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| 1 | Hydrophobic modification of poly(phthalazinone ether sulfone ketone) hollow fiber membrane for vacuum membrane distillation显示文摘新恐水病(phthalazinone 醚 sulfone 酉同类)(PPESK ) poly,空心丝复合膜被表面涂的修正方法获得。 | Zhao Jin Da Ling Yang Shou Hai Zhang Xi Gao Jian | 2008 | Chinese Chemical Letters2008，19，3： | 5 |
| 2 | CDH13 Genetic Polymorphisms, Adiponectin and Ischemic Stroke: a Chinese Family-based Sib-pair Study显示文摘Objective To understand the relationships between CDH13(T-cadherin) genetic polymorphisms, adiponectin levels and ischemic stroke, and possible interactions between CDH13 polymorphisms and other risk factors. Methods We recruited 342 Chinese ischemic stroke sib pairs. We genotyped rs4783244 and rs7193788 on CDH13 using time-of-flight mass spectrometry genotyping technology and measured total and high-molecular weight(HMW) adiponectin levels. We investigated associations between SNPs and ischemic stroke, and interactions between SNPs and other risk factors using multi-level mixed-effects regression model. Results In individuals without ischemic stroke, CDH13 rs4783244 was associated with total adiponectin levels(per T: Coef =-0.257, P = 0.001). CDH13 rs7193788 was associated with total adiponectin levels(per A: Coef =-0.221, P = 0.001) and HMW adiponectin levels(per A: Coef =-0.163, P = 0.003). rs7193788 was significantly associated with ischemic stroke(GA/AA vs. GG: OR = 1.55, 95% CI: 1.07 to 2.24, P = 0.020) after Bonferroni correction(α = 0.025). There was an interaction between rs7193788 and diabetes(P = 0.036). Compared to diabetes-free individuals with rs7193788 GG genotype, diabetes patients with rs7193788 GA/AA genotypes had higher risks for ischemic stroke(OR = 2.64, 95% CI: 1.58-4.40, P < 0.001). Conclusion CDH13 genetic polymorphisms are associated with adiponectin levels and ischemic stroke. An interaction is found between CDH13 SNP and diabetes for ischemic stroke. | CHEN Li SUN Ke Xin JUAN Juan FANG Kai LIU Kuo WANG Xue Yin WANG Ling YANG Chao LIU Xiao Qiang LI Jing TANG Xun WU Yi Qun QIN Xue Ying WU Tao CHEN Da Fang HU Yong Hua | 2017 | Biomedical and Environmental Sciences2017，30，1： | 4 |
| 3 | Hepatic encephalopathy complicated with hyponatremia and acid-base disturbance and its prognosis显示文摘Objective:To improve the diagnosis and therapeutic effect of occurrence and development of hyponatremia and disorder of acid-base balance among patients with hepatic encephalopathy(HE) by elucidating the regularity and mechanism,as well as its influence on prognosis.Methods:327 HE patients admitted to our hospital from January 1990 to June 2010 were enrolled.Meanwhile 316 patients hospitalized in the medical department of the same hospital were chosen as the control group.Patients in both groups were given the same methods to measure arterial blood gas parameters(pH value,PaCO2,[HCO3-],TCO2,BE and SaO2),blood biochemistry([Na+],[K+],[Cl-]),liver function,kidney function and blood glucose,serum sodium,and thereupon tocalculate the anion gap(AG) and the potential [HCO3-],and acid-base balance disorder.Results:Among the 327 HE patients,hyponatremia was found in 188 cases(57.4%),of whom 132 patients died(70.2%).While among the 316 patients in control group,68 presented with hyponatremia(21.5%),and 19 died(27.9%).The incidence and mortality were significantly different between the two groups(P<0.001).All the 327 patients presented with different degrees of acid-base balance disorder and 178 died(54.4%),in whom 164(50.2%) belonged to simple acid-base balance disorder and 74(45.1%) died,136(41.6%) were dual acid-base balance disorder and 80(58.8%) died,27(8.2%) were triple acid-base disturbance and 24(88.9%) died.Whereas in the control group only 83 patients(26.2%) were recognized as simple and dual acid-base balance disorder,and 18(21.7%) died.There was higher incidence of acid-base balance disorder and mortality rate in HE group than control one(P<0.001).Conclusion:Hyponatremia is valuable to judge HE patients' prognosis.The key parameters in the judgment and evaluation on acid-base balance disorder among HE patients are the change of pH values and serum electrolyte values.When pH value ≤ 7.30 or > 7.55,it generally suggests a poor prognosis. | Ren Chengshan Wang Lei Zhao Xiaoyan Yang Shiming Zhang Yanqi Wang Xiwen Bo Jianying Zhang Pengbin Guo Hong Ling Xianlong Li Yihui Da Siping Xie Xia Ren Wei Li Chunhua Qian Guisheng | 2012 | Journal of Medical Colleges of PLA(China)2012，27，3： | 3 |
| 4 | Synthesis and anti-TMV activity of novel N-(3-alkyl-1H-pyrazol-4-yl)-3-alkyl-4-substituted-1H-pyrazole-5-carboxamides显示文摘In order to investigate the biological activity of novel bis-pyrazole compounds,a series of N-(3-alkyl-5-(N-methylcarbamyl)- 1H-pyrazol-4-yl)-3-alkyl-4-substituted-1H-pyrazole-5-carboxamides were designed and synthesized with ethyl 3-alkyl-1H-pyrazole -5-carboxylate 1 as starting materials.N-Methyl-3-alkyl-4-amino-1H-pyrazole-5-carboxamides 6 were obtained from 1 via 5 steps.3-Alkyl-4-substitued-1H-pyrazole-5-carboxyl chlorides 4a,4b,11a,11b,11c or 12 were also obtained from 1 via several steps.Target compounds 7a-7g were obtained after the reaction of 6 with the above 1H-pyrazole-5-carboxyl chlorides.Preliminary bioassay showed some compounds possessing good inactivation effect against TMV(tobacco mosaic virus).Compound 7a showed higher activity superior to ningnanmycin at a concentration of 5.0×10^(-4) g/mL and equal activity at 1.0×10^(-4) g/mL;7b and 7c showed equal activity to virazole both at concentrations of 5.0×10^(-4) g/mL and 1.0×10^(-4) g/mL. | Da Qiang Zhang Gao Fei Xu Zhi Jin Fan Dao Quan Wang Xin Ling Yang De Kai Yuan | 2012 | Chinese Chemical Letters2012，23，6： | 3 |
| 5 | First total synthesis of a naturally occurring nucleoside disulfide:9-(5'-Deoxy-5'-thio-β-D-xylofuranosyl)adenine disulfide显示文摘A naturally occurring nucleoside disulfide,9-(5'-deoxy-5'-thio-β-D-xylofuranosyl)adenine disulfide,was first synthesized from D-xylose over 7 steps in 20%overall yield.The key step involved Vorbriiggen glycosylation of silylated N^6-benzoyladenine with xylose diacetate moiety. | Hai Xin Ding Ling Cui Da Ru Chun Yang Ban Peng Cao Qi Sun Qiang Xiao | 2012 | Chinese Chemical Letters2012，23，9： | 2 |
| 6 | Removal of 2,4-dichlorophenol from wasterwater by vacuum membrane distillation using hydrophobic PPESK hollow hiber membrane显示文摘2,4-Dichlorophenol 从 waster 水被移开用一新恐水病(phthalazinone 醚 sulfone 酉同类)(PPESK ) poly 凹陷由真空膜蒸馏(VMD ) 的纤维膜。 | Zhao Jin Da Ling Yang Shou Hai Zhang Xi Gao Jian | 2007 | Chinese Chemical Letters2007，18，12： | 2 |
| 7 | Synthesis and anti-TMV activity of novel N-(pyrimidin-5-yl)-N'-phenylureas显示文摘In order to find novel leading structures of pesticide,a series of N-(pyrimidin-5-yl)-N'-phenylureas(4a-4h) were designed and synthesized from 4-chloro-2-diethylamino-6-methyl-5-nitropyrimidine 1 via substitution,reduction and acylation procedures. Preliminary bioassay showed that all the target compounds processing good anti-TMV(tobacco mosaic virus) activity.Two compounds(4d and 4e) displayed higher activity superior to virazole at a concentration of 5.0×10^(-4)g/mL. | De Kai Yuan Da Qiang Zhang Ru Xing Li Dao Quan Wang Xin Ling Yang | 2011 | Chinese Chemical Letters2011，22，1： | 2 |
| 8 | The ob- servations of basal cell carcinoma by dermoscopy 显示文摘 | Yang Da Ling Muzheng Tu Tianzheye | 1998 | Japanese Journal of Skin Pathological Histology1998，108，10： | 1 |
| 9 | 17-Dehydroxyholothurin A, a New Sulfated Triterpene Glycoside from Sea Cucumber Holothuna impatiens显示文摘A new sulfated triterpene glycoside named as 17-dehydroxyholothurin A 1 was isolated from the sea cucumber Holothuria impatiens. Its structure was elucidated on the basis of spectroscopic data (2D NMR and MS) and chemical evidence. Compound 1 showed cytotoxic activity against cancer cell lines MKN-28, MFC-7, KB, HL-60 and Hep G2 with IC50 values of 1.98, 4.53, 2.01, 4.69 and 2.80×10-6 mol/L, respectively. | Peng SUN Yang Hua YI Ling LI Min GUI Hai Feng TANG Da Zhi ZHANG Shi Long ZHANG | 2006 | Chinese Chemical Letters2006，17，11： | 1 |
| 10 | Transcriptional and Post-transcriptional Modulation of SQU and KEW Activities in the Control of Dorsal-Ventral Asymmetric Flower Development in Lotus japonicus显示文摘在 Papilionoideae 荚,莲花 japonicus,发展背面腹(DV ) 不对称的花被二 TB1/CYCLOIDEA/PCF (TCP ) 基因,摆平的标准(SQU ) 和翻身翅膀主要在莲花(英国伦敦郊外的村名) 控制,它分别地决定背面、侧面的身份。然而,这二高度相应的基因怎么安排他们的多样的功能的分子的基础仍然保持不清楚。这里,我们分析了他们的表示层次,并且调查了 SQU 和英国伦敦郊外的村名的 transcriptional 活动。我们证明 SQU 拥有激活和压抑活动,当英国伦敦郊外的村名仅仅充当使活跃之物时。他们形成人 -- 并且 heterodimers,然后联合地在抄写水平调整他们的表示。而且,我们识别了 post-transcriptional 修正, phosphorylation 和 ATP/GTP 绑定的二种类型,哪个能影响他们的 transcriptional 活动。在 SQU 和英国伦敦郊外的村名的 ATP/GTP 有约束力的主题的变化导致忍受变异的蛋白质显示器有缺陷者 DV 不对称的花开发的 phosphorylation,和转基因的植物的失败,显示二结合修正为他们的多样的函数是必要的。总的来说, SQU 和英国伦敦郊外的村名活动精确在抄写和抄写以后的层次被调制,它可能连接 DV 不对称的花开发到不同生理的地位或发信号的小径。 | Zhiyong xu Kai Cheng Xin Li Jun Yang Shilei Xu Xiangling Cao Xiaohe Hu Wei Xie Ling Yuan Mike Ambrose Genyun Chen Hualing Mi Da Luo | 2016 | Molecular Plant2016，9，5： | 1 |
| 11 | Molecular evolution of paclitaxel biosynthetic genes TS and DBAT of Taxus species显示文摘 | Da Cheng Hao Ling Yang Beili Huang | 2009 | Genetica2009，，2： | 1 |
| 12 | Synthesis of polypiperazine-amide thin-film membrane on PPESK hollow fiber UF membrane显示文摘一个新界面聚合(IP ) 过程被开发以便综合 polypiperazine 酰胺内部表面上的薄电影的膜 poly (phthalazinone 醚 sulfone 酉同类)(PPESK ) 空心丝极端过滤(UF ) 膜。有好性能的空心丝复合膜被英尺红外和扫描电子显微检查法准备并且学习。 | Fa Jie Yang Da Ling Yang Shou Hai Zhang Xi Gao Jian | 2007 | Chinese Chemical Letters2007，18，8： | 0 |
| 13 | The facile synthetic method of 5-hydroxymethyluracil显示文摘为 5-hydroxymethyluracil 的准备的一个实际、工业的过程被开发了。这个方法有灵巧的操作,低费用和稳定的产量的优点。 | Ling Qiang Kong Jin Zhao Li Fan Da Cheng Yang | 2009 | Chinese Chemical Letters2009，20，3： | 0 |
| 14 | The Uptake and Distribution Evidence of Nano-and Microplastics in vivo after a Single High Dose of Oral Exposure显示文摘Objective Tissue uptake and distribution of nano-/microplastics was studied at a single high dose by gavage in vivo.Methods Fluorescent microspheres(100 nm,3μm,and 10μm)were given once at a dose of 200 mg/(kg∙body weight).The fluorescence intensity(FI)in observed organs was measured using the IVIS Spectrum at 0.5,1,2,and 4 h after administration.Histopathology was performed to corroborate these findings.Results In the 100 nm group,the FI of the stomach and small intestine were highest at 0.5 h,and the FI of the large intestine,excrement,lung,kidney,liver,and skeletal muscles were highest at 4 h compared with the control group(P<0.05).In the 3μm group,the FI only increased in the lung at 2 h(P<0.05).In the 10μm group,the FI increased in the large intestine and excrement at 2 h,and in the kidney at 4 h(P<0.05).The presence of nano-/microplastics in tissues was further verified by histopathology.The peak time of nanoplastic absorption in blood was confirmed.Conclusion Nanoplastics translocated rapidly to observed organs/tissues through blood circulation;however,only small amounts of MPs could penetrate the organs. | HONG Tao SUN Wei DENG Yuan LYU Jian Da JIN Cui Hong BAI Ying Long NA Jun ZHANG Rui GAO Yuan PAN Guo Wei YANG Zuo Sen YAN Ling Jun | 2024 | Biomedical and Environmental Sciences2024，37，1： | 0 |
| 15 | Prenatal Hypoxia Altered Angiotensin Ⅱ-mediated Vasoconstrictions via PKC/ERK/ROCK Pathways and Potassium Channels in Rat Offsrping Middle Cerebral Artery显示文摘Adverse environmental factors or prenatal insults may cause developmental and pathological changes in the brain[1].Previous studies showed that a number of unfavorable prenatal factors might trigger the pathological changes of adult diseases such as hypertension and diabetes mellitus[2].It is rational that inner-utero hypoxia could be a common problem of prenatal insults-induced development. | LI Da Wei BO Lel TU Qing ZHOU An Wen SHI Lin Ling YANG Xiao Jun MAO Cai Ping | 2021 | Biomedical and Environmental Sciences2021，34，3： | 0 |
| 16 | Development of a pressure coring system for the investigation of deep underground exploration显示文摘To provide a more accurate evaluation of the scale of deep underground resources,a new pressure coring system was carefully developed and its strength and safety of the engineering were verified by theoretical analyses and numerical simulation.The designed pressure coring system can obtain cores with length of 3 m and diameter of 50 mm at 70 MPa.The results of the ball-drop operation experiment demonstrate that differential motion assembly can effectively cut a safety pin by applying a tensile force of 4852 N,and it can lift the core tube through the center pole to complete a series of mechanical actions to seal the pressure.Additionally,by maintaining pressures at 70 MPa for 30 min,the pressure sealing capacity of the system was proven.Furthermore,a core sample with a diameter of 50 mm was obtained through a core drilling experiment and the coring performance of the pressure coring system was verified.This study can not only enrich the existing onshore coring technology but also provide a theoretical guide and design criteria for the development of similar pressure coring systems to meet the demand for deeper underground exploration. | Da Guo Ling Chen Zhongya Zhou Dingming Wang Yiwei Zhang Xun Yang Xin Fang Xiaojun Wang Heping Lu Lin Dai Heping Xie | 2023 | International Journal of Mining Science and Technology2023，33，11： | 0 |
| 17 | CACA Guidelines for Holistic Integrative Management of Breast Cancer显示文摘Purpose:Breast cancer is now the most common malignant tumor worldwide.About one-fourth of female cancer patients all over the world sufer from breast cancer.And about one in six female cancer deaths worldwide is caused by breast cancer.In terms of absolute numbers of cases and deaths,China ranks frst in the world.The CACA Guidelines for Holistic Integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in China.Methods:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and consensus.Results:The CACA Guidelines for Holistic Integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer patients.Conclusion:We to standardize the diagnosis and treatment of breast cancer in China through the formulation of the CACA Guidelines. | Jiong Wu Daiming Fan Zhimin Shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang Shusen Wang Xiaojia Wang Shu Wang Haibo Wang Tao Wang Xiang Wang Jing Wang Jia Wang Biyun Wang Li Fu Hongyuan Li Yehui Shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu Qiang Liu Qiang Sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui Song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping Shen Zhenzhou Shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan Sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer Society,Chinese Anti-Cancer Association | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
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