|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Impact of one satellite outage on ARAIM depleted constellation configurations显示文摘Advanced Receiver Autonomous Integrity Monitoring(ARAIM) is a new technology that will provide worldwide coverage of vertical guidance in aviation navigation. The ARAIM performance and improvement under depleted constellations is a practical problem that needs to be faced and researched further. It is a shortcut that improves the availability in position domain whose key idea is to replace the conventional least squares process with a non-least-squares estimator to lower the integrity risk in exchange for a slight increase in nominal position error. The contributions given in this paper include two parts: First, the impacts of one satellite outage on different constellations are analyzed and compared. The conclusion is that GPS is more sensitive and vulnerable to one satellite outage. Second, a constellation weighted ARAIM(CW-ARAIM)position estimator is proposed. The position solution is replaced by a constellation weighted average solution to eliminate the constellation difference. The new solution will move close to the constellation solutions with respect to the accuracy requirement. The simulation results under baseline GPS and Galileo dual-constellation show that the one GPS satellite outage will knock the availability from 91% to only 50%. The performance remains stable with one Galileo satellite outage. With the assistance of the CW-ARAIM method, the availability can increase from 50% to more than80% under depleted GPS configurations. Even without any satellite outage, the proposed method can effectively improve the availability from 91.29% to 98.75%. The test results under optimistic constellations further verify that a balanced constellation is more important than more satellites on orbit and the superiority of CW-ARAIM method is still effective. | Qian MENG Jianye LIU Qinghua ZENG Shaojun FENG Rui XU | 2019 | Chinese Journal of Aeronautics2019，32，4： | 11 |
| 2 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules显示文摘Error-free mitosis depends on accurate chromosome attachment to spindle microtubules, powered congression of those chromosomes, their segregation in anaphase, and assembly of a spindle midzone at mitotic exit. The centromere-associated kinesin motor CENP-E, whose binding partner is BubR1, has been implicated in congression of misaligned chromosomes and the transition from lateral kinetochore-microtubule association to end-on capture. Although previously proposed to be a pseudokinase, here we report the structure of the kinase domain of Drosophila melanogaster BubR1, revealing its folding into a conformation predicted to be catalytically active. BubR1 is shown to be a bona fide kinase whose phosphorylation of CENP-E switches it from a laterally attached microtubule motor to a plus-end microtubule tip tracker. Computational modeling is used to identify bubristatin as a selective BubR1 kinase antagonist that targets the αN1 helix of N-terminal extension and αC helix of the BubR1 kinase domain. Inhibition of CENP-E phosphorylation is shown to prevent proper microtubule capture at kinetochores and, surprisingly, proper assembly of the central spindle at mitotic exit. Thus, BubR1-mediated CENP-E phosphorylation produces a temporal switch that enables transition from lateral to end-on microtubule capture and organization of microtubules into stable midzone arrays. | Yuejia Huang Lin Lin Xing Liu Sheng Ye Phil Y. Yao Wenwen Wang Fengrui Yang Xinjiao Gao Junying Li Yin Zhang Jiancun Zhang Zhihong Yang Xu Liu Zhenye Yang Jianye Zang Maikun Teng Zhiyong Wang Ke Ruan Xia Ding Lin Li Don W. Cleveland Rongguang Zhang Xuebiao Yao | 2019 | Cell Research2019，29，7： | 8 |
| 3 | Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms显示文摘 | Liu Ming Wang Jianye Yang Yong An Ruihua Wen Jianguo Guan Zhichen Zheng Shaobin Wang Dongwen Song Bo Liao Limin Guo Hongqian Xiao Jiaquan Sun Yinghao Shen Zhoujun Kong Chuize He Dalin Huang Yiran Wang Xiaofeng Zhang Xu Li Hanzhong Huang Jian Zhao Xiaokun Zeng Puqing Song Xishuang Ye Zhangqun | 2014 | Chinese Medical Journal2014，，2： | 7 |
| 4 | Morphological Characteristics of Sand Waves in the Middle Taiwan Shoal Based on Multi-beam Data Analysis显示文摘A DTM map of the study area in the Taiwan Shoal was drawn based on precise and highdensity data acquired in a field survey by a multi-beam sounding system(R2Sonic2024). We identified sand waves in the study area at water depths of 13.89–49.12 m; the main sand waves had heights of 5–25 m, lengths of 0.1–2.0 km, and crest lines 0.1–6.5 km long. The spatial distribution of the sand waves on the seabed is dense in the north and sparse in the south and the directions range between 50°–80° and 90°–135°. Between the main sand waves, secondary sand waves develop with heights of 0.1–5.0 m and lengths of 10–100 m, which are difficult to detect by satellite remote sensing. By comparing the evolution structures of the secondary and main sand waves, we identified three evolution modes of the secondary sand waves: parallel, oblique, and divergent modes according to the relative crest directions. Suitable water depth, reciprocating current speeds between 40 and 100 cm/s, and abundant sediment supply create favorable conditions for the formation of linear sand waves. Comparing the DTM maps and profiles of the June 2012 and June 2013 surveys of the same area, we found that the shape and morphology of the sand waves remained mostly unchanged under normal hydrodynamic conditions. | BAO Jingjing CAI Feng REN Jianye ZHENG Yongling WU Chengqiang LU Huiquan XU Yan | 2014 | Acta Geologica Sinica(English Edition)2014，88，5： | 5 |
| 5 | Secalonic acid D induces cell apoptosis in both sensitive and ABCG2-overexpressing multidrug resistant cancer cells through upregulating c-Jun expression显示文摘Secalonic acid D(SAD) could inhibit cell growth in not only sensitive cells but also multidrug resistant(MDR) cells. However, the molecular mechanisms need to be elucidated. Here, we identified that SAD possessed potent cytotoxicity in 3 pairs of MDR and their parental sensitive cells including S1-MI-80 and S1,H460/MX20 and H460, MCF-7/ADR and MCF-7 cells. Furthermore, SAD induced cell G2/M phase arrest via the downregulation of cyclin B1 and the increase of CDC2 phosphorylation. Importantly, JNK pathway upregulated the expression of c-Jun in protein level and increased c-Jun phosphorylation induced by SAD, which was linked to cell apoptosis via c-Jun/Src/STAT3 pathway. To investigate the mechanisms of upregulation of c-Jun protein by SAD, the mR NA expression level and degradation of c-Jun were examined. We found that SAD did not alter the mR NA level of c-Jun but inhibited its proteasome-dependent degradation. Taken together, these results implicate that SAD induces cancer cell death through c-Jun/Src/STAT3 signaling axis by inhibiting the proteasome-dependent degradation of c-Jun in both sensitive cells and ATP-binding cassette transporter sub-family G member 2(ABCG2)-mediated MDR cells. | Hong Zhang Liyan Huang Liyang Tao Jianye Zhang Fang Wang Xu Zhang Liwu Fu | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 5 |
| 6 | Quantifying 3D cell-matrix interactions during mitosis and the effect of anticancer drugs on the interactions显示文摘The mechanical force between cells and the extracellular microenvironment is crucial to many physiological processes such as cancer metastasis and stem cell differentiation. Mitosis plays an essential role in all these processes and thus an in-depth understanding of forces during mitosis gains insight into disease diagnosis and disease treatment. Here, we develop a traction force microscope method based on monolayer fluorescent beads for measuring the weak traction force (tens of Pa) of mitotic cells in three dimensions. We quantify traction forces of human ovarian granulosa (KGN) cells exerted on the extracellular matrix throughout the entire cell cycle in three dimensions. Our measurements reveal how forces vary during the cell cycle, especially during cell division. Furthermore, we study the effect of paclitaxel (PTX) and nocodazole (NDZ) on mitotic KGN cells through the measurement of traction forces. Our results show that mitotic cells with high concentrations of PTX exert a larger force than those with high concentrations of NDZ, which proved to be caused by changes in the structure and number of microtubules. These findings reveal the key functions of microtubule in generating traction forces during cell mitosis and explain how dividing cells regulate themselves in response to anti-mitosis drugs. This work provides a powerful tool for investigating cell-matrix interactions during mitosis and may offer a potential way to new therapies for cancer. | Yongman Liu Jianye Wang Yong Su Xiaohai Xu Hong Liu Kainan Mei Shihai Lan Shubo Zhang Xiaoping Wu Yunxia Cao Qingchuan Zhang Shangquan Wu | 2021 | Nano Research2021，14，11： | 3 |
| 7 | RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway显示文摘Gliomas are the most common central nervous system tumours;they are highly aggressive and have a poor prognosis. RGS16 belongs to the regulator of G-protein signalling (RGS) protein family, which plays an important role in promoting various cancers, such as breast cancer, pancreatic cancer, and colorectal cancer. Moreover, previous studies confirmed that let-7c-5p, a well-known microRNA, can act as a tumour suppressor to regulate the progression of various tumours by inhibiting the expression of its target genes. However, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7c-5p are still unknown. Here, we confirmed that RGS16 is upregulated in glioma tissues and that high expression of RGS16 is associated with poor survival. Ectopic deletion of RGS16 significantly suppressed glioma cell proliferation and migration both in vitro and in vivo. Moreover, RGS16 was validated as a direct target gene of miR let-7c-5p. The overexpression of miR let-7c-5p obviously downregulated the expression of RGS16, and knocking down miR let-7c-5p had the opposite effect. Thus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and may serve as a potential prognostic biomarker and therapeutic target in glioma. | Chaochao Wang Hao Xue Rongrong Zhao Zhongzheng Sun Xiao Gao Yanhua Qi Huizhi Wang Jianye Xu Lin Deng Gang Li | 2023 | Frontiers of Medicine2023，17，1： | 2 |
| 8 | A high dynamics algorithm based on steepest ascent method for GNSS receiver显示文摘High dynamic conditions impose critical challenges on Global Navigation Satellite System(GNSS)receivers,leading to large tracking errors or even loss of tracking.Current methods that intend to improve receivers’adaptability for high dynamics require either complicated structures or prior statistical information of noises.This paper proposes a high dynamics algorithm based on steepest ascent method that can circumvent the deficiencies of existing methods.First,the relationship between the error of carrier tracking and the maximum of Fast Fourier Transform(FFT)outputs is established,and a performance function based on the steepest ascent method is designed.It can keep stable in high dynamics.Second,a new carrier-tracking loop is constructed by deploying the performance function.When the variation of GPS receiver acceleration ranges from 10 g to 100 g,compared with the PLL that either loses lock or keeps tracking accuracy less than 33.89 Hz,the experimental results show that the proposed method can not only keep tracking,but also achieve tracking accuracy more than 2.77 Hz. | Qinghua ZENG Wenqi QIU Jianye LIU Rui XU Jinheng SHI Yongrong SUN | 2021 | Chinese Journal of Aeronautics2021，34，12： | 1 |
| 9 | SOLUTION OF SYSTEM OF FRACTIONAL DIFFERENTIAL EQUATIONS BY ADOMIAN DECOMPOSITION METHOD显示文摘这份报纸的目的是把相对新的 Adomian 分解方法用于解决系统线性部分,在 Riemann-Liouville 和 Caputo 的意义分别地,微分方程。解决方案以入学考试争论的 Mittag-Leffler 函数被表示。Adomian 分解方法是直接的,为更普遍的问题适用并且在使用不可分的变换避免困难。因为顺序是 1,这里的结果被简化到第一份订单的微分方程。 | Duan Junsheng An Jianye Xu Mingyu2 | 2007 | Applied Mathematics(A Journal of Chinese Universities)2007，22，1： | 1 |
| 10 | Spatial variability in soil heat flux at three Inner Mongolia steppe ecosystems显示文摘 | Changliang Shao Jiquan Chen Linghao Li Wenting Xu Shiping Chen Tenney Gwen Jianye Xu Wenli Zhang | 2008 | Agricultural and Forest Meteorology2008，，10： | 1 |
| 11 | Combined effects of cooled EGR and a higher geometric compression ratio on thermal efficiency improvement of a downsized boosted spark-ignition direct-injection engine显示文摘 | Jianye Su Min Xu Tie Li Yi Gao Jiasheng Wang | 2014 | Energy Conversion and Management2014，，： | 1 |
| 12 | Relationship between Thermal Metamorphism of Coal and the Periodic Variation Law of Geochemical Behavior of Elements:A Study on the C2 Coal Seam in the Fengfeng Mining Area of the Handan Coalfield in Hebei,China显示文摘This study highlights the response of the periodic variation of the geochemical behavior of elements to the thermal metamorphism of coal by considering the differentiation mode and differentiation degree of elements of the C2 coal seam in the Fengfeng mining area of the Handan Coalfield in Hebei,China.The periodic variation of the geochemical behavior of elements was observed to change towards a certain direction as the degree of metamorphism of a geological body increased.Based on the coincidence degree(or similarity degree)between the geochemical behavior of elements and periodic variation of elements,the 57 elements in this study were divided into two levels.The periodic variation of the geochemical behavior of first-level elements was largely synchronous with that of their first ionization energy,suggesting that only one differentiation mode exists and the elements are mainly inorganically associated.The differentiation mode of the second-level elements deviated to a certain extent from their first ionization energy;the larger the deviation,the more complicated and diverse was the differentiation mode.Among the second-level elements,the grade of coal metamorphism has evident and intuitive effects on the proportion of elements with particular structural features,such as the 4q+3 type of elements and the odd-odd elements.In addition,the distribution of elements in organic and inorganic matter within coal are subject to the structural features of the elements.The differentiation mode and differentiation intensity of elements could be characterized by the hierarchical parameter and differentiation intensity.The hierarchical parameter and differentiation intensity of certain elements showed a good positive or negative correlation with R_(max) in coal.The 57 elements in this study were quantitatively ordered according to the degree of magmatic hydrothermal fluid influence and thermal metamorphism of coal through graphs depicting the goodness of fit,correlation coefficient with R_(max),and differentiation intensity.The results of this study are consistent with the results of previous field research,illustrating the scientific significance and application value of this study on the periodic variation of the geochemical behavior of elements. | YANG Jianye QIN Shenjun ZHANG Weiguo LIU Shande XU Fei | 2021 | Acta Geologica Sinica(English Edition)2021，95，5： | 1 |
| 13 | Net primary production in three bioenergy crop systems following land conversion显示文摘Aims Identifying the amount of production and the partitioning to above-and belowground biomass is generally the first step toward select-ing bioenergy systems.There are very few existing studies on the dynamics of production following land conversion.The objectives of this study were to(i)determine the differences in aboveground net primary production(ANPP),belowground net primary produc-tion(BNPP),shoot-to-root ratio(S:R)and leaf area index in three bioenergy crop systems and(ii)evaluate the production of these three systems in two different land use conversions.Methods This investigation included biometric analysis of NPP on three agri-cultural sites converted from conservation reserve program(CRP)management to bioenergy crop production(corn,switchgrass and prairie mix)and three sites converted from traditional agriculture production to bioenergy crop production.Important findings The site converted from conventional agriculture produced smaller ANPP in corn(19.03±1.90 standard error[SE]Mg ha^(−1) year^(−1))than the site converted from CRP to corn(24.54±1.43 SE Mg ha^(−1) year^(−1)).The two land conversions were similar in terms of ANPP for switchgrass(4.88±0.43 SE for CRP and 2.04±0.23 SE Mg ha^(−1) year^(−1) for agriculture)and ANPP for prairie mix(4.70±0.50 SE for CRP and 3.38±0.33 SE Mg ha^(−1) year^(−1) for agriculture).The BNPP at the end of the growing season in all the bioenergy crop systems was not significantly different(P=0.75,N=8). | Michael W.Deal Jianye Xu Ranjeet John Terenzio Zenone Jiquan Chen Housen Chu Poonam Jasrotia Kevin Kahmark Jonathan Bossenbroek Christine Mayer | 2014 | Journal of Plant Ecology2014，7，5： | 0 |
| 14 | Hierarchical dual-porous hydroxyapatite doped dendritic mesoporous silica nanoparticles based scaffolds promote osteogenesis in vitro and in vivo显示文摘Biomaterial based scaffolds for treating large bone defects require excellent biocompatibility and osteoconductivity.Here we report on the fabrication of hydroxyapatite-dendritic mesoporous silica nanoparticles(HA-DMSN)based scaffolds with hierarchical micro-pores(5µm)and nano-pores(6.4 nm),and their application for bone regeneration.The in vitro studies demonstrated good biocompatibility of dissolution extracts,as well as enhanced osteogenic potential indicated by dose-dependent upregulation of bone marker gene expression(osteocalcin gene(OCN),osteopontin gene(OPN),collagen type I alpha 1 gene(CoL1A1),runt-related transcription factor 2 gene(RUNX2),and integrin-binding sialoprotein gene(IBSP)),alkaline phosphatise(ALP)activity,and alizarin red staining.The in vivo studies showed that HA-DMSN scaffolds significantly increased bone formation in a rat cranial bone defect model after 4 weeks healing.Our study provides a simple method to fabricate promising inorganic scaffolds with hierarchical pores for bone tissue engineering. | Chang Lei Yuxue Cao Sepanta Hosseinpour Fang Gao Jingyu Liu Jianye Fu Reuben Staples Saso Ivanovski Chun Xu | 2021 | Nano Research2021，14，3： | 0 |
| 15 | Fluoride removal from secondary effluent of the graphite industry using electrodialysis:Optimization with response surface methodology显示文摘Response surface methodology was utilized to model and optimize the operational variables for defluoridation using an electrodialysis process as the treatment of secondary effluent of the graphite industry. Experiments were conducted using a Box-Behnken surface statistical design in order to evaluate the effects and the interaction of the influential variables including the operational voltage, initial fluoride concentration and flow rate. The regression models for defluoridation and energy consumption responses were statistically validated using analysis of variance (ANOVA);high coefficient of determination values (R^2 = 0.9772 and R^2 = 0.9814;respectively) were obtained. The quadratic model exhibited high reproducibility and a good fit of the experimental data. The optimum values of the initial fluoride concentration, voltage and flow rate were found to be 13.9 mg/L, 13.4 V, 102.5 L/h, respectively. A fluoride removal efficiency of 99.69% was observed under optimum conditions for the treatment of the secondary effluent of the graphite industry. | Xiaomeng Wang Ning Li Jianye Li Junjun Feng Zhun Ma Yuting Xu Yongchao Sun Dongmei Xu Jian Wang Xueli Gao Jun Gao | 2019 | Frontiers of Environmental Science & Engineering2019，13，4： | 0 |
| 16 | First Beam Commissioning of SSC-Linac as an Injector of SSC显示文摘The construction of the SSC-Linac has made significant progress in 2019.The first beam commissioning of SSC-Linac as an injector of the Separated Sector Cyclotron(SSC)was performed succssfully with ^(40)Ar^(7+) beam and the particle energy of 5.98 MeV/u was obtained at the exit of SSC on December 17,2019. | Du Heng Yin Xuejun Yang Weiqing Li Zhongshan Kong Qiyu Li Xiaoni Yang Shengli Qian Cheng WangHaoning Cong Yan Jin Peng Zhang Ruifeng Han Xiaodong Fu Xin Wang Kai Jing Long Zhang Yong Li Lili Xie Wenjun Xu Xiaowei Wang Shaoming Chen Wenjun Liu Xiaojun Yue Min An Jingrui Zhang Xiang Yan Huaihai Feng Anhui Zhang Shuai Zhang Yongbo Sun Peng Zhu Tieming Sha Xiaoping Xu Jianye Sun Xiaolong Su Xuemin Li Anping Yan Tailai Meng Jun Zhang Wei Wu Junxia Yao Qinggao Yang Yaqing Xu Zhe Sun Liangting Gao Daqing Yuan Youjin Yang Jiancheng Xia Jiawen | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 17 | A multipath mitigation algorithm for GNSS signals based on the steepest descent approach显示文摘Multipath interference seriously degrades the performance of Global Navigation Satellite System(GNSS)positioning in an urban canyon.Most current multipath mitigation algorithms suffer from heavy computational load or need external assistance.We propose a multipath mitigation algorithm based on the steepest descent approach,which has the merits of less computational load and no need for external aid.A new ranging code tracking loop is designed based on the steepest descent method,which can save an early branch or a late branch compared with the narrow-spacing correlation method.The power of the Non-Line-of-Sight(NLOS)signal is weaker than that of the Line-of-Sight(LOS)signal when the LOS signal is not obstructed and with a relatively high Carrier Noise Ratio(CNR).The peak position in the X-axis of the ranging code autocorrelation function does not move with the NLOS interference.Meanwhile,the cost function is designed according to this phenomenon.The results demonstrate that the proposed algorithm outperforms the narrow-spacing correlation and the Multipath Estimated Delay Locked Loop(MEDLL)in terms of the code multipath mitigation and computation time.The Standard Deviation(STD)of the tracking error with the proposed algorithm is less than 0.016 chips.Moreover,the computation time of the proposed algorithm in a software defined receiver is shortened by 24.21%compared with the narrow-spacing correlation. | Wenqi Qiu Qinghua Zeng Rui Xu Jianye Liu Jinheng Shi Qian Meng | 2022 | Satellite Navigation2022，3，3： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员