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| 1 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 2 | Three-Dimensional Heat Transfer Analysis for A Thermal Energy Storage Canister显示文摘High temperature latent thermal storage is one of the critical techniques for a solar dynamic power system. This paper presents results from heat transfer analysis of a phase change salt containment canister A three-dimensional analysis program is developed to model heat transfer in a PCM canister. Analysis include effects of asymmetric circumference heat flux, conduction in canister walls, liquid PCM and solid PCM, void volume change and void location, and conduction and radiation across PCM vapor void. The PCM phase change process is modeled using the enthalpy method and the simulation results are compared with those of other two- dimensional investigations. It’s shown that there are large difference with two-dimensional analysis, therefore the three-dimensional model is necessary for system design of high temperature latent thermal storage. | Hou Xinbin, Xin Yuming, Yang Chunxin, Yuan Xiugan (Dept.of Flight Vehicle Design and Applied Mechanics, Beijing University of Aeronautics and Astronautics, Beijing, 100083.) Dong Keyong (Stirling Engine Research and Develop Center, Shanghai Marine Diesel | 2001 | Journal of Thermal Science2001，10，1： | 9 |
| 3 | Herbal compatibility of Traditional Chinese Medical formulas for acquired immunodeficiency syndrome显示文摘OBJECTIVE:Because herbal compatibility is one of the most important reasons why Traditional Chinese Medcine(TCM) formulas are effective for acquired immunodeficiency syndrome(AIDS),our study aimed to determine the compatibility of herbs based on published AIDS clinical research in Chinese periodicals.To achieve this aim,we designed a new data-mining algorithm according to TCM data characteristics.METHODS:We found 25 clinical AIDS studies,all using Chinese herbs for treatment,in the Traditional Chinese Medicine Database System,and information on diagnosis and treatment was extracted.To find out herbal compatibility,especially the formulae for herbal combinations,we proposed an improved association rule algorithm based on the frequency of combinations.In this algorithm,all the compatibility relationships were displayed in a tree structure,by which the relationship between formulas and their derivation could be clearly inferred.RESULTS:Data analysis showed that approximately 100 herbs have been used for treating AIDS.Based on the whole herb compatibility tree,we calculated a basic formula for AIDS:Huang Qi combined with Ren Shen,Fu Ling,Bai Zhu,Bai Zhu,Dang Gui,and Bai Shao.This formula,deriving from most of clinical prescriptions,and was chosed by most of clinicians for AIDS treatment.From data mining we found that Qi replenishment and detoxification were the main treatment principles,which coincided with the AIDS pathological mechanism in which immune function is destroyed by human immunodeficiency virus(HIV).CONCLUSIONS:Our data-mining results suggest that the core TCM treatment of AIDS is replenishing Qi and detoxification,by which AIDS patients' immune system may be enhanced.Compatibility of Huang Qi with some frequently-used herbs have shown real efficacy in clinical practice,which warrants pharmacological research in the future. | Meng Cui Jinghua Li Haiyan Li Chunxin Song | 2012 | Journal of Traditional Chinese Medicine2012，32，3： | 5 |
| 4 | Experimental study on uplift mechanism of pipeline buried in sand using high-resolution fiber optic strain sensing nerves显示文摘Reliable assessment of uplift capacity of buried pipelines against upheaval buckling requires a valid failure mechanism and a reliable real-time monitoring technique.This paper presents a sensing solution for evaluating uplift capacity of pipelines buried in sand using fiber optic strain sensing(FOSS)nerves.Upward pipe-soil interaction(PSI)was investigated through a series of scaled tests,in which the FOSS and image analysis techniques were used to capture the failure patterns.The published prediction models were evaluated and modified according to observations in the present study as well as a database of 41 pipe loading tests assembled from the literature.Axial strain measurements of FOSS nerves horizontally installed above the pipeline were correlated with the failure behavior of the overlying soil.The test results indicate that the previous analytical models could be further improved regarding their estimations in the failure geometry and mobilization distance at the peak uplift resistance.For typical slip plane failure forms,inclined shear bands star from the pipe shoulder,instead of the springline,and have not yet reached the ground surface at the peak resistance.The vertical inclination of curved shear bands decreases with increasing uplift displacements at the post-peak periods.At large displacements,the upward movement is confined to the deeper ground,and the slip plane failure progressively changes to the flow-around.The feasibility of FOSS in pipe uplift resistance prediction was validated through the comparison with image analyses.In addition,the shear band locations can be identified using fiber optic strain measurements.Finally,the advantages and limits of the FOSS system are discussed in terms of different levels in upward PSI assessment,including failure identification,location,and quantification. | Haojie Li Honghu Zhu Yuanhai Li Chunxin Zhang Bin Shi | 2022 | Journal of Rock Mechanics and Geotechnical Engineering2022，14，4： | 5 |
| 5 | Restoration of space-variant blurred image based on motion-blurred target segmentation显示文摘In imaging on moving target,it is easy to get spacevariant blurred image.In order to recover the image and gain recognizable target,an approach to recover the space-variant blurred image is presented based on image segmentation.Because of motion blur's convolution process,the pixels of observed image's target and background will be displaced and piled up to produce two superposition regions.As a result,the neighboring pixels in the superposition regions will have similar grey level change.According to the pixel's motion-blur character,the target's blurred edge of superposition region could be detected.Canny operator can be recurred to detect the target edge which parallels the motion blur direction.Then in the segmentation process,the whole target image which has the character of integral convolution between motion blur and real target image can be obtained.At last,the target image is restored by deconvolution algorithms with adding zeros.The restoration result indicates that the approach can effectively solve the kind of problem of space-variant motion blurred image restoration. | Yuye Zhang Xuewei Wang Chunxin Wang | 2010 | Journal of Systems Engineering and Electronics2010，21，2： | 4 |
| 6 | Investigation of water impingement on a multi-element high-lift airfoil by Lagrangian and Eulerian approach显示文摘McDonnell Douglas Aerospace(MDA)high-lift model is widely used in the study of multi-element airfoil,while there is still short knowledge of ice accretion and water impingement on it.In this paper,based on two-phase flow theory,two numerical models were presented by using both Eulerian approach and Lagrangian approach,respectively,in order to predict the water impingement efficiency on a two-dimensional(2D)multi-element high-lift airfoil.Both computational results were validated with the experiment data,which shown good agreements in the impingement limitations and tendency.The trend that how the attack angle and droplet diameter affect the feather of local water impingement characteristics on the different elements of MDA were further investigated.As shown in this research,the trends that the local impingement intensity and extent on flap of MDA varied differently as in general understanding due to the complex structures of flow field,which should be careful cognized in design of the ice protection system. | Chenxing Yu Peng Ke Guangfeng Yu Chunxin Yang | 2015 | Propulsion and Power Research2015，4，3： | 4 |
| 7 | Reexamination of Correlations for Nucleate SiteDistribution on Boiling Surface by Fractal Theory显示文摘Nucleate site distribution plays an essential role in nucleate boiling process. In this paper1 it is pointed out that the size and spatial distribution density of nucleate sites presented on real boiling surface can be described by the normalized fractal distribution function, and the physical meaning of parameters involved in some experimental correlations proposed by early investigations are identified according to fractal distribution function. It is further suggested that the surface micro geometry characteristics such as the shape of cavities should be described and analyzed qualitatively by using fractal theory. | Yang Chunxin(University of Aeronautics and Astronautics, 100083 Beijing, China) | 1997 | Journal of Thermal Science1997，6，2： | 4 |
| 8 | 倾斜油藏二氧化碳驱油中的黏性指进分析显示文摘针对倾斜油藏CO2驱油过程中的黏性指进问题,建立了CO2驱油黏性指进模型,并对其进行了求解。重点分析了CO2的特性、驱油速度、原油黏度、渗透率和沉积韵律对黏性指进的影响。研究结果表明:在驱油过程中,由于CO2的降黏作用,减缓了指进;随着驱油速度的增大,指进程度加重;随着渗透率的增大,指进程度减缓;反韵律地层较正韵律地层的指进程度严重;随着原油黏度的增大,指进程度加重。 | 苏玉亮 吴春新 Su Yuliang Wu Chunxin | 2009 | 石油钻探技术2009，37，5： | 4 |
| 9 | Plasma Modified Polyaramid Fiber Surface and Fiber/Epoxy Interface显示文摘Kevlar-49 fiber was surface-modified through cold air plasma treatment and plasma grafting ofacrylic acid (AA).Fiber surface properties were studied with ESCA,while interface properties with asingle fiber pull-out (SFPO) test.The stated surface modifications evidently improved the interfacialadhesion and increased the interfacial fracture energy of the aramid/epoxy composite system. | Chunxin ZHANG Shijiu JIN Yunzhao YU Institute of Chemistry,Academia Sinica,Beijing 100080,China | 1993 | Journal of Materials Science & Technology1993，9，6： | 4 |
| 10 | Neural plasticity after spinal cord injury显示文摘Plasticity changes of uninjured nerves can result in a novel neural circuit after spinal cord injury, which can restore sensory and motor functions to different degrees. Although processes of neural plasticity have been studied, the mechanism and treatment to effectively improve neural plasticity changes remain controversial. The present study reviewed studies regarding plasticity of the central nervous system and methods for promoting plasticity to improve repair of injured central nerves. The results showed that synaptic reorganization, axonal sprouting, and neurogenesis are critical factors for neural circuit reconstruction. Directed functional exercise, neurotrophic factor and transplantation of nerve-derived and non-nerve-derived tissues and cells can effectively ameliorate functional disturbances caused by spinal cord injury and improve quality of life for patients. | Jian Liu Xiaoyu Yang Lianying Jiang Chunxin Wang Maoguang Yang | 2012 | Neural Regeneration Research2012，7，5： | 4 |
| 11 | Characterization,Evolution and Expression of the Calmodulinl Genes from the Amphioxus Branchiostoma belcheri tsingtauense显示文摘二全身的 cDNAs ,命名 CaM1a 和 CaM1b ,编码高度 conservedcalmodulinl ( CaM1 )蛋白质,从文昌鱼 Branchiostoma belcheritsingtauense.There 的 cDNA 图书馆被孤立仅仅是他们之间的二核苷酸差别,生产 CaMl 的氨基酸顺序的 CaMla 和 CaMlb.Comparison 之间的一氨基酸差别表明 theB.belcheri tsingtauense CaMla 与 B.floridae andB.lanceolatum ,果蝇 melanogaster 凸轮,海鞘类动物 Halocynthia roretzi CaMA 和软体动物 Aplysiacalifornica 凸轮,和 CaMlb 的 CaMl 蛋白质是相同的仅仅在一个位置不同( 138 , Asn 到毒蛇)。种系发生的分析显示在所有三文昌鱼种的 CaMl 看起来编码常规凸轮 andCaMl 可能从 CaMl.Southern 污点的基因复制被导出建议有在 B.belcheri tsingtauense.Northern 污点的染色体并且在 situ 杂交分析 hows 的 CaMl 的二个拷贝二个 CaMl mRNA 抄本的存在与在不同成年纸巾的各种各样的表示层次和在文昌鱼 B.belcheri tsingtauense.The 进化和后生动物的凸轮 mRNA 的差异的胚胎的阶段,抄本也被讨论。 | Jing LUAN Zhenhui LIU Shicui ZHANG Hongyan LI Chunxin FAN Lei LI | 2007 | Acta Biochimica et Biophysica Sinica2007，39，4： | 4 |
| 12 | The investigation of internal solitary waves over a continental shelf-slope显示文摘Internal solitary waves(ISWs)always happen in marginal seas,where stable stratification exists.ISWs may carry large energy when they propagate and affect marine engineering constructions such as marine drilling platforms.Previous studies,including a large number of mooring observations and laboratory experiments,show the speed of ISWs will change when they pass by shelf slopes.Korteweg-de Vries(KdV)theory explain this phenomenon.In the paper,we use a laboratory experiment and a numerical model experiment to verify this theory.In the laboratory experiment,we injected two layers of water of different densities in a tank to simulate marine stratification and make ISWs.We use a CCD camera to record the whole process.The camera can take 16 photos per second.In the numerical experiment,we input the same original conditions as the laboratory one.The results of 18 different original conditions show the dimensionless factorδplays a key role in deciding the amplitudes and shapes of ISWs.The main conclusion also contains that small-amplitude waves match well with KdV theory while mKdV is better for largeamplitude waves.Whether the laboratory experiment or numerical experiment shows results with a high agreement.In future studies,we may use a numerical model with higher resolution to get analysis about phase speed and energy of ISWs. | MA Qian YUAN Chunxin LIN Xiaopei CHEN Xue’en | 2020 | Journal of Oceanology and Limnology2020，38，3： | 3 |
| 13 | The effect of ownership on the prudential behavior of banks – The case of China显示文摘 | Chunxin Jia | 2007 | Journal of Banking and Finance2007，，1： | 3 |
| 14 | A numerical study of generation and propagation of type-a and type-b internal solitary waves in the northern South China Sea显示文摘Numerical simulations based on a high-resolution three-dimensional MIT general circulation model(MITgcm)using realistic topography and tidal forcing are conducted to investigate the generation and propagation of the so-called type-a waves(large-amplitude rank-ordered wave packets)and type-b waves(isolated wave packets)in the northern South China Sea.At first,we summarized and analyzed the generation and propagation characteristics of these waves.Then,energy budget at the Luzon Strait is calculated.Energy generation has three local maxima every day,of which the largest one corresponds to the emergence of the type-a wave.Energy flux at the west boundary of the Luzon Strait shows two local maxima each day.The larger one is consistent with the generation of the type-a wave and the smaller one is in correspondence with the generation of the type-b wave.Sensitivity experiments are designed to explore the role of the east and west ridge of the Luzon Strait on the generation and propagation of the type-a and type-b waves.It is found that the east ridge is indispensable on the generation of the type-a wave while the west ridge has little contribution.The west ridge diminishes the type-a waves'amplitude but hardly changes their propagation speed.The type-b waves also come from perturbation signals which originate from the east ridge and are enhanced in amplitude and reduced in propagation speed by the west ridge. | Zhi Zeng Xueen Chen Chunxin Yuan Shengquan Tang Lequan Chi | 2019 | Acta Oceanologica Sinica2019，38，11： | 2 |
| 15 | Use of electrosense in the feeding behavior of sturgeons显示文摘The electro-receptive lateral line system appeared early in the evolutionary history of fish.Sturgeons,members of the primitive Chondrostei group,are known for their electroreceptors(ampullae of Lorenzini)on the head,which are thought to be sensitive to weak electric fields in aquatic environments and involved in feeding,mating and migration.Here,we report the results of a set of behavioral and electrophysiological experiments designed to determine the function and characteristics of the electrosense in cultured sturgeons.The results showed Sibe-rian sturgeon(Acipenser baerii Brandt,1869)feeding striking at bio-electric fields produced by living feed-fish enclosed in a gel chamber and at the corrosion field produced by metal rods.With an electric stimulus that mim-ics the bio-electric fields produced by living prey,the relative discharge rate of electrosensory neurons in the dorsal octavolateralis nucleus(DON)was modulated by and phase-locked to sinusoidal stimulus and some units showed selectivity for dipolar direction in white sturgeon(Acipenser transmontanus Richardson,1836).This is the first study to provide the empirical evidence correlating with electrosensory behaviors and electrophysiolog-ical responses in cultured sturgeons,and suggesting that electrosense does play an innate role in feeding behav-ior of sturgeon.We believe this will have important implications for protecting sturgeons in the wild. | Xuguang ZHANG Jiakun SONG Chunxin FAN Hongyi GUO Xiaojie WANG Horst BLECKMANN | 2012 | Integrative Zoology2012，7，1： | 2 |
| 16 | An international multicentric phaseⅢrandomized controlled trial of time-acupoints-space acupuncture for the prevention of chemotherapy-induced fatigue in patients with early stage breast cancer:a study protocol显示文摘OBJECTIVE:To determine the difference in prevention of chemotherapy-induced fatigue between time-acupointsspace acupuncture(ATAS)administered weekly compared to sham acupuncture and non-acupuncture in patients with early breast cancer receiving adjuvant chemotherapy by epirubicine-cyclophosphamide(EC)followed by paclitaxel,as measured by the multidimensional fatigue inventory(MFI)over the previous week and Visual Analogue Scale measuring fatigue(VAS-F),and to evaluate the effects of ATAS on selfreported neuropathy pain,sleep,anxiety and depression.METHODS:In this multicenter clinical trial,we have randomized patients into 3 groups:ATAS,Sham and nonacupuncture with an unequal randomization of 2∶1∶1.A cloud related electronical clinical report form and smartphone platform was established for data entry.Patients with a history of stageⅠ-Ⅲbreast cancer scheduled to receive adjuvant chemotherapy.Acupuncture will be delivered once a week during chemotherapy with VAS-F evaluation.In order to qualify and quantify the mechanism of fatigue induced by chemotherapy with or without acupuncture,an evaluation of immune profiling was incorporate in this study.RESULTS:The presence and seriousness of chemotherapy-induced fatigue should be considered in therapeutic programs for early breast cancer treatment.Fatigue induced by adjuvant chemotherapy in patients with breast cancer remains a major concern affecting the quality of life significantly.Unfortunately,we do not have effective pharmacological interventions yet.And clinical trials of acupuncture in preventing chemotherapyinduced fatigue in patients with early breast cancer have not been reported.CONCLUSION:The findings of the trial will allow us to determine the effects of acupuncture treatment approach.We will also be able to confirm whether ATAS is better than sham acupuncture and non-acupuncture treatments. | Saghachian Mahasti Barry Caroline Asselain Bernard LI Yunfen NIE Jianyun LIU Dequan CHEN Dedian CHEN Chunxin Laura Estevez LI Wenhui Jean-Pierre Armand ZHU Miansheng JU Liya | 2022 | Journal of Traditional Chinese Medicine2022，42，2： | 2 |
| 17 | Bcl-x L Retrotranslocates Bax from the Mitochondria into the Cytosol显示文摘 | Frank Edlich Soojay Banerjee Motoshi Suzuki Megan M. Cleland Damien Arnoult Chunxin Wang Albert Neutzner Nico Tjandra Richard J. Youle | 2011 | Cell2011，，1： | 2 |
| 18 | The effect of ownership on the prudential behavior of banks – The case of China显示文摘 | Chunxin Jia | 2007 | Journal of Banking and Finance2007，，1： | 1 |
| 19 | Drop dis- tributions and numerical simulation of dropwise condensa- tion heat transfer 显示文摘 | WU Yuting YANG Chunxin YUAN Xiugan | 2001 | International Journal of Heat and Mass Transfer2001，44，23： | 1 |
| 20 | Robust object tracking with adaptive fusion of color and edge strength lo- cal mean features based on oarticle fiber显示文摘 | LI Chunxin Wang Xiaotong Xu Xiaogang | 2009 | IEEE Imer- national Forum on Information Technology and Applica- tions ( S7695 - 3600)2009，10，： | 1 |
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