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| 1 | Acupoint combinations used for treatment of Alzheimer's disease: A data mining analysis显示文摘OBJECTIVE: To identify the acupoint combinations used in the treatment of Alzheimer's disease(AD).METHODS: The clinical literature regarding acupuncture and moxibustion for AD was searched and collected from databases including Chinese Biomedical Medicine, China National Knowledge Infrastructure, Wanfang Database and PubMed. The database of acupuncture and moxibustion prescriptions for AD was established by using Excel software so as to conduct the descriptive analysis, association analysis on the data.RESULTS: Baihui(GV 20), Sishencong(EX-HN 1),Shenmen(HT 7), Zusanli(ST 36), Neiguan(PC 6),Fengchi(GB 20), Taixi(KI 3), Dazhui(GV 14), Shenshu(BL 23), Sanyinjiao(SP 6), Shenting(GV 24), Fenglong(ST 40), Xuanzhong(GB 39), Shuigou(GV 26)and Taichong(LR 3) were of higher frequency in the treatment of AD with acupnucture and moxibustion. Most acupoints were selected from the Governor Vessel. The commonly used acupoints were located on the head, face, neck and lower limbs. The combination of the local acupoints with the distal ones was predominated. The crossing points among the specific points presented the advantage in the treatment. The association analysis indicated that the correlation among Fengchi(GB 20)-Baihui(GV 20) was the strongest, followed by combinations of Dazhui(GV 14)-Baihui(GV 20), Shenshu(BL 23)-Baihui(GV 20) and Neiguan(PC 6)-Baihui(GV 20) and indicated the common rules of the clinical acupoint selection and combination for AD.CONCLUSION: Our findings provide a reference for acupoints selection and combination for AD in clinical acupuncture practice. | Yu Chaochao Wang Li Kong Lihong Shen Feng Ma Chaoyang Du Yanjun Zhou Hua | 2018 | Journal of Traditional Chinese Medicine2018，38，6： | 4 |
| 2 | Effects of inclusions on microstructure and properties of heat-affected-zone for low-carbon steels显示文摘The characteristics of inclusions in two types of low-carbon steels by different deoxidization methods have been investigated by using the welding thermal simulation,the optical microscopy and scanning electron microscopy.In addition,the effects of inclusions on microstructure and properties of heat-affected-zone were studied.The nucleation and growth of intragranular acicular ferrite was observed in situ by the laser scanning confocal microscopy.The distribution of Mn element near the inclusion was also analyzed by the auger electron spectroscopy.The results showed that the inclusions in Al killed steel are mainly aluminum oxides,manganese sulfide and titanium nitrides,and that the inclusions in Ti killed steel are mainly titanium oxide,manganese sulfide complex inclusion and single manganese sulfide.The auger electron spectroscopy showed that there is an Mn-depleted zone near the interface of TiO x /MnS complex inclusion in the size of 1-3 m.It could be the effective nucleus of intragranular acicular ferrite which could divide the prior austenite grains,inhibit the growth of low-temperature microstruc-ture,and refine the final microstructure,so as to improve the toughness of heat-affected-zone significantly. | ZHENG ChaoChao WANG XueMin LI ShuRui SHANG ChengJia HE XinLai | 2012 | Science China(Technological Sciences)2012，55，6： | 4 |
| 3 | Backscatter t echnologies and the future of Internet of Things:Challenges and opportunities显示文摘Energy source and circuit cost are two critical challenges for the future development of the Internet of Things(IoT).Backscatter communications offer a potential solution to conveniently obtain power and reduce cost for sensors in IoT,and researchers are paying close attention to the technology.Backscatter technology originated from the Second World War and has been widely applied in the logistics domain.Recently,both the academic and industrial worlds are proposing a series of new types of backscatter technologies for communications and IoT.In this paper,we review the history of both IoT and backscatter,describe the new types of backscatter,demonstrate their applications,and discuss the open challenges. | Chaochao Yao Yang Liu Xusheng Wei Gongpu Wang Feifei Gao | 2020 | Intelligent and Converged Networks2020，1，2： | 4 |
| 4 | Atomically precise metal-chalcogenide semiconductor molecular nanoclusters with high dispersibility:Designed synthesis and intracluster photocarrier dynamics显示文摘A comprehensive understanding of excited-state dynamics of semiconductor quantum dots or nanomaterials at the atomic or molecular level is of scientific importance.Pure inorganic(or non-covalently protected)seimiconductor molecular nanoclusters with atomically precise structure are contributive to establish accurate correlation of excited-state dynamics with their composition/structure,however,the related studies are almost blank because of unresolved solvent dispersion issue.Herein,we designedly created the largest discrete chalcogenide seimiconductor molecular nanoclusters(denoted P2-CuMSnS,M=In or/and Ga)with great dispersibility,and revealed an interesting intracluster“core–shell”charge transfer relaxation dynamics.A systematic red shift in absorption spectra with the gradual substitution of In by Ga was experimentally and computationally investigated,and femtosecond transient absorption measurements further manifested there were three ultrafast processes in excited-state dynamics of P2 nanoclusters with the corresponding amplitudes directed by composition variation.Current results hold the great promise of the solution-processible applications of semiconductor-NC-based quantum dots and facilitate the development of atomically precise nano-chemistry. | Jiaxu Zhang Chaochao Qin Yeshuang Zhong Xiang Wang Wei Wang Dandan Hu Xiaoshuang Liu Chaozhuang Xue Rui Zhou Lei Shen Yinglin Song Dingguo Xu Zhien Lin Jun Guo Haifeng Su Dong-Sheng Li Tao Wu | 2020 | Nano Research2020，13，10： | 2 |
| 5 | Isolation and characterization of Toxoplasma gondii strains from stray cats revealed a single genotype in Beijing, China显示文摘 | Weifeng Qian Hui Wang Chunlei Su Dan Shan Xia Cui Na Yang Chaochao Lv Qun Liu | 2012 | Veterinary Parasitology (-)2012，，3： | 2 |
| 6 | RGS16 regulated by let-7c-5p promotes glioma progression by activating PI3K-AKT pathway显示文摘Gliomas are the most common central nervous system tumours;they are highly aggressive and have a poor prognosis. RGS16 belongs to the regulator of G-protein signalling (RGS) protein family, which plays an important role in promoting various cancers, such as breast cancer, pancreatic cancer, and colorectal cancer. Moreover, previous studies confirmed that let-7c-5p, a well-known microRNA, can act as a tumour suppressor to regulate the progression of various tumours by inhibiting the expression of its target genes. However, whether RGS16 can promote the progression of glioma and whether it is regulated by miR let-7c-5p are still unknown. Here, we confirmed that RGS16 is upregulated in glioma tissues and that high expression of RGS16 is associated with poor survival. Ectopic deletion of RGS16 significantly suppressed glioma cell proliferation and migration both in vitro and in vivo. Moreover, RGS16 was validated as a direct target gene of miR let-7c-5p. The overexpression of miR let-7c-5p obviously downregulated the expression of RGS16, and knocking down miR let-7c-5p had the opposite effect. Thus, we suggest that the suppression of RGS16 by miR let-7c-5p can promote glioma progression and may serve as a potential prognostic biomarker and therapeutic target in glioma. | Chaochao Wang Hao Xue Rongrong Zhao Zhongzheng Sun Xiao Gao Yanhua Qi Huizhi Wang Jianye Xu Lin Deng Gang Li | 2023 | Frontiers of Medicine2023，17，1： | 2 |
| 7 | Tailoring spin mixtures by ion-enhanced Maxwell magnetic coupling in colortunable organic electroluminescent devices显示文摘In this work,we show that the spin dynamics of excitons can be dramatically altered by Maxwell magnetic field coupling,together with an ion-enhanced,low-internal-splitting-energy organic semiconducting emitter.By employing a unique,alternating current(AC)-driven organic electroluminescent(OEL)device architecture that optimizes this magnetic field coupling,almost complete control over the singlet-to-triplet ratio(from fluorescent to phosphorescent emission in a single device)is realized.We attribute this spin population control to magnetically sensitive polaron–spin pair intersystem crossings(ISCs)that can be directly manipulated through external driving conditions.As an illustration of the utility of this approach to spin-tailoring,we demonstrate a simple hybrid(double-layer)fluorescence–phosphorescence(F–P)device using a polyfluorene-based emitter with a strong external Zeeman effect and ion-induced long carrier diffusion.Remarkable control over de-excitation pathways is achieved by controlling the device-driving frequency,resulting in complete emission blue–red color tunability.Picosecond photoluminescence(PL)spectroscopy directly confirms that this color control derives from the magnetic manipulation of the singlet-totriplet ratios.These results may pave the way to far more exotic organic devices with magnetic-field-coupled organic systems that are poised to usher in an era of dynamic spintronics at room temperature. | Junwei Xu Yue Cui Gregory M.Smith Peiyun Li Chaochao Dun Linqi Shao Yang Guo Hongzhi Wang Yonghua Chen David L.Carroll | 2018 | Light(Science & Applications)2018，7，1： | 2 |
| 8 | The tomato 2-oxoglutarate-dependent dioxygenase gene SlF3HL is critical for chilling stress tolerance显示文摘Low temperature is a major stress that severely affects plant development,growth,distribution,and productivity.Here,we examined the function of a 2-oxoglutarate-dependent dioxygenase-encoding gene,SlF3HL,in chilling stress responses in tomato(Solanum lycopersicum cv.Alisa Craig[AC]).Knockdown(KD)of SlF3HL(through RNA interference)in tomato led to increased sensitivity to chilling stress as indicated by elevated levels of electrolyte leakage,malondialdehyde(MDA)and reactive oxygen species(ROS).In addition,the KD plants had decreased levels of proline and decreased activities of peroxisome and superoxide dismutase.The expression of four cold-responsive genes was substantially reduced in the KD plants.Furthermore,seedling growth was significantly greater in AC or SlF3HLoverexpression plants than in the KD plants under either normal growth conditions with methyl jasmonate(MeJA)or chilling stress conditions.SlF3HL appears to positively regulate JA accumulation and the expression of JA biosynthetic and signaling genes under chilling stress.Together,these results suggest that SlF3HL is a positive regulator of chilling stress tolerance and functions in the chilling stress tolerance pathways,possibly by regulating JA biosynthesis,JA signaling,and ROS levels. | Tixu Hu Yuqin Wang Qiqi Wang Ningning Dang Ling Wang Chaochao Liu Jianhua Zhu Xiangqiang Zhan | 2019 | Horticulture Research2019，6，1： | 1 |
| 9 | Crosstalk free integral imaging display with wide viewing angle using periodic black mask 显示文摘 | Luo Chenggao Ji Chaochao Wang Qionghua | 2012 | Journal of Display Technology2012，，： | 1 |
| 10 | Single-cell brain atlas of Parkinson's disease mouse model显示文摘Parkinson's disease(PD)is a neurodegenerative disease,leading to the impairment of movement execution.PD pathogenesis has been largely investigated,either limited to bulk transcriptomic levels or at certain cell types,which failed to capture the cellular heterogeneity and intrinsic interplays among distinct cell types.Here,we report the application of single-nucleus RNA-seq on midbrain,striatum,and cerebellum of theα-syn-A53 T mouse,a well-established PD mouse model,and matched controls,generating the first single cell transcriptomic atlas for the PD model mouse brain composed of 46,174 individual cells.Additionally,we comprehensively depicte the dysfunctions in PD pathology,covering the elevation of NF-k B activity,the alteration of ion channel components,the perturbation of protein homeostasis network,and the dysregulation of glutamatergic signaling.Notably,we identify a variety of cell types closely associated with PD risk genes.Taken together,our study provides valuable resources to systematically dissect the molecular mechanism of PD pathogenesis at the single-cell resolution,which facilitates the development of novel approaches for diagnosis and therapies against PD. | Jixing Zhong Gen Tang Jiacheng Zhu Weiying Wu Ge Li Xiumei Lin Langchao Liang Chaochao Chai Yuying Zeng Feiyue Wang Lihua Luo Jiankang Li Fang Chen Zhen Huang Xiuqing Zhang Yu Zhang Hongde Liu Xin Qiu Shengping Tang Dongsheng Chen | 2021 | Journal of Genetics and Genomics2021，48，4： | 1 |
| 11 | A cobalt(Ⅱ)porphyrin with a tethered imidazole for efficient oxygen reduction and evolution electrocatalysis显示文摘Electrocatalytic oxygen reduction and evolution reactions are involved in new energy conversion and storage technologies,such as various fuel cells and metal-air batteries and also water splitting devices[1,2].However,both reactions are very slow in kinetics,and thus catalysts are required[3,4]. | Xialiang Li Ping Li Jindou Yang Lisi Xie Ni Wang Haitao Lei Chaochao Zhang Wei Zhang Yong-Min Lee Weiqiang Zhang Shunichi Fukuzumi Wonwoo Nam Rui Cao | 2023 | Journal of Energy Chemistry2023，，1： | 1 |
| 12 | Extended finite element methods for optimal control problems governed by Poisson equation in non-convex domains显示文摘This paper analyzes two extended finite element methods(XFEMs)for linear quadratic optimal control problems governed by Poisson equation in non-convex domains.We follow the variational discretization concept to discretize the continuous problems,and apply an XFEM with a cut-off function and a classic XFEM with a fixed enrichment area to discretize the state and co-state equations.Optimal error estimates are derived for the state,co-state and control.Numerical results confirm our theoretical results. | Tao Wang Chaochao Yang Xiaoping Xie | 2021 | Science China Mathematics2021，64，8： | 1 |
| 13 | Bioactive constituents of animal-derived traditional Chinese medicinal materials for breast cancer:opportunities and challenges显示文摘Breast cancer is globally the most common invasive cancer in women and remains one of the leading causes of cancer-related deaths.Surgery,radiotherapy,chemotherapy,immunotherapy,and endocrine therapy are currently the main treatments for this cancer type.However,some breast cancer patients are prone to drug resistance related to chemotherapy or immunotherapy,resulting in limited treatment efficacy.Consequently,traditional Chinese medicinal materials(TCMMs)as natural products have become an attractive source of novel drugs.In this review,we summarized the current knowledge on the active components of animal-derived TCMMs,including Ophiocordyceps sinensis-derived cordycepin,the aqueous and ethanolic extracts of O.sinensis,norcantharidin(NCTD),Chansu,bee venom,deer antlers,Ostrea gigas,and scorpion venom,with reference to marked anti-breast cancer effects due to regulating cell cycle arrest,proliferation,apoptosis,metastasis,and drug resistance.In future studies,the underlying mechanisms for the antitumor effects of these components need to be further investigated by utilizing multi-omics technologies.Furthermore,large-scale clinical trials are necessary to validate the efficacy of bioactive constituents alone or in combination with chemotherapeutic drugs for breast cancer treatment. | Chaochao YU Yi LI Guopeng CHEN Chaoyan WU Xiuping WANG Yingwen ZHANG | 2022 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2022，23，7： | 1 |
| 14 | Cryptosporidium tyzzeri n. sp. (Apicomplexa: Cryptosporidiidae) in domestic mice ( Mus musculus )显示文摘 | Xupeng Ren Jinfeng Zhao Longxian Zhang Changshen Ning Fuchun Jian Rongjun Wang Chaochao Lv Qiang Wang Michael J. Arrowood Lihua Xiao | 2011 | Experimental Parasitology2011，，3： | 1 |
| 15 | Pixel extraction based integral imaging with controllable viewing direction显示文摘 | Ji Chaochao Deng Huan Wang Qionghua | 2012 | Journal of Optics2012，14，9： | 1 |
| 16 | Development of 107 SSRs markersfrom whole genome shotgun sequences of Chinese bayberry(Myrica rubra)and their application in seedling identification显示文摘 | JIA Huimin SHEN Yutong WANG Guoyun DONG Xiao DUFang LIANG Senmiao ZHOU Chaochao JIA Huijuan MAOWeihua GAO Zhongshan | 2014 | Jour-nal of Zhejiang University-Science Biomedicine&Biotechnolo-gy2014，15，11： | 1 |
| 17 | A carbon-neutrality-capactiy index for evaluating carbon sink contributions显示文摘The accurate determination of the carbon-neutrality capacity(CNC)of a region is crucial for developing policies related to emissions and climate change.However,a systematic diagnostic method for determining the CNC that considers the rock chemical weathering carbon sink(RCS)is lacking.Moreover,it is challenging but indispensable to establish a fast and practical index model to determine the CNC.Here,we selected Guizhou as the study area,used the methods for different types of carbon sinks,and constructed a CNC index(CNCI)model.We found that:(1)the carbonate rock chemical weathering carbon sink flux was 30.3 t CO_(2)km^(-2)yr^(-1).Guizhou accounted for 1.8%of the land area and contributed 5.4%of the carbonate chemical weathering carbon sink;(2)the silicate rock chemical weathering carbon sink and its flux were 1.44×10^(3)t CO_(2)and 2.43 t CO_(2)km^(-2)yr^(-1),respectively;(3)the vegetation-soil ecosystem carbon sink and its flux were 1.37×10^(8)t CO_(2)and 831.70 t CO_(2)km^(-2)yr^(-1),respectively;(4)the carbon emissions(CEs)were 280 Tg CO_(2),about 2.8%of the total for China;and(5)the total carbon sinks in Guizhou were 160 Tg CO_(2),with a CNCI of 57%,which is 4.8 times of China and 2.1 times of the world.In summary,we conducted a systematic diagnosis of the CNC considering the RCS and established a CNCI model.The results of this study have a strong implication and significance for national and global CNC determination and gap analysis. | Xiaoyong Bai Sirui Zhang Chaojun Li Lian Xiong Fengjiao Song Chaochao Du Minghui Li Qing Luo Yingying Xue Shijie Wang | 2023 | Environmental Science and Ecotechnology2023，，3： | 1 |
| 18 | Could the Recent Taal Volcano Eruption Trigger an El Ni?o and Lead to Eurasian Warming?显示文摘The Taal Volcano in Luzon is one of the most active and dangerous volcanoes of the Philippines.A recent eruption occurred on 12 January 2020(Fig.1a),and this volcano is still active with the occurrence of volcanic earthquakes.The eruption has become a deep concern worldwide,not only for its damage on local society,but also for potential hazardous consequences on the Earth’s climate and environment. | Fei LIU Chen XING Jinbao LI Bin WANG Jing CHAI Chaochao GAO Gang HUANG Jian LIU Deliang CHEN | 2020 | Advances in Atmospheric Sciences2020，37，7： | 1 |
| 19 | Highly Aligned Ultra-Thick Gel-Based Cathodes Unlocking Ultra-High Energy Density Batteries显示文摘Increasing electrode thickness can substantially enhance the specific energy of lithium-ion batteries;however,ionic transport,electronic conductivity,and ink rheology are current barriers to adoption.Here,a novel approach using a mixed xanthan gum and locust bean gum binder to construct ultrathick electrodes is proposed to address above issues.After combining aqueous binder with single-walled carbon nanotubes(SWCNT),active material(LiNi_(0.8)Co_(0.1)Mn_(0.1)O_(2)) and subsequent vacuum freeze-drying,highly aligned,and low-tortuosity structures with a porosity of ca.50%can be achieved with an average pore size of 10μm,whereby the gum binder-SWCNT-NMC811 forms vertical structures supported by tissue-like binder/SWCNT networks allowing for excellent electronic conducting phase percolation.As a result,ultra-thick electrodes with a mass loading of about 511 mg cm^(−2) and 99.5 wt%active materials have been demonstrated with a remarkable areal capacity of 79.3 mAh cm^(−2),which is the highest value reported so far.This represents a>25×improvement compared with conventional electrodes with an areal capacity of about 3 mAh cm^(−2).This route also can be expanded to other electrode materials,such as LiFePO_(4) and Li_(4)Ti_(5)O_(12),and thus opens the possibility for low-cost and sustainable ultra-thick electrodes with increased specific energy for future lithium-ion batteries. | Shichun Yang Chaochao Zhou Qiong Wang Binbin Chen Yan Zhao Bin Guo Zhengjie Zhang Xinlei Gao Ridwanur Chowdhury Huizhi Wang Chao Lai Nigel P.Brandon Billy Wu Xinhua Liu | 2022 | Energy & Environmental Materials2022，5，4： | 0 |
| 20 | The effect of glutathione on glucosinolate biosynthesis through the sulfur assimilation pathway in pakchoi associated with the growth conditions显示文摘Glucosinolates(GSLs) are a group of nitrogen-and sulfur-containing secondary metabolites, synthesized primarily in members of the Brassicaceae family, that play an important role in food flavor, plant antimicrobial activity, resistance to insect attack, stress tolerance, and human anti-cancer effects. As a sulfur-containing compound, glutathione has a strong connection with GSLs biosynthesis as a sulfur donor or redox system, and exists in reduced(glutathione;GSH) and oxidized(glutathione disulfide;GSSG) forms. However, the mechanism of GSH regulating GSLs biosynthesis remainds unclear. Hence, the exogenous therapy to pakchoi under normal growth condition and sulfur deficiency condition were conducted in this work to explore the relevant mechanism. The results showed that exogenous application of buthionine sulfoximine, an inhibitor of GSH synthesis, decreased the transcript levels of GSLs synthesis-related genes and transcription factors, as well as sulfur assimilation-related genes under the normal growth condition. Application of exogenous GSH inhibited the expression of GSLs synthesis-and sulfur assimilation-related genes under the normal condition, while the GSLs biosynthesis and the sulfur assimilation pathway were activated by exogenous application of GSH when the content of GSH in vivo of plants decreased owing to sulfur deficiency. Moreover,exogenous application of GSSG increased the transcript levels of GSLs synthesis-and sulfur assimilation-related genes under the normal growth condition and under sulfur deficiency. The present work provides new insights into the molecular mechanisms of GSLs biosynthesis underlying glutathione regulation. | Biao Zhu Zhile Liang Dan Wang Chaochao He Zhujun Zhu Jing Yang | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
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