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| 1 | Observation analysis on characteristics of formation,evolution and transition of a long-lasting severe fog and haze episode in North China显示文摘An unusual fog and haze event lasted for one week took place during 1–7 December,2011 over North China.To investigate the characteristics and mechanism of formation,evolution,and transition of the fog and haze event,we studied the microphysical properties such as aerosol,cloud condensation nuclei(CCN),fog droplet spectrum and liquid water content(LWC),as well as horizontal visibility and boundary layer properties,using the data collected in the Project of Low-Visibility Weather Monitoring and Forecasting in the Beijing-Tianjin region.The results indicate that the long-lasting fog and haze event occurred in a high pressure weather system and calm wind condition.The stable boundary-layer structure resulted from temperature inversions that were built by warm advection and radiation cooling provided a favorable condition for the accumulation of polluted aerosols and the formation and development of the fog and haze event.In particular,the continuous southerly wet flow advection made the process a persistent and long-lasting event.The horizontal visibility was almost below 2 km in the whole process,and the lowest visibility was only 56 m.The average LWC was about 10-3 g m-3,and the maximum LWC reached 0.16 g m-3.The aerosol number concentration was more than 10000 cm-3,and its mass concentration ranged from 50 to 160 -g m-3.The further study shows that the fog and haze event experienced three main processes in different intensities during the whole period,each process could be divided into three main stages:aerosol accumulation,transition and mixture of aerosol and fog,and dissipation.Each stage had different physical features:the aerosol accumulation stage was characterized by the increase of aerosol number concentration in Aitken nuclei and accumulation mode sequentially.In the transition and mixing stage of fog and haze,the latent heating produced by fog droplet condensation process and high aerosol number concentration condition intensified the Brownian coagulation process,which induced the small size of aerosols to become larger ones and enhanced the CCN activation process,thereby promoting the explosive development of the fog event.The ratio of aerosol activated to CCN reached 17%,and the ratio of CCN converted to fog droplet exceeded 100%,showing an explosively broadening of fog droplet spectrum.The decrease and dissipation of the fog was caused by an increased solar radiation heating or the passage of cold frontal system. | GUO LiJun GUO XueLiang FANG ChunGang ZHU ShiChao | 2015 | Science China Earth Sciences2015，58，3： | 22 |
| 2 | Genome-Wide Association Studies of Image Traits Reveal Genetic Architecture of Drought Resistance in Rice显示文摘理解植物怎么对干旱作出回应能有益于繁殖的干旱抵抗(医生) 。用一台非破坏性的 phenotyping 设备,为 507 米饭就职的 51 个基于图象的特点(i 特点) 被提取。这些 i 特点能被用来监视干旱回答 ? 并且高评估医生可遗传性和这些特点的大变化在自然人口在干旱应力下面被观察。染色体宽的协会研究(GWAS )?i 特点和传统的医生特点识别了 470 协会 loci,某包含知道医生相关的基因。这 470 loci, 443 loci (94%) 用 i 特点被识别, 437 loci (93%) 与以前报导的医生相关的量的特点 loci,和 313 loci (66.6%)co 局部性被 GWAS reproducibly 在不同的年里识别。协会网络,基于 GWAS 建立了结果,揭示中心 i 特点和中心 loci。这表明把的可行性和必要性复杂医生特点进可继承、简单的 i 特点。作为原则的证明,我们说明了这条综合途径的力量以前识别 unreported 医生相关的基因。OsPP15 与中心 i 特点被联系,并且它在医生的角色被基因转变实验证实。而且, i 特点能被用于医生连接分析,并且 69 个 i 特点地点协会被 recombinant 的 GWAS 和连接分析识别生来的线人口。最后,我们证实了 i 特点的关联在这个领域里搀。我们的学习为医生为原因的基因的基因解剖和发现提供一条有希望的新奇途径。 | Zilong Guo Wanneng Yang Yu Chang Xiaosong Ma Haifu Tu Fang Xiong Ni Jiang Hui Feng Chenglong Huang Peng Yang Hu Zhao Guoxing Chen Hongyan Liu Lijun Luo Honghong Hu Qian Liu Lizhong Xiong | 2018 | Molecular Plant2018，11，6： | 21 |
| 3 | Silicon-based nanomaterials for lithium-ion batteries显示文摘Silicon-based nanomaterials have been of scientific and commercial interest in lithium-ion batteries due to the low cost,low toxicity,and high specific capacity with an order of magnitude beyond that of conventional graphite.The poor capacity retention,caused by pulverization of Si during cycling,triggers researchers and engineers to explore better battery materials.This review summarizes recent work in improving Si-based anode materials via different approaches from diverse Si nanostructures,Si/metal nanocomposites,to Si/C nanocomposites,and also offers perspectives of the Si-based anode materials. | YIN YaXia WAN LiJun GUO YuGuo | 2012 | Chinese Science Bulletin2012，57，32： | 16 |
| 4 | Water regime-nitrogen fertilizer incorporation interaction:Field study on methane and nitrous oxide emissions from a rice agroecosystem in Harbin, China显示文摘Water regime and nitrogen(N) fertilizer are two important factors impacting greenhouse gases(GHG) emission from paddy field, whereas their effects have not been well studied in cold region. In this study, we conducted a two-year field experiment to study the impacts of water regime and N fertilizer on rice yields and GHG emissions in Harbin, China, a cold region located in high latitudes. Our results showed that intermittent irrigation significantly decreased methane(CH_4) emission compared with continuous flooding, however,the decrement was far lower than the global average level. The N_2O emissions were very small when flooded but peaked at the beginning of the disappearance of floodwater. The N fertilizer treatments increased CH_4 emissions at low level(75 kg N/ha). But both CH_4 and N_2O emissions were uninfluenced at the levels of 150 kg N/ha and 225 kg N/ha. Rice yields increased under intermittent irrigation and were highest at the level of 150 kg N/ha. From our results, we recommended that the intermittent irrigation and 150 kg N/ha as the ideal water regime-nitrogen fertilizer incorporation for this area to achieve low GHG emissions without impacting rice yields. | Wenjun Dong Jia Guo Lijun Xu Zhifeng Song Jun Zhang Ao Tang Xijuan Zhang Chunxu Leng Youhong Liu Lianmin Wang Lizhi Wang Yang Yu Zhongliang Yang Yilei Yu Ying Meng Yongcai Lai | 2018 | Journal of Environmental Sciences2018，30，2： | 12 |
| 5 | Grhl3 induces human epithelial tumor cell migration and invasion via downregulation of E-cadherin显示文摘Grainyhead 基因涉及愈合弯屈和发展神经试管闭合。转移在细胞从主要肿瘤的地点传播哪个癌症并且在远器官建立第二等的肿瘤期间是一个 multistep 过程。粘附蛋白质 E-cadherin 在转移起一个必要作用。考虑到在在皮或乳癌发生在侵略的获得期间的愈合创伤的过程和 EMT 发生的 epithelialmesenchymal 转变(EMT ) 的类似的高度,我们在癌症侵略调查了 Grainyhead 基因的角色。这里,我们证明在象 Grainyhead 一样之间有一种反的关系 3 (Grhl3 ) 并且在某上皮的肿瘤房间的 E-cadherin 表示排队。在 E-cadherin-positive 上皮的肿瘤房间线的 Grhl3 的 Overexpression,由更少的侵略描绘了,产生了 E-cadherin 基因的 transcriptional 阻塞并且支持了房间移植和房间侵略。相反地, Grhl3 弄空禁止了房间移植和房间侵略并且与 E-cadherin 表示的获得被联系。为了推进,探索 Grhl3 由调整了 E-cadherin 表示的机制, E-cadherin 倡导者报告分析被表现,结果出现了那 Grhl3 镇压 E-cadherin 基因表示由对在近似 E-cadherin 倡导者在场的电子盒子直接或间接地有约束力。一起拿,我们的调查结果在癌症房间由 E-cadherin 的 downregulation 在移植和侵略的正式就职为 Grhl3 定义一个主要角色。 | Pan Zhao Sijia Guo Zhenzhen Tu Lijun Di Xiaoiun Zha Haisheng Zhou Xuejun Zhang | 2016 | Acta Biochimica et Biophysica Sinica2016，0，3： | 9 |
| 6 | Precious Fossil-Bearing Beds of the Lower Cretaceous Jiufotang Formation in Western Liaoning Province, China显示文摘在西方的辽宁基于分进更低的白垩纪 JiufotangFormation 的三个成员,这篇论文主要处理宝贵石块鸟的部门和关联 -- 并且在 Dachengzi, Chaoyang, Dapingfang-Meileyingzi 和 Fuxin-Yixian 的形成的忍受爬行动物的床盆。在他们之中,在 theDachengzi 盆的宝贵的忍受石块的床可以作为第二个成员的 Xidagou 床和第三个成员的 YangcaogoudonggouBed 被认出;那些可以作为第二个成员的 Shangheshou 床和第三个成员的 Dongpochi 床在 Chaoyang 盆被证实;那些在 Dapingfang-Meileyingzi Basinare 作为第二个成员,的 Lamagou 床 Huanghuagou 床更低第三张成员和 theYuanjiawa 床上面第三个成员;并且那些作为第二个成员的 theTuanshanzi 床和第三个成员的 Pijiagou 床在 Fuxin-Yixian 盆被列出。因为这些盆清楚地被分开,鸟和爬行动物石块主要是新类和种,我们有篷乱是的联系石块 ostracod 集合相关,并且相关的索引有 theShangheshou 床的 Xidagou 床和 Lamagou 床有 YangcaogoudonggouBed 的 Yuanjiawa 床和 Pijiagou 床。首先,我们在西方的辽宁建立了 Jiufotang 形成的宝贵的忍受石块的床的顺序。他们被代表由在登上顺序,第二个成员,的 theXidagou 床 Huanghuagou 床更低第三个成员,和 YuanjiawaBed 上面第三个成员。显然,这个工作在中间的早白垩纪的时期期间在鸟和恐龙的 time-spacedistribution 和放射上为学习有意义。 | ZHANG Lijun YANG Yajun ZHANG Lidong GUO Shengzhe WANG Wuli ZHENG Shaolin | 2007 | Acta Geologica Sinica(English Edition)2007，81，3： | 9 |
| 7 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 8 | Review on the NO removal from flue gas by oxidation methods显示文摘Due to the increasingly strict emission standards of NOx on various industries,many traditional flue gas treatment methods have been gradually improved.Except for selective catalytic reduction(SCR)and selective non-catalytic reduction(SNCR)methods to remove NOx from flue gas,theoxidation method is paying more attention to NOx removal now because of the potential to simultaneously remove multiple pollutants from flue gas.This paper summarizes the efficiency,reaction conditions,effect factors,and reaction mechanism of NO oxidation from the aspects of liquid-phase oxidation,gas-phase oxidation,plasma technology,and catalytic oxidation.The effects of free radicals and active components of catalysts on NO oxidation and the combination of various oxidation methods are discussed in detail.The advantages and disadvantages of different oxidation methods are summarized,and the suggestions for future research on NO oxidation are put forward at the end.The review on the NO removal by oxidation methods can provide new ideas for future studies on the NO removal from flue gas. | Meng Si Boxiong Shen George Adwek Lifu Xiong Lijun Liu Peng Yuan Hongpei Gao Cai Liang Qihai Guo | 2021 | Journal of Environmental Sciences2021，33，3： | 8 |
| 9 | How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes显示文摘在学习 mRNA 表示的一个关键假设是它在蛋白质表示的预言是增进知识的。然而,仅仅有限的研究在酵母探索了 mRNA 蛋白质表示关联或人的纸巾和结果是相对不一致的。我们从 30 个无关的女人在刚孤立的人的传播单核白血球在 mRNA 蛋白质表情上执行了关联分析。为 71 基因的表示蛋白质被确定并且由结合的 2-D 电气泳动识别了集体 spectrometry。相应 mRNA 表达式被 Affymetrix 基因芯片确定。重要关联(r=0.235, P < 0.0001 ) 包括所有学习基因和所有样品为整个数据集被观察。关联在基因本体论的不同生物范畴变化了。例如,最高的关联以细胞的部件为细胞外的区域的基因被完成(r=0.643, P < 0.0001 ) 并且最低关联为规定的基因被获得(r=0.099, P=0.213 ) 以生物过程。在染色体,样品的一半证明为 71 基因的重要积极关联和重要关联在所有样品在平均 mRNA 和平均蛋白质表示层次之间被发现(r=0.296, P < 0.01 ) 。在学习组水平,然而,仅仅五学习基因越过所有样品有重要积极关联。我们的结果显示出在 mRNA 和蛋白质表示层次之间的全面积极关联。然而,中等、变化的关联建议那 mRNA 表情可能有时是有用的,但是远非当然在预言蛋白质表示层次完善。 | Yanfang Guo Peng Xiao Shufeng Lei Feiyan Deng Gary Guishan Xiao Yaozhong Liu Xiangding Chen Liming Li Shan Wu Yuan Chen Hui Jiang Lijun Tan Jingyun Xie Xuezhen Zhu Songping Liang Hongwen Deng | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 7 |
| 10 | SnO_2 hollow spheres:Polymer bead-templated hydrothermal synthesis and their electrochemical properties for lithium storage显示文摘SnO2 hollow spheres have been synthesized via a facile hydrothermal method using sulfonated polystyrene beads as a template followed by a calcination process in air.X-ray diffraction,scanning electron microscopy,and transmission electron microscopy show that the as-obtained SnO2 hollow spheres have a wall thickness of about 50 nm,and consist of nanosized SnO2 particles with a mean diameter of about 15 nm.Electrochemical measurements indicate that the SnO2 hollow spheres exhibit improved electrochemical performance in terms of specific capacity and rate capability in comparison with commercial SnO2 when used as anode materials for lithium-ion batteries.The enhanced performance may be attributed to the spherical and hollow structure,as well as the building blocks of SnO2 nanoparticles. | YIN YaXia XIN Sen WAN LiJun LI CongJu GUO YuGuo | 2012 | Science China Chemistry2012，55，7： | 6 |
| 11 | Effect of Wuziyanzong pill on levels of sex hormones, and expressions of nuclear- associated antigen Ki-67 and androgen receptor in testes of young rats显示文摘OBJECTIVE: To evaluate the effects of Wuziyanzong pill on the levels of serum follicle stimulating hormone(FSH), luteinizing hormone(LH), testosterone(T) and the expressions of nuclear-associated antigen Ki67(Ki67), androgen receptor(AR) in testes of young rats.METHODS: Sixteen 20-day-old Wistar male rats were randomly divided into control and treatment group(n = 8). Rats in treatment group were administered Wuziyanzong pill by gavage; rats in control group administered the same volume of saline. After 10 days of treatment, the rats were killed, and then serum and testes were taken. The levels of FSH, LH and T were measured by radioimmunoassay(RIA). The histology of seminiferous tubule was observed by hematoxylin-eosin(HE) staining. The expression of Ki67 was detected by immunohistochemical assay(IHC). The m RNA level of Ki67, ARand CK-18 was detected with quantitative real-time polymerase chain reaction(Q-RT-PCR), the protein level of AR and CK-18 were tested by Western blot.RESULTS: Compared with control group, T level in treatment group increased significantly(P < 0.05).HE staining showed that both leydig cells and germ cells increased in treatment group. Expressions of Ki67 and AR became higher after treatment. There were no changes in CK-18 expression.CONCLUSION: Wuziyanzong pill can up-regulate AR level to promote germ cell proliferation and differentiation in young male rats. | He Mengmeng Wang Lijun Chen Yinghui Zhang Tingting Guo JianHe | 2016 | Journal of Traditional Chinese Medicine2016，36，6： | 6 |
| 12 | Adsorption of mercury on laterite from Guizhou Province,China显示文摘The adsorption behaviors of Hg(Ⅱ) on laterite from Guizhou Province,China,were studied and the adsorption mechanism was discussed.The results showed that different mineral compositons in the laterite will cause differences in the adsorption capacity of laterite to Hg(Ⅱ).Illite and non-crystalloids are the main contributors to enhancing the adsorption capacity of laterite to Hg(Ⅱ).The pH of the solution is an important factor affecting the adsorption of Hg(Ⅱ) on laterite.The alkalescent environment (pH 7-9) is favorable to the adsorption of Hg(Ⅱ).The amount of adsorbed Hg(Ⅱ) increases with increasing pH.When the pH reaches a certain value,the amount of the adsorbed Hg(Ⅱ) will reach the maximum level.The amount of adsorbed Hg(Ⅱ) decreases with increasing pH.The optimal pHs of laterite and kaolinite are 9 and 8,respectively.The optimal initial concentrations of Hg(Ⅱ) on laterite and kaolinite are 250 and 200 μg/ml,respectively.The adsorption isotherms were described by the Langmuir model.The adsorption of Hg(Ⅱ) on laterite is a quick process while that of Hg(Ⅱ) on kaolinite is a slow reaction.Laterite from Guizhou Province is a promising environmental material which can be used in the removal of Hg(Ⅱ) from wastewater. | Xiaohong YU Shouyang HE | 2008 | Journal of Environmental Sciences2008，20，11： | 6 |
| 13 | Rheological behaviors of coal slime produced by filter-pressing显示文摘It is an effective way to use coal slime as fuel for circulating fluidized bed boilers, which will not only solve its pollution to the environment, but also turn waste to treasure. In order to provide basic technical information for transportation of coal slime from the coal preparation plant to the boiler, this paper experimentally studied the rheological behaviors of coal slime produced by filter-pressing. By using a rotational viscometer, the influences of water content, temperature, and shear time on the rheological behaviors of coal slime were investigated. Experimental results show that the coal slime will behave like Bingham plastics with low water content and like Bingham pseudo-plastics with 37.5% water content,while like pseudo-plastics with 40% water content. This indicates that the water content of coal slime must be controlled in consideration of both transportation resistance and combustion efficiency. Study results also show that, the apparent viscosity of coal slime at 5℃ is about 1.5–1.7 times of that at 40℃ for water contents 32%–37.5%, while the influence of temperature can be neglected when the water content is 40%. With increasing of water content, the influences of shear time on the apparent viscosity of coal slime becomes less. When the water content is more than 30%, the effect of shear time is negligible. It indicates that water content has the most important influence on the rheological behaviors of coal slime. There must be an optimal water content in considering conveying resistance and combustion efficiency. The environmental temperature must also be considered in coal slime transportation. | Dai Zhaohui Shi Lele Wang Lijun Guo Chuwen | 2018 | International Journal of Mining Science and Technology2018，28，2： | 5 |
| 14 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 15 | Age-Related Reduction in Cortical Thickness in First-Episode Treatment-Na?ve Patients with Schizophrenia显示文摘Substantial evidence supports the neurodevelopmental hypothesis of schizophrenia.Meanwhile,progressive neurodegenerative processes have also been reported,leading to the hypothesis that neurodegeneration is a characteristic component in the neuropathology of schizophrenia.However,a major challenge for the neurodegenerative hypothesis is that antipsychotic drugs used by patients have profound impact on brain structures.To clarify this potential confounding factor,we measured the cortical thickness across the whole brain using highresolution T1-weighted magnetic resonance imaging in 145 first-episode and treatment-naive patients with schizophrenia and 147 healthy controls.The results showed that,in the patient group,the frontal,temporal,parietal,and cingulate gyri displayed a significant age-related reduction of cortical thickness.In the control group,age-related cortical thickness reduction was mostly located in the frontal,temporal,and cingulate gyri,albeit to a lesser extent.Importantly,relative to healthy controls,patients exhibited a significantly smaller age-related cortical thickness in the anterior cingulate,inferior temporal,and insular gyri in the right hemisphere.These results provide evidence supporting the existence of neurodegenerative processes in schizophrenia and suggest that these processes already occur in the early stage of the illness. | Yin Lin Mingli Li Yi Zhou Wei Deng Xiaohong Ma Qiang Wang Wanjun Guo Yinfei Li Lijun Jiang Xun Hu Nanyin Zhang Tao Li | 2019 | Neuroscience Bulletin2019，35，4： | 5 |
| 16 | Bionic surface design of cemented carbide drill bit显示文摘The development of a high-performance cemented carbide drill bit is of great significance to the reduction of rock drilling-cost. The non-smooth features of a biological surface provide an insight into how they can obtain low friction and good wear resistance with evolving surface morphology. By analyzing the mechanism of the surface of a dung beetle for reducing soil wear and adherence, we design a cemented carbide drill bit with a bionic surface, which is expected to have superior anti-wearing and anti-sticking properties for drilling the soft coal seam. Inspired from the characteristics of the head and pronotum surface of the dung beetle, optimized non-smooth surface of the drill bit was constructed. The working performance of this innovative drill was experimentally tested. With comparative experiments under the identical drilling conditions, the wear rates, drilling times of conventional drills and bionic drills were measured. Compared with the conventional counterpart, the drill designed exhibits better performance in reducing wear and sticking drilling-breaks, therefore achieving higher levels of efficiency. The diameter of the dome and pit on the bit surface is in the range of 0.8–1.2 mm, and the bionic drill bits could get better performance with preferable drilling speeds and wear rates. | YANG XiaoFeng XIA Re ZHOU HongWei GUO Lu ZHANG LiJun | 2016 | Science China(Technological Sciences)2016，59，1： | 4 |
| 17 | Mantle Branch Structure in the South-Central Segment of the Da Hinggan Mts.,Inner Mongolia and Its Ore-controlling Role显示文摘Mantle branch structure is the third tectonic unit of multiple evolution of a mantle branch. It is not only the main mechanism of intercontinental orogeny, but also an important ore-forming and ore-control structure. Studies on geotectonic evolution, regional geological characteristics and ore-forming and ore-control structures have shown that since the Mesozoic the Da Hinggan Mts. region has entered a typical intercontinental orogenic stage, and it is closely related to mantle branch activities. The south-central segment of the Da Hinggan Mts. is a typical mantle branch structure and possesses obvious magmatic-metamorphic complexes in the core, detachment slip beds in the periphery and overlapped fault depression basins. Moreover, all of these are the principal factors leading to ore formation and ore control in the region. This paper also further explores the mechanism of mineralization in the south-central segment of the Da Hinggan, summaries the rules of mineralization, puts forward the models of mineralization and points out future ore-exploring orientation. | NIU Shuyin SUN Aiqun WANG Baode NIE Fengjun JIANG Sihong SHAO Ji'an GUO Lijun LIU Jianming | 2009 | Acta Geologica Sinica(English Edition)2009，83，6： | 4 |
| 18 | Theoretical model of double-walled carbon nanotube pullout from a composite matrix显示文摘A micromechanical model of double-walled carbon nanotube (DWCNT) pullout from a composite matrix is presented with the interfacial residual stress and van der Waals (vdW) forces taken into consideration.The interfacial residual stress induced by thermal expansion coefficient (TEC) mismatch is introduced via thermo-elastic constitutive relations.The influence of vdW interactions between two layers of DWCNT on the interfacial stress distributions of DWCNT and matrix is analyzed.The analytical expressions of interfacial shear stress and the axial stresses of DWCNT and matrix are derived,respectively.Furthermore,the influences of temperature change,interfacial friction coefficient,DWCNT aspect ratio,DWCNT volume fraction and the relative modulus between DWCNT and matrix are illustrated and discussed. | ZHOU LiJun KANG YiLan GUO JianGang | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，6： | 4 |
| 19 | Frame synchronization for underwater acoustic communication based on maximum likelihood estimation显示文摘Traditional frame synchronization methods for underwater acoustic communication(UWAC) merely depend on correlation coefficient when synchronization signal detection is concerned and,hence,false triggering and missed synchronization can hardly be avoided in complex UWAC channels.In order to solve this problem,firstly,we analyze the effects of interference from noise,multipath and Doppler on frame synchronization;then we propose a new frame synchronization scheme based on parameter estimation.By exploiting the parameter estimation technique,we detect the synchronization signal according to the estimated parameters,thus the false triggering rate and missed synchronization rate can be reduced.We also simplify the maximum likelihood estimation to reduce computational cost.Simulation results indicate that this new scheme outperforms the traditional method in terms of delay resolution and correlation coefficient.Both static and mobile communication experimental results show that the correlation coefficient of the new scheme is higher than that of the traditional one.Moreover,the detection ability of the receiver is improved,which helps to avoid false triggering and missed synchronization. | GUO Zheng YAN Shefeng XU Lijun QIN Ye | 2016 | Chinese Journal of Acoustics2016，35，4： | 4 |
| 20 | Copy number variations of HLA-DRB5 is associated with systemic lupus erythematosus risk in Chinese Han population显示文摘全身的豺狼座 erythematosus (SLE ) 是复合基因,全身的、自体免疫的疾病。拷贝数字变体(CNVS ) 被发现了与很多复杂混乱被联系。我们拿了当前的学习在中国汉人口探索在 genomic CNVS 和 SLE 之间的潜在的协会。在发现阶段,七个 SLE 病人在屏蔽测试与高密度的比较 genomic 杂交 microarrays 被检查因为 SLE 联系了 CNVS。在确认阶段,然后, 135 个 SLE 病人和 219 个匹配的健康题目被 AccuCopy 技术为基因 HLA-DRB5 的 CNVS 调查。量的聚合酶链反应被执行在 SLE 病人决定拷贝数字(CN ) 和 HLA-DRB5 的 mRNA 水平。尽管在在 SLE 病人的 CN 删除组和 CN 正常的组之间的 HLA-DRB5 的 mRNA 水平不是统计上积极的( P = 0.46 ),我们的结果仍然比在健康控制在 SLE 病人显示出 HLA-DRB5 的更多的 CN ( P = 3.98 業慮瑮愠摮爠'酞棙M敶洠摯汥漠?偔?挠摯湯?′敷敲瀠牥潦浲摥?敲灳'虡N敶祬?剏?ㄠ????‥??ㄠ???劳?倠吗?? | Lijun Wu Shicheng Guo Dongqin Yang Yanyun Ma Hengdong Ji Yulin Chen Jun Zhang Yi Wang Li Jin Jiucun Wang Jie Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，2： | 3 |
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