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| 1 | A possible important CO_2 sink by the global water cycle显示文摘The locations,magnitudes,variations and mechanisms responsible for the global CO2 sink are uncer-tain and under debate.Here,we show,based on theoretical calculations and evidences from field monitoring results,that there is a possible important CO2 sink(as DIC-dissolved inorganic carbon)by the global water cycle.The sink constitutes up to 0.8013 Pg C/a(or 10.1% of the total anthropogenic CO2 emission,or 28.6% of the missing CO2 sink),and is formed by the CO2 absorption of water and subsequent enhanced consumption by carbonate dissolution and aquatic plant photosynthesis.Of the sink,0.5188 Pg C/a goes to sea via precipitation over sea(0.2748 Pg C/a)and continental rivers(0.244 Pg C/a),0.158 Pg C/a is released to the atmosphere again,and 0.1245 Pg C/a is stored in the continental aquatic ecosystem.Therefore,the net sink could be 0.6433 Pg C/a.This sink may increase with the global-warming-intensified global water cycle,the increase in CO2 and carbonate dust in atmosphere,and reforestation/afforestation,the latter increasing soil CO2,and thus the concentration of the DIC in water. | LIU ZaiHua Wolfgang DREYBRODT WANG HaiJing | 2008 | Chinese Science Bulletin2008，53，3： | 22 |
| 2 | A small natural molecule promotes mitochondrial fusion through inhibition of the deubiquitinase USP30显示文摘Mitochondrial 熔化是为正常 mitochondrial 功能和 mitochondrial DNA 继承混合并且统一 mitochondrial 分隔空间的一个高度协调的过程。Dysregulated mitochondrial 熔化原因 mitochondrial 破碎,反常 mitochondrial 生理学和继承,并且有原因地与很多 neuronal 疾病被连接了。这里,我们识别了 potently 导致了 mitochondrial 熔化在在 Mfn1 或 Mfn2 是缺乏的房间恢复 mitochondrial 网络和氧化呼吸的 diterpenoid 衍生物 15-oxospiramilactone (S3 ) 。线粒体局部性的 deubiquitinase USP30 是 S3 的一个目标。由 S3 的 USP30 的抑制导致 Mfn1/2 的 non-degradative ubiquitination 的增加,它提高 Mfn1 和 Mfn2 活动并且支持 mitochondrial 熔化。通过 USP30 的一个禁止者的使用,因此,我们的学习揭开在支持 mitochondrial 的 Mfns 的 non-degradative ubiquitination 的异乎寻常的功能熔化。 | Wen Yue Ziheng Chen HaiYang Li Chen Yan Ming Chen Du Feng Chaojun Yan Hao Wu Lei Du Yueying Wang Jinhua Liu Xiaohu Huang Laixin Xia Lei Liu Xiaohui Wang Haijing Jin Jun Wang Zhiyin Song Xiaojiang Hao Quan Chen | 2014 | Cell Research2014，24，4： | 18 |
| 3 | Beclin 1 cleavage by caspase-3 inactivates autophagy and promotes apoptosis显示文摘Autophagy and apoptosis are both highly regulated biological processes that play essential roles in tissue homeostasis,development and diseases.Autophagy is also described as a mechanism of death pathways,however,the precise mechanism of how autophagy links to cell death remains to be fully understood.Beclin 1 is a dual regulator for both autophagy and apoptosis.In this study we found that Beclin 1 was a substrate of caspase-3 with two cleavage sites at positions 124 and 149,respectively.Furthermore,the autophagosome formation occurred,followed by the appearance of morphological hallmarks of apoptosis after staurosporine treatment.The cleavage products of Beclin 1 reduced autophagy and promoted apoptosis in HeLa cells and the cells in which Beclin 1 was stably knocked down by specific shRNA.In addition,the cleavage of Beclin 1 resulted in abrogating the interaction between Bcl-2 with Beclin 1,which could be blocked by z-VAD-fmk.Thus,our results suggest that the cleavage of Beclin 1 by caspase-3 may contribute to inactivate autophagy leading towards augmented apoptosis. | Yushan Zhu Lixia Zhao Lei Liu Ping Gao Weili Tian Xiaohui Wang Haijing Jin Haidong Xu Quan Chen | 2010 | Protein & Cell2010，1，5： | 17 |
| 4 | Caspase cleavage of cytochrome cl disrupts mitochondrial function and enhances cytochrome c release显示文摘 | Yushan Zhu Min Li Xiaohui Wang Haijing Jin Shusen Liu Jianxin Xu Quan Chen | 2012 | Cell Research2012，22，1： | 6 |
| 5 | Rational design of novel ultra-small amorphous Fe_(2)O_(3)nanodots/graphene heterostructures for all-solid-state asymmetric supercapacitors显示文摘Constructing graphene-based heterostructures with large interfacial area is an efficient approach to enhance the electrochemical performance of supercapacitors but remains great challenges in their synthesis.Herein,a novel ultra-small amorphous Fe_(2)O_(3)nanodots/graphene heterostructure(a-Fe_(2)O_(3)NDs/RGO)aerogel was facilely synthesized via excessive metal-ion-induced self-assembly and subsequent calcination route using Prussian blue/graphene oxide(PB/GO)composite aerogel as precursors.The deliberately designed a-Fe_(2)O_(3)NDs/RGO heterostructure offers a highly interconnected porous conductive network,large heterostructure interfacial area,and plenty of accessible active sites,greatly facilitating the electron transfer,electrolyte diffusion,and pseudocapacitive reactions.The obtained a-Fe_(2)O_(3)NDs/RGO aerogel could be used as flexible free-standing electrodes after mechanical compression,which exhibited a significantly enhanced specific capacitance of 347.4 F·g^(-1)at 1 A·g^(-1),extraordinary rate capability of 184 F·g^(-1)at 10 A·g^(-1),and decent cycling stability.With the as-prepared a-Fe_(2)O_(3)NDs/RGO as negative electrodes and the Co_(3)O_(4)NDs/RGO as positive electrodes,an all-solid-state asymmetric supercapacitor(a-Fe_(2)O_(3)NDs/RGO//Co_(3)O_(4)NDs/RGO asymmetric supercapacitor(ASC))was assembled,which delivered a high specific capacitance of 69.1 F·g^(-1)at 1 A·g^(-1)and an impressive energy density of 21.6 W·h·k·g^(-1)at 750 W·k·g^(-1),as well as good cycling stability with a capacity retention of 94.3%after 5,000 cycles.This work provides a promising avenue to design high-performance graphene-based composite electrodes and profound inspiration for developing advanced flexible energy-storage devices. | Chenxiao Wu Zhifang Zhang Zhonghui Chen Zuimin Jiang Huiyu Li Haijing Cao Yongsheng Liu Yanyan Zhu Zebo Fang Xiangrong Yu | 2021 | Nano Research2021，14，4： | 6 |
| 6 | An effective poly(p-phenylenevinylene) polymer adhesion route toward three-dimensional nitrogen-doped carbon nanotube/reduced graphene oxide composite for direct electrocatalytic oxygen reduction显示文摘做 Heteroatom 的 nanocarbons 在氧减小反应(ORR ) 为使用有优秀潜力。然而,建设三维(3D ) 有好 electrocatalytic 表演遗体的做 N 的碳材料挑战。此处,一(p-phenylenevinylene )(PPV ) poly,先锋粘附线路为 3D 的建设被开发做 N 的减少的 graphene oxide-PPV 锻烧碳的 nanotubes (N-RGO-PPV (c)-CNTs) 。在合成, PPV 先锋为 RGO 和 CNT 的强壮的粘附起胶水的作用。在高温度, PPV 能从玻璃质的状态经历转变到一粘滞状态。因此,与多多孔的结构合成、如脊的 N-RGO-PPV (c)-CNT 合拢了 graphene 薄片能在高温度在 nitridation 期间被形成,它为为 ORR 的更活跃的地点的生产是有利的。作为 ORR 催化剂, N-RGO-PPV (c)-CNT composites 在碱的电解质展出了优异催化活动。获得的发作潜力(E 0.92 V 和 5.7 mAe 的催化当前的密度的发作 ) 并且最大化空间利用。有五的 DI-TENG 在 12 厘米物浥湥?景愠氠睯漠敶灲瑯湥楴污漠?的体积重复了单位??噭琠?捡楨癥??‰?敬畣慬?敤潳灲楴湯?硅数楲敭瑮污祬洠慥?敲?楤晦牥湥楴污眠牯?畦据楴湯愠??畦据楴湯漠?整灭牥瑡牵?桳睯?敤潳灲楴湯瀠慥獫愠??愠摮????桴楥?汥'虪罐嫖蹫u潲数瑲敩?桳睯朠敲瑡瀠瑯湥楴污映牯爠慥?楴敭?湩猠瑩?潭楮潴楲杮漠?潭敬畣慬?摡潳灲楴湯愠摮搠獥牯瑰潩??瑬潨杵?桴?潭敬畣慬?摡潳灲楴湯椭摮'讚涌畺{?湩琠敨攠敬瑣潲楮?潷歲映湵瑣潩?獩瘠牥?敳獮瑩癩?椠?潤獥渠瑯栠癡?湡?...?睯癥牥?桴?整灭牥瑡牵?敤数摮湥祣漠?桴? | Yu Fu Chungui Tian Fangyuan Liu Lei Wang Haijing Yan Bai Yang | 2016 | Nano Research2016，9，11： | 3 |
| 7 | Woody species Rhus chinensis Mill. seedlings tolerance to Pb:Physiological and biochemical response显示文摘Screening potential plant species is a crucial consideration in phytoremediation technology.Our previous study demonstrated that Rhus chinensis Mill. seedlings had potentials for phytoremediation of Pb contaminated soil. However, its bioaccumulation and tolerance characteristics remain unclear. Seedling growth, LMWOAs secreted by roots, Pb subcellular distribution and chemical forms, and mineral elements in R. chinensis tissues were evaluated under different Pb concentrations(0, 25, 50, 100, 200 and 400 mg/L) in culture solution at14 days after planting. R. chinensis did not show visual symptoms of Pb toxicity under lower Pb treatments; however, Pb significantly declined the growth of seedlings under higher Pb treatments. Higher Pb stress also decreased the concentrations of nitrogen in leaves, but increased the concentrations of P and K in roots. Pb stress also decreased Mn concentrations in leaves. A great quantity of Pb was uptake and mostly retained in R. chinensis roots.Nonetheless, R. chinensis can still concentrate 459.3 and 1102.7 mg/kg Pb in leaves and stems,respectively. Most of Pb in R. chinensis tissues was stored in the cell wall with HAc-, HCl-, and NaC l-extractable form. LMWOAs secreted by R. chinensis roots showed a strong positive correlation with Pb concentrations in all plant tissues and with P in roots. Our results suggested that Pb deposited in the cell wall and integration with phosphate or oxalate might be responsible for the tolerance of R. chinensis under Pb stress in short period. | Xiang Shi Shufeng Wang Dongxue Wang Haijing Sun Yitai Chen Jianfeng Liu Zeping Jiang | 2019 | Journal of Environmental Sciences2019，31，4： | 3 |
| 8 | Detection of mycobacterial and viral DNA in Kikuchi-Fujimoto disease: an analysis of 153 Chinese pediatric cases显示文摘Dear Editor,Kikuchi-Fujimoto disease(KFD),or histiocytic necrotizing lymphadenitis,was initially described in 1972 by Drs.Kikuchi and Fujimoto(Shirakusa et al.,1988).The main clinical manifestations are fever and cervical lymphadenopathy with or without pain,sometimes accompanied by tachycardia,nausea and symptomatic infiltrative erythematous lesions.The diagnosis of KFD is usually based on characteristic lymph node histologic findings of coagulative necrosis,histiocytic infiltrate,loss of nodal architecture, | Zhe Xu Ying Liu Haijing Li Shufang Meng Alan S.Boyd Charles W.Stratton Lin Ma Yi-Wei Tang | 2017 | Science China(Life Sciences)2017，60，7： | 2 |
| 9 | The confined growth of few-layered and ultrashort-slab Ni-promoted MoS_(2)on reduced graphene oxide for deep-degree hydrodesulfurization显示文摘Hydrodesulfurization(HDS)is an essential process in clean fuel oil production,however,the huge challenge is the synthesis of the catalyst with plentiful active sites.Here,we have shown the design of few-layered,ultrashort Ni-Mo-S slabs dispersed on reduced graphene oxide(Ni-Mo-S/rGO-A)based on anchoring[PMo_(12)O_(40)]3−clusters and Ni^(2+)on polyethyleneimine(PEI)-modified graphite oxide.Structural characterizations(transmission electron microscopy(TEM),X-ray absorption fine structure(XAFS),etc.)show that Ni-Mo-S slabs with predominant monolayer and partial substitution of edge Mo atoms by isolated Ni atoms have rich accessible edge Ni-Mo-S sites and high sulfurization degree.All virtues endow it with plentiful edge-active sites,and consequently,the enhanced performance for hydrodesulfurization of dibenzothiophene(DBT).The hydrodesulfurization proceeds via a more-favorable direct desulfurization(DDS)route with a reaction rate constant(kHDS)of 48.6×10^(−7)mol·g^(−1)·s^(−1)over Ni-Mo-S/rGO-A catalyst,which is 4.3 times greater than that over traditional Ni-Mo-S/Al_(2)O_(3)catalyst and at the forefront of reported catalysts. | Dongxu Wang Lei Wang Yanqing Jiao Aiping Wu Haijing Yan Xin Kang Chungui Tian Jiancong Liu Honggang Fu | 2022 | Nano Research2022，15，8： | 2 |
| 10 | Spectrum of EGFR aberrations and potential clinical implications:insights from integrative pan-cancer analysis显示文摘Background:Human epidermal growth factor receptor(EGFR)is an oncogenic gene and one of top targets of precision therapy in lung cancer with EGFR mutations.Although there are many reports for some individual cancers,comprehensive profiling of EGFR mutations,overexpression,amplification,DNA methylation,and their clinical associations across many different cancers simultaneously was not available.This study aimed to fill the gap and provide insights to the alteration spectrum of EGFR and its therapeutic and prognostic implications.Methods:The Cancer Genome Atlas(TCGA)datasets for 32 cancer types involving 11,314 patients were analyzed for alterations(mutations and amplification/deletion),abnormal expression and DNA methylation in EGFR gene.Mutation frequency,genomic location distribution,functional impact,and clinical targeted therapy implication were compared among different cancer types,and their associations with patient survival were analyzed.Results:EGFR alteration frequency,mutation sites across functional domains,amplification,overexpression,and DNA methylation patterns differed greatly among different cancer types.The overall mutation frequency in all cancers combined was relatively low.Targetable mutations,mainly in lung cancer,were primarily found in the Pkinase_Tyr domain.Glioblastoma multiforme had the highest rate of alterations,but it was dominated by gene amplification and most mutations were in the Furin-like domain where targeted therapy was less effective.Low-grade glioma often had gene amplification and increased EGFR expression which was associated with poor outcome.Colon and pancreatic adenocarcinoma had very few EGFR mutations;however,high EGFR expression was significantly associated with short patient survival.Squamous cell carcinoma regardless of their sites(the head and neck,lung,or esophagus)exhibited similar characteristics with an alteration frequency of about 5.0%,was dominated by gene amplification,and had increased EGFR expression generally associated with short patient survival.DNA methylation was highly associated with EGFR expression and patient outcomes in some cancers.Conclusions:EGFR aberration type,frequency,distribution in functional domains,and expression vary from cancer to cancer.While mutations in the Pkinase_Tyr domain are more important for treatment selection,increased expression from amplification or deregulation affects more tumor types and leads to worse outcome,which calls for new treatment strategies for these EGFR-driven tumors. | Haijing Liu Bo Zhang Zhifu Sun | 2020 | Cancer Communications2020，40，1： | 2 |
| 11 | Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances显示文摘Background Working memory(WM)deficit is considered a core feature and cognitive biomarker in patients with schizophrenia.Several studies have reported prominent object WM deficits in patients with schizophrenia,suggesting that visual WM in these patients extends to non-spatial domains.However,whether non-spatial WM is similarly affected remains unclear.Aim This study primarily aimed to identify the processing of visual object WM in patients with first-episode schizophrenia.Methods The study included 36 patients with first-episode schizophrenia and 35 healthy controls.Visual object WM capacity,including face and house WM capacity,was assessed by means of delayed matching-to sample visual WM tasks,in which participants must distribute memory so that they can discriminate a target sample.We specifically examined their anhedonia experience by the Temporal Experience of Pleasure Scale and the Snaith-Hamilton Pleasure Scale.Cognitive performance was measured by the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).Results Both face and house WM capacity was significantly impaired in patients with schizophrenia.For both tasks,the performance of all the subjects was worse under the high-load condition than under the low-load condition.We found that WM capacity was highly positively correlated with the performance on RBANS total scores(r=−0.528,p=0.005),RBANS delayed memory scores(r=−0.470,p=0.013),RBANS attention scores(r=−0.584,p=0.001),RBANS language scores(r=−0.448,p=0.019),Trail-Making Test:Part A raw scores(r=0.465,p=0.015)and simple IQ total scores(r=−0.538,p=0.005),and correlated with scores of the vocabulary test(r=−0.490,p=0.011)and scores of the Block Diagram Test(r=−0.426,p=0.027)in schizophrenia.No significant correlations were observed between WM capacity and Positive and Negative Syndrome Scale symptoms.Conclusions Our research found that visual object WM capacity is dramatically impaired in patients with schizophrenia and is strongly correlated with other measures of cognition,suggesting a mechanism that is critical in explaining a portion of the broad cognitive deficits observed in schizophrenia. | Yi Liu Taiyong Bi Bei Zhang Qijie Kuang Haijing Li Kunlun Zong Jingping Zhao Yuping Ning Shenglin She Yingjun Zheng | 2021 | General Psychiatry2021，34，1： | 2 |
| 12 | Molecular biological analysis of remains from Jiangjungou Cemetery in Inner Mongolia显示文摘在亢奋的可变区域的 364-bp 核苷酸顺序(HVRI ) 我成功地从在始于的内部蒙古在 Jiangjungou 公墓埋葬的一张古老的人口的 11 个个人从 9 mitochondrial DNA 被放大在中国的打仗的状态时期。有不同变化的九碎片被获得。种系发生的树并且多维的可伸缩(MDS ) 阴谋的 A 从古老的人口和几张现代亚洲人口用 mtDNA 序列被构造。结果证明那张古老的人口与东方亚洲人口分享一种更近基因的关系那与诺思和中央亚洲人口一起。基因、历史的证据提起人口可能是来自 Zhongyuan 区域的移民的可能性,由赵状态的伍灵国王送了从匈奴对攻击看守国家。 | WANG Haijing LIU Weiqiang FU Yuqin ZHANG Xiaolei ZHOU Hui ZHU Hong | 2006 | Progress in Natural Science:Materials International2006，16，7： | 2 |
| 13 | Evaluation of menopausal status among breast cancer patients with chemotherapy-induced amenorrhea显示文摘Objective: In patients with chemotherapy-induced amenorrhea(CIA), the menopausal status is ambiguous and difficult to evaluate. This study aimed to establish a discriminative model to predict and classify the menopausal status of breast cancer patients with CIA.Methods: This is a single center hospital-based study from 2013 to 2016. The menopausal age distribution and accumulated incidence rate of CIA are described. Multivariate models were adjusted for established and potential confounding factors including age, serum concentration of estradiol(E2) and follicle-stimulating hormone(FSH),feeding, pregnancy, parity, abortions, and body mass index(BMI). The odds ratio(OR) and 95% confidence interval(95% CI) of different risk factors were estimated.Results: A total of 1,796 breast cancer patients were included in this study, among whom, 1,175(65.42%) were premenopausal patients and 621(34.58%) were post-menopause patients. Five hundred and fifty patients were included in CIA analysis, and a cumulative CIA rate of 81.64% was found in them. Age(OR: 1.856, 95% CI:1.732-1.990), serum concentration of E2(OR: 0.976, 95% CI: 0.972-0.980) and FSH(OR: 1.060, 95% CI:1.053-1.066), and menarche age(OR: 1.074, 95% CI: 1.009-1.144) were found to be associated with the patients' menopausal status. According to multivariate analysis, the discriminative model to predict the menopausal status is Logit(P)=-28.396+0.536 Age-0.014 E2+0.031 FSH. The sensitivities for this model were higher than 85%, and its specificities were higher than 89%.Conclusions: The discriminative model obtained from this study for predicting menstrual state is important for premenopausal patients with CIA. This model has high specificity and sensitivity and should be prudently used. | Bailin Zhang Jinqi Wu Rongshou Zheng Qian Zhang Margaret Zhuoer Wang Jun Qi Haijing Liu Yipeng Wang Yang Guo Feng Chen Jing Wang Wenyue Lyu Jidong Gao Yi Fang Wanqing Chen Xiang Wang | 2018 | Chinese Journal of Cancer Research2018，30，4： | 2 |
| 14 | Carbon-Coated Li4Ti5O12 As A High Rate Electrode Material for Li-Ion Intercalation 显示文摘 | CHENG Liang LI Xili LIU Haijing | 2007 | Journal of Electrochemical Society2007，154，7： | 1 |
| 15 | Highly active porous nickel-film electrode via polystyrene microsphere template-assisted composite electrodeposition for hydrogen-evolution reaction in alkaline medium显示文摘A highly porous nickel-film electrode with satisfactory mechanical strength was prepared by a facile vertical template-assisted composite electrodeposition method using polystyrene(PS) microspheres templates, with the aim of improving the electrocatalytic activity for the hydrogen-evolution reaction(HER). During the composite electrodeposition process, the hydrophobic PS microspheres were highly dispersed in the electrolyte with the help of a surfactant, and then co-deposited with Ni to form the film electrode. After removing the PS templates by annealing, a porous Ni film containing large amount of uniformly dispersed pores with narrow size distribution was obtained, and then applied as the electrode for the HER in an alkaline medium. As evidenced by the electrochemical analysis, the porous Ni film electrode exhibits higher catalytic activity as compared to a dense Ni film electrode and is superior to a Ni/Ru O2/Ce O2 commercial electrode. The effect of temperature on the catalytic properties of the porous Ni film electrode was also investigated; the activation energy was calculated as 17.26 k J/mol. The enhanced activity toward the HER was attributed to the improved electrochemical surface area and mass transportation facilitated by the high porosity of the synthesized Ni film electrode. | Yinliang Cao Haijing Liu Xin Bo Feng Wang | 2015 | Science China Chemistry2015，58，3： | 1 |
| 16 | A new directionin effective accounting for the atmospheric CO2 budget: Consid- ering the combined action of carbonate dissolution, the global water cycle and photosynthetic uptake of DIC by aquatic organ- isms显示文摘 | LIU Zaihua WOLFGANG D WANG Haijing | 2010 | Earth Science Reviews2010，99，3： | 1 |
| 17 | Nanosized Li4Ti5O12 prepared by molten salt method as an electrode material for hybrid electrochemical supercapacitors显示文摘 | Cheng L Liu Haijing Zhang Jingjun | 2006 | J Eleetrochem Soc2006，1538，： | 1 |
| 18 | A new direc- tion in effective accounting for the atmospheric CO2 budget: Considering the combined action of carbonate dissolution, the global water cycle and photosynthetic uptake of DIC by aquatic organisms 显示文摘 | Zaihua Liu Wolfgang Dreybrodt Haijing Wang | 2010 | Earth-Science Reviews2010，99，： | 1 |
| 19 | Nanosized Li4 Ti5 O12 prepared by molten salt as an electrode material for hybrid electrochemical supercapacitor显示文摘 | Cheng Liang Liu Haijing Zhang Jinjun | 2006 | J Electrochem Soc2006，153，8： | 1 |
| 20 | Alternations in the gut microbiota and metabolome with newly diagnosed unstable angina显示文摘Gut microbiota plays an important role in coronary heart disease, but its compositional and functional changes in unstable angina(UA) remain unexplored. We performed metagenomic sequencing of 133 newly diagnosed UA patients and 133 sex-and age-matched controls, and profiled the fecal and plasma metabolomes in 30 case-control pairs. The alpha diversity of gut microbiota was increased in UA patients:the adjusted odds ratios(ORs) per standard deviation increase in Shannon and Simpson indices were 1.30(95% confidence interval, 1.01-1.70) and 1.36(1.05-1.81), respectively. Two common species(depleted Klebsiella pneumoniae and enriched Streptococcus parasanguinis;P ≤ 0.002) and three rare species(depleted Weissella confusa, enriched Granulicatella adiacens and Erysipelotrichaceae bacterium 6_1_45;P ≤ 0.005) were associated with UA. The UA-associated gut microbiota was depleted in the pathway of Lphenylalanine degradation(P = 0.001), primarily contributed by Klebsiella pneumoniae. Consistently, we found increased circulating phenylalanine in UA patients(OR = 2.76 [1.17-8.16]). Moreover, Streptococcus parasanguinis was negatively correlated with fecal citrulline(Spearman's r_(s)=-0.470, P = 0.009), a metabolite depleted in UA patients(OR = 0.26 [0.08-0.63]). These findings are informative to help understand the metabolic connection between gut microbiota and UA. | Xuezhen Liu Miaoyan Shen Han Yan Pinpin Long Haijing Jiang Yizhi Zhang Lue Zhou Kuai Yu Gaokun Qiu Handong Yang Xiulou Li Xinwen Min Meian He Xiaomin Zhang Hyungwon Choi Chaolong Wang Tangchun Wu | 2022 | Journal of Genetics and Genomics2022，49，3： | 1 |
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