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| 1 | Effects of dietary supplementation of Artemisia argyi aqueous extract on antioxidant indexes of small intestine in broilers显示文摘The present study was conducted to investigate the effect of Artemisia argyi aqueous extract(AAE) on antioxidant indexes in the small intestine. A total of 192 Arbor Acre broiler chickens(one-day-old) were randomly divided into 4 treatments with 6 replicates of 8 chickens. These 4 diets were formulated by adding 0, 500,1,000 and 2,000 mg/kg AAE to the basal diet. The results showed as follows: 1) compared with the control, the total antioxidant capacity(T-AOC) in ileum for the 2,000 mg/kg treatment group was significantly increased at 21 days of age(P < 0.05); the T-AOC levels in jejunum and ileum were significantly increased in broilers supplemented with 500 mg/kg AAE at 42 days of age(P < 0.05), and the T-AOC levels in jejunum and ileum were significantly improved in 1,000 mg/kg treatment group(P < 0.01), 2) At 21 days of age, supplementation of 500 mg/kg AAE significantly increased the catalase(CAT) activity of small intestine, and the glutathione peroxidase(GSH-Px) activity of jejunum was improved(P < 0.01), meanwhile, the GSH-Px activity of duodenum and the total superoxide dismutase(T-SOD) activity of duodenum and jejunum were significantly higher than those of the control group(P < 0.05); supplementation of 1,000 mg/kg AAE significantly increased the CAT activity of duodenum and ileum and the GSH-Px activity of duodenum and jejunum(P < 0.05), and the ileum GSH-Px activity was significantly increased(P < 0.01); supplementation of 2,000 mg/kg AAE significantly increased the CAT activity of duodenum and ileum(P < 0.05). At 42 days of age, supplementation of 500 mg/kg AAE significantly increased the GSH-Px activity of ileum and the T-SOD activity of duodenum(P < 0.05),meanwhile, the T-SOD activity of jejunum was significantly increased(P < 0.01); supplementation of1,000 mg/kg AAE significantly increased the CAT activity of jejunum and the T-SOD activity of ileum(P < 0.01), and the GSH-Px activity of jejunum was significantly increased(P < 0.05); supplementation of2,000 mg/kg AAE significantly increased the T-SOD activity of ileum(P < 0.05), but significantly decreased the CAT activity of ileum and the GSH-Px activity of jejunum(P < 0.05). 3) The malondialdehyde(MDA) levels of 3 AAE supplementation groups were significantly decreased at 21 and 42 days of age(P < 0.05). The results suggested that dietary supplementation with AAE could improve the antioxidative capacity of small intestine in broilers. | Fei Zhao Binlin Shi Dengsheng Sun Hongyan Chen Manman Tong Pengfei Zhang Xiaoyu Guo Sumei Yan | 2016 | Animal Nutrition2016，，3： | 18 |
| 2 | Salvage therapy with lenalidomide containing regimen for relapsed/refractory Castleman disease: a report of three cases显示文摘Castleman 疾病(CD ) 是有未知病原学的不平常的非同种细胞的 lymphoproliferative 混乱。没有标准治疗为 relapsed/refractory CD 病人被推荐,因此要求新奇试验性的途径的开发。我们有 multicentric CD (MCD ) 的三个成年病人的队被对待与对传统的化疗包含 lenalidomide 政体倔强(1025 mg lenalidomide perorally 在天管理了 121 在 28 天的周期) 作为第二 -- 到第四线的治疗。部分宽恕在第一个血浆房间 CD 病人被完成, relapsed 在自体同源的造血的干细胞移植以后的七个月然后没能对化疗的四个周期作出回应。organomegaly,部分宽恕与 CD 和 polyneuropathy 在第二个病人被获得 endocrinopathy, monoclonal gammopathy,和皮肤变化症候群。第三个案例与血小板计数的肋膜的流出和腹水和正规化的完全的消失显示出完全的宽恕。得出结论,令人鼓舞的临床的回答与基于 lenalidomide 的政体在三个病人的队被完成,不过,长期的功效尚待被遵守。我们在对待 MCD 建议这药的治疗学的潜力的进一步的调查。 | Xinping Zhou Juying Wei Yinjun Lou Gaixiang Xu Min Yang Hui Liu Liping Mao Hongyan Tong Jie Jin | 2017 | Frontiers of Medicine2017，11，2： | 6 |
| 3 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 4 | Efficacy and prognostic factors of imatinib plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphia chromosome-positive acute lymphoblastic leukemia显示文摘一个 CALLG2008 协议被中国尖锐成淋巴细胞的白血病合作的组为成年尖锐成淋巴细胞的白血病(所有) 开发。我们回顾地与费城染色体(Ph ) 分析了 153 个最新诊断的成年病人积极加在 2009 和 2015 之间的 CALLG2008 政体注册进 imatinib (400 mg/d ) 的所有。中部的年龄是 40 年(范围, 1868 年) ,与 81 (52.3%) 男性。全面 hematologic 完全的宽恕(CR ) 率在正式就职以后是 96.7% 。与 24.2 个月的中部的后续,估计的 3 年的全面幸存(OS ) 和没有事件的幸存(EFS ) 评价是 49.5%(95% 信心间隔(CI ) :38.5%59.5%) 并且 49.2%(95% CI:38.3%59.2%) 分别地。58 (36 与 haploidentical 施主) 病人们经历了 allogeneic 在第一 CR 的造血的干细胞移植(allo-HSCT ) 。在在在正式就职以后的 CR1 的病人之中, 3 年的 OS 和 EFS 比在 without allo-HSCT 组在 allo-HSCT 组显著地更好(73.2% , 95% CI:58.3%83.5% 对 22.2% , 95% CI:8.7%39.6% 并且 66.5% , 95% CI:50.7%78.2% 对 16.1% , 95% CI:5.1%32.7% ,分别地) 。Multivariate 分析显示出那 allo-HSCT,主要分子的反应的成就独立地与有利 OS 或 EFS 被联系。在 allo-HSCT 队,有趣地,施主类型(haploidentical 对匹配的施主) 没在 EFS 或 OS 上有重要影响。所有这些结果建议加 CALLG2008 的那 imatinib 是一个有效协议为 Ph 积极所有。Haploidentical 施主能也是一个合理其他的有用施主水池。 | Yinjun Lou Yafang Ma Chenyin Li Sansan Suo Hongyan Tong Wenbin Qian Wenyuan Mai Haitao Meng Wenjuan Yu Liping Mao Juyin Wei Weilei Xu Jie Jin | 2017 | Frontiers of Medicine2017，11，2： | 3 |
| 5 | Subtyping of type A influenza by sequencing the variable regions of HA gene specifically amplified with RT-PCR显示文摘The outbreak of a novel influenza A(H1N1) virus across the globe poses a threat to human health.It is of paramount importance to develop a rapid,reliable and inexpensive diagnostic procedure.Based on the bioinformatic information from public database,primers specific for influenza A virus surface protein haemagglutinin(HA) of several subtypes(including H1,H2,H3,H5,H7 and H9) were designed.Primer-specific PCR products were subjected to sequencing for accurately distinguishing H1 and H3 subtypes from others.This sequencing-based detection method will not only be applied to rapid detection and simultaneous subtype identification of new influenza A virus H1N1,but also provide the strategies to monitor other new types ofinfluenza virus with explosive potential. | YAN An DING GuoHui ZHOU ZhenFeng DONG Hui ZHANG YaKun ZHU Lei HE YunGang ZHANG GuoQing LI YiXue SUN Bing HUANG Zhong LAN Ke JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenGan ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN WeiRong XIONG Hui | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 6 | The mutation network for the hemagglutinin gene from the novel influenza A (H1N1) virus显示文摘A mutation network for the hemagglutinin gene(HA) of the novel type A(H1N1) influenza virus was constructed.Sequence homology analysis indicated that one HA sequence type from the viruses mainly isolated from Mexico was likely the original type in this epidemic.Based on the 658A and 1408T mutations in HA,the viruses evolving into this epidemic were divided into three categories,the Mexico,the transitional and the New York type.The three groups of viruses presented distinctive clustering features in their geographic distributions. | HE YunGang DING GuoHui BIAN Chao HUANG Zhong LAN Ke SUN Bing WANG XueCai LI YiXue WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang JIN WeiRong XIONG Hui DAI JianXin GUO YaJun WANG Hao CHE XiaoYan WU Fan YUAN ZhenAn ZHANG Xi CAO ZhiWei ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi ZHAO GuoPing JIN Li | 2009 | Chinese Science Bulletin2009，54，13： | 3 |
| 7 | Diagnosis and management of acquired thrombotic thrombocy- topenic purpura in southeast China: a single center experience of 60 cases显示文摘 | Xinping Zhou XingnongYe Yanling Ren Chen Mei Liya Ma Jiansong Huang Weilai Xu Juying Wei Li Ye Wenyuan Mai Wenbin Qian Haitao Meng Jie Jin Hongyan Tong | 2016 | Frontiers of Medicine2016，10，4： | 2 |
| 8 | Structure modeling and spatial epitope analysis for HA protein of the novel H1N1 influenza virus显示文摘In recent months,a novel influenza virus H1N1 broke out around the world.With bioinformatics technology,the 3D structure of HA protein was obtained,and the epitope residues were predicted with the method developed in our group for this novel flu virus.58 amino acids were identified as potential epitope residues,the majority of which clustered at the surface of the globular head of HA protein.Although it is located at the similar position,the epitope of HA protein for the novel H1N1 flu virus has obvious differences in the electrostatic potential compared to that of HA proteins from previous flu viruses. | WU Di XU TianLei SUN Jing DAI JianXin DING GuoHui HE YunGang ZHOU ZhengFeng XIONG Hui DONG Hui JIN WeiRong BIAN Chao JIN Li WANG HongYan WANG XiaoNing YANG Zhong ZHONG Yang WANG Hao CHE XiaoYan HUANG Zhong LAN Ke SUN Bing WU Fan YUAN ZhenAn ZHANG Xi ZHOU XiaoNong ZHOU JiaHai MA ZhiYong TONG GuangZhi GUO YaJun ZHAO GuoPing LI YiXue CAO ZhiWei | 2009 | Chinese Science Bulletin2009，54，13： | 2 |
| 9 | Fabricating multi-porous carbon anode with remarkable initial coulombic efficiency and enhanced rate capability for sodium-ion batteries显示文摘Due to the abundant sodium reserves and high safety,sodium ion batteries(SIBs)are foreseen a promising future.While,hard carbon materials are very suitable for the anode of SIBs owing to their structure and cost advantages.However,the unsatisfactory initial coulombic efficiency(ICE)is one of the crucial blemishes of hard carbon materials and the slow sodium storage kinetics also hinders their wide application.Herein,with spherical nano SiO_(2)as pore-forming agent,gelatin and polytetrafluoroethylene as carbon sources,a multi-porous carbon(MPC)material can be easily obtained via a co-pyrolysis method,by which carbonization and template removal can be achieved synchronously without the assistance of strong acids or strong bases.As a result,the MPC anode exhibited remarkable ICE of 83%and a high rate capability(208 m Ah/g at 5 A/g)when used in sodium-ion half cells.Additionally,coupling with Na3V2(PO4)3as the cathode to assemble full cells,the as-fabricated MPC//NVP full cell delivered a good rate capability(146 m Ah/g at 5 A/g)as well,implying a good application prospect the MPC anode has. | Yong Tong Yuanji Wu Zihao Liu Yongshi Yin Yingjuan Sun Hongyan Li | 2023 | Chinese Chemical Letters2023，34，1： | 2 |
| 10 | Identification of two novel B cell epitopes on porcine epidemic diarrhea virus spike protein显示文摘 | Dongbo Sun Li Feng Hongyan Shi Jianfei Chen Xiaochen Cui Hongyan Chen Shengwang Liu Youen Tong Yunfeng Wang Guangzhi Tong | 2008 | Veterinary Microbiology2008，，1： | 2 |
| 11 | Expression Profile and Function Analysis of Long Non-coding RNAs in the Infection of Coxsackievirus B3显示文摘The roles of IncRNAs in the infection of enteroviruses have been barely demonstrated.In this study,we used coxsackievirus B3(CVB3),a typical enterovirus,as a model to investigate the expression profiles and functional roles of IncRNAs in enterovirus infection.We profiled IncRNAs and mRNA expression in CVB3-infected HeLa cells by IncRNA-mRNA integrated microarrays.As a result,700 differentially expressed IncRNAs(431 up-regulated and 269 down-regulated)and 665 differentially expressed mRNAs(299 up-regulated and 366 down-regulated)were identified in CVB3 infection.Then we performed IncRNA-mRNA integrated pathway analysis to identify potential functional impacts of the differentially expressed mRNAs,in which IncRNA-mRNA correlation network was built.According to IncRNA-mRNA correlation,we found that XLOC-001188,an IncRNA down-regulated in CVB3 infection,was negatively correlated with NFAT5 mRNA,an anti-CVB3 gene reported previously.This interaction was supported by qPCR detection following siRNA-mediated knockdown of XLOC-001188,which showed an increase of NFAT5 mRNA and a reduction of CVB3 genomic RNA.In addition,we observed that four most significantly altered IncRNAs,SNHG11,RP11-145F16.2,RP11-1023L17.1 and RP11-1021N1.2 share several common correlated genes critical for CVB3 infection,such as BRE and IRF2BP1.In all,our studies reveal the alteration of IncRNA expression in CVB3 infection and its potential influence on CVB3 replication,providing useful information for future studies of enterovirus infection. | Lei Tong Ye Qiu Hui Wang Yunyue Qu Yuanbo Zhao Lexun Lin Yan Wang Weizhen Xu Wenran Zhao Hongyan He Guangze Zhao Mary HZhang Decheng Yang Xingyi Ge Zhaohua Zhong | 2019 | Virologica Sinica2019，34，6： | 2 |
| 12 | High Capacity and Fast Kinetics of Potassium‑Ion Batteries Boosted by Nitrogen‑Doped Mesoporous Carbon Spheres显示文摘In view of rich potassium resources and their working potential,potassium-ion batteries(PIBs)are deemed as next generation rechargeable batteries.Owing to carbon materials with the preponderance of durability and economic price,they are widely employed in PIBs anode materials.Currently,porosity design and heteroatom doping as efficacious improvement strategies have been applied to the structural design of carbon materials to improve their electrochemical performances.Herein,nitrogen-doped mesoporous carbon spheres(MCS)are synthesized by a facile hard template method.The MCS demonstrate larger interlayer spacing in a short range,high specific surface area,abundant mesoporous structures and active sites,enhancing K-ion migration and diffusion.Furthermore,we screen out the pyrolysis temperature of 900°C and the pore diameter of 7 nm as optimized conditions for MCS to improve performances.In detail,the optimized MCS-7-900 electrode achieves high rate capacity(107.9 mAh g^(−1) at 5000 mA g^(−1))and stably brings about 3600 cycles at 1000 mA g^(−1).According to electrochemical kinetic analysis,the capacitive-controlled effects play dominant roles in total storage mechanism.Additionally,the full-cell equipped MCS-7-900 as anode is successfully constructed to evaluate the practicality of MCS. | Jiefeng Zheng Yuanji Wu Yong Tong Xi Liu Yingjuan Sun Hongyan Li Li Niu | 2021 | Nano-Micro Letters2021，13，11： | 2 |
| 13 | Item-level Forecasting for E-commerce Demand with High-dimensional Data Using a Two-stage Feature Selection Algorithm显示文摘With the rapid development of information technology and fast growth of Internet users,e-commerce nowadays is facing complex business environment and accumulating large-volume and highdimensional data.This brings two challenges for demand forecasting.First,e-merchants need to find appropriate approaches to leverage the large amount of data and extract forecast features to capture various factors affecting the demand.Second,they need to efficiently identify the most important features to improve the forecast accuracy and better understand the key drivers for demand changes.To solve these challenges,this study conducts a multi-dimensional feature engineering by constructing five feature categories including historical demand,price,page view,reviews,and competition for e-commerce demand forecasting on item-level.We then propose a two-stage random forest-based feature selection algorithm to effectively identify the important features from the high-dimensional feature set and avoid overfittlng.We test our proposed algorithm with a large-scale dataset from the largest e-commerce platform in China.The numerical results from 21,111 items and 109 million sales observations show that our proposed random forest-based forecasting framework with a two-stage feature selection algorithm delivers 11.58%,5.81%and 3.68%forecast accuracy improvement,compared with the Autoregressive Integrated Moving Average(ARIMA),Random Forecast,and Random Forecast with one-stage feature selection approach,respectively,which are widely used in literature and industry.This study provides a useful tool for the practitioners to forecast demands and sheds lights on the B2C e-commerce operations management. | Hongyan Dai Qin Xiao Nina Yan Xun Xu Tingting Tong | 2022 | Journal of Systems Science and Systems Engineering2022，31，2： | 1 |
| 14 | The Study of Relationships between the Damage of Visual Function and Hemorrheology, Ocular Rheography, as well as Other Related Factors in Patients with Primary Open Angle Glaucoma (POAG)显示文摘Researches of glaucoma visual function damage, hemorrheololgy, ocular rheography and other related multiplex factors, with computed multifactorial stepwise regresion analysis, indicate that the elevation of intraocular pressure (IOP) is not the only factor to induce visual impairment. POAG patients are shown to have markedly reduced diastolic purfussion pressure in ophthalmic artery, besides prolonged filling time of the retinal artery and vein, diminished erythrocyte deformability and increased platele... | Jian Ge, Wenbing Zhou National Ophthalmological Laboratories, Ministry of Public Health, China, Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Sciences, Guangzhou 510060, China Jiancu Zhu, Anheng Cheng, Yulan Lin, Hongyan Tong, Lin Lian, Zhixing Chen Institute of Cardiovascular Diseases of Guangdong Province, Guangzhou 510080, China | 1993 | 眼科学报1993，9，1： | 1 |
| 15 | Adsorption of Acid Red G dye on octadecyl trimethylammonium montmorillonite显示文摘 | Dong Shen Tong Chun Hui (Clayton) Zhou Yan Lu Hongyan Yu Guo Fei Zhang Wei Hua Yu | 2010 | Applied Clay Science2010，，3： | 1 |
| 16 | Identification of two novel B cell epitopes on porcine epidemic diarrhea virus spike protein显示文摘 | Dongbo Sun Li Feng Hongyan Shi Jianfei Chen Xiaochen Cui Hongyan Chen Shengwang Liu Youen Tong Yunfeng Wang Guangzhi Tong | 2008 | Veterinary Microbiology2008，，1： | 1 |
| 17 | Indirect competitive enzyme-linked immunosorbent assay of tris-(2,3-dibromopropyl) isocyanurate with monoclonal antibody显示文摘 | Hongyan Feng Xi Tong Weili Li Liping Zhou Lei Shi Qingyun Cai | 2014 | Talanta2014，，： | 1 |
| 18 | High efficacy of arsenic trioxide plus all-trans retinoic acid based induction and maintenance therapy in newly diagnosed acute promyelocytic leukemia显示文摘 | Yinjun Lou Wenbin Qian Haitao Meng Wenyuan Mai Hongyan Tong Yin Tong Jian Huang Jie Jin | 2013 | Leukemia Research2013，，： | 1 |
| 19 | Antagonistic Effects of Sphingomonas and Pseudomonas aeruginosa on 4 Kinds of Pathogenic Bacteria of Ginseng显示文摘[Objectives]To explore effective biocontrol methods for diseases in the process of ginseng cultivation,and develop an efficient and environmentally friendly biocontrol agent.[Methods]In this study,2 strains were isolated from biogas slurry,and Cylindrocarpon destructans(XF),Fusarium solani(GF),Botrytis cinerea Pers(HM)and Alternaria panax Whetz(HB)were used as test materials.The strains were isolated and identified by dilution plate method,16S rDNA sequence identification method,confrontation culture method,filter paper method and ultraviolet spectrophotometer method,and the bacteriostatic activity and bacteriostatic rate were tested.[Results]Strain 15(Sphingomonas)and strain 19(Pseudomonas aeruginosa)were screened out through identification and analysis,and they grew stably within 8-10 d.The bacteriostatic rates of strain 15 against A.panax and B.cinerea were 47.37%and 43.40%,respectively,and the bacteriostatic rates of strain 19 against A.panax and B.cinerea were 62.30%and 63.27%,respectively.The bacteriostatic activity of the extract of strain 19 increased with the increase of OD_(600) value,and the bacteriostatic effect was optimal when the OD_(600) value was in the range of 0.8-1.0,up to 70%,so it had a strong biocontrol potential.[Conclusions]This experiment provides convenience for more effective inoculation,establishes a fast,simple and accurate method for the determination of the best bacteriostatic rate of P.aeruginosa culture solution to HM,and lays a foundation for large-scale culture of P.aeruginosa culture solution.Besides,it is expected to provide a theoretical basis for the efficient control of ginseng B.cinerea in field production,use it for the prevention and control of ginseng shoot diseases,and provide a reference for the efficient and diverse development of biocontrol agents for ginseng shoot diseases. | Hairu YU Feifan YAN Yunlong WANG Xinying TONG Di CHEN Qiang YE Renzhe PIAO Hongyan ZHAO | 2022 | Asian Agricultural Research2022，14，5： | 1 |
| 20 | The deubiquitinase USP11 promotes ovarian cancer chemoresistance by stabilizing BIP显示文摘Dear Editor,Chemoresistance is a major problem in the treatment of ovarian cancer patients and leads to poor prognosis,but its underlying mechanism remains elusive.Accumulating evidences have found that the aberrant regulation of the protein ubiquitination pathway plays an essential role in ovarian cancer chemoresistance.13 However,it is unclear whether and how deubiquitinase-USP11 involves in ovarian cancer chemoresistance. | Xiaolin Zhu Yiping Zhang Qingyu Luo Xiaowei Wu Furong Huang Tong Shu Yong Wan Hongyan Chen Zhihua Liu | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 1 |
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