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| 1 | 人参皂苷Rg1对糖尿病大鼠心肌氧化应激及细胞凋亡的影响(英文)显示文摘目的:探讨人参皂苷Rg1对高血糖所致心肌损害的保护作用及其机制。创新点:使用糖尿病大鼠为实验对象,探讨三种浓度的人参皂苷Rg1对糖尿病心肌损伤的保护作用及其机制,检测其是否具有浓度依赖性。方法:将60只Wistar大鼠随机分组,其中空白对照组10只,另50只给予高脂高糖饲养,4周后腹腔注射40 mg/kg链脲佐菌素(STZ)。成功制备糖尿病大鼠模型40只,再随机分为糖尿病模型组,糖尿病大鼠+低剂量人参皂苷Rg1(10 mg/(kg·d)),糖尿病大鼠+中剂量人参皂苷Rg1(15 mg/(kg·d)),糖尿病大鼠+高剂量人参皂苷Rg1(20 mg/(kg·d))。12周后处死大鼠,取血测定空腹血糖、总胆固醇(TC)、甘油三酯(TG)、心肌酶及氧化应激水平,留取心肌组织使用透射电镜观察心肌细胞超微结构改变,应用TUNEL法检测心肌细胞凋亡,免疫组化检测细胞凋亡相关蛋白半胱氨酸天冬氨酸蛋白酶3(CASP3)和Bcl-x L的表达。结论:人参皂苷Rg1对糖尿病大鼠糖脂代谢无明显影响,人参皂苷Rg1可降低糖尿病大鼠血清肌钙蛋白(c Tn I)和肌酸激酶同工酶(CK-MB)水平,改善心肌细胞超微结构,减少心肌细胞凋亡,降低大鼠血清和心肌组织中丙二醛(MDA)含量,提高超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH)水平,降低凋亡蛋白CASP3的表达,同时提高Bcl-x L蛋白表达。总之,人参皂苷Rg1能显著保护糖尿病大鼠心肌损伤,其机制可能与其抗氧化及抗细胞凋亡作用有关。 | Hai-tao YU Juan ZHEN Bo PANG Jin-ning GU Sui-sheng WU | 2015 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2015，16，5： | 23 |
| 2 | A Theoretical Framework and Methodology for Urban Activity Spatial Structure in E-society: Empirical Evidence for Nanjing City, China显示文摘The existing researches on the influence of information and communication technology(ICT) are mainly focused on human activity, whilst with few efforts on urban space. In the e-society, the widespread adoption of ICT devices not only affects almost every aspect of people′s daily life and thereby reshapes the spatial development of regions and cities, but also generates a large amount of real-time activity data with location information. These georeferenced data, however, have relatively recently attracted attention from geographers. Adapted from Lynch′s framework based on people′s perceptions, this paper proposes a framework of urban spatial structure based on people′s actual activity, including five elements, namely activity path, activity node, central activity zone(CAZ), activity district, and activity edge. In the empirical study, by using one week′s check-in tweets(from February 25 to March 3 in 2013) collected in Nanjing City, the five elements are recognized and analyzed. Through the comparison between our results and urban spatial structure based on population(and land use), we argue that ICT uses: 1) lead to polarize, rather than to smooth, the urban structural hierarchy, due to the dual role of distance; 2) enable a partial decoupling of activity and activity space node, which challenges our conventional understanding of the role of home and the utility of travel; 3) blur the boundaries of activity districts and hence may play a positive role in enriching districts′ functions, which should not be overlooked in the current urban transformation in China. | WANG Bo ZHEN Feng WEI Zongcai GUO Shu CHEN Tingting | 2015 | Chinese Geographical Science2015，25，6： | 17 |
| 3 | Laboratory investigation on the properties of asphalt mixtures modified with double-adding admixtures and sensitivity analysis显示文摘In order to improve the high temperature stability and low temperature cracking resistance of asphalt mixtures,two varieties of admixtures(anti-rutting agent and lignin fiber) were selected and then combined.This is called double-mixture technology.A series of tests about pavement performance of base asphalt mixtures and asphalt mixtures with admixture of anti-rutting agent or lignin fiber were conducted.Meanwhile sensitivity analyses were used to study the influence of three factors(i.e.,asphalt grade,aggregate type and gradation) on the high and low temperature performance and water stability of said asphalt mixtures.Test results indicated that the dynamic stability,residual stability,TSR and low temperature failure strain of asphalt mixtures have increased significantly with the additions of 0.40% anti-rutting agent and 0.36% lignin fiber.These results show that the high and low temperature and water stabilities of asphalt mixtures improve obviously.This supports the beneficial comprehensive effect of the double admixture.The problem of improving the asphalt mixtures performance with a single admixture is solved,in addition to also improving other pavement performance.Based on the sensitivity analysis,the most influential factors of dynamic stability,low temperature failure strain and TSR are the gradation,followed by asphalt grade and aggregate type. | Zhen Fu Yanni Dang Bo Guo Yue Huang | 2016 | Journal of Traffic and Transportation Engineering(English Edition)2016，3，5： | 17 |
| 4 | COVID-19 Outbreak Caused by Contaminated Packaging of Imported Cold-Chain Products—Liaoning Province,China,July 2020显示文摘Summary What is known about this topic?Few major outbreaks of coronavirus disease 2019(COVID-19)have occurred in China after major nonpharmaceutical interventions and vaccines have been deployed and implemented.However,sporadic outbreaks that had high possibility to be linked to cold chain products were reported in several cities of China..What is added by this report?In July 2020,a COVID-19 outbreak occurred in Dalian,China.The investigations of this outbreak strongly suggested that the infection source was from COVID-19 virus-contaminated packaging of frozen seafood during inbound unloading personnel contact.What are the implications for public health practice?Virus contaminated paper surfaces could maintain infectivity for at least 17–24 days at-25℃.Exposure to COVID-19 virus-contaminated surfaces is a potential route for introducing the virus to a susceptible population.Countries with no domestic transmission of COVID-19 should consider introducing prevention strategies for both inbound travellers and imported goods.Several measures to prevent the introduction of the virus via cold-chain goods can be implemented. | Huilai Ma1 Jianqun Zhang Ji Wang Ying Qin Cao Chen Yang Song Liang Wang Jun Meng Lingling Mao Fengqin Li Ning Li Jian Cai Yong Zhang Dayan Wang Yunting Xia Hong Wang Shaofeng Jiang Xiang Zhao Peihua Niu Wenjie Tan Tao Ma Yecheng Yao Naiying Mao Zhen Zhu Tianjiao Ji Qian Yang Baoying Huang Li Zhao Jianxing Yu Li Bai Shuangli Zhu Dongyan Wang Yan Zhang Yingwei Sun Mingchun Luan Yanhai Wang Haibo Sun Shihong Yang Zhijian Bo Xiang Ren Zhongjie Li George Fu Gao Wei Yao Wenqing Yao Zijian Feng Wenbo Xu | 2021 | China CDC weekly2021，3，21： | 16 |
| 5 | Effects of Rhein lysinate on H202-induced cellular senescence of human umbilical vascular endothelial cells显示文摘 | Ya-jun LIN Yong-zhan ZHEN Jie WEI Bo LIU Zong-yuan YU Gang HU | 2011 | Acta Pharmacologica Sinica2011，32，10： | 16 |
| 6 | Antioxidant and Anti-inflammatory Capacity of Ferulic Acid Released from Wheat Bran by Solid-state Fermentation of Aspergillus niger显示文摘Objective A strain of Aspergillus niger(A. niger), capable of releasing bound phenolic acids from wheat bran, was isolated. This strain was identified by gene sequence identification. The antioxidant and anti-inflammatory capacity of ferulic acid released from wheat bran by this A. niger strain(FA-WB) were evaluated. Methods Molecular identification techniques based on PCR analysis of specific genomic sequences were conducted; antioxidant ability was examined using oxygen radical absorbance capacity(ORAC), cellular antioxidant activity(CAA) assays, and erythrocyte hemolysis assays. RAW264.7 cells were used as a model to detect anti-inflammatory activity. Results The filamentous fungal isolate was identified to be A. niger. ORAC and CAA assay showed that FA-WB had better antioxidant activity than that of the ferulic acid standard. The erythrocyte hemolysis assay results suggested that FA-WB could attenuate AAPH-induced oxidative stress through inhibition of reactive oxy gen species(ROS) generation. FA-WB could significantly restore the AAPH-induced increase in intracellular antioxidant enzyme activities to normal levels as well as inhibit the intracellular malondialdehyde formation. TNF-?, IL-6, and NO levels indicated that FA-WB can inhibit the inflammation induced by lipopolysaccharide(LPS). Conclusion Ferulic acid released from wheat bran by a new strain of A. niger had good anti-inflammatory activity and better antioxidant ability than standard ferulic acid. | YIN Zhi Na WU Wen Jia SUN Chong Zhen LIU Hui Fan CHEN Wen Bo ZHAN Qi Ping LEI Zhuo Gui XIN Xuan MA Juan Juan YAO Kun MIN Tian ZHANG Meng Meng WU Hui | 2019 | Biomedical and Environmental Sciences2019，32，1： | 14 |
| 7 | Expressions of chromogranin A and cathepsin D in human primary hepatocellular carcinoma显示文摘AIM To determine the expression and clinicalsignificance of chromogranin A and cathepsin Din hepatocellular carcinoma(HCC).METHODS Double immunofluorescence stain-ing techniques combined with laser confocalscanning microscopy(LSCM)was used toinvestigate chromogranin A and cathepsin Dexpressions in 85 HCC patients.RESULTS Cathepsin D was expressed in :3normal liver tissues,while in HCC the stainingshowed regional variation and the fraction ofstrongly stained cells increased as the tumorsbecame less differentiated and usually clinicallymore malignant.Cells which showed strongpositivity for cathepsin D were present in 71/85(83.5%)cases.Strong expression of cathepsinD in cancer cells was related tohistopathological features.They were morecommon in grade 3-4(26/28,92.9%)and grade2(46/53,86.8%)tumors than in grade 1 tumors(1/4,25.0%)(P<0.01).No significantcorrelation was found between age andcathepsin D expression.In patients with positivecathepsin D reaction,the mean age was 52.1±2.8 years(range 32-68 years)and in the groupwith negative reaction,the mean age was 51.3±4.5 years(range 28-71 years).No obvious relationship was observed between CgAexpression in cancer cells and thehistopathological features.The CgA positiverate was 75.0%(3/4)in grade 1,71.7%(38/53)in grade 2,and 71.4%(20/28)in grade 3-4(P>0.05)tumors.The coexpression of CgA andcathepsin D was found by double labeledimmunofluorescence staining techniques.Theprocessing of cathepsin D was disturbed in HCCcells and accumulated in the cells.Cathepsin Dhad proteolytic activity and autocrine mitogeniceffect,suggesting their functions in invasion.These findings demonstrated that the expressionof cathepsin D in HCC had prognostic value.CONCLUSION Chromogranin A and cathepsin Dare expressed in a high proportion of HCC andthe existence of cathepsin D in HCC might berelated to processing of CgA.This is clearly asubject for further studies because of itspotential clinical applications. | Xiao Feng Huang Chun Mei Wang Xiao Wen Dai Zhen Jiang Li Bo Rong Pan Li Bin Yu Bin Qian Li Fang | 2000 | World Journal of Gastroenterology2000，6，5： | 12 |
| 8 | The Efficacy of High-Intensity Focused Ultrasound (HIFU) in Advanced Pancreatic Cancer显示文摘OBJECTIVE To observe the efficacy of high-intensity focused ultrasound (HIFU) in the treatment of late-stage pancreatic cancer. METHODS Sixteen patients with advanced pancreatic cancer received HIFU therapy.Evaluation of efficacy was made on the basis of changes in clinical symptoms and variations in the tumor echo and size. RESULTS Clinical symptoms such as pain were significantly alleviated,echo of the tumor was enhanced with B-US and the quality of life such as eating,sleeping and mental status was markedly improved;no serious complications were observed. CONCLUSION The use of HIFU in the treatment of advanced pancreatic cancer is feasible and safe.It is effective in killing the carcinoma cells and alleviating pain.This technique may offer non-invasive therapy for the treatment of patients with late-stage pancreatic cancer. | Bo Xie Jiajun Ling Weiming Zhang Xueqin Huang Jihua Zhen Yanzhe Huang | 2008 | Chinese Journal of Clinical Oncology2008，5，3： | 12 |
| 9 | Design and performance analysis of orthogonal coding signal in MIMO-SAR显示文摘Multi-input multi-output (MIMO) radar which has evident advantages in many applications is a new radar system.Applying the MIMO technique to the earth observing synthetic aperture radar (SAR) system offers effective ways for the improvement of high resolution and wide swath imaging and ground moving target indication (GMTI) systems.Designing the optimal orthogonal waveform is a crucial problem in the research on MIMO radar.First,the index definition of synthetic integrated side-lobe level ratio (ISLR) is proposed by focusing on the SAR application and considering the cross-correlation energy influences between orthogonal coding signals with the same frequency band.Second,it is theoretically demonstrated that the performance of synthetic ISLR of orthogonal coding signals with the same frequency band cannot meet the demands of SAR imaging,which has been proved by one-dimensional numerical simulation. Third,it has been shown through numerical simulation that the performance of synthetic ISLR of orthogonal coding signals still cannot be improved by dealing with the mismatched filtering.Finally,a set of orthogonal phase coding signals are designed for multiple MIMO-SAR antennas.The conclusions are verified through MIMO-SAR imaging and InSAR simulation experiments. | ZOU Bo DONG Zhen LIANG DianNong | 2011 | Science China(Information Sciences)2011，54，8： | 11 |
| 10 | Interface issues of lithium metal anode for high-energy batteries: Challenges, strategies, and perspectives显示文摘Lithium(Li)metal is considered as one of the most promising anode materials for next-generation high-energy-density storage systems.However,the practical application of Li metal anode is hindered by interfacial instability and air instability due to the highly reactivity of Li metal.Unstable interface in Li metal batteries(LMBs)directly dictates Li dendrite growth,“dead Li”and low Coulombic efficiency,resulting in inferior electrochemical performance of LMBs and even safety issues.In addition,its sensitivity to ambient air leads to the severe corrosion of Li metal anode,high requirements of production and storage,and increased manufacturing cost.Plenty of efforts in recent years have overcome many bottlenecks in these fields and hastened the practical applications of high-energy-density LMBs.In this review,we focus on emerging methods of these two aspects to fulfill a stable and low cost electrode.In this perspective,design artificial solid electrolyte interphase(SEI)layers,construct three-dimensional conductive current collectors,optimize electrolytes,employ solid-state electrolytes,and modify separators are summarized to be propitious to ameliorate interfacial stability.Meanwhile,ex situ/in situ formed protective layers are highlighted in favor of heightening air stability.Finally,several possible directions for the future research on advanced Li metal anode are addressed. | Yiyao Han Bo Liu Zhen Xiao Wenkui Zhang Xiuli Wang Guoxiang Pan Yang Xia Xinhui Xia Jiangping Tu | 2021 | InfoMat2021，3，2： | 11 |
| 11 | Enhancement of acellular cartilage matrix scaffold by Wharton’s jelly mesenchymal stem cell-derived exosomes to promote osteochondral regeneration显示文摘Articular cartilage defect repair is a problem that has long plagued clinicians.Although mesenchymal stem cells(MSCs)have the potential to regenerate articular cartilage,they also have many limitations.Recent studies have found that MSC-derived exosomes(MSC-Exos)play an important role in tissue regeneration.The purpose of this study was to verify whether MSC-Exos can enhance the reparative effect of the acellular cartilage extracellular matrix(ACECM)scaffold and to explore the underlying mechanism.The results of in vitro experiments show that human umbilical cord Wharton’s jelly MSC-Exos(hWJMSC-Exos)can promote the migration and proliferation of bone marrow-derived MSCs(BMSCs)and the proliferation of chondrocytes.We also found that hWJMSC-Exos can promote the polarization of macrophages toward the M2 phenotype.The results of a rabbit knee osteochondral defect repair model confirmed that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration.We demonstrated that hWJMSC-Exos can regulate the microenvironment of the articular cavity using a rat knee joint osteochondral defect model.This effect was mainly manifested in promoting the polarization of macrophages toward the M2 phenotype and inhibiting the inflammatory response,which may be a promoting factor for osteochondral regeneration.In addition,microRNA(miRNA)sequencing confirmed that hWJMSC-Exos contain many miRNAs that can promote the regeneration of hyaline cartilage.We further clarified the role of hWJMSC-Exos in osteochondral regeneration through target gene prediction and pathway enrichment analysis.In summary,this study confirms that hWJMSC-Exos can enhance the effect of the ACECM scaffold and promote osteochondral regeneration. | Shuangpeng Jiang Guangzhao Tian Zhen Yang Xiang Gao Fuxin Wang Juntan Li Zhuang Tian Bo Huang Fu Wei Xinyu Sang Liuqi Shao Jian Zhou Zhenyong Wang Shuyun Liu Xiang Sui Quanyi Guo Weimin Guo Xu Li | 2021 | Bioactive Materials2021，6，9： | 11 |
| 12 | A de novo Genome of a Chinese Radish Cultivar显示文摘Here, we report a high-quality draft genome of a Chinese radish(Raphanus sativus) cultivar. This draft contains 387.73 Mb of assembled scaffolds, 83.93% of the scaffolds were anchored onto nine pseudochromosomes and 95.09% of 43 240 protein-coding genes were functionally annotated. 184.75 Mb(47.65%) of repeat sequences was identified in the assembled genome. By comparative analyses of the radish genome against 10 other plant genomes, 2 275 genes in 780 gene families were found unique to R. sativus. This genome is a good reference for genomic study and of great value for genetic improvement of radish. | ZHANG Xiaohui YUE Zhen MEI Shiyong QIU Yang YANG Xinhua CHEN Xiaohua CHENG Feng WU Zhangyan SUN Yuyan JING Yi LIU Bo SHEN Di WANG Haiping CUI Na DUAN Yundan WU Jian WANG Jinglei GAN Caixia WANG Jun WANG Xiaowu LI Xixiang | 2015 | Horticultural Plant Journal2015，1，3： | 10 |
| 13 | Enhancement of strength and electrical conductivity for a dilute Al-Sc-Zr alloy via heat treatments and cold drawing显示文摘Developing heat-resistant conductors with high strength and high electrical conductivity is a key issue in the electrical conductor industries, as the ever-increasing power transmission poses higher requirement on the thermal stability of electrical conductor wires. Dilute Al-Sc-Zr alloys are considered as promising candidates due to the excellent heat resistance and high electrical conductivity, but the low strength always limits their application on electrical wires. Yet, few efforts on process design have been made in dilute Al-Sc-Zr alloys to enhance the strength. Here, various kinds of processing paths via combination of cold drawing, ageing and/or annealing were conducted to improve the strength and electrical conductivity of a dilute Al-Sc-Zr alloy. Results show that enhanced strength and electrical conductivity were obtained after cold drawing + ageing or pre-ageing + cold drawing + annealing treatments processes.Optimal properties(194 MPa in ultimate tensile strength and 61% IACS in electrical conductivity) were obtained through cold drawing followed by ageing. Microstructure evolution which affects strength and electrical conductivity was systematically investigated using TEM and 3 DAP. The enhanced strength was mainly attributed to the suitable interactions between strain strengthening and precipitation strengthening. The enhancement in electrical conductivity was caused by precipitation of solute atoms and recovery of defects. These results provide foundations for the processing design of Al-Sc-Zr conducting wires with good properties and push forward their potential application in heat resistant conductor industries. | Li Liu Jian-Tang Jiang Bo Zhang Wen-Zhu Shao Liang Zhen | 2019 | Journal of Materials Science & Technology2019，35，6： | 9 |
| 14 | How does the motor relearning program improve neurological function of brain ischemia monkeys?显示文摘The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia. | Yong Yin Zhen Gu Lei Pan Lu Gan Dongdong Qin Bo Yang Jin Guo Xintian Hu Tinghua Wang Zhongtang Feng | 2013 | Neural Regeneration Research2013，8，16： | 9 |
| 15 | Involvement of the Mitochondrion-dependent and the Endoplasmic Reticulum Stress-signaling Pathways in Isoliquiritigenin-induced Apoptosis of HeLa Cell显示文摘Objective Isoliquiritigenin(ISL),a licorice chalconoid,is considered to be a bioactive agent with chemopreventive potential.This study investigates the mechanisms involved in ISL-induced apoptosis in human cervical carcinoma HeLa cells.Methods Cell viability was evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide(MTT)assay.Apoptosis was determined by flow cytometry using an Annexin V-FITC Apoptosis Detection Kit.The intracellular ROS levels were assessed using a 2,7-dichlorofluorescein probe assay.The mitochondrial membrane potential was measured with the dual-emission potential-sensitive probe 5,5',6,6'-tetra-chloro-1,1',3,3'-tetraethyl-imidacarbocyanine iodide(JC-1).The degradation of poly-ADP-ribose polymerase(PARP)protein,the phosphorylation of PKR-like ER kinase(PERK),the phosphorylation of the α-subunit of eukaryotic initiation factor 2(eIF2α),the expression of the 78 kD glucose-regulated protein(GRP 78),and the activation of caspase-12 were analyzed via western blot analysis.Results ISL significantly inhibited the proliferation,the increase in ROS levels and apoptotic rates of HeLa cells in a concentration-dependent manner.Moreover,ISL induced mitochondrial dysfunction,caspase activation,and PARP cleavage,which displayed features of mitochondria dependent on apoptotic signals.Besides,exposure of HeLa cells to ISL triggered endoplasmic reticulum(ER)stress,as indicated by the increase in p-eIF2α and GRP78 expression,ER stress-dependent apoptosis is caused by the activation of ER-specific caspase-12.Conclusion The findings from our study suggest that ISL-induced oxidative stress causes HeLa cell apoptosis via the mitochondrion-dependent and the ER stress-triggered signaling pathways. | YUAN Xuan ZHANG Bo GAN Lu WANG Zhen Hua YU Ba Cui LIU Liang Liang ZHENG Qiu Sheng WANGZhi Ping | 2013 | Biomedical and Environmental Sciences2013，26，4： | 8 |
| 16 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 17 | Tolerance analysis of multiple-element linear retrodirective cross-eye jamming显示文摘Tolerance sensitivity limits the practical application of the cross-eye jammer.Previous literature has demonstrated that retrodirective cross-eye jamming with multiple antenna elements possesses the advantage of loose tolerance requirements compared to traditional cross-eye jamming.However,the previous analysis was limited,because there are still some factors affecting the parameter tolerance of the multiple-element retrodirective cross-eye jamming(MRCJ)system and they have not been investigated completely,such as the loop difference,the baseline ratio and the jammer-to-signal ratio.This paper performs a comprehensive tolerance analysis of the MRCJ system with a nonuniformspacing linear array.Simulation results demonstrate the tolerance effects of the above influence factors and give reasonable advice for easing tolerance sensitivity. | LIU Tianpeng WEI Xizhang PENG Bo LIU Zhen SUN Bin GUAN Zhiqiang | 2020 | Journal of Systems Engineering and Electronics2020，31，3： | 7 |
| 18 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 19 | Jurassic Hornblende Gabbros in Dongga,Eastern Gangdese,Tibet:Partial Melting of Mantle Wedge and Implications for Crustal Growth显示文摘The Gangdese batholith, more than 2500 km in length, is composed mainly of JurassicMiocene igneous rocks. This batholith is one of the most important constituents of the Tibetan orogenesis and provides an ideal place for study of Neo-Tethyan ocean geodynamic evolution and plateau uplift. Recent studies on the Gangdese Jurassic felsic magmatism highlight its juvenile source. However, important aspects concerning the genesis of the juvenile magmatism and related deep geodynamic evolution are still unclear. Here, we report detailed petrological, geochronological, geochemical, whole-rock Sr-Nd isotopic, and in situ Sr-Hf isotopic data for a recently identified hornblende gabbro in the Dongga area, southern Lhasa sub-block. This hornblende gabbro is dominated by hornblende and plagioclase, dated at Early Jurassic(ca. 180–190 Ma), and characterized by a narrow compositional range in SiO_2(49.38wt%–52.27wt%), MgO(4.08wt%–7.00wt%), FeO(10.43wt%–11.77wt%), Na_2O(2.58wt%–3.51wt%), and K_2O(0.48wt%–1.53wt%). It has depleted isotopic signatures, with whole-rock(^(87)Sr/^(86)Sr)i ratios of 0.7033–0.7043, ε_(Nd)(t) values of +4.90 to +6.99, in situ plagioclase(^(87)Sr/^(86)Sr)i ratios of 0.7034–0.7042, and zircon ε_(Hf)(t) of +12.2 to +16.8. Our results integrated with published data suggest a model of Gangdese juvenile crustal growth by a subduction-related water-enriched mantle wedge. The hydrous partial melting of the lithosphere mantle was triggered by the dehydration of a Neo-Tethyan oceanic slab. This mafic magmatism emplaced in the middle-lower crust of intraoceanic arcs or active continental margins, leading to Jurassic juvenile crustal growth in southern Tibet. | XU Bo HOU Zengqian ZHENG Yuanchuan ZHOU Ye ZHOU Limin YANG Yu HAN Yanwei ZHEN Guo WU Changda | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 7 |
| 20 | Synthesis and plant-growth regulatory activities of novel imine derivatives containing 1H-1,2,4-triazole and thiazole rings显示文摘Eleven new imine derivatives 6 containing 1H-1,2,4-triazole and thiazole rings were synthesized by the condensation of 5-((1H- 1,2,4-triazol-1-yl)methyl)-4-tert-butylthiazol-2-amine with various substituted benzaldehydes.The structures of the title compounds were characterized by ~1H NMR,MS and elemental analysis.The plant-growth regulatory activities of these compounds were evaluated.The primary bioassay results indicated that these target compounds exhibited promising plant-growth regulatory activities... | Qin, Xue Yu, Hai Bo Dai, Hong Qin, Zhen Fang Zhang, Xin Bing, Gui Fang Wang, Ting Ting Fang, Jian Xin | 2010 | Chinese Chemical Letters2010，21，3： | 6 |
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