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| 1 | A Transcriptional Network Promotes Anthocyanin Biosynthesis in Tomato Flesh显示文摘Dietary anthocyanins are important health-promoting antioxidants that make a major contribution to the quality of fruits. It is intriguing that most tomato cultivars do not produce anthocyanins in fruit. However, the purple tomato variety Indigo Rose, which has the dominant Aft locus combined with the recessive atv locus from wild tomato species, exhibits light-dependent anthocyanin accumulation in the fruit skin. Here, we report that Aft encodes a functional anthocyanin activator named SlAN2-like, while atv encodes a nonfunctional version of the anthocyanin repressor SlMYBATV. The expression of SlAN2-like is responsive to light, and the functional SlAN2-like can activate the expression of both anthocyanin biosynthetic genes and their regulatory genes, suggesting that SlAN2-like acts as a master regulator in the activation of anthocyanin biosynthesis. We further showed that cultivated tomatoes contain nonfunctional alleles of SlAN2-like and therefore fail to produce anthocyanins. Consistently, expression of a functional SlAN2-like gene driven by the fruit-specific promoter in a tomato cultivar led to the activation of the entire anthocyanin biosynthesis pathway and high-level accumulation of anthocyanins in both the peel and flesh. Taken together, our study exemplifies that efficient engineering of complex metabolic pathways could be achieved through tissue-specific expression of master transcriptional regulators. | Chuanlong Sun Lei Deng Minmin Du Jiuhai Zhao Qian Chen Tingting Huang Hongling Jiang Chang-Bao Li Chuanyou Li | 2020 | Molecular Plant2020，13，1： | 17 |
| 2 | Collagen-binding basic fibroblast growth factor improves functional remodeling of scarred endometrium in uterine infertile women: a pilot study显示文摘Intrauterine adhesion(IUA) is a common cause of uterine infertility and one of the most severe clinical features is endometrial fibrosis namely endometrial scarring for which there are few cures currently. Blocked angiogenesis is the main pathological change in the scarred endometrium. The fibroblast growth factor 2(b FGF), a member of FGF family, is usually applied to promote healing of refractory ulcer and contributes to angiogenesis of tissues. In this study, the sustained-release system of b FGF100 μg was administrated around scarred endometrium guiding by ultrasound every 4 weeks in 18 patients(2–4 times). Results showed that after treatment, the menstrual blood volume, endometrial thickness and the scarred endometrial area were improved.Histological study showed blood vessel density increased obviously. Three patients(3/18) achieved pregnancy over 20 gestational weeks. Therefore, administrating the b FGF surrounding scarred endometrium may provide a new therapeutic approach for the patients with endometrial fibrosis. | Peipei Jiang Xiaoqiu Tang Huiyan Wang Chenyan Dai Jing Su Hui Zhu Minmin Song Jingyu Liu Ziqing Nan Tong Ru Yaling Li Jingmei Wang Jun Yang Bing Chen Jianwu Dai Yali Hu | 2019 | Science China(Life Sciences)2019，62，12： | 16 |
| 3 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 4 | A novel synthesis strategy to improve cycle stability of LiNio.8Mno.1Co0.1O2 at high cut-off voltages through core-shell structuring显示文摘Nickel-rich cathode materials have attracted considerable interest because of their high specific capacities,voltage ranges,and low cost.However,serious capacity attenuation and poor rate performance limit their application.This study proposes a novel strategy to improve the cycle stability of the nickel-rich LiNi0.sCo0.1Mn0.1O2(NCM811)layer material by designing core-shell LiNio.sCoo.1 Mno.102(CS-NCM811).CS-NCM811 is designed by the characteristic reaction between dimethylglyoxime(C4H8N2O2)and nickel ion to form Ni(C4H7N2O2)2-The CS-NCM811 is characterized with high nickel content in its core and high manganese content on its surface,leading to a high capacity and excellent cycle stability.The capacity retention of CS-NCM811 was 72.8%,much higher than that of NCM811(47.1%)after 500 cycles at a rate of 5 C.Not only is this method a no vel strategy to desig n high capacity cathode materials but also provides some new in sights into the cycle stability of nickel-rich layered cathode materials. | Kang Wu Qi Li Rongbin Dang Xin Deng Minmin Chen Yu Lin Lee Xiaoling Xiao Zhongbo Hu | 2019 | Nano Research2019，12，10： | 12 |
| 5 | LORELEI-LIKE GPI-ANCHORED PROTEINS 2/3 Regulate Pollen Tube Growth as Chaperones and Coreceptors for ANXUR/BUPS Receptor Kinases in Arabidopsis显示文摘Pollen tube growth is crucial for successful fertilization.In Arabidopsis thaliana,the ANXUR(ANX)/BUPS receptor kinase complex controls and maintains pollen tube growth in response to autocrine rapid alkalin-ization factor 4/19(RALF4/19)signaling;however,the molecular and cellular mechanisms underlying the ANX/BUPS-mediated regulation of pollen tube growth remain unclear.In this study,we found that pollen-specific LORELEI-like GPI-anchored proteins 2 and 3(LLG2/3)promote pollen tube growth in vitro and in vivo.LLG2/3 interacte with ANX/BUPS in a RALF4-concentration-dependent manner,suggesting that ANX/BUPS and LLG2/3 might form a receptor-coreceptor complex for perceiving RALF peptide signals.Disruption of the ANX/BUPS-LLG2/3 interaction led to the cytoplasmic retention of ANX1/2,in either llg2/3 knockdown mutants or in anx1/2 mutants lacking the J region,which mediates the ANX/BUPS-LLG2/3 interaction.Moreover,we found that RALF4 induced the production of reactive oxygen species(ROS),which stimulate pollen tube growth and reduce pollen burst rate.ROS levels are reduced in the pollen tubes of LLG2/3 RNAi lines,and application of exogenous H2O2 could partially rescue the defective pollen tube growth of LLG2/3 RNAi lines.Taken together,our study identifies LLG2/3 as novel regulatory components of pollen tube growth,and shows that they chaperone ANX/BUPS for secretion to the apical plasma membrane of pollen tube and act as coreceptors of ANX/BUPS in the acti-vation of ROS production for promoting pollen tube growth. | Hanqian Feng Chen Liu Rong Fu Minmin Zhang Hui Li Lianping Shen Qiqi Wei Xiang Sun Lin Xu Bin Ni Chao Li | 2019 | Molecular Plant2019，12，12： | 10 |
| 6 | Epigenetics in the pathogenesis of diabetic nephropathy显示文摘Diabetic nephropathy(DN),which is a common microvascular complication with a high incidence in diabetic patients,greatly increases the mortality of patients.With further study on DN,it is found that epigenetics plays a crucial role in the pathophysiological process of DN.Epigenetics has an important impact on the development of DN through a variety of mechanisms,and promotes the generation and maintenance of metabolic memory,thus ultimately leading to a poor prognosis.In this review we discuss the methylation of DNA,modification of histone,and regulation of non-coding RNA involved in the progress of cell dysfunction,inflammation and fibrosis in the kidney,which ultimately lead to the deterioration of DN. | Xue Li Lihong Lu Wenting Hou Ting Huang Xiangyuan Chen Jie Qi Yanjun Zhao Minmin Zhu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，2： | 6 |
| 7 | SET8 is involved in the regulation of hyperglycemic memory in human umbilical endothelial cells显示文摘 | Xiangyuan Chen Qichao Wu Hui Jiang Jiaqiang Wang Yanjun Zhao Yajun Xu Minmin Zhu1 | 2018 | Acta Biochimica et Biophysica Sinica2018，50，7： | 5 |
| 8 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 9 | Biochemistry of mammalian ferritins in the regulation of cellular iron homeostasis and oxidative responses显示文摘Ferritin,an iron-storage protein,regulates cellular iron metabolism and oxidative stress.The ferritin structure is characterized as a spherical cage,inside which large amounts of iron are deposited in a safe,compact and bioavailable form.All ferritins readily catalyze Fe(II)oxidation by peroxides at the ferroxidase center to prevent free Fe(II)from participating in oxygen free radical formation via Fenton chemistry.Thus,ferritin is generally recognized as a cytoprotective stratagem against intracellular oxidative damage.The expression of cytosolic ferritins is usually regulated by iron status and oxidative stress at both the transcriptional and post-transcriptional levels.The mechanism of ferritin-mediated iron recycling is far from clarified,though nuclear receptor co-activator 4(NCOA4)was recently identified as a cargo receptor for ferritin-based lysosomal degradation.Cytosolic ferritins are heteropolymers assembled by H-and L-chains in different proportions.The mitochondrial ferritins are homopolymers and distributed in restricted tissues.They play protective roles in mitochondria where heme-and Fe/S-enzymes are synthesized and high levels of ROS are produced.Genetic ferritin disorders are mainly related to the L-chain mutations,which generally cause severe movement diseases.This review is focused on the biochemistry and function of mammalian intracellular ferritin as the major iron-storage and anti-oxidation protein. | Jianlin Zhang Xuehui Chen Juanji Hong Aifa Tang Yang Liu Ni Xie Guohui Nie Xiyun Yan Minmin Liang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
| 10 | Integration of meta-QTL discovery with omics: Towards a molecular breeding platform for improving wheat resistance to Fusarium head blight显示文摘Fusarium head blight(FHB) is a global wheat disease that devastates wheat production. Resistance to FHB spread within a wheat spike(type Ⅱ resistance) and to mycotoxin accumulation in infected kernel(type Ⅲ resistance) are the two main types of resistance. Of hundreds of QTL that have been reported, only a few can be used in wheat breeding because most show minor and/or inconsistent effects in different genetic backgrounds. We describe a new strategy for identifying robust and reliable meta-QTL(mQTL)that can be used for improvement of wheat FHB resistance. It involves integration of mQTL analysis with mQTL physical mapping and identification of single-copy markers and candidate genes. Using metaanalysis, we consolidated 625 original QTL from 113 publications into 118 genetic map-based mQTL(gmQTL). These gmQTL were further located on the Chinese Spring reference sequence map. Finally, 77 high-confidence mQTL(hcmQTL) were selected from the reference sequence-based mQTL(smQTL).Locus-specific single nucleotide polymorphism(SNP) and simple sequence repeat(SSR) markers and17 genes responsive to FHB were then identified in the hcmQTL intervals by combined analysis of transcriptomic and proteomic data. This work may lead to a comprehensive molecular breeding platform for improving wheat resistance to FHB. | Tong Zheng Chen Hua Lei Li Zhengxi Sun Minmin Yuan Guihua Bai Gavin Humphreys Tao Li | 2021 | The Crop Journal2021，9，4： | 4 |
| 11 | Tetrahydroisoquinolines as novel histone deacetylase inhibitors for treatment of cancer显示文摘Histone acetylation is a critical process in the regulation of chromatin structure and gene expression.Histone deacetylases(HDACs)remove the acetyl group,leading to chromatin condensation and transcriptional repression.HDAC inhibitors are considered a new class of anticancer agents and have been shown to alter gene transcription and exert antitumor effects.This paper describes our work on the structural determination and structure-activity relationship(SAR)optimization of tetrahydroisoquinoline compounds as HDAC inhibitors.These compounds were tested for their ability to inhibit HDAC 1,3,6 and for their ability to inhibit the proliferation of a panel of cancer cell lines.Among these,compound 82 showed the greatest inhibitory activity toward HDAC 1,3,6 and strongly inhibited growth of the cancer cell lines,with results clearly superior to those of the reference compound,vorinostat(SAHA).Compound 82 increased the acetylation of histones H3,H4 and tubulin in a concentration-dependent manner,suggesting that it is a broad inhibitor of HDACs. | Danqi Chen Aijun Shen Guanghua Fang Hongchun Liu Minmin Zhang Shuai Tang Bing Xiong Lanping Ma Meiyu Geng Jingkang Shen | 2016 | Acta Pharmaceutica Sinica B2016，6，1： | 4 |
| 12 | 印度和西北太平洋夏季风在年际变化强度和季风-ENSO准两年关系方面的对比显示文摘印度夏季风和西北太平洋夏季风是亚洲季风系统的重要组成部分,研究这两个季风的变异规律具有重要的科学和现实意义。我们在研究中发现热带大西洋海温的影响在最近年代的显著增强可以激发印度和西北太平洋夏季风之间的‘跷跷板’现象,引起这两个季风在年际变化强度和季风–ENSO准两年关系方面的年代际反位相变化。在80年代中期之后(之前),ENSO和热带大西洋(热带印度洋)海表面温度具有更强的耦合,从而支持西北太平洋夏季风(印度夏季风)可以表现出更强的年际变化强度和季风–ENSO准两年关系。在预测未来的亚洲夏季风变化时,热带大西洋海温的影响可能需要给予更多的考虑。 | CHEN Baiyang WANG Lei WU Minmin | 2020 | Atmospheric and Oceanic Science Letters2020，13，5： | 3 |
| 13 | Microencapsulation of stearic acid with polymethylmethacrylate using iron(Ⅲ) chloride as photo-initiator for thermal energy storage显示文摘Aiming to identify the validity of fabricating microencapsulated phase change material(PCM) with polymethylmethacrylate(PMMA) by ultraviolet curing emulsion polymerization method using iron(III) chloride as photoinitiator,SA/PMMA microcapsules were prepared and various techniques were employed to determine the ignition mechanism,structural characteristics and thermal properties of the composite.The results shown that the microcapsules containing SA with maximum percentage of 52.20 wt% formed by radical mechanism and only physical interactions existed in the components both in the prepared process and subsequent use.The phase change temperatures and latent heats of the microencapsulated SA were measured as 55.3 °C and 102.1 J·g^(-1) for melting,and 48.8 °C and 102.8 J·g^(-1) for freezing,respectively.Thermal gravimetric analysis revealed that SA/PMMA has good thermal durability in working temperature range.The results of accelerated thermal cycling test are all shown that the SA/PMMA have excellent thermal reliability and chemical stability although they were subjected 1000 melting/freezing cycles.In summary,the comparable thermal storage ability and good thermal reliability facilitated SA/PMMA to be considered as a viable candidate for thermal energy storage.The successful fabrication of SA/PMMA capsules indicates that ferric chloride is a prominent candidate for synthesizing PMMA containing PCM composite. | Ting Zhang Minmin Chen Yu Zhang Yi Wang | 2017 | Chinese Journal of Chemical Engineering2017，25，10： | 3 |
| 14 | Nalmefene attenuates malignant potential in colorectal cancer cell via inhibition of opioid receptor显示文摘吗啡被要求在在外科手术前的时期期间支持肿瘤生长和转移的一个风险因素,和肿瘤房间的高 glycolysis 被证明加速肿瘤前进。在这研究,我们调查了是否 nalmefene,一个 opioid 受体禁止者,能通过影响细胞 glycolysis 禁止 CT26 结肠癌细胞生长。CCK8 和 transwell 迁居试金证明 nalmefene 以一种集中依赖者方式禁止了 CT26 房间生存能力和移植。细胞外的使发酸率和氧消费率证明 nalmefene 禁止了 CT26 房间的 glycolysis。而且,西方的污点分析和量的即时 PCR 表明 nalmefene 减少了与 glycolysis 有关的酶的表情。流动 cytometry 结果揭示了那细胞内部的钙(Ca 2+) 水平被 nalmefene 改变,西方的污点分析证明 nalmefene 减少了 calmodulin 表示和 calcium/calmodulin 依赖者蛋白质 kinases II (CaMK II ) phosphorylation,因此禁止 serine/threonine kinase (AKT ) 肝糖 synthase kinase-3 (GSK-3 ) 小径。而且, KN93 的效果, CaMK II 的一个禁止者,类似于 nalmefene,和 nalmefene 的反肿瘤效果的效果能被吗啡抵抗。在结论, nalmefene 的反肿瘤效果可以被禁止 opioid 受体和下面调整的 calmodulin 表示和 CaMK II phosphorylation 完成,因此禁止 AKT-GSK-3 小径和 CT26 房间的 glycolysis。 | Qichao Wu Xiangyuan Chen Jiaqiang Wang Pengfei Sun Meilin Weng Wankun Chen Zhirong Sun Minmin Zhu Changhong Miao | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 2 |
| 15 | High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression显示文摘Hyperglycemia-mediated reactive oxygen species(ROS)accumulation plays an important role in hyperglycemia-induced endothelial injury.Kelch-like ECH-associated protein 1(Keap1)/nuclear factor erythroid 2-related factor 2(Nrf2)/antioxidant response element(ARE)pathway inhibition participates in hyperglycemia-induced ROS accumulation.Our previous study indicated that SET8 overexpression inhibits high glucose-mediated ROS accumulation in human umbillical vein endothelial cells(HUVECs).In the present study,we hypothesize that SET8 may play a major role in high glucose-induced ROS accumulation via modulation of Keap1/Nrf2/ARE pathway.Our data indicated that high glucose mediated cell viability reduction,ROS accumulation,and Nrf2/ARE signal pathway inhibition via upregulation of Keap1 expression in HUVECs.Moreover,high glucose inhibited the expressions of SET8 and H4K20me1(a downstream target of SET8).SET8 overexpression improved high glucose-mediated Keap 1/Nrf2/ARE pathway inhibition and endothelial oxidation.Consistently,the effects of sh-SET8 were similar to that of high glucose treatment and were reversed by si-Keap1.A mechanistic study found that H4K20me1 was enriched at the Keap1 promoter region.SE T8 overexpression attenuated Keap1 promoter activity and its expression,while mutant SET8 R259G did not affect Keap1 promoter activity and expression.The results of this study demonstrated that SET8 negatively regulates Keap1 expression,thus participating in high glucose-mediated Nrf2/ARE signel pathway inhibition and oxidative injury in HUVECs. | Xiangyuan Chen Jie Qi Qichao Wu Hui Jiang Jing Wang Wankun Chen Anrong Mao Minmin Zhu | 2020 | Acta Biochimica et Biophysica Sinica2020，52，5： | 2 |
| 16 | Design and analysis of an electrical variable transmission for a series-parallel hybrid electric vehicle显示文摘 | CHEN Li ZHU Futang ZHANG Minmin | | 0，，05： | 1 |
| 17 | Crystal Growth and Characterization of Fluorinated Perylene Diimides显示文摘 | HUANG Jiachi LI Hanying MO Xiong SHI Minmin WANG Mang CHEN Hongzheng | 2014 | Chemical Research in Chinese Universities2014，30，1： | 1 |
| 18 | A Method for Software Vulnerability Detection Based on Improved Control Flow Graph显示文摘With the rapid development of software technology, software vulnerability has become a major threat to computer security. The timely detection and repair of potential vulnerabilities in software, are of great significance in reducing system crashes and maintaining system security and integrity. This paper focuses on detecting three common types of vulnerabilities: Unused_Variable, Use_of_Uninitialized_Variable, and Use_After_ Free. We propose a method for software vulnerability detection based on an improved control flow graph(ICFG) and several predicates of vulnerability properties for each type of vulnerability. We also define a set of grammar rules for analyzing and deriving the three mentioned types of vulnerabilities, and design three vulnerability detection algorithms to guide the process of vulnerability detection. In addition, we conduct cases studies of the three mentioned types of vulnerabilities with real vulnerability program segments from Common Weakness Enumeration(CWE). The results of the studies show that the proposed method can detect the vulnerability in the tested program segments. Finally, we conduct manual analysis and experiments on detecting the three types of vulnerability program segments(30 examples for each type) from CWE, to compare the vulnerability detection effectiveness of the proposed method with that of the existing detection tool Cpp Check. The results show that the proposed method performs better. In summary, the method proposed in this paper has certain feasibility and effectiveness in detecting the three mentioned types of vulnerabilities, and it will also have guiding significance for the detection of other common vulnerabilities. | ZHOU Minmin CHEN Jinfu LIU Yisong ACKAH-ARTHUR Hilary CHEN Shujie ZHANG Qingchen ZENG Zhifeng | 2019 | Wuhan University Journal of Natural Sciences2019，24，2： | 1 |
| 19 | Flow cytometric assessment of the effects of chlorine, chloramine, and UV on bacteria by using nucleic acid stains and 5-cyano-2,3-ditolyltetrazolium chloride显示文摘 | Xuebiao Nie Wenjun Liu Mo Chen Minmin Liu Lu Ao | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 1 |
| 20 | Crystallization Behaviours and Morphology of Polypropylene Conraining Nucleating and Degradation Agents显示文摘 | Yu Jie Zhang Minmin Chen Xiaolang | 2009 | Journal of Macromolecules Science:Part B2009，48，： | 1 |
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