|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer显示文摘BACKGROUND The clinical significance of intratumoral human epidermal growth factor receptor 2(HER2)heterogeneity is unclear for HER2-positive gastric cancer,although it has been reported to be a significant prognosticator for HER2-positive breast cancer,which has received trastuzumab-based chemotherapy.AIM To clarify the clinical significance of intratumoral HER2 heterogeneity for HER2-positive gastric cancer,which has received trastuzumab-based chemotherapy.METHODS Patients with HER2-positive unresectable or metastatic gastric cancer who received trastuzumab-based chemotherapy as a first line treatment were included.The patients were classified into two groups according to their intratumoral HER2 heterogeneity status examined by immunohistochemistry(IHC)on endoscopic biopsy specimens before treatment,and their clinical response to chemotherapy and survival were compared.RESULTS A total of 88 patients were included in this study,and HER2 heterogeneity was observed in 23(26%)patients(Hetero group).The overall response rate was significantly better in patients without HER2 heterogeneity(Homo group)(Homo vs Hetero:79.5%vs 35.7%,P=0.002).Progression-free survival of trastuzumab-based chemotherapy was significantly better in the Homo group(median,7.9 vs 2.5 mo,HR:1.905,95%CI:1.109-3.268).Overall survival was also significantly better in the Homo group(median survival time,25.7 vs 12.5 mo,HR:2.430,95%CI:1.389-4.273).Multivariate analysis revealed IHC HER2 heterogeneity as one of the independent poor prognostic factors(HR:3.115,95%CI:1.610-6.024).CONCLUSION IHC of HER2 heterogeneity is the pivotal predictor for trastuzumab-based chemotherapy.Thus,HER2 heterogeneity should be considered during the assessment of HER2 expression. | Akio Kaito Takeshi Kuwata Masanori Tokunaga Kohei Shitara Reo Sato Tetsuo Akimoto Takahiro Kinoshita | 2019 | World Journal of Clinical Cases2019，7，15： | 5 |
| 2 | Testing Potential Effect of Environmental Endocrine Disruptors in Cow Milk on Reproductive Index in Female Rats显示文摘Objective To study the effect of endocrine disruptor chemicals in cow milk on female reproductive system. Methods A two-generation reproduction was conducted according to U. S. FDA standard. Milk was fed in special bottle to Wistar rats of both sexes through two successive generations (F0 and F1) in the milk group while artificial milk was fed to rats in the control group. Twenty-four rats of each sex were mated in each group. Measurements were made according to this guideline. Results Reproductive parameters in the milk group such as fertility index, gestation index, weights of uterus and ovary, days of vaginal opening, estrous cycles, histological morphological changes were comparable to those in the control group. However, the means of body weight had some differences. The body weight gains increased significantly in the milk-treated group in F1 and F2 generation compared with those in the control group. The concentration of insulin-like growth factor-1 (IGF-1) in blood in the milk group was comparable to that in the control group, but the standard deviation changed greatly in the milk-treated rats. Conclusion Endocrine disruptor chemicals in milk have no severe effects on the female reproductive system. | XIANG-MING LI DAVAASAMBUU GANMAA LI-QIANG QIN AKIO SATO | 2005 | Biomedical and Environmental Sciences2005，18，5： | 2 |
| 3 | Projection of global wanning onto regional precipitation over Mongolia using a regional climate model显示文摘 | Tomonori Sato Fujio Kimura Akio Kitoh | 2007 | Journal of Hydrology2007，333，1： | 1 |
| 4 | Growth inhibition of transplantable murine colon adenocarcinoma 38 by indomethacin显示文摘 | Makoto Sato Tomio Narisawa Masanori Sano Toshio Takahashi Akio Goto | 1983 | Journal of Cancer Research and Clinical Oncology1983，，1： | 1 |
| 5 | Liquefaction-Induced Lateral Load on Pile in a Medium Dr Sand Layer显示文摘 | Liangcai He Ahmed Elgamal Tarek Abdoun Akio Abe Ricardo Dobry Masanori Hamada Jorge Menses Masayoshi Sato Thomas Shantz Kohji Tokimatsu | 2009 | Journal of Earthquake Engineering2009，，7： | 1 |
| 6 | New low-molecular weight gelators based on L-valine andL-isoleucine with various terminal groups显示文摘 | Masahiro Suzuki Teruaki Sato Akio Kurose | 2005 | Tetrahedron Letters2005，46，： | 1 |
| 7 | Production of the Blood Pressure Lowing Peptides from Brown Alga(Undaria pinnatifida)显示文摘Brown alga (Undaria pinnatifida) was treated with alginate lyase and hydrolyzed using 17 kinds of proteases andthe inhibitory activity of the hydrolysates for the angiotensin-I-converting enzyme (ACE) was measured. Four hydrolysateswith potent ACE-inhibitory activity were administered singly and orally to spontaneously hypertensive rats (SHRs). The sys-tolic blood pressure of SHRs decreases significantly after single oral administration of the brown alga hydrolysates by pro-tease S ’Amano’ (from Bacillus stearothermophilus) at the concentration of 10 (mg protein) (kg body weight)-1. In the 17weeks of feeding experiment, 7-week-old SHRs were fed standard diet supplemented with the brown alga hydrolysates for 10weeks. In SHRs fed 1.0 and 0.1% brown alga hydrolysates, elevating of systolic bloodpressure was significantly suppressedfor 7 weeks. To elucidate the active components, the brown alga hydrolysates were fractionated by 1-butanol extraction andHPLC on a reverse-phase column. Seven kinds of ACE-inhibitory peptides were isolated and identified by amino acid compo-sition analysis, sequence analysis, and LC-MS with the results Val-Tyr, Ile-Tyr, Ala-Trp, Phe-Tyr, Val-Trp, Ile-Trp, andLeu-Trp. Each peptide was determined to have an antihypertensive effect after a single oral administration in SHRs. Thebrown alga hydrolysates were also confirmed to decrease the blood pressure in humans. | Sato Minoru Oba Takashi Hosokawa Takao Yamaguchi Toshiyasu Nakano Toshiki Saito Tadao Muramoto Koji Kahara Takashi Funayama Katsura Kobayashi Akio Nakano Takahisa | 2005 | Journal of Ocean University of China2005，4，3： | 1 |
| 8 | Potentiation of antitumor effect of NKT cell ligand, α-galactosylceramide by combination with IL-12 on lung metastasis of malignant melanoma cells1显示文摘 | Minoru Nakui Akio Ohta Masashi Sekimoto Marimo Sato Kenji Iwakabe Takashi Yahata Hidemitsu Kitamura Toshiaki Koda Tetsu Kawano Hiroyasu Makuuchi Masaru Taniguchi Takashi Nishimura | 2000 | Clinical and Experimental Metastasis2000，，2： | 1 |
| 9 | Estrogen: one of the risk factors in milk for prostate cancer显示文摘 | Li-Qiang Qin Pei-Yu Wang Takashi Kaneko Kazuhiko Hoshi Akio Sato | 2003 | Medical Hypotheses2003，，1： | 1 |
| 10 | Projection of global warming onto regional precipitation over Mongolia using a regional climate model显示文摘 | Tomonori Sato Fujio Kimura Akio Kitoh | 2007 | Journal of Hydrology2007，333，1： | 1 |
| 11 | New low molecular weight gelators based on L-valine and L-isoleucine with various terminal groups显示文摘 | Masahiro Suzuki Teruaki Sato Akio Kurose | 2005 | Tetrahedron Letters2005，46，2： | 1 |
| 12 | Evaluation of malignancy using Ki-67 labeling index for gastric stromal tumor显示文摘 | Yoshihide Nagasako Kazuhito Misawa Shigechika Kohashi Kimiharu Hasegawa Yumi Okawa Hidekazu Sano Akio Takada Hidetoshi Sato | 2003 | Gastric Cancer2003，，3： | 1 |
| 13 | Simulation of crosslink and graft mechanism of hydrogenated-NBR/zinc di-methacrylate composites by moving die rheometer显示文摘 | Takashi Sato Akio Fujino Sachio Hayashi Motofumi Oyama Katsumichi Ono | 2002 | Rubber Chemistry and Technology2002，75，5： | 1 |
| 14 | Tumor necrosis is a strong predictor for recurrence in patients withpathological T1a renal cell carcinoma显示文摘 | Keiichi Ito Kenji Seguchi Hideyuki Shimazaki Eiji Takahashi Shinsuke Tasaki Kenji Kuroda Akinori Sato Junichi Asakuma Akio Horiguchi Tomohiko Asano | 2015 | Oncology Letters2015，，1： | 1 |
| 15 | Reflex modulation of visceral functions by acupuncture-like stimulation in anesthetized rats显示文摘 | Akio Sato Yuko Sato Sae Uchida | 2002 | Int Cong Ser2002，1238，： | 1 |
| 16 | 牛奶中雌激素类化合物对前列腺和睾丸的影响显示文摘目的 :研究牛奶中雌激素样物质对男性生殖系统的影响。 方法 :利用世界五大洲肿瘤发病数据库和联合国粮农组织 (FAO)数据库 ,对 42个国家 (地区 )前列腺癌和睾丸癌发病率 ( 1988~ 1992 )与相应的食物消费量资料 ( 1961~ 1990 )进行相关分析 ;根据美国食品药品管理局 (FDA)标准 ,选用Wistar大鼠 ,进行两代繁殖实验 ,主要研究牛奶中雌激素化合物对生殖器官的影响。 结果 :在所分析的食物中 ,前列腺癌与牛奶消费量的关系最密切(r =0 .711) ,其次是肉类与咖啡 ;奶酪与 2 0~ 3 9岁的睾丸癌标化发病率关系最密切 (r =0 .80 4) ,其次是动物性脂肪和牛奶 ;动物实验研究发现 ,大鼠经长期、大量地饮用牛奶后 ,未发现生殖器官明显减轻的现象。 结论 | 李湘鸣 Davaasambuu Ganmaa 秦立强 刘秀梵 Akio Sato | 2003 | 中华男科学杂志2003，9，3： | 1 |
| 17 | New low molecular weight gelators based on L-valine and L-isoleucine with various terminal groups显示文摘 | Masahiro Suzuki Teruaki Sato Akio Kurose | 2005 | Tetrahedron Letters2005，46，2： | 1 |
| 18 | Neural mechanisms of autonomic responses elicited by somatic sensory stimulation显示文摘 | Akio Sato | 1997 | Neuroscience and Behavioral Physiology1997，，5： | 1 |
| 19 | Modulation of somatocardiac sympathetic reflexes mediated by opioid receptors at the spinal and brainstem level显示文摘 | Akio Sato Yuko Sato Robert F. Schmidt | 1995 | Experimental Brain Research1995，，1： | 1 |
| 20 | IgG4-related Sclerosing Cholangitis With and Without Hepatic Inflammatory Pseudotumor, and Sclerosing Pancreatitis-associated Sclerosing Cholangitis: Do They Belong to a Spectrum of Sclerosing Pancreatitis?显示文摘 | Yoh Zen Kenichi Harada Motoko Sasaki Yasunori Sato Koichi Tsuneyama Joji Haratake Hiroshi Kurumaya Kazuyoshi Katayanagi Shinji Masuda Hideki Niwa Hideo Morimoto Atsuo Miwa Akio Uchiyama Bernard C Portmann Yasuni Nakanuma | 2004 | The American Journal of Surgical Pathology2004，，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员