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| 1 | Effects of yeast and yeast cell wall polysaccharides supplementation on beef cattle growth performance, rumen microbial populations and lipopolysaccharides production显示文摘This experiment was conducted to investigate the effects of live yeast and yeast cell wall polysaccharides on growth performance,rumen function and plasma lipopolysaccharides(LPS) content and immunity parameters of beef cattle.Forty Qinchuan cattle were randomly assigned to one of four treatments with 10 replicates in each treatment.The dietary treatments were: control diet(CTR),CTR supplemented with 1 g live yeast(2×10^10 live cell g^-1 per cattle per day(YST1),CTR supplemented with 2 g live yeast per cattle per day(YST2) and CTR supplemented with 20 g of yeast cell wall polysaccharides(30.0%≤β-glucan≤35.0%,and 28.0%≤mannanoligosaccharide≤32.0%) per cattle per day(YCW).The average daily gain was higher(P=0.023) and feed conversion ratio was lower(P=0.042) for the YST2 than the CTR.The digestibility of neutral detergent fiber(P=0.039) and acid detergent fiber(P=0.016) were higher in yeast supplemented groups.The acetic acid:propionic acid of the YST2 was lower compared with the CTR(P=0.033).Plasma LPS(P=0.032),acute phase protein haptoglobin(P=0.033),plasma amyloid A(P=0.015) and histamine(P=0.038) were lower in the YST2 compared with the CTR.The copies of fibrolytic microbial populations such as Fibrobacter succinogenes S85,Ruminococcus albus 7 and Ruminococcus flavefaciens FD-1 of the YST2 were higher(P<0.001),while the copies of typical lactate producing bacteria Streptococcus bovis JB1 was lower(P<0.001) compared with the CTR.Little differences were observed between the CTR,YST1 and YCW in growth performance,ruminal fermentation characteristics,microbial populations,immunity indices and total tract nutrient digestibility.It is concluded that the YST2 could promote fibrolytic microbial populations,decrease starch-utilizing bacteria,reduce LPS production in the rumen and LPS absorption into plasma and decrease inflammatory parameters,which can lead to an improvement in growth performance in beef cattle. | PENG Quan-hui CHENG Long KANG Kun Tian Gang Mohammad Al-Mamun XUE Bai WANG Li-zhi ZOU Hua-wei Mathew Gitau Gicheha WANG Zhi-sheng | 2020 | Journal of Integrative Agriculture2020，19，3： | 9 |
| 2 | Application of video-assisted thoracic surgery in the standard operation for thoracic tumors显示文摘Objective: To evaluate the short-term outcomes of video-assisted thoracic surgery (VATS) for thoracic tumors. Methods: The data of 1,790 consecutive patients were retrospectively reviewed. These patients underwent VATS pulmonary resections, VATS esophagectomies, and VATS resections of mediastinal tumors or biopsies at the Cancer Institute & Hospital, Chinese Academy of Medical Sciences between January 2009 and January 2012. Results: There were 33 patients converted to open thoracotomy (OT, 1.84%). The overall morbidity and mortality rate was 2.79% (50/1790) and 0.28% (5/1790), respectively. The overall hospitalization and chest tube duration were shorter in the VATS lobectomy group (n=949) than in the open thoracotomy (OT) lobectomy group (n=753). There were no significant differences in morbidity rate, mortality rate and operation time between the two groups. In the esophageal cancer patients, no significant difference was found in the number of nodal dissection, chest tube duration, morbidity rate, mortality rate, and hospital length of stay between the VATS esophagectomy group (n=81) and open esophagectomy group (n=81). However, the operation time was longer in the VATS esophagectomy group. In the thymoma patients, there was no significant difference in the chest tube duration, morbidity rate, mortality rate, and hospital length of stay between the VATS thymectomy group (n=41) and open thymectomy group (n=41). However, the operation time was longer in the VATS group. The median tumor size in the VATS thymectomy group was comparable with that in the OT group. Conclusions: In early-stage (I/II) non-small cell lung cancer patients who underwent lobectomies, VATS is comparable with the OT approach with similar short-term outcomes. In patients with resectable esophageal cancer, VATS esophagectomy is comparable with OT esophagectomy with similar morbidity and mortality. VATS thymectomy for Masaoka stage I and II thymoma is feasible and safe, and tumor size is not contraindicated. Longer follow-ups are needed to determine the oncologic equivalency of VATS lobectomy, esophagectomy, and thymectomy for thymoma vs. OT. | Ju-Wei Mu Gui-Yu Chen Ke-Lin Sun Da-Wei Wang Bai-Hua Zhang Ning Li Fang Lv You-Sheng Mao Qi Xue Shu-Geng Gao Jun Zhao Da-Li Wang Zhi-Shan Li Wen-Dong Lei Yu-Shun Gao Liangze Zhang Jin-Feng Huang Kang Shao Kai Su Kun Yang Liang Zhao Fei-Yue Feng Yong-Gang Wang Jian Li Jie He | 2013 | Cancer Biology & Medicine2013，10，1： | 8 |
| 3 | Self-powered photoelectrochemical biosensing platform based on Au NPs@ZnO nanorods array显示文摘Photoanodes,它在 photoelectrochemical (PEC ) 被使用切开的水,被显示了在一个 PEC biosensing 平台的构造适用。这被用一个适当测试分子的氧化代替水氧化认识到。这里,我们表明了采用由为谷胱甘肽(GSH ) 的自我动力的 PEC bioanalysis 与 plasmonic 金牌 nanoparticles (Au NPs@ZnO NR ) 装饰在的锌氧化物 nanorods 数组组成的 photoanodes 的可行性缓冲磷酸盐盐(PBS ) 在 0 V 对 Ag/AgCl 的一个应用偏爱潜力。因为 Au/ZnO 接口的介绍,这 heterostructure 展出了提高的 PEC 性质。在可见轻照明下面,从在 Au NP 表面的表面电浆子回声(SPR ) 的热电子被注入邻近的 ZnO 并且随后开车到光阴极。在下面紫外(紫外) 轻照明,在 ZnO 的 photogenerated 电子趋于由于逐步的精力乐队结构和在 ZnO/ 电解质接口弯曲的向上的精力乐队转到做氟的符号的听氧化物。这些结果显示 plasmonic 金属 / 半导体 heterostructure photoanodes 为自我动力的 PEC bioanalysis 应用和另外的光电的烽火的扩大的地有大潜力。 | Zhuo Kang Xiaoqin Yan Yunfei Wang Yanguang Zhao Zhiming Bai Yichong Liu Kun Zhao Shiyao Cao Yue Zhang | 2016 | Nano Research2016，9，2： | 8 |
| 4 | Gold nanoparticle/ZnO nanorod hybrids for enhanced reactive oxygen species generation and photodynamic therapy显示文摘金 nanoparticle (Au NP )@ ZnO nanorod (NR )(Au@ZnO ) 有各种各样的 ZnO 的混血儿: Au 臼齿的比率被开发在光力学的治疗(太平洋夏季时间) 提高反应的氧种类(ROS ) 的产生应用程序。介绍在 Au NP 和 ZnO NR 之间的一个金属 / 半导体 heterostructure 接口调制了电子转移在下面紫外(紫外) 照耀,它戏剧性地在 ZnO 压制了电子洞再结合并且同时在 Au NP 表面与高精力增加了激动的电子的数量。因此, nanohybrid 的 ROS 收益更加独自太古的 Au NP 或 ZnO NR 在那些上被改进并且表明了 1 + 1 > 2 效果。这改进随混血儿的 Au 的比例的增加被加强。结果证明有 ZnO 的 Au@ZnO nanohybrids : 因为他们有在 Au 和 ZnO 之间的最大的接口区域, 20:1 的 Au 比率产生了最高的 ROS 收益,它接着在太平洋夏季时间期间为 HeLa 和 C2C12 房间导致了最低房间生存能力。而且, ROS 产生和房间破坏断然与 nanohybrid 剂量被相关。Au@ZnO 混血儿(20:1, 100 g/mL ) 导致了为 2 min 象 28% 一样在紫外暴露以后低的 HeLa 房间生存能力,它显示了它的有希望的潜力改进太平洋夏季时间的治疗学的功效。 | Zhuo Kang Xiaoqin Yan Lanqing Zhao Qingliang Liao Kun Zhao Hongwu Du Xiaohui Zhang Xueji Zhang Yue Zhang | 2015 | Nano Research2015，8，6： | 7 |
| 5 | Active dry yeast supplementation improves the growth performance,rumen fermentation, and immune response of weaned beef calves显示文摘The objective of this experiment was to investigate the potential benefits of active dry yeast(ADY)on the growth performance,rumen fermentation,nutrient digestibility,and serum parameters of weaned beef calves.Thirty Simmental crossbred male calves(body weight=86.47±4.41 kg and 70±4 d of age)were randomly divided into 2 groups:control(CON)(fed basal ration)and ADY(fed basal ration and 5 g/d ADY per calf).The dietary concentrate-to-roughage ratio was 35:65.All the calves were regularly provided rations 3 times a day at 07:00,13:00,and 19:00 and had free access to wate r.The experiment lasted for 60 d.The average daily gain of ADY group was higher(P=0.007)than that of the CON group,and the ratio of feed intake to average daily gain in the ADY group was reduced(P=0.022)as compared to the CON group.The concentration of ruminal ammonia-N was higher(P=0.023)in the CON group than that in the ADY group,but an opposite trend of microbial protein was found between the 2 groups.Also,the ruminal concentrations of propionate and butyrate were higher(P<0.05)in the ADY group than those in the CON group.Calves fed ADY exhibited higher(P<0.05)crude protein and neutral detergent fiber digestibility.Supplementation of ADY increased(P<0.05)the contents of glucose,glutathione peroxidase,superoxide dismutase,immunoglobulin A,immunoglobulin M,and interleukin 10 in the serum of calves,but an opposite trend was observed in malondialdehyde,interleukin 1 beta,and tumor necrosis factor alpha contents between the 2 groups.In conclusion,dietary supplementation with ADY could improve the growth performance,rumen fermentation,nutrient digestibility,antioxidant ability,and immune response of weaned beef calves. | Jian Ma Cheng Wang Zhisheng Wang Guang Cao Rui Hu Xueying Wang Huawei Zou Kun Kang Quanhui Peng Bai Xue Lizhi Wang Yueming Zhu Xiaopeng Zhu | 2021 | Animal Nutrition2021，，4： | 7 |
| 6 | The RING E3 ligase CLG1 targets GS3 for degradation via the endosome pathway to determine grain size in rice显示文摘G-protein signaling and ubiquitin-dependent degradation are both involved in grain development in rice,but how these pathways are coordinated in regulating this process is unknown.Here,we show that Chang Li Geng 1(CLG1),which encodes an E3 ligase,regulates grain size by targeting the Gγprotein GS3,a negative regulator of grain length,for degradation.Overexpression of CLG1 led to increased grain length,while overexpression of mutated CLG1 with changes in three conserved amino acids decreased grain length.We found that CLG1 physically interacts with and ubiquitinats GS3which is subsequently degraded through the endosome degradation pathway,leading to increased grain size.Furthermore,we identified a critical SNP in the exon 3 of CLG1 that is significantly associated with grain size variation in a core collection of cultivated rice.This SNP results in an amino acid substitution from Arg to Ser at position 163 of CLG1 that enhances the E3 ligase activity of CLG1 and thus increases rice grain size.Both the expression level of CLG1 and the SNP CLG1163S may be useful variations for manipulating grain size in rice. | Wensi Yang Kun Wu Bo Wang Huanhuan Liu Siyi Guo Xiaoyu Guo Wei Luo Shengyuan Sun Yidan Ouyang Xiangdong Fu Kang Chong Qifa Zhang Yunyuan Xu | 2021 | Molecular Plant2021，14，10： | 6 |
| 7 | Application of 3D printing technology in bone tissue engineering显示文摘 | Kang Ji Yanen Wang Qinghua Wei Kun Zhang Anguo Jiang Yiwen Rao Xianxuan Cai | 2018 | Bio-Design and Manufacturing2018，1，3： | 5 |
| 8 | Good laboratory practices guarantee biosafety in the Sierra Leone-China friendship biosafety laboratory显示文摘Background:The outbreak of Ebola virus disease(EVD)in West Africa between 2014 and 2015 was the largest EDV epidemic since the identification of Ebola virus(EBOV)in 1976,and the countries most strongly affected were Sierra Leone,Guinea,and Liberia.Findings:The Sierra Leone-China Friendship Biological Safety Laboratory(SLE-CHN Biosafety Lab),a fixed Biosafety Level 3 laboratory in the capital city of Sierra Leone,was established by the Chinese government and has been active in EBOV detection since 11 March 2015.Complete management and program documents were created for the SLE-CHN Biosafety Lab,and it was divided into four zones(the green,yellow,brown,and red zones)based on the risk assessment.Different types of safe and appropriate personnel protection equipment(PPE)are used in different zones of the laboratory,and it fully meets the Biosafety Level 3 laboratory standards of the World Health Organization.Conclusion:Good preparedness,comprehensive risk assessment and operation documents,appropriate PPE,effective monitoring and intensive training,together with well-designed and reasonable laboratory sectioning are essential for guaranteeing biosafety. | Qin Wang Wei-Min Zhou Yong Zhang Huan-Yu Wang Hai-Jun Du Kai Nie Jing-Dong Song Kang Xiao Wen-Wen Lei Jian-Qiang Guo He-Jiang Wei Kun Cai Yan-Hai Wang Jiang Wu Gerard Kamara Idrissa Kamara Qiang Wei Mi-Fang Liang Gui-Zhen Wu Xiao-Ping Dong | 2016 | Infectious Diseases of Poverty2016，5，1： | 5 |
| 9 | CMOS-compatible high-index doped silica waveguide with an embedded silicon-nanocrystal strip for all-optical analog-to-digital conversion显示文摘Passive all-optical signal processors that overcome the electronic bottleneck can potentially be the enabling components for the next-generation high-speed and lower power consumption systems. Here, we propose and experimentally demonstrate a CMOS-compatible waveguide and its application to the all-optical analog-to-digital converter(ADC) under the nonlinear spectral splitting and filtering scheme. As the key component of the proposed ADC, a 50 cm long high-index doped silica glass spiral waveguide is composed of a thin silicon-nanocrystal(Si-nc) layer embedded in the core center for enhanced nonlinearity. The device simultaneously possesses low loss(0.16 dB/cm at 1550 nm), large nonlinearity(305 W^-1∕km at 1550 nm), and negligible nonlinear absorption.A 2-bit ADC basic unit is achieved when pumped by the proposed waveguide structure at the telecom band and without any additional amplification. Simulation results that are consistent with the experimental ones are also demonstrated, which further confirm the feasibility of the proposed scheme for larger quantization resolution.This demonstrated approach enables a fully monolithic solution for all-optical ADC in the future, which can digitize broadband optical signals directly at low power consumption. This has great potential on the applications of high-speed optical communications, networks, and signal processing systems. | YUHUA LI KUN ZHU ZHE KANG WAI LOK HO ROY DAVIDSON CHAO LU BRENT ELITTLE SAI TAK CHU | 2019 | Photonics Research2019，7，10： | 5 |
| 10 | Treatment for gastric ‘indefinite for neoplasm/dysplasia' lesions based on predictive factors显示文摘BACKGROUND Gastric ‘indefinite for neoplasm/dysplasia'(IFND) is a borderline lesion that is difficult to diagnose as either regenerative or neoplastic. There is a need for guidance in the identification of a subset of patients, who have an IFND lesion with a higher risk of malignant potential, to enable risk stratification and optimal management.AIM To determine the clinical and pathologic factors for the accurate diagnosis of gastric IFND lesions.METHODS In total, 461 gastric lesions diagnosed via biopsy as IFND lesions were retrospectively evaluated. Endoscopic resection(n = 134), surgery(n = 22), and follow-up endoscopic biopsy(n = 305) were performed to confirm the diagnosis.The time interval from initial biopsy to cancer diagnosis was measured, and diagnostic delays were categorized as > 2 wk, > 2 mo, > 6 mo, and > 1 year. The IFND lesions presenting as regenerating atypia(60%) or atypical epithelia(40%)at initial biopsy were adenocarcinomas in 22.6%, adenomas in 8.9%, and gastritis in 68.5% of the cases.RESULTS Four clinical factors [age ≥ 60 years(2.445, 95%CI: 1.305-4.580, P = 0.005),endoscopic size ≥ 10 mm(3.519, 95%CI: 1.891-6.548, P < 0.001), single lesion(5.702, 95%CI: 2.212-14.696, P < 0.001), and spontaneous bleeding(4.056, 95%CI:1.792-9.180, P = 0.001)], and two pathologic factors [atypical epithelium(25.575,95%CI: 11.537-56.695, P < 0.001], and repeated IFND diagnosis [6.022, 95%CI:1.822-19.909, P = 0.003)] were independent risk factors for gastric cancer. With two or more clinical factors, the sensitivity and specificity for carcinoma were91.3% and 54.9%, respectively. Ten undifferentiated carcinomas were initially diagnosed as IFND. In the subgroup analysis, fold change(5.594, 95%CI: 1.458-21.462, P = 0.012) predicted undifferentiated or invasive carcinoma in the submucosal layers or deeper. Diagnostic delays shorter than 1 year were not associated with worse prognoses. Extremely well-differentiated adenocarcinomas accounted for half of the repeated IFND cases and resulted in low diagnostic accuracy even on retrospective blinded review.CONCLUSION More than two clinical and pathologic factors each had significant cut-off values for gastric carcinoma diagnosis; in such cases, endoscopic resection should be considered. | Mi Jung Kwon Ho Suk Kang Hyeon Tae Kim Jin Woo Choo Bo Hyun Lee Sung Eun Hong Kun Ha Park Dong Min Jung Hyun Lim Jae Seung Soh Sung Hoon Moon Jong Hyeok Kim Hye-Rim Park Soo Kee Min Jin won Seo Ji-Young Choe | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 11 | Transcriptome analysis of salt-responsive genes and SSR marker exploration in Carex rigescens using RNA-seq显示文摘Carex rigescens(Franch.) V.Krecz is a wild turfgrass perennial species in the Carex genus that is widely distributed in salinised areas of northern China.To investigate genome-wide salt-response gene networks in C.rigescens,transcriptome analysis using high-throughput RNA sequencing on C.rigescens exposed to a 0.4% salt treatment(Cr_Salt) was compared to a non-salt control(Cr_Ctrl).In total,57 742 546 and 47 063 488 clean reads were obtained from the Cr_Ctrl and Cr_Salt treatments,respectively.Additionally,21 954 unigenes were found and annotated using multiple databases.Among these unigenes,34 were found to respond to salt stress at a statistically significant level with 6 genes up-regulated and 28 downregulated.Specifically,genes encoding an EF-hand domain,ZFP and AP2 were responsive to salt stress,highlighting their roles in future research regarding salt tolerance in C.rigescens and other plants.According to our quantitative RT-PCR results,the expression pattern of all detected differentially expressed genes were consistent with the RNA-seq results.Furthermore,we identified 11 643 simple sequence repeats(SSRs) from the unigenes.A total of 144 amplified successfully in the C.rigescens cultivar Lüping 1,and 69 of them reflected polymorphisms between the two genotypes tested.This is the first genome-wide transcriptome study of C.rigescens in both salt-responsive gene investigation and SSR marker exploration.Our results provide further insights into genome annotation,novel gene discovery,molecular breeding and comparative genomics in C.rigescens and related grass species. | LI Ming-na LONG Rui-cai FENG Zi-rong LIU Feng-qi SUN Yan ZHANG Kun KANG Jun-mei WANG Zhen CAO Shi-hao | 2018 | Journal of Integrative Agriculture2018，17，1： | 4 |
| 12 | Improvement on a Biometric Based User Authentication Scheme in Wireless Sensor Networks Using Smart Cards显示文摘With the development of the Internet of Things(IoT)technique,sensitive information collected by sensors may be leaked.In recent years,many authentication schemes have been proposed.Banerjee et al proposed a biometric based user authentication scheme in wireless sensor networks using smart cards in 2019.But we found that Banerjee et al's authentication scheme is vulnerable to impersonation attacks.In order to overcome the weaknesses of Banerjee et al's scheme,we propose a new authentication scheme.In our proposed scheme,we only use the exclusive-or operation and one-way Hash function for the efficiency,which can reduce the computation burden for the IoT devices.In the authentication and session key agreement phase,the secret registration parameter is not used for the authentication,and the session key is given for the all entities.In the Devol-Yao threat model,the security analysis demonstrates that our proposed authentication scheme can resist well-known attacks. | DU Jianqi KANG Baoyuan HAN Yanbao QIAN Kun | 2020 | Wuhan University Journal of Natural Sciences2020，25，2： | 3 |
| 13 | Extension Protocol for the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC)Study:2021 update显示文摘Background Malnutrition is common in patients with cancer,and this adversely affects the survival and quality of life of patients.Chinese Society for Nutritional Oncology issued a multi-center,large-scale,long-term follow-up prospective study,the Investigation on Nutrition Status and Clinical Outcome of Patients with Common Cancers in China(INSCOC study)since 2013.This is an extension to the previous 2013-2020 study protocol.This study still sought to:①address the prognostic impact of nutritional factors and quality of life on cancer patient survival;②describe the overall and cancer-specific incidence and/or distribution of malnutrition and different measurements of patient quality of life.Methods and study design This is an observational,multi-centered,hospital-based prospective cohort study.Data collection will be performed at baseline(within 48 hours after patient admission),during the hospital stay and 30 days after hospital admission.Follow-up will be conducted for 1-20 years after enrollment.The primary outcome will be the all-cause mortality/overall survival,and secondary outcomes will be the length of hospital stay and costs of hospitalization.Study factors will include demographic characteristics,tumor characteristics,information about chronic diseases,hematological measurements(e.g.,red blood cell count,total lymphocyte counts,hemoglobin,albumin,prealbumin,creatinine,C-reactive protein,IL-6),anthropometric measurements(e.g.,height,weight,arm circumference,arm muscle circumference,triceps skinfold thickness,and waist circumference),body composition parameters,PG-SGA scores,quality of life(as indicated by the QLQ-C30 questionnaire),muscle mass(as indicated by the calf circumference),muscle strength(as indicated by the handgrip strength),muscle function(as indicated by the six-meter walking speed test)and physical status assessments(as indicated by the Karnofsky Performance Status scores).This clinical study protocol was approved by local Ethics Committees of all the participating hospitals.Written informed consent is required for each subject included.Discussion This multi-center,large-scale,long-term follow up prospective study will help improve the diagnosis of malnutrition in cancer patients and identify the risk factors associated with adverse clinical outcomes.The anticipated results of this study will highlight the need for a truly scientific appraisal of nutrition therapy in Chinese oncology populations,and finally help treat the potentially reversible elements of malnutrition in cancer patients to improve their clinical outcomes in the future. | Hong Xia Xu Chun Hua Song Liang Yu Yin Chang Wang Zhen Ming Fu Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Zhi Kang Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Xiang Hua Wu Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Ya Yin Yu Quan Jun Lyu Hong Qiu Ming Liu Wei Li Han Ping Shi The Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2022 | Journal of Nutritional Oncology2022，7，2： | 3 |
| 14 | Mid-infrared photon counting and resolving via efficient frequency upconversion显示文摘Optical detectors with single-photon sensitivity and large dynamic range would facilitate a variety of applications.Specifically,the capability of extending operation wavelengths into the mid-infrared region is highly attractive.Here we implement a mid-infrared frequency upconversion detector for counting and resolving photons at 3μm.Thanks to the spectrotemporal engineering of the involved optical fields,the mid-infrared photons could be spectrally translated into the visible band with a conversion efficiency of 80%.In combination with a silicon avalanche photodiode,we obtained unprecedented performance with a high overall detection efficiency of 37%and a low noise equivalent power of 1.8×10^(-17) W∕Hz1∕2.Furthermore,photon-number-resolving detection at mid-infrared wavelengths was demonstrated,for the first time to our knowledge,with a multipixel photon counter.The implemented upconversion detector exhibited a maximal resolving photon number up to 9 with a noise probability per pulse of 0.14%at the peak detection efficiency.The achieved photon counting and resolving performance might open up new possibilities in trace molecule spectroscopy,sensitive biochemical sensing,and free-space communications,among others. | KUN HUANG YINQI WANG JIANAN FANG WEIYAN KANG YING SUN YAN LIANG QIANG HAO MING YAN HEPING ZENG | 2021 | Photonics Research2021，9，2： | 2 |
| 15 | Prognostic value of the D‐dimer test in oesophageal cancer during the perioperative period显示文摘 | Dongmei Diao Kun Zhu Zhe Wang Yao Cheng Kang Li Leilei Pei Chengxue Dang | 2013 | J. Surg. Oncol2013，，1： | 2 |
| 16 | Effect of Ti/V ratio on thermodynamics and kinetics of MC in γ/α matrices of Ti-V microalloyed steels显示文摘Through the solubility product theory of the ternary secondary phase,classical nucleation theory,and Ostwald ripening theory,a model was established to describe the thermodynamics and kinetics of(Ti,V)C precipitates in austenite/ferrite(y/α)matrices.The model was used to calculate the volume fraction,precipitation-temperature-time(PTT)curve,and nucleation rate-temperature(NrT)curve of MC(M=Ti,V)precipitates in γ/α matrices in Ti-V microalloyed steels with various Ti/V ratios,which is verified by hardness tester,transmission electron microscopy and energy-dispersive X-ray spectroscopy.The calculations indicate that,by decreasing Ti/V ratio from Ti4V0 steel to Ti0V4 steel,the complete-dissolution temperature decreases monotonically from 1226 to 830℃,and the equilibrium volume fraction of MC pre-cipitated from austenite decreases from 0.333%to 0.091%at 900℃.Moreover,the maximum nucleation temperature of MC precipitated from α matrix decreases from 748 to 605℃and the fastest precipitation temperature decreases from 844 to 675℃as Ti/V ratio decreases.PTT and NrT diagrams of MC precipitated from α matrices in different Ti-V microalloyed steels all exhibit C-shaped and inverse C-shaped curves.In addition,both theoretical calculation and experimental results show that when tempered at 600℃for 100 h,Ti2V2 steel shows the largest hardness value of 312 HV among the three steels tested because it has a larger volume fraction(0.364%),a larger precipitate density(1689 μm-2),and the smallest average size(8.4 nm)of(Ti,V)C precipitates.The theoretical calculations are consistent with experimental results,which indicates that the thermodynamics and kinetics model for(Ti,V)C precipitates is reliable and accurate. | Ke Zhang Xin-jun Sun Zhao-dong Li Kun Xu Tao Jia Zheng-hai Zhu Xiao-yu Ye Jun-yu Kang Qi-long Yong | 2021 | Journal of Iron and Steel Research(International)2021，28，8： | 2 |
| 17 | Prediction of properties distribution of 7B50 alloy thick plates after quenching and aging by quench factor analysis method显示文摘In the present work,continuous cooling curves were accurately measured by the modified Jominy specimen of 7B50 alloy during water-spray quenching tests.Besides,the time-temperature-properties(TTP) curves of this alloy were obtained during isothermal treatments.Based on the accurate cooling curves and TTP curves,the hardness distribution along the thickness direction of 7B50 alloy thick plates was predicted by quench factor analysis method.It is found that the quench sensitive temperature range of 7B50 alloy is 240-410℃,the nose temperature is 335℃,and the incubation period at the nose temperature is about 0.87 s.When 7B50 alloy was isothermal treated at 180-400℃ after solid solution treatment(470℃ for 1 h followed by 483℃ for 2 h),the exponent(n) in the Johnson-Mehl-Avrami equation is close to 1 until transformed fraction of new precipitates is up to 60%,indicating that new precipitates first grow into rodlike shape and then coarsen or thicken.When the distance is less than 65 mm from the spray quenching surface of the modified Jominy specimen,the deviation between the predicted and measured hardness is less than 2.7%,confirming the quench factor analysis method as the feasible way to predict the hardness distribution along the thickness direction of 7B50 alloy thick plates.When the distance from the spray quenching surface is 25 mm,the average cooling rate in quench sensitive temperature range is 9.93 ℃·s^-1,while the quench factor(τ) is 9.89 and the corresponding predicted hardness is HV 185.1 equivalent to 97.3% of the maximum measured hardness of 7B50 alloy in T6 temper. | Lei Kang Yi-Ran Zhou Gang Zhao Kun Liu Ni Tian | 2019 | Rare Metals2019，38，11： | 2 |
| 18 | High-throughput sequencing reveals the disruption of methylation of imprinted gene in induced pluripotent stem cells显示文摘在导致的 pluripotent 干细胞(iPSCs ) 积累的反常 epigenetic 修正是否能最终影响 iPSC pluripotency,仍然保持争论。为了探查这个问题,有一样的基因背景的 iPSC 线和 proviral 集成地点,被建立,并且每根 iPSC 线的 pluripotency 状态用 tetraploid (4N ) 被描绘互补试金。随后,基因表示和 “ 的全球 epigenetic 修正; 4N-ON ”并且相应 “ 4N-OFF ”iPSC 线通过深定序 mRNA 表示,小 RNA 侧面, histone 修正(H3K27me3, H3K4me3,和 H3K4me2 ) ,和 DNA methylation 的分析被比较。我们发现了印的基因的那 methylation, Zrsr1,一致地与减少的 pluripotency 在 iPSC 线被破坏。而且,破坏 methylation 不能被改进文化条件或 iPSCs 的 subcloning 救。而且,在 iPSCs 的 Zrsr1 和 pluripotency 状态的 hypomethylation 之间的关系进一步在线从另外的 reprogramming 系统导出的独立 iPSC 被验证。 | Gang Chang Shuai Gao Xinfeng Hou Zijian Xu Yanfeng Liu Lan Kang Yu Tao Wenqiang Liu Bo Huang Xiaochen Kou Jiayu Chen Lei An Kai Miao Keqian Di Zhilong Wang Kun Tan Tao Cheng Tao Cai Shaorong Gao Jianhui Tian | 2014 | Cell Research2014，24，3： | 2 |
| 19 | Detection and Analysis of Ebola Virus in Sierra Leone-China Friendship Biosafety Laboratory from March 11 to April 20, 2015显示文摘Ebola virus disease reemerged in Western Africa in 2014.Chinese Center for Disease Control and Prevention dispatched the first Ebola virus(EBOV)detection team to run newly established Sierra Leone-China Friendship Biological Safety Laboratory.The aims of study were to understand epidemiology,clinical manifestations and survival time of EBOV in patient’s blood.A total of 913specimens were tested between March 11 and | WANG Qin ZHANG Yong WANG Huan Yu DU Hai Jun NIE Kai SONG Jing Dong XIAO Kang LEI Wen Wen GUO Jian Qiang WEI He Jiang CAI Kun WANG Yan Hai WU Jiang Gerald BANGURA Idrissa Laybohr KAMARA DONG Xiao Ping | 2016 | Biomedical and Environmental Sciences2016，29，6： | 2 |
| 20 | AKT1 and AKT2 Promote Malignant Transformation in Human Brain Glioma LN229 Cells显示文摘 | Jian ZOU Kun WANG Lei HAN An-ling ZHANG Zhen-dong SHI Pei-yu PU Chun-sheng KANG | 2011 | Clinical oncology and cancer resexreh2011，8，3： | 2 |
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