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| 1 | Palaeogeomorphology and its control on the development of sequence stratigraphy and depositional systems of the Early Silurian in the Tarim Basin显示文摘The Silurian in the Tarim Basin was deposited on the basement deformed by the Caledonian tectonic movements at the end of the Late Ordovician. The development and distribution of sedimentary sequences of the Early Silurian have been clearly controlled by the palaeogeomorphology of the Late Ordovician. Based on unconformity characteristics and distribution of erosion, several zones can be differentiated including a high uplifted erosion zone, a transitional slope zone and a depression zone. The central and west Tabei Uplift zones show high angular unconformity and intense erosion. The Tarim Basin in the late Ordovician shows characteristics of higher in the west, lower in the east while higher in the south, lower in the north. The Early Silurian mainly developed transgressive and highstand systems tracts on the whole, while the lowstand systems tract only developed partly below the slope break. The palaeogeomorphology controlled the clastic source supply and deposit distribution. Braided delta system and tidal flat–estuary system were deposited. The duration of uplifting of the Tazhong paleouplift was longer than that of the Tabei paleo-uplift, and deposition was later. This led to the lower and middle members of the Kepingtage Formation missing in that area. As a large-scale transgression occurred during the deposition period of the upper member of the Kepingtage Formation, sediment from the west of the basin was transported and deposited by tides and waves, forming tidal–marine debris systems above the uplift. Proximal alluvial fan and fan delta coarse clastic deposits developed in proximal uplift zone in the east and southeast of the basin, and braided delta put forward to the transitional zone between the edge of uplift and the sea. Large-scale tidal channel, sub-distributary channel and mouth bar of the delta front can form favorable reservoirs, and they are primary targets for oil and gas exploration. This research on sequence–depositional systems development and distribution controlled by palaeogeomorphology is significant in guiding the prediction of reservoir sandstones. | Liu Jingyan Lin Changsong Cai Zhenzhong Zhu Yongfeng Yang Yongheng Peng Li Si Baoling Huang Zhen Li Huanpu Xu Yingcai Su Zhenzhen | 2010 | Petroleum Science2010，7，3： | 13 |
| 2 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 3 | A 2-kb Mycovirus Converts a Pathogenic Fungus into a Beneficial Endophyte for Brassica Protection and Yield Enhancement显示文摘Mycoviruses are viruses that infect fungi,and hypovirulence-associated mycoviruses have the potential to control fungal diseases.However,it is unclear how mycovirus-mediated hypovirulent strains live and survive in the field,and no mycovirus has been applied for field crop protection.In this study,we found that a previously identified small DNA mycovirus(SsHADV-1)can convert its host,Sclerotinia sclerotiorum,from a typical necrotrophic pathogen to a beneficial endophytic fungus.SsHADV-1 downregulates the expression of key pathogenicity factor genes in S.sclerotiorum during infection.When growing in rapeseed,the SsHADV-1-infected strain DT-8 significantly regulates the expression of rapeseed genes involved in defense,hormone signaling,and circadian rhythm pathways.As a result,plant growth is promoted and disease resistance is enhanced.Field experiments showed that spraying DT-8 at the early flowering stage can reduce the disease severity of rapeseed stem rot by 67.6%and improve yield by 14.9%.Moreover,we discovered that SsHADV-1 could also infect other S.sclerotiorum strains on DT-8-inoculated plants and that DT-8 could be recovered from dead plants.These findings suggest that the mycoviruses may have the ability to shape the origin of endophytism.Our discoveries suggest that mycoviruses may influence the origin of endophytism and may also offer a novel strategy for disease control in which mycovirus-infected strains are used to improve crop health and release mycoviruses into the field. | Hongxiang Zhang Jiatao Xie Yanping Fu Jiasen Cheng Zheng Qu Zhenzhen Zhao Shufen Cheng Tao Chen Bo Li Qianqian Wang Xinqiang Liu Binnian Tian David B.Collinge Daohong Jiang | 2020 | Molecular Plant2020，13，10： | 9 |
| 4 | Expression and significance of fat mass and obesity associated gene and forkhead transcription factor O1 in non-alcoholic fatty liver disease显示文摘 | Zhang Jielei Li Shan Li Jingyi Han Chao Wang Zhifang Li Chong Wang Xiaoman Liu Zhenzhen Wen Jianguo Zheng Lili | 2014 | Chinese Medical Journal2014，，21： | 9 |
| 5 | Study on patterns and chemical features of NO effect on marine phytoplankton growth显示文摘This article discusses the patterns of NO effect on marine phytoplankton growth from chemical perspective.The experimental results of four algae,which are Platymonas hal-golandica var.tsingtaoensis,Platymonas subcordiformis,Skeletonema costatum and Nitzschia closterium farma minutissima,are as follows:(i) In f/2 medium or f/50 medium,the growth of these four algae was obviously promoted or inhibited when nitric oxide of different concentrations was added once or twice each day during the cultivation;(ii) The NO effects on the growth of marine phytoplankton are in normal distribution.Different phytoplankton has different optimum NO concentration,which is consistent with the influence of NO on the growth of high plants;(iii) The effect of NO on Platymonas halgolandica var.tsingtaoensi,which is a food alga,is different from that on the red tide algae Skeletonema costatum and Nitzschia closterium farma minutis-sima.The authors put forward a new opinion that every alga has its own NO threshold concen-tration.All the above results may provide new clues to understand the formation of red tide. | ZHANG Zhengbin LIN Cai LIU Chunying XING Lei WU Zhenzhen SUN Feng | 2005 | Science China Chemistry2005，48，4： | 9 |
| 6 | Synergistic effects of elevated homocysteine level and abnormal blood lipids on the onset of stroke显示文摘Hyperhomocysteinemia and abnormal blood lipids are independent risk factors for stroke.However,whether both factors exert a synergistic effect in the onset of stroke remains unclear.The present study is a retrospective analysis of 2 089 cases of stroke and 2 089 control cases of simple intervertebral disk protrusion using a paired multivariate logistic regression method.Adjusting for known confounding variables including the patients’age,gender,smoking status,alcohol consumption status,patient and family medical history,and clinical biochemical indices,elevated homocysteine level was related to the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids showed a 40.9%increase in the risk for stroke compared to patients with normal homocysteine levels and blood lipids(odds ratio 1.409;95%confidence interval1.127–1.761).These results indicate that elevated homocysteine and abnormal blood lipids exert synergistic effects in the onset of stroke.Patients with elevated homocysteine levels and abnormal blood lipids are predisposed to stroke. | Lu Hao Liming Chen Xiaoyong Sai Zhefeng Liu Guang Yang Rongzeng Yan Lili Wang Caiyun Fu Xuan Xu Zhenzhen Cheng Qiang Wu Shuzhang Li | 2013 | Neural Regeneration Research2013，8，31： | 9 |
| 7 | Heavy Oil and Oil Sands:Global Distribution and Resource Assessment显示文摘Global recoverable resources of heavy oil and oil sands have been assessed by CNPC using a geology-based assessment method combined with the traditional volumetric method, spatial interpolation method, parametric-probability method etc. The most favourable areas for exploration have been selected in accordance with a comprehensive scoring system. The results show:(1) For geological resources, CNPC estimate 991.18 billion tonnes of heavy oil and 501.26 billion tonnes of oil sands globally, of which technically recoverable resources of heavy oil and oil sands comprise 126.74 billion tonnes and 64.13 billion tonnes respectively. More than 80% of the resources occur within Tertiary and Cretaceous reservoirs distributed across 69 heavy oil basins and 32 oil sands basins. 99% of recoverable resources of heavy oil and oil sands occur within foreland basins, passive continental-margin basins and cratonic basins.(2) Since residual hydrocarbon resources remain following large-scale hydrocarbon migration and destruction, heavy oil and oil sands are characterized most commonly by late hydrocarbon accumulation, the same basin types and source-reservoir conditions as for conventional hydrocarbon resources, shallow burial depth and stratabound reservoirs.(3) Three accumulation models are recognised, depending on basin type: degradation along slope; destruction by uplift; and migration along faults.(4) In addition to mature exploration regions such as Canada and Venezuela, the Volga-Ural Basin and the Pre-Caspian Basin are less well-explored and have good potential for oil-sand discoveries, and it is predicted that the Middle East will be an important region for heavy oil development. | LIU Zuodong WANG Hongjun Graham BLACKBOURN MA Feng HE Zhengjun WEN Zhixing WANG Zhaoming YANG Zi LUAN Tiansi WU Zhenzhen | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 9 |
| 8 | Laser Ablation ICP-MS U-Pb Zircon Geochronology of Granitoids and Quartz Veins in the Shihu Gold Mine, Taihang Orogen, North China: Timing of Gold-mineralization and Tectonic Implications显示文摘The Shihu gold deposit, situated in the Taihang Mesozoic orogen of the North China Craton (NCC), is hosted by ductile-brittle faults within Archean metamorphic core complex. The deposit is characterized by gold-bearing quartz-polymetallic sulfides veins. The Mapeng granitoids stock and intermediate-basic dikes intruded the metamorphic basement rocks, and are spatially related to gold mineralization. Detailed laser ablation inductively coupled plasma mass spectrometry (LA ICP-MS) U- Pb zircon ages of the granitic rocks, dykes and mineralized quartz veins in the studied area reveal its magmatic and mineralized history. The mineralized quartz veins contain inherited zircons with ages of about 2.55 Ga and 1.84 Ga, probably coming from the basement. These two Precambrian events are coeval with those in other parts of the NCC. The Mapeng granitoid stock, the largest intrusion in the area, was emplaced at ca. 130 Ma, and is coeval with magmatic zircon populations from diorites and quartz diorite pophyrites in the same region. The ca. 130 Ma magmatism and gold mineralization were most likely related to an underplating event that took place in the Taihang orogen at Late Mesozoic. The timing of gold mineralization with respect to felsic magmatism in the area is similar to those observed in other major gold-producing provinces in the NCC. This episode is simultaneous with those in the eastern margin of NCC, indicative of a widespread late Yanshanian metallogenic event that was a response to the Early Cretaceous lithosphere in the eastern NCC, in which the mesothermal gold deposits were formed from similar tectono-magmatic environments. | CAO Ye LI Shengrong XIONG Xianxiao LI Zhenzhen LIU Xiaobin YAO Meijuan ZHANG Huafeng | 2012 | Acta Geologica Sinica(English Edition)2012，86，5： | 8 |
| 9 | Genetic variants in RAN, DICER and HIWI of microRNA biogenesis genes and risk of cervical carcinoma in a Chinese population显示文摘Objective:Recent evidence indicates that dysregulation of microRNA(miRNA)biogenesis is implicated in cancer development and progression.Based on the important role of miRNA biogenesis genes in carcinogenesis,we hypothesized that genetic variations of the miRNA biogenesis genes may modulate susceptibility to cervical cancer.Methods:We identified three single nucleotide polymorphisms(SNPs)located in the 3'-untranslated regions(3'-UTR)of of miRNA biogenesis key genes(rs1057035 in DICER,rs3803012 in RAN and rs10773771 in HIWI)and genotyped these SNPs in a case-control study of 1,486 cervical cancer cases and1,549 cancer-free controls in Chinese women.Results:Logistic regression analyses showed that no significant associations were observed between the three SNPs and cervical cancer risk[rs3803012 in RAN AG/GG vs.AA adjusted OR=1.104,95%confidence interval(CI):0.859-1.419;rs1057035 in DICER CT/CC vs.TT adjusted OR=0.962,95%CI:0.805-1.149;rs10773771 in HIWI CT/CC vs.TT adjusted OR=0.963,95%CI:0.826-1.122].Conclusions:The findings did not suggest that genetic variants in the 3'-UTR of RAN,DICER and HIWI of miRNA biogenesis genes were associated with the risk of cervical cancer in this Chinese population. | Jiaping Chen Zhenzhen Qin Shandong Pan Jie Jiang Li Liu Jibin Liu Xiaojun Chen Zhibin Hu Hongbing Shen | 2013 | Chinese Journal of Cancer Research2013，25，5： | 8 |
| 10 | The U-Pb chronologic evidence and sedimentary responses of Silurian tectonic activities at northeastern margin of Tarim Basin显示文摘U-Pb ages of Devonian detrital zircons from Tabei Uplift have been determined through LA-ICP-MS test technology.The results revealed that most zircon ages concentrate on 460-414 Ma,especially around 436-423 Ma,indicating possible occurrences of strong tectonic events at the northern margin of Tarim Basin during that period.Combined with previous researches on the basin marginal orogenic belts,intense tectonic activities developed at the northeast margin of Tarim Basin and its obvious sedimentary responses in basin during the end of Ordovician to Early-Middle Silurian are discussed.These include(1) several unconformities within the Late Ordovician-Silurian,showing truncation,erosion,and onlap characteristics,which reflected the local uplift formed during the surrounding extrusion process;(2) the Silurian fluvial delta system from northeast to southwest in Keping,Yingmaili,Hade,and Caohu areas,which reflected the partial uplift at the northeast margin and provided clastic supply to basin;and(3) as indicated by heavy mineral analysis,the Silurian sediments came mainly from the recycles of orogenic belts provenance,which indicated the compress tectonic setting.In addition,a wide range of red mudstone layer distribution in the upper part of the Silurian may be closely related to the surrounding tectonic uplift and the rapid decline of sea levels. | LIU JingYan YANG HaiJun YANG YongHeng CAI ZhenZhong LIU YongQuan RUI ZhiFeng SU ZhenZhen | 2012 | Science China Earth Sciences2012，55，9： | 7 |
| 11 | Activity and hydrothermal stability of CeO_2–ZrO_2–WO_3 for the selective catalytic reduction of NO_x with NH_3显示文摘A series of CeO_2–ZrO_2–WO_3(CZW)catalysts prepared by a hydrothermal synthesis method showed excellent catalytic activity for selective catalytic reduction(SCR)of NO with NH_3 over a wide temperature of 150–550°C.The effect of hydrothermal treatment of CZW catalysts on SCR activity was investigated in the presence of 10% H_2O.The fresh catalyst showed above 90% NO_x conversion at 201–459°C,which is applicable to diesel exhaust NO_x purification(200–440°C).The SCR activity results indicated that hydrothermal aging decreased the SCR activity of CZW at low temperatures(below 300°C),while the activity was notably enhanced at high temperature(above 450°C).The aged CZW catalyst(hydrothermal aging at 700°C for 8 hr)showed almost 80% NO_x conversion at 229–550°C,while the V_2O_5–WO_3/TiO_2 catalyst presented above 80% NO_x conversion at 308–370°C.The effect of structural changes,acidity,and redox properties of CZW on the SCR activity was investigated.The results indicated that the excellent hydrothermal stability of CZW was mainly due to the CeO_2–ZrO_2 solid solution,amorphous WO_3 phase and optimal acidity.In addition,the formation of WO_3 clusters increased in size as the hydrothermal aging temperature increased,resulting in the collapse of structure,which could further affect the acidity and redox properties. | Zhongxian Song Ping Ning Qiulin Zhang Hao Li Jinhui Zhang Yancai Wang Xin Liu Zhenzhen Huang | 2016 | Journal of Environmental Sciences2016，28，4： | 7 |
| 12 | Resveratrol compares with melatonin in improving in vitro porcine oocyte maturation under heat stress显示文摘Background: Resveratrol, an important phyto-antioxidant commonly found in grapes, mulberry, and other plants,has a variety of functions including anti-aging, anti-cancer and anti-inflammatory activities. In the current study, we investigated the beneficial effects of resveratrol on in vitro porcine oocyte maturation under heat stress(HS). The effect of resveratrol, melatonin and their combination on alleviating HS was compared according to the maturation rate of oocytes and the development competence of embryos after parthenogenetic activation(PA).Results: Supplementation with resveratrol(2.0 μmol/L) not only improved the nuclear maturation but also raised the blastocyst rate of porcine embryos' PA from oocytes that underwent HS by increasing their glutathione(GSH)level, reducing reactive oxygen species(ROS) and up-regulating the expression of Sirtuin 1(SIRT1). It was also found that melatonin(10^(-7)mol/L) and the combination of resveratrol(2.0 μmol/L) plus melatonin(10^(-7)mol/L) exhibited more potent effects than resveratrol alone regarding their protective activities on oocyte maturation under HS.Conclusions: This study compared the efficiencies of resveratrol, melatonin and their combination for protecting porcine oocytes from heat stress. The mechanisms are attributed to the fact that each treatment may have different ability to regulate the synthesis of steroid hormones and the expression of mature related genes. | Yu Li Jing Wang Zhenzhen Zhang Jinyun Yi Changjiu He Feng Wang Xiuzhi Tian Minghui Yang Yukun Song Pingli He Guoshi Liu | 2017 | Journal of Animal Science and Biotechnology2017，8，1： | 7 |
| 13 | Discovery of nitric oxide in marine ecological system and the chemical characteristics of nitric oxide显示文摘Nitric oxide was discovered in both the lab and the alga culture pond of Daya Bay (1―300 m3) before the growth of alga reached the maximum. The results included: (1) NO was detected before the growth of alga reached the maximum in the case of red tide alga and food alga, and the concentration of NO decreased rapidly after the growth maximum; (2) the curve between NO con-centration and time indicated that the concentration of NO in the daytime was more than that at night, and the maximal concentration of NO appeared in the midday (1―3 pm); (3) the growth of alga reached the maximum in the alga culture pond of Daya Bay in about 8―10 d, and NO was discovered in 5―7 d; (4) the measured NO concentration was 10-9 mol/L, 10-9―10-8 mol/L, and 10-8 mol/L for Haeterosigma akashiwo, mixed alga in Daya Bay and Chaetoceros Curvisetus individually; (5) the relation of illumination with NO production was discussed. | ZHANG Zhengbin XING Lei WU Zhenzhen LIU Chunying LIN Cai LIU Liansheng | 2006 | Science China Chemistry2006，49，5： | 7 |
| 14 | Influence of alloying elements on hot tearing susceptibility of Mg-Zn alloys based on thermodynamic calculation and experimental显示文摘Based on the hot tearing index|△T/△(fs)^(0.5)|recently proposed by Kou and the thermodynamic calculations of Pandat software,Al,Cu,and Mn elements were picked up and their influence on hot tearing susceptibility of Mg-x Zn(x=6,8,10,wt%)alloys was studied by experiments.The results indicate that Al addition can significantly reduce the hot tearing susceptibility of Mg-Zn alloys.Either 0.5Cu or 0.3Mn addition individually can reduce the HTS of the Mg-6Zn-(1,4)Al alloys,while adding together increases the susceptibility.The addition of 0.5Cu and 0.3Mn both individually and together increases the HTS of Mg-8/10Zn-1Al alloys.Based on the experimental and calculation results,the index can be modified to|△T/△(fs)^(0.5)|(d)^(2)for more accurate prediction on the hot tearing resistance of Mg-Zn based alloys.Grain refinement significantly improves the hot tearing resistance of Mg-Zn based alloys. | Zhenzhen Yang Ke Wang Penghuai Fu Liming Peng Bin Hu Ming Liu Anil K.Sachdev | 2018 | Journal of Magnesium and Alloys2018，6，1： | 6 |
| 15 | PAQR10 and PAQR11 mediate Ras signaling in the Golgi apparatus显示文摘地岬在许多细胞的活动起一个枢轴的作用,并且它的 subcellular 区分提供空间、时间的选择。这里,我们报导由二高度相应的蛋白质 PAQR10 和孕激素和 AdipoQ 受体家庭的 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个模式。PAQR10 和 PAQR11 在 Golgi 仪器是只局部性的。PAQR10/PAQR11 的 Overexpression 刺激基础、导致 EGF 的英皇家空军之阶级最低之兵 phosphorylation 并且以一种剂量依赖者方式增加英皇家空军之阶级最低之兵目标基因的表示。PAQR10/PAQR11 的 Overexpression 显著地提高 HRas, NRas 和 KRas4A 的 Golgi 本地化,然而并非 KRas4B。PAQR10 和 PAQR11 罐头也与 HRas, NRas 和 KRas4A 交往,然而并非 KRas4B。在由 PAQR10/PAQR11 的 overexpression 的 Golgi 仪器的增加的地岬蛋白质处于一个活跃状态。一致地, PAQR10 和 PAQR11 还原剂击倒在 Golgi 仪器的刺激 EGF 的英皇家空军之阶级最低之兵 phosphorylation 和地岬激活。有趣地, PAQR10 和 PAQR11 能与 RasGRP1,地岬的 guanine 核苷酸交换蛋白质,和 RasGRP1 的增加 Golgi 本地化交往。RasGRP1 的 C1 领域为和 PAQR10/PAQR11 的 RasGRP1 的相互作用必要、足够。由 overexpressed PAQR10/PAQR11 的英皇家空军之阶级最低之兵 phosphorylation 的模拟被 RasGRP1 的 downregulation 废除。而且, PC12 房间的区别被 PAQR10/PAQR11 的 overexpression 显著地提高。一起,这研究揭开由 PAQR10 和 PAQR11 在 Golgi 仪器发信号的地岬的空间规定的一个新范例。 | Ting Jin Qiurong Ding Heng Huang Daqian Xu Yuhui Jiang Ben Zhou Zhenghu Li Xiaomeng Jiang Jing He Weizhong Liu Yixuan Zhang Yi Pan Zhenzhen Wang Walter G Thomas Yan Chen | 2012 | Cell Research2012，22，4： | 6 |
| 16 | Transcriptome Profiling Reveals Auxin and Cytokinin Regulating Somatic Embryogenesis in Different Sister Lines of Cotton Cultivar CCRI24显示文摘在在棉花(Gossypium hirsutum L.) 位于体的 embryogenesis (SE ) 下面的分子的机制上得到一个更宽广的看法,棉花 transcriptome 动力学的全球分析用 RNA-Seq 在在不同姐妹线的 SE 期间被执行。204349 unigenes 的一个总数被 214977462 Illumina 的汇编读的 de novo 检测。量的反向的 transcriptionpolymerase 链反应(qRT-PCR ) 大小断然与几乎所有测试基因的 RNA-Seq 结果被相关(R2=0.841,关联在 0.01 水平是重要的) 。不同植物激素(植物生长素和细胞激动素) 在媒介和在在不同姐妹线的二个阶段的这二植物激素的内长的内容变化的集中比率在棉花 SE 期间建议了植物生长素和细胞激动素的角色。根据植物激素相关的基因的全球基因规定,从所有差别的众多的基因表示了抄本涉及植物生长素和细胞激动素生合成和信号 transduction 小径。差别的分析表示了涉及揭示的这些小径的基因在在二根姐妹线之间的基因类型和丰富的实质的变化。隔离,克隆并且在棉花 SE 期间揭示了显著起来表示或下面表示的基因是的 silencing/overexpressing 重要。而且,植物生长素和细胞激动素与对方或另外的因素遗体一起在 SE,而是潜在的串音起一个主要作用不清楚。 | Zhenzhen Xu Chaojun Zhang Xueyan Zhang Chuanliang Liu Zhixia Wu Zuoren Yang Kehai Zhou Xiaojie Yang Fuguang Li | 2013 | Journal of Integrative Plant Biology2013，55，7： | 5 |
| 17 | Laser probe ^(40)Ar/^(39)Ar dating for quartz from auriferous quartz veins in the Shihu gold deposit,western Hebei Province,North China显示文摘The Shihu gold deposit is situated in the central shear zone of the Meso-Cenozoic Fuping metamorphic core complex in the middle-northern part of the Taihang Mountains.This kind of gold deposits named after 'Shihu type' widely occurs in this region.Gold-bearing quartz veins are their most important industrial orebodies.Detailed laser 40Ar/39Ar geochronology of the mineralized quartz veins in the study area reveals details of its tectono-magmatic history.The 40Ar/39Ar ages for the quartz are between 134.4 Ma and 155.9 Ma with a mean age of 141±4 Ma on the isochron line and 139±7 Ma on the inverse isochron line,respectively,which is interpreted to be the best estimate of the crystalline age of the quartz veins.The gold mineralization was most likely related to an underplating event that took place in the northern part of the Taihang Mountain at ca.140 Ma.The timing of gold mineralization in the area is similar to those observed in other major gold-producing provinces in the NCC.This episode is simultaneous with those in the eastern NCC,indicative of a widespread late Yanshanian metallogenic event that was a response either to the subduction of the Izanagi-Pacific plate beneath eastern China or to the removal of the Early Cretaceous lithosphere in the eastern NCC.The ore-forming material sources may be the Early Precambrian metamorphic basement,instead of intermediate-acid rock bodies and dykes. | CAO Ye LI Shengrong ZHANG Huafeng AO Chong LI Zhenzhen LIU Xiaobin | 2010 | Chinese Journal Of Geochemistry2010，29，4： | 5 |
| 18 | Effect of electro-scalp acupuncture on acute ischemic stroke: a randomized, single blind, trial显示文摘OBJECTIVE: To determine the clinical efficacy and safety of electro-scalp acupuncture in the treatment of patients with acute ischemic stroke.METHODS: Totally 74 patients with acute ischemic stroke were enrolled and divided into either body acupuncture(Control) or electro-scalp acupuncture(ESA) groups according to randomized controlled principle. The patients in the control group weregiven body acupuncture treatment once daily for28 d, whereas except for the body acupuncture,electro-scalp acupuncture was additional treatment given to the ESA group. Neurological deficits,everyday motor function and muscle strength were evaluated at baseline and the 28 th d by NIH Stroke Scale(NIHSS), Fugl-Meyer Assessment(FMA) and Modified Barthel Index Score(MBI), respectively.RESULTS: There were not obvious between-group differences in the baseline efficacy parameters(NIHSS, FMA and MBI)(all P > 0.05), whereas significant between-group differences were found in post-treatment NIHSS, FMA-UE and MBI scores(all P < 0.05). After acupuncture treatment, systematic within-group improvements were found in the two groups for any of the efficacy parameters assessed(all P < 0.01), and the ESA group showed higher significant improvements in NIHSS, FMA-UE and MBI scores(all P < 0.05).CONCLUSION: Electro-scalp acupuncture was efficacious in the treatment of acute ischemic stroke,which resulted in meaningful improvements in neurologic function, motor function and activities of daily living of patients. | Liu Xiaoxi Zhang Xuezhu Nie Kun Jia Yujie Li Jing Ling Zhenzhen Wang Yao Chang Shichen | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 5 |
| 19 | Introduction of a multicenter online database for non-metastatic breast cancer in China显示文摘Dear Editor,Breast cancer is now the most frequently diagnosed cancer and is the fifth leading cause of cancer-related death in Chinese women. Therefore, the burden of breast cancer in China is gradually increasing. According to figures released by the Chinese Cancer Center in 2018, the number of newly diagnostic breast cancer is about 278,900 cases, accounting for 16.51%of all women who were diagnosed with the first primary malignant tumors;and 66,000 cases of breast cancer died in 2014 (Chen et al., 2016). | Yaping Yang Jieqiong Liu Min Peng Fengxi Su Xiaoming Xie Zhenzhen Liu Jundong Wu Wei Wei Dongxian Zhou Weiwen Li Ailing Zhang Guosen Su Weixiong Yang Jishang Chen Dekui Ma Yongguang Cai Kai Chen Liling Zhu Qiang Liu Erwei Song | 2020 | Science China(Life Sciences)2020，63，9： | 4 |
| 20 | Reversing cold tumors to hot: An immunoadjuvant-functionalized metalorganic framework for multimodal imaging-guided synergistic photoimmunotherapy显示文摘Immunotherapy assays using immunoadjuvants and tumor antigens could greatly increase the survival rates of patients with malignant tumors.As effective carriers,metal-organic frameworks(MOFs)have been widely utilized in cancer therapy due to their remarkable histocompatibility and low toxicity.Herein,we constructed a multimodal imaging-guided synergistic cancer photoimmunotherapy by employing a specific MOF(MIL101-NH2)as the core carrier;the MOF was dual-dressed with photoacoustic and fluorescent signal donors(indocyanine green,ICG)and immune adjuvants(cytosine-phosphate-guanine sequence,CpG)and named ICGCpG@MOF.This nanocarrier could passively target the tumor site through the EPR effect and achieve multimodal imaging(fluorescence,photoacoustic,photothermal and magnetic resonance imaging)of the tumor.Synergistic cancer photoimmunotherapy was achieved via simultaneous photodynamic and photothermal methods with 808 nm laser irradiation.ICG-CpG@MOF achieved the GSH-controlled release of immunoadjuvant into the tumor microenvironment.Furthermore,the released tumor-associated antigen along with CpG could induce the transformation of tumor cells from cold to hot by activating the immune system,which significantly enhanced tumor cytotoxicity and achieved high cure rates with minimal side-effects.This strategy utilizing multimodal imaging and synergistic cancer photoimmunotherapy provides a promising approach for the diagnosis and treatment of cancer. | Zhijin Fan Hongxing Liu Yaohua Xue Jingyan Lin Yu Fu Zhaohua Xia Dongming Pan Jian Zhang Kun Qiao Zhenzhen Zhang Yuhui Liao | 2021 | Bioactive Materials2021，6，2： | 4 |
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