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| 1 | Integrative lipidomic and transcriptomic study unravels the therapeutic effects of saikosaponins A and D on non-alcoholic fatty liver disease显示文摘Nonalcoholic fatty liver disease(NAFLD)has become one of the most prominent causes of chronic liver diseases and malignancies.However,few therapy has been approved.Radix Bupleuri(RB)is the most frequently used herbal medicine for the treatment of liver diseases.In the current study,we aim to systemically evaluate the therapeutic effects of saikosaponin A(SSa)and saikosaponin D(SSd),the major bioactive monomers in RB,against NAFLD and to investigate the underlying mechanisms.Our results demonstrated that both SSa and SSd improved diet-induced NAFLD.Integrative lipidomic and transcriptomic analysis revealed that SSa and SSd modulated glycerolipid metabolism by regulating related genes,like Lipe and Lipg.SSd profoundly suppressed the fatty acid biosynthesis by downregulating Fasn and Acaca expression and promoted fatty acid degradation by inducing Acox1 and Cpt1 a expression.Bioinformatic analysis further predicted the implication of master transcription factors,including peroxisome proliferator-activated receptor alpha(PPARα),in the protective effects of SSa and SSd.These results were further confirmed in vitro in mouse primary hepatocytes.In summary,our study uncoded the complicated mechanisms underlying the promising anti-steatosis activities of saikosaponins(SSs),and provided critical evidence inspiring the discovery of innovative therapies based on SSa and SSd for the treatment of NAFLD and related complications. | Xiaojiaoyang Li Junde Ge Yajing Li Yajie Cai Qi Zheng Nana Huang Yiqing Gu Qi Han Yunqian Li Rong Sun Runping Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 15 |
| 2 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 3 | Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering显示文摘Dear Editor,Type1diabetes(T1D)isa lifelong(chronic)disease and a major health problem throughout the world.This disease can be treatedby either insulin injection or islet transplantation.Islet transplantation is considered as a better treatment for T1D patients,because islets can produce and release insulin at the appropriate time,resulting in tight blood glucose control. | Yi Yang Kepin Wang Han Wu Qin Jin Degong Ruan Zhen Ouyang Bentian Zhao Zhaoming Liu Yu Zhao Quanjun Zhang Nana Fan Qishuai Liu Shimei Guo Lei Bu Yong Fan Xiaofang Sun Xiaoping Li Liangxue Lai | 2016 | Journal of Molecular Cell Biology2016，8，2： | 6 |
| 4 | Laser dissimilar welding of CoCrFeMnNi-high entropy alloy and duplex stainless steel显示文摘High entropy alloys(HEAs)have superior mechanical properties that have enabled them to be used as structural materials in nuclear and aerospace applications.As a dissimilar joint design is required for these applications,we created a dissimilar joint between CoCrFeMnNi-HEA and duplex stainless steel(DSS)through laser beam welding;a technique capable of producing a sound joint between the two materials.Micro structure examination using SEM/EBSD/XRD analysis revealed that the weld metal(WM)exhibits an FCC phase regardless of the postweld heat treatment(PWHT)temperature(800 and 1000℃)without forming detrimental intermetallic compounds or microsegregation.The heat-affected zone of the CoCrFeMnNi-HEA showed CrMn oxide inclusions while that of the DSS showed no inclusions.Moreover,a lower hardness was recorded by the WM compared to the base metal after welding.After PWHT,the hardness of the WM,CoCrFeMnNi-HEA,and DSS decreased with an increase in the PWHT temperature.However,the decrease in the hardness of the HEA was more significant than in the WM and DSS.The cause for this reduction in hardness was attributed to recrystallization and grain growth.In addition,a strength of 584 MPa with low ductility was recorded after welding.The obtained strength was lower than that of the BMs,but comparable to that of the welded CoCrFeMnNi-HEA.The application of PWHT resulted in over a 20%increment in ductility,with only a marginal reduction in strength.The defo rmation mechanism in the as-weld joint was mainly dominated by dislocation while that for the PWHT joint was twinning.We propose laser beam offset welding as a technique to improve the mechanical properties of the dissimilar joint,which will be the subject of future studies. | Nana Kwabena Adomako Giseung Shin Nokeun Park Kyoungtae Park Jeoung Han Kim | 2021 | Journal of Materials Science & Technology2021，，26： | 6 |
| 5 | Janus electrode with simultaneous management on gas and liquid transport for boosting oxygen reduction reaction显示文摘Oxygen reduction efficiency holds the key for renewable energy technologies including fuel cells and metal-air batteries,which involves coupling diffusion-reaction-conduction processes at the interface of catalyst/electrolyte,and thus rational electrode design facilitating mass transportation stands as a key issue for fast oxygen reduction reaction(ORR).Herein,we report a Janus electrode with asymmetric wettability prepared by partly modifying aerophobic nitrogen doped carbon nanotube arrays with polytetrafluoroethylene(PTFE)as a high performance catalytic electrode for ORR.The Janus electrode with opposite wettability on adjacent sides maintains stable gas reservoir in the aerophilic side while shortening O2 pathway to catalysts in the aerophobic side,resulting in superior ORR performance(22.5 mA/cm^2@0.5 V)than merely aerophilic or aerophilic electrodes.The Janus electrode endows catalytic performance even comparable to commercial,Pt/C in the alkali ne electrolyte,exploiting a previously unrecognized opport unity that guides electrode design for the gas-consumption electrocatalysis. | Yingjie Li Haichuan Zhang Nana Han Yun Kuang Junfeng Liu Wen Liu Haohong Duan Xiaoming Sun | 2019 | Nano Research2019，12，1： | 4 |
| 6 | Nosema bombycis (Microsporidia) suppresses apoptosis in BmN cells (Bombyx mori)显示文摘Nosema bombycis (N。bombycis, Nb ) 一真菌相关并且要求在蚕引起长期的蚕胞子虫病疾病的细胞内部的寄生虫。在感染主人以后,孢子从主人房间获得精力并且幸存几天。在病原体和宿主细胞之间的这共生建议那 N。bombycis 阻止 apoptosis 和宿主细胞的反应的氧种(ROS ) 生产为它的生长和发展创造最佳的环境条件。在这研究,不同方法被用来证明那 N。bombycis 在 BmN 房间压制了 apoptosis。流动 cytometry 分析结果证明孢子在感染以后在 2 和 5 天压制了 BmN 房间的 apoptosis (P < 0.05 ) 。与放线菌素 D (ActD ) 处理相比, BmN 房间的 apoptosis 显然在孢子感染以后被减少(P < 0.01 ) 。在感染以后的 48 个小时, BmN 房间的 ROS 生产在为 6 h 的 ActD 处理以后与那相比是下面调整的。而且, N。bombycis 阻止了 apoptosomes 的形成由下面调整 apaf-1 和细胞色素 C 的表示。另外, N。bombycis 也起来调整 buffy 的表示。西方的污点分析证明孢子减少了在 48 和 98 h 柱子感染的主人细胞色素 C 的水平。因此,我们的结果建议了那 N。bombycis 禁止了主人房间的 mitochondrial apoptotic 小径为它的自己的幸存创造最佳的环境。 | Xinyi He Zhangwuke Fu Mingqian Li Han Liu Shunfeng Cai Nana Man Xingmeng Lu | 2015 | Acta Biochimica et Biophysica Sinica2015，47，9： | 4 |
| 7 | Microbial diversity and functionally distinct groups in produced water from the Daqing Oilfield,China显示文摘The microbial community structure and functionally distinct groups in three kinds of produced water samples from the shallow,mesothermic and low-salinity Daqing oil reservoir were systematically evaluated using both culture-dependent and culture-independent methods.Sequence analysis of the 16S rRNA genes indicated that the bacterial library was dominated by Acinetobacter and Arcobacter and the archaeal community was dominated by Methanosaeta and Methanolinea.Two isolated methanogens were closely related with Methanothermobacter thermautotrophicus and Methanoculleus receptaculi.The fermentative bacteria were identified as Pseudomonas,Haloanaerobium,Alcalibacter,Arcobacter,and Pannonibacter.The predominant nitrate-reducing bacteria fell within the genus Pseudomonas.The dominant members of the cultured hydrocarbon-oxidizing bacteria were phylogenetically associated with Micrococcus,Pseudomonas,and Bacillus.Enrichments of biosurfactants and biopolymer producing groups mainly yielded Pseudomonas,Bacillus,and Acenitobacter-related members.The functional groups related to polymer degradation were also affiliated with Pseudomonas and Bacillus.Results from this study provide the fresh insight into the diversity of microbial communities in Daqing petroleum reservoirs.The vast pool of functional strains retrieved in this study was presumed to include the promising strains that could be applied in microbial-enhanced oil recovery in future. | Li Hui Ai Mingqiang Han Siqin Guo Yanling Li Nana Shi Rongjiu Zeng Xiangling Leng Shengbing Zhao Jinyi Liu Xiaobo Zhang Ying | 2012 | Petroleum Science2012，9，4： | 3 |
| 8 | Highly efficient and stable solar-powered desalination by tungsten carbide nanoarray film with sandwich wettability显示文摘Solar-powered desalination is a promising way to resolve the worldwide water crisis for its low con- sumption and simple facility. Considering the fragility and aggregations of traditional materials, which may decrease efficiency, we herein introduce a robust tungsten carbide (WC) nanoarray film as a stable and efficient photothermal material, whose absorption is over 97.5% throughout almost the whole solar spectrum range (220–2200 nm) due to nanoarray structure and thus enhanced localized surface plasmon resonance. Besides, for the first time, we modified the film with sandwich wettability. It accelerates evap- oration by reducing water’s reflection of light, enlarging hydrophobic-hydrophilic boundaries, and depressing heat dissipation. Combining high absorption with unique wettability, the WC nanoarray film offers high solar-to-vapor efficiency of 90.8% and produces drinking water at the rate of (1.06 ± 0.10) kg m^(-2)h^(-1)from man-made seawater and (0.98 ± 0.18) kg m^(-2)h^(-1)from heavy metal sewage under one sun (AM 1.5) while 98% performance remains after 1 h×100 times’ reutilization. | Nana Han Kai Liu Xinping Zhang Meng Wang Pan Du Zhaohui Huang Daojin Zhou Qian Zhang Tengfei Gao Yin Jia Liang Luo Jianjun Wang Xiaoming Sun | 2019 | Science Bulletin2019，64，6： | 2 |
| 9 | Development and validation of a TaqMan^(TM) fluorescent quantitative real-time PCR assay for the rapid detection of Edwardsiella tarda显示文摘Edwardsiella tarda is one of the most important emerging pathogens in the global aquaculture industries. As such, an accurate diagnosis and quantitative analytical methods are urgently needed for this bacterium. In this study, primers and a TaqMan probe specific to the conservative sequences of the 16S rRNA gene of E. tarda were designed. The concentration of primers and TaqMan probe were optimized to 200 nmol/L and 120 nmol/L, respectively. The detection sensitivity of the FQ-PCR assay was determined to be as low as five copies of the target sequence per reaction using the pGEM-16S rDNA recombinant plasmid as a template, which was 100 times more sensitive than conventional PCR. A standard curve by plotting the threshold cycle values (y) against the common logarithmic copies (log_10 n_c as x; n_c is copy number) of pGEM-16S rDNA was generated. The results of intra-and inter-assay variability tests demonstrate that the established FQ-PCR method was highly reproducible. The assay was specific for E. tarda as it showed that there was no cross-reactivity to eight additional bacterial pathogen strains in aquaculture. Thus, the FQ-PCR assay has the potential for diagnostic purposes and for other applications, especially for the rapid detection and quantification of low-grade E. tarda infections. | XIE Guosi HUANG Jie ZHANG Qingli HAN Nana SHI Chengyin WANG Xiuhua | 2012 | Acta Oceanologica Sinica2012，31，4： | 2 |
| 10 | 长链非编码RNA在肿瘤中的研究(英文)显示文摘Long non-coding RNAs(lncRNAs), gradually being paid attention to, have been found playing a critical role in regulation of cellular processes such as cell growth and apoptosis, what is more, accumulating evidence indicates that lncRNAs also play a critical role in regulation of carcinogenesis and cancer progression. Here, we will summarize the recent researches about some lncRNAs in the development of cancers, hoping to give a new view about the study in the mechanisms involved in carcinogenesis and tumor progression. | Tingting Yu Ximing Xu Yi Hu Junjian Deng Biao Chen Nana Han Meixia Zhang | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，1： | 1 |
| 11 | Phenylfluorenamine-functionalized poly(N-vinylcarbazole)s as dopant-free polymer hole-transporting materials for inverted quasi-2D perovskite solar cells显示文摘In order to improve the efficiency and stability of inverted three-dimensional(3D) or quasi-2D perovskite solar cells(PSCs) for future commercialization, exploring high efficient dopant-free polymer holetransporting materials(HTMs) is still desired and meaningful. One simple and efficient way to achieve high performance dopant-free HTMs is to synthesize novel non-conjugated side-chain polymers via rational molecular design. In this work, N-(4-methoxyphenyl)-9,9-dimethyl-9H-fluoren-2-amine(FMeNPh) groups are introduced into the poly(N-vinylcarbazole)(PVK) side chains to afford two nonconjugated polymers PVCz-DFMeNPh and PVCz-FMeNPh as dopant-free HTMs in inverted quasi-2D PSCs. Benefited from the flexible properties of polyethylene backbone and excellent optoelectronic natures of FMeNPh side-chain groups, PVCz-DFMeNPh with more FMeNPh units exhibited excellent thermal stability, well-matched energy levels and improved charge mobility as compared to PTAA and PVCzFMeNPh. Moreover, the morphologies investigation of quasi-2D perovskite on PVCz-DFMeNPh shows more compact and homogeneous perovskite films than those on PTAA and PVCz-FMeNPh. As a result,the dopant-free PVCz-DFMeNPh based inverted quasi-2D PSCs deliver power conversion efficiency(PCE) up to 18.44% as well as negligible hysteresis and favorable long-term stability, which represents as excellent performance reported to date for inverted quasi-2D PSCs. The results demonstrate the great potentials of constructing non-conjugated side-chain polymer HTMs based on phenylfluorenamine-func tionalized PVK for the development of high efficient and stable inverted 3D or quasi-2D PSCs. | Zhengwu Pan Han Gao Yingying Yang Qin Zou Darui Peng Pinghui Yang Jiangli Cai Jin Qian Jiewei Li Chengrong Yin Nana Wang Renzhi Li Jianpu Wang Wei Huang | 2022 | Journal of Energy Chemistry2022，31，6： | 1 |
| 12 | Lipopolysaccharide-Induced Proliferation of the Vasa Vasorum in a Rabbit Model of Atherosclerosis as Evaluated by Contrast-Enhanced Ultrasound Imaging and Histology显示文摘 | Jinwei Tian Sining Hu Xue Han Nana Dong Huai Yu Yanli Sun Bo Yu | 2012 | Inflammation2012，，4： | 1 |
| 13 | Construction of a high-density SSR marker-based linkage map of zoysiagrass (Zoysia japonica Steud.)显示文摘 | Manli Li Nana Yuyama Mariko Hirata Jianguo Han Yunwen Wang Hongwei Cai | 2009 | Euphytica2009，，3： | 1 |
| 14 | Characterization of a recombinant coronavirus infectious bronchitis virus with distinct S1 subunits of spike and nucleocapsid genes and a 3′ untranslated region显示文摘 | Xiaoli Liu Huijie Ma Qianqian Xu Nana Sun Zongxi Han Chuyang Sun Hongbo Guo Yuhao Shao Xiangang Kong Shengwang Liu | 2012 | Veterinary Microbiology2012，，： | 1 |
| 15 | Inflammation and Alzheimer's disease显示文摘 | Lee YJ Han SB Nana SY | 2010 | Arch Pharm Res2010，33，10： | 1 |
| 16 | Characterization of a recombinant coronavirus infectious bronchitis virus with distinct S1 subunits of spike and nucleocapsid genes and a 3′ untranslated region显示文摘 | Xiaoli Liu Huijie Ma Qianqian Xu Nana Sun Zongxi Han Chuyang Sun Hongbo Guo Yuhao Shao Xiangang Kong Shengwang Liu | 2012 | Veterinary Microbiology2012，，： | 1 |
| 17 | Effects of Dispersive Agent and Alumina Micropowder on Workability of Al_2O_3-MgO Castables for Steel Ladles显示文摘This work aims at enhancing the workability of Al2 O3-Mg O castables. Al2 O3-Mg O castables were prepared using tabular alumina particles( 5-3,3-1,≤1 mm),tabular alumina fines( ≤0. 088 mm),fused magnesia( ≤1 mm),reactive alumina micropowder( PFR40,PBR,and CL) and calcined alumina micropowder( AC34 B5 and CT) as the main starting materials,calcium aluminate cement( Secar71) as the binder,and polycarboxylic acid water reducer WS,FS,and AD as the dispersive agent,respectively. Effects of three dispersive agents addition( 0. 4 mass% WS,0. 2 mass% FS and 1 mass% AD),two kinds of reactive alumina micropowder addition( PFR40 and PBR),composite alumina micropowder addition( PFR40-AC34 B5 and CL-CT,the mass ratio from 9/0 to 3/6)on the flow value,apparent porosity,bulk density,cold crushing strength and cold modulus of rupture of Al2 O3-MgO castables were investigated. The results show that:( 1) with PBR or PFR40,the castables with0. 4 mass% WS own better performance than those with0. 2 mass% FS or 1 mass% AD;( 2) compared with the castables with CL-CT composite powder, the castables with PFR40-AC34 B5 composite powder have slightly higher flow value; with the decreasing ratio of PFR40 and AC34 B5,or the decreasing ratio of CL andCT,the castables have declined flow value and the dried castable specimens have decreased density but the mildly changed strength; in consideration of the high price of reactive alumina,a proper compositing ratio shall be selected. | WANG Qingheng LI Yuanbing WEI Hao XU Nana LI Shujing LUO Han XIANG Ruofei | 2018 | China's Refractories2018，27，3： | 0 |
| 18 | Optimal Gestational Weight Gain for Women with Gestational Diabetes Mellitus—China,2011–2021显示文摘Summary What is already known about this topic?Joint effects of gestational weight gain(GWG)and hyperglycemia on adverse pregnancy outcomes suggest that lower optimal GWG is optimal for women with gestational diabetes mellitus(GDM).However,there is still a lack of guidelines.What is added by this report?Optimal weekly GWG range after diagnosis of GDM for underweight,normal-weight,overweight,and obese women was 0.37–0.56 kg/week,0.26–0.48 kg/week,0.19–0.32 kg/week,and 0.12–0.23 kg/week,respectively.What are the implications for public health practice?The findings may be used to inform prenatal counseling regarding optimal gestational weight gain for women with gestational diabetes mellitus,and suggest the need for weight gain management. | Jinlang Lyu Yin Sun Yuelong Ji Nana Liu Suhan Zhang Hang Lin Yaxin Wang Xuanjin Yang Shuai Ma Na Han Yang Mi Dan Zheng Zhifen Yang Hongping Zhang Yan Jiang Liangkun Ma Haijun Wang | 2023 | China CDC weekly2023，5，9： | 0 |
| 19 | Propagation characteristics of low-frequency axisymmetric waves in fluid-filled pipes embedded in the viscoelastic medium显示文摘The propagation characteristics of the low-frequency axisymmetric waves in buried fluid-filled pipes are investigated theoretically,based on the Kennard thin-walled shell equations,the Helmholtz equation,and the Kelvin-Voigt linear viscoelastic model.Analytic expressions of the phase velocity are derived for both the fluid-dominated wave and the shell-compressed wave under lubricated contact,via considering the surrounding soil as a viscoelastic medium.The dispersion and attenuation curves of the two wave types are obtained and verified numerically.The ratio of the radial pipe wall displacements is analyzed,with particular emphasis on the effects of the thickness-to-radius ratio and the quality factor on the dispersion and attenuation characteristics of the fluid-dominated wave.The results show that the viscoelastic property has slight effects on the phase velocities of the two wave types,but it influences the attenuation severely.The fluid-dominated wave influences the radial pipe wall displacement significantly and is the primary carrier of leakage noise energy;its phase velocity increases as a function of the thickness-to-radius ratio while the attenuation decreases.It also shows that the dispersion and attenuation of the fluid-dominated wave decrease as a function of the quality factor.The work will provide insights and guidance for the leakage detection of buried fluid-filled pipes. | QIAN Jiawen HAN Qingbang SU Nana BAI Le QIAN Xintong | 2022 | Chinese Journal of Acoustics2022，41，3： | 0 |
| 20 | High-temperature ferromagnetic metallic phase in LaMnO_(3)/Sr_(3)Al_(2)O_(6)heterostructure显示文摘To achieve a flexible single-crystal multifunctional membrane,the freestanding process of a rigid epitaxial transition metal oxide thin film via a buffered water-dissolution sacrificial layer has attracted reasonable attentions.Owing to the difference in chemical potential,specific element affinity,and lattice constant between the target membrane and the sacrificial layer,the freestanding process may cause an indelible change of physics property once the target thin film is sensitive to the above factors.Here,the heterostructures composed of the generally adopted sacrificial layer Sr_(3)Al_(2)O_(6)(SAO)and LaMnO_(3)(LMO)have been systematically investigated.The electrical and magnetic properties of LMO show extreme sensitivity to the thickness of SAO(tSAO).Then we have also found that LMO/SAO heterostructures can exhibit the coexistence of two ferromagnetic phases,the significantly enhanced Curie temperature~342 K,and the large magnetoresistance-23.3%at 300 K,which is similar to the optimal-doped manganite such as La_(2/3)Sr_(1/3)MnO_(3).X-ray diffraction results show that continuously tunable strain from out-of-plane tension to relaxation and then to compression can be generated by adjusting tSAO.This strain can stabilize the migrated oxygen from LMO to SAO,which is induced by the large oxygen affinity difference between Bsite Mn and Al.It is believed that these unexpected electrical/magnetic phenomena are originated from the combined effects of interfacial element diffusion and strain.Our study provides a strategy for designing new magnetic phases,and a reference for the fundamental understanding of strongly correlated transition metal oxide systems in the freestanding process. | Di Wang Bin He Jinrui Guo Qixiang Wang Chaoqun Shi Yue Han Hong Fang Jie Wang Nana Zhang Peng Zhang Yanan Chen Changwen Zhang Weiming Lü Shishen Yan | 2022 | Journal of Materials Science & Technology2022，，24： | 0 |
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