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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | In situ AFM observation of BSA adsorption on HOPG with nanobubble显示文摘Nanobubbles have been proven existent at the liquid/solid interface, and become a focus of research on varied interfacial processes. In the present work, by observing in situ with atomic force microscope (AFM), we found that nanobubbles could influence the adsorption process of bovine serum albumin (BSA) on hydrophobic surface of highly ordered pyrolytic graphite (HOPG). BSA could adsorb evenly, and coexist with nanobubbles at water/HOPG interface. After removing nanobubbles by injecting ethanol, some hollows were found in the BSA layers at the same positions of nanobubbles existing previously. These hollows were about 8 nm in depth and dozens of nanometers in diameter. The correlation coefficient between the areas of nanobubbles and that of the corresponding hollows reached 0.88―0.94, which strongly supported the assumption that the hollows were indeed caused by the nanobubbles. Moreover, the BSA molecules formed rings around the nanobubbles, suggesting the preference of BSA adsorption onto the contact line at water/HOPG interface. | WU ZhiHua ZHANG XueHua ZHANG XiaoDong SUN JieLin DONG YaMing HU Jun | 2007 | Chinese Science Bulletin2007，52，14： | 3 |
| 3 | Application of image alignment and time averaging methods in AFM detection for single DNA molecules显示文摘Enhancement of the SNR (signal to noise ratio) in single-molecule imaging is significantly important for improving image resolu-tion and distinguishing the fine structures of single molecules at a higher precision level.Image processing techniques have dem-onstrated the remarkable capability to improve the SNR and the resolution level by breaking through some inherent limitations unresolved by instrument hardware optimization.In this paper, we focus on single-biomolecule imaging using atomic force mi-croscopy (AFM), a unique method in separated single-biomolecule imaging, and there was few suitable image processing tech-niques reported to increase the SNR of a single molecule’s AFM image.With the typical samples of separately dispersed DNA molecules, we replaced the classified averaging method, which is usually used when the molecules’ structure can be easily and repeatedly prepared, with the time averaging method to improve the SNR in a single molecule’s AFM imaging.Combining the time averaging technique with the image alignment method for the series of time-lapse AFM images of a single DNA molecule, we were able to improve the image’s SNR and recover some buried signals from the background noises.Furthermore, the fine structures of single molecules can potentially be further resolved if other image processing techniques are applied collaboratively with some newly developed imaging methods like Vibrating Mode Scanning Polarization Force Microscopy (VSPFM), and such combination will also be advantageous for the manipulation of single-biomolecules by AFM.In addition, the proposed algorithms for the estimations of drift, distortion and SNR are applicable for quantitative status characterization of AFM imaging. | WANG ChunMei SUN JieLin LONG Fei ZHAO Jun HU Jun | 2010 | Chinese Science Bulletin2010，55，16： | 3 |
| 4 | Prostate cancer risk-associated genetic markers and their potential clinical utility显示文摘前列腺癌症(PCa ) 是在在西方的发达国家的人之中的最普通的癌症之一,它的发生在世界的许多另外的部分更加增加了,包括中国。PCa 的病原学大部分是未知的,但是被认为是 multifactorial,在继承遗传起一个重要作用的地方。在这篇文章,我们简短首先从家庭聚集和基因危险性的研究考察结果到 PCa。我们然后,从连接的稀罕、高外显率的 PCa 危险性基因的翻新的胎面钥匙调查结果在 PCa 家庭学习。我们把这篇文章的重要部分奉献给在 PCa 情况和控制中从基因协会研究总结普通、低外显率的 PCa 联系风险的单个核苷酸的多型性(SNP ) 的发现,特别那些从染色体宽的协会研究(GWAS ) 。这篇文章的一个强壮的焦点是在这些含有的基因标记的潜在的临床的用途上考察文学。大多数这些出版研究用在为前列腺活体检视决定需要从多重联系风险的 SNP 和它的用途导出的一个基因分数描述了 PCa 风险评价。最后,我们评论基因分数的最新建议的概念;观点是为基因倾向把它当作一个标记,类似于家庭历史,而非一个诊断标记到从非癌症病人区别 PCa 病人。到日期的可得到的证据建议那个基因分数比家庭历史是一个目的和 PCa 的继承风险的更好的测量。这篇文章的另一个唯一的特征是在中国、日本的人口的 PCa 的基因协会研究的包括。 | Jianfeng Xu Jielin Sun S Lilly Zheng | 2013 | Asian Journal of Andrology2013，15，3： | 2 |
| 5 | Cleaning using nanobubbles: Defouling by electrochemical generation of bubbles显示文摘 | Zhihua Wu Hongbing Chen Yaming Dong Huiling Mao Jielin Sun Shenfu Chen Vincent S.J. Craig Jun Hu | 2008 | Journal of Colloid And Interface Science2008，，1： | 1 |
| 6 | Cleaning using nanobubbles: Defouling by electrochemical generation of bubbles显示文摘 | Zhihua Wu Hongbing Chen Yaming Dong Huiling Mao Jielin Sun Shenfu Chen Vincent S.J. Craig Jun Hu | 2008 | Journal of Colloid And Interface Science2008，，1： | 1 |
| 7 | Development of a low-noise cryogenic atomic force microscope for high resolution imaging of large biological complexes显示文摘有一会儿对能够决定大生物建筑群的结构的仪器的一个重要要求。当时原子力量显微镜学(RT-AFM ) 直接提供了的房间温度单个蛋白质的亚纳米分辨率图象,在更大的生物集会的图象的分辨率由于这些样品的固有的柔软部分至少是相当差的[1,2 ] 。我们以前为生物样品明确地开发了一台唯一的低温实验法的原子力量显微镜(cryo-AFM ) ,它能在象 77 K 一样低的温度想象[3 ] 。期望是所有生物分子将在这些低温实验法的温度变得难得多以便成像将是可能的为实质上所有生物样品不管他们的尺寸,异质的柔软,或范围。随后的直接大小证实了这些期望[3 ] ,并且这台仪器现在提供了大生物样品的详细图象,从 oligomeric 抗体到未经触动的房间膜,与能与 RT-AFM 被获得的超过那的分辨率[4-6 ] 。 | Ling Qin Jinjin Zhang Jielin Sun Daniel M. Czajkowsky Zhifeng Shao | 2016 | Acta Biochimica et Biophysica Sinica2016，48，9： | 0 |
| 8 | GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer显示文摘In the treatment of most malignancies,radiotherapy plays a significant role.However,the resistance of cancer cells to ionizing radiation(IR)is the main reason for the failure of radiotherapy,which causes tumor recurrence and metastasis.In this study,we confirmed that GPR162,an orphan receptor in the G-protein-coupled receptor family,acted as a novel radiotherapy sensitizer by interacting with the stimulator of interferon genes(STING),which targeted DNA damage responses,activated IRF3,accelerated the activation of type I interferon system,promoted the expression of chemokines including CXCL10 and CXCL4,and inhibited the occurrence and development of tumors.Interestingly,the activation of STING by overexpression of GPR162 was independent of the classical pathway of cGAS.STING inhibitors could resist the antitumor effect of overexpression of GPR162 in IR-induced mouse models.In addition,most solid tumors showed low expression of GPR162.And the higher expression of GPR162 indicated a better prognosis in patients with lung adenocarcinoma,liver cancer,breast cancer,etc.In summary,these results suggested that GPR162 may serve as a potential sensitizer of radiotherapy by promoting radiotherapy-induced STING-IFN production and increasing the expression of chemokines including CXCL10 and CXCL4 in DNA damage response,providing an alternative strategy for improving cancer radiotherapy. | Yao Long Jiaxing Guo Jielin Chen Jingyue Sun Haiyan Wang Xin Peng Zuli Wang WeiWei Lai Na Liu Long Shu Ling Chen Ying Shi Desheng Xiao Shuang Liu Yongguang Tao | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 0 |
| 9 | Function of XAGE-1b gene in metastasis process of adenoid cystic carcinoma显示文摘 | Xing Jun Qin Yang Jielin Zhang Chenping Guan Xiaofeng Sun Changfu | 2008 | 中国口腔颌面外科杂志2008，6，B05： | 0 |
| 10 | Expansion microscopy with carboxylic trifunctional linkers显示文摘Super-resolution optical microscopy has fundamentally transformed structural biology by enabling characterization of biological complexes with up to tenfold greater resolution than conventional microscopy[1].Among the number of different approaches with super-resolution capability,there is perhaps none more generally accessible to most research labs than expansion microscopy(ExM),where the enhanced resolution is owing to the physical separation of fluorescent signals(typically at least 4-fold)and imaging is performed using conventional optical or confocal microscopy[2]. | Xuecheng Chen Yaqian Li Jiabin Wang Jielin Sun Daniel M.Czajkowsky Zhifeng Shao | 2022 | Acta Biochimica et Biophysica Sinica2022，54，9： | 0 |
| 11 | Sequential One-Pot Three-Enzyme Synthesis of the Tetrasaccharide Repeating Unit of Group B Streptococcus Serotype Ⅷ Capsular Polysaccharide显示文摘The biochemical property and functional identification of three recombinant glycosyltransferases,includingβ-1,4-rhamnosyltransferase(Cps8R),β-1,4-galactosyltransferase(Cps8) and α-2,3-sialyltransferase(Cps8K)involved in the biosynthesis of the tetrasaccharide repeating unit of serotypeⅧcapsular polysaccharide(CPS)of Group B Streptococci(GBS),were systematically investigated.Subsequently,these recombinant enzymes were employed for one-pot three-enzyme efficient synthesis of the tetrasaccharide repeating unit of GBS serotypeⅧCPS using the chemically synthesized Glca-PP-(CH2)ir-OPh as the starting substrate in a satisfying yieldof 87%. | Min Liang Wei Gong Chongzhen Sun Jielin Zhao Hong Wang Zonggang Chen Min Xiao Guofeng Gu | 2022 | Chinese Journal of Chemistry2022，40，9： | 0 |
| 12 | Comparison of viral propagation and drug response among SARS-CoV-2 VOCs using replicons capable of recapitulating virion assembly and release显示文摘Several variants of concern(VOCs)have emerged since the WIV04 strain of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was first isolated in January 2020.Due to mutations in the spike(S)protein,these VOCs have evolved to enhance viral infectivity and immune evasion.However,whether mutations of the other viral proteins lead to altered viral propagation and drug resistance remains obscure.The replicon is a noninfectious viral surrogate capable of recapitulating certain steps of the viral life cycle.Although several SARS-CoV-2 replicons have been developed,none of them were derived from emerging VOCs and could only recapitulate viral genome replication and subgenomic RNA(sgRNA)transcription.In this study,SARS-CoV-2 replicons derived from the WIV04 strain and two VOCs(the Beta and Delta variants)were prepared by removing the S gene from their genomes,while other structural genes remained untouched.These replicons not only recapitulate viral genome replication and sgRNA transcription but also support the assembly and release of viral-like particles,as manifested by electron microscopic assays.Thus,the S-deletion replicon could recapitulate virtually all the post-entry steps of the viral life cycle and provides a versatile tool for measuring viral intracellular propagation and screening novel antiviral drugs,including inhibitors of virion assembly and release.Through the quantification of replicon RNA released into the supernatant,we demonstrate that viral intracellular propagation and drug response to remdesivir have not yet substantially changed during the evolution of SARS-CoV-2 from the WIV04 strain to the Beta and Delta VOCs. | Lingqian Tian Qiuhong Liu Rongjuan Pei Yingshan Chen Chonghui Xu Jielin Tang Hao Sun Kunpeng Liu Qi Yang Lei Yang Leshan Li Yongli Zhang Yuan Zhou Chao Shan Xue Hu Xinwen Chen Yun Wang | 2022 | Virologica Sinica2022，37，5： | 0 |
| 13 | 全基因组关联研究发现中国人群前列腺癌两个新易感位点9q31.2和19q13.4显示文摘0前言在全球范围内,前列腺癌的发病率和病死率存在着巨大差异。该病在西方发达国家发病率最高,在非裔美国人群病死率最高,而在亚洲人群中发病率及病死率均为全球最低,提示不同人种在前列腺癌的遗传方面存在异质性。在欧美和日本人群中,全基因组关联研究(GWAS)技术已经被用于检测前列腺癌的遗传易感性位点,但至今尚无关于GWAS检测中国人群前列腺癌易感位点的报道。 | Jianfeng Xu Zengnan Mo Dingwei Ye Meilin Wang Fang Liu Guangfu Jin Chuanliang Xu Xiang Wang Qiang Shao Zhiwen Chen Zhihua Tao Jun Qi Fangjian Zhou Zhong Wang Yaowen Fu Dalin He Qiang Wei Jianming Guo Denglong Wu Xin Gao Jianlin Yuan Gongxian Wang Yong Xu Guozeng Wang Haijun Yao Pei Dong Yang Jiao Mo Shen Jin Yang Jun Ou-Yang Haowen Jiang Yao Zhu Shancheng Ren Zhengdong Zhang Changjun Yin Xu Gao Bo Dai Zhibin Hu Yajun Yang Qijun Wu Hongyan Chen Peng Peng Ying Zheng Xiaodong Zheng Yongbing Xiang Jirong Long Jian Gong Rong Na Xiaoling Lin Hongjie Yu Sha Tao Junjie Feng Jishan Sun Wennuan Liu Ann Hsing Jianyu Rao Qiang Ding Fredirik Wiklund Henrik Gronberg Xiao-Ou Shu Wei Zheng Hongbing Shen Li Jin Rong Shi Daru Lu Xuejun Zhang Jielin Sun S Lilly Zheng Yinghao Sun | 2013 | 第二军医大学学报2013，34，4： | 0 |
| 14 | Author Correction:GPR162 activates STING dependent DNA damage pathway as a novel tumor suppressor and radiation sensitizer显示文摘Since the publication of this article,we noticed a minor mistake in the article that needs to be corrected.We have checked the original data;the correct data are provided in this Corrigendum as follows.The key findings of the article are not affected by these corrections. | Yao Long Jiaxing Guo Jielin Chen Jingyue Sun Haiyan Wang Xin Peng Zuli Wang WeiWei Lai Na Liu Long Shu Ling Chen Ying Shi Desheng Xiao Shuang Liu Yongguang Tao | 2023 | Signal Transduction and Targeted Therapy2023，8，7： | 0 |
| 15 | Transcriptome-wide alternative polyadenylation profiling reveals the herbal formula Yangyinjiedu-induced preferential poly(A)usage in lung adenocarcinoma cells显示文摘Alternative polyadenylation(APA)is widcsprcad across mammalian genome.Through generating messenger ribonucleic acid(mRNA)isoforms harboring 3'-untranslated regions(3'UTRs)with differ-ent lengths,APA contributes to the complexity of gene expression regulation and is involved in development and disease[1]. | Qiang Zhao Xinglong Shi Yucan Chen Ling Bi Jing Tian Ming Zhang Ling Xu Jielin Sun Xiaodong Zhao | 2020 | Acta Biochimica et Biophysica Sinica2020，52，10： | 0 |
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