|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Control of Grain Size and Weight by the OsMKKK10-OsM KK4-OsMAPK6 Signaling Pathway in Rice显示文摘谷物尺寸是在庄稼决定谷物产量的关键农学的特点之一。然而,在庄稼位于谷物尺寸控制下面的机制留下逃犯。这里,我们证明断然表明小径的 OsMKKK10-OsMKK4-OsMAPK6 在米饭调整谷物尺寸和重量。在米饭,当组成地活跃的 OsMKKK10 (CA-OsMKKK10 ) 的 overexpression 导致大、重的谷物,长圆锥花序,和高植物时, OsMKKK10 功能的损失导致小、轻的谷物,短圆锥花序,和半矮子植物。OsMKKK10 交往与并且 phosphorylates OsMKK4。我们识别了 OsMKK4 gain-of-function 异种(large11-1D )? 那生产大、重的谷物。OsMKK4 large11-1D 等位基因编码的 A227T 比 OsMKK4 举办更强壮的 kinase 活动。植物 overexpressing OsMKK4 (OsMKK4-DD ) 的一种组成地活跃的形式也生产大谷物。进一步生物化学、基因的分析表明 OsMKKK10, OsMKK4,和 OsMAPK6 在一条普通小径工作控制谷物尺寸。一起拿,我们的学习在米饭为谷物尺寸和重量的 OsMKKK10-OsMKK4-OsMAPK6 调停串联的控制建立一个重要基因、分子的框架。 | Ran Xu Penggen Duan Haiyue Yu Zhengkui Zhou Baolan Zhang Ruci Wang Jing Li Guozheng Zhang Shangshang Zhuang Jia Lyu Na Li Tuanyao Chai Zhixi Tian Shanguo Yao Yunhai Li | 2018 | Molecular Plant2018，11，6： | 33 |
| 2 | Protective effects of Yindanxinnaotong capsule in a rat model of myocardial ischemia/reperfusion injury显示文摘OBJECTIVE: To investigate the effects of Yindanxinnaotong capsule(YDXNTC) and main components compatibility and ratios on myocardium against ischemia/reperfusion injury and the effect's underlying mechanism.METHODS: Myocardial ischemia/reperfusion injury(MIRI) was induced by ischemia for 30 min and reperfusion for 30 min. Electrocardiogram data and coronary flow were recorded, and superoxide dismutase(SOD), malondialdehyde(MDA), lactate dehydrogenase, creatine kinase-MB, cardiac troponin T and I(cT nT, cT n I) and interleukin-1β, interleukin-8,interleukin-18(IL-1β, IL-8, IL-18) in myocardium were measured. Hypoxia/reoxygenation and hydrogen peroxide(H2O2) injury were induced by hypoxia for 3 h/reoxygenation for 2 h, and 100 μM H2O2 for 1 h, respectively, in vitro rat myocardial cells(H9c2). Cell viability, SOD, MDA, cT nT and inflamma-tory factors(IL-1β, IL-8 and IL-18) were determined,and Toll-like receptor 4(TLR-4) expression was measured by western blotting.RESULTS: In the isolated heart experiment, elevated heart function, coronary flow and SOD levels,and decreased MDA levels and inflammatory factors were noted in the YDXNTC, main components and main components compatibility groups. Ventricular tachycardia/ventricular fibrillation occurrence decreased in the ginkgo biloba extract(GBE),and GBE and salvia miltiorrhiza ethanol extract compatibility(SM-E, GSEC) groups. Lactic dehydrogenase levels decreased in the YDXNTC and aqueous extract of salvia miltiorrhiza(SM-H) groups. Creatine kinase-MB decreased with GBE, SM-E, SM-H and GSEC treatment, and cT n I and cT nT levels decreased with GSEC. In the in vitro cell study,YDXNTC and main components ratios improved cell viability and SOD levels, and suppressed MDA,cT nT and inflammatory factors. TLR-4 expression was down-regulated.CONCLUSION: YDXNTC and main components compatibility showed protective effects on MIRI in this rat model and in vitro study. Regulating the Toll-like receptor signaling pathway may affect the mechanism. | Wandan Wang Lan Wang Hongjun Yang Jianlu Wang Xiaojie Yin Haiyu Xu Long Cheng Rixin Liang | 2014 | Journal of Traditional Chinese Medicine2014，34，6： | 22 |
| 3 | Phosphorus recovery from biogas fermentation liquid by Ca-Mg loaded biochar显示文摘Shortage in phosphorus(P) resources and P wastewater pollution is considered as a serious problem worldwide. The application of modified biochar for P recovery from wastewater and reuse of recovered P as agricultural fertilizer is a preferred process. This work aims to develop a calcium and magnesium loaded biochar(Ca–Mg/biochar) application for P recovery from biogas fermentation liquid. The physico-chemical characterization, adsorption efficiency, adsorption selectivity, and postsorption availability of Ca-Mg/biochar were investigated. The synthesized Ca–Mg/biochar was rich in organic functional groups and in Ca O and Mg O nanoparticles. With the increase in synthesis temperature, the yield decreased, C content increased, H content decreased, N content remained the same basically, and BET surface area increased. The P adsorption of Ca–Mg/biochar could be accelerated by nano-Ca O and nano-Mg O particles and reached equilibrium after 360 min.The process was endothermic, spontaneous, and showed an increase in the disorder of the solid–liquid interface. Moreover, it could be fitted by the Freundlich model. The maximum P adsorption amounts were 294.22, 315.33, and 326.63 mg/g. The P adsorption selectivity of Ca–Mg/biochar could not be significantly influenced by the typical p H level of biogas fermentation liquid. The nano-Ca O and nano-Mg O particles of Ca–Mg/biochar could reduce the negative interaction effects of coexisting ions. The P releasing amounts of postsorption Ca–Mg/biochar were in the order of Ca–Mg/B600 > Ca–Mg/B450 > Ca–Mg/B300. Results revealed that postsorption Ca–Mg/biochar can continually release P and is more suitable for an acid environment. | Ci Fang Tao Zhang Ping Li Rongfeng Jiang Shubiao Wu Haiyu Nie Yingcai Wang | 2015 | Journal of Environmental Sciences2015，27，3： | 21 |
| 4 | Inflammatory response and neuronal necrosis in rats with cerebral ischemia显示文摘In the middle cerebral artery occlusion model of ischemic injury, inflammation primarily occurs in the infarct and peripheral zones. In the ischemic zone, neurons undergo necrosis and apoptosis, and a large number of reactive microglia are present. In the present study, we investigated the pathological changes in a rat model of middle cerebral artery occlusion. Neuronal necrosis appeared 12 hours after middle cerebral artery occlusion, and the peak of neuronal apoptosis appeared 4 to 6 days after middle cerebral artery occlusion. Inflammatory cytokines and microglia play a role in damage and repair after middle cerebral artery occlusion. Serum intercellular cell adhesion molecule-1 levels were positively correlated with the permeability of the blood-brain barrier. These findings indicate that intercellular cell adhesion molecule-1 may be involved in blood-brain barrier injury, microglial activation, and neuronal apoptosis. Inhibiting blood-brain barrier leakage may alleviate neuronal injury following ischemia. | Lingfeng Wu Kunnan Zhang Guozhu Hu Haiyu Yang Chen Xie Xiaomu Wu | 2014 | Neural Regeneration Research2014，9，19： | 19 |
| 5 | A comprehensive review of integrative pharmacology-based investigation:A paradigm shift in traditional Chinese medicine显示文摘Over the past decade,traditional Chinese medicine(TCM) has widely embraced systems biology and its various data integration approaches to promote its modernization.Thus,integrative pharmacology-based traditional Chinese medicine(TCMIP) was proposed as a paradigm shift in TCM.This review focuses on the presentation of this novel concept and the main research contents,methodologies and applications of TCMIP.First,TCMIP is an interdisciplinary science that can establish qualitative and quantitative pharmacokinetics-pharmacodynamics(PK-PD) correlations through the integration of knowledge from multiple disciplines and techniques and from different PK-PD processes in vivo.Then,the main research contents of TCMIP are introduced as follows:chemical and ADME/PK profiles of TCM formulas;confirming the three forms of active substances and the three action modes;establishing the qualitative PK-PD correlation;and building the quantitative PK-PD correlations,etc.After that,we summarize the existing data resources,computational models and experimental methods of TCMIP and highlight the urgent establishment of mathematical modeling and experimental methods.Finally,we further discuss the applications of TCMIP for the improvement of TCM quality control,clarification of the molecular mechanisms underlying the actions of TCMs and discovery of potential new drugs,especially TCM-related combination drug disco very. | Haiyu Xu Yanqiong Zhang Ping Wang Junhong Zhang Hong Chen Luoqi Zhang Xia Du Chunhui Zhao Dan Wu Feng Liu Hongjun Yang Changxiao Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，6： | 18 |
| 6 | Methylmercury and sulfate-reducing bacteria in mangrove sediments from Jiulong River Estuary,China显示文摘Estuaries are important sites for mercury (Hg) methylation,with sulfate-reducing bacteria (SRB) thought to be the main Hg methylators.Distributions of total mercury (THg) and methylmercury (MeHg) in mangrove sediment and sediment core from Jiulong River Estuary Provincial Mangrove Reserve,China were determined and the possible mechanisms of Hg methylation and their controlling factors in mangrove sediments were investigated.Microbiological and geochemical parameters were also determined.Results showed that SRB constitute a small fraction of total bacteria (TB) in both surface sediments and the profile of sediments.The content of THg,MeHg,TB,and SRB were (350±150)ng/g,(0.47±0.11)ng/g,(1.4×10 11±4.1×109)cfu/g dry weight (dw),and (5.0×106±2.7×106)cfu/g dw in surficial sediments,respectively,and (240±24)ng/g,(0.30±0.15)ng/g,(1.9×1011± 4.2×1010)cfu/g dw,and (1.3×106± 2.0×106) cfu/g dw in sediment core,respectively.Results showed that THg,MeHg,TB,MeHg/THg,salinity and total sulfur (TS) increased with depth,but total organic matter (TOM),SRB,and pH decreased with depth.Concentrations of MeHg in sediments showed significant positive correlation with THg,salinity,TS,and MeHg/THg,and significant negative correlation with SRB,TOM,and pH.It was concluded that other microbes,rather than SRB,may also act as main Hg methylators in mangrove sediments. | Hao Wu Zhenhua Ding Yang Liu Jinling Liu Haiyu Yan Jiayong Pan Liuqiang Li Huina Lin Guanghui Lin Haoliang Lu | 2011 | Journal of Environmental Sciences2011，23，1： | 17 |
| 7 | Genesis study of high abundant 17α(H)-diahopanes in Lower Cretaceous lacustrine source rocks of the Lishu Fault Depression, Songliao Basin, Northeast China显示文摘Relatively abundant 17α(H)-diahopanes have been detected in the lower cretaceous lacustrine source rocks from the Lishu Fault Depression in the Songliao Basin Northeast China. Rich long chain tricyclic terpanes(carbon number up to C35) and gammacerane have been observed in those source rocks with relatively abundant 17α(H)-diahopanes, which is rarely seen in previous reports. In this paper, the formation of 17α(H)-diahopanes has been discussed from three aspects including maturity, oxidation-reduction nature of depositional environment and parent material composition by the GC/MS analyses. The results reveal that maturity and oxidation-reduction nature of depositional environment have little effect on the formation of 17α(H)-diahopanes in the investigated area. However, the positive correlation between long-chain tricyclic terpanes and 17α(H)-diahopanes argues strongly for a common origin, and the origin is related to the algaes in saline water environment. The algaes in saline water environment may be a kind of origin of 17α(H)-diahopanes. | LIU Haiyu ZHANG Min LI Xing | 2014 | Chinese Journal Of Geochemistry2014，33，2： | 9 |
| 8 | Isolation of Tyl-copia-like Retrotransposon Sequences from the Apple Genome by Chromosome Walking Based on Modified SiteFinding-polymerase Chain Reaction显示文摘长终端重复(LTR ) retrotransposons 是为学习基因生物多样性,染色体进化,基因变化,克隆的基因和基因表达的强大的工具。缺乏 ofretrotransposon 顺序信息限制在在场的更高的 plants.Inthe 的研究学习的这些的发展, Ty1-copia-like retrotransposons 的 31 逆[转]录酶( RT )基因被放大编码区域使用的 RT 从苹果染色体识别 degenerateprimers.Nineteen RT 基因以碎片尺寸显示出极端异质,基础对作文和开的读框架完全。从一 266 bp 发源克隆 RT 基因, 1966 bpTy1-copia-like retrotransposon (命名 Tcrm1 )包括 RT-ribonuclease H-LTR 领域序列,被染色体在基因结构和 Tcrml 是包括在揭示的 applegenome.Dot 污点分析的一个 LTR 领域的第一 Ty1-copia-like retrotransposon 的顺序相同 hows 基于在 Tcrml 和另外的 LTR retrotransposons 之间的修改SiteFinding聚合酶链 reaction.Thecomparison 走完成在苹果的那个 Tcrm1 拷贝数字每 haploid 是近似 1x10 ~ 3copies 染色体。 | Guiling ZHAO Zhihong ZHANG Haiyue SUN He LI Hongyan DAI | 2007 | Acta Biochimica et Biophysica Sinica2007，39，9： | 8 |
| 9 | Research of Damping System Characteristics for HVDC Converter Valves显示文摘直流换流阀阻尼系统由饱和电抗器铁心电阻和晶闸管级阻尼电阻2部分组成。该文提出了饱和电抗器动态电感和铁心电阻分析计算方法,建立了铁心电阻与磁通密度的函数关系及饱和电抗器等值电路模型。通过对高频电压源激励下端口伏安特性理论计算结果与试验测试结果对比,验证了模型的正确性。提出了阻尼系统抑制振荡电流性能分析方法,给出了晶闸管第1个电流波谷值处于局部极限值的阻尼系统配置方案;分析了阻尼系统冲击电压下辅助限制过电压性能;提出了阻尼系统损耗计算方法,研究了换流阀不同运行状态下的损耗性能。 | LIU Jie ZHANG Jing CAO Junzheng YU Haiyu WEI Xiaoguang XI Hexun | 2012 | 中国电机工程学报2012，32，30： | 6 |
| 10 | Total mercury in wild fish in Guizhou reservoirs, China显示文摘The health hazard of mercury (Hg) compounds is internationally recognized, and the main pathways for methylmercury (MeHg) intake in humans are through consumption of food, especially fish. Given the large releases of Hg to the environment in China, combined with the fast development of hydropower, this issue deserves attention. Provided similar mobilization pathways of Hg in China as seen in reservoirs in North America and Europe one should expect increased Hg contamination in relation to future hydropower reservoir construction in this country. This study presents total Hg (THg) concentrations in wild fish from six Guizhou reservoirs, China. The THg concentrations in fish were generally low despite high background levels in the bedrock and depositions from local point sources. The over all mean ± SD concentration of THg was (0.066 ± 0.078) μg/g (n = 235). After adjusting for among-reservoir variation in THg, there were significant differences in THg among functional groups of the fish, assumed to re?ect trophic levels. Predicted THg- concentration ratios, retrieved from a mixed linear model, between the functional groups were 9:4:4:1 for carnivorous, omnivorous, planktivorous and herbivorous fish. This result indicated that MeHg accumulation may prevail even under circumstances with short food chains as in this Chinese water system. No fish exceeded recommended maximum THg limit for human consumption set by World Health Organization and the Standardization Administration of China (0.5 μg/g fish wet weight (ww)). Only six fish (2.5%) exceeded the maximum THg limit set by US Environmental Protection Agency (0.3 μg/g fish ww). | Haiyu Yan Atle Rustadbakken Heng Yao Thorjorn Larssen Xinbin Feng Ting Liu Lihai Shang Thrond O. Haugen | 2010 | Journal of Environmental Sciences2010，22，8： | 6 |
| 11 | 猪源乳酸杆菌对鼠伤寒沙门氏菌DT104在猪肠道上皮细胞IPEC-J2上粘附的影响显示文摘采用猪肠道上皮细胞株IPEC-J2体外培养模型,考察9株猪源乳酸杆菌对IPEC-J2细胞的粘附特性,以及对鼠伤寒沙门氏菌DT104粘附的竞争、排斥、置换和抗侵袭作用。结果显示,9株乳酸杆菌均能粘附IPEC-J2细胞,粘附率在0.1%-10%之间,具有菌株特异性和浓度效应。乳酸杆菌和沙门氏菌同时加入细胞培养,能竞争性抑制沙门氏菌的粘附,并具有浓度效应,高浓度(109CFU/mL)添加K30、K67和K16时,抑制率可达80%以上。乳酸杆菌预处理细胞后再加入沙门氏菌,高浓度乳酸杆菌可降低沙门氏菌粘附率40%-70%,而中浓度(108CFU/mL)乳酸杆菌能抑制23%-33%沙门氏菌对细胞的侵入。但是,只有高浓度添加乳酸杆菌能置换已经粘附的沙门氏菌,置换率在12%-84%之间。该结果为临床上筛选乳酸杆菌,有效防治猪沙门氏菌病提供了一条新的途径。 | 倪学勤 Joshua Gong 曾东 HaiYu Weido Si 周小秋 | 2008 | 微生物学通报2008，35，7： | 6 |
| 12 | Clinical value of contrast-enhanced ultrasound in improving diagnostic accuracy rate of transthoracic biopsy of anteriormedial mediastinal lesions显示文摘Objective: To evaluate the clinical value of contrast-enhanced ultrasound(CEUS) in transthoracic biopsy of anterior-medial mediastinal lesions.Methods: A total of 123 patients with anterior or middle mediastinum lesions required ultrasound guided transthoracic biopsy for pathological diagnosis. Among them, 72 patients received CEUS examinations before biopsy. After CEUS, 8 patients were excluded from biopsy and the rest 64 patients underwent biopsy(CEUS group). During the same period, 51 patients received biopsy without CEUS examination(US group). The ultrasonography characteristics, the number of biopsy puncture attempts, diagnostic accuracy rate and the incidence of complications were recorded and compared between the two groups.Results: A large portion of necrosis area or superficial large vessels was found in 8 patients, so the biopsy was cancelled. The internal necrosis was demonstrated in 43.8% of the lesions in CEUS group and in 11.8% of US group(P>0.001). For thymic carcinoma, CEUS increased the detection rate of internal necrosis and pericardial effusion than conventional ultrasound(62.5% vs. 18.8%, P=0.012; 56.3% vs. 12.5%, P=0.023). The average number of punctures in CEUS group and US group was 2.36±0.70 and 2.21±0.51 times, respectively(P>0.05). The diagnostic accuracy rate of biopsy in CEUS group(96.9%, 62/64) was significantly higher than that in US group(84.3%, 43/51)(P=0.022). In US group, 2 patients suffered from mediastinal bleeding(3.9%), while no major complications occurred in CEUS group.Conclusions: CEUS examination provided important information before transthoracic mediastinum biopsy and improved diagnostic accuracy rate in biopsy of anterior and middle mediastinum lesions than conventional ultrasound. | Jingjing Fu Wei Yang Song Wang Jing Bai Hao Wu Haiyue Wang Kun Yan Minhua Chen | 2016 | Chinese Journal of Cancer Research2016，28，6： | 5 |
| 13 | Nitrogen and phosphorus balance analysis of cultivated land in Jiangsu plain,China显示文摘Jiangsu plain is located along the downstream of the Yangtze River, the north part of which is also the coast area of the Yellow Sea. The specific location makes the local environmental issues regionally important. This paper studied arable land area, plantation structure, livestock sector data, which shows that livestock sector contributes a big amount of nitrogen and phosphorus, in terms of the demand from the agriculture use in Jiangsu plain. But actually, there is still much mineral fertiliser used in agriculture, which causes the N and P produced from livestock sector being an important source of pollution to the environment. The paper suggests to tighten up manure management, in order to lead to a big reduction in the pollution to both soil and surface water. | ZOU Xinqing Pierre Gerber LI Haiyu LIU Qingsong WANG Qian SHEN Jingfen SHI Binwen | 2001 | Chinese Science Bulletin2001，46，S1： | 5 |
| 14 | Distribution and speciation of mercury in the Hongfeng Reservoir,Guizhou Province, China显示文摘The water, pore water, sediment, and fish samples were collected from the Hongfeng Reservoir in No- vember 2003 and February 2004 in accordance with trace metal protocols. The average concentrations of total mer- cury (THg), dissolved mercury (DHg), reactive mercury, dissolved gaseous mercury, total methylmercury, and dis- solved methylmercury in the water columns were 8.00, 5.70, 0.63, 0.05, 0.16, and 0.07 ng/L, respectively. THg and DHg in the water columns, THg in pore water and THg in lake sediments of the Hongfeng Reservoir showed the level of mercury in the Hongfeng Reservoir was higher than in other natural waters in the world due to the loading of a lot of waste water with relatively high concentrations of mercury, whereas methylmercury concentrations in fish (wet weight) varied from 1.73–51.00 ng/g, much lower than in most remote lakes and reservoirs reported in northern Europe and North America. Methylmercury distributions in pore water and sediments showed methylation oc- curred mainly in the upper several centimeters of sediment cores in the Hongfeng Reservoir. The concentrations of dissolved organic carbon, total suspended particles, total Hg, and methylmercury were higher at Houwu than those at Daba in November 2003. It is suggested that other pollutants such as N and P from fishing farm and other waste water at Houwu,which resulted in deterioration of water quality, affected the concentrations and distributions of mercury species in the reservoir. | HE Tianrong FENG Xinbin GUO Yanna QIU Guangle YAN Haiyu MENG Bo | 2008 | Chinese Journal Of Geochemistry2008，27，1： | 5 |
| 15 | The correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma patients: a single center case series显示文摘Objective:To investigate the correlation and overlaps between PD-L1 expression and classical genomic aberrations in Chinese lung adenocarcinoma(LADC)patients.Methods:We reviewed 428 consecutive,surgically resected cases of LADC from October 2015 to December 2016 from our center.PD-L1 expression was evaluated based on tumor proportion score(TPS).Correlation and co-occurrence of PD-L1 expression level with those of classical driver genes,such as EGFR,ALK,ROS-1,and KRAS and with clinical variables and disease-free survival(DFS)were analyzed.Results:Seventy of the 428 cases(16.4%)showed TPS≥1%,and 21 cases(4.9%)showed TPS≥50%.PD-L1 positive expression was significantly associated with male gender,smoking,advanced TNM stage,and solid histologic subtype.Both TPS≥1% and ≥50%were correlated with the absence of an EGFR mutation(P<0.001)and the presence of ALK rearrangement(P=0.024).KRAS mutation was associated with TPS≥50%(P=0.035).PD-L1 positivity commonly overlapped with the alterations of classical driver oncogenes(58.5%with TPS≥1% and 42.9% with TPS≥50%).Approximately three-quarters of PD-L1 positive cases co-occurred with classical therapeutic-gene aberrations in cases with stage III/IV cancer or cancer progression.LADC could be divided into four subgroups based on the expression profile of current routine biomarkers for potential therapeutic strategies.Conclusions:PD-L1 expression is not only closely correlated with classic gene alterations but also commonly overlaps with the aberrations of classical driver oncogenes in Chinese LADC patients.These findings provide a useful overview of clinical strategies that rely on the profile of routinely used molecular biomarkers. | Jianghua Wu Wei Sun Haiyue Wang Xiaozheng Huang Xinyu Wang Weiyang Jiang Ling Jia Ping Wang Qin Feng Dongmei Lin | 2019 | Cancer Biology & Medicine2019，16，4： | 5 |
| 16 | Exchange Rate Risk, Political Environment and Chinese Outward FDI in Emerging Economies: A Panel Data Analysis显示文摘 | Chong Li Haiyue Liu Ying Jiang | 2015 | Economics World2015，3，3： | 4 |
| 17 | PEGylation of Double-Walled Carbon Nanotubes for Increasing Their Solubility in Water显示文摘Polyethylene glycol(PEG)functionalized double-walled carbon nanotubes(DWNTs)have been synthesized by a[2+1]cycloaddition reaction and characterized by transmission electron microscopy,atomic force microscopy,Raman spectroscopy,thermal gravimetric analysis,and UV-visible spectroscopy.Functionalization affords a large increase in the aqueous solubility of DWNTs.The saturated concentrations of DWNTs functionalized with diazido-terminated PEG800(with a molecular weight of 800)and azido-terminated PEG750 monomethylether(with a molecular weight of 750)are very similar-0.36 and 0.37 mg/mL(DWNTs equivalent concentration),respectively. | Haiyu Nie Wei Guo Yuan Yuan Zengpei Dou Zujin Shi Zhen Liu Haifang Wang Yuanfang Liu | 2010 | Nano Research2010，3，2： | 4 |
| 18 | Improved breakdown strength and energy density of polyimide composites by interface engineering between BN and BaTiO3 fibers显示文摘Conventionally,interface effects between polymers and fillers are essential for determining the breakdown strength and energy storage density of polymer-based dielectric composites.In this study,we found that interface effects between different fillers have similar behavior.BN and Ba TiO3 fiber composite fillers with three different interface bonding strengths were successfully achieved by controlling composite processes(BT-fiber/BN | Baoquan Wan Haiyu Li Yunhui Xiao Zhongbin Pan Qiwei Zhang | 2021 | Journal of Materials Science & Technology2021，，15： | 4 |
| 19 | Postoperation of preauricular fistula cellulitis caused by methicillin-resistant staphylococcus aureus infection显示文摘A one-year-old baby girl with one-month history of recurrent pus fluid exuding from her left preauricular sinus orifice, who failed multiple courses of surgical drainage of the abscess and persistent debridement for the wound, presented with MRSA infection. The patient was treated with linezolid for three days. Her pain and paresthesia resolved, and C-reactive protein decreased to normal. | Haiyue Tian Cuiping Zhong | 2018 | Journal of Otology2018，13，3： | 3 |
| 20 | ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine显示文摘Existing traditional Chinese medicine(TCM)-related databases are still insufficient in data standardization,integrity and precision,and need to be updated urgently.Herein,an Encyclopedia of Traditional Chinese Medicine version 2.0(ETCM v2.0,http://www.tcmip.cn/ETCM2/front/#/)was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient Chinese medical books,9872 Chinese patent drugs,2079 Chinese medicinal materials and 38,298 ingredients.To facilitate the mechanistic research and new drug discovery,we improved the target identification method based on a two-dimensional ligand similarity search module,which provides the confirmed and/or potential targets of each ingredient,as well as their binding activities.Importantly,five TCM formulas/Chinese patent drugs/herbs/ingredients with the highest Jaccard similarity scores to the submitted drugs are offered in ETCM v2.0,which may be of significance to identify prescriptions/herbs/ingredients with similar clinical efficacy,to summarize the rules of prescription use,and to find alternative drugs for endangered Chinese medicinal materials.Moreover,ETCM v2.0 provides an enhanced Java Script-based network visualization tool for creating,modifying and exploring multi-scale biological networks.ETCM v2.0 may be a major data warehouse for the quality marker identification of TCMs,the TCM-derived drug discovery and repurposing,and the pharmacological mechanism investigation of TCMs against various human diseases. | Yanqiong Zhang Xin Li Yulong Shi Tong Chen Zhijian Xu Ping Wang Meng Yu Wenjia Chen Bing Li Zhiwei Jing Hong Jiang Lu Fu Wenjing Gao Yanhua Jiang Xia Du Zipeng Gong Weiliang Zhu Hongjun Yang Haiyu Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员