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| 1 | Hypocoagulation induced by broadspectrum antibiotics in extensive burn patients显示文摘Background:Patients with extensive burns usually develop pro-coagulation soon after the injury if there is no sepsis occurred.We describe the case of an extensive burn adult suffering from hypocoagulation not related to sepsis,but secondary to antibiotic treatment.Case presentation:Here,we report a case of an adult male patient suffering from flame burns of 45%total body surface area(40%full thickness)combined with inhalation injury.Hypocoagulopathy with soaring prolonged activated partial thromboplastin time value occurred on third week post-burn while systemic infection had been under control by application of broad-spectrum antibiotics.Investigations showed that not the infection but vitamin K-related coagulation factor deficiency were responsible for unexpected bleeding.However,supplemental vitamin K was not the key as we expected,which prompted us trying to decode the underlying cause of coagulation disturbance in this patient and pick out the most effective treatment for live-saving.After the withdrawal of highly suspected broad-spectrum antibiotic,Meropenem^(■),disturbed vitamin K related coagulation factors gradually restored to their optimal levels so as to maintain normal coagulation status.Therefore,surgical procedures without further risk of bleeding could be carried out in time for wound recovery.The patient was discharged on post-burn day 67 and transferred to a secondary hospital for his rehabilitation.Conclusion:Hypocoagulopathy may be devoted to different reasons other than sepsis in extensive burns.Early recognition of the cause for coagulation disturbance is critical to make appropriate treatment and save patients’lives.This case illustrated the importance of unveiling the mist cause for coagulation disturbance occurred in extensive burn patient,which paved the way for optimal life-saving treatments.And we also recommend burn surgeons to be alerted to antibiotic-induced vitamin K deficiency-related coagulopathy among critical burn patients. | Jian Liu Yiqing Liu Shengjun Liu Qin Zhang Jiexin Zheng Yiwen Niu Xuefeng Wang | 2019 | Burns & Trauma2019，7，1： | 2 |
| 2 | Trace Amounts of Triple-Functional Additives Enable Reversible Aqueous Zinc-Ion Batteries from a Comprehensive Perspective显示文摘Although their cost-effectiveness and intrinsic safety,aqueous zinc-ion batteries suffer from notorious side reactions including hydrogen evolution reaction,Zn corrosion and passivation,and Zn dendrite formation on the anode.Despite numerous strategies to alleviate these side reactions have been demonstrated,they can only provide limited performance improvement from a single aspect.Herein,a triple-functional additive with trace amounts,ammonium hydroxide,was demonstrated to comprehensively protect zinc anodes.The results show that the shift of electrolyte pH from 4.1 to 5.2 lowers the HER potential and encourages the in situ formation of a uniform ZHS-based solid electrolyte interphase on Zn anodes.Moreover,cationic NH^(4+)can preferentially adsorb on the Zn anode surface to shield the“tip effect”and homogenize the electric field.Benefitting from this comprehensive protection,dendrite-free Zn deposition and highly reversible Zn plating/stripping behaviors were realized.Besides,improved electrochemical performances can also be achieved in Zn//MnO_(2)full cells by taking the advantages of this triple-functional additive.This work provides a new strategy for stabilizing Zn anodes from a comprehensive perspective. | Ruwei Chen Wei Zhang Quanbo Huang Chaohong Guan Wei Zong Yuhang Dai Zijuan Du Zhenyu Zhang Jianwei Li Fei Guo Xuan Gao Haobo Dong Jiexin Zhu Xiaohui Wang Guanjie He | 2023 | Nano-Micro Letters2023，15，6： | 2 |
| 3 | Fabrication of Tβ4-Exosome-releasing artificial stem cells for myocardial infarction therapy by improving coronary collateralization显示文摘Currently,stem cell transplantations in cardiac repair are limited owing to disadvantages,such as immunological rejection and poor cell viability.Although direct injection of exosomes can have a curative effect similar to that of stem cell transplantation,high clearance hinders its application in clinical practice.Previous reports suggested that induction of coronary collateralization can be a desired method of adjunctive therapy for someone who had missed the optimal operation time to attenuate myocardial ischemia.In this study,to mimic the paracrine and biological activity of stem cells,we developed artificial stem cells that can continuously release Tβ4-exosomes(Tβ4-ASCs)by encapsulating specific exosomes within microspheres using microfluidics technology.The results show that Tβ4-ASCs can greatly promote coronary collateralization in the periphery of the myocardial infarcted area,and its therapeutic effect is superior to that of directly injecting the exosomes.In addition,to better understand how it works,we demonstrated that the Tβ4-ASC-derived exosomes can enhance the angiogenic capacity of coronary endothelial cells(CAECs)via the miR-17-5p/PHD3/Hif-1αpathway.In brief,as artificial stem cells,Tβ4-ASCs can constantly release functional exosomes and stimulate the formation of collateral circulation after myocardial infarction,providing a feasible and alternative method for clinical revascularization. | Peier Chen Xiaodong Ning Weirun Li Yuxuan Pan Ling Wang Hekai Li Xianglin Fan Jiexin Zhang Tiantian Luo Yaobin Wu Caiwen Ou Minsheng Chen | 2022 | Bioactive Materials2022，7，8： | 2 |
| 4 | Poly (lactic acid)/chitosan hybrid nanoparticles for controlled release of anticancer drug显示文摘 | Shu Chen Wenlong Wang Liang Zhang Jiexin Wang Jian-Feng Chen Yuan Le | 2014 | Materials Science & Engineering C2014，，： | 1 |
| 5 | Nanonization of megestrol acetate by liquid precipitation显示文摘 | Zhang Zhibing Shen Zhigang Wang Jiexin Zhao Hong Chen Jianfeng | | 0，，18： | 1 |
| 6 | Micronization of atorvastatin calcium by antisolvent precipitation process显示文摘 | Zhang Haixia Wang Jiexin Zhang Zhibing Le Yuan Shen Zhigang Chen Jianfeng | | 0，，1： | 1 |
| 7 | SOC predic- tion based on evolutionary network 显示文摘 | Bo Cheng Yanlu Zhou Jiexin Zhang | 2009 | Proceedings of the IEEE International Conference on Automation and Logis- tics2009，，： | 1 |
| 8 | Corn ear test using SIFT-based panoramic photography and machine vision technology显示文摘Corn ear test is important to modern corn breeding.The test indexesmainly include lengths,radiuses,rows and numbers of corn ears and the kernels they bear,which can benefit the study on breeding new and fine corn varieties.These corn traits are often collected by traditional manual measurement,which is difficult to meet the needs of high throughput corn ear test.In this study,image sequences of corn ear samples were captured by building a panoramic photography collecting system.And then,to get the lengths and radiuses indexes,the corn area images were processed based on Lab color space and adaptive threshold segmentation.The sequence images were then matched and the panoramic image of a corn surface were extracted using Scale-invariant feature transform(SIFT).Finally,by using Exponential transformation(ETR)and Sobel-Hough algorithm,ears and rows indexes were acquired.Test results showed that the accuracy of the radiuses and lengths were 93.84%and 94.53%,respectively.Meanwhile,the accuracy of kernels and rows indexes were 98.12%and 96.14%,whichwere 4.03%and 7.25%higher than that of common mosaiced panoramic image.And the accuracy of kernel area and length-width ratio were 95.36%and 97.42%,respectively.All the results showed that the proposed method can be used for corn ear test effectively. | Xinyi Zhang Jiexin Liu Huaibo Song | 2020 | Artificial Intelligence in Agriculture2020，，1： | 1 |
| 9 | Irbesartan drug formulated as nanocomposite particles for the enhancement of the dissolution rate显示文摘Irbesartan(IBS),an angiotensin II receptor antagonist,is a poorly water-soluble drug.To enhance the dissolution rate,IBS nanocomposite particles were produced via an anti-solvent precipitation combined with a spray drying process.Four pharmaceutically acceptable excipients,including three different polymers and one charged surfactant,were evaluated as stabilizers to control the particle size and to prevent the agglomeration of particles.The experiment results indicated that polyvinylpyrrolidone(PVP)combined with sodium dodecyl sulfate(SDS)significantly decreased the particle size and enhanced the stability of drug nanoparticles.As a result,we finally obtained stable IBS nanoparticles with an average size of approximately 55 nm.In the dissolution test,the IBS nanocomposite particles showed a significantly enhanced dissolution rate and 100%of the drug dissolved within 20 min.In contrast,the physical mixture with the same recipe as the IBS nanocomposite particles and the raw IBS reached only 8%and 40%of drug dissolved in 20 min,respectively,and both of them did not dissolve completely,even after 120 min. | Zhiliang Zhang Yuan Le Jiexin wang Hong Zhao Jianfeng Chen | 2012 | Particuology2012，10，4： | 1 |
| 10 | Hypnotic effect of jujubosides from Semen Ziziphi Spinosae显示文摘 | CAO Jiexin ZHANG Qingying CUI Suying | 2010 | Journal of Ethnopharmacology2010，130，1： | 1 |
| 11 | The Effect of Grinding Machine Stiffness on Surface Integrity of Silicon Nitride显示文摘 | Yang Fulun Zhang Bi Wang Jiexin | 2001 | Journal of Manufacturing Science and Engineering2001，123，4： | 1 |
| 12 | The effect of machine stiffness on grinding of silicon nitride显示文摘 | Wang Jiexin Yang Fulun | 1998 | International Journal of Machine Tool and Manufacture1998，39，1： | 1 |
| 13 | Ni-MH batteries state-of-charge prediction based on immune evolutionary network显示文摘 | Bo Cheng Yanlu Zhou Jiexin Zhang | | 0，，12： | 1 |
| 14 | ERP correlates of com- positionality in Chinese idiom comprehension显示文摘 | Zhang Hui Yang Yiming Gu Jiexin & Ji Feng | 2013 | Journal of Neurolin- guistics2013，，1： | 1 |
| 15 | pH-Responsive Polycarbonate Copolymer-based Nanoparticles for Targeted Anticancer Drug Delivery显示文摘 | LI Yunxia DU Wenjuan FU Zhiguang WANG Huanhuan WANG Jiexin LE Yuan ZHANG Jianjun WEN Ning | 2018 | Chemical Research in Chinese Universities2018，34，6： | 0 |
| 16 | A variable structure passivity control method for elastic joint robots based on cascaded high-order state estimation显示文摘Passivity-based controllers are widely used to facilitate physical interaction between humans and elastic joint robots,as they enhance the stability of the interaction system.However,the joint position tracking performance can be limited by the structures of these controllers when the system is faced with uncertainties and rough high-order system state measurements(such as joint accelerations and jerks).This study presents a variable structure passivity(VSP)control method for joint position tracking of elastic joint robots,which combines the advantages of passive control and variable structure control.This method ensures the tracking error converges in a finite time,even when the system faces uncertainties.The method also preserves the passivity of the system.Moreover,a cascaded observer,called CHOSSO,is also proposed to accurately estimate high-order system states,relying only on position and velocity signals.This observer allows independent implementation of disturbance compensation in the acceleration and jerk estimation channels.In particular,the observer has an enhanced ability to handle fast time-varying disturbances in physical human-robot interaction.The effectiveness of the proposed method is verified through simulations and experiments on a lower limb rehabilitation robot equipped with elastic joints. | ZHANG JieXin NIE PingYun ZHANG Bo | 2024 | Science China(Technological Sciences)2024，67，2： | 0 |
| 17 | N6-methyladenosine facilitates mitochondrial fusion of colorectal cancer cells via induction of GSH synthesis and stabilization of OPA1 mRNA显示文摘Mitochondria undergo fission and fusion that are critical for cell survival and cancer development,while the regulatory factors for mitochondrial dynamics remain elusive.Herein we found that RNA m^(6)A accelerated mitochondria fusion of colorectal cancer(CRC)cells.Metabolomics analysis and function studies indicated that m^(6)A triggered the generation of glutathione(GSH)via the upregulation of RRM2B-a p53-inducible ribonucleotide reductase subunit with anti-reactive oxygen species potential.This in turn resulted in the mitochondria fusion of CRC cells.Mechanistically,m^(6)A methylation of A1240 at 3'UTR of RRM2B increased its mRNA stability via binding with IGF2BP2.Similarly,m^(6)A methylation of A2212 at the coding sequence(CDS)of OPA1-an essential GTPase protein for mitochondrial inner membrane fusion-also increased mRNA stability and triggered mitochondria fusion.Targeting m^(6)A through the methyltransferase inhibitor STM2457 or the dm^(6)ACRISPR system significantly suppressed mitochondria fusion.In vivo and clinical data confirmed the positive roles of the m^(6)A/mitochondrial dynamics in tumor growth and CRC progression.Collectively,m^(6)A promoted mitochondria fusion via induction of GSH synthesis and OPA1 expression,which facilitated cancer cell growth and CRC development. | Jiawang Zhou Haisheng Zhang Ke Zhong Lijun Tao Yu Lin Guoyou Xie Yonghuang Tan You Wu Yunqing Lu Zhuojia Chen Jiexin Li Xin Deng Qin Peng Zigang Li Hongsheng Wang | 2024 | National Science Review2024，11，3： | 0 |
| 18 | Interface-induced polymerization strategy for constructing titanium dioxide embedded carbon porous framework with enhanced chemical immobilization towards lithium polysulfides显示文摘The shuttle effect induced by soluble lithium polysulfides(LiPSs)is known as one of the crucial issues that limit the practical applications of lithium-sulfur(Li-S)batteries.Herein,a titanium dioxide nanoparticle embedded in nitrogen-doped porous carbon nanofiber(TiO_(2)@NCNF)composite is constructed via an interface-induced polymerization strategy to serve as an ideal sulfur host.Under the protection of the nanofiber walls,the uniformly dispersed TiO_(2) nanocrystalline can act as capturing centers to constantly immobilize LiPSs towards durable sulfur chemistry.Besides,the mesoporous microstructure in the fibrous framework endows the TiO_(2)@NCNF host with strong physical reservation for sulfur and LiPSs,sufficient pathways for electron/ion transfer,and excellent endurance for volume change.As expected,the sulfur-loaded TiO_(2)@NCNF composite electrode presents a fabulous rate performance and long cycle lifespan(capacity fading rate of 0.062%per cycle over 500 cycles)at 2.0 C.Furthermore,the assembled Li-S batteries harvest superb areal capacity and cycling stability even under high sulfur loading and lean electrolyte conditions. | Yue Ouyang Xiaoxiao Li Jiexin Zhu Wei Zong Yuhang Dai Xuan Gao Wei Zhang Shengyuan Yang Roohollah Bagherzadeh Feili Lai Yue-E Miao Tianxi Liu | 2024 | Nano Research2024，17，3： | 0 |
| 19 | Activating Inert Sites in Cobalt Silicate Hydroxides for Oxygen Evolution through Atomically Doping显示文摘Metal silicate hydroxides have been recognized as efficient oxygen evolution reaction(OER)electrocatalysts,yet tailoring of their intrinsic activity remains confused.Herein,Fe had been incorporated into cobalt silicate hydroxide nanosheets and the resulted material achieves a competitive OER catalytic activity.It is found that the doping state obviously affects the electrical transport property.Specifically,highly dispersed Fe atoms(low-concentration Fe doping)trigger slight electron transfer to Co atoms while serried Fe(highconcentration Fe doping)attract vast electrons.By introducing 6 at.%Fe doping,partial relatively inert Co sites are activated by atomically dispersed Fe,bearing an optimal metal 3d electronic occupation and adsorption capacity to oxygen intermediate.The introduced Co-O-Fe unit trigger the p-donation effect and decrease the number of electrons in p*-antibonding orbitals,which enhance the Fe-O covalency and the structural stability.As a result,the sample delivers a low overpotential of 293 mV to achieve a current density of 10 mA cm^(-2).This work clarifies the superiority of atomically dispersed doping state,which is of fundamental interest to the design of doped catalyst. | Jiexin Zhu Lixue Xia Wenxuan Yang Ruohan Yu Wei Zhang Wen Luo Yuhang Dai Wei Wei Liang Zhou Yan Zhao Liqiang Mai | 2022 | Energy & Environmental Materials2022，5，2： | 0 |
| 20 | Amorphous NaVOPO_(4)as a High-Rate and Ultrastable Cathode Material for Sodium-Ion Batteries显示文摘The low cost and profusion of sodium resources make sodium-ion batteries(SIBs)a potential alternative to lithium-ion batteries for grid-scale energy storage applications.However,the use of conventional cathode materials for Na-ion intercalation/deintercalation cannot satisfy the requirements of high-powered and long lifespan performance due to multiphase transition and lattice confinement. | Yongjin Fang Jiexin Zhang Faping Zhong Xiangming Feng Weihua Chen Xinping Ai Hanxi Yang Yuliang Cao | 2021 | CCS Chemistry2021，3，10： | 0 |
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