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| 1 | Neurons secrete miR-132.containing exosomes to regulate brain vascular integrity显示文摘脉管的完整帮助维持大脑微型环境动态平衡,它为中央神经系统的正常开发和函数是批评的。神经房间能调整大脑,这被知道脉管的正直。由于包含的神经与血管的相互作用的高复杂性,不管多么大脑的神经规定理解脉管的正直仍然是原始的。用未经触动的 zebrafish 幼虫和有教养的啮齿类动物大脑房间,我们发现神经原转移 miR-132,一高度保存了并且充实神经原的 microRNA,经由到 endothelial 房间(EC ) 到的 secreting exosomes 维持大脑脉管的正直。后面的 translocation 到通过 exosome 成为主观的 EC, miR-132 调整脉管的 endothelial cadherin (VE-cadherin ) 的表示,重要 adherens 连接蛋白质,由直接指向真核细胞的延伸因素 2 kinase (eef2k ) 。neuronal miR-132 表示或 exosome 分泌物的混乱,或脉管的 eef2k 的 overexpression 损害 VE-cadherin 表示和大脑脉管的正直。我们的学习显示 miR-132 作为调停的一个细胞间的信号扮演大脑的神经规定脉管的完整并且建议 neuronal exosome 是为神经与血管的通讯的一条新奇大街。 | Bing Xu Yu Zhang Xu-Fei Du Jia Li Hua-Xing Zi Ji-Wen Bu Yong Yan Hua Han Jiu-Lin Du | 2017 | Cell Research2017，27，7： | 46 |
| 2 | Therapeutic effect of Zijin capsule in liver fibrosis in rats显示文摘TherapeuticefectofZijincapsuleinliverfibrosisinratsCAIDaYongZHAOGang,CHENJiaChun,YEGanMei,BINGFeiHongandFANBuWuSubjecth... | CAI Da Yong, ZHAO Gang, CHEN Jia Chun, YE Gan Mei, BING Fei Hong and FAN Bu Wu | 1998 | World Journal of Gastroenterology1998，4，3： | 20 |
| 3 | Infantile hepatic hemangioendothelioma:A clinicopathologic study in a Chinese population显示文摘AIM:To investigate whether the clinicopathologic features of infantile hemangioendothelioma(IHE) of the liver in a Chinese population are similar to the features observed in other races.METHODS:The clinical data,radiological findings,histopathological changes and outcome of 12 cases of IHE diagnosed by the Department of Pathology,West China Hospital over the last 10 years were analyzed retrospectively.Immunohistochemical studies were carried out using antibodies against CD31,CD34,Factor Ⅷ,cytokeratin 8 and cytokeratin 18.RESULTS:The 12 patients were aged from fetal to 5 years(three males and nine females).The tumor was presented with different clinical manifestations,mainly as an asymptomatic,palpable,upper abdominal mass,except for the two fetuses who were detected antena-tally by ultrasound.In one patient,this presentation was accompanied by an initial severe pneumothorax.No symptoms of congestive heart failure were present and neither congenital abnormalities nor vascular tumors in the skin or other organs were found.Laboratory abnormalities included leukocytosis(40%),anemia(60%),thrombocytosis(60%),hyperbilirubinemia(16.7%),abnormal liver function(50%) and increased α-fetoprotein(80%).Based on radiological findings and gross specimens,the tumor presented as a solitary lesion or a multifocal space-occupying lesion.The tumor size ranged from 5.0 cm × 3.5 cm × 2.0 cm to 13.8 cm × 9.0 cm × 7.7 cm,and the 0.2-1.1 cm nodules were diffusely distributed within the multifocal tumor.Seven cases were surgically resected,three cases underwent biopsy and the two fetuses were aborted.Histologically,nine cases were classified as typeⅠ and three as type Ⅱ,presenting aggressive morphologic features,immature vessels,active mitosis and necrosis.An inflammatory component,predominantly eosinophilic granulocytes,sometimes obscured the nature of the tumor.Ten patients are alive after a follow-up of 1-9 years.Based on immunohistochemistry,the endothelial cells in all cases were positive for CD31,CD34 and polyclonal factor Ⅷ antigen,whereas the scattered hyperplasia bile ducts were positive for cytokeratin 8 and cytokeratin 18.CONCLUSION:The clinical manifestations of IHE are non-specific.There is no significant correlation between histological type and prognosis.The clinicopathologic features of IHE in Chinese patients may provide a clue to further evidence-based studies. | Zhang Zhang,Hui-Jiao Chen,Wen-Juan Yang,Hong Bu,Bing Wei,Xiao-Yu Long,Jing Fu,Rui Zhang,Yun-Bi Ni,Hong-Ying Zhang,Department of Pathology,West China Hospital,Sichuan University,Guoxuexiang 37,Chengdu 610041,Sichuan Province,China | 2010 | World Journal of Gastroenterology2010，16，36： | 16 |
| 4 | Experimental study of an aircraft fuel tank inerting system显示文摘In this work, a simulated aircraft fuel tank inerting system has been successfully established based on a model tank. Experiments were conducted to investigate the influences of different operating parameters on the inerting effectiveness of the system, including flow rate of the inert gas(nitrogen-enriched air), inert gas concentration, fuel load of the tank and different inerting approaches. The experimental results show that under the same operating conditions, the time span of a complete inerting process decreased as the flow rate of inert gas was increased; the time span using the inert gas with 5% oxygen concentration was much longer than that using pure nitrogen;when the fuel tank was inerted using the ullage washing approach, the time span increased as the fuel load was decreased; the ullage washing approach showed the best inerting performance when the time span of a complete inerting process was the evaluation criterion, but when the decrease of dissolved oxygen concentration in the fuel was also considered to characterize the inerting effectiveness, the approach of ullage washing and fuel scrubbing at the same time was the most effective. | Cai Yan Bu Xueqin Lin Guiping Sun Bing Zeng Yu Li Zixuan | 2015 | Chinese Journal of Aeronautics2015，28，2： | 15 |
| 5 | A novel CFTR mutation found in a Chinese patient with cystic fibrosis显示文摘Background Cystic fibrosis (CF) is rare in Chinese. We investigated the mutations in the gene of cystic fibrosis transmembrane conductance regulator (CFTR) in a Chinese CF patient and reviewed the clinical features, gene mutations in Chinese CF cases. Methods Blood samples were collected from a previously reported CF girl and her parents. The 24 coding exons of CFTR of the proband were amplified and sequenced. Results A Chinese girl of 16 years old was diagnosed as CF at the age of 14. She had recurrent productive cough with bronchiectasis in bilateral upper lobes, parasinusitis and otitis media, but without pancreatic involvement. Her sweat chloride was (108.9 ±3.3) mmol/L. A heterozygous novel missense mutation of 699 C→ A which results in the amino acid change of N189K was identified in exon 5. In addition, a heterozygous 3821-3823 delT mutation in exon 19 was found in CFTR. The mutation 699C→A was inherited from her father, and the 3821-3823delT mutation was from her mother. Twenty patients with CF in Chinese reported from 1974 to 2004 were also reviewed. DelF508 mutation was not found in the nine cases whose CFTR mutations were analyzed. Conclusions The CF proband carries two heterozygous mutations (699C→A and 3821-3823delT) in CFTR. 699C→A mutation is a novel mutation which is not reported previously. Review of reported Chinese cases suggests that the genotype of Chinese CF may be different from those of white cases. More studies are needed to understand the spectra of CFTR and clinical CF features in Chinese. | LI Nan PEI Pei BU Ding-fang HE Bing WANG Guang-fa | 2006 | Chinese Medical Journal2006，，2： | 14 |
| 6 | Characteristics of the HIV/AIDS Epidemic in Women Aged 15-49 Years from 2005 to 2012 in China显示文摘Objective To describe the characteristics of the HIV/AIDS epidemic in women aged 15-49 years in China. Methods HIV/AIDS cases from 2005 to 2012 that fulfilled the inclusion and exclusion criteria were identified on the Chinese HIV/AIDS case reporting system. Descriptive and spatial analyses were performed. Results A total of 103,559 female HIV/AIDS cases were included in our study. Based on the descriptive analysis, between 2005 and 2012, the proportion of heterosexually acquired HIV infection among women(15-49 years) increased rapidly from 35.8% to 87.4%. Approximately 60% of these cases were infected through non-marital heterosexual contact. Among older women(40-49 years), a slightly increasing trend was identified. The spatial analysis detected ‘hot spots' in the Xinjiang, Yunnan, Sichuan, Guangxi, and Chongqing provinces. The epidemic trends in these areas were predominately driven by heterosexual transmission. Conclusion Non-marital heterosexual contact is a very important factor in the HIV/AIDS epidemic in women aged 15-49 years, and the HIV infection rate in older women is increasing. Several epidemic hot spots were detected in northwestern and southwestern China. Efficient interventions are needed to control the spread of HIV/AIDS among women living in these areas. | ZHANG Xia Yan HUANG Tao FENG Yi Bing LI Meng CHEN Fang Fang LI Yin Ge JIN Shan Shan BU Kai WANG Lu | 2015 | Biomedical and Environmental Sciences2015，28，10： | 10 |
| 7 | Clinicopathological, immunohistochemical, and ultrastructural study of 13 cases of melanotic schwannoma显示文摘Background Melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cellswith ultrastructural features of schwann cells.The description of the course of the tumors differs somewhat, but itis generally considered as a benign lesion.We investigated the clinicopathologic features, immunophenotypes,and ultrastructural features of 13 patients with nonpsammomatous melanotic schwannoma (NPMS).Methods Tumor specimens of each patient were sectioned and stained with hematoxylin-eosin, Fontana-Masson, Prussian blue, and periodic acid-Schiff (PAS).Immunohistochemical markers such as S-100, Leu-7,HMB-45, Melan-A, CK, EMA, vimentin, GFAP, laminin, collagenⅣ and MIB-1 were detected with theEnvision immunohistochemical staining method.Four of the cases were observed by electron microscopy.Results Of the 13 patients, 8 were male and 5 female, aged from 11 to 92 years (mean, 38.6 years).Thetumor sites included the spinal nerve root (5 patients), cranial nerve (1), greater omentum (1), subcutaneoustissue (3), mesentery (1), bone (1) and mediastinum(1).Eleven patients were followed up for over2 years,with a mean of 5.9 years.One patient (9.1%) with a primary tumor in the greater omentum developed anotherprimary tumor of the same type in the subcutaneous tissue of the abdominal wall after the first operation.Localrecurrence of the tumor was seen in2 patients (18.2%).One patient (9.1%) showed the local recurrence andmetastasis.Seven patients (63.6%) showed no evidence of the recurrence or metastasis.Grossly, all tumorswere well-circumscribed and the gross findings were suggestive of melanin-containing tumors.The tumor wascomposed of spindled and epithelioid cells with abundant intracytoplasmic melanin pigments.Nuclei were roundand contained delicate, evenly distributed chromatins as well as small, distinct nucleoli.In some areas, thenucleoli were large and prominent.Rare mitoses were seen in mostlesions exceptthe larger omentumlesion.Thepigment was shown to be positive for the Fontana-Masson and negative for Prussian blue and PAS.Immunohistochemical staining for S-100, Leu-7, HMB-45, Melan-A, and vimentin were strongly positive.Linear immunoreactions of both laminin and collagenⅣ was detected in all patients.Ultrastructurally, numerouselongated tumor-cell processes, duplicated basement membrane and melanosomes were observed in alldevelopmental stages.Conclusions Histologically, melanotic schwannoma is a rare variant of schwannoma composed of melanin-producing cells with ultrastructural features ofschwann cells.Distinguishing between this tumor andmalignant melanoma is of paramount importance inplanning of management. Immunohistochemically,combined use of laminin and collagenⅣ is valuablein distinguishing melanotic schwannoma frommalignant melanoma. Wide local resection andadditional radiotherapy should be advocated.Furtherstudies including cytogenetic or molecular biology arestill required to better delineate melanoticschwannoma from malignant melanoma. Appropriate long-term follow-up is needed for all melanoticschwannomas. | ZHANG Hong-ying YANG Guang-hua CHEN Hui-jiao WEI Bing KE Qi GUO Hua YE Lü BU Hong YANG Ke ZHANG Yuan-heng | 2005 | Chinese Medical Journal2005，，17： | 9 |
| 8 | Clinicopathologic features of pleomorphic hyalinizing angiectatic tumor of soft parts显示文摘软部分的背景 Pleomorphic hyalinizing angiectatic 肿瘤(PHAT ) 是一个稀罕软织物肿瘤,它是通常考虑的低档。把肿瘤与另外的软织物损害区分开来,我们在 9 个 cases.Methods PHAT 标本分析了 clinicopathologic 和 ultrastructural 特征, immunophenotypes,和 PHAT 的流动 cytometric DNA ploidy 从 1990 ~ 2004 与 PHAT 从 9 个病人被收集。每个标本被切成片并且与 hematoxylin 曙红, phosphotungstic acid-hematoxylin,普鲁士的蓝色,和马森染色了三色分别地。为 vimentin 的 Immunohistochemical 污点, S-100 蛋白质, CD34, CD31, CD99, VEGF, desmin, CD117, -SMA,and MIB-1 与 Envision 系统被执行。流动 cytometry 在四个标本,其二个被电子 microscopy.Results 在 9 个盒子中观察,被使用 PHAT 在 2 个病人,发生在更低的极限在 2 腹股沟,在 1 的腰,在 1 的前臂,在 1 的屁股,在 1 的脚,并且在 1 的胸墙。在表面的下的纸巾介绍的所有损害。后续数据在 7 个病人,(28.6%) 2 在主要治疗以后在之中有复发是可得到的。用显微镜,典型 PHAT 被锭子或 pleomorphic 房间和薄墙的 hyalinized cstatic 容器的簇的像表的增长描绘。在肿瘤, hemosiderin 沉重的锭子房间,众多的小单个容器,和 myxoid 的一些区域,细胞外的矩阵能被识别,显示“不正常的 PHAT ”。有丝分裂的数字在所有 cases.In 是稀罕的 9 个病人(55.6%) 中的 5 个,肿瘤是典型 PHAT;并且在其它 4 (44.4%) ,典型、不正常的 PHAT 共存了。Immunohistochemically,肿瘤的房间为 vimentin, CD34, CD99,和 VEGF 是积极的,但是为 S-100 蛋白质, desmin, SMA,和 CD31 否定。在所有盒子中,肿瘤的房间的 MIB-1 proliferative 活动比 2% 低。Ultrastructural 分析没揭示特定的区别的任何证据。Aneuploidy 没被流动 cytometry.Conclusions 组织学地检测,典型 PHAT 被与 angiectatic vasculature 联系的锭子和 pleomorphic 房间描绘。肿瘤的房间经常表示 vimentin 和 CD34,并且可能为 CD99 积极并且 VEGF.Ultrastructurally,肿瘤通常没有特定的区别。低 MIB-1 索引和在 PHAT 的 aneuploidy 的缺席显示非恶意。然而,因为它的好攻击的行为,我们把肿瘤看作一个边线瘤,并且为疾病的治疗与没有肿瘤的边缘建议宽本地切除术。 | KE Qi Erbolat ZHANG Hong-ying BU Hong LI Sheng SHI Dan-ni YANG Guang-hua CHEN Hui-jiao WEI Bing | 2007 | Chinese Medical Journal2007，，10： | 9 |
| 9 | A comparison of atmospheric CO_2 concentration GOSAT-based observations and model simulations显示文摘Satellite observations of atmospheric CO2 are able to truly capture the variation of global and regional CO2 concentration.The model simulations based on atmospheric transport models can also assess variations of atmospheric CO2 concentrations in a continuous space and time,which is one of approaches for qualitatively and quantitatively studying the atmospheric transport mechanism and spatio-temporal variation of atmospheric CO2 in a global scale.Satellite observations and model simulations of CO2 offer us two different approaches to understand the atmospheric CO2.However,the difference between them has not been comprehensively compared and assessed for revealing the global and regional features of atmospheric CO2.In this study,we compared and assessed the spatio-temporal variation of atmospheric CO2 using two datasets of the column-averaged dry air mole fractions of atmospheric CO2(XCO2)in a year from June 2009 to May 2010,respectively from GOSAT retrievals(V02.xx)and from Goddard Earth Observing System-Chemistry(GEOS-Chem),which is a global 3-D chemistry transport model.In addition to the global comparison,we further compared and analyzed the difference of CO2 between the China land region and the United States(US)land region from two datasets,and demonstrated the reasonability and uncertainty of satellite observations and model simulations.The results show that the XCO2 retrieved from GOSAT is globally lower than GEOS-Chem model simulation by 2 ppm on average,which is close to the validation conclusion for GOSAT by ground measures.This difference of XCO2 between the two datasets,however,changes with the different regions.In China land region,the difference is large,from 0.6 to 5.6 ppm,whereas it is 1.6 to 3.7 ppm in the global land region and 1.4 to 2.7 ppm in the US land region.The goodness of fit test between the two datasets is 0.81 in the US land region,which is higher than that in the global land region(0.67)and China land region(0.68).The analysis results further indicate that the inconsistency of CO2concentration between satellite observations and model simulations in China is larger than that in the US and the globe.This inconsistency is related to the GOSAT retrieval error of CO2 caused by the interference among input parameters of satellite retrieval algorithm,and the uncertainty of driving parameters in GEOS-Chem model. | LEI LiPing GUAN XianHua ZENG ZhaoCheng ZHANG Bing RU Fei BU Ran | 2014 | Science China Earth Sciences2014，57，6： | 6 |
| 10 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 11 | Reproducibility of the Nottingham modification of the Scarff- Bloom-Richardson histological grading system and the complementary value of Ki-67 to this system显示文摘背景为侵略乳癌(IBC ) 的组织学的分级系统由世界健康组织采用了的 Scarff-Bloom-Richardson (NSBR ) 的诺丁汉修正的重制度() 以前没在中国医院里被学习。增长标记, Ki-67,广泛地在检测 IBC 被使用了。这研究的目的是在中国病理学家和 Ki-67 独立地带给 100 个 IBC 盒子到四个一般病理学家分级的这 system.Methods 的互补价值之中估计 NSBR 系统的重制度,它被专家以前在胸病理分级。在四个一般病理学家之中的 interobserver 重制度和在他们和专家中的每之间的 pairwise 重制度被估计。把索引(Ki-67LI ) 标记的 Ki-67 被 immunohistochemistry 决定,并且它与组织学的等级和幸存的关联是关于 interobserver 重制度的 determined.Results,分级的 NSBR 是相当可再现的(kappa=0.34 ) ;至于分级的 NSBR 的部件,同意为小管形成(kappa=0.46 ) 是最好的,为有丝分裂的计数(kappa=0.28 ) 为原子多形性(kappa=0.42 ) 中间、最差。以 pairwise 重制度,同意对公正与分级的 NSBR (kappa=0.30-0.69 ) 和原子多形性(kappa=0.28-0.69 ) 实质,对中等到为小管形成(kappa=0.51-0.78 ) 实质、细微实质因为有丝分裂的计数(kappa=0.19-0.71 ).There 是为等级的典型 Ki-67LI 范围 1,2 和 3 个肿瘤。Univariate 分析证明 Ki-67 能把等级 2 病人划分成二不同预示的亚群。有否定淋巴节点的等级 2 病人的 Multivariate 分析证明 Ki-67 是为全面 survival.Conclusions 的一个独立预言者由一般病理学家分级的重制度能被提高。在胸病理的专门化为为 IBC 的精确分级和治疗是必要的。与证明预示的意义, Ki-67 把互补价值加到 NSBR 系统。 | ZHANG Rui CHEN Hui-jiao WEI Bing ZHANG Hong-ying PANG Zong-guo ZHU Hong ZHANG Zhang FU Jing BU Hong | 2010 | Chinese Medical Journal2010，，15： | 3 |
| 12 | Investment Environment Assessment and Strategic Policy for Subjects of Federation in Russia显示文摘Russia is the largest neighboring country of China. Between the two countries, the resources and industry are complemented, the political mutual trust is at a high level, and trade cooperation has a broad prospect. Choosing the best regions and the best industries to strengthen investment in Russia has a major strategic significance in promoting ‘the Belt and Road Initiative’ and China-Mongolia-Russia Economic Corridor Construction. However, the related researches are extremely limited. The investment environment is unclear, and the investment risk is unknown, which seriously restrict the investment in Russia and the trade cooperation with Russia. Our research team carried out scientific expedition, government visits and scientific research cooperation in Russia for several years, and obtained a great number of first-hand valuable data. According to the analysis on the data and Russian regional policies, this study constructed an investment environment evaluation model(ESI-PRA model), scientific assessed the investment environment for 83 subjects of federation in Russia, in terms of economic, social, infrastructure, policy, resource and accessibility, classified 4 types of investment regions, chose 3 investment priority regions, revealed the investment priority industries, demonstrated the main investment risks, and proposed the strategic policies. The research results provide direct scientific and technological support for strategic decisions, such as investment in Russia, bilateral economic and trade cooperation, and overseas layout of Chinese-funded enterprises. Moreover, it has an important practical and strategic significance for improving overseas geo-strategic interests of China and ensuring the construction of China-Mongolia-Russia Economic Corridor. | LI Fujia LIU Qian DONG Suocheng CHENG Hao LI Yu YANG Yang TSYDYPOV Bair BILGAEVAlexey AYURZHANAEV Alexander BU Xiaoyan XIA Bing | 2019 | Chinese Geographical Science2019，29，5： | 3 |
| 13 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 14 | Nickel(Ⅱ) a-Diimine Catalysts with Carboxyl Groups for Ethylene Oligomerization and Polymerization显示文摘A series of nickel(II) ?-diimine complexes with strong electron-withdrawing carboxyl groups, having reactive hydrogen atoms, were prepared and used as precatalysts for ethylene oligomerization and/or polymerization. The influence of metal halides and ligand structure on the catalytic activity and properties of products was investigated. The results showed that nickel bromide was much more active than nickel chloride, and the substituents at the ortho-position of aryl ring had large influence on the properties of products. Therefore, the products ranging from liquid oligomers to polymers could be readily obtained by the variation of the substituents on the ligands and reaction conditions. | Bing Liu Meng-zhe Fang 介素云 Zhi-yang Bu Bo-Geng Li | 2016 | Chinese Journal of Polymer Science2016，34，2： | 2 |
| 15 | A durable 4-1BB-based CD19 CAR-T cell for treatment of relapsed or refractory non-Hodgkin lymphoma显示文摘Objective:Previous studies reported that 4-1BB-based CD19 chimeric antigen receptor(CAR)-T cells were more beneficial for the clinical outcomes than CD28-based CAR-T cells,especially the lower incidence rate of severe adverse events.However,the median progression-free survival(mPFS)of 4-1BB-based product Kymriah was shorter than that of CD28-based Yescarta(2.9 months vs.5.9 months),suggesting that Kymriah was limited in the long-term efficacy.Thus,a safe and durable 4-1BB-based CD19 CAR-T needs to be developed.Methods:We designed a CD19-targeted CAR-T(named as IM19)which consisted of an FMC63 scFv,4-1BB and CD3ζintracellular domain and was manufactured into a memory T-enriched formulation.A phase I/II clinical trial was launched to evaluate the clinical outcomes of IM19 in relapsed or refractory(r/r)B cell non-Hodgkin lymphoma(B-NHL).Dose-escalation investigation(at a dose of 5×10^(5)/kg,1×10^(6)/kg and 3×106/kg)was performed in 22 r/r B-NHL patients.All patients received a single infusion of IM19 after 3-day conditional regimen.Results:At month 3,the overall response rate(ORR)was 59.1%,the complete response rate(CRR)was 50.0%.The mPFS was 6 months and the 1-year overall survival rate was 77.8%.Cytokine release syndrome(CRS)occurred in 13 patients(59.1%),with 54.5%of grade 1−2 CRS.Only one patient(4.5%)experienced grade 3 CRS and grade 3 neurotoxicity.Conclusions:These results demonstrated the safety and durable efficacy of a 4-1BB-based CD19 CAR-T,IM19,which is promising for further development and clinical investigation. | Zhitao Ying Ting He Shanzhao Jin Xiaopei Wang Wen Zheng Ningjing Lin Meifeng Tu Yan Xie Lingyan Ping Weiping Liu Lijuan Deng Yanping Ding Xuelian Hu Bing Bu Xin’an Lu Yuqin Song Jun Zhu | 2022 | Chinese Journal of Cancer Research2022，34，1： | 2 |
| 16 | Predictive functional control for communication-based train control (CBTC) systems 显示文摘 | BU Bing YANG Jing-wei WEN Shu-hua LI Zhu | 2013 | International journal of Advanced Robotic Systems2013，10，： | 1 |
| 17 | Expandingdomain sentiment lexicon through double propagation显示文摘 | Qiu Guang Liu Bing Bu Jiajun | 2009 | Computational Linguistics2009，37，1： | 1 |
| 18 | Prognostic significance of tumor grading and staging in mammary carcinomas with neuroendocrine differentiation显示文摘 | Zhen Tian Bing Wei Feng Tang Wei Wei Michael Z. Gilcrease Lei Huo Constance T. Albarracin Erika Resetkova Lavinia Middleton Aysegul Sahin Yan Xing Kelly K. Hunt Jieqing Chen Hong Bu Asif Rashid Susan C. Abraham Yun Wu | 2011 | Human Pathology2011，，8： | 1 |
| 19 | Estimating the diffusion models of crisis information in micro blog显示文摘 | Wei Jiuchang Bu Bing Liang Liang | 2012 | Joumal of Informet- tics2012，6，4： | 1 |
| 20 | Synthesis and property of imidazolium oxidative-thermoregulated ionic liquids显示文摘A series of novel imidazolium oxidative-thermoregulated bifunctional ionic liquids(ILs) have been synthesized by introducing the thermoregulated structural unit into imidazolium cation and using heteropolyanion as the anion of ILs. The structures of these new type of taskspecific ionic liquids(TSILs) are characterized by FT-IR and1 H NMR. The thermostability of ILs is analyzed by thermogravimetry. The thermoregulated properties of ILs in aqueous and organic solvents are mainly investigated.These ILs have the corresponding cloud points(CPs) in aqueous. The effects of IL concentration, polymerization degree, inorganic additives and organic additives on the CP are studied. IL/DMF/n-heptane or n-octane biphasic system has the corresponding critical solution temperature(CST),and has the feature of ‘‘homogeneous at high temperature,heterogeneous at low temperature''. The effects of IL dosage and polymerization degree on the CST are given.IL/DMF/n-octane thermoregulated biphasic system has been successfully applied for catalytic oxidative desulfurization of model fuels. This study opens up a new way for catalytic oxidation to achieve an integration of homogeneous catalysis and heterogeneous separation. | Fengli Yu Chunyu Liu Congxia Xie Bing Yuan Tongan Bu Shitao Yu | 2014 | Chinese Science Bulletin2014，59，34： | 1 |
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