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| 1 | Generation of iPSCs from mouse fibroblasts with a single gene, Oct4, and small molecules显示文摘由病毒的 transduction 的四抄写因素 Oct4, Klf4, Sox2 和 c-Myc 的介绍能导致体的房间的 reprogramming 进导致的 pluripotent 干细胞(iPSCs ) ,但是 iPSCs 的使用被病毒的交货系统的使用妨碍。导致化学药品的 reprogramming 把一条新奇途径提供给没有任何病毒的基于向量的基因修正,产生 iPSCs。尽管,以前的报告证明几个小分子能代替一些 reprogramming 因素至少二个抄写因素, Oct4 和 Klf4,仍然被要求从老鼠产生 iPSCs 胚胎的成纤维细胞。这里,我们识别特定的化学联合,它是足够的面对一个单个抄写因素从胚胎的老鼠和成年成纤维细胞允许 reprogramming, Oct4 在 20 天以内,代替 Sox2, Klf4 和 c-Myc。用这个处理产生的 iPSCs 类似于胚胎的干细胞以全球基因表示介绍的老鼠,在 vitro 并且在 vivo 的 epigenetic 地位和 pluripotency。我们也发现那 8 天 Oct4 正式就职是足够的面对小分子启用导致 Oct4 的 reprogramming,它建议 reprogramming 在开始的 8 天以内被开始并且独立于连续外长的 Oct4 表示。没有基因修正,这些发现将帮助 iPSCs 的未来产生,以及阐明位于 reprogramming 过程下面的分子的机制。 | Yanqin Li Qiang Zhang Xiaolei Yin Weifeng Yang Yuanyuan Du Pingping Hou Jian Ge Chun Liu Weiqi Zhang Xu Zhang Yetao Wu Honggang Li Kang Liu Chen Wu Zhihua Song Yang Zhao Yan Shi Hongkui Deng | 2011 | Cell Research2011，21，1： | 51 |
| 2 | The Genome of Artemisia annua Provides Insight into the Evolution of Asteraceae Family and Artemisinin Biosynthesis显示文摘Artemisia annua,通常已知的同样香甜的苦恼或 Qinghao,是到中国的一个灌木土著人并且长被用于药用的目的。A。annua 现在作为有势力抗疟药混合物的唯一的生来的来源全球性被栽培, artemisinin。这里,我们报导 A 的 1.74-gigabase 染色体的一个高质量的草稿集会。annua,高度异质接合,富于重复定序,并且包含 63 ? 226 编码蛋白质的基因,在定序的植物种类之中的最大的数字之一。我们发现了那,作为在 Asteraceae 的一些定序的染色体之一, A。annua 染色体包含对这大被子植物 clade 特定的很多基因。尤其是,扩大和编码涉及萜烯生合成的酶的基因的功能的多样化与 artemisinin biosynthetic 小径的进化一致。我们进一步由介绍那 A 的 transcriptome 揭示了。annua 发展了复杂 transcriptional 规章的网络位于 \O 下面 artemisinin 生合成。把转基因的 A 基于我们产生了的全面 genomic 和 transcriptomic 分析。artemisinin 高级的生产的 annua 线,它现在为大规模生产准备好了并且将从而帮助遇见增加 artemisinin 的全球需求的挑战。 | Qian Shen Lida Zhang Zhihua Liao Shengyue Wang Tingxiang Yan Pu Shi Meng Liu Xueqing Fu Qifang Pan Yuliang Wang Zongyou Lv Xu Lu Fangyuan Zhang Weimin Jiang Yanan Ma Minghui Chen Xiaolong Hao Ling Li Yueli Tang Gang Lv Yan Zhou Xiaofen Sun Peter E. Brodelius Jocelyn K.C. Rose Kexuan Tang | 2018 | Molecular Plant2018，11，6： | 47 |
| 3 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 4 | In vitro culture and differentiation of rat embryonic midbrain-derived neural stem cells显示文摘BACKGROUND:Midbrain-derived neural stem cells (mNSCs) can differentiate into functional mature dopaminergic neurons. The mNSCs are considered the ideal choice for cell therapy of Parkinson’s disease. OBJECTIVE: To isolate rat embryonic mNSCs and to observe the differentiation characteristics of mNSCs induced by cell growth-promoting factors. DESIGN,TIME AND SETTING: An in vitro cell culture study based on the molecular biology of nerve cells was carried out at the Institute of Clinical Medicine,China-Japan Friendship Hospital (China) from March to November 2007. MATERIALS: Sprague Dawley rats at embryonic day 14 were used in this study. Nestin antibody,β-Ⅲ tubulin antibody,glial fibrillary acidic protein (GFAP) antibody and cyclic nucleotide 3’-phosphohydrolase (CNPase) antibody were provided by Abcam; DMEM/F12 medium and N2 supplement were provided by In-vitrogen; epidermal growth factor (EGF) and fibroblast growth factor-2 (FGF2) were provided by R&D Sys-tems. METHODS: The ventral mesencephalon was dissected from embryonic day 14 rat embryos. By trypsin di-gestion and mechanical separation,the brain tissue was triturated into a fine single-cell suspension. The cells were cultured in 5 mL serum-free medium containing DMEM/F12,1% N2 supplement,20 ng/mL EGF and FGF2. The mNSCs at the third generation were coated with 10 μg/mL polylysine and induced to differenti-ate in the DMEM/F12 supplemented with 1% fetal bovine serum and 1% N2. MAIN OUTCOME MEASURES: The neural spheres of the third passage were identified by nestin im-munofluorescence; at the same time,the cells were induced to differentiate,and the types of differentiated cell were identified by immunofluorescence for βⅢ tubulin,GFAP and CNPase. RESULTS: Seven days after primary culture,a great many neurospheres could be obtained by successive pasage. Immunofluorescence assays showed that the neurospheres were nestin positive,and after differentia-tion,the cells expressed GFAP,CNPase and β-Ⅲ-tubulin. CONCLUSION: Embryonic day 14 rat mNSCs can differentiate into neuron-like cells and glial cells fol-lowing induction by EGF,FGF2 and N2 additive. | Xingli Deng Ruen Liu Zhongtang Feng Jing Guo Wu Wang Deqiang Lei Hongyan Li Zhihua Chen | 2008 | Neural Regeneration Research2008，3，11： | 19 |
| 5 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 6 | Family control,institutional environment and cash dividend policy:Evidence from China显示文摘Using a sample of 1486 Chinese A-share listed companies for the period 2004-2008,this study empirically tests the impact of family control,institutional environment and their interaction on the cash dividend policy of listed companies.Our results indicate that(1)family firms have a lower cash dividend payout ratio and propensity to pay dividends than non-family firms;(2) a favorable regional institutional environment has a significant positive impact on the cash dividend payout ratio and propensity to pay dividends of listed companies;and(3) the impact of the regional institutional environment on cash dividends is stronger in family firms than in non-family firms.Somewhat surprisingly,we find that controlling family shareholders in China may intensify Agency Problem Ⅰ(the owner-manager conflict) rather than Agency Problem Ⅱ(the controlling shareholder-minority shareholder conflict),and thus have a significant negative impact on cash dividend policy.In contrast,a favorable regional institutional environment plays a positive corporate governance role in mitigating Agency Problem 1 and encouraging family firms to pay cash dividends. | Zhihua Wei Shinong Wu Changqing Li Wei Chen | 2011 | China Journal of Accounting Research2011，，Z1： | 15 |
| 7 | Catalytic fast pyrolysis of Kraft lignin with HZSM-5 zeolite for producing aromatic hydrocarbons显示文摘 | Xiangyu LI Lu SU Yujue WANG Yanqing YU Chengwen WANG Xiaoliang LI Zhihua WANG | 2012 | Frontiers of Environmental Science & Engineering2012，6，3： | 14 |
| 8 | Performance deterioration modeling and optimal preventive maintenance strategy under scheduled servicing subject to mission time显示文摘Servicing is applied periodically in practice with the aim of restoring the system state and prolonging the lifetime. It is generally seen as an imperfect maintenance action which has a chief influence on the maintenance strategy. In order to model the maintenance effect of servicing, this study analyzes the deterioration characteristics of system under scheduled servicing. And then the deterioration model is established from the failure mechanism by compound Poisson process. On the basis of the system damage value and failure mechanism, the failure rate refresh factor is proposed to describe the maintenance effect of servicing. A maintenance strategy is developed which combines the benefits of scheduled servicing and preventive maintenance. Then the optimization model is given to determine the optimal servicing period and preventive maintenance time, with an objective to minimize the system expected life-cycle cost per unit time and a constraint on system survival probability for the duration of mission time. Subject to mission time, it can control the ability of accomplishing the mission at any time so as to ensure the high dependability. An example of water pump rotor relating to scheduled servicing is introduced to illustrate the failure rate refresh factor and the proposed maintenance strategy. Compared with traditional methods, the numerical results show that the failure rate refresh factor can describe the maintenance effect of servicing more intuitively and objectively. It also demonstrates that this maintenance strategy can prolong the lifetime, reduce the total lifetime maintenance cost and guarantee the dependability of system. | Li Dawei Zhang Zhihua Zhong Qianghui Zhai Yali | 2014 | Chinese Journal of Aeronautics2014，27，4： | 14 |
| 9 | Restricted allowable generalized quantum gates显示文摘An allowable generalized quantum gate(introduced by Long,Liu and Wang)has the form of U1 0 d kk k c U -=∑,where Uk's are unitary operators on a Hilbert space H and 1 0 1 d kkc -= |∑|≤and 1 k |c|≤(0≤k≤d-1).In this work we consider a kind of AGQGs,called restricted allowable generalized quantum gates(RAGQGs),satisfying 1 0 0 1 d kk c -= <∑||≤.Some properties of the set RAGQG(H)of all RAGQGs on H are established.Especially,we prove that the extreme points of RAGQG(H)are exactly unitary operators on H and that B(H)=R+RAGQG(H). | CAO HuaiXin LI Li CHEN ZhengLi ZHANG Ye GUO ZhiHua | 2010 | Chinese Science Bulletin2010，55，20： | 14 |
| 10 | Progress of applied research on TiO_2 photocatalysis-membrane separation coupling technology in water and wastewater treatments显示文摘Photocatalysis-membrane separation coupling technology has been a heavily researched area in water and wastewater treatment during recent years. The membrane separation process allows the photocatalyst to be easily separated, recovered and reused. More significantly, the membrane is efficient to maintain high flux of membranes as the photocatalyst can reduce the membrane fouling problem which is a hindrance in the development of membrane process. Moreover, some synergistic effects can also be produced, and thus the efficiency of water treatment is enhanced greatly. A comprehensive review of photocatalysis-membrane separation coupling technology is conducted with an insight into its configurations, theories involved, characteristics, and factors that influ-ence the coupling technology. In view of the existing problems, the prospects for future development are also proposed. | XIAO YuTang XU ShuangShuang LI ZhiHua AN XiaoHong ZHOU Lei ZHANG YongLai FU Q. Shiang | 2010 | Chinese Science Bulletin2010，55，14： | 13 |
| 11 | Rice functional genomics:decades'efforts and roads ahead显示文摘Rice(Oryza sativa L.)is one of the most important crops in the world.Since the completion of rice reference genome sequences,tremendous progress has been achieved in understanding the molecular mechanisms on various rice traits and dissecting the underlying regulatory networks.In this review,we summarize the research progress of rice biology over past decades,including omics,genome-wide association study,phytohormone action,nutrient use,biotic and abiotic responses,photoperiodic flowering,and reproductive development(fertility and sterility).For the roads ahead,cutting-edge technologies such as new genomics methods,high-throughput phenotyping platforms,precise genome-editing tools,environmental microbiome optimization,and synthetic methods will further extend our understanding of unsolved molecular biology questions in rice,and facilitate integrations of the knowledge for agricultural applications. | Rongzhi Chen Yiwen Deng Yanglin Ding Jingxin Guo Jie Qiu Bing Wang Changsheng Wang Yongyao Xie Zhihua Zhang Jiaxin Chen Letian Chen Chengcai Chu Guangcun He Zuhua He Xuehui Huang Yongzhong Xing Shuhua Yang Daoxin Xie Yaoguang Liu Jiayang Li | 2022 | Science China(Life Sciences)2022，65，1： | 12 |
| 12 | Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells显示文摘Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, Nod1 and Rip2 localize to insulin vesicles, recruiting Rab1a to direct insulin trafficking through the cytoplasm. Importantly, intestinal lysozyme liberates Nod1 ligands into the circulation, thus enabling long-range communication between intestinal microbes and islets. The intestine-islet crosstalk bridged by Nod1 ligands modulates host glucose tolerance. Our study defines a new type of inter-organ communication based on circulating bacterial signal molecules, which has broad implications for understanding the mutualistic relationship between microbes and host. | Qin Zhang Ying Pan Benhua Zeng Xiaojiao Zheng Haifang Wang Xueying Shen Hui Li Qian Jiang Jiaxu Zhao Zhuo-Xian Meng Pingping Li Zhengjun Chen Hong Wei Zhihua Liu | 2019 | Cell Research2019，29，7： | 11 |
| 13 | Granulation of filamentous microorganisms in a sequencing batch reactor with saline wastewater显示文摘Proliferation of filamentous microorganisms frequently leads to operational failure for activate sludge systems. In this study, it was found that filamentous microorganisms could grow in compact granular structure with 5% sodium chloride in the substrate. In the early period of experiment, coccoid and rode-like bacteria predominated in the yellowish-brown granules, and later the white and the black granules were developed by filamentous microorganisms. The filamentous granules exhibited low porosity and fast settling velocity, and were more compact even than bacteria granules. It was hypothesized that the elevated pH in the later period might be a possible reason for the compact growth of filamentous granules. However, the bacteria granules showed the high bioactivity in terms of specific oxygen utilizing rate, and comprised of a wider diversity of compounds based on the thermogravimetric evaluation. The findings in this study demonstrated that filamentous microbes could form compact granular structure, which may encourage the utilization of filamentous microorganisms rather than the inhibition of their growth, as the latter is frequently used for sludge bulking control. | Zhihua Li Ting Zhang Na Li Xiaochang Wang | 2010 | Journal of Environmental Sciences2010，22，1： | 11 |
| 14 | Changes in Lignin Content and Activity of Related Enzymes in the Endocarp During the Walnut Shell Development Period显示文摘Lignification was observed using the phloroglucinol–HCl method and the content of lignin,cellulose,and polyphenol and the activity of related enzymes were measured during development with the materials of walnut of ‘Zanmei' and ‘Zhenzhuxiang'.Results showed that lignification occurred at the beginning of June,initially took shape in mid-June and finished in late July.From shell lignification to harvest,the concentrations of lignin,cellulose,and phenolic content increased before harvest,but phenolic content decreased slightly.The activities of both POD and PAL decreased and PPO varied somewhat.Correlation analysis showed lignin content to be significantly positively correlated with the cellulose content.Phenolic content had a significant positive correlation with that of lignin.Phenolic content was positively correlated with cellulose.The activity of POD had a significant negative correlation with lignin,cellulose,and phenolic content,but it was positively correlated with the activity of PAL. | ZHAO Shugang WEN Jing WANG Hongxia ZHANG Zhihua LI Xibo | 2016 | Horticultural Plant Journal2016，2，3： | 11 |
| 15 | BZR1 Family Transcription Factors Function Redundantly and Indispensably in BR Signaling but Exhibit BRI1-Independent Function in Regulating Anther Development in Arabidopsis显示文摘BRASSINAZOLE-RESISTANT 1 family proteins(BZRs)are central transcription factors that govern brassinosteroid(BR)-regulated gene expression and plant growth.However,it is unclear whether there exists a BZR-independent pathway that mediates BR signaling.In this study,we found that disruption of all BZRs in Arabidopsis generated a hextuple mutant(bzr-h)displaying vegetative growth phenotypes that were almost identical to those of the null mutant of three BR receptors,bri1brl1brl3(bri-t).By RNA sequencing,we found that global gene expression in bzr-h was unaffected by 2 h of BR treatment.The anthers of bzr-h plants were loculeless,but a similar phenotype was not observed in bri-t,suggesting that BZRs have a BR signaling-independent regulatory role in anther development.By real-time PCR and in situ hybridization,we found that the expression of SPOROCYTELESS(SPL),which encodes a transcription factor essential for anther locule development,was barely detectable in bzr-h,suggesting that BZRs regulate locule development by affecting SPL expression.Our findings reveal that BZRs are indispensable transcription factors required for both BR signaling and anther locule development,providing new insight into the molecular mechanisms underlying the microsporogenesis in Arabidopsis. | Lian-Ge Chen Zhihua Gao Zhiying Zhao Xinye Liu Yongpeng Li Yuxiang Zhang Xigang Liu Yu Sun Wenqiang Tang | 2019 | Molecular Plant2019，12，10： | 11 |
| 16 | Biallelic mutations in CDC20 cause female infertility characterized by abnormalities in oocyte maturation and early embryonic development显示文摘Dear Editor,Previously,the Mendelian phe no types in huma n oocyte maturation arrest,fertilization failure and early embryonic arrest,are largely underestimated.In recent years,'missing'Men delian phe no types and genes in these processes are beginning to be uncovered by us and others(Huang et al.,2014;Alazami et al..2015;Feng et al.,2016;Xu et al.,2016;Chen et al.,2017;Sang et al.,2019).However,the genetic basis for majority of patients resulting from abnormalities in these phe no types remains to be elucidated. | Lin Zhao Songguo Xue Zhongyuan Yao Juanzi Shi Biaobang Chen Ling Wu Lihua Sun Yao Xu Zheng Yan Bin Li Xiaoyan Mao Jing Fu Zhihua Zhang Jian Mu Wenjing Wang Jing Du Shuai Liu Jie Dong Weijie Wang Qiaoli Li Lin He Li Jin Xiaozhen Liang Yanping Kuang Xiaoxi Sun Lei Wang Qing Sang | 2020 | Protein & Cell2020，11，12： | 10 |
| 17 | Hepatitis C virus core upregulates the methylation status of the RASSF1A promoter through regulation of SMYD3 in hilar cholangiocarcinoma cells显示文摘增加的证据被积累了在肿瘤开始显示 epigenetic 规定的重要角色。以前,我们观察到病毒核心(HCVc ) 蛋白质导致了的丙肝的 transfection 在正常胆汁的房间的恶意的转变,和那肿瘤 suppressor 基因 RASSF1A 是在由在倡导者区域的 hypermethylation 的许多 hilar cholangiocarcinoma 病人的 downregulated。在现在的学习,我们发现集合和 MYND 包含域的蛋白质 3 (SMYD3 ) ,新奇 histone methyltransferase,在有 HCV 感染的那些特别是在 cholangiocarcinoma 病人的 overexpressed。进 hilar cholangiocarcinoma 房间的 HCVc 的 Transfection 衬里 QBC939 和 FRH0201 能 upregulate SMYD3 的表示并且支持房间生长,它与我们的临床的研究的结果一致。这现象显示 SMYD3 与有 HCV 感染的 cholangiocarcinoma 开始的 epigenetic 规定有关。SMYD3 的 Overexpression 能禁止 RASSF1A 表示,而由 siRNA 的 SMYD3 的抑制改进了它的表示。Methylation 特定的聚合酶链反应(MS-PCR ) 结果证明 RASSF1A 倡导者的 methylation 地位被 SMYD3 调整。在结论, HCVc 能 upregulate 通过 SMYD3 的规定的 RASSF1A 倡导者的 methylation 地位,和 histone methylation 可以由未知机制影响下游的基因的 DNA methylation。 | Ning Guo Rufu Chen Zhihua Li Yonggang Liu Di Cheng Quanbo Zhou Jiajia Zhou Qing Lin | 2011 | Acta Biochimica et Biophysica Sinica2011，43，5： | 8 |
| 18 | Release characteristic of different classes of sodium during combustion of Zhun-Dong coal investigated by laser-induced breakdown spectroscopy显示文摘Serious fouling and slagging problems are associated with the combustion of Chinese Zhun-Dong coal due to its high content of sodium(Na). Understanding the release characteristic of Na during the combustion is essential to viable utilization of this coal. In this work, coal samples were treated with a sequence of solvents: water(H2O), ammonium acetate(NH4Ac), hydrochloric acid(HCl), and the release characteristics of various classes of Na during coal combustion were investigated using the technique of laser-induced breakdown spectroscopy. The relative contribution of various Na classes to the Na release during each combustion stage was found to be similar, in the order of H2O-soluble Na [ NH4 Acsoluble Na [ HCl-soluble Na [ insoluble Na. Sodium released during the devolatilization stage can be attributed to each of the sodium classes. After the devolatilization stage,H2O-soluble Na and NH4Ac-soluble Na dominated the Na release during both char and ash stages. Over 64 % of the total Na released during combustion comes from the H2O-soluble Na, which suggests that the Na release during the combustion of Zhun-Dong coal can be reduced effectively after treatment by H2 O washing. | Yong He Kunzan Qiu Ronald Whiddon Zhihua Wang Yanqun Zhu Yingzu Liu Zhongshan Li Kefa Cen | 2015 | Science Bulletin2015，60，22： | 8 |
| 19 | Geochemistry and petrogenesis of Quaternary volcanism from the islets in the eastern Beibu Gulf: evidence for Hainan plume显示文摘Some of the islets in the eastern Beibu Gulf are covered by Quaternary volcano strata.The rock samples from these islets mainly consist of quartz tholeiites(at Shenjiandao),olivine tholeiites(at Linshidao and Xieyangdao)and alkali basalts(at Yangpubi and Jianshidao),and basically represent four periods of the Quaternary volcanism of Hainan Island and its adjacent regions.Except for the samples from Shenjiandao,most of the Quaternary volcanics of these islets belong to alkali magma series.The trace element characteristics of all of these samples show they are OIB(oceanic island basalt)-like,which implies that their deep geodynamic setting may be related to a mantle plume.The Sr-Nd-Pb isotopic compositions show that the mantle source beneath the Quaternary strata can be regarded as a result of binary mixing between a depleted,DMM(depleted MORB mantle)-like source and an enriched mantle type 2(EM2).The EM2 may be originated from the Hainan mantle plume,and has been metasomatized by carbonaceous fluids released from ancient recycled oceanic crust at an asthenospheric mantle level.These features,together with typical trace element ratios,reflect that the parent magma was not subjected to crustal contamination during its ascent to the surface.This study provides further petrological and geochemical evidence for the existence of the Hainan mantle plume. | LI Naisheng YAN Quanshu CHEN Zhihua SHI Xuefa | 2013 | Acta Oceanologica Sinica2013，32，12： | 7 |
| 20 | Effectiveness of fluidized pellet bed for removing soluble contaminants显示文摘Fluidized pellet bed(FPB) has been successfully applied in water and wastewater treatment. However,the removal mechanism of contaminants especially the soluble ones,is still unclear. This study aimed to evaluate the effectiveness of FPB reactor for removing soluble contaminants from synthetic wastewater. By only coagulation through jar test operation with addition of polyaluminium chloride(PACl) as primary coagulant and polyacryamide(PAM) as coagulant-aid,the removals of soluble chemical oxygen demand(COD) ,total phosphorus(TP) ,and NH4+-N were found to be only 2.2%-7.5%,5.7%-25.5%,and 9.9%-18.5%,respectively. However,by FPB operation under the same dosage of coagulants,these values increased to 82.7%,37.2%,and 50%,indicating that the formation of pellets in the FPB effectively enhanced the removal of soluble contaminants. By careful comparison of the settleablility and filterability of the pollutants after coagulation,the originally soluble contaminants could be divided into three groups,namely:(1) coagulated-and-settleable,(2) coagulated-but-nonsettleable,and(3) uncoagulable. It was found that not only the first two groups but also a large part of the third group could be effectively removed by FPB operation. However,the mechanism for the removal of the uncoagulable pollutants by FPB operation still needs further investigation. | WANG Xiaochang,LI Zhihua,WANG Zhen,LI Jinrong,LI Jiayu,CHEN Rong Key Laboratory of Northwest Water Resource,Environment and Ecology,MOE,Xi’an University of Architecture and Technology,Xi’an 710055,China | 2009 | Journal of Environmental Sciences2009，21，1： | 7 |
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