|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer显示文摘Metformin is currently a strong candidate anti-tumor agent in multiple cancers.However,its anti-tumor effectiveness varies among different cancers or sub-populations,potentially due to tumor heterogeneity.It thus remains unclear which hepatocellular carcinoma(HCC)patient subpopulation(s)can benefit from met-formin treatment.Here,through a genome-wide CRISPR-Cas9-based knockout screen,we find that DOCK1 levels determine the anti-tumor effects of met-formin and that DOCK1 is a synthetic lethal target of metformin in HCC.Mechanistically,metformin promotes DOCK1 phosphorylation,which activates RAC1 to facilitate cell survival,leading to metformin resistance.The DOCK1-selective inhibitor,TBOPP,potentiates anti-tumor activity by metformin in vitro in liver cancer cell lines and patient-derived HCC organoids,and in vivo in xenografted liver cancer cells and immunocompetent mouse liver cancer models.Notably,metformin improves overall survival of HCC patients with low DOCK1 levels but not among patients with high DOCK1 expression.This study shows that metformin effective-ness depends on DOCK1 levels and that combining metformin with DOCK1 inhibition may provide a promising personalized therapeutic strategy for met-formin-resistant HCC patients. | Junru Feng Hui Lu Wenhao Ma Wenjing Tian Zhuan Lu Hongying Yang Yongping Cai Pengfei Cai Yuchen Sun Zilong Zhou Jiaqian Feng Jiazhong Deng Ying Shu Kun Qu Weidong Jia Ping Gao Huafeng Zhang | 2022 | Protein & Cell2022，13，11： | 5 |
| 2 | Rational development of a human antibody cocktail that deploys multiple functions to confer Pan-SARS-CoVs protection显示文摘Structural principles underlying the composition and synergistic mechanisms of protective monoclonal antibody cocktails are poorly defined.Here,we exploited antibody cooperativity to develop a therapeutic antibody cocktail against SARS-CoV-2.On the basis of our previously identified humanized cross-neutralizing antibody H014,we systematically an a lyzed a fully human n aive antibody library and rationally identified a potent neutralizing antibody partner,P17,which confers effective protection in animal model.Cryo-EM studies dissected the nature of the P17 epitope,which is SARS-CoV-2 specific and distinctly different from that of HOI4.High-resolution structure of the SARS-CoV-2 spike in complex with HOM and P17,together with functional investigations revealed that in a two-antibody cocktail,synergistic neutralization was achieved by S1 shielding and conformational locking,thereby blocking receptor attachment and viral membrane fusion,conferring high potency as well as robustness against viral mutation escape.Furthermore,cluster analysis identified a hypothetical 3rd antibody partner for further reinforcing the cocktail as pan-SARS-CoVs therapeutics. | Hangping Yao Yao Sun Yong-Qiang Deng Nan Wang Yongcong Tan Na-Na Zhang Xiao-Feng Li Chao Kong Yan-Peng Xuc Qi Chen Tian-Shu Cao Hui Zhao Xintian Yan Lei Cao Zhe Lv Dandan Zhu Rui Feng Nanping Wu Wenhai Zhang Yuhao Hu Keda Chen Rong-Rong Zhang Qingyu Lv Shihui Sun Yunhua Zhou Run Yan Guan Yang Xinglu Chanjuan Liu Xiangyun Lu Linfang Cheng Hongying Qiu Xing-Yao Huang Tianhao Weng Danrong Shi Weidong Jiang Junbin Shao Lei Wang Jie Zhang Tao Jiang Guojun Lang Cheng-Feng Qinc Lanjuan Li Xiangxi Wang | 2021 | Cell Research2021，31，1： | 5 |
| 3 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 4 | Methods of Studying Petroleum Systems in Residual Basins-A Case Study of Mesozoic and Palaeozoic MarineBasins in Southern China显示文摘 | ZHAO Zongju, ZHU Yan, YANG Shufeng, WANG Genghai,XU Yunjun, FENG Jialiang and DENG Hongying Department of Geoscience, Zhejiang University, Hangzhou 310027, Zhejiang Hangzhou Institute of Petroleum Geology, Hangzhou 310023, Zhejiang Zhou Jian Fei Zhenbi | 2002 | Acta Geologica Sinica(English Edition)2002，76，2： | 4 |
| 5 | China's foreign aid for global poverty alleviation:artemisinin-based combination therapies against malaria in Togo显示文摘From providing funds for the global fight against infectious diseases,to actively participating in global health security actions,to strengthening mutual cooperation in the field of health,and providing medical treatment,training and scholarships to countries in need,China’s foreign aid on global poverty alleviation is increasingly diversified and expanding in scale.Indeed,China is playing an increasingly important leading role in the global health agenda.It is worth mentioning that over the years,artemisinin compound have saved millions of lives all over the world,especially in poverty-stricken areas.China’s work mode of malaria elimination has also been written into WHO’s technical documents and recommended to other countries.Since 2007,Chinese medical staff has carried out the Artemisinin Compound Malaria Control Project in Comoros,bringing Chinese prevention and treatment programs to the local area.By 2014,Comoros had achieved zero deaths from malaria,and the number of cases had dropped by 98%.Now,this program is also extended to Togo,another African country.This article preliminarily summarizes the malaria profile in Togo and introduces China-Togo Cooperative Artemisinin Malaria Control Demonstration Project to provide a reference for better anti-malaria assistance in Togo,and also shows one of the substantive actions of China’s participation in global health governance,which contributes Chinese wisdom and offers Chinese solutions to global poverty alleviation. | Qi Wang Chuyi Yu Hongying Zhang Shaoqin Zheng Jianping Song Changsheng Deng | 2021 | Global Health Journal2021，5，3： | 3 |
| 6 | Optimal planning of harmonic filters on distribution systems by chance constrained programming显示文摘 | Yong Zhao Hongying Deng Jianhua Li | 2004 | Electric Power Systems Research2004，，68： | 1 |
| 7 | Aqueous phase catalytic hydrodechlorination of 4-chlorophenol over palladium deposited on reduced graphene oxide显示文摘 | Hongying Deng Guangyin Fan Chenyu Wang Lei Zhang | 2013 | Catalysis Communications2013，，： | 1 |
| 8 | Separation of two constituents from purple sweet potato by combination of silica gel column and high-speed counter-current chromatography显示文摘 | Kai He Xiaoli Ye Xuegang Li Hongying Chen Lujiang Yuan Yafei Deng Xin Chen Xiaoduo Li | 2011 | Journal of Chromatography B2011，，： | 1 |
| 9 | Experience and inspirations of the Mass Drug Administration Programme with artemisinin-piperaquine in Moheli Island of the Comoros assisted by China显示文摘Malaria is one of the major diseases threatening the lives of people in Africa.Over the past decade,China has provided anti-malaria assistance to Africa.In November 2007,fast control malaria team of Guangzhou University of Chinese Medicine cooperated with the Comoros health authority.In Moheli Island of the Comoros,the anti-malaria team adopted a new strategy of Mass Drug Administration(MDA)and active intervention.They established an e ective anti-malaria system and reporting system,as well as a local anti-malaria team.Furthermore,they treated patients with malaria in Moheli Island and implemended health education in local people.In a very short time,they have achieved remarkable results.This paper summarized the experiences of the project in order to provide useful reference for China to better carry out anti-malaria action in Africa and expand foreign health assistance. | Qi Wang Yueming Yun Hongying Zhang Jiawen Guo Wanting Wu Changsheng Deng Bo Huang Zhiyong Xu Qin Xu Jianping Song | 2018 | Global Health Journal2018，2，3： | 1 |
| 10 | Optimal plan-ning of harmonic filters on distribution systems by chance constrained programming 显示文摘 | Yong Zhao Hongying Deng Jianhua Li | 2004 | Electric Power Systems Research2004，，68： | 1 |
| 11 | Over-expression of genes and proteins of ubiquitin specific peptidases (USPs) and proteasome subunits (PSs) in breast cancer tissue observed by the methods of RFDD-PCR and proteomics显示文摘 | Shishan Deng Hongying Zhou Ruohong Xiong Youguang Lu Dazhong Yan Tianyong Xing Lihua Dong Enjie Tang Huijun Yang | 2007 | Breast Cancer Research and Treatment2007，，1： | 1 |
| 12 | 甲羟戊酸通路是疫苗佐剂研发的可药化靶点显示文摘文章简介佐剂是疫苗的一部分,能帮助疫苗更快速、持久地产生免疫应答。在现代疫苗的研发中,佐剂有着不可或缺的作用。但是到目前为止,FDA批准上市的佐剂只有铝佐剂,MF-59,AS03以及AS04等几种。 | 夏贇 谢永华 于正森 Hongying Xiao Guimei Jiang Xiaoying Zhou Yunyun Yang Xin Li Meng Zhao Liping Li Mingke Zheng Shuai Han Zhaoyun Zong Xianbin Meng Haiteng Deng Huahu Ye Yunzhi Fa Haitao Wu Eric Oldfield Xiaoyu Hu 刘万里 石彦 张永辉 | 2019 | 科学新闻2019，0，2： | 0 |
| 13 | Cable-driven legged landing gear for unmanned helicopter:Prototype design,optimization and performance assessment显示文摘Unmanned helicopters equipped with adaptive landing gear will dramatically extend their application especially in dealing with challenging terrains.This study presents a novel cable-driven legged landing gear(CLG)with differential transmission for unmanned helicopters in complex landing environments.To obtain the preferred configuration of the legged mechanism,a multi-objective optimization framework for the CLG is constructed by concurrently considering terrain adaptability,landing stability and reasonable linkage of internal forces.The non-dominated sorting genetic algorithmⅡis employed to numerically acquire the optimal scale parameters that guide the mechanical design of the CLG.An unmanned helicopter prototype equipped with the devised CLG is developed with key performance assessment.Experimental results show that the devised CLG can provide energy-efficient support over uneven terrains(totally driven torque demand less than 0.1 N m)in quasi-static landing tests,and favorable terrain adaptability(posture fluctuation of the fuselage less than±1°)in unknown slope landing tests.These exhibited merits give the proposed CLG the potential to enhance the landing performance of future aircraft in extreme environments. | TIAN BaoLin GAO HaiBo YU HaiTao SHAN HaoMin HOU JunChen YU HongYing DENG ZongQuan | 2024 | Science China(Technological Sciences)2024，67，4： | 0 |
| 14 | Application Advantages of Fan-Water Curtain Cooling System in Pig Production显示文摘[Objectives]The purpose was to solve the problem that high temperature and high humidity will seriously affect the health and weight gain of pigs.[Methods]The fan-water curtain cooling system was popularized in large-scale pig farms.[Results]The pigs using the water curtain cooling system gained 1.5 kg from weaning to the day of slaughter.The feed-to-gain ratio was 2.43∶1,a year-on-year decrease of 0.05.The average weight gain per pig was about 5-10 kg.[Conclusions]The application of fan-water curtain cooling system in pig production can accelerate the growth rate of pigs,reduce the occurrence of diseases and improve the utilization of feed,eventually improving the productivity of pigs. | Taiyin LI Jiarong WU Kejun LIU Hongying DENG Zhengyu CHEN Qisheng YANG Chunhua HUANG | 2020 | Asian Agricultural Research2020，12，6： | 0 |
| 15 | Clinical Efficacy and Application Progress of Reduning Injection in Children with Viral Encephalitis显示文摘Viral encephalitis in children caused by multiple viral infections,as a common central nervous system disease in pediatrics,has a high incidence in China.Its clinical symptoms usually include infection,poisoning,intracranial hypertension,and disturbance of consciousness.In severe cases,it can even endanger the lives of patient children.At present,the clinical treatment of the viral encephalitis mainly uses traditional Chinese medicine preparations such as Reduning Injection.The efficacy is significant.It can not only relieve the uncomfortable symptoms in a short time,but also has low incidence of adverse reactions.In this study,the factors that cause viral encephalitis in children were analyzed,and the efficacy,pharmacological action and clinical application of Reduning Injection were comprehensively elaborated,to provide a reference for clinical doctors to rationally treat viral encephalitis in children. | Yuanyuan ZOU Hongying ZHANG Zhiyong XU Ziyi PAN Changsheng DENG Jianping SONG Qi WANG | 2021 | Medicinal Plant2021，12，2： | 0 |
| 16 | 血压变化和空气污染微粒的化学成分显示文摘[背景]血压升高与颗粒物(PM)空气污染相关,但是与PM化学成分的关联尚不明确。[目的]通过对一组39名大学生进行460次反复访查,探讨血压与不同化学成分的细颗粒物(PM2.5)之间的关联。 | Shaowei Wu Furong Deng Jing Huang Hongyi Wang Masayuki Shima Xin Wang Yu Qin Chanjuan Zheng Hongying Wei Yu Hao Haibo Lv Xiuling Lu Xinbiao Guo | 2013 | 环境与职业医学2013，30，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员