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| 1 | Exome sequencing confirms molecular diagnoses in 38 Chinese families with hereditary spherocytosis显示文摘Hereditary spherocytosis(HS), the most common cause of congenital hemolytic anemia, is caused by deficiency of the erythrocyte membrane proteins. Five causative genes(ANK1, SPTB, SPTA1, SLC4 A1, and EPB42) have been identified. To date,molecular genetic studies have been performed in different populations, including the American, European, Brazilian, Japanese and Korean populations, whereas only a few studies have been described in the Chinese population. Here, by reanalysis of the exome data, we revealed causative mutations and established a definitive diagnosis of HS in all 38 Chinese families. We found 34 novel mutations and four reported mutations in three known HS-causing genes—17 in ANK1, 17 in SPTB and four in SLC4 A1,suggesting that ANK1 and SPTB are the major genes in Chinese patients with HS. All of the ANK1 or SPTB mutations, scattered throughout the entire genes, are non-recurrent; and most of them are null mutations, which might cause HS via a haploinsufficiency mechanism. De novo mutations in ANK1 or SPTB often occur with an unexpected high frequency(87.5% and64.2%, respectively). Our study updates our knowledge about the genetic profile of HS in Chinese and shows that family-based,especially parent-offspring trio, sequencing analysis can help to increase the diagnostic power and improve diagnostic efficiency. | Rongrong Wang Shuanghao Yang Ming Xu Jia Huang Hongyan Liu Weiyue Gu Xue Zhang | 2018 | Science China(Life Sciences)2018，61，8： | 22 |
| 2 | Baicalin extracted from Huangqin(Radix Scutellariae Baicalensis) induces apoptosis in gastric cancer cells by regulating B cell lymphoma(Bcl-2)/Bcl-2-associated X protein and activating caspase-3 and caspase-9显示文摘OBJECTIVE:To evaluate the effects of baicalin in human gastric cancer cells, including apoptosis-inducing effects, and to investigate its underlying mechanisms of action.METHODS:Cell proliferation and apoptosis assays were performed to investigate the anti-proliferation effects of baicalin in human gastric cancer BGC-823 and MGC-803 cells.Real time-quantitative polymerase chain reaction and Western blotting analysis were performed to elucidate the molecular mechanisms underlying the anti-tumor properties of baicalin.RESULTS:In BGC-823 and MGC-803 gastric cancer cells treated with 80, 120, and 160 μmol/L baicalin for 48 h, a 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide assay showed that baicalin significantly inhibited cell proliferation in a dose-dependent manner, while flow cytometric analysis demonstrated that baicalin could induce apoptosis, also in a dose-dependent manner.Moreover, baicalin up-regulated the expression of caspase-3, caspase-9, and B cell lymphoma(Bcl-2)-associated X protein and down-regulated the expression of Bcl-2 at both the m RNA and protein level.CONCLUSION:Baicalin has potential as a therapeutic agent for gastric cancer by inducing apoptosis in cancer cells. | Wang Hongwei Li Hailong Chen Fengqin Luo Jun Gu Jing Wang Huping Wu Hongyan Xu Yan | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 13 |
| 3 | Seismogenesis and occurrence of earthquakes as observed by temporally continuous gravity variations in China显示文摘In the last decade and a half, a number of earthquakes of magnitude 4-5 have occurred in the Beijing_Tianjin_Tangshan_Zhangjiakou (BTTZ) region. On the basis of the analysis of the temporally continuous gravity variation data principally from the Baijiatuan (BJTN) semi_permanent gravity base station, a general picture of gravity variation related to the seismogenesis and occurrence of earthquakes has emerged.\;As gravity variation is generally observed on the earth’s surface, the predominant influence is that of the near_surface groundwater. The subsurface fluids are distributed throughout all depths in the crust and respond to the seismogenic processes of earthquakes as well. The influence of the subsurface fluid on gravity variation is, therefore, of equal importance. The fluids, which include the near_surface groundwater and the subsurface fluids distributed throughout all depths in the crust, play a more important role in the gravity variations in terms of the seismogenesis and occurrence of earthquakes than previously realized.\;The abundance of accumulated data shows that the dilatancy instability (IPE) model seems not applicable at least to the seismogenesis and occurrence of earthquakes in the BTTZ region. In order to reflect the physical reality, the earlier proposed combined dilatancy model requires modification. The seismogenic area in the BTTZ region may be modelled as a large pre_stressed volume of a fluid_filled poroelastic medium, including not only the pre_stressed volume surrounding the impending rupture zone but also the volume containing the rupture of the fault zone itself. The pre_stressed volume outside the impending rupture zone is under a state of relatively small change of the pre_existing regional tectonic stress, while the volume containing the impending rupture zone is an induced region of very high local stress concentration, and/or pore over_pressure.\;The calculated gravity variations based on the modified combined dilatancy model (MCDM) with the known physical parameters of the region resemble the observed residual gravity variations. Apparently the residual gravity variations, in addition to responding to the deep_seated seismogenesis and occurrence of earthquakes, predominantly respond to the near_surface groundwater, and the subsurface fluids, which themselves also respond to the seismogenesis and occurrence of earthquakes. On the basis of comparison between the calculated MCDM gravity variations and the observed residual gravity variations, the change of the regional tectonic stress field for the earthquakes of magnitude 4-5 in the BTTZ region could be approximately estimated to be in the neighbourhood of 5%-7%.\;It is apparent that simultaneously monitoring the temporally continuous variations of the near_surface groundwater, subsurface fluids, and gravity coupled with modelling would provide vital information on the history and evolution of the seismogenic processes about 10 months to 1 year prior to the occurrence of an earthquake of magnitude 4-5 and tens of years prior to that of an earthquake of magnitude 7-8 such as the Haicheng earthquake in 1975 and the Tangshan earthquake in 1976 in the BTTZ region. These earthquakes of magnitude 4-5, which so far have occurred in the BTTZ region, may well be the precursory events to a larger earthquake. | Gongxu Gu John T. Kuo Keren Liu Jinhan Zheng Hongyan Lu Duanfa Liu | 1998 | Chinese Science Bulletin1998，43，1： | 10 |
| 4 | Optical observations of LIGO source GW 170817 by the Antarctic Survey Telescopes at Dome A,Antarctica显示文摘The LIGO detection of gravitational waves(GW) from merging black holes in 2015 marked the beginning of a new era in observational astronomy. The detection of an electromagnetic signal from a GW source is the critical next step to explore in detail the physics involved. The Antarctic Survey Telescopes(AST3),located at Dome A, Antarctica, is uniquely situated for rapid response time-domain astronomy with its continuous night-time coverage during the austral winter. We report optical observations of the GW source(GW 170817) in the nearby galaxy NGC 4993 using AST3. The data show a rapidly fading transient at around 1 day after the GW trigger, with the i-band magnitude declining from 17:23 ± 0:13 magnitude to 17:72 ± 0:09 magnitude in ~1:8 h. The brightness and time evolution of the optical transient associated with GW 170817 are broadly consistent with the predictions of models involving merging binary neutron stars. We infer from our data that the merging process ejected about ~10^(-2) solar mass of radioactive material at a speed of up to 30% the speed of light. | lei hu xuefeng wu igor andreoni michael c.b.ashley jeff cooke xiangqun cui fujia du zigao dai bozhong gu yi hu haiping lu xiaoyan li zhengyang li ensi liang liangduan liu bin ma zhaohui shang tianrui sun n.b.suntzeff charling tao syed a.uddin lifan wang xiaofeng wang haikun wen di xiao jin xu ji yang shihai yang xiangyan yuan hongyan zhou hui zhang jilin zhou zonghong zhu | 2017 | Science Bulletin2017，62，21： | 6 |
| 5 | In vitro and in vivo degradation behavior of Mg-2Sr-Ca and Mg-2Sr-Zn alloys显示文摘Magnesium alloys with integration of degradability and good mechanical performance are desired for orthopedic implants.In this paper,Mg-2Sr-Ca and Mg-2Sr-Zn alloys were prepared and the degradation as well as the bone response were investigated.Compared with the binary Mg-2Sr alloys,the addition of Ca and Zn improved the in vitro and in vivo corrosion resistance.Mg-2Sr-Ca and Mg-2Sr-Zn alloys exhibited more uniform corrosion and maintained the configuration of the implants 4 weeks post-implantation.The in vivo corrosion rates were 0.85 mm/yr for Mg-2Sr-Zn and 1.10 mm/yr for Mg-2Sr-Ca in comparison with 1.37 mm/yr for Mg-2Sr.The in vitro cell tests indicated that Mg-2Sr-Ca and Mg-2Sr-Zn alloys exhibited higher MG63 cell viability than Mg-2Sr alloy.Furthermore,these two alloys can promote the mineralization and new bone formation without inducing any significant adverse effects and this sound osteogenic properties suggest its attractive clinical potential. | Kai Chen Xinhui Xie Hongyan Tang Hui Sun Ling Qin Yufeng Zheng Xuenan Gu Yubo Fan | 2020 | Bioactive Materials2020，5，2： | 6 |
| 6 | Synthesis and evaluation of methionine and folate co-decorated chitosan self-assembly polymeric micelles as a potential hydrophobic drug-delivery system显示文摘In this study, an amphiphilic copolymer folate-succinyl-methionine-chitosan-octyl (FSMCO) was successfully synthesized step by step for self-assembling polymeric micelles. The copolymers formed micelle-like nanoparticles by their amphiphilic characteristics and structures were examined by UV-Vis absorption and Fourier transform spectroscopy. The sizes of blank and ICG derivativeloaded micelles measured by dynamic light scattering were about 170 and 140 nm, respectively, which were spherical in shape with an average zeta potential of 10 mV. Further studies on the stability showed that the micellar solutions maintain their sizes at room temperature for 1 month without distinct aggregation or dissociation. ICG derivative was much better photostable after being entrapped by the new carrier. The prepared FSMCO micelles displayed a good drug loading content (11.7%), entrapment efficiency (66.5%) and sustained release rate for the model drug fluorescein. The copolymers demonstrated weeny cytotoxicity toward Bel-7402, L02 and A549 cells when incubated for 2 d. Ligands modified micelles endowed preferable cell targeting capability and beautiful cell inhibition of HCPT-FSMCO on Bel-7402 tumor cells. This kind of polymeric micelles may be a promising nanovehicle in delivering near-infrared dyes for tumors imaging and chemotherapeutic drugs for cancer therapeutics. | CHEN YuQi CAO Jie ZHU HongYan CUI SiSi WANG AQin QIAN ZhiYu GU YueQing | 2013 | Chinese Science Bulletin2013，58，19： | 3 |
| 7 | CFD simulation of pressure fluctuation characteristics in the gas-solid fluidized bed:Comparisons with experiments显示文摘A simple hydrodynamic model based on two-fluid theory,taking into account the effect of discrete particles on both the gas-and solid-phase momentum equations,was used to numerically investigate the pressure fluctuation characteristics in a gas-solid fluidized bed with the aid of CFX 4.4,a commercial CFD software package,by adding user-defined Fortran subroutines.Numerical simulations together with typical experimental measurements show that pressure fluctuations originate above the distributor when a gas pulse is injected into the fluidized bed.The pressure above the bubble gradually increases due to the presence of a rising bubble.When the bubble passes through the bed surface,the pressure near the bed surface gradually decreases to a lower value.Moreover,the pressure signals in the bubbling fluidized beds show obviously periodic characteristics.The major frequency of pressure fluctuations at the same vertical position is affected slightly by the operating gas velocity,and the amplitude of pressure fluctuations is related to both the operating gas velocity and the vertical height.In this study,the influence of the operating gas velocity on the pressure wave propagation velocity can be ignored,and only two peak frequencies in the power spectrum of the pressure fluctuations are observed which are associated with the bubble formation above the distributor and its eruption at the bed surface. | Wang Qingcheng Zhang Kai Gu Hongyan | 2011 | Petroleum Science2011，8，2： | 3 |
| 8 | Waste biomass from production process co-firing with coal in a steam boiler to reduce fossil fuel consumption:A case study显示文摘Waste biomass is always generated during the production process in industries.The ordinary way to get rid of the waste biomass is to send them to landfill or burn it in the open field.The waste may potentially be used for co-firing with coal to save fossil fuel consumption and also reduce net carbon emissions.In this case study,the bio-waste from a Nicotiana Tabacum(NT) pre-treatment plant is used as the biomass to co-fire with coal.The samples of NT wastes were analysed.It was found that the wastes were of the relatively high energy content which were suitable for co-firing with coal.To investigate the potential and benefits for adding NT wastes to a Fluidised Bed Combustion(FBC) boiler in the plant,detailed modelling and simulation are carried out using the European Coal Liquefaction Process Simulation and Evaluation (ECLIPSE) process simulation package.The feedstock blending ratios of NT waste to coal studied in this work are varied from 0%to 30%. The results show that the addition of NT wastes may decrease the emissions of CO2 and SOx without reducing the boiler performance. | Hongyan Gu Kai Zhang Yaodong Wang Ye Huang Neil Hewitt Anthony P Roskilly | 2013 | Journal of Energy Chemistry2013，22，3： | 3 |
| 9 | Retro-enantio isomer of angiopep-2 assists nanoprobes across the blood-brain barrier for targeted magnetic resonance/fluorescence imaging of glioblastoma显示文摘Glioblastoma(GBM),one of the most common primary intracranial malignant tumours,is very difficult to be completely excised by surgery due to its irregular shape.Here,we use an MRI/NIR fluorescence dual-modal imaging nanoprobe that includes superparamagnetic iron oxide nanoparticles(SPIONs)modified with indocyanine(Cy7)molecules and peptides(ANG orDANG)to locate malignant gliomas and guide accurate excision.Both peptides/Cy7-SPIONs probes displayed excellent tumour-homing properties and barrier penetrating abilities in vitro. | Ruoxi Xie Zijun Wu Fanxin Zeng Huawei Cai Dan Wang Lei Gu Hongyan Zhu Su Lui Gang Guo Bin Song Jinxing Li Min Wu Qiyong Gong | 2021 | Signal Transduction and Targeted Therapy2021，6，9： | 3 |
| 10 | Atacamite and Nantokite in Kaerqueka Copper Deposit of Qimantag Area:Evidence for Cenozoic Climate Evolution of the Qaidam Basin显示文摘Using a mineralogy method to reflect climate evolution is a new approach to research Cenozoic environmental progression of the Qaidam Basin. In this paper, we present the chemical composition and crystallographic parameter of atacamite, nantokite, and tenorite in cryptocrystalline aggregates from the Kaerqueka copper deposit of Qimantag metallogenic belt by means of electron microprobe and in-situ X-ray diffraction analyses. Atacamite and nantokite occur in an intimate intergrowth as the secondary precipitation of chalcopyrite and bornite filling in the interstitial space of andradite in the Kaerqueka copper deposit, with an average composition of Cl: 12.38 wt.%, Cu: 63.76 wt.%, O: 21.46 wt.%. X-ray microdiffraction shows that the intergrowth contains nantokite with a cubic unit cell a=5.403(2) ? and atacamite with an orthorhombic unit cell a=6.030(3), b=6.883(2), c=9.114(1) ?. XRD quantitative calculation shows that the nanometric aggregate contains 36.07 wt.% tenorite, 18.41 wt.% atacamite, and 45.52 wt.% nantokite. The presence of nantokite and atacamite requires saline solutions for their formation and hyper-arid climate conditions for their preservation. Combined with the data of salt lakes and the pollen sequence of western China, we suggest that during the uplift of the Tibetan Plateau and the retreat of the Paratethys, saline water was forced to the surface through a basal fracture zone. In the hyper-arid climate of the Qaidam Basin, the recharge of groundwater by direct precipitation is negligible, and groundwater is derived from inflow from the salt lakes. Thus, atacamite is preserved. In addition, spertiniite in the edge and fractures of atacamite and nantokite may represent wetter climate after the formation of atacamite and nantokite. | Liwen Yi Xiangping Gu Anhuai Lu Xiangyu Li Dexian Zhang Zhiling Wang Jianping Liu Shuai Li Zhengxiang Shu Cui Yu Hongyan Zuo Can Shen | 2017 | Journal of Earth Science2017，28，3： | 3 |
| 11 | LHCGR and ALMS1 defects likely cooperate in the development of polycystic ovary syndrome indicated by double-mutant mice显示文摘Polycystic ovary syndrome(PCOS)is a heterogeneous disorder with evidence of polygenetic components,and obesity may be a risk factor for hyperandrogen ism.Previous studies have shown that LHCGR is en riched in the ovary and LHCGR deficiency causes infertility without typical PCOS phenotypes.ALMS1 is implicated in obesity and hyperandrogenism,the common phenotypes among PCOS patients.Through whole-exome sequencing of 22 PCOS families and targeted candidate gene sequencing of additional 65 sporadic PCOS patients,we identified potential causative mutations in LHCGR and ALMS1 in a sibling-pair PCOS family and three sporadic PCOS patients.The expression of LHCGRL638 P in granulosa-like tumor cell line(KGN)cells promoted cyclic adenosine monophosphate production and granulosa cell proliferation,indicating that LHCGRL638 P is an activating mutation.Lhcgr~(L642 P/L642 P)mice showed an irregular estrous cycle,reduced follicles with dynamic folliculogenesis,and increased testosterone(T),estradiol(E2),and dehydroepiandrosterone.Lhcgr~(+/L642 P)AIms1~(+/PB)mice displayed increased T and E2 but decreased late secondary and preovulatory follicles.We showed that activating mutation of LHCGR likely plays important roles in the pathophysiology of PCOS involving abnormal reproductive physiology,whereas ALMS1 deficiency may promote anovulatory infertility via elevated androgens,suggesting that the disturbed LHCGR and ALMS1 cooperatively induce PCOS phenotypes,characterized as anovulation and hyperandrogenemia frequently observed in PCOS patients with obesity. | Li Yu Lina Wang Wufan Tao Wenxiang Zhang Shuanghao Yang Jian Wang Jia Fei Rui Peng Yiming Wu Xiumei Zhen Hong Shao Weiyue Gu Rong Li Bai-Lin Wu Hongyan Wang | 2021 | Journal of Genetics and Genomics2021，48，5： | 3 |
| 12 | Assessments of mortality at oldest-old ages by province in China's 2000 and 2010 censuses显示文摘This study examined the possible underestimation and age-trajectories of mortality at oldest-old ages in China’s 2000 and 2010 censuses.By linking logit-transformed conditional probabilities of dying from 13 countries with the highest data quality in the world,this study found that many Chinese provinces had underestimations of mortality at oldest-old ages when a relatively lenient criterion was applied.When a relatively strict criterion was applied,most provinces had a 30%or more underestimation in the probability of dying.We also investigated age trajectories of death rates after age 80 in these two censuses by applying the Kannisto model.Results showed that the age trajectories were distorted in most provinces after age 95.Overall,eastern-coastal provinces had higher data quality—in terms of low underestimation rates and less distorted age trajectories—whereas western China had provinces with problematic data.Females had greater rates of underestimation yet less distorted age-trajectories than males;and the 2010 census had greater rates of underestimation yet less distorted age-trajectories than the 2000 census.We conclude that appropriate adjustments with simultaneous applications of the Kannisto model are needed for direct estimates of mortality at oldest-old ages in the 2000 and 2010 censuses for China and for its provinces. | Danan Gu Runlong Huang Kirill Andreev Matthew E.Dupre Yaer Zhuang Hongyan Liu | 2016 | International Journal of Population Studies2016，2，2： | 2 |
| 13 | Major and Trace Elements of Magnetite from the Qimantag Metallogenic Belt: Insights into Evolution of Ore–forming Fluids显示文摘Magnetite, as a genetic indicator of ores, has been studied in various deposits in the world. In this paper, we present textural and compositional data of magnetite from the Qimantag metallogenic belt of the Kunlun Orogenic Belt in China, to provide a better understanding of the formation mechanism and genesis of the metallogenic belt and to shed light on analytical protocols for the in situ chemical analysis of magnetite. Magnetite samples from various occurrences, including the ore–related granitoid pluton, mineralised endoskarn and vein–type iron ores hosted in marine carbonate intruded by the pluton, were examined using scanning electron microscopy and analysed for major and trace elements using electron microprobe and laser ablation–inductively coupled plasma–mass spectrometry. The field and microscope observation reveals that early–stage magnetite from the Hutouya and Kendekeke deposits occurs as massive or banded assemblages, whereas late–stage magnetite is disseminated or scattered in the ores. Early–stage magnetite contains high contents of Ti, V, Ga, Al and low in Mg and Mn. In contrast, late–stage magnetite is high in Mg, Mn and low in Ti, V, Ga, Al. Most magnetite grains from the Qimantag metallogenic belt deposits except the Kendekeke deposit plot in the ' Skarn ' field in the Ca+Al+Mn vs Ti+V diagram, far from typical magmatic Fe deposits such as the Damiao and Panzhihua deposits. According to the(Mg O+Mn O)–Ti O2–Al2O3 diagram, magnetite grains from the Kaerqueka and Galingge deposits and the No.7 ore body of the Hutouya deposit show typical characteristics of skarn magnetite, whereas magnetite grains from the Kendekeke deposit and the No.2 ore body of the Hutouya deposit show continuous elemental variation from magmatic type to skarn type. This compositional contrast indicates that chemical composition of magnetite is largely controlled by the compositions of magmatic fluids and host rocks of the ores that have reacted with the fluids. Moreover, a combination of petrography and magnetite geochemistry indicates that the formation of those ore deposits in the Qimantag metallogenic belt involved a magmatic–hydrothermal process. | YI Liwen GU Xiangping LU Anhuai LIU Jianping LEI Hao WANG Zhiling CUI Yu ZUO Hongyan SHEN Can | 2015 | Acta Geologica Sinica(English Edition)2015，89，4： | 2 |
| 14 | Detection of ECTV,MHV and SV in Clean-grade Mice and Rats in East China显示文摘To study the epidemic status of Ectromelia virus( ECTV),Mouse hepatitis virus( MHV) and Sendai virus( SV) in clean-grade experimental mice and rats in East China,30 individuals of ICR and/or C57BL/6 mice and 15 individuals of SD or Wistar rats were purchased from four major experimental animal supply bases in East China. Blood samples were collected by eyeball picking method,and serum was separated. ECTV,MHV and SV serum antibodies in mice were detected using imported commercial ELISA kits. Since rats were not easily infected by MHV and SV,only the ECTV serum antibody was detected in rats. Survey results revealed that clean-grade experimental mice and rats derived from three out of four major experimental animal supply bases were negative in detection,but the positive rates of MHV and SV serum antibody in clean-grade ICR mice in one supply base were 56. 7% and 100. 0%,respectively,while the positive rate of MHV serum antibody in C57BL/6 mice was 100%. Research results showed that most of the commercial experimental mice and rats in major experimental animal supply bases in East China were qualified in detection of above three kinds of diseases,but MHV and SV still existed in individual base,with severe infection status.Thus,active measures must be strengthened to purify mice and rats. Meanwhile,monitoring of mouse and rat diseases must be developed seriously to guarantee the quality of experimental mice and rats,so as to avoid adverse impacts on breeding and use of experimental rats and mice. | Song Hongyan Dong Ronglian Qiu Baofeng Jing Jin Gu Bingquan Shao Yixiang Liu Chun Zhu Shunxing Wu Liucheng | 2017 | Animal Husbandry and Feed Science2017，9，1： | 1 |
| 15 | Polymorphisms of the vascular endothelial growth factor A gene and susceptibility to sporadic brain arteriovenous malformation in a Chinese population显示文摘 | Hongyan Chen Yuxiang Gu Wenting Wu Dan Chen Peiliang Li Weiwei Fan Daru Lu Fan Zhao Nidan Qiao Huijia Qiu Chaowei Fu Ying Mao Yao Zhao | 2010 | Journal of Clinical Neuroscience2010，，4： | 1 |
| 16 | A surface-eroding poly(1,3-trimethylene carbonate)coating for magnesium based cardiovascular stents with stable drug release and improved corrosion resistance显示文摘Magnesium alloys with integration of degradability and good mechanical performance are desired for vascular stent application.Drug-eluting coatings may optimize the corrosion profiles of magnesium substrate and reduce the incidence of restenosis simultaneously.In this paper,poly(trimethylene carbonate)(PTMC)with different molecular weight(50,000 g/mol named as PTMC5 and 350,000 g/mol named as PTMC35)was applied as drug-eluting coatings on magnesium alloys.A conventional antiproliferative drug,paclitaxel(PTX),was incorporated in the PTMC coating.The adhesive strength,corrosion behavior,drug release and biocompatibility were investigated.Compared with the PLGA control group,PTMC coating was uniform and gradually degraded from surface to inside,which could provide long-term protection for the magnesium substrate.PTMC35 coated samples exhibited much slower corrosion rate 0.05μA/cm^(2)in comparison with 0.11μA/cm^(2)and 0.13μA/cm^(2)for PLGA and PTMC5 coated counterparts.In addition,PTMC35 coating showed more stable and sustained drug release ability and effectively inhibited the proliferation of human umbilical vein vascular smooth muscle cells.Hemocompatibility test indicated that few platelets were adhered on PTMC5 and PTMC35 coatings.PTMC35 coating,exhibiting surface erosion behavior,stable drug release and good biocompatibility,could be a good candidate as a drug-eluting coating for magnesium-based stent. | Hongyan Tang Shuangshuang Li Yuan Zhao Cunli Liu Xuenan Gu Yubo Fan | 2022 | Bioactive Materials2022，7，1： | 1 |
| 17 | Nanoencapsulation via Interfacially Confined Reversible Addition Fragmentation Transfer (RAFT) Miniemulsion Polymerization显示文摘 | Luo Yingwu Gu Hongyan | 2007 | Polymer2007，48，11： | 1 |
| 18 | Efficacy evaluation and mechanism of Bacillus subtilis EBS03 against cotton Verticillium wilt显示文摘Background:In our previous study,a strain EBS03 with good biocontrol potential was screened out of 48 strains of cotton endophyte Bacillus subtilis by evaluating the controlling effect against cotton Verticillium wilt.However,its mechanism for controlling Verticillium wilt remains unclear.The objective of this study was to further clarify its con-trolling effect and mechanism against cotton Verticillium wilt.Results:The results of confrontation culture test and double buckle culture test showed that the inhibitory effects of EBS03 volatile and nonvolatile metabolite on mycelium growth of Verticillium dahliae were 70.03%and 59.00%,respectively;the inhibitory effects of sporulation and microsclerotia germination were 47.16%and 70.06%,respec-tively.In the greenhouse test,the EBS03 fermentation broth root irrigation had the highest controlling effect at 87.11%on cotton Verticillium wilt,and significantly promoted the growth of cotton seedlings.In the field experi-ment,the controlling effect of EBS03 fermentation broth to cotton Verticillium wilt was 42.54%at 60 days after cotton sowing,and the boll number per plant and boll weight in EBS03 fermentation broth seed soaking,root irrigation,and spraying treatments significantly increased by 19.48%and 7.42%,30.90%and 2.62%,15.99%and 9.20%,respec-tively.Furthermore,EBS03 improved the resistance of cotton leaves against the infection of V.dahliae,and induced the outbreak of reactive oxygen species and accumulation of callose.In addition,the results of real time fluorescent quantitative polymerase chain reaction(RT-qPCR)detection showed that EBS03 significantly induced upregulation expression level of defense-related genes PAL,POD,PPO,and PR10 in cotton leaves,enhanced cotton plant resistance to V.dahliae,and inhibited colonization level of this fungal pathogen in cotton.Conclusion:Bacillus subtilis EBS03 has a good biological defense capability,which can inhibit the growth and coloni-zation level of V.dahliae,and activate the resistance of cotton to Verticillium wilt,thus increase cotton yield. | BAI Hongyan FENG Zili ZHAO Lihong FENG Hongjie WEI Feng ZHOU Jinglong GU Aixing ZHU Heqin PENG Jun ZHANG Yalin | 2022 | Journal of Cotton Research2022，5，4： | 1 |
| 19 | HOXA10 is Overexpressed in Human Ovarian Clear Cell Adenocarcinoma and Correlates With Poor Survival显示文摘 | Bin Li Hongyan Jin Yinhua Yu Chao Gu Xianrong Zhou Naiqing Zhao Youji Feng | 2009 | International Journal of Gynecological Cancer2009，，8： | 1 |
| 20 | Recommendations for the diagnosis and treatment of paroxysmal kinesigemc dyskinesia: an expert consensus in China显示文摘Paroxysmal dyskinesias are a group of neurological diseases characterized by intermittent episodes of involuntary movements with different causes.Paroxysmal kinesigenic dyskinesia(PKD)is the most common type of paroxysmal dyskinesia and can be divided into primary and secondary types based on the etiology.Clinically,PKD is characterized by recurrent and transient attacks of involuntary movements precipitated by a sudden voluntary action.The major cause of primary PKD is genetic abnormalities,and the inheritance pattern of PKD is mainly autosomal-dominant with incomplete penetrance.The proline-rich transmembrane protein 2(PRRT2)was the first identified causative gene of PKD,accounting for the majority of PKD cases worldwide.An increasing number of studies has revealed the clinical and genetic characteristics,as well as the underlying mechanisms of PKD.By seeking the views of domestic experts,we propose an expert consensus regarding the diagnosis and treatment of PKD to help establish standardized clinical evaluation and therapies for PKD.In this consensus,we review the clinical manifestations,etiology,clinical diagnostic criteria and therapeutic recommendations for PKD,and results of genetic analyses in PKD patients performed in domestic hospitals. | Li Cao Xiaojun Huang Ning Wang Zhiying Wu Cheng Zhang Weihong Gu Shuyan Cong Jianhua Ma Ling Wei Yanchun Deng Qi Fang Qi Niu Jin Wang Zhaoxia Wang You Yin Jinyong Tian Shufen Tian Hongyan Bi Hong Jiang Xiaorong Liu Yang Lu Meizhen Sun Jianjun Wu Erhe Xu Tao Chen Tao Chen Xu Chen Wei Li Shujian Li Qinghua Li Xiaonan Song Ying Tang Ping Yang Yun Yang Min Zhang Xiong Zhang Yuhu Zhang Ruxu Zhang Yi Ouyang Jintai Yu Quanzhong Hu Qing Ke Yuanrong Yao Zhe Zhao Xiuhe Zhao Guohua Zhao Furu Liang Nan Cheng Jianhong Han Rong Peng Shengdi Chen Beisha Tang | 2021 | Translational Neurodegeneration2021，10，1： | 1 |
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