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| 1 | Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring显示文摘树鼯有一种靠近的关系到首领并且在生物医学的研究比啮齿类动物有许多优点。然而,基因操作方法的缺乏妨碍了这个动物的更宽的使用。Spermatogonial 干细胞(SSC ) 成功地在文化被扩展了允许复杂基因在老鼠和老鼠编辑。这里,没有干细胞性质的损失,我们为树鼯 SSC 的长期的扩大描述一个文化系统。在我们的学习,胸腺房间抗原 1 被用来充实树鼯 SSC。定序 RNA 分析表明表明小径的 Wnt/-catenin 在无差别的 SSC 是活跃的,但是是在 SSC 区别的开始之上的 downregulated。树鼯的暴露到 recombinant Wnt3a 蛋白质的主要 SSC 在文化的起始的段落期间提高了 SSC 的幸存。当 feeder 被发现为树鼯 SSC 增长必要,树鼯 Sertoli 房间,然而并非老鼠使用胚胎的成纤维细胞,导致柔韧的房间扩大和长期的文化。扩展的树鼯 SSC 是有提高的绿色的 transfected 荧光灯表示 lentiviral 向量的蛋白质(EGFP ) 。在进消毒的成年的男树鼯睾丸的移植以后,标注 EGFP 的 SSC 能恢复精子发生并且成功地产生转基因的后代。而且,这些 SSC 对 CRISPR/Cas9-mediated 基因修正合适。在有编辑的基因的联合的树鼯 SSC 接近膨胀的一个文化系统的发展用树鼯为精确染色体操作铺平道路。 | Chao-Hui Li Lan-Zhen Yan Wen-Zan Ban Qiu TH Yong Wu Lin Wang Rui Bi Shuang Ji Yu-Hua Ma Wen-Hui Nie Long-Bao Lv Yong-Gang Yao Xu-Dong Zhao Ping Zheng | 2017 | Cell Research2017，27，2： | 22 |
| 2 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 3 | Effect of BN52021 on NFκ-Bp65 expression in pancreatic tissues of rats with severe acute pancreatitis显示文摘AIM: To investigate dynamic changes and significance of expression of NF-κBp65 in pancreatic tissues of rats with severe acute pancreatitis (SAP), as well as BN52021 effects. METHODS: Wistar male rats were randomly divided into negative control group (NC group, n = 60), SAP-model group (SAP group, n = 60), and BN52021-treated group (BN group, n = 60), and each of the above groups was respectively divided into 6 subgroups at different time points after operation (1 h, 2 h, 3 h, 6 h, 12 h, and 24 h) (n = 10). By RT-PCR and Western blot, NF-κBp65 mRNA and its protein expression in pancreatic tissues of rats were detected respectively. RESULTS: The expression of NF-κBp65 mRNA dynamically changed in both SAP groups and BN groups. The mRNA level was higher in SAP groups than NC groups at 2 h, 3 h, 12 h, and 24 h after operation (P < 0.05), higher in BN groups than NC groups at all time points (P < 0.05), and higher in BN groups than SAP group at 1 h (P < 0.05). The NF-κBp65 protein level was higher in SAP groups than NC groups at 1 h, 3 h, and 6 h (P < 0.01), and 2 h, 12 h, and 24 h (P < 0.05), higher in BN groups than NC groups at all time points (P < 0.05), and lower in BN groups than SAP groups at 1 h, 3 h, and 6 h (P < 0.05). CONCLUSION: The expression of NF-κBp65 in pancreatic tissues is dynamically changed and the changes play an important role in pathogenesis of SAP. BN52021 exerts therapeutic effects through reducing the expression level of NF-κBp65 protein in the early stage of SAP. | Shi-Hai Xia Dian-Chun Fang Chun-Xiu Hu Hui-Ying Bi Yin-Zhi Yang Yao Di | 2007 | World Journal of Gastroenterology2007，13，6： | 13 |
| 4 | Evaluation of the simulation capability of the Wavewatch Ⅲ model for Pacific Ocean wave显示文摘Wave climate analysis and other applications for the Pacific Ocean require a reliable wave hindcast. Five source and sink term packages in the Wavewatch III model(v3.14 and v4.18) are compared and assessed in this study through comprehensive observations, including altimeter significant wave height, advanced synthetic aperture radar swell, and buoy wave parameters and spectrum. In addition to the evaluation of typically used integral parameters, the spectra partitioning method contributes to the detailed wave system and wave maturity validation. The modified performance evaluation method(PS) effectively reduces attribute numbers and facilitates the overall assessment. To avoid possible misleading results in the root mean square error-based validations, another indicator called HH(indicating the two authors) is also calculated to guarantee the consistency of the results. The widely used Tolman and Chalikov(TC) package is still generally efficient in determining the integral properties of wave spectra but is physically deficient in explaining the dissipation processes. The ST4 package performs well in overall wave parameters and significantly improves the accuracy of wave systems in the open ocean. Meanwhile, the newly published ST6 package is slightly better in determining swell energy variations. The two packages(ACC350 and BJA) obtained from Wavewatch III v3.14 exhibit large scatters at different sea states. The three most ideal packages are further examined in terms of reproducing waveinduced momentum flux from the perspective of transport. Stokes transport analysis indicates that ST4 is the closest to the NDBC-buoy-spectrum-based transport values, and TC and ST6 tend to overestimate and underestimate the transport magnitude, respectively, in swell mixed areas. This difference must be considered,particularly in air–wave–current coupling research and upper ocean analysis. The assessment results provide guidance for the selection of ST4 for use in a background Pacific Ocean hindcast for high wave climate research and China Sea swell type analysis. | BI Fan SONG Jinbao WU Kejian XU Yao | 2015 | Acta Oceanologica Sinica2015，34，9： | 10 |
| 5 | SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer显示文摘SIRT7,a sirtuin family member implicated in aging and disease,is a regulator of metabolism and stress responses.It remains elusive how human somatic stem cell populations might be impacted by SIRT7.Here,we found that SIRT7 expression declines during human mesenchymal stem cell(hMSC)aging and that SIRT7 deficiency accelerates senescence.Mechanistically,SIRT7 forms a complex with nuclear lamina proteins and heterochromatin proteins,thus maintaining the repressive state of heterochromatin at nuclear periphery.Accordingly,deficiency of SIRT7 results in loss of heterochromatin,derepression of the LINE1 retrotransposon(LINE1),and activation of innate immune signaling via the cGAS-STING pathway.These agingassociated cellular defects were reversed by overexpression of heterochromatin proteins or treatment with a LINE1 targeted reverse-transcriptase inhibitor.Together,these findings highlight how SIRT7 safeguards chromatin architecture to control innate immune regulation and ensure geroprotection during stem cell aging. | Shijia Bi Zunpeng Liu Zeming Wu Zehua Wang Xiaoqian Liu Si Wang Jie Ren Yan Yao Weiqi Zhang Moshi Song Guang-Hui Liu Jing Qu | 2020 | Protein & Cell2020，11，7： | 10 |
| 6 | Zoonotic origins of human coronavirus 2019(HCoV-19/SARS-CoV-2):why is this work important?显示文摘The ongoing pandemic of coronavirus disease 2019 (COVID-19), caused by infection with human coronavirus 2019 (HCoV-19/SARS-CoV-2/2019-nCoV), is a global threat to the human population. Here, we briefly summarize the available data for the zoonotic origins of HCoV-19, with reference to the other two epidemics of highly virulent coronaviruses, SARSCoV and MERS-CoV, which cause severe pneumonia in humans. We propose to intensify future efforts for tracing the origins of HCoV-19, which is a very important scientific question for the control and prevention of the pandemic. | Gary Wong Yu-Hai Bi Qi-Hui Wang Xin-Wen Chen Zhi-Gang Zhang Yong-Gang Yao | 2020 | Zoological Research2020，41，3： | 10 |
| 7 | Biochemical sensing in graphene-enhanced microfiber resonators with individual molecule sensitivity and selectivity显示文摘Photonic sensors that are able to detect and track biochemical molecules offer powerful tools for information acquisition in applications ranging from environmental analysis to medical diagnosis.The ultimate aim of biochemical sensing is to achieve both quantitative sensitivity and selectivity.As atomically thick films with remarkable optoelectronic tunability,graphene and its derived materials have shown unique potential as a chemically tunable platform for sensing,thus enabling significant performance enhancement,versatile functionalization and flexible device integration.Here,we demonstrate a partially reduced graphene oxide(prGO)inner-coated and fiber-calibrated Fabry-Perot dye resonator for biochemical detection.Versatile functionalization in the prGO film enables the intracavity fluorescent resonance energy transfer(FRET)to be chemically selective in the visible band.Moreover,by measuring the intermode interference via noise canceled beat notes and locked-in heterodyne detection with Hz-level precision,we achieved individual molecule sensitivity for dopamine,nicotine and single-strand DNA detection.This work combines atomic-layer nanoscience and high-resolution optoelectronics,providing a way toward high-performance biochemical sensors and systems. | Zhongxu Cao Baicheng Yao Chenye Qin Run Yang Yanhong Guo Yufeng Zhang Yu Wu Lei Bi Yuanfu Chen Zhenda Xie Gangding Peng Shu-Wei Huang Chee Wei Wong Yunjiang Rao | 2019 | Light(Science & Applications)2019，8，1： | 8 |
| 8 | Role of interleukin-8 in the progression of estrogen receptor-negative breast cancer显示文摘背景雌激素受体(嗯) 是乳癌的很重要的 biomarker。嗯删除一致地与肿瘤前进,复发,转移和差的预后被联系了,但是生物机制仍然是不清楚的。嗯 interieukin-8 (IL-8 ) 的否定乳癌快车高水平。嗯表示罐头 downregulate IL-8 promotor 活动。作为多功能的 cytokine, IL-8 在肿瘤开始和开发举办许多重要生物活动。旨在在嗯否定的乳癌前进调查 IL-8 的角色,我们把 RNA 干扰技术用于明确地击倒在房间线 MDA-MB-231.Methods 介入 pRNA-IL-8 和控制是的嗯否定的乳癌的 IL-8 表示 transfected 进嗯(-) MDA-MB-231。增长,房间 apotosis,和侵略能力在 transfected, untransfected 和否定 transfected 房间被记录。这些房间被注入裸体鼠标估计 tumorigenicity,增长,转移和 microvessel 密度(MVD ) 在 vitro 的 .Results, IL-8 的减少的表示与被联系减少了房间侵略(P0.001 ) ,但是没在房间增长(P0.05 ) 上有效果。在 vivo, neutrophils 渗入显著地与 untransfected 相比并且否定地在 pRNA-IL-8 transfected 房间被禁止 transfected 房间(P=0.001, P0.001 ) 。更少的转移在 transfected 房间被发现与相比否定地 transfected 房间(0% 对 80% , P=0.048 ) 。不过,我们与控制相比在 transfected 房间观察了更少的 MVD 在里面裸体老鼠(P0.001 ).Conclusions IL-8 禁止嗯否定的乳癌房间生长并且在 vivo 支持它的转移,它可以被相关, neutrophils 渗入由 IL-8 导致了。 | YAO Chen LIN Ying YE Cai-sheng BI Jiong ZHU Yi-fan WANG Shen-ming | 2007 | Chinese Medical Journal2007，，20： | 8 |
| 9 | Organic photovoltaic cell with 17% efficiency and superior processability显示文摘The development of organic photoactive materials,especially the newly emerging non-fullerene electron acceptors(NFAs),has enabled rapid progress in organic photovoltaic(OPV)cells in recent years.Although the power conversion efficiencies(PCEs)of the top-performance OPV cells have surpassed 16%,the devices are usually fabricated via a spin-coating method and are not suitable for large-area production.Here,we demonstrate that the fine-modification of the flexible side chains of NFAs can yield 17%PCE for OPV cells.More crucially,as the optimal NFA has a suitable solubility and thus a desirable morphology,the high efficiencies of spin-coated devices can be maintained when using scalable blade-coating processing technology.Our results suggest that optimization of the chemical structures of the OPV materials can improve device performance.This has great significance in larger-area production technologies that provide important scientific insights for the commercialization of OPV cells. | Yong Cui Huifeng Yao Ling Hong Tao Zhang Yabing Tang Baojun Lin Kaihu Xian Bowei Gao Cunbin An Pengqing Bi Wei Ma Jianhui Hou | 2020 | National Science Review2020，7，7： | 7 |
| 10 | Climate and extrema of ocean waves in the East China Sea显示文摘Wave climate plays an important role in the air-sea interaction over marginal seas. Extreme wave height provides fundamental information for various ocean engineering practices, such as hazard mitigation, coastal structure design, and risk assessment. In this paper, we implement a third generation wave model and conduct a high-resolution wave hindcast over the East China Sea to reconstruct a 15-year wave field from 1988 to 2002 for derivation of monthly mean wave parameters and analysis of extreme wave conditions. The numerical results of the wave field are validated through comparison with satellite altimetry measurements, low-resolution reanalysis, and the ocean wave buoy record. The monthly averaged wave height and wave period show seasonal variation and refined spatial patterns of surface waves in the East China Sea. The climatological significant wave height and mean wave period decrease from the open ocean in the southeast toward the continental area in the northwest, with the pattern generally following the bathymetry. Extreme analysis on the significant wave height at the buoy station indicates the hindcast data underestimate the extreme values relative to the observations. The spatial pattern of extreme wave height shows single peak emerges at the southwest of Ryukyu Island although a wind forcing with multi-core structure at the extreme is applied. | Hailun HE Jinbao SONG Yefei BAI Yao XU Juanjuan WANG Fan BI | 2018 | Science China Earth Sciences2018，61，7： | 7 |
| 11 | Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese显示文摘Alzheimer's disease is the most common neurodegenerative disease,and has a high level of genetic heritability and population heterogeneity.In this study,we performed the whole-exome sequencing of Han Chinese patients with familial and/or early-onset Alzheimer's disease,followed by independent validation,imaging analysis and function characterization.We identified an exome-wide significant rare missense variant rs3792646(p.K420Q)in the C7 gene in the discovery stage(P=1.09×10^(-6),odds ratio=7.853)and confirmed the association in different cohorts and a combined sample(1615 cases and 2832 controls,P_(combined)=2.99×10^(-7),odds ratio=1.930).The risk allele was associated with decreased hippocampal volume and poorer working memory performance in early adulthood,thus resulting in an earlier age of disease onset.Overexpression of the mutant p.K420Q disturbed cell viability,immune activation and β-amyloid processing.Electrophysiological analyses showed that the mutant p.K420Q impairs the inhibitory effect of wild type C7 on the excitatory synaptic transmission in pyramidal neurons.These findings suggested that C7 is a novel risk gene for Alzheimer’s disease in Han Chinese. | Deng-Feng Zhang Yu Fan Min Xu Guihong Wang Dong Wang Jin Li Li-Li Kong Hejiang Zhou Rongcan Luo Rui Bi Yong Wu Guo-Dong Li Ming Li Xiong-Jian Luo Hong-Yan Jiang Liwen Tan Chunjiu Zhong Yiru Fang Chen Zhang Nengyin Sheng Tianzi Jiang Yong-Gang Yao | 2019 | National Science Review2019，6，2： | 6 |
| 12 | Salinity and Persistent Toxic Substances in Soils from Shanghai,China显示文摘Some farmland soils in Shanghai had high salinity levels, suggesting secondary salinization of the soils. The soil problems in Shanghai were studied, including the salinity and nitrate nitrogen (NO -3 -N) concentrations, heavy metal pollution characteristics, and organochlorine pesticide (OCP) residual levels and polycyclic aromatic hydrocarbon (PAH) contents. Accumulation of NO -3 -N in vegetable soils was the most significant among different functional soils. Heavy metal pollution was significant in the samples collected from the sewage-irrigated land and roadside. The identification of the metal sources through multivariate statistical analysis indicated that Pb, Zn, Cu and Cr in urban soils were from the traffic pollutants; excessive application of fertilizer and irrigation were the main reasons for the metal pollution in agricultural soils; Ni in the observed soils was controlled by parent soils. OCPs could still be detected in farmland soils but degraded greatly in last 20 years after prohibition of their usage. PAHs with 2-3 rings were the main components in industrial soils. The concentrated PAHs in the investigated soils were likely from petroleum and coal combustion. | SHI Gui-Tao CHEN Zhen-Lou XU Shi-Yuan YAO Chun-Xia BI Chun-Juan WANG Li | 2009 | Pedosphere2009，19，6： | 5 |
| 13 | Characteristics of soil organic carbon and total nitrogen under various grassland types along a transect in a mountain-basin system in Xinjiang, China显示文摘Soil organic carbon(SOC) and soil total nitrogen(STN) in arid regions are important components of global C and the N cycles, and their response to climate change will have important implications for both ecosystem processes and global climate feedbacks. Grassland ecosystems of Funyun County in the southern foot of the Altay Mountains are characterized by complex topography, suggesting large variability in the spatial distribution of SOC and STN. However, there has been little investigation of SOC and STN on grasslands in arid regions with a mountain-basin structure. Therefore, we investigated the characteristics of SOC and STN in different grassland types in a mountain-basin system at the southern foot of the Altai Mountains, north of the Junggar Basin in China, and explored their potential influencing factors and relationships with meteorological factors and soil properties. We found that the concentrations and storages of SOC and STN varied significantly with grassland type, and showed a decreasing trend along a decreasing elevation gradient in alpine meadow, mountain meadow, temperate typical steppe, temperate steppe desert, and temperate steppe desert. In addition, the SOC and STN concentrations decreased with depth, except in the temperate desert steppe. According to Pearson's correlation values and redundancy analysis, the mean annual precipitation, soil moisture content and soil available N concentration were significantly positively correlated with the SOC and STN concentrations. In contrast, the mean annual temperature, p H, and soil bulk density were significantly and negatively correlated with the SOC and STN concentrations. The mean annual precipitation and mean annual temperature were the primary factors related to the SOC and STN concentrations. The distributions of the SOC and STN concentrations were highly regulated by the elevation-induced differences in meteorological factors. Mean annual precipitation and mean annual temperature together explained 97.85% and 98.38% of the overall variations in the SOC and STN concentrations, respectively, at soil depth of 0–40 cm, with precipitation making the greatest contribution. Our results provide a basis for estimating and predicting SOC and STN concentrations in grasslands in arid regions with a mountain-basin structure. | BI Xu LI Bo NAN Bo FAN Yao FU Qi ZHANG Xinshi | 2018 | Journal of Arid Land2018，10，4： | 4 |
| 14 | Expression and Purification of Recombinant Hepatitis Delta Virus(HDV) Antigen for Use in a Diagnostic ELISA for HDV Infection Using the High-Density Fermentation Strategy in Escherichia coli显示文摘Objective Hepatitis Delt a Virus(HDV) antigen is widely used as a capture antigen in ELISAs for the identification of HDV infection; large amounts of recombinant HDV antigen with active antigenicity are required for this purpose. Methods Reconstruct the gene of HDV antigen based on the bias code of Escherichia coli, the recombinant protein expresses by high-density fermentation with fed-batch feeding strategy, and purify by immobilized metal chromatography. The sensitivity and specificity of this antigen detect by ELISA method. Results The expression of HDV antigen can reach 20% of the total cell mass in the soluble form. The recombinant HDV antigen can be conveniently purified(98%) by immobilized metal ion affinity chromatography(IMAC) using the interaction between a His-tag and nickel ions. Production of recombinant HDV antigen can reach 0.5 g/L under conditions of high-density cell fermentation. Applied to the diagnostic ELISA method, the recombinant HDV antigen shows excellent sensitivity(97% for IgM and 100% for IgG) and specificity(100% for IgG and IgM) for the detection of anti-HDV antibodies. Conclusion Expression and purification the recombinant HDV antigen as a candidate protein for application in a diagnostic ELISA for HDV infection. Large-scale production of the protein can be achieved using the high-density fermentation strategy. | LU Xue Xin YI Yao SU Qiu Dong BI Sheng Li | 2016 | Biomedical and Environmental Sciences2016，29，6： | 4 |
| 15 | Modeling of Cross-Spring Pivots Subjected to Generalized Planar Loads显示文摘Cross-spring pivots, formed by crossing two identical flexural beams at their midpoint, have been broadly used in precision engineering and aerospace fields. Many researches have been conducted on modeling and analysis of cross-spring pivots. However the influence of application position and magnitude of the external loads on the load-rotation and parasitic motion characteristics has not yet been discussed. In order to reveal the effect of the external loads, this paper develops the accurate load-rotation and center shift models of cross-spring pivots, with generalized planar loads applied including bending moment, horizontal and vertical forces. Firstly, by using the energy method, the load-displacement models of the pivot are derived with the assumption of small rotational angles. Based on the models, the influence of generalized planar loads on the load-rotation relationship is discussed, which shows that both application position and magnitude of the vertical and horizontal forces influence the load-rotation behaviors. Then the accurate center shift expressions of the pivot with generalized planar loads are developed, which shows that the rotational angle is the dominant term for both components of the center shift while the vertical and horizontal forces are small. Finally, the accuracy of the proposed model is validated by finite element analysis(FEA). Comparing the model data with the results obtained from FEA, the relative error of the load-rotation is less than 6% even if the rotational angle reaches 20°; the relative errors of the two components of center shift are less than 5% and 10% respectively when the rotational angle reaches 10°. The proposed model and analytical conclusions can be used to analyze and preliminarily design the compliant mechanisms containing cross-spring pivots. | BI Shusheng YAO Yanbin ZHAO Shanshan YU Jingjun | 2012 | Chinese Journal of Mechanical Engineering2012，25，6： | 4 |
| 16 | Preparation of Polycarboxylate-based Superplasticizer and Its Effects on Zeta Potential and Rheological Property of Cement Paste显示文摘A series of polycarboxylate-based superplasticizers(PCs) with different structures were synthesized and the effects of chemical structure on zeta potential and rheological property of cement paste were studied. Residual monomers in each sample of PCs were quantitatively determined. The property of the polymers in cement was tested by micro-electrophoresis apparatus and R/S rheometer. Results showed that the zeta potential and its rheological properties are related with the side-chain length and density of PCs. The PCs having shorter side chain and lower side chain density exhibit higher anionic charge density, thus resulting in higher zeta potential. The effect of side chain density on zeta potential is more notable compared with that of side-chain length, and thus affecting the initial shear yield stress and apparent viscosity of the cement paste. In addition, although increasing the side chain length will result in reduction of the anionic charge density, the steric hindrance effect is obvious, which can effectively improve the dispersion of the cement particles, and reduce the viscosity and shear yield stress of slurry. | 刘明 雷家珩 BI Yao DU Xiaodi ZHAO Qinglin ZHANG Xuqing | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，5： | 3 |
| 17 | Association between Selenium in Soil and Diabetes in Chinese Residents Aged 35–74 Years:Results from the 2010 National Survey of Chronic Diseases and Behavioral Risk Factors Surveillance显示文摘Objective To explore the association between soil selenium levels and the risk of diabetes in Chinese adults aged 35–74 years.Methods Data for this study were derived from the China Chronic Diseases and Behavioral Risk Factors Surveillance 2010 survey.Selenium concentrations in soil were obtained from the Atlas of Soil Environmental Background Values in China.A two-level binary logistic regression model was used to determine the association between soil selenium concentrations and the risk of diabetes,with participants nested within districts/counties.Results A total of 69,332 participants aged 35–74 years,from 158 districts/counties were included in the analysis.Concentrations of selenium in soil varied greatly across the 158 districts/counties,with a median concentration of 0.219 mg/kg(IQR:0.185–0.248).The results showed that both Quartile 1(0.119–0.185 mg/kg)and Quartile 4(0.249–0.344 mg/kg)groups were positively associated with diabetes compared to a soil selenium concentration of 0.186–0.219 mg/kg(Quartile 2),crude odds ratios(ORs)(95%CI)were 1.227(1.003–1.502)and 1.280(1.048–1.563).The P values were 0.045 and 0.013,for Quartile 1 and Quartile 4 groups,respectively.After adjusting for all confounding factors of interest,the Quartile 1 group became non-significant,and the Quartile 4 group had an adjusted OR(95%CI)of 1.203(1.018–1.421)relative to the reference group(Quartile 2),the P values was 0.030.No significant results were seen for the Quartile 3 group(0.220–0.248 mg/kg)compared to the reference group.Conclusion Excessive selenium concentrations in soil could increase the risk of diabetes among Chinese adults aged 35–74 years. | WANG Qi Qi YU Shi Cheng XU Cheng Dong LIU Jian Jun LI Yuan Qiu ZHANG Man Hui LONG Xiao Juan LIU Yun Ning BI Yu Fang ZHAO Wen Hua YAO Hong Yan | 2020 | Biomedical and Environmental Sciences2020，33，4： | 3 |
| 18 | Optical frequency divider with division uncertainty at the 10^(-21) level显示文摘Optical clocks with unprecedented accuracy of 10^(-18) promise innovations in many research areas.heir applications rely to a large extent on the ability of precisely converting the frequency from one optical clock to another,or particularly to the frequencies in the iber telecom band for long-distance transmission.his report demonstrates a low-noise,high-precision optical frequency divider,which realizes accurate optical frequency conversion and enables precise measurement of optical frequency ratios.By measuring against the frequency ratio between the fundamental and the second harmonic of a 1064-nm laser instead of a second copy of the same system,we demonstrate that the optical frequency divider has a fractional frequency division instability of 6×10^(-19) at 1 s and a fractional frequency division uncertainty of 1.4×10^(-21).he remarkable numbers can support frequency division of the best optical clocks in the world without frequency-conversion-caused degradation of their performance. | Yuan Yao Yanyi Jiang Hongfu Yu Zhiyi Bi Longsheng Ma | 2016 | National Science Review2016，3，4： | 3 |
| 19 | The temporal and spatial variations in the Pacific wind and wave fields for the period 2002–2011显示文摘The temporal and spatial variations in the wind and wave fields in the Pacific Ocean between 2002 and 2011 are analyzed using a third-generation wave model(WAVEWATCH III). The model performance for a significant wave height is validated using in situ buoy data. The results show that the wave model effectively hindcasts the significant wave height in the Pacific Ocean, but the errors are relatively large in the mid- and low-latitude regions. The spatial distributions and temporal variations in a wind speed and the significant wave height in the Pacific Ocean are then considered after dividing the Pacific Ocean into five regions, which show meridional differences and seasonal cycles. Regional mean values are used to give yearly average time series for each separate zone. The high latitude region in the Southern Hemisphere had a stronger significant wave height trend in the model results than regions at other latitudes. The sources and sinks of wave energy are then investigated. Their regional mean values are used to quantify variations in surface waves. Finally, the spectral analyses of the daily mean wind speeds and the significant wave heights are obtained. The significant wave height and the wind speed spectra are found to be connected in some ways but also show certain differences. | XU Yao BI Fan SONG Jinbao HE Hailun | 2017 | Acta Oceanologica Sinica2017，36，3： | 3 |
| 20 | Hepatitis B Immunoprophylactic Failure and Characteristics of the Hepatitis B Virus Gene in Mother-Infant Pairs in Parts of China显示文摘Objective To determine the hepatitis B immunoprophylactic failure rate in infants born to hepatitis B virus(HBV) infected mothers and to characterize HBV genes. Methods HBV-serological testing was conducted for pregnant women and infants. The complete genomes of 30 HBV isolates were sequenced, and genetic characteristics were analyzed using MEGA 5 software. Results The immunoprophylactic failure rate for infants who had completed the scheduled hepatitis B vaccination program was 5.76%(32/556). High sequence homology(99.8%-100%) was observed in 8 of the 10 mother-infant pairs. We identified 19 subgenotype C2 strains, 9 subgenotype B2 strains, and 2 subgenotype C1 strains. Three serotypes were detected: adr(19/30), adw(9/30), and ayw(2/30). The frequency of amino acid mutation of the ‘a' determinant region was 16.67%(5/30), including that of Q129 H, F134 Y, S136 Y, and G145 E. We detected 67 amino acid mutations in the basal core promoter, precore, and core regions of the genome. Conclusion The immunoprophylactic failure rate in infants born to HBV-infected mothers is low in the regions of China examined during this study. Moreover, HBV mutation in the ‘a' determinant region could not account for immunoprophylactic failure for all infants. | YIN Wen Jiao SHEN Li Ping WANG Fu Zhen ZHANG Guo Min ZHENG Hui WANG Feng LIU Tie Zhu MENG Qing Ling YI Yao CUI Fu Qiang BI Sheng Li | 2016 | Biomedical and Environmental Sciences2016，29，11： | 3 |
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