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| 1 | Typical basin-fill sequences and basin migration in Yanshan, North China ——Response to Mesozoic tectonic transition显示文摘Basin-fill sequences of Mesozoic typical basins in the Yanshan area, North China may be divided into four phases, reflecting lithosphere tectonic evolution from flexure (T3), flexure with weak rifting (J1+2), tectonic transition (J3), and rifting (K). Except the first phase, the other three phases all start with lava and volcaniclastic rocks, and end with thick coarse clastic rocks and/or conglomerates, showing cyclic basin development rather than simple cyclic rift mechanism and disciplinary basin-stress change from extension to compression in each phase. Prototype basin analysis, based on basin-fill sequences, paleocurrent distribution and depositional systems, shows that single basin-strike and structural-line direction controlling basin development had evidently changed from east-west to northeast in Late Jurassic in the Yanshan area, although basin group still occurred in east-west zonal distribution. Till Early Cretaceous, main structural-line strike controlling basins just turned to northeast by north in the studied area. | LI Zhong, LIU Shaofeng, ZHANG Jinfang & WANG Qingchen1. Institute of Geology and Geophysics, Chinese Academy of Sciences, Beijing 100029, China 2. China University of Geosciences, Beijing 100083, ChinaCorrespondence should be addressed to Li Zhong (email: lizhongd@mail.igcas.ac.cn) | 2004 | Science China Earth Sciences2004，47，2： | 15 |
| 2 | A Novel Single-Nucleotide Mutation in a CLAVATA3 Gene Homolog Controls a Multilocular Silique Trait in Brassica rapa L.显示文摘 | Chuchuan Fan, Yudi Wu, Qingyong Yang, Yang Yang, Qingwei Meng, Keqiao Zhang, Jinguo Li, Jinfang Wang Yongming Zhou | 2014 | Molecular Plant2014，7，12： | 12 |
| 3 | NDRG4 prevents cerebral ischemia/reperfusion injury by inhibiting neuronal apoptosis显示文摘Cerebral ischemia is a major cause of mortality and long-term morbidity worldwide.NDRG4 has been shown to protect against cerebral ischemia,although the underlying mechanisms remain largely unclear.Here we found that NDRG4 expression was decreased in the brain tissues of ischemia/reperfusion(IR)rats,indicating increased apoptosis rates among cerebral cells.NDRG4 restoration via an adenovirus significantly attenuated cerebral infarct sizes and impairments in IR rats.Furthermore,adenovirus-mediated NDRG4 inhibited cell apoptosis in the brains of IR rats and regulated the expression of Bcl-2,Bax,caspase-3,and c-Fos.Moreover,we found that NDRG4 increased expression of BDNF,which is strongly related to cerebral ischemia and cellular apoptosis.Altogether,our findings demonstrate that NDRG4 protects cerebral IR injury by inhibiting cell apoptosis and regulates cerebral cell apoptosis by increasing BDNF expression.These results suggest that NDRG4 may be a therapeutic target for IR treatment. | Lan Wen Lei Liu Linyan Tong Jinfang Li Keming Zhang Qinbin Zhang Changqing Li | 2019 | Genes & Diseases2019，6，4： | 6 |
| 4 | On the Influences of Urbanization on the Extreme Rainfall over Zhengzhou on 20 July 2021: A Convection-Permitting Ensemble Modeling Study显示文摘This study investigates the influences of urban land cover on the extreme rainfall event over the Zhengzhou city in central China on 20 July 2021 using the Weather Research and Forecasting model at a convection-permitting scale[1-km resolution in the innermost domain(d3)].Two ensembles of simulation(CTRL,NURB),each consisting of 11 members with a multi-layer urban canopy model and various combinations of physics schemes,were conducted using different land cover scenarios:(i)the real urban land cover,(ii)all cities in d3 being replaced with natural land cover.The results suggest that CTRL reasonably reproduces the spatiotemporal evolution of rainstorms and the 24-h rainfall accumulation over the key region,although the maximum hourly rainfall is underestimated and displaced to the west or southwest by most members.The ensemble mean 24-h rainfall accumulation over the key region of heavy rainfall is reduced by 13%,and the maximum hourly rainfall simulated by each member is reduced by 15–70 mm in CTRL relative to NURB.The reduction in the simulated rainfall by urbanization is closely associated with numerous cities/towns to the south,southeast,and east of Zhengzhou.Their heating effects jointly lead to formation of anomalous upward motions in and above the planetary boundary layer(PBL),which exaggerates the PBL drying effect due to reduced evapotranspiration and also enhances the wind stilling effect due to increased surface friction in urban areas.As a result,the lateral inflows of moisture and high-θe(equivalent potential temperature)air from south and east to Zhengzhou are reduced. | Yali LUO Jiahua ZHANG Miao YU Xudong LIANG Rudi XIA Yanyu GAO Xiaoyu GAO Jinfang YIN | 2023 | Advances in Atmospheric Sciences2023，40，3： | 4 |
| 5 | New insights into molecules and pathways of cancer metabolism and therapeutic implications显示文摘Cancer cells are abnormal cells that can reproduce and regenerate rapidly.They are characterized by unlimited proliferation,transformation and migration,and can destroy normal cells.To meet the needs for cell proliferation and migration,tumor cells acquire molecular materials and energy through unusual metabolic pathways as their metabolism is more vigorous than that of normal cells.Multiple carcinogenic signaling pathways eventually converge to regulate three major metabolic pathways in tumor cells,including glucose,lipid,and amino acid metabolism.The distinct metabolic signatures of cancer cells reflect that metabolic changes are indispensable for the genesis and development of tumor cells.In this review,we report the unique metabolic alterations in tumor cells which occur through various signaling axes,and present various modalities available for cancer diagnosis and clinical therapy.We further provide suggestions for the development of anti-tumor therapeutic drugs. | Zhenye Tang Zhenhua Xu Xiao Zhu Jinfang Zhang | 2021 | Cancer Communications2021，41，1： | 4 |
| 6 | Prevalence of polycystic ovary syndrome in women in China: a large community-based study显示文摘 | Rong Li Qiufang Zhang Dongzi Yang Shangwei Li Shulan Lu Xiaoke Wu Zhaolian Wei Xueru Song Xiuxia Wang Shuxin Fu Jinfang Lin Yimin Zhu Yong Jiang Huai L. Feng Jie Qiao | 2013 | Human Reproduction2013，，9： | 4 |
| 7 | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies显示文摘Neutralizing monoclonal antibodies(nAbs)to severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)represent promising candidates for clinical intervention against coronavirus disease 2019(COVID-19).We isolated a large number of nAbs from SARS-CoV-2-infected individuals capable of disrupting proper interaction between the receptor binding domain(RBD)of the viral spike(S)protein and the receptor angiotensin converting enzyme 2(ACE2).However,the structural basis for their potent neutralizing activity remains unclear.Here,we report cryo-EM structures of the ten most potent nAbs in their native full-length IgG-form or in both IgG-form and Fab-form bound to the trimeric S protein of SARS-CoV-2.The bivalent binding of the full-length IgG is found to associate with more RBDs in the“up”conformation than the monovalent binding of Fab,perhaps contributing to the enhanced neutralizing activity of IgG and triggering more shedding of the S1 subunit from the S protein.Comparison of a large number of nAbs identified common and unique structural features associated with their potent neutralizing activities.This work provides a structural basis for further understanding the mechanism of nAbs,especially through revealing the bivalent binding and its correlation with more potent neutralization and the shedding of S1 subunit. | Renhong Yan Ruoke Wang Bin Ju Jinfang Yu Yuanyuan Zhang Nan Liu Jia Wang Qi Zhang Peng Chen Bing Zhou Yaning Li Yaping Shen Shuyuan Zhang Long Tian Yingying Guo Lu Xia Xinyue Zhong Lin Cheng Xiangyang Ge Juanjuan Zhao Hong-Wei Wang Xinquan Wang Zheng Zhang Linqi Zhang Qiang Zhou | 2021 | Cell Research2021，31，5： | 4 |
| 8 | Design and Experimental Evaluation of PID Controller for Digital Electro-Pneumatic Cabin Pressure Control System显示文摘The performance of the designed digital electro-pneumatic cabin pressure control system for the cabin pressure schedule of transport aircraft is investigated.For the purpose of this study,an experimental setup consisting of a simulated hermetic cabin and altitude simulation chamber is configured for cabin pressure control system operation.A series of experimental tests are executed to evaluate the performance of the cabin pressure control system.The parameters of the PID controller are optimized.In the optimization process,the variation regularity of the rate of cabin pressure change under various conditions is considered.An approach to prioritize the control of the rate of change of cabin pressure based on the flight status model is proposed and verified experimentally.The experimental results indicate that the proposed approach can be adopted for the designed digital electro-pneumatic cabin pressure control system to obtain a better cabin pressure schedule and rate of cabin pressure change. | Nie Jinfang Pan Quan Shen Hao Song Zhitao Zhang Dalin | 2016 | Transactions of Nanjing University of Aeronautics and Astronautics2016，33，5： | 3 |
| 9 | A Comparison of Grading Index and Relative Feed Value in Forage Quality Evaluation显示文摘 | Zhang Jikun Chen Kaiwen Xie Jinfang De Xunlu Hu Ming | 2008 | Feed & Livestock2008，1，2： | 3 |
| 10 | A systematic review on food lead concentration and dietary lead exposure in China显示文摘 | Jin Yingliang Liu Pei Wu Yongning Min Jie Wang Cannan Sun Jinfang Zhang Yafei | 2014 | Chinese Medical Journal2014，，15： | 3 |
| 11 | Ginseng saponin Rbl enhances hematopoietic function and dendritic cells differentiation显示文摘 | Li Zhang Hui Feng Yibo He Jinfang Zhao Yimin Chen Yonglin Liu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 3 |
| 12 | The chromosome-level genome of dragon fruit reveals whole-genome duplication and chromosomal co-localization of betacyanin biosynthetic genes显示文摘Dragon fruits are tropical fruits economically important for agricultural industries.As members of the family of Cactaceae,they have evolved to adapt to the arid environment.Here we report the draft genome of Hylocereus undatus,commercially known as the white-fleshed dragon fruit.The chromosomal level genome assembly contains 11 longest scaffolds corresponding to the 11 chromosomes of H.undatus.Genome annotation of H.undatus found~29,000 protein-coding genes,similar to Carnegiea gigantea(saguaro).Whole-genome duplication(WGD)analysis revealed a WGD event in the last common ancestor of Cactaceae followed by extensive genome rearrangements.The divergence time between H.undatus and C.gigantea was estimated to be 9.18 MYA.Functional enrichment analysis of orthologous gene clusters(OGCs)in six Cactaceae plants found significantly enriched OGCs in drought resistance.Fruit flavor-related functions were overrepresented in OGCs that are significantly expanded in H.undatus.The H.undatus draft genome also enabled the discovery of carbohydrate and plant cell wall-related functional enrichment in dragon fruits treated with trypsin for a longer storage time.Lastly,genes of the betacyanin(a red-violet pigment and antioxidant with a very high concentration in dragon fruits)biosynthetic pathway were found to be co-localized on a 12 Mb region of one chromosome.The consequence may be a higher efficiency of betacyanin biosynthesis,which will need experimental validation in the future.The H.undatus draft genome will be a great resource to study various cactus plants. | Jinfang Zheng Lyndel W.Meinhardt Ricardo Goenaga Dapeng Zhang Yanbin Yin | 2021 | Horticulture Research2021，8，1： | 3 |
| 13 | Self-Stabilized Precipitation Polymerization and Its Application显示文摘An efective,value-added use of the large amounts of olefnic compounds produced in the processing of petroleum,aside from ethylene and propylene,has been a long outstanding challenge.Here,we developed a novel heterogeneous polymerization method,beyond emulsion/dispersion/suspension,termed self-stabilized precipitation(2SP)polymerization,which involves the nucleation and growth of nanoparticles(NPs)of a well-defned size without the use of any stabilizers and multifunctional monomers(crosslinker).Tis technique leads to two revolutionary advances:(1)the generation of functional copolymer particles from single olefnic monomer or complex olefnic mixtures(including C4/C5/C9 fractions)in large quantities,which open a new way to transform huge amount of unused olefnic compounds in C4/C5/C9 fractions into valuable copolymers,and(2)the resultant polymeric NPs possess a self-limiting size and narrow size distribution,therefore being one of the most simple,efcient,and green strategies to produce uniform,size-tunable,and functional polymeric nanoparticles.More importantly,the separation of the NPs from the reaction medium is simple and the supernatant liquid can be reused;hence this new synthetic strategy has great potential for industrial production. | Zhenjie Liu Dong Chen Jinfang Zhang Haodong Liao Yanzhao Chen Yingfa Sun Jianyuan Deng Wantai Yang | 2018 | Research2018，，1： | 3 |
| 14 | Characterization of major water-soluble inorganic ions in size-fractionated particulate matters in Shanghai campus ambient air显示文摘 | Guangli Xiu Danian Zhang Jizhang Chen Xuejuan Huang Zhixiang Chen Honglian Guo Jinfang Pan | 2003 | Atmospheric Environment2003，，2： | 2 |
| 15 | Correction: The NAC transcription factor ClNAC68 positively regulates sugar content and seed development in watermelon by repressing ClINV and ClGH3.6显示文摘In this article 1,author name Yanping Wang was incorrectly tagged as corresponding author.Prof.Wang should be the co-first author,instead of the corresponding author.The original article has been corrected. | Jinfang Wang Yanping Wang Jie Zhang Yi Ren Maoying Li Shaowei Tian Yongtao Yu Yi Zuo Guoyi Gong Haiying Zhang Shaogui Guo Yong Xu | 2021 | Horticulture Research2021，8，1： | 2 |
| 16 | Exploration and Research of Deep Crustal Structures in the Zhangzhou Basin and Its Vicinity显示文摘The Zhangzhou basin is located at the middle section of the southeast coast seismic zone of the mainland of China. Using high-resolution refraction and wide-angle reflection/refraction seismic profiling of Zhangzhou basin and its vicinity, we have obtained the crustal geometric structure and velocity structure as well as the geometric configuration and structural relationship between the deep and shallow fractures.The results show that the crust in the region is divided into the upper crust and lower crust. The thickness of the upper crust is 16.5km~18.8km, and that of the lower crust is 12.0km~13.0km. The upper crust is further divided into an upper and lower section. In the lower section of the upper crust, there is a low-velocity layer with a velocity of about 6.00km/s; the depth of the top surface of the low-velocity layer is about 12.0km, and the thickness is about 5.0km. The lower crust is also divided into an upper and lower section. The depth of Moho is 29.0km~31.8km. There are 6 normal faults in the shallow crust in this region, and most of them extend downwards to a depth of less than 4km, the maximum depth is about 5km.Below the shallow normal faults, there is a conjectural high-dip angle deep fault zone. The fault zone extends downwards till the Moho and upwards into the low-velocity layer in lower section of the upper crust. The deep and shallow faults are not tectonically connected. The combination character of deep and shallow structures in the Zhangzhou basin indicates that the Jiulongjiang fault zone is a deep fault zone with distinct characteristics and a complex deep and shallow structure background. The acquisition of deep seismic exploration results obviously enhanced the reliability of explanation of deep-structural data and the exploration precision of the region. The combination of deep and shallow structures resulted in uniform explanation results. The delamination of the crust and the characteristic of the structures are more precise and explicit. We discovered for the first time the combination characteristics of extensional structures and listric faults in the upper crust. This is not only helpful to the integrative judgment of earthquake risk in Zhangzhou and its vicinity, but also of importance for deepening the knowledge of deep dynamic processes in the southeast coast seismic zone. | Zhu Jinfang Fang Shengming Zhang Xiankang Qu Guosheng Huang Zonglin Zhang Chengke Zhao Jinren | 2006 | Earthquake Research in China2006，20，4： | 2 |
| 17 | Low phosphorus promotes NSP1–NSP2 heterodimerization to enhance strigolactone biosynthesis and regulate shoot and root architecture in rice显示文摘Phosphorus is an essential macronutrient for plant development and metabolism,and plants have evolved ingenious mechanisms to overcome phosphate(Pi)starvation.However,the molecular mechanisms underlying the regulation of shoot and root architecture by low phosphorus conditions and the coordinated utilization of Pi and nitrogen remain largely unclear.Here,we show that Nodulation Signaling Pathway 1(NSP1)and NSP2 regulate rice tiller number by promoting the biosynthesis of strigolactones(SLs),a class of phytohormones with fundamental effects on plant architecture and environmental responses.We found that NSP1 and NSP2 are induced by Oryza sativa PHOSPHATE STARVATION RESPONSE2(OsPHR2)in response to low-Pi stress and form a complex to directly bind the promoters of SL biosynthesis genes,thus markedly increasing SL biosynthesis in rice.Interestingly,the NSP1/2–SL signaling module represses the expression of CROWN ROOTLESS 1(CRL1),a newly identified early SL-responsive gene in roots,to restrain lateral root density under Pi deficiency.We also demonstrated that GR24^(4DO) treatment under normal conditions inhibits the expression of OsNRTs and OsAMTs to suppress nitrogen absorption but enhances the expression of OsPTs to promote Pi absorption,thus facilitating the balance between nitrogen and phosphorus uptake in rice.Importantly,we found that NSP1p:NSP1 and NSP2p:NSP2 transgenic plants show improved agronomic traits and grain yield under low-and medium-phosphorus conditions.Taken together,these results revealed a novel regulatory mechanism of SL biosynthesis and signaling in response to Pi starvation,providing genetic resources for improving plant architecture and nutrient-use efficiency in low-Pi environments. | Kun Yuan Hao Zhang Chaoji Yu Nan Luo Jijun Yan Shuang Zheng Qingliang Hu Dahan Zhang Liquan Kou Xiangbing Meng Yanhui Jing Mingjiang Chen Xinwei Ban Zongyun Yan Zefu Lu Jian Wu Yu Zhao Yan Liang Yonghong Wang Guosheng Xiong Jinfang Chu Ertao Wang Jiayang Li Bing Wang | 2023 | Molecular Plant2023，16，11： | 2 |
| 18 | Cdhl regulates craniofacial development via APC- dependent ubiquitination and activation of Goosecoid显示文摘 | Rui Shao Jia Liu Guang Yan Jinfang Zhang Yujiao Han Jianfeng Guo Zhan Xu Zhu Yuan Jiankang Liu Marcos Malumbres Lixin Wan Wenyi Wei Weiguo Zou | 2016 | Cell Research2016，26，6： | 2 |
| 19 | Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘Whether glucose is predomi nantly metabolized via oxidative phosphorylati on or glycolysis differs between quiesce nt versus proliferating cells,iincluding tumor cells.However,how glucose metabolism is coordinated with cell cycle in mammalian cells remains elusive.Here,we report that mammalian cells predominantly utilize the tricarboxylic acid(TCA)cycle in G1 phase,but prefer glycolysis in S phase.Mechanistically,coupling cell cycle with metabolism is largely achieved by timely destruction of IDH1/2,key TCA cycle enzymes,in a Skp2-dependent manner.As such,depleting SKP2 abolishes cell cycle-dependent fluctuation of IDH1 protein abundance,leading to reduced glycolysis in S phase.Furthermore,elevated Skp2 abundance in prostate cancer cells destabilizes IDH1 to favor glycolysis and subsequent tumorigenesis.Therefore,our study reveals a mechanistic link between two cancer hallmarks,aberrant cell cycle and addiction to glycolysis,and provides the underlying mechanism for the coupling of metabolic fluctuation with periodic cell cycle in mammalian cells. | Jing Liu Yunhua Peng Le Shi Lixin Wan Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wang Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfic John M.Asara William G.Kaelin Jr. Jjankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 2 |
| 20 | A flextensional transducer and its algorithmic method of resonant frequency显示文摘A flextensional transducer with an Omega shape and its algorithmic method of the resonant frequency and the shape functions are suggested.The Omega transducer is separated into four parts treated respectively as a thin shell of revolution and the theories of thin shells of revolution and piezoelectricity are used to obtain the energy functional of each part so that the sum of the energy functionals of the four parts is the energy functional of the whole Omega transducer.By substituting the shape functions with undetermined coefficients and the geometrical boundary conditions into the energy functional of the Omega transducer,the resonant frequency of the Omega transducer is firstly determined with the Rayleigh-Ritz method.With the gotten resonant frequency,the constant coefficients of the shape functions are following solved through the Rayleigh-Ritz partial differential equations and the geometrical boundary condition equations.The solving method of the resonant frequency and the shape functions is also extended to the cymbal transducer.Such an analytical method is verified to be feasible by the results of the finite element analysis and experiments.The research indicates that(1) The radial vibration of the piezoelectric ceramic is in phase with the longitudinal vibration of the top of metal cap,and it cut down the reversed phase component in the sound field. The Omega transducer can be a low frequency transducer.(2) The determination method of the resonant frequency and the shape functions give a solution to the optimum designs of the Omega transducer and the cymbal transducer.(3) The determination method of the resonant frequency and the shape functions can also be used in other flextensional transducers or other structures which are composed of thin shells of revolution,so it is universal. | WANG Yuhong WANG Deshi CHENG Jinfang ZHANG Kai | 2013 | Chinese Journal of Acoustics2013，32，2： | 2 |
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