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| 1 | Coinfection with influenza A virus enhances SARS-CoV-2 infectivity显示文摘The upcoming flu season in the Northern Hemisphere merging with the current COVID-19 pandemic raises a potentially severe threat to public health.Through experimental coinfection with influenza A virus(IAV)and either pseudotyped or live SARS-CoV-2 virus,we found that IAV preinfection significantly promoted the infectivity of SARS-CoV-2 in a broad range of cell types.Remarkably,in vivo,increased SARS-CoV-2 viral load and more severe lung damage were observed in mice coinfected with IAV.Moreover,such enhancement of SARS-CoV-2 infectivity was not observed with several other respiratory viruses,likely due to a unique feature of IAV to elevate ACE2 expression.This study illustrates that IAV has a unique ability to aggravate SARS-CoV-2 infection,and thus,prevention of IAV infection is of great significance during the COVID-19 pandemic. | Lei Bai Yongliang Zhao Jiazhen Dong Simeng Liang Ming Guo Xinjin Liu Xin Wang Zhixiang Huang Xiaoyi Sun Zhen Zhang Lianghui Dong Qianyun Liu Yucheng Zheng Danping Niu Min Xiang Kun Song Jiajie Ye Wenchao Zheng Zhidong Tang Mingliang Tang Yu Zhou Chao Shen Li Zhou Yu Chen Huan Yan Ke Lan Ke Xu | 2021 | Cell Research2021，31，4： | 16 |
| 2 | PepperHub, an Informatics Hub for the Chili Pepper Research Community显示文摘 | Feng Liu Huiyang Vu Yingtian Deng Jingyuan Zheng Minglei Liu Lijun Ou Bozhi Yang Xiongze Dai Yanqing Ma Shengyu Feng Shuang He Xuefeng Li Zhuqing Zhang Wenchao Chen Shudong Zhou Rong Chen Minmin Liu Sha Yang Ruimin Wei Huadong Li Feng Li Bo Ouyang Xuexiao Zou | 2017 | Molecular Plant2017，10，8： | 13 |
| 3 | Comparative study on the effects and efficiencies of three sublimation drying methods for mushrooms显示文摘Freeze drying(FD)yields the best quality of dried mushrooms but needs long drying time and higher cost.Air drying(AD)gives relatively poor product quality.In order to achieve faster drying along with high product quality,microwave freeze drying(MFD)and atmospheric freeze drying(AFD)were developed to dry mushrooms.By comparison of three sublimation drying processes,it was concluded that FD could lead to the best product quality,but cost the highest energy consumption.AFD mushrooms had the worst quality and longest drying time,but the lowest energy consumption.Compared with FD and AFD,MFD could get relatively acceptable quality and drying efficiency.As a result,MFD can be used to replace traditional FD,and AFD also should be popularized because of its low energy consumption. | Duan Xu Liu Wei Ren Guangyue Liu Wenchao Liu Yunhong | 2015 | International Journal of Agricultural and Biological Engineering2015，8，1： | 13 |
| 4 | Examining the influence of the implementation of Major Function-oriented Zones on built-up area expansion in China显示文摘中国实现了国家策略让主要面向功能的地区(MFOZ ) 自从 2010,实现国家持续开发的目标。分析并且比较时间空间的特征和差别在的这研究布满建筑物为用一个中国 s 陆地使用数据库(CLUD ) 的瓷器 MFOZ 的区域在 2000-2010 和 2010-2013 的时期源于高分辨率的遥远地察觉到的图象。总结:(1 ) 百分比布满建筑物在每 MFOZ 的区域是显著地不同的,基于主要函数的分发揭示国家陆地开发的坡度特征。(2 ) 年度生长在布满建筑物,在最佳的发展地区(ODZ ) 的区域与时期 2000-2010 相比在 2010-2013 期间显著地减少了年度生长在布满建筑物在重要进展地区(KDZ ) 的区域,农业生产地区(APZ ) 和关键生态的功能地区(KEFZ ) 显著地增加了。(3 ) 在 ODZ,的平均年度增加布满建筑物在长江三角洲区域的区域比在另外的区域显著地高;平均区域增加和增加的率布满建筑物在 KDZ 的区域比在另外的区域在西方的区域是更快的;平均年度区域生长布满建筑物在在东北的 APZ 的区域,中央、西方的区域平均象以前的十年一样两次高;在动态度的变化和增加的年度率布满建筑物区域在在中央区域的 KEFZ 是很著名的。(4 ) 空间模式和特征布满建筑物在时期 2010-2013 的区域扩大为 MFOZ 反映了计划的坡度特征。但是率局部地增加在布满建筑物在 ODZ, APZ 和 KEFZ 的区域是快的,有效措施必须因此在国家、地区性的政策的实现被采用。结论显示了这些方法,结果为在在中国优化国家陆地开发的未来规定策略是有意义的。 | LIU Wenchao LIU Jiyuan KUANG Wenhui NING Jia | 2017 | Journal of Geographical Sciences2017，27，6： | 12 |
| 5 | Metallogenic model and prognosis of the Shuiyindong super-large strata-bound Carlin-type gold deposit, southwestern Guizhou Province, China显示文摘The Shuiyindong deposit is one of the largest (more than 100 tonnes of Au) and highest grade (more than 7×10-6-10×10-6), strata-bound Carlintype gold deposits in southwestern Guizhou Province, China. The deposit is controlled by both structure and favorable lithology. It is situated near the axis of the striking Huijiabao anticline and is hosted in bioclastic limestone of the Permian Longtan Formation. Gold mineralization occurred under low temperature with Th of 220℃± and is closely associated with decarbonation, silicification, sulfidation and dolomitization. The deposit has a characteristic elemental assemblage of Au-As-Hg-Tl. Studies of geochemistry and isotope compositions indicated that the ore-bearing materials and fluids of the gold deposit mainly originated from a plutonic source, and possess a mixing feature with the strata matter during transportation from mantle to crust. Fluid inclusions in vein quartz from the gold deposit are rich in volatile flux, indicating that metallogenic fluid is an overpres-sured one. The activity and geothermal state of the Earth's crust in the long period of time are favorable for the formation of overpressured fluids in a large area, and extensive structures would drive the fluids into ore-forming sys-tem and make gold deposits formed. The complexity of structural movement in the upper crust of southwestern Guizhou Province resulted in complicated gold mineralization. Through metallogenic prognosis and exploration, the proven reserves of the deposit increased by tens of tonnes of Au and the deposit has become a super-large strata-bound Carlin-type gold deposit. | ZHANG Yu XIA Yong SU Wenchao TAO Yan ZHANG Xingchun LIU Jianzhong DENG Yiming | 2010 | Chinese Journal Of Geochemistry2010，29，2： | 8 |
| 6 | Numerical investigation of dual-porosity model with transient transfer function based on discrete-fracture model显示文摘Based on the characteristics of fractures in naturally fractured reservoir and a discrete-fracture model, a fracture network numerical well test model is developed.Bottom hole pressure response curves and the pressure field are obtained by solving the model equations with the finite-element method. By analyzing bottom hole pressure curves and the fluid flow in the pressure field, seven flow stages can be recognized on the curves. An upscaling method is developed to compare with the dual-porosity model(DPM). The comparisons results show that the DPM overestimates the inter-porosity coefficient λ and the storage factor ω. The analysis results show that fracture conductivity plays a leading role in the fluid flow. Matrix permeability influences the beginning time of flow from the matrix to fractures. Fractures density is another important parameter controlling the flow. The fracture linear flow is hidden under the large fracture density.The pressure propagation is slower in the direction of larger fracture density. | Yizhao WAN Yuewu LIU Weiping OUYANG Guofeng HAN Wenchao LIU | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，5： | 7 |
| 7 | A numerical approach for pressure transient analysis of a vertical well with complex fractures显示文摘A new well test model for a vertical fractured well is developed based on a discrete-fracture model in which the fractures are discretized as one dimensional(1-D) entities.The model overcomes the weakness of complex meshing,a large number of grids, and instability in conventional stripe-fracture models. Then, the discrete-fracture model is implemented using a hybrid element finite-element method.Triangular elements are used for matrix and line elements for the fractures. The finite element formulation is validated by comparing with the semi-analytical solution of a single vertical fractured well. The accuracy of the approach is shown through several examples with different fracture apertures,fracture conductivity, and fracture amount. Results from the discrete-fracture model agree reasonably well with the stripefracture model and the analytic solutions. The advantages of the discrete-fracture model are presented in mesh generation, computational improvement, and abilities to handle complex fractures like wedge-shaped fractures and fractures with branches. Analytical results show that the number of grids in the discrete-fracture model is 10 % less than stripefracture model, and computational efficiency increases by about 50 %. The more fractures there are, the more the computational efficiency increases. | Yizhao Wan Yuewu Liu Wenchao Liu Guofeng Han Congcong Niu | 2016 | Acta Mechanica Sinica2016，32，4： | 7 |
| 8 | Effect of quadratic pressure gradient term on a one-dimensional moving boundary problem based on modified Darcy's law显示文摘A relatively high formation pressure gradient can exist in seepage flow in low-permeable porous media with a threshold pressure gradient, and a significant error may then be caused in the model computation by neglecting the quadratic pressure gradient term in the governing equations.Based on these concerns, in consideration of the quadratic pressure gradient term, a basic moving boundary model is constructed for a one-dimensional seepage flow problem with a threshold pressure gradient. Owing to a strong nonlinearity and the existing moving boundary in the mathematical model,a corresponding numerical solution method is presented.First, a spatial coordinate transformation method is adopted in order to transform the system of partial differential equations with moving boundary conditions into a closed system with fixed boundary conditions; then the solution can be stably numerically obtained by a fully implicit finite-difference method. The validity of the numerical method is verified by a published exact analytical solution. Furthermore, to compare with Darcy's flow problem, the exact analytical solution for the case of Darcy's flow considering the quadratic pressure gradient term is also derived by an inverse Laplace transform.A comparison of these model solutions leads to the conclusion that such moving boundary problems must incorporatethe quadratic pressure gradient term in their governing equations; the sensitive effects of the quadratic pressure gradient term tend to diminish, with the dimensionless threshold pressure gradient increasing for the one-dimensional problem. | Wenchao Liu Jun Yao Zhangxin Chen Yuewu Liu | 2016 | Acta Mechanica Sinica2016，32，1： | 7 |
| 9 | The occurrence of gold in hydrothermal sulfide at Southwest Indian Ridge 49.6°E显示文摘Massive sulfide precipitates found in the Southwest Indian Ridge(SWIR) 49.6°E hydrothermal field are enriched in gold.Here,the mineralogy and mineral chemistry of these massive sulfides to constrain the process of gold precipitation were studied.Sulfide samples in this field include lowertemperature Zn-rich sulfides and relative higher-temperature Fe-rich sulfides.Zn-rich sulfides are dominated by sphalerite-pyrite-chalcopyrite assemblages,with concentrations of gold ranging from 9.08 to 17.0 μg/g.Fe-rich sulfides consist mainly of pyrite-marcasite-isocubanite assemblages,with gold concentrations from 2.17 to 3.79 μg/g.The significant enrichment in gold within the lowertemperature Zn-rich sulfides and the effective separation of Zn and Fe in hydrothermal precipitates at the surface of this field are here interpreted to reflect the strong temperature dependence of gold transportation and deposition within the sulfides.In Zn-rich samples,large amounts of isolated native gold grains were identified.They were found mainly as inclusions up to 8 μm in diameter,occupying porous cavities in sphalerite or in the elevated iron content rim of sphalerite.The fineness of the gold ranged from 810 to 830.Unlike previously published results on other hydrothermal fields,these data show a low gold fineness values in SWIR 49.6°E.The FeS content of sphalerite associated with gold grains ranged from 3.2 mole % to 18.9 mole %.This was higher than in other fields,indicating that the sulfur activity is relatively low during the gold precipitation process and that sulfur activity may be one of the main factors affecting gold fineness in the SWIR 49.6°E hydrothermal field.Evidence regarding gold fineness and sulfur activity suggests that gold was quite likely transported as AuHS0 rather than as a Au(HS)-2 complex. | YE Jun SHI Xuefa YANG Yaomin LI Naisheng LIU Jihua SU Wenchao | 2012 | Acta Oceanologica Sinica2012，31，6： | 7 |
| 10 | Combining User-Based and Item-Based Models for Collaborative Filtering Using Stacked Regression显示文摘Collaborative filtering can be classified into user-based or item-based methods according to different assumptions. Our experiment results show that both userbased and item-based methods can reach a certain degree of accuracy, but the recommendation coverage of these two methods is significantly different. This paper qualitatively analyzes the advantages and disadvantages of such two methods, and found that user-based methods advantage in recommending popular items while item-based methods perform better at suggesting long tail items. Based on this analysis, we proposes a novel machine learning framework to systematically combine both. We train a model for each user-item pair for discovering the local preference of the user or item over both methods, and effectively combine user-based and item-based predictions using the preference information. Experiment results show that our approach can significantly improve the recommendation quality, and to a certain extend, alleviate the data sparsity problem. | LIU Qingwen XIONG Yan HUANG Wenchao | 2014 | Chinese Journal of Electronics2014，23，4： | 5 |
| 11 | Numerical and experimental studies on solidification of AZ80 magnesium alloy under out-of-phase pulsed magnetic field显示文摘For obtaining the finer grains of magnesium alloy,a novel combined pulsed magnetic field with different initial phases,also called out-ofphase pulsed magnetic field(OPPMF),was applied to study the solidification structure of AZ80 magnesium alloy.The numerical simulation was simultaneously conducted to investigate the refinement mechanisms.The experimental results showed that the macrostructure could be effectively refined by applying external magnetic field.Meanwhile,finer grains were obtained with the higher current intensity.However,the increase of current intensity could only refine the grains to about 0.5 mm.Furthermore,compared to a single pulsed magnetic field(PMF)and alternating series of OPPMF(Connection II),a finer structure was observed when the consecutive series of OPPMF(Connection I)was imposed.In contrast with a single PMF and Connection II,the numerical results showed that the greater axial Lorentz force was obtained under the Connection I,generating the stronger forced flow in the melt.It is believed that abundant nuclei could detach from the mold wall and move faster into the interior melt due to the stronger forced flow;besides,the lower superheat and greater temperature uniformity in bulk melt were realized,accounting for the finest structures under the Connection I. | Wenchao Duan Siqi Yin Wenhong Liu Zhong Zhao Kun Hu Ping Wang Jianzhong Cui Zhiqiang Zhang | 2021 | Journal of Magnesium and Alloys2021，9，1： | 5 |
| 12 | Structuring Nonlinear Wavefront Emitted from Monolayer Transition-Metal Dichalcogenides显示文摘The growing demand for tailored nonlinearity calls for a structure with unusual phase discontinuity that allows the realization of nonlinear optical chirality,holographic imaging,and nonlinear wavefront control.Transition-metal dichalcogenide(TMDC)monolayers offer giant optical nonlinearity within a few-angstrom thickness,but limitations in optical absorption and domain size impose restriction on wavefront control of nonlinear emissions using classical light sources.In contrast,noble metal-based plasmonic nanosieves support giant field enhancements and precise nonlinear phase control,with hundred-nanometer pixellevel resolution;however,they suffer from intrinsically weak nonlinear susceptibility.Here,we report a multifunctional nonlinear interface by integrating TMDC monolayers with plasmonic nanosieves,yielding drastically different nonlinear functionalities that cannot be accessed by either constituent.Such a hybrid nonlinear interface allows second-harmonic(SH)orbital angular momentum(OAM)generation,beam steering,versatile polarization control,and holograms,with an effective SH nonlinearityχ^((2))of~25 nm/V.This designer platform synergizes the TMDC monolayer and plasmonic nanosieves to empower tunable geometric phases and large field enhancement,paving the way toward multifunctional and ultracompact nonlinear optical devices. | Xuanmiao Hong Guangwei Hu Wenchao Zhao Kai Wang Shang Sun Rui Zhu Jing Wu Weiwei Liu Kian Ping Loh Andrew Thye Shen Wee Bing Wang Andrea Alù Cheng-Wei Qiu Peixiang Lu | 2020 | Research2020，，1： | 5 |
| 13 | The occurrence of diffuse axonal injury in the brain:associated with the accumulation and clearance of myelin debris显示文摘The accumulation of myelin debris may be a major contributor to the inflammatory response after diffuse axonal injury. In this study, we examined the accumulation and clearance of myelin debris in a rat model of diffuse axonal injury. Oil Red O staining was performed on sections from the cerebral cortex, hippocampus and brain stem to identify the myelin debris. Seven days after diffuse axonal injury, many Oil Red O-stained particles were observed in the cerebral cortex, hippocampus and brain stem. In the cerebral cortex and hippocampus, the amount of myelin debris peaked at 14 days after injury, and decreased significantly at 28 days. In the brain stem, the amount of myelin debris peaked at 7 days after injury, and decreased significantly at 14 and 28 days. In the cortex and hippocampus, some myelin debris could still be observed at 28 days after diffuse axonal injury. Our findings suggest that myelin debris may persist in the rat central nervous system after diffuse axonal injury, which would hinder recovery. | Liang Wen Jun Xu Tianxiang Zhan Hao Wang Xin Huang Wenchao Liu Xiaofeng Yang Renya Zhan | 2014 | Neural Regeneration Research2014，9，21： | 4 |
| 14 | 1 T moderate intensity static magnetic field affects Akt/mTOR pathway and increases the antitumor efficacy of m TOR inhibitors in CNE-2Z cells显示文摘Static magnetic field(SMF) has been known to affect cell proliferation in a cell-type-dependent manner,while the mechanism still remains unclear. We found that 1T moderate intensity SMF inhibits cell proliferation of nasopharyngeal carcinoma CNE-2Z cells and the Akt/m TOR signaling pathway, which is upregulated in many cancers. m TOR inhibitors are potential chemodrugs, but their clinical effects are limited by the feedback reactivation of other signaling components such as EGFR and Akt.We showed that 1 T SMF increases the antitumor efficacy of m TOR inhibitor Torin 2. In addition, 1 T SMF increases the inhibition efficiency on m TOR substrates phosphorylation and represses the m TOR inhibitor-induced feedback reactivation of EGFR and Akt. Our study not only demonstrates that m TOR/Akt pathway is one of the molecular targets of SMFs in cells, but also reveals the clinical potentials of combinations of m TOR inhibitors and SMFs in cancer treatment. | Lei Zhang Xingxing Yang Juanjuan Liu Yan Luo Zhiyuan Li Xinmiao Ji Wenchao Wang Xin Zhang | 2015 | Science Bulletin2015，60，24： | 4 |
| 15 | 2D MXene-Based Materials for Electrocatalysis显示文摘MXenes,as an emerging 2D material,are expected to exert a great influence on future energy storage and conversion technologies.In this review,we systematically summarize recent advances in MXene-based materials in electrocatalysis,particularly in the hydrogen evolution,oxygen evolution,oxygen reduction,nitrogen reduction,and CO2 reduction reactions.Crucial factors influencing the properties of these materials,such as functional groups,conductivity,and interface,are discussed,and challenges to the future development of MXene-based electrocatalysts are presented. | Jiapeng Liu Wenchao Peng Yang Li Fengbao Zhang Xiaobin Fan | 2020 | Transactions of Tianjin University2020，26，3： | 4 |
| 16 | High energy-storage properties of Bi_(0.5)Na_(0.5)TiO_3-BaTiO_3-SrTi_(0.875)Nb_(0.1)O_3 lead-free relaxor ferroelectrics显示文摘New lead-free ferroelectric(0.94-x)Bio_(0.5)Na_(0.5)TiO_3-0.06 BaTiO_(3-x)SrTi_(0.875)Nb_(0.1)O_3(BNBT-STN,x = 0 and 0.2)are synthesized by using a solid state reaction process. In this work, an obvious evolution of dielectric relaxation behavior and slim P-E hysteresis loops with high Pmax and low Pr is observed for BNBT-0.2 STN,indicating the dominant of ergodic relaxor phase with dynamic polar nano-regions(PNRs). A relatively large recoverable energy density(Wrec = 1.17 J/cm^3) with high energy efficiency(η= 91%) is obtained. Furthermore, it shows small variation(9%) in the temperature range of 30-150 ℃ and fatigue-free behavior,which can be attributed to the absence of ferroelectric domain in the relaxor phase. The achievement of these characteristics provides that tailoring by B-site vacancies is a potential route when designing a new energy-storage system for BNT-based relaxor ferroelectric materials. | Jing Shi Xiao Liu Wenchao Tian | 2018 | Journal of Materials Science & Technology2018，34，12： | 4 |
| 17 | A cryptic inhibitor of cytokinin phosphorelay controls rice grain size显示文摘Plant hormone cytokinin signals through histidine-aspartic acid(H-D)phosphorelay to regulate plant growth and development.While it is well known that the phosphorelay involves histidine kinases,histidine phosphotransfer proteins(HPs),and response regulators(RRs),how this process is regulated by external components remains unknown.Here we demonstrate that protein phosphatase with kelch-like domains(PPKL1),known as a signaling component of steroid hormone brassinosteroid,is actually a cryptic inhibitor of cytokinin phosphorelay in rice(Oryza sativa).Mutation at a specific amino acid D364 of PPKL1 activates cytokinin response and thus enlarges grain size in a semi-dominant mutant named s48.Overexpression of PPKL1 containing D364,either with the deletion of the phosphatase domain or not,rescues the s48 mutant phenotype.PPKL1 interacts with OsAHP2,one of authentic HPs,and D364 resides in a region resembling the receiver domain of RRs.Accordingly,PPKL1 can utilize D364 to suppress OsAHP2-to-RR phosphorelay,whereas mutation of D364 abolishes the effect.This function of PPKL1 is independent of the phosphatase domain that is required for brassinosteroid signaling.Importantly,editing of the D364-residential region produces a diversity of semi-dominant mutations associated with variously increased grain sizes.Further screening of the edited plants enables the identification of two genotypes that confer significantly improved grain yield.Collectively,our study uncovers a noncanonical cytokinin signaling suppressor and provides a robust tool for seed rational design. | Dapu Liu He Zhao Yunhua Xiao Guoxia Zhang Shouyun Cao Wenchao Yin Yangwen Qian Yanhai Yin Jinsong Zhang Shouyi Chen Chengcai Chu Hongning Tong | 2022 | Molecular Plant2022，15，2： | 3 |
| 18 | Effect of different twirling and rotating acupuncture manipulation techniques on the blood flow perfusion at acupoints显示文摘OBJECTIVE: To analyze the effect of different twirling and rotating acupuncture manipulation techniques on the blood flow perfusion at acupoints to provide a reference for the study of acupoint specificity and the quantification and effectiveness of acupuncture methods. METHODS: Twenty healthy male or female college students each received four different acupuncture manipulation techniques, including simple acupuncture, uniform reinforcing-reducing needling, twirling reinforcing needling, and twisting reducing needling. The self-control method was applied. Acupuncture was performed by an acupuncture manipulation simulator at Neiguan (PC 6) and Zusanli (ST 36). The process of twirling and rotating was divided into seven timepoints. The PeriCam Perfusion Speckle Imager (PSI) System was used to collect the blood flow perfusion data at each acupoint. The specificity of twirling and rotating acupuncture manipulation was analyzed based on changes in the curve, video, and numerical blood flow perfusion data at each timepoint. RESULTS: There were two peaks in the blood flow perfusion curve of twirling and rotating acupuncture manipulation;one appeared after 3 min of needle retention, and the other appeared 3 min after needle removal. The blood flow perfusion parameters showed that the greatest differences between the four manipulation techniques occurred after 5 and 10 min of needle retention. The specificity of various manipulation techniques was most obvious at these two timepoints. There were significant differences between the four manipulation groups in the blood flow perfusion and the relative change rates of blood flow perfusion at each timepoint. CONCLUSION: Laser speckle imaging enables the real-time, non-invasive, rapid, and accurate collection of blood flow perfusion data during acupuncture. This imaging technique enables the easy attainment of various parameters such as visual images, two-dimensional curves, and data tables. At various timepoints, the four groups significantly differed regarding changes in blood flow perfusion and relative change rates of blood flow perfusion, which facilitated the differentiation of the four acupuncture manipulation methods. Based on this, further analysis could be conducted to study spatial distribution characteristics such as the influence area and flare area. The frequency domain analysis of acupuncture manipulation curves is important in the study of the dose-effect relationship and specificity of acupuncture manipulation. | Xu Gang Xi Qianhui Tang Wenchao Liu Tangyi Gao Ming Li Shaoxiong Wen Junling Yang Huayuan | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 3 |
| 19 | A cynomolgus monkey with naturally occurring Parkinson’s disease显示文摘Evidence for the existence of monkeys with spontaneous Parkinson’s disease(PD)has been lacking.Here,we screened macaque colonies at the Kunming Primate Research Center(Association for Assessment and Accreditation of Laboratory Animal Care(AAALAC)accredited),Kunming Institute of Zoology,Chinese Academy of Sciences,which has a large population of monkeys(>2400),to identify naturally occurring PD monkeys. | Hao Li Ling-Yan Su Lixin Yang Min Li Qianjin Liu Zhenhui Li Yan Hu Hongwei Li Shihao Wu Wenchao Wang Yingzhou Hu Zhengbo Wang Joshua DRizak Baihui Huang Min Xu Jing Wu Long-Bao Lv Christoph W.Turck Yong Yin Yong-Gang Yao Bing Su Xintian Hu | 2021 | National Science Review2021，8，3： | 3 |
| 20 | Clear mortality gap caused by graft macrosteatosis in Chinese patients after cadaveric liver transplantation显示文摘Background:Liver transplantation(LT)is one of the most effective surgical treatment for patients with end-stage liver disease.Steatosis is a contributor for inferior graft quality.But its impact and safety on transplantation was less assessed in Chinese patients.Methods:Graft steatosis and related information involved in recipients,donors and surgical procedures were retrospectively collected from 239 patients.Results:Donor macrosteatosis(MaS)caused about 2.14 and 2.80 folds of increment on patient and graft mortality.Dose-response analysis revealed prominent risk of grafts on overall patient/organ mortality when MaS content exceeded 10%(P<0.05).Noteworthy,deaths were only observed in MaS group when concurrent with extremely higher post-transplant alanine aminotransferase(ALT,64%).However,microsteatosis(MiS)grafts didn’t affect outcomes after LT.In a cohort of Chinese patients,MaS had comprehensive effects on post-transplant outcomes with relatively lower safety threshold at 10%.Mortality gap caused by MaS grafts was observed in patients with severer ischemia reperfusion injury.Conclusions:Our study revealled the graft MaS affected the post-transplant outcomes in lower risk cutoff in Chinese patients.Further study is worthy to validate these results and investigate inner mechanism under the phenomenon. | Zhengtao Liu Wenchao Wang Li Zhuang Jingfeng Liu Shuping Que Dan Zhu Linfang Dong Jian Yu Lin Zhou Shusen Zheng | 2020 | Hepatobiliary Surgery and Nutrition2020，9，6： | 2 |
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