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| 1 | Performance of a completely autotrophic nitrogen removal over nitrite process for treating wastewater with different substrates at ambient temperature显示文摘The stability and parameters of a bio-ceramic filter for completely autotrophic nitrogen removal were investigated.The completely autotrophic nitrogen removal over nitrite(CANON) reactor was fed with different concentrations of ammonia(400,300,and 200mg N/L) but constant influent ammonia load.The results showed that the CANON system can achieve good treatment performance at ambient temperature(15-23°C).The average removal rate and removal loading of NH4+-N and TN was 83.90%,1.26kg N/(m3·day),and 70.14%,1.09kg N/(m3·day),respectively.Among the influencing factors like pH,dissolved oxygen and alkalinity,it was indicated that the pH was the key parameter of the performance of the CANON system.Observing the variation of pH would contribute to better control of the CANON system in an intuitive and fast way.Denaturing gradient gel electrophoresis analysis of microorganisms further revealed that there were some significant changes in the community structure of ammonium oxidizing bacteria,which had low diversity in different stages,while the species of anaerobic ammonium oxidizing(anammox) bacteria were fewer and the community composition was relatively stable.These observations showed that anaerobic ammonia oxidation was more stable than the aerobic ammonia oxidation,which could explain that why the CANON system maintained a good removal efficiency under the changing substrate conditions. | Xiaoyan Chang Dong Li Yuhai Liang Zhuo Yang Shaoming Cui Tao Liu Huiping Zeng Jie Zhang | 2013 | Journal of Environmental Sciences2013，25，4： | 12 |
| 2 | The influence of nitroglycerin on the proliferation of endothelial progenitor cells from peripheral blood of patients with coronary artery disease显示文摘Endothelial 祖先房间(EPC ) 与脉管的修理和动脉粥样硬化患者损害的前进被联系。如果传播 EPC 失去他们的函数,它可以导致冠的动脉疾病(CAD ) 。连续硝化甘油(NTG ) 治疗原因增加了脉管的氧化应力和 endothelial 机能障碍。这研究的目的是在人的外部导出血的 EPC 的增长上调查 NTG 的效果。EPC 文化,从 60 个 CAD 病人镇定、为 712 天有教养,分别地为 72 h 与 NTG (0.0, 0.3, 1.0, 2.0, 7.5, 15.0,和 20.0 mg/l ) 的不同集中被对待。房间计数和 EPC 的 proliferative 活动;脉管的 endothelial 生长因素的层次 -- 一(VEGF -- 一) ,氮的氧化物(没有) 并且 peroxynitrite (在文化媒介的 ONOO ) ;并且在支持者房间的反应的氧种类(ROS ) 的水平被测量。与控制(0.0 mg/l NTG ) 相比,当与 1.0 mg/l NTG 对待并且当 NTG 集中是 7.5 mg/l 时,到达了最大的水平时, EPC 的房间数字和 proliferative 活动被增加。然而,当与 NTG (15.0 mg/l ) 的更高的剂量对待时,有重要减小。同时, VEGF -- 表情与 7.5 mg/l NTG 到达了它的最大的表示,但是逐渐地与 NTG 的更高的剂量由孵化衰退了。在没有水平和 NTG 集中之间有一种线性关系,但是当 EPC 与 0.37.5 mg/l NTG 被孵化时, ONOO 的变化和 ROS 层次都没被发现。然而,当与 15 和 20 mg/l NTG 孵化了时, ONOO 和 ROS 层次显著地被增加。我们的数据证明 NTG 的那中等剂量可以刺激从 CAD 病人孤立的 EPC 的 proliferative 活动。 | Xin Wang Caiyu Zeng Huiping Gong Hong He Mengxin Wang Qin Hu Falin Yang | 2014 | Acta Biochimica et Biophysica Sinica2014，46，10： | 4 |
| 3 | Entinostat,a classⅠselective histone deacetylase inhibitor,plus exemestane for Chinese patients with hormone receptor-positive advanced breast cancer:A multicenter,randomized,double-blind,placebo-controlled,phase 3 trial显示文摘Entinostat plus exemestane in hormone receptor-positive(HR+)advanced breast cancer(ABC)previously showed encouraging outcomes.This multicenter phase 3 trial evaluated the efficacy and safety of entinostat plus exemestane in Chinese patients with HR+ABC that relapsed/progressed after≥1 endocrine therapy.Patients were randomized(2:1)to oral exemestane 25 mg/day plus entinostat(n=235)or placebo(n=119)5 mg/week in 28-day cycles.The primary endpoint was the independent radiographic committee(IRC)-assessed progression-free survival(PFS).The median age was 52(range,28—75)years and 222(62.7%)patients were postmenopausal.CDK4/6 inhibitors and fulvestrant were previously used in 23(6.5%)and 92(26.0%)patients,respectively.The baseline characteristics were comparable between the entinostat and placebo groups.The median PFS was 6.32(95%CI,5.30—9.11)and 3.72(95%CI,1.91—5.49)months in the entinostat and placebo groups(HR,0.76;95%CI,0.58—0.98;P=0.046),respectively.Grade≥3 adverse events(AEs)occurred in 154(65.5%)patients in the entinostat group versus 23(19.3%)in the placebo group,and the most common grade≥3 treatment-related AEs were neutropenia[103(43.8%)],thrombocytopenia[20(8.5%)],and leucopenia[15(6.4%)].Entinostat plus exemestane significantly improved PFS compared with exemestane,with generally manageable toxicities in HR+ABC(ClinicalTrials.gov#NCT03538171). | Binghe Xu Qingyuan Zhang Xichun Hu Qing Li Tao Sun Wei Li Quchang Ouyang Jingfen Wang Zhongsheng Tong Min Yan Huiping Li Xiaohua Zeng Changping Shan Xian Wang Xi Yan Jian Zhang Yue Zhang Jiani Wang Liang Zhang Ying Lin Jifeng Feng Qianjun Chen Jian Huang Lu Zhang Lisong Yang Ying Tian Hongyan Shang | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 3 |
| 4 | Impact of total organic carbon and chlorine to ammonia ratio on nitrification in a bench-scale drinking water distribution system显示文摘Nitrification occurs in chloraminated drinking water systems and is affected by water quality parameters.The aim of this study was to investigate the impact of total organic carbon and chlorine to ammonia ratio on nitrification potential in a simulated drinking water distribution system as during chloramination.The occurrence of nitrification and activity of nitrifying bacteria was primarily monitored using four rotating annular bioreactors(RAB)with different chlorine to ammonia ratios and total organic carbon(TOC)levels.The results indicated that nitrification occurred despite at a low influent concentration of ammonia,and a high concentration of nitrite nitrogen was detected in the effluent.The study illustrated that reactors 1(R1)and 3(R3),with higher TOC levels,produced more nitrite nitrogen,which was consistent with the ammonia-oxidizing bacteria(AOB)counts,and was linked to a relatively more rapid decay of chloramines in comparison to their counterparts(R2 and R4).The AOB and HPC counts were correlated during the biofilm formation with the establishment of nitrification.Biofilm AOB abundance was also higher in the high TOC reactors compared with the low TOC reactors.The chlorine to ammonia ratio did not have a significant impact on the occurrence of nitrification.Bulk water with a high TOC level supported the occurrence of nitrification,and AOB development occurred at all examined chlorine to ammonia dose ratios(3:1 or 5:1). | Yongji ZHANG Lingling ZHOU Guo ZENG Huiping DENG Guibai LI | 2010 | Frontiers of Environmental Science & Engineering2010，4，4： | 3 |
| 5 | Multiscale windowed Fourier transform for phase extraction of fringe pat- terns显示文摘 | Zhong Jingang Zeng Huiping | 2007 | Applied Optics2007，46，： | 1 |
| 6 | Local frequency and phase analysis of interferogram显示文摘 | Zeng Huiping Zhong Jingang | 2005 | SPIE2005，6150，61： | 1 |
| 7 | Efficient Semi‑Transparent Wide‑Bandgap Perovskite Solar Cells Enabled by Pure‑Chloride 2D‑Perovskite Passivation显示文摘Wide-bandgap(WBG)perovskite solar cells suffer from severe non-radiative recombination and exhibit relatively large opencircuit voltage(V_(OC))deficits,limiting their photovoltaic performance.Here,we address these issues by in-situ forming a well-defined 2D perovskite(PMA)_(2)PbCl_(4)(phenmethylammonium is referred to as PMA)passivation layer on top of the WBG active layer.The 2D layer with highly pure dimensionality and halide components is realized by intentionally tailoring the side-chain substituent at the aryl ring of the post-treatment reagent.First-principle calculation and single-crystal X-ray diffraction results reveal that weak intermolecular interactions between bulky PMA cations and relatively low cation-halide hydrogen bonding strength are crucial in forming the well-defined 2D phase.The(PMA)_(2)PbCl_(4)forms improved type-I energy level alignment with the WBG perovskite,reducing the electron recombination at the perovskite/hole-transport-layer interface.Applying this strategy in fabricating semi-transparent WBG perovskite solar cells(indium tin oxide as the back electrode),the V_(OC)deficits can be reduced to 0.49 V,comparable with the reported state-of-the-art WBG perovskite solar cells using metal electrodes.Consequently,we obtain hysteresis-free 18.60%-efficient WBG perovskite solar cells with a high V_(OC)of 1.23 V. | Liu Yang Yongbin Jin Zheng Fang Jinyan Zhang Ziang Nan Lingfang Zheng Huihu Zhuang Qinghua Zeng Kaikai Liu Bingru Deng Huiping Feng Yujie Luo Chengbo Tian Changcai Cui Liqiang Xie Xipeng Xu Zhanhua Wei | 2023 | Nano-Micro Letters2023，15，8： | 1 |
| 8 | Biodiversity and quantification of functional bacteria in completely autotrophic nitrogen-removal over nitrite (CANON) process 显示文摘 | LIU Tao LI Dong ZENG Huiping | 2012 | Bioresouree Technol2012，118，： | 1 |
| 9 | Stability and nitrite-oxidizing bacteria community structure in different high-rate CANON reactors显示文摘 | Yuhai Liang Dong Li Xiaojing Zhang Huiping Zeng Zhuo Yang Shaoming Cui Jie Zhang | 2014 | Bioresource Technology2014，，： | 1 |
| 10 | Homocysteine accelerates hepatocyte autophagy by upregulating TFEB via DNMT3b-mediated DNA hypomethylation显示文摘Autophagy plays a critical role in the physiology and pathophysiology of hepatocytes.High level of homocysteine(Hcy)promotes autophagy in hepatocytes,but the underlying mechanism is still unknown.Here,we investigate the relationship between Hcy-induced autophagy level and the expression of nuclear transcription factor EB(TFEB).The results show that Hcy-induced autophagy level is mediated by upregulation of TFEB.Silencing of TFEB decreases the level of autophagy-related protein LC3BII/I and increases p62 expression level in hepatocytes after exposure to Hcy.Moreover,the effect of Hcy on the expression of TFEB is regulated by hypomethylation of the TFEB promoter catalyzed by DNA methyltransferase 3b(DNMT3b).In summary,this study shows that Hcy can activate autophagy by inhibiting DNMT3b-mediated DNA methylation and upregulating TFEB expression.These findings provide another new mechanism for Hcy-induced autophagy in hepatocytes. | Anning Yang Wen Zeng Hongwen Zhang Yinju Hao Qingqing Wang Yue Sun Shangkun Quan Ning Ding Xiaoling Yang Jianmin Sun Huiping Zhang Bin Liu Yun Jiao Kai Wu Yideng Jiang | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 11 | Effects of Different Nitrogen Levels on Growth and Nitrogen Utilization of Sugarcane显示文摘[Objectives]To systematically study the effects of different nitrogen levels on the growth and nitrogen utilization of sugarcane in Guangxi.[Methods]Through field experiment and indoor analysis,different nitrogen application levels were set up to determine soil nitrogen content and sugarcane nitrogen content.The effects of different nitrogen levels on sugarcane yield,agronomic characters and nitrogen utilization were studied.[Results]The effect of nitrogen application rate on sugarcane yield showed a quadratic curve,and nitrogen application could significantly increase sugarcane yield,and the sugarcane yield reached the maximum when the nitrogen application rate reached 714 kg/ha.[Conclusions]With the increase of nitrogen application rate,sugarcane yield increased,but when it exceeded a certain range,the sugarcane yield decreased significantly. | Jiayu PENG Huiping QU Jinsheng HUANG Liuqiang ZHOU Rulin XIE Xiaohui ZHU Yan ZENG Hongwei TAN | 2022 | Asian Agricultural Research2022，14，4： | 0 |
| 12 | Nutritional Elements Related to Leaf Blight of Pearl Plum in Longtan Town显示文摘[Objectives]This study was conducted to investigate the correlation between leaf blight of pearl plum and nutrient elements from the perspective of plant nutrition.[Methods]Branch and leaf samples of pearl plum plants infected by or free of leaf blight and the corresponding 0-30 cm cultivated soil were collected,and statistical analysis was conducted according to the changes in nutrient contents and the incidence of leaf blight,so as to look for nutrients in pearl plum plants associated with leaf blight,as well as soil constraint factors.[Results]Phosphorus,iron and manganese in nutrients may be related to leaf blight,and the factors affecting leaf blight may be the ratios of P/Fe and P/Mn in leaves.[Conclusions]This study provides a basis for further research on the relationship between phosphorus,iron and manganese on the effect of leaf blight in pearl plum trees. | Xiaohui ZHU Jinsheng HUANG Yan ZENG Liuqiang ZHOU Rulin XIE Jiayu PENG Huiping OU Zhongning LI Hongmei LU | 2022 | Agricultural Biotechnology2022，11，4： | 0 |
| 13 | The Measurements of Highly Stripped Bromine Atom Spectra显示文摘Spectraofhighlyionizedbromineatomweremeasuredbymeansofbeam-foilmethodintheHI-13tandemaceleratorlaboratoryatChinaInstituteAtom... | Zeng Xiantang Li Jingwen Hu Aidong Jiang Liyang Du ShubinDepartment of Nuclear Physics, CLAE, Beijing 102413Wang Youde Liu Huiping Ma XinwenInstitute of Moden Physics, Academia sinica, Lanzhou 730000 | 1998 | 原子与分子物理学报1998，15，S1： | 0 |
| 14 | CACA Guidelines for Holistic Integrative Management of Breast Cancer显示文摘Purpose:Breast cancer is now the most common malignant tumor worldwide.About one-fourth of female cancer patients all over the world sufer from breast cancer.And about one in six female cancer deaths worldwide is caused by breast cancer.In terms of absolute numbers of cases and deaths,China ranks frst in the world.The CACA Guidelines for Holistic Integrative Management of Breast Cancer were edited to help improve the diagnosis and comprehensive treatment in China.Methods:The Grading of Recommendations Assessment,Development and Evaluation(GRADE)was used to classify evidence and consensus.Results:The CACA Guidelines for Holistic Integrative Management of Breast Cancer include the epidemiology of breast cancer,breast cancer screening,breast cancer diagnosis,early breast cancer treatment,advanced breast cancer treatment,follow-up,rehabilitation,and traditional Chinese medicine treatment of breast cancer patients.Conclusion:We to standardize the diagnosis and treatment of breast cancer in China through the formulation of the CACA Guidelines. | Jiong Wu Daiming Fan Zhimin Shao Binghe Xu Guosheng Ren Zefei Jiang Yongsheng Wang Feng Jin Jin Zhang Qingyuan Zhang Fei Ma Jinli Ma Zhonghua Wang Shusen Wang Xiaojia Wang Shu Wang Haibo Wang Tao Wang Xiang Wang Jing Wang Jia Wang Biyun Wang Li Fu Hongyuan Li Yehui Shi Lu Gan Yunjiang Liu Jian Liu Zhenzhen Liu Qiang Liu Qiang Sun Wenwu Cheng Keda Yu Zhongsheng Tong Xinhong Wu Chuangui Song Jianguo Zhang Jian Zhang Junjie Li Bin Li Man Li Huiping Li Wentao Yang Hongjian Yang Benlong Yang Hong Bu Juping Shen Zhenzhou Shen Yiding Chen Ceshi Chen Da Pang Zhimin Fan Ying Zheng Xiaoli Yu Guangyu Liu Xichun Hu Yiqun Ling Jinhai Tang Yongmei Yin Cuizhi Geng Peng Yuan Yajia Gu Cai Chang Xuchen Cao Yuan Sheng Yuanxi Huang Jian Huang Weijun Peng Xiaohua Zeng Yuntao Xie Ning Liao Committee of Breast Cancer Society,Chinese Anti-Cancer Association | 2022 | Holistic Integrative Oncology2022，1，1： | 0 |
| 15 | A new generation M^(pro)inhibitor with potent activity against SARS-CoV-2 Omicron variants显示文摘Emerging SARS-CoV-2 variants, particularly the Omicron variant and its sublineages, continually threaten the global public health.Small molecule antivirals are an effective treatment strategy to fight against the virus. However, the first-generation antivirals eithershow limited clinical efficacy and/or have some defects in pharmacokinetic (PK) properties. Moreover, with increased use of thesedrugs across the globe, they face great pressure of drug resistance. We herein present the discovery and characterization of a newgeneration antiviral drug candidate (SY110), which is a potent and selective inhibitor of SARS-CoV-2 main protease (Mpro). Thiscompound displayed potent in vitro antiviral activity against not only the predominant SARS-CoV-2 Omicron sublineage BA.5, butalso other highly pathogenic human coronaviruses including SARS-CoV-1 and MERS-CoV. In the Omicron-infected K18-hACE2mouse model, oral treatment with SY110 significantly lowered the viral burdens in lung and alleviated the virus-induced pathology.Importantly, SY110 possesses favorable PK properties with high oral drug exposure and oral bioavailability, and also an outstandingsafety profile. Furthermore, SY110 exhibited sensitivity to several drug-resistance Mpro mutations. Collectively, this investigationprovides a promising new drug candidate against Omicron and other variants of SARS-CoV-2. | Chong Huang Huiping Shuai Jingxin Qiao Yuxin Hou Rui Zeng Anjie Xia Lingwan Xie Zhen Fang Yueyue Li Chaemin Yoon Qiao Huang Bingjie Hu Jing You Baoxue Quan Xiu Zhao Nihong Guo Shiyu Zhang Ronggang Ma Jiahao Zhang Yifei Wang Ruicheng Yang Shanshan Zhang Jinshan Nan Haixing Xu Falu Wang Jian Lei Hin Chu Shengyong Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 16 | Near 30%fractional bandwidth surface acoustic wave filters with novel electrode configuration显示文摘With the rapid progress of the wireless communication technique and the fast growing of the radio frequency(RF)markets,the development of wideband surface acoustic wave(SAW)filter is intensely pursued in RF front-end platforms.In this study,a novel configuration of SAW device was proposed in 15°YX-Li NbO_(3)(300 nm)/SiO_(2)(600 nm)/Si heterostructure,where the series and shunt resonator innovatively adopt Cu electrodes of different thickness to suppress the unwanted Rayleigh mode efficiently.Series and shunt resonators with clean spectrum and high electromechanical coupling coefficients over 20%were experimentally achieved under the guidance of finite element method calculation.Based on the resonator results,a ladder-type SAW filter with a very large 3-dB fractional bandwidth near 30%was successfully designed and fabricated.The minimum insertion loss of device is as small as 1.1 dB while the in-band fluctuation is less than 0.3 dB.The unprecedented wideband property of SAW device indicates that the proposed configuration is expected to become one of the solutions of wideband filter in fifth-generation mobile communication,and possess great application prospects. | Rongxuan Su Sulei Fu Zengtian Lu Junyao Shen Huiping Xu Hongqing Mao Zhibin Xu Cheng Song Fei Zeng Weibiao Wang Feng Pan | 2021 | Progress in Natural Science:Materials International2021，31，6： | 0 |
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