|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The immunotherapeutic effect of dendritic cells vaccine modified with interleukin-18 gene and tumor cell lysate on mice with pancreatic carcinoma显示文摘AIM:To estimate the effect of a therapeutic vaccine against pancreatic carcinoma based on dendritic cell(DC)vaccine modified with tumor lysate and Interleukin-18 gene.METHODS:The BALB/C mice model of pancreatic arcinoma was induced with DMBA,DCvaccine was construted through pulsed with tumor lysate and transfected by the recombinant adenoviral vector encoding IL-18gene.The immnotherapeutic effects of DC vaccine on mice with pancreatic carcinoma were assessed (divided intoD-IL18-Lysate group,DC-Lysate group,DC-IL18 group,DC group,PBSgroup).RESULTS:After vaccination of the DC vaccine,the concentration of IL-18and IFN-γwere 2161±439ng·L^-1and435±72ng·L^-1inDC-IL18-Lysate group and there was significant difference compared with other groups(P<0.01)After vaccination of the DCcvaccine,the transplanted tumors were observed on 30days inDC-Lysate groups.on 16daysinDC-IL18groups.on3days in control group,but mice remained tumor-free for at least50days in DC-IL18-Lysate group and there was significant difference between DC-IL18-Lysate group and other groups(P<0.01).The median survival exceeds62days in DC-IL18-Lysate group.But the medsian surival was 48.6days in DC-Lysate group,33days in DC-IL-18group,17days in PBSgroup.The survival period was obviously prolonged in DC-IL18-Lysate group than in other groups(P<0.05,P<0.01).The weight of pancreatic tumor was0.22±0.083ginDC-IL18-Lysate group,1.45±0.74ginDC-Lysate group,1.89±1.34gin DC-IL18group,3.0±1.6ginDCgroup,2.9±2.0ginPBSgroup and the weight of tumor obviously reduced in DC-IL-18-Lysate group than in other groups(P<0.05,P<0.01).CONCLUSION:DC vaccine modified with tumo lysate and Interleukin-18gene can induce a specific and effective immune response against pancreatic cancinoma,cell. | Zhao-Hui Tang Gao-Song Wu Sheng-Quan Zou Fa-Zhu Qiu Department of Surgery of Tong Ji Hospital Wen-Hong Qiu Department of immunology,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,Hubei Province,China Xiang-Ping Yang Department of Biochemistry,Rheinisch-Westfalische Technische Hochschule(RWTH),D-52074 Aachen,Germany | 2002 | World Journal of Gastroenterology2002，8，5： | 37 |
| 2 | Application of P507 and isooctanol extraction system in recovery of scandium from simulated red mud leach solution显示文摘The current recovery technique of Sc was complicated and the chemical consumption was high,This was due to the low content of Sc in resources and the difficulty of stripping.In this research,the isooctanol was added into the 2-ethylhexyl phosphonic acid mono-2-ethylhexyl ester(P507)extraction system to reduce the extraction and improve the stripping of Sc.The maximum stripping ratio of Sc from loaded organic phase by sulfuric acid can increase from 10%(without isooctanol)to 99%(with 15 vol%isooctanol).In the extraction test of the simulated red mud leaching liquor,the separation factors between Sc and Zr,Sc and Ti are 36 and 350,separately.At the same time,other metals are almost not extracted.The high selectivity and stripping of Sc suggest that the P507 with isooctanol extraction system can be applied in the practical Sc recovery process. | Chuanying Liu Li Chen Ji Chen Dan Zou Yuefeng Deng Deqian Li | 2019 | Journal of Rare Earths2019，37，9： | 22 |
| 3 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 4 | PERSPECTIVES IN MECHANICS OF HETEROGENEOUS SOLIDS显示文摘The Microand Nano-mechanics Working Group of the Chinese Society of Theoretical and Applied Mechanics organized a forum to discuss the perspectives,trends,and directions in mechanics of heterogeneous materials in January 2010.The international journal,Acta Mechanica Solida Sinica,is devoted to all fields of solid mechanics and relevant disciplines in science,technology,and engineering,with a balanced coverage on analytical,experimental,numerical and applied investigations.On the occasion of the 30 th anniversary of Acta Mechanica Solida Sinica,its editor-in-chief,Professor Q.S.Zheng invited some of the forum participants to review the state-of-the-art of mechanics of heterogeneous solids,with a particular emphasis on the recent research development results of Chinese scientists.Their reviews are organized into five research areas as reported in different sections of this paper.§I firstly brings in focus on microand nano-mechanics,with regards to several selective topics,including multiscale coupled models and computational methods,nanocrystal superlattices,surface effects,micromechanical damage mechanics,and microstructural evolution of metals and shape memory alloys.§II shows discussions on multifield coupled mechanical phenomena,e.g.,multi-fields actuations of liquid crystal polymer networks,mechanical behavior of materials under radiations,and micromechanics of heterogeneous materials.In §III,we mainly address the multiscale mechanics of biological nanocomposites,biological adhesive surface mechanics,wetting and dewetting phenomena on microstructured solid surfaces.The phononic crystals and manipulation of elastic waves were elaborated in §IV.Finally,we conclude with a series of perspectives on solid mechanics.This review will set a primary goal of future science research and engineering application on solid mechanics with the effort of social and economic development. | C.Q. Chen J.Z. Cui H.L. Duan X.Q. Feng L.H. He G.K. Hu M.J. Huang Y.Z. Huo B.H. Ji B. Liu X.H. Peng H.J. Shi Q.P. Sun J.X. Wang Y.S. Wang H.P. Zhao Y.P. Zhao Q.S. Zheng W.N. Zou | 2011 | Acta Mechanica Solida Sinica2011，24，1： | 18 |
| 5 | Wnt and BMP signaling crosstalk in regulating dental stem cells:Implications in dental tissue engineering显示文摘Tooth is a complex hard tissue organ and consists of multiple cell types that are regulated by important signaling pathways such as Wnt and BMP signaling.Serious injuries and/or loss of tooth or periodontal tissues may significantly impact aesthetic appearance,essential oral functions and the quality of life.Regenerative dentistry holds great promise in treating oral/dental disorders.The past decade has witnessed a rapid expansion of our understanding of the biological features of dental stem cells,along with the signaling mechanisms governing stem cell self-renewal and differentiation.In this review,we first summarize the biological characteristics of seven types of dental stem cells,including dental pulp stem cells,stem cells from apical papilla,stem cells from human exfoliated deciduous teeth,dental follicle precursor cells,periodontal ligament stem cells,alveolar bone-derived mesenchymal stem cells(MSCs),and MSCs from gingiva.We then focus on how these stem cells are regulated by bone morphogenetic protein(BMP)and/or Wnt signaling by examining the interplays between these pathways.Lastly,we analyze the current status of dental tissue engineering strategies that utilize oral/dental stem cells by harnessing the interplays between BMP and Wnt pathways.We also highlight the challenges that must be addressed before the dental stem cells may reach any clinical applications.Thus,we can expect to witness significant progresses to be made in regenerative dentistry in the coming decade. | Fugui Zhang Jinlin Song Hongmei Zhang Enyi Huang Dongzhe Song Viktor Tollemar Jing Wang Jinhua Wang Maryam Mohammed Qiang Wei Jiaming Fan Junyi Liao Yulong Zou Feng Liu Xue Hu Xiangyang Qu Liqun Chen Xinyi Yu Hue H.Luu Michael J.Lee Tong-Chuan He Ping Ji | 2016 | Genes & Diseases2016，3，4： | 16 |
| 6 | Postreperfusion syndrome during orthotopic liver transplantation:a single-center experience显示文摘BACKGROUND: Marked hemodynamic alteration, commonly referred to as postreperfusion syndrome (PRS), often occurs after revascularization of the donor organ during orthotopic liver transplantation (OLT) and is associated with poor outcomes. This study aimed to investigate the incidence, predictive factors and clinical outcomes of PRS in Chinese patients following OLT at a liver transplantation center in China. METHODS: Over a 5-year period, 330 consecutive patients who had undergone OLT for hepatocellular carcinoma or cirrhosis were included in this retrospective study. PRS was defined as a >30% decrease in the mean arterial pressure compared with that before revascularization for more than 1 minute during the first 5 minutes of graft reperfusion. The patients were divided into 2 groups according to the development of PRS: group 1 (patients with PRS, n=56) and group 2 (patients without PRS, n=274). The demographic characteristics, operative and postoperative courses, and outcomes of the patients were analyzed using SPSS version 18.0. RESULTS: Multivariate regression analysis showed that left ventricular diastolic dysfunction determined by echocardiography and prolonged cold ischemia time were the independent risk factors for PRS. More patients in group 1 showed postoperative renal dysfunction than those in group 2 (19.23% vs 8.4%). Moreover, patients in group 1 also had higher intraoperative (7.14% vs 0%) and postoperative mortalities (26.92% vs 12.04%).CONCLUSION: Left ventricular diastolic dysfunction and prolonged cold ischemia time contribute to a high incidence of PRS, which is associated with adverse outcomes in Chinese patients following OLT. | Zhen-Dong Xu, Hai-Tao Xu, Hong-Bin Yuan, Hao Zhang, Rui-Hua Ji, Zui Zou, Zhi-Ren Fu and Xue-Yin Shi Department of Anesthesiology, Huashan Hospital, Fudan University, Shanghai 200040, China Department of Anesthesiology Organ Transplantation Center , Changzheng Hospital, Second Military Medical University, Shanghai 200003, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，1： | 15 |
| 7 | Direct low-temperature synthesis of graphene on various glasses by plasma-enhanced chemical vapor deposition for versatile, cost-effective electrodes显示文摘在低温度的各种各样的玻璃底层上的 graphene 的没有催化剂、可伸缩的合成具有到象便宜透明电子学和最先进的显示器那样的众多的应用程序的首要的意义。然而,在这个有希望的研究领域以内的系统的学习远这样仍然保持少见。此处,我们用一个低温度的提高血浆的化学蒸汽免职方法在各种各样的眼镜上报导 graphene 的直接生长。如此的一条灵巧、可伸缩的途径在 400600 的一个生长温度范围在各种各样的玻璃底层上保证一致、没有转移的 graphene | Jingyu Sun Yubin Chen Xin Cai Bangjun Ma Zhaolong Chen Manish Kr. Priydarshi Ke Chen Teng Gao Xiuju Song Qingqing Ji Xuefeng Guo Dechun Zou Yanfeng Zhang Zhongfan Liu | 2015 | Nano Research2015，8，11： | 12 |
| 8 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 9 | Endoscopic findings of gastrointestinal involvement in Chinese patients with Behcet's disease显示文摘AIM:To report the incidence,clinical features and outcomes of gastrointestinal(GI)involvement in Behcet’s disease(BD).METHODS:A total of 168 consecutive patients with BD were screened and upper and lower GI endoscopies were performed in 148 patients.Four hundred age-and sex-matched controls were enrolled for comparison.RESULTS:Fifty-two(35.1%)patients had GI lesions.After a mean follow-up of 10 mo,ileocecal ulcers had been confirmed in 20 patients,including active ulcer(s)in 18 patients,but no ileocecal ulceration was found in controls.GI symptoms were present in 14 patients with active ulcer(s),while 4 patients with smaller ulcer were asymptomatic.Endoscopic features of ileocecalulcer were:a single ulcer(50%),larger than 1 cm in diameter(72.2%),and round/oval or volcano-type in shape(83.3%).Compared with patients without GI involvement,less ocular lesions,lower levels of albumin,erythrocyte count and hemoglobin,and higher levels of C-reactive protein and erythrocyte sedimentation rate were confirmed in the intestinal BD group.Four patients had esophageal ulcers in the BD group but no case in controls.The other endoscopic findings were similar between the two groups.The prevalence of Helicobacter pylori infection was similar in both groups.Most patients received an immunomodulator and responded well.CONCLUSION:GI lesions commonly occur in Chinese BD patients.The most frequently involved area is the ileocecal region.Esophageal ulcer might be a rare but unique lesion. | Jun Zou Yan Shen Da-Nian Ji Song-Bai Zheng Jian-Long Guan | 2014 | World Journal of Gastroenterology2014，20，45： | 10 |
| 10 | Graphitic Carbon Quantum Dots Modified Nickel Cobalt Sulfide as Cathode Materials for Alkaline Aqueous Batteries显示文摘Carbon quantum dots(CQDs)as a new class of emerging materials have gradually drawn researchers’concern in recent years.In this work,the graphitic CQDs are prepared through a scalable approach,achieving a high yield with more than 50%.The obtained CQDs are further used as structure-directing and conductive agents to synthesize novel N,S-CQDs/NiCo2S4 composite cathode materials,manifesting the enhanced electrochemical properties resulted from the synergistic effect of highly conductive N,S-codoped CQDs offering fast electronic transport and unique micro-/nanostructured NiCo2S4 microspheres with Faradaic redox characteristic contributing large capacity.Moreover,the nitrogen-doped reduced graphene oxide(N-rGO)/Fe2O3 composite anode materials exhibit ultrahigh specific capacity as well as significantly improved rate property and cycle performance originating from the high-capacity prism-like Fe2O3 hexahedrons tightly wrapped by highly conductive N-rGO.A novel alkaline aqueous battery assembled by these materials displays a specific energy(50.2 Wh kg^−1),ultrahigh specific power(9.7 kW kg^−1)and excellent cycling performance with 91.5%of capacity retention at 3 A g^−1 for 5000 cycles.The present research offers a valuable guidance for the exploitation of advanced energy storage devices by the rational design and selection of battery/capacitive composite materials. | Yirong Zhu Jingying Li Xiaoru Yun Ganggang Zhao Peng Ge Guoqiang Zou Yong Liu Hongshuai Hou Xiaobo Ji | 2020 | Nano-Micro Letters2020，12，2： | 10 |
| 11 | A Potential Disease Susceptibility Gene CsLOB of Citrus Is Targeted by a Major Virulence Effector PthA of Xanthomonas citri subsp, citri显示文摘Dear Editor, Citrus bacterial canker (CBC),one of the most destructive diseases of citrus,has a severe economic impact on citrus industries in tropical and subtropical countries (Das,2003).It has been widely known that Xanthomonas cirri subsp.cirri (Xcc) causes the CBC by transferring the type-Ⅲ effectors (T3SEs) to the interior of the plant cell through type-Ⅲ secretion system (T3S) to modulate transcription of host plants to trigger CBC disease (Schaad et al.,2006).Pathotype A,the Asiatic form of Xcc,has a wide host range,is pathogenic on almost all citrus varieties,and contains a major virulence gene pthA encoding a T3S-secreted transcriptional activator-like effector (TALE) that promotes cellular hypertrophy (Al-Saadi et al.,2007).However,the susceptibility gene in citrus being responsible for the CBC and matching PthA of Xcc is largely unknown. | Zheng Li Lifang Zou Gang Ye Li Xiong Zhiyuan Ji Muhammad Zakria Ni Hong Guoping Wang Gongyou Chen | 2014 | Molecular Plant2014，7，5： | 9 |
| 12 | Advances in ultra-high temperature ceramics,composites,and coatings显示文摘Ultra-high temperature ceramics(UHTCs)are generally referred to the carbides,nitrides,and borides of the transition metals,with the Group IVB compounds(Zr&Hf)and TaC as the main focus.The UHTCs are endowed with ultra-high melting points,excellent mechanical properties,and ablation resistance at elevated temperatures.These unique combinations of properties make them promising materials for extremely environmental structural applications in rocket and hypersonic vehicles,particularly nozzles,leading edges,and engine components,etc.In addition to bulk UHTCs,UHTC coatings and fiber reinforced UHTC composites are extensively developed and applied to avoid the intrinsic brittleness and poor thermal shock resistance of bulk ceramics.Recently,high-entropy UHTCs are developed rapidly and attract a lot of attention as an emerging direction for ultra-high temperature materials.This review presents the state of the art of processing approaches,microstructure design and properties of UHTCs from bulk materials to composites and coatings,as well as the future directions. | Dewei NI Yuan CHENG Jiaping ZHANG Ji-Xuan LIU Ji ZOU Bowen CHEN Haoyang WU Hejun LI Shaoming DONG Jiecai HAN Xinghong ZHANG Qiangang FU Guo-Jun ZHANG | 2022 | Journal of Advanced Ceramics2022，11，1： | 9 |
| 13 | Kinetics of nitric acid leaching of cerium from oxidation roasted Baotou mixed rare earth concentrate显示文摘The kinetics of nitric acid leaching of cerium was investigated for the oxidation roasted Baotou mixed rare earth concentrate. The effects of leaching temperature, HNO_3 concentration, liquidesolid ratio(L/S)and stirring rate on rare earth extraction were studied. The XRD and SEM mapping analysis of the samples before and after acid leaching shows that the roasted bastnaesite is completely leached. Besides,the decomposition process of oxidizing roasting was also obtained by TGe MS and XRD. Different kinetics models were applied in this leaching process. The results of dynamic fitting show that the leaching process can be described by a new variant of the shrinking-core model. And the leaching rate is controlled by both the interfacial transfer and diffusion through the product layer. The apparent activation energy is calculated as 76.78 kJ/mol and the reaction orders with respect to HNO_3 concentrations and liquidesolid ratio are determined to be 7.609 and 2.516, respectively. Besides, an empirical rate equation is obtained to describe the process. | Kai Li Ji Chen Dan Zou Tianchi Liu Deqian Li | 2019 | Journal of Rare Earths2019，37，2： | 8 |
| 14 | Effect of external stents on prevention of intimal hyperplasia in a canine vein graft model显示文摘背景外部 stents 被用来减少学习是由把静脉接枝与外部 stents.Methods 的不同尺寸作比较定义为特别接枝适当的外部 stent 的尺寸的礼品的静脉 grafts.The 目的内层的增生一系列配对的试用被执行把大腿骨的静脉接枝与作比较不同在 30 建模的 canines 同等地被划分成三groups:6公里的地方,外部 stents 缩放外部 stent 对 non-stent 控制,4公里对6公里外部 | ZOU Rong-jiang ZOU Liang-jian HUANG Sheng-dong WANG Yin HAN Lin JI Guang-yu XU Zhi-yun | 2007 | Chinese Medical Journal2007，，24： | 8 |
| 15 | Molten salt synthesis of porous carbon and its application in supercapacitors: A review显示文摘Carbon materials have taken an important role in supercapacitor applications due to their outstanding features of large surface area,low price,and stable physicochemical properties.Considerable research efforts have been devoted to the development of novel synthesis strategy for the preparation of porous carbon materials in recent years.In particular,molten salt strategy represents an emerging and promising method,whereby it has shown great potential in achieving tailored production of porous carbon.It has been proved that the molten salt-assisted production of carbon via the direct carbonization of carbonaceous precursors is an effective approach.Furthermore,with the incorporation of electrochemical technology,molten salt synthesis of porous carbon has become flexible and diversiform.Here,this review focuses on the mainstream molten salt synthesis strategies for the production of porous carbon materials,which includes direct molten salt carbonization process,capture and electrochemical conversion of CO_(2)to value-added carbon,electrochemical exfoliation of graphite to graphene-based materials,and electrochemical etching of carbides to new-type carbide-derived carbon materials.The reaction mechanisms and recent advances for these strategies are reviewed and discussed systematically.The morphological and structural properties and capacitive performances of the obtained carbon materials are summarized to reveal their appealing points for supercapacitor applications.Moreover,the opportunities and challenges of the molten salt synthesis strategy for the preparation of carbon materials are also discussed in this review to provide inspiration to the future researches. | Zhongya Pang Guangshi Li Xiaolu Xiong Li Ji Qian Xu Xingli Zou Xionggang Lu | 2021 | Journal of Energy Chemistry2021，30，10： | 7 |
| 16 | AZD9291-induced Acute Interstitial Lung Disease显示文摘To the Editor:A 32-year-old Chinese male patient with 1 week cough and dyspnea on exertion was presented to hospital.He was a metastatic lung adenocarcinoma patient with 3 years treatment history.In October 2012,the patient complained cough,short of breath,and thoracic computerized axial tomography scan (CAT-scan) revealed left lung hilum mass with the right lung multismall patches or opacities. | Ke-Ke Nie Xiao Zou Chuan-Xin Geng Ling Zhang Shi-Chao Liu Chun-Ling Zhang You-Xin Ji | 2016 | Chinese Medical Journal2016，，12： | 7 |
| 17 | SIMULATION AND EXPERIMENT OF BUBBLY FLOW INSIDE THROTTLING GROOVE显示文摘在在扼杀沟内的压力分发和成穴(噪音) 之间的关系被数字模拟和试验性的方法调查。有几个变换器的一个阀门衣袋被执行在阀门房间内检测压力分布,并且结果与计算液体动力学(CFD ) 适合相当好分析。高速度的成像技术被采用在扼杀的沟附近调查成穴机制,特别地水泡开始和簇形成。一个光谱分析器被用来测量水泡流动产生的噪音的健全压力水平。在沟内的压力分布对阀门港口配置和背压力敏感,这被发现。压力分发决定通过阀门沟和折叠水泡导致的噪音的健全压力水平的水泡尺寸和数字。入口压力主要因此在沟和健全压力水平的紧张内影响冒泡的流动的浸透度。 | FU Xin DU Xuewen ZOU Jun YANG Huayong JI Hong | 2007 | Chinese Journal of Mechanical Engineering2007，20，5： | 7 |
| 18 | Clinical features and the traditional Chinese medicine therapeutic characteristics of 293 COVID-19 inpatient cases显示文摘Coronavirus disease 2019 (COVID-19) is now pandemic worldwide and has heavily overloaded hospitals in Wuhan City, China during the time between late January and February. We reported the clinical features and therapeutic characteristics of moderate COVID-19 cases in Wuhan that were treated via the integration of traditional Chinese medicine (TCM) and Western medicine. We collected electronic medical record (EMR) data, which included the full clinical profiles of patients, from a designated TCM hospital in Wuhan. The structured data of symptoms and drugs from admission notes were obtained through an information extraction process. Other key clinical entities were also confirmed and normalized to obtain information on the diagnosis, clinical treatments, laboratory tests, and outcomes of the patients. A total of 293 COVID-19 inpatient cases, including 207 moderate and 86 (29.3%) severe cases, were included in our research. Among these cases, 238 were discharged, 31 were transferred, and 24 (all severe cases) died in the hospital. Our COVID-19 cases involved elderly patients with advanced ages (57 years on average) and high comorbidity rates (61%). Our results reconfirmed several well-recognized risk factors, such as age, gender (male), and comorbidities, as well as provided novel laboratory indications (e.g., cholesterol) and TCM-specific phenotype markers (e.g., dull tongue) that were relevant to COVID-19 infections and prognosis. In addition to antiviral/antibiotics and standard supportive therapies, TCM herbal prescriptions incorporating 290 distinct herbs were used in 273 (93%) cases. The cases that received TCM treatment had lower death rates than those that did not receive TCM treatment (17/273= 6.2% vs. 7/20= 35%, P = 0.0004 for all cases;17/77= 22% vs. 7/9= 77.7%, P = 0.002 for severe cases). The TCM herbal prescriptions used for the treatment of COVID-19 infections mainly consisted of Pericarpium Citri Reticulatae, Radix Scutellariae, Rhizoma Pinellia, and their combinations, which reflected the practical TCM principles (e.g., clearing heat and dampening phlegm). Lastly, 59% of the patients received treatment, including antiviral, antibiotics, and Chinese patent medicine, before admission. This situation might have some effects on symptoms, such as fever and dry cough. By using EMR data, we described the clinical features and therapeutic characteristics of 293 COVID-19 cases treated via the integration of TCM herbal prescriptions and Western medicine. Clinical manifestations and treatments before admission and in the hospital were investigated. Our results preliminarily showed the potential effectiveness of TCM herbal prescriptions and their regularities in COVID-19 treatment. | Zixin Shu Yana Zhou Kai Chang Jifen Liu Xiaojun Min Qing Zhang Jing Sun Yajuan Xiong Qunsheng Zou Qiguang Zheng Jinghui Ji Josiah Poon Baoyan Liu Xuezhong Zhou Xiaodong Li | 2020 | Frontiers of Medicine2020，14，6： | 7 |
| 19 | Petrology and metamorphism of glaucophane eclogites in Changning-Menglian suture zone, Bangbing area, southeast Tibetan Plateau: An evidence for Paleo-Tethyan subduction显示文摘High/ultrahigh-pressure(HP/UHP)metamorphic complexes,such as eclogite and blueschist,are generally regarded as significant signature of paleo-subduction zones and paleo-suture zones.Glaucophane eclogites have been recently identified within the Lancang Group characterized by accretionary mélange in the Changning-Menglian suture zone,at Bangbing in the Shuangjiang area of southeastern Tibetan Plateau.The authors report the result of petrological,mineralogical and metamorphism investigations of these rocks,and discuss their tectonic implications.The eclogites are located within the Suyi blueschist belt and occur as tectonic lenses in coarse-grained garnet muscovite schists.The major mineral assemblage of the eclogites includes garnet,omphacite,glaucophane,phengite,clinozoisite and rutile.Eclogitic garnet contains numerous inclusions,such as omphacite,glaucophane,rutile,and quartz with radial cracks around.Glaucophane and clinozoisite in the matrix have apparent optical and compositional zonation.Four stages of metamorphic evolution can be determined:The prograde blueschist facies(M_(1)),the peak eclogite facies(M_(2)),the decompression blueschist facies(M_(3))and retrograde greenschist facies(M_(4)).Using the Grt-Omp-Phn geothermobarometer,a peak eclogite facies metamorphic P-T condition of 3000–3270 MPa and 617–658℃ was determined,which is typical of low-temperature ultrahigh-pressure metamorphism.The comparison of the geological characteristics of the Bangbing glaucophane eclogites and the Mengku lawsonite-bearing retrograde eclogites indicates that two suites of eclogites may have formed from significantly different depths or localities to create the tectonic mélange in a subduction channel during subduction of the Triassic Changning-Menglian Ocean.The discovery of the Bangbing glaucophane eclogites may represent a new oceanic HP/UHP metamorphic belt in the Changning-Menglian suture zone. | Yu-zhen Fu Zhi-ming Peng Bao-di Wang Guo-zhi Wang Jing-feng Hu Jun-lei Guan Ji Zhang Zhang Zhang Yun-he Liu Zou Hao | 2021 | China Geology2021，4，1： | 7 |
| 20 | Identification of methylation profile of HOX genes in extrahepatic cholangiocarcinoma显示文摘AIM:To identify methylation profile and novel tumor marker of extrahepatic cholangiocarcinoma(CCA)with high throughout microarray.METHODS:Differential methylation profile was compared between normal bile duct epithelial cell lines and CCA cell lines by methyl-DNA immunoprecipitation (MeDIP)microarray.Bisulfite-polymerase chain reaction (BSP)was performed to identify the methylated allels of target genes.Expression of target genes was investigated before and after the treatment with DNA demethylating agent.Expression of candidate genes was also evaluated by immunofluorescence in 30 specimens of CCA tissues and 9 normal bile duct tissues.RESULTS:Methylation profile of CCA was identified with MeDIP microarray in the respects of different gene functions and signaling pathways.Interestingly,97 genes with hypermethylated CpG islands in the promoter region were homeobox genes.The top 5 hypermethylated homeobox genes validated by BSP were HOXA2(94.29%),HOXA5(95.38%),HOXA11 (91.67%),HOXB4(90.56%)and HOXD13(94.38%).Expression of these genes was reactivated with 5’-aza2’-deoxycytidine.Significant expression differences were found between normal bile duct and extrahepatic CCA tissues(66.67%-100%vs 3.33%-10%).CONCLUSION:HOXA2,HOXA5,HOXA11,HOXB4 and HOXD13 may work as differential epigenetic biomarkers between malignant and benign biliary tissues. | Yi Shu Bing Wang Ji Wang Jian-Ming Wang Sheng-Quan Zou | 2011 | World Journal of Gastroenterology2011，17，29： | 7 |
您所在的机构暂未开通此部分的功能，请联系管理员