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| 1 | Volume change behavior of unsaturated soils under non-isothermal conditions显示文摘With the development of modern geotechnical engineering practices such as the construction of high level radioactive waste repositories, exploitation and utilization of geothermal resources, energy-saving buildings and underground storage of CO 2 , research into the influence of temperature on the basic mechanical properties of unsaturated soils has become an important issue internationally. By using the work expression and considering the influence of temperature on the basic properties of unsaturated soils, the average soil skeleton stress, modified suction and temperature were selected as state variables of generalized forces in thermodynamics and the soil skeleton strain, saturation and entropy were chosen as state variables of generalized flows conjugate to the variables of generalized forces. Based on the nonlinear multi-field coupled model and by using existing experimental results, an elastic-plastic constitutive model of unsaturated soils under non-isothermal conditions was developed to analyze the influence of temperature on the deformation properties of unsaturated soils. The model was used to predict and analyze the influence of suction and temperature on the deformation properties of unsaturated soils under isotropic conditions, and was successfully verified using experimental results. | CAI GuoQing ZHAO ChengGang LIU Yan LI Jian | 2011 | Chinese Science Bulletin2011，56，23： | 16 |
| 2 | A nonlinear multi-field coupled model for soils显示文摘A nonlinear multi-field coupled model for multi-constituent three-phase soils is derived by using the hybrid mixture theory. The balance equations with three levels (constituents, phases and the whole mixture soil) are set up under the assumption that soil is composed of multi-constituent elastic-plastic solid skeleton (which is different from the linearization method) and viscous liquid and ideal gas. With reasonable constitutive assumptions in such restrictive conditions as the principles of determinism, equipresence, material frame-indifference and the compatible principle in continuum mechanics, a theoretical framework of constitutive relations modeling three-phase soil in both non-equilibrium and equilibrium states is established, thus the closed field equations are formed. In the theoretical framework, the concept of effective generalized thermodynamic forces is introduced, and the nonlinear coupling constitutive relations between generalized dissipation forces and generalized flows within the system at nonequilibrium state are also presented. On such a basis, four special coupling relations, i.e., solid thermal elastic-plastic constitutive relation, liquid visco-elastic-plastic constitutive relation, the generalized Fourier’s law, and the generalized Darcy’s law are put forward. The generalized or nonlinear results mentioned above can degenerate into the linear coupling results given by Bennethum and Singh. Based on a specific dissipation function, the concrete form of generalized Darcy’s law is deduced, which may degenerate into the traditional form of Darcy’s law by neglecting the influence of skeleton deformation and temperature. Without considering temperature and other coupling effects, the nonlinear coupled model in this paper can degenerate into a soil elastic-plastic constitutive model. | CAI GuoQing ZHAO ChengGang LIU Yan LI Jian | 2011 | Science China(Technological Sciences)2011，54，5： | 15 |
| 3 | The input work expression and the thermodynamics-based modelling framework for unsaturated expansive soils with double porosity显示文摘In this paper, based on the porous media theory, the specific expressions of the total stress and the input work of unsaturated expansive soils with double porosity are proposed, and then the energy-conjugate variables are further derived. We make distinctions between the effects of capillary water and adsorbed water on the soil behaviour, as well as between the deformations of microand macrostructure. According to the derived input work expression and the work-energy-dissipation relations for an open multiphase thermodynamic system, we establish a thermodynamics-based modelling framework for unsaturated expansive soils with double porosity. | LI Jian ZHAO ChengGang CAI GuoQing ASREAZAD Saman XU Xi Frank HUANG QiDi | 2013 | Chinese Science Bulletin2013，58，27： | 10 |
| 4 | Apoptotic mechanism of premature ovarian failure and rescue effect of Traditional Chinese Medicine: a review显示文摘Social and environmental factors render premature ovarian failure(POF) as a major cause of decline or loss of female fertility. The natural pregnancy rate of patients with POF is only 5%-10%. Follicular atresia is the main factor in the pathogenesis of POF.Due to the unique ovarian physiological environment and follicular developmental processes, the apoptosis of ovarian granulosa cells and oocytes together cause follicular atresia, which involves the apoptosis-related internal and external pathways.Furthermore, during POF, apoptosis and oxidative stress forms a 'vicious circle', which involves a variety of changes between the molecules. The existing pharmaceutical preparations such as gonadal hormones are the basic methods for the treatment of POF, and the curative effect was affirmative;however, it was ineffective after withdrawn, while the long-term application led to adverse reactions. Traditional Chinese Medicine(TCM) has a history of treating gynecological diseases and infertility and has gained increasing attention. Studies have shown that compounds isolated from herbal medicine exerted a positive effect on follicular atresia caused by cell apoptosis that also improved the POF. The present study reviewed the mechanisms underlying the apoptosis in POF and elaborated the internal mechanism of TCM in the treatment of the condition. | CAI Liang ZONG Daokuan TONG Guoqing LI Li | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 10 |
| 5 | Constitutive modeling for unsaturated soils considering gas hardening effect显示文摘The influence of gases on unsaturated soils is discussed in the paper.First,the selection of stress state variables is discussed.It is shown that gas pressure as well as generalized effective stress and modified suction are required to construct a constitutive model of an unsaturated soil.The deformation mechanisms of solid,liquid and gas phases in soils are then investigated.It is realized that the deformation of gas phase interacts with the deformations of the other two phases in soils.Gas laws are used to describe the gas behavior.Similar to the other two phases in soil,the change of gas volume can be divided into an elastic part and a plastic part, and the latter part is then introduced to the soil hardening equation to reflect the impact of the gas on the soil.Then,a simple elasto-plastic model considering the gas effect for isotropic states is developed.Finally,the model predictions are given and compared with existing experimental data.A good agreement between them is found.Comparisons of the predictions between our model and Wheeler’s model are also performed. | LIU Yan ZHAO ChengGang CAI GuoQing HUANG Lu | 2011 | Chinese Science Bulletin2011，56，16： | 9 |
| 6 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 7 | Solubilities of 1-Methyl-3-(3-sulfopropyl)-imidazolium Hydrogen Sulfate in Selected Solvents显示文摘Ionic liquid 1-methyl-3-(3-sulfopropyl) -imidazolium hydrogen sulfate([C3SO3HMIM][HSO4]) was synthesized and characterized by infrared spectroscopy(IR) ,nuclear magnetic resonance(1H and 13C NMR) and ultraviolet-visible(UV-Vis) spectra. Its thermal stability was also examined by thermogravimetric analysis(TGA) and a differential scanning calorimeter(DSC) . The mole fraction solubilities of [C3SO3HMIM][HSO4]) in 12 selected solvents(n-pentane,n-hexane,n-heptane,benzene,toluene,ethylbenzene,acetone,2-butanone,3-methyl-2-butanone,tetrahydrofuran,ethyl acetate and dichloromethane) in the temperature range from 289.15 to 363.15 K were meas-ured using a static analytical method and correlated with an empirical equation. | CAI Shuangfei WANG Lisheng YAN Guoqing LI Yi | 2010 | Chinese Journal of Chemical Engineering2010，18，6： | 5 |
| 8 | Preparation and characterization of a specialized lunar regolith simulant for use in lunar low gravity simulation显示文摘Lunar in-situ resource utilization(ISRU)has been put on the agenda by many countries.Due to the special material nature and low gravity environment,the lunar regolith demonstrates significantly different behavior from terrestrial geomaterials.However,the systematic understanding of its geotechnical behavior is now seriously restricted by the scarcity of lunar regolith and the difficulty in simulating lunar gravity.A new lunar regolith simulant,termed as China University of Mining and Technology Number One(CUMT-1),has been developed to recover properties of the lunar regolith and simulate the lunar gravity by adopting the recently advanced geotechnical magnetic-similitude-gravity model testing(GMMT)method.The CUMT-1 simulant was prepared by reproducing the in-situ formation and fragmentation of the lunar matrix,which plays a key role in the irregular particle morphology.The mineralogical compositions,particle morphology and gradation,specific gravity,bulk density,void ratio,shear strength,and compressibility were determined.After quantifying the magnetization and magnetic-similitude-gravity characteristics,an application of the cone penetration resistance under low gravity was further given.The obtained results are compared to the values known for lunar regolith samples and other simulants,which demonstrates promising characteristics for use in geotechnical engineering-based and scientificbased applications,especially considering the influence of lunar gravity. | Ruilin Li Guoqing Zhou Kang Yan Jun Chen Daqing Chen Shangyue Cai Pin-Qiang Mo | 2022 | International Journal of Mining Science and Technology2022，32，1： | 4 |
| 9 | A model considering solid-fluid interactions stemming from capillarity and adsorption mechanisms in unsaturated expansive clays显示文摘Solid-fluid interactions in unsaturated expansive clays can be divided into capillarity and adsorption effects based on their physical mechanisms. Most constitutive models for unsaturated soils are proposed on the basis of the capillarity mechanism, ignoring the contributions of the adsorption effect to mechanical and hydraulic behaviors. For expansive clays, however, the adsorption effect which leads to more complex behavioral characteristics than that in low plasticity clays cannot be ignored. In the light of this, a new binary-medium model for unsaturated expansive clays is proposed, involving a consideration of the solid-fluid interactions stemming from the capillary and the adsorption mechanisms at the same time.Firstly, we assume that expansive clay is a mixture of two ideal parts, i.e. the ideal capillarity part and the ideal adsorption part, and then an ideal capillarity model and an ideal adsorption model, each of which is available for the corresponding ideal part, are established. Furthermore, a participation function is used to reflect the degrees of capillarity effect and adsorption effect. Finally, predictions are performed on the results of the consolidation tests and the cyclical controlled-suction tests published in literature.After comparing predicted results with test results, it is illustrated that the established model can quantitatively predict mechanical and hydraulic behaviors in expansive clays. | Jian Li Chenggang Zhao Guoqing Cai Yanxin Guo | 2014 | Chinese Science Bulletin2014，59，26： | 4 |
| 10 | A wireless, implantable optoelectrochemical probe for optogenetic stimulation and dopamine detection显示文摘Physical and chemical technologies have been continuously progressing advances in neuroscience research.The development of research tools for closed-loop control and monitoring neural activities in behaving animals is highly desirable.In this paper,we introduce a wirelessly operated,miniaturized microprobe system for optical interrogation and neurochemical sensing in the deep brain.Via epitaxial liftoff and transfer printing,microscale light-emitting diodes(micro-LEDs)as light sources and poly(3,4-ethylenedioxythiophene)polystyrene sulfonate(PEDOT:PSS)-coated diamond films as electrochemical sensors are vertically assembled to form implantable optoelectrochemical probes for real-time optogenetic stimulation and dopamine detection capabilities.A customized,lightweight circuit module is employed for untethered,remote signal control,and data acquisition.After the probe is injected into the ventral tegmental area(VTA)of freely behaving mice,in vivo experiments clearly demonstrate the utilities of the multifunctional optoelectrochemical microprobe system for optogenetic interference of place preferences and detection of dopamine release.The presented options for material and device integrations provide a practical route to simultaneous optical control and electrochemical sensing of complex nervous systems. | Changbo Liu Yu Zhao Xue Cai Yang Xie Taoyi Wang Dali Cheng Lizhu Li Rongfeng Li Yuping Deng He Ding Guoqing Lv Guanlei Zhao Lei Liu Guisheng Zou Meixin Feng Qian Sun Lan Yin Xing Sheng | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 11 | Increased lateral root formation by CRISPR/Cas9-mediated editing of arginase genes in cotton显示文摘Dear Editor,Proper development of plant roots is critical for primary physiological functions,including water and nutrient absorption and uptake,physical support,and carbohydrate storage(Zhang et al.,2010).Crop root systems act as the key organ for sensing and response to abiotic and biotic stresses.Previous studies of crop root system development suggest that increased lateral root formation(LRF)could | Yanling Wang Zhigang Meng Chengzhen Liang Zhaohong Meng Yuan Wang Guoqing Sun Tao Zhu Yongping Cai Sandui Guo Rui Zhang Yi Lin | 2017 | Science China(Life Sciences)2017，60，5： | 3 |
| 12 | In vitro induction of mouse meningeal-derived iPS cells into neural-like cells显示文摘Previous research has shown that mouse embryonic stem (ES) cells can be induced to form neural cells in adherent monocultures.In this study,pluripotent stem (iPS) C5 cells derived from meningeal membranes were converted successfully into neural-like cells using the same protocol generally used for ES cells.Meningeal-iPS C5 cells were induced to express neural markers Sox1,Sox3,Pax6,Nestin and Tuj1 and to reduce the expression of ES markers Oct4 and Nanog during neural differentiation,and can be differentiated into Pax6 and Nestin positive neural progenitors,and further into neuronal,astrocytic,and oligodendrocytic cells.In vitro differentiation of iPS cells into patient-specific neural cells could serve as a model to study mechanisms of genetic diseases and develop promising candidates for therapeutic applications in dysfunctional or aging neural tissues.Meningeal cells express a high level of the embryonic master regulator Sox2,allowing them to be reprogrammed into iPS cells more easily than other somatic cells. | XU Jing WANG Hao LIANG Tao CAI XiangSheng RAO XiuRong HUANG ZhenBo SHENG GuoQing | 2011 | Chinese Science Bulletin2011，56，15： | 2 |
| 13 | TGFβ signaling hyperactivation-induced tumorigenicity during the derivation of neural progenitors from mouse ESCs显示文摘pluripotent 干细胞(PSC ) 的临床的治疗基于移植被 teratomas 或肿瘤的经常的开发在动物模型和临床的病人妨碍了。因此,在干细胞治疗澄清 carcinogenesis 的机制为减少 tumorigenicity 的风险是很重要的。这里,我们区分 Oct4-GFP 老鼠胚胎的干细胞(mESCs ) 进神经祖先房间(NPC ) 并且发现少数 Oct4+ 房间连续地以 Oct4+ 状态被支撑。这些房间能在标准转换字符媒介被充实并且增殖。有趣地,这些充实的房间的区别潜力紧与许多更高的 tumorigenic 活动被限制,它是因此定义的同样区别抵抗的转换字符(医生转换字符) 。Transcriptomic 和 epigenomic 分析证明医生转换字符被初发的细菌描绘像房间的基因签名(Dazl, Rec8, Stra8, Blimp1,等等) 并且从 mESCs 不同的特定的 epigenetic 模式。而且,医生转换字符拥有细菌房间潜力产生 Sycp3+ haploid 房间并且能居住在 busulfan 导致的没有精子的输精管。最后,我们发现 TGF 发信号是在 TGF 发信号的医生转换字符,和抑制的 overactivated 由导致医生转换字符的完整的区别消除导出 mESC 的 NPC 的 tumorigenicity。这些数据表明那像房间的医生转换字符是的这些 TGF-hyperactivated 细菌为导出转换字符的目标房间治疗的 tumorigenicity 和在导出转换字符的 NPC 移植发信号的 TGF 的那抑制的主要贡献者能急速地减少肿瘤开发的风险。 | Xianfa Yang Ran Wang Xiongjun Wang Guoqing Cai Yun Qian Su Feng Fangzhi Tan Kun Chen Ke Tang Xingxu Huang Naihe Jing Yunbo Qiao | 2018 | Journal of Molecular Cell Biology2018，10，3： | 2 |
| 14 | Behaviour of granular matter under gravity-induced stress gradient:A two-dimensional numerical investigation显示文摘Gravity is the most important load source in mining and geotechnical engineering,which causes both the stress level and stress gradient inside geomaterials.Different from the stress level,the influence of gravity-induced stress gradient on the behaviour of the material is still unknown.An in-deep study on it will help to promote the understanding of material behaviour,especially for those cases related to unconventional gravity such as terrestrial ng physical modelling and extraterrestrial resource exploitation(g is the terrestrial gravitational acceleration).In this study,a high-order homogenization for granular materials is proposed at first,in which the stress gradient is drawn into the constitutive representation by adopting a representative volume element(RVE).The consolidation and shear strength behaviour of RVE are then investigated by performing numerical biaxial tests.The results show that all the compressibility,shear strength,shear stiffness,volumetric deformation,and critical state behaviour show a stress gradient dependence.A coupling between stress gradient,stress level,and material properties is also observed.These observations suggest that,besides the stress level,extra attention needs to be paid to material responses related to stress gradient during engineering practices. | Ruilin Li Guoqing Zhou Pin-Qiang Mo Matthew R.Hall Jun Chen Daqing Chen Shangyue Cai | 2021 | International Journal of Mining Science and Technology2021，31，3： | 2 |
| 15 | Bortezomib in combination with dexamethasone and subsequent thalidomide for newly-diagnosed multiple myeloma: A Chinese experience显示文摘 | Weiyan Zheng Guoqing Wei Xiujin Ye Jingsong He Li Li Wenjun Wu Jimin Shi Jie Zhang Weijia Huang Wanzhuo Xie Yi Luo Xingkui Xue Maofang Lin He Huang Zhen Cai | 2009 | Leukemia Research2009，，12： | 1 |
| 16 | Special magnetic phenomena in heavily doped La_(0.7-x)Dy_xSr_(0.3)MnO_3 system显示文摘The magnetism in heavily Dy doped La0.7-xDyxSr0.3MnO3(0.40≤x≤0.70)system is studied in this paper.The M-T relation seems to be complicated with the increase of x.For sample with x=0.40,AFM behavior exists at T≤TN and M-T curves under zero field cooling(ZFC)and field cooling(FC)exhibit typical behavior of spincluster glass state above TN.For the sample with x=0.50,the M-T curve under ZFC exhibits a valley at a low temperature while the M-T curve under FC exhibits the negative magnetization below TN.For samples with x=0.60,0.70,their ZFC M-T curves are similar to that of x=0.50,but the FC M-T curves do not exhibit negative values any more.All the peculiar phenomena above are well explained by Néel double-lattice model combined with M-H relation at typical temperatures.The molecular field theory fits well the negative magnetization for x=0.50. | LIU Ning 1,2 ,YAN GuoQing 1,3 ,CAI ZhiRang 1 ,PI Li 2 ,ZHANG Bei 2 &TONG Wei 2 1 Department of Physics,Suzhou College,Suzhou 234000,China 2 Structure Research Laboratory,University of Science and Technology of China,Hefei 230026,China 3 National Laboratory of Solid State Microstructures,Physics Department,Nanjing University,Nanjing 210093,China | 2008 | Science China(Physics,Mechanics & Astronomy)2008，51，1： | 1 |
| 17 | Three-dimensional concentration field imaging in a swirling flame via endoscopic volumetric laser-induced fluorescence at 10-kHz-rate显示文摘Optical combustion diagnostics are indispensable tools to investigate flame dynamics and excavate in-situ quantities of flames,such as velocity,temperature,concentration of key intermediates and pressure without introducing probe perturbation.For example,velocity and flame temperature can be obtained using techniques such as particle image velocimetry,coherent anti-Stokes Raman scattering spectroscopy,Rayleigh scattering and tunable diode laser absorption spectroscopy,respectively. | WANG Qian LIU HeCong LIU XunChen WANG SiRui FU Chen WANG GuoQing GAO Yi CAI WeiWei QI Fei | 2020 | Science China(Technological Sciences)2020，63，10： | 1 |
| 18 | Transient Perform- ances Analysis and Experiment for Optical Current Transformer 显示文摘 | LI Hongbo CAI Xingguo ZHANG Guoqing | 2014 | Lecture Notes in Electrical Engineering2014，258，： | 1 |
| 19 | Simultaneous Detection of Major Drug Resistance Mutations in the Protease and Reverse Transcriptase Genes for HIV-1 Subtype C by Use of a Multiplex Allele-Specific Assay显示文摘 | Guoqing Zhang Fangping Cai Zhiyong Zhou Joshua DeVos Nick Wagar Karidia Diallo Isaac Zulu Nellie Wadonda-Kabondo Jeffrey S. A. Stringer Paul J. Weidle Clement B. Ndongmo Izukanji Sikazwe Abdoulaye Sarr Matthew Kagoli John Nkengasong Feng Gao Chunfu Yang | 2013 | Journal of Clinical Microbiology2013，，11： | 1 |
| 20 | A permeability function for unsaturated soils with different initial densities 显示文摘 | Cai Guoqing Zhou Annan Sheng Daichao | 2014 | Canadian Geotechnical Journal2014，51，12： | 1 |
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