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| 1 | Time-lapse geophysical technology-based study on overburden strata changes induced by modern coal mining显示文摘To study the impact of modern coal mining on overlying strata and its water bearing conditions,integrated time-lapse geophysical prospecting integrating 3D seismic,electrical and ground penetrating radar method were used.Through observing and analyzing the geophysical data variations of all stages of pre-mining,mining and post-mining as well as post-mining deposition stable period,impacts of coal mining on stratigraphic structure and its water bearing were studied and modern coal mining induced stratigraphic change pattern was summarized.The research result shows that the stratigraphic structure and the water bearing of surface layer during modern coal mining have self-healing pattern with mining time;the self-healing capability of near-surface strata is relatively strong while the roof weak;water bearing selfhealing of near-surface strata is relatively high while the roof strata adjacent to mined coal beds low.Due to integrated time-lapse geophysical prospecting technology has extra time dimension which makes up the deficiency of static analysis of conventional geophysical methods,it can better highlight the dynamic changes of modern coal mining induced overburden strata and its water bearing conditions. | Wenfeng Du Suping Peng Guowei Zhu Feng Yang | 2014 | International Journal of Coal Science & Technology2014，1，2： | 16 |
| 2 | Oil-soluble ionic liquids as antiwear and extreme pressure additives in poly-α-olefin for steel/steel contacts显示文摘To enhance the lubricating and extreme pressure(EP) performance of base oils, two types of oil-soluble ionic liquids(ILs) with similar anion albeit dissimilar cations were synthesized. The physical properties of the prepared ILs were measured. The anticorrosion properties of ILs were assessed by conducting corrosion tests on steel discs and copper strips, which revealed the remarkable anticorrosion properties of the ILs in comparison with those of the commercial additive zinc dialkyldithiophosphate(ZDDP). The tribological properties of the two ILs as additives for poly-α-olefin-10(PAO10) with various mass concentrations were investigated. The tribological test results indicate that these ILs as additives are capable of reducing friction and wear of sliding contacts remarkably as well as enhance the EP performance of blank PAO10. Under similar test conditions, these IL additives exhibit higher lubricating and anti-wear(AW) performances than those of ZDDP based additive package in PAO10. Subsequently, X-ray photoelectron spectroscopy(XPS) and energy dispersive spectrometer(EDS) were conducted to study the lubricating mechanism of the two ILs. The results indicate that the formation of tribochemical film plays the most crucial role in enhancing the lubricating and AW behavior of the mixture lubricants. | Guowei HUANG Qiangliang YU Zhengfeng MA Meirong CAI Feng ZHOU Weimin LIU | 2019 | Friction2019，7，1： | 15 |
| 3 | A more consistent intraluminal rhesus monkey model of ischemic stroke显示文摘Endovascular surgery is advantageous in experimentally induced ischemic stroke because it causes fewer cranial traumatic lesions than invasive surgery and can closely mimic the pathophysiology in stroke patients. However, the outcomes are highly variable, which limits the accuracy of evaluations of ischemic stroke studies. In this study, eight healthy adult rhesus monkeys were randomized into two groups with four monkeys in each group: middle cerebral artery occlusion at origin segment(M1) and middle cerebral artery occlusion at M2 segment. The blood flow in the middle cerebral artery was blocked completely for 2 hours using the endovascular microcoil placement technique(1 mm × 10 cm)(undetachable), to establish a model of cerebral ischemia. The microcoil was withdrawn and the middle cerebral artery blood flow was restored. A reversible middle cerebral artery occlusion model was identified by hematoxylin-eosin staining, digital subtraction angiography, magnetic resonance angiography, magnetic resonance imaging, and neurological evaluation. The results showed that the middle cerebral artery occlusion model was successfully established in eight adult healthy rhesus monkeys, and ischemic lesions were apparent in the brain tissue of rhesus monkeys at 24 hours after occlusion. The rhesus monkeys had symptoms of neurological deficits. Compared with the M1 occlusion group, the M2 occlusion group had lower infarction volume and higher neurological scores. These experimental findings indicate that reversible middle cerebral artery occlusion can be produced with the endovascular microcoil technique in rhesus monkeys. The M2 occluded model had less infarction and less neurological impairment, which offers the potential for application in the field of brain injury research. | Bo Zhao Guowei Shang Jian Chen Xiaokun Geng Xin Ye Guoxun Xu Ju Wang Jiasheng Zheng Hongjun Li Fauzia Akbary Shengli Li Jing Lu Feng Ling Xunming Ji | 2014 | Neural Regeneration Research2014，9，23： | 6 |
| 4 | Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity显示文摘Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research. | Xuanming Chen Cheng Shen Zhe Wei Rui Zhang Yongsheng Wang Lili Jiang Ke Chen Shuang Qiu Yuanli Zhang Ting Zhang Bin Chen Yanjun Xu Qiyi Feng Jinxing Huang Zhihui Zhong Hongxia Li Guowei Che Kai Xiao | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 5 | Human embryonic stem cells-derived endothelial cell therapy facilitates kidney regeneration by stimulating renal resident stem cell proliferation in acute kidney injury显示文摘Endothelial cell therapy has been implicated to enhance tissue regeneration and vascularization in ischemic kidney. However, no published study has yet examined direct effects of endothelial cell treatment in kidney recovery. This study investigated the therapeutic efficacy of endothelial cells in a mouse model with acute kidney injury (AKI). Thus, human embryonic stem cells-derived endothelial cells (hESC-ECs) labeled with a reporter system encoding a double fusion reporter gene for firefly luciferase (Fluc) and green fluorescent protein (GFP) were characterized by Fluc imaging and immunofluoresence staining. Cultured hESC-ECs (1×106) were injected into ischemic kidney shortly after AKI. Survival of the transplanted hESC-ECs was monitored in vivo from day 1 to 14 after endothelial cell transplantation and potential impact of hESC-EC treatment on renal regeneration was assessed by histological analyses. We report that a substantial level of bioluminescence activity was detected 24 h after hESC-EC injection followed by a gradual decline from 1 to 14 d. Human ESC-ECs markedly accelerated kidney cell proliferation in response to ischaemia-induced damage, indicated by an elevated number of BrdU+ cells. Co-expression of Sca-1, a kidney stem cell proliferation marker, and BrdU further suggested that the observed stimulation in renal cell regeneration was, at least in part, due to increased proliferation of renal resident stem cells especially within the medullary cords and arteriole. Differentiation of hESC-ECs to smooth muscle cells was also observed at an early stage of kidney recovery. In summary, our results suggest that endothelial cell therapy facilitates kidney recovery by promoting vascularization, trans-differentiation and endogenous renal stem cell proliferation in AKI. | JIA XiaoHua L He LI Chen FENG GuoWei YAO XinPeng MAO LiNa KE TingYu CHE YongZhe XU Yong LI ZongJin KONG DeLing | 2013 | Chinese Science Bulletin2013，58，23： | 4 |
| 6 | Simulation of viscoelastic behavior of defected rock by using numerical manifold method显示文摘Numerical simulations of longitudinal wave propagation in a rock bar with microcracks are conducted by using the numerical manifold method which has great advantages in the simulation of discontinuities.Firstly,validation of the numerical manifold method is carried out by simulations of a longitudinal stress wave propagating through intact and cracked rock bars.The behavior of the stress wave traveling in a one-dimensional rock bar with randomly distributed microcracks is subsequently studied.It is revealed that the highly defected rock bar has significant viscoelasticity to the stress wave propagation.Wave attenuation as well as time delay is affected by the length,quantity,specific stiffness of the distributed microcracks as well as the incident stress wave frequency.The storage and loss moduli of the defected rock are also affected by the microcrack properties;however,they are independent of incident stress wave frequency. | Feng REN Lifeng FAN Guowei MA | 2011 | Frontiers of Structural and Civil Engineering2011，5，2： | 3 |
| 7 | Temperature Characteristics of Surface Acoustic Waves Propagating on La_3Ga_5SiO_4 Substrates显示文摘Langasite (LGS) is a novel piezoelectric crystal. The authors numerically analyses the temperature stability of surface acoustic waves (SAW) and the relation of SAW propagation with temperature on certain optimal cuts on LGS in this paper. The results show that LGS has better temperature stability than traditional piezo crystals. The results alsodemonstrate that the velocity of SAW decrease with temperature, the electro-mechanical coupling constant (k2) and temperature coefficient of frequency increases parabolically and the power flow angle increases linearly on certain optimal cuts of LGS. The calculation result compared with the experimental and show good agreement. | Guowei ZHANG, Wenkang SHI, Xiaojun JI, Tao HAN, Feng DU and Lianger LISchool of Electronics & Information, Shanghai Jiao Tong University, Shanghai 200030, China | 2004 | Journal of Materials Science & Technology2004，20，1： | 2 |
| 8 | Localized FCM Clustering with Spatial Information for Medical Image Segmentation and Bias Field Estimation显示文摘 | Wenchao Cui Yi Wang Yangyu Fan Yan Feng Tao Lei Guowei Wei | 2013 | International Journal of Biomedical Imaging2013，，： | 1 |
| 9 | Impact of Wind Integration on Transient Voltage Stability in Regional Grid显示文摘With the increasing development of wind power,the scale of wind farms and unit capacity of wind turbines are getting larger and larger,and the impact of wind integration on power systems cannot be ignored.However,in most cases,the areas with a plenty of wind resources do not have strong grid structures.Furthermore,the characteristics of wind power dictate that wind turbines need to absorb reactive power during operation.Because of the strong correlation between voltage stability and systems' reactive power,the impacts of wind integration on voltage stability has become an important issue.Based on the power system simulation software DIgSILENT and combined analysis of actual practice,this paper investigates the impacts of two types of wind farms on voltage stability:namely a type of wind farms which are constituted by constant speed wind turbines based on common induction generators(IG) and another type of wind farms which are constituted by VSCF wind turbines based on doubly-fed induction generators(DFIG).Through investigation the critical fault clearing time is presented for different outputs of wind farms.Moreover,the impacts of static var compensator(SVC) and static synchronous compensator(STATCOM) on transient voltage stability in IG-based wind farms are studied to improve the security and stability of the Jiangsu power grid after the integration of large scale wind power. | Zhang Feng Li Mingxia Fan Guowei Luo Zhongyou Chang Xiqiang | 2012 | Electricity2012，23，2： | 1 |
| 10 | Maximum likelihood least squares identification method for input nonlinear finite impulse response moving average systems 显示文摘 | LI Junhong DING Feng YANG Guowei | 2012 | Mathematical and Computer Modelling2012，55，34： | 1 |
| 11 | In-situ experimental investigation of the influence of structure characteristics on subway-induced building vibrations显示文摘Many types of buildings have been widely constructed in the vicinity of subway lines in China.Normal life and business activities are hampered by excessive subway-induced vibrations.This study aims to determine the influence of structure characteristics on structure-borne vibrations,generally based on experimental results.Vibration measurements were performed in four typical sites in Wuxi,China,involving over-track buildings,along-track buildings,frame structure buildings and a masonry building.Special structure designs like structure transfer floor were also included.Then,the captured data was analyzed in the time domain and the frequency domain.Furthermore,the influence of building location,structure type and structure layout was investigated.Finally,vibrations were evaluated with ISO and Chinese criteria and structure optimization for vibration attenuation was proposed.It is found that over-track buildings are more severely affected than along-track buildings.Higher frequency contents(20‒60 Hz)in over-track buildings and lower frequency contents(0‒10 Hz)in along-track buildings should be seriously considered in vibration control.Weaker structure member joints and lower material strength would be beneficial to over-track buildings while the inverse situation would be beneficial to along-track buildings.The application of structure transfer floor‒generally stiffer structure members and structure discontinuity‒is also beneficial. | Feng Shijin Li Fuhao Zhang Xiaolei Dong Guowei Li Jianping | 2021 | Earthquake Engineering and Engineering Vibration2021，20，3： | 1 |
| 12 | An adaptive fault-tolerant communication scheme for body sensor networks显示文摘 | Wu Guowei Ren Jiankang Xia Feng | 2010 | Sensors2010，10，11： | 1 |
| 13 | BMP9 inhibits the bone metastasis of breast cancer cells by downregulating CCN2 (connective tissue growth factor, CTGF) expression显示文摘 | Wei Ren Xiaoxiao Sun Ke Wang Honglei Feng Yuehong Liu Chang Fei Shaoheng Wan Wei Wang Jinyong Luo Qiong Shi Min Tang Guowei Zuo Yaguang Weng Tongchuan He Yan Zhang | 2014 | Molecular Biology Reports2014，，3： | 1 |
| 14 | Air pollution and children’s respiratory symptoms in six cities of Northern China显示文摘 | Guowei Pan Shujuan Zhang Yiping Feng Ken Takahashi Jun Kagawa Lianzheng Yu Ping Wang Meijuan Liu Qinan Liu Shuwen Hou Bailing Pan Jianping Li | 2010 | Respiratory Medicine2010，，12： | 1 |
| 15 | A flame-retardant binder with high polysulfide affinity for safe and stable lithium–sulfur batteries显示文摘Lithium-sulfur(Li-S) batteries have shown promises for the next-generation, high-energy electrochemical storage, yet are hindered by rapid performance decay due to the polysulfide shuttle in the cathode and safety concerns about potential thermal runaway. To address the above challenges, herein, we show a flame-retardant cathode binder that simultaneously improves the electrochemical stability and safety of batteries. The combination of soft and hard segments in the polymer framework of binders allows high flexibility and mechanical strength for adapting to the drastic volume change during the Li(de)intercalation of the S cathode. The binder contains a large number of polar groups, which show the high affinity to polysulfides so that they help to anchor active S species at the cathode. These polar groups also help to regulate and facilitate the Li-ion transport, promoting the kinetics of polysulfide conversion reaction. The binder contains abundant phosphine oxide groups, which, in the case of battery's thermal runaway, decompose and release PO· radicals to quench the combustion reactions and stop the fire. Consequently, Li-S batteries using the new cathode binder show the improved electrochemical performance, including a low-capacity decay of 0.046% per cycle for 800 cycles at 1 C and favorable rate capabilities of up to 3 C. This work offers new insights on the practical realization of high-energy rechargeable batteries with stable storage electrochemistry and high safety. | Guowei Yu Guofeng Ye Cheng Wang Chenyang Wang Zhaoyun Wang Pu Hu Yu Li Xi-Xi Feng Shuang-Jie Tan Min Yan Sen Xin Zhitian Liu | 2024 | Science China Chemistry2024，67，3： | 0 |
| 16 | Urinary Myeloperoxidase to Creatinine Ratio as a New Marker for Diagnosis of Urinary Tract Infection显示文摘Objective To determine whether urinary myeloperoxidase to creatinine ratio(MCR)can serve as a marker for diagnosis of urinary tract infection(UTI).Methods Patients suspected of UTI were consecutively enrolled and further divided into the culture positive and the sterile groups according to urine culture results.Subsequently,MCR,white blood cell(WBC)and bacteria in the urinary samples from patients were detected and compared between the two groups.Results Finally,253 patients were enrolled including 157 urine culture positive patients and 96 urine culture negative patients(sterile group).After logarithmic transformation in 2 as the base,the MCR,WBC,and bacteria were separately presented as log2 MCR,log2 WBC(quantitative),and log2 bacteria.The values of log2 MCR(8.6±2.5 vs.5.4±1.5,t=-12.453,P=0.001),log2 WBC(quantitative)(8.0±2.5 vs.5.2±1.8,t=-10.332,P=0.001),log2 bacteria(11.4±2.5 vs.8.2±2.8,t=-9.297,P=0.001)and WBC(semi-quantitative)[2(interquartile range 1,3)vs.1(interquartile range 0.5,1),Z=-7.580,P=0.001]showed significant difference between the urine culture positive group and the sterile group.Among the urine culture positive group,the values of log2 MCR of the gram positive and gram negative subgroups were 7.2±2.5 and 9.0±2.4(t=4.016,P=0.001),respectively.The correlation between log2 MCR and log2 WBC(quantitative),log2 bacteria,WBC(semi-quantitative)was 0.708(Pearson correlation,P=0.001),0.381(Pearson correlation,P=0.001),and 0.606(Spearman correlation,P=0.001),respectively.Conclusions MCR is positively correlated with WBC counts and could be served as a promising biomarker for diagnosis of UTI.MCR could be even used for initial inference of infectious bacteria types of UTI. | Mingjian Bai Jing Feng Guowei Liang | 2018 | Chinese Medical Sciences Journal2018，33，3： | 0 |
| 17 | Enhanced Adhesion of Mussel-inspired Adhesive through Manipulating Contents of Dopamine Methacrylamide and Molecular Weight of Polymer显示文摘 | Xiong Xiong Yumei Liu Feng Shi Guowei Zhang Jie Weng Shuxin Qu | 2018 | Journal of Bionic Engineering2018，15，3： | 0 |
| 18 | Effect of bone marrow stromal cell transplantation to the hippocampal CA1 region on electroencephalographic activity in epileptic rats显示文摘BACKGROUND: Animal experiments have confirmed that bone marrow stromal cell (BMSC) transplantation can serve as a treatment for epilepsy. OBJECTIVE: BMSCs derived from green fluorescent protein (GFP) mice were transplanted into the hippocampal CA1 region of epileptic rats. The aim of the study was to record electroencephalogram (EEG), analyze survival and migration of BMSCs, and validate the effect of BMSC transplantation for the treatment of epilepsy. DESIGN, TIME AND SETTING: A randomized block design experiment was performed at the Institute of Neuroscience, Kunming Medical College from March 2005 to February 2006. MATERIALS: Homozygous C57BL/6CrSlcTgN (acr-EGFP) OsbC 14-Y01-FM131 mice, 8-12 weeks of age, were selected for preparation of cell suspension. Sprague Dawley rats were selected for establishing epilepsy models. METHODS: Rats were randomly divided into 4 groups: control (n = 8), model (n = 8), normal saline (n = 24), and BMSC (n = 24). In the model, normal saline, and BMSC groups, epilepsy was established with penicillin (3 × 107 U/kg i.p. ×7 days). Rats in the BMSC group received a BMSC suspension derived from green fluorescent protein mice into the right hippocampal CA1 region. Rats in the vehicle control group were injected with the same volume of normal saline into the hippocampal CA1 region. MAIN OUTCOME MEASURES: The electroencephalogram was used to monitor brain activity. Survival and migration of the transplanted BMSCs was observed using fluorescence microscopy at 1, 2, and 4 weeks after transplantation. RESULTS: In BMSC group, fluorescent cells were observed at the transplantation site and in the adjacent tissue, as well as in the tissue surrounding the needle tract, indicating the migration of implanted cells. Fluorescent cells were not detected in the vehicle control group. The electroencephalogram of the control animals exhibited 7-9 Hz α waves, with a wave amplitude < 50 μV. In the model and vehicle control groups, random spike-and-wave discharges of the sharp spike-sharp low wave type were observed. EEG amplitudes were significantly smaller in the BMSC group, compared with the model and vehicle control groups. CONCLUSION: Following transplantation, BMSCs survived and migrated to the injury region of the epileptic rat brain and alleviated epileptic seizures. | Hong Xu Guowei Xu Zhongtang Feng Tinghua Wang Jia Yang Qingying Wu Zhicheng Xiao | 2008 | Neural Regeneration Research2008，3，10： | 0 |
| 19 | Macroscale superlubricity achieved via hydroxylated hexagonal boron nitride nanosheets with ionic liquid at steel/steel interface显示文摘Macroscale superlubricity is a prospective strategy in modern tribology to dramatically reduce friction and wear of mechanical equipment;however,it is mainly studied for point-to-surface contact or special friction pairs in experiments.In this study,a robust macroscale superlubricity for point-to-point contact on a steel interface was achieved for the first time by using hydroxylated modified boron nitride nanosheets with proton-type ionic liquids(ILs)as additives in ethylene glycol aqueous(EG_(aq)).The detailed superlubricity process and mechanism were revealed by theoretical calculations and segmented experiments.The results indicate that hydration originating from hydrated ions can significantly reduce the shear stress of EG_(aq),which plays an essential role in achieving superlubricity.Moreover,the IL induces a tribochemical reaction to form a friction-protective film.Hydroxylated boron nitride nanosheets(HO-BNNs)function as a polishing and self-repairing agent to disperse the contact stress between friction pairs.Superlubricity involves the change in lubrication state from boundary lubrication to mixed lubrication.This finding can remarkably extend the application of superlubricity for point-to-point contact on steel surfaces for engineering applications. | Zhiwen ZHENG Xiaolong LIU Guowei HUANG Haijie CHEN Hongxiang YU Dapeng FENG Dan QIAO | 2022 | Friction2022，10，9： | 0 |
| 20 | Visualization of Ferroelectric Domains in Thin Films of Molecular Materials Using Confocal Micro-Raman Spectroscopy显示文摘Ferroelectrics are an important class of functional materials.Among all their unique properties,the study of their ferroelectric domains and domain walls is of great interest due to their importance in ferroelectric applications.There are many methods to characterize ferroelectric domains,namely,scanning probe microscopy,optical microscopy,electron microscopy,etc.Currently,newly emerged molecular ferroelectrics are attracting much attention from chemists,physicists and researchers in material sciences due to their structural flexibility,light mass,simple fabrication,etc.However,for the characterization of molecular ferroelectric domains,most conventional methods require either a complicated preparation process or direct contact between physical probes and material surfaces,limiting the development of molecular ferroelectric materials.In this report,we have demonstrated that confocal micro-Raman spectroscopy,as a nondestructive and noncontact in-situ method,is very suitable for studying the ferroelectric polarization and structures of domains in molecular ferroelectrics.Taking recently reported molecular ferroelectric trimethylchloromethyl ammonium trichlorocadmium(II)(TMCM-CdCl_(3))as an example,the non-180°domains have been characterized and visualized at different temperatures.Such a simple and extendable method requires minimum sample preparation,which would further benefit the research of molecular ferroelectric domain engineering and promote the miniaturization and integration of molecular ferroelectric films. | ZHOU Wenqin FENG Zijie XIONG Yuan DU Guowei LIN Xiumei SU Qidong LOU Yuheng AN Shili YOU Yumeng | 2022 | Chemical Research in Chinese Universities2022，38，6： | 0 |
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