Nengwei Zhang Zihua Chen Xueping Feng Wenbin Zeng | 2023 | Chinese Chemical Letters2023，34，11： | 0 |
| 17 | 3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγSer273 phosphorylation in type 2 diabetic mice显示文摘3-Hydroxybutyrate(3HB)is a small ketone body molecule produced endogenously by the body in the liver.Previous studies have shown that 3HB can reduce blood glucose level in type 2 diabetic(T2D)patients.However,there is no systematic study and clear mechanism to evaluate and explain the hypoglycemic effect of 3HB.Here we demonstrate that 3HB reduces fasting blood glucose level,improves glucose tolerance,and ameliorates insulin resistance in type 2 diabetic mice through hydroxycarboxylic acid receptor 2(HCAR2).Mechanistically,3HB increases intracellular calcium ion(Ca^(2+))levels by activating HCAR2,thereby stimulating adenylate cyclase(AC)to increase cyclic adenosine monophosphate(cAMP)concentration,and then activating protein kinase A(PKA).Activated PKA inhibits Raf1 proto-oncogene serine/threonine-protein kinase(Raf1)activity,resulting in a decrease in extracellular signal-regulated kinases 1/2(ERK1/2)activity and ultimately inhibiting peroxisome proliferator-activated receptorγ(PPARγ)Ser273 phosphorylation in adipocytes.Inhibition of PPARγSer273 phosphorylation by 3HB altered the expression of PPARγregulated genes and reduced insulin resistance.Collectively,3HB ameliorates insulin resistance in type 2 diabetic mice through a pathway of HCAR2/Ca^(2+)/cAMP/PKA/Raf1/ERK1/2/PPARγ. | Yudian Zhang Zihua Li Xinyi Liu Xinyu Chen Shujie Zhang Yuemeng Chen Jiangnan Chen Jin Chen Fuqing Wu Guo-Qiang Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 18 | Growing Bigger——Chinese Banks Going Out显示文摘In November 2013,the Financial Stability Board(FSB)officially released the list of the year’s most important banks in the world.Fol-lowing the Bank of China,Industrial and Commercial Bank of China firstly ranked into this list.At the same time,a list of global top 100 banks was pub-lished by SNL Financial,where China’s four state-owned commercial | Cai Hongbo Chen Zihua | 2014 | China's Foreign Trade2014，，4： | 0 |
| 19 | Geological characteristics of the Nankai Trough subduction zone and their tectonic significances显示文摘The Nankai Trough subduction zone is a typical subduction system characterized by subduction of multiple geological units of the Philippine Sea Plate(the Kyushu-Palau Ridge,the Shikoku Basin,the Kinan Seamount Chain,and the Izu-Bonin Arc)beneath the Eurasian Plate in the southwest of Japan.This study presents a geophysical and geochemical analysis of the Nankai Trough subduction zone in order to determine the features and subduction effects of each geological unit.The results show that the Nankai Trough is characterized by lowgravity anomalies(–20 mGal to–40 mGal)and high heat flow(60–200 mW/m2)in the middle part and low heat flow(20–80 mW/m2)in the western and eastern parts.The crust of the subducting plate is 5–20 km thick.The mantle composition of the subducting plate is progressively depleted from west to east.Subduction of aseismic ridges(e.g.,the Kyushu-Palau Ridge,the Kinan Seamount Chain,and the Zenisu Ridge)is a common process that leads to a series of subduction effects at the Nankai Trough.Firstly,aseismic ridge or seamount chain subduction may deform the overriding plate,resulting in irregular concave topography along the front edge of the accretionary wedge.Secondly,it may have served as a seismic barrier inhibiting rupture propagation in the 1944 Mw 8.1 and 1946 Mw 8.3 earthquakes.In addition,subduction of the Kyushu-Palau Ridge and hot and young Shikoku Basin lithosphere may induce slab melting,resulting in adakitic magmatism and the provision of ore-forming metals for the formation of porphyry copper and gold deposits in the overriding Japan Arc.Based on comparisons of their geophysical and geochemical characteristics,we suggest that,although the Izu-Bonin Arc has already collided with the Japan Arc,the Kyushu-Palau Ridge,which represents a remnant arc of the Izu-Bonin Arc,is still at the subduction stage characterized by a single-vergence system and a topographic boundary with the Japan Arc. | Jie Zhang Ling Chen Zihua Cheng Limei Tang | 2020 | Acta Oceanologica Sinica2020，39，10： | 0 |
| 20 | A Direct Inspection of Displacement Current Using Phase Measurement显示文摘 | Zihua Weng Jinpan Zhu Jingyan He Zhimin Chen Huangping Yan Ying Weng | 2013 | 通讯和计算机(中英文版)2013，10，1： | 0 |
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