|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Minimally invasive surgery alone compared with intensity-modulated radiotherapy for primary stage I nasopharyngeal carcinoma显示文摘Background:The National Comprehensive Cancer Network guidelines recommend intensity-modulated radiotherapy(IMRT)as the primary curative treatment for newly diagnosed nasopharyngeal carcinoma(NPC),but the radiation-related complications and relatively high medical costs remain a consequential burden for the patients.Endoscopic nasopharyngectomy(ENPG)was successfully applied in recurrent NPC with radiation free and relatively low medical costs.In this study,we examined whether ENPG could be an effective treatment for localized stage I NPC.Methods:Ten newly diagnosed localized stage I NPC patients voluntarily received ENPG alone from June 2007 to September 2017 in Sun Yat-sen University Cancer Center.Simultaneously,the data of 329 stage I NPC patients treated with IMRT were collected and used as a reference cohort.The survival outcomes,quality of life(QOL),and medical costs between two groups were compared.Results:After a median follow-up of 59.0 months(95%CI 53.4-64.6),no death,locoregional recurrence,or distant metastasis was observed in the 10 patients treated with ENPG.The 5-year overall survival,local relapse-free survival,regional relapse-free survival,and distant metastasis-free survival among the ENPG-treated patients was similar to that among the IMRT-treated patients(100%vs.99.1%,100%vs.97.7%,100%vs.99.0%,100%vs.97.4%,respectively,P>0.05).In addition,compared with IMRT,ENPG was associated with decreased total medical costs($4090.42±1502.65 vs.$12620.88±4242.65,P<0.001)and improved QOL scores including dry mouth(3.3±10.5 vs.34.4±25.8,P<0.001)and sticky saliva(3.3±10.5 vs.32.6±23.3,P<0.001).Conclusions:ENPG alone was associated with promising long-term survival outcomes,low medical costs,and satisfactory QOL and might therefore be an alternative strategy for treating newly diagnosed localized stage I NPC patients who refused radiotherapy.However,the application of ENPG should be prudent,and prospective clinical tri-als were needed to further verify the results. | You-Ping Liu Xing Lv Xiong Zou Yi-Jun Hua Rui You Qi Yang Le Xia Shao-Yan Guo Wen Hu Meng-Xia Zhang Si-Yuan Chen Mei Lin Yu-Long Xie Li-Zhi Liu Rui Sun Pei-Yu Huang Wei Fan Xiang Guo Ming-Huang Hong Ming-Yuan Chen | 2019 | Cancer Communications2019，39，1： | 17 |
| 2 | Trend analysis of cancer incidence and mortality in China显示文摘The National Central Cancer Registry of China(NCCRC)updated their nationwide statistics of cancer incidence and mortality in China according to 2013 population-based cancer registration data(due to the time required for data collection,quality control and analysis,the latest cancer statistics available in China have a 3-year lag behind the current year).In this report,the NCCRC provides a comprehensive review of cancer incidence and mortality rates,as well as the statistics overall and by geographical area,cancer sites or age groups(Chen et al.,2017a).It shows that the burden of cancer | Fang Wei Yingfen Wu Le Tang Fang Xiong Can Guo Xiayu Li Ming Zhou Bo Xiang Xiaoling Li Guiyuan Li Wei Xiong Zhaoyang Zeng | 2017 | Science China(Life Sciences)2017，60，11： | 16 |
| 3 | Additive manufacturing of high-strength CrMnFeCoNi high-entropy alloys-based composites with WC addition显示文摘Laser melting deposition with WC addition has been developed to fabricate high-strength CrMnFeCoNibased high-entropy alloys-based composites.By this technique,a microstructure of compact refined equiaxed grains can be achieved,and the tensile strength can be remarkably improved.The sample with 5 wt%WC addition shows a promising mechanical performance with a tensile strength of 800 MPa and an elongation of 37%.The improvement in mechanical property may be attributed to the formation of Cr(23)C6 reinforcement precipitates,which could promote the heterogeneous nucleation of grains and hinder the propagation of slip bands. | Jinfeng Li Shuo Xiang Hengwei Luan Abdukadir Amar Xue Liu Siyuan Lu Yangyang Zeng Guomin Le Xiaoying Wang Fengsheng Qu Chunli Jiang Guannan Yang | 2019 | Journal of Materials Science & Technology2019，35，11： | 13 |
| 4 | Experimental investigation of thermal effect on cavitation characteristics in a liquid rocket engine turbopump inducer显示文摘The objective of this paper is to investigate the effect of water temperature on cavitation characteristics in a turbopump inducer,a series of experiments at different temperatures have been conducted in a newly developed visualization test facility.It is found that higher temperature shows little influence on the non-cavitation performance and breakdown characteristic in the investigated range.The relationship between cavitation development and pressure fluctuation has been discussed in detail.Higher temperature displays a remarkable stabilization effect on the cavitation excited pressure.In particular,the inception cavitation numbers of both the super-synchronous rotating cavitation and synchronous rotating cavitation are decreased at higher temperatures,and the corresponding frequencies are not affected,while the amplitudes are distinctly reduced,and the occurrence range of synchronous rotating cavitation is significantly narrowed.A generalized RayleighPlesset equation has been employed to account for the thermal effect on the bubble development,which may provide a deep insight in understanding the experimental results.Thermal effect is found to act as a remarkable dissipation mechanism to suppress the bubble growth,smooth the collapse.In particular,the excited pressure during collapse is smaller at higher temperatures,which may lead to the stabilization effect of high temperature in this study. | Chunmin WANG Le XIANG Yonghua TAN Hui CHEN Kaifu XU | 2021 | Chinese Journal of Aeronautics2021，34，8： | 7 |
| 5 | A two-stage blade-packing rotating packed bed for intensification of continuous distillation显示文摘A two-stage blade-packing rotating packed bed(TSBP-RPB) was designed and developed for the intensification of continuous distillation. The mass transfer parameters of the TSBP-RPB were investigated using a chemisorption system. Continuous distillation experiments were conducted in the TSBP-RPB by the methanol–water binary system. Experimental results showed that values of the effective interfacial area and liquid-side mass transfer coefficient of the TSBP-RPB were 93–337 m^2·m^(-3) and 0.05–0.19 cm·s^(-1), respectively. The height of equivalent theoretical plate(HETP) of the TSBP-RPB ranged from 1.9 to 10 cm. Moreover, the TSBP-RPB is easy to be manufactured, which shows great potential for the application of continuous distillation. | Yong Luo Guangwen Chu Le Sang Haikui Zou Yang Xiang Jianfeng Chen | 2016 | Chinese Journal of Chemical Engineering2016，24，1： | 6 |
| 6 | Seasonal Variation of δ^13C of Four Tree Species: A Biological Integrator of Environmental Variables显示文摘Foliar δ13C values, an indicator of long-term intercellular carbon dioxide concentration and, thus,of long-term water use efficiency (WUE) in plants, were measured for Pinus massoniana Lamb., P. elliottii Engelm., Cunninghamia laceolata (Lamb.) Hook., and Schima superba Gardn. et Champ. in a restored forest ecosystem in the Jiazhu River Basin. Seasonal variation and the relationship between the foliar δ13Cvalues of the four species and environmental factors (monthly total precipitation, monthly average air temperature, relative humidity, atmospheric pressure, and monthly total solar radiation and evaporation)were investigated. The monthly δ13C values and WUE of the four species increased with increasing precipitation, air temperature, solar radiation, and evaporation, whereas δ13C values of the four species decreased with increasing relative humidity and atmospheric pressure. Despite significant differences in δ13C seasonal means for the four species, our results demonstrate a significant convergence in the responses of δ13C values and WUE to seasonal variations in environmental factors among the species investigated and that the δ13C signature for each species gives a strong indication of environmental variables. | Hai-Tao LI Jun XIA Le XIANG Tao LIANG Qi-Jing LIU | 2005 | Journal of Integrative Plant Biology2005，47，12： | 5 |
| 7 | Three new phenanthrenes from Monomeria barbata Lindl.显示文摘Three new monophenanthrene compounds were isolated from an acetone extract of the tubers of Monomeria barbata Lindl. (Orchidaceae).Using spectroscopic methods,the structures of compounds 1-3 were determined as 1,4,7-trihydroxy-2-methoxy- 9,10-dihydrophenanthrene(1),1-(p-hydroxybenzoyl)-2-methoxy-4,7-dihydroxy-9,10-dihydrophenanthrene(2),1,3,8-tri(p-hydroxybenzyl) -4-methoxy-phenanthrene-4,7-diol(3).These compounds showed cytotoxicities on four tumor cell lines(HepG2, HL-60,Skov-3,A431). | Yang, Ming Hui Cai, Le Li, Mei Hong Zeng, Xiang Hui Yang, Ya Bin Ding, Zhong Tao | 2010 | Chinese Chemical Letters2010，21，3： | 5 |
| 8 | The nucleoprotein of severe fever with thrombocytopenia syndrome virus processes a stable hexameric ring to facilitate RNA encapsidation显示文摘Severe fever with thrombocytopenia syndrome virus(SFTSV),a member of the Phlebovirus genus from the Bunyaviridae family endemic to China,is the causative agent of life-threatening severe fever with thrombocyto-penia syndrome(SFTS),which features high fever and hemorrhage.Similar to other negative-sense RNA viruses,SFTSV encodes a nucleocapsid protein(NP)that is essen-tial for viral replication.NP facilitates viral RNA encapsida-tion and is responsible for the formation of ribonucleopro-tein complex.However,recent studies have indicated that NP from Phlebovirus members behaves in inhomogene-ous oligomerization states.In the present study,we report the crystal structure of SFTSV NP at 2.8Åresolution and demonstrate the mechanism by which it processes a ring-shaped hexameric form to accomplish RNA encapsida-tion.Key residues essential for oligomerization are identi-fi ed through mutational analysis and identifi ed to have a signifi cant impact on RNA binding,which suggests that correct formation of highly ordered oligomers is a criti-cal step in RNA encapsidation.The fi ndings of this work provide new insights into the discovery of new antiviral reagents for Phlebovirus infection. | Honggang Zhou Yuna Sun Ying Wang Min Liu Chao Liu Wenming Wang Xiang Liu Le Li Fei Deng Hualin Wang Yu Guo Zhiyong Lou | 2013 | Protein & Cell2013，4，6： | 4 |
| 9 | Experimental investigation of cavitation instabilities in inducer with different tip clearances显示文摘To investigate the effect of tip clearance size on cavitation characteristics in a turbopump inducer,a series of experiments have been conducted in a newly developed visualization test facility using room temperature water as working fluid.The pressure fluctuations near the tip region were collected,and the cavity structures under various conditions were documented by a high-speed camera.It is found that large tip clearance distinctly reduces both the non-cavitation and cavitation performance.Three cavitation instabilities,super-synchronous rotating cavitation,synchronous rotating cavitation and cavitation surge have been carefully identified through combination of cross-correlation analysis of pressure signals and visualization results.Large tip clearance displays a remarkable stabilization effect on pressure fluctuation,cavitation surge totally disappears,and the range of occurrence of synchronous rotating cavitation becomes smaller for the large tip clearance,whereas super-synchronous rotating cavitation only occurs in the large tip clearance.The cavitation areas are smaller at large tip clearance,while the flow channels are more seriously choked when cavitation occurs heavily in comparison with those at small tip clearance,which may be responsible for the worse cavitation performance. | Le XIANG Yonghua TAN Hui CHEN Kaifu XU | 2021 | Chinese Journal of Aeronautics2021，34，9： | 4 |
| 10 | The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon显示文摘PEGylated liposomes are potential candidates to improve the pharmacokinetic characteristics of encapsulated drugs, to extend their circulation half-life and facilitate their passive accumulation at tumour sites. However, PEG-modified liposomes can induce accelerated blood clearance(ABC) upon repeated administration, and the extent of ABC phenomenon on the cytotoxic drugs-containing PEGylated liposomes is related to the dose of the cytotoxic drugs.In this study, EPI served as a model cytotoxic drug, a hydrophilic surfactant molecule,monosialylganglioside(GM1) was chosen and modified on the liposomes together with PEG.It was shown that upon mixed modification, when GM1 contents reached 10% or 15% mol,the ABC phenomenon of the PEGylated liposomal EPI significantly reduced. We also found that GM1 played an important role in abrogating the ABC phenomenon in both the induction phase and the effectuation phase. The results suggested that GM1 incorporation unfortunately did not avoid occurrence of ABC phenomenon completely, but GM1 modification on PEGylated liposomes may provide a significant improvement in clinical practice of PEGylated liposomes. Further study must be necessary. | Ting Zhang Songlei Zhou Le Kang Xiang Luo Yang Liu Yanzhi Song Xinrong Liu Yihui Deng | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，2： | 3 |
| 11 | Current Alzheimer disease research highlights: evidence for novel risk factors显示文摘Alzheimer disease(AD)is the most common type of dementia characterized by the progressive cognitive and social decline.Clinical drug targets have heavily focused on the amyloid hypothesis,with amyloid beta(Aβ),and tau proteins as key pathophysiologic markers of AD.However,no effective treatment has been developed so far,which prompts researchers to focus on other aspects of AD beyond Aβ,and tau proteins.Additionally,there is a mounting epidemiologic evidence that various environmental factors influence the development of dementia and that dementia etiology is likely heterogenous.In the past decades,new risk factors or potential etiologies have been widely studied.Here,we review several novel epidemiologic and clinical research developments that focus on sleep,hypoxia,diet,gut microbiota,and hearing impairment and their links to AD published in recent years.At the frontiers of AD research,these findings and updates could be worthy of further attention. | Willa D.Brenowitz Yang Xiang Claire T.McEvoy Cui Yang Kristine Yaffe Wei-Dong Le Yue Leng | 2021 | Chinese Medical Journal2021，，18： | 3 |
| 12 | The neuroprotective effects of oxygen therapy in Alzheimer’s disease:a narrative review显示文摘Alzheimer’s disease(AD)is a degenerative neurological disease that primarily affects the elderly.Drug therapy is the main strategy for AD treatment,but current treatments suffer from poor efficacy and a number of side effects.Non-drug therapy is attracting more attention and may be a better strategy for treatment of AD.Hypoxia is one of the important factors that contribute to the pathogenesis of AD.Multiple cellular processes synergistically promote hypoxia,including aging,hypertension,diabetes,hypoxia/obstructive sleep apnea,obesity,and traumatic brain injury.Increasing evidence has shown that hypoxia may affect multiple pathological aspects of AD,such as amyloid-beta metabolism,tau phosphorylation,autophagy,neuroinflammation,oxidative stress,endoplasmic reticulum stress,and mitochondrial and synaptic dysfunction.Treatments targeting hypoxia may delay or mitigate the progression of AD.Numerous studies have shown that oxygen therapy could improve the risk factors and clinical symptoms of AD.Increasing evidence also suggests that oxygen therapy may improve many pathological aspects of AD including amyloid-beta metabolism,tau phosphorylation,neuroinflammation,neuronal apoptosis,oxidative stress,neurotrophic factors,mitochondrial function,cerebral blood volume,and protein synthesis.In this review,we summarized the effects of oxygen therapy on AD pathogenesis and the mechanisms underlying these alterations.We expect that this review can benefit future clinical applications and therapy strategies on oxygen therapy for AD. | Cui Yang Qiu Yang Yang Xiang Xian-Rong Zeng Jun Xiao Wei-Dong Le | 2023 | Neural Regeneration Research2023，18，1： | 3 |
| 13 | Urban spatial expansion and its impact on ecological service values of Chongqing City Proper in the last 30 years显示文摘Based on the remote sensing images of urban land use of Chongqing City Proper in the last 30years(from 1978 to 2011),The paper focuses on the impact of urban spatial expansion on urban ecosystem service.The charactereristics of urban spatial expansion pattern are expressed by Landscape Expansion Index and Index of Fractal Dimension.Taking advantage of calculation of these two indices,changes of the ecological service values in the main urban area of Chongqing caused by the variation of urban expansion patterns are evaluated and the interrelationship is analyzed.The main conclusions and results are as follows;in Chongqing City Proper,the ecological service value decreased rapidly from 1978 to 2011,especially in the period of 2002-2011.Urban spatial expansion pattern has exerted significant impact on urban ecosystem service value.Edge-expansion pattern broke into a great deal of urban enclaves and caused the disadvantage effect of the function of urban ecological system.At the same time,negative correlation existed between the indices of fractal dimension and the ecosystem service value. | 涂建军 Xiang Xinyi Yang Le | 2013 | High Technology Letters2013，19，2： | 3 |
| 14 | Inhibition of metabolic disorders in vivo and in vitro by main constituent of Coreopsis tinctoria显示文摘Objective:To investigate the effects of the ethyl acetate extract of Coreopsis tinctoria(EAEC)on insulin resistance(IR)in rats fed a high-fat diet.Methods:Male Sprague-Dawley(SD)rats were fed a HFD(60%fat)supplemented with EAEC for 8 weeks.The administration of EAEC to the rats with HFD-induced insulin resistance reduced hyperglycemia,plasma levels of insulin,and steatosis in the liver.Metabolomic study was used to analyze the metabolic levels of the high glucose-treated cells,control cells and marein-treated cells.Results:High glucose and high fat conditions caused a significant increase in blood glucose,insulin,serum TC,TG and LDL-C levels,leading to abnormal IR in rats.However,treatment with EAEC protects against HFD-induced IR by improving the fasting serum glucose homeostasis and lipid homeostasis.The high glucose conditions significantly decreased glycogen synthesis and increased PEPCK,G6Pase and Krebs cycle-related enzyme protein levels,leading to an abnormal metabolic state in Hep G2 cells.However,treatment with marein improved IR by increasing glucose uptake and glycogen synthesis and by downregulating PEPCK and G6Pase protein levels.The statistical analysis of the HPLC/MS data demonstrated that marein could restore the normal metabolic state.Conclusion:The results revealed that EAEC ameliorates IR in rats,and marein has the potential to improve IR by ameliorating glucose metabolism disorders. | Bao-ping Jiang Qiu-yue Lv Jia-mei Xiang Liang Le Ke-ping Hu Li-jia Xu Pei-gen Xiao | 2018 | Chinese Herbal Medicines2018，10，2： | 2 |
| 15 | Regulating the d band in WS_(2)@NC hierarchical nanospheres for efficient lithium polysulfide conversion in lithium-sulfur batteries显示文摘The performance of lithium-sulfur batteries is deteriorated by the inferior conductivity of sulfur,the shuttle effect of lithium polysulfides(LiPSs),sluggish redox kinetics of polysulfide intermediates and serious volumetric expansion of sulfur.To overcome these challenges,we report a versatile route to prepare multi-functional nanocomposites with tuable hierarchical structure via ammonium hydroxide(NH_(3)·H_(2) O)induced self-assembly.The versatility of the system has been demonstrated that the organization of the hierarchical structure can be regulated by adding different amounts of NH_(3)·H_(2) O,and WS_(2) and Co_(9)S_(8) with nitrogen-doped carbon coating(denoted as WS_(2)@NC and Co_(9)S_(8)@NC)can be prepared by adding different precursor salts.When the as-prepared materials are applied for Li-S batteries,the WS_(2)@NC composite exhibits a reversible capacity of 1107.4 mAh g^(-1) at 0.1 C after 500 cycles and even 728.9 mAh g^(-1) at2 C for 1000 cycles,which is significantly better than the Co_(9)S_(8) counterpart and other reported WS_(2) sulfur hosts.Experimentally,the advantageous performance of WS_(2) could be attributed to its higher surface area and total pore volume,giving rise to the easier access to electrolyte and better ability to buffer the volume change during the charge/discharge process.Theoretically,the density function theory(DFT)calculation reveals that the as-prepared WS_(2) has a higher binding energy towards LiPSs as well as a lower energy barrier for Li^(+)diffusion on the surface than Co_(9)S_(8).More significantly,the density of states(DOS)analysis further confirms that the superior performance is mainly ascribed to the more prominent shifting and the more charge compensation from d band of W than Co,which increase electronic concentration and give more hybridization of d-p orbitals in the Fermi level of the adsorbed Li2 S4 to accelerate the lithium polysulfide interfacial redox and conversion dynamics in WS_(2).By proposing this mechanism,this work sheds new light on the understanding of catalytic conversion of lithium polysulfides at the atomic level and the strategy to develop advanced cathode materials for high-performance lithium-sulfur batteries. | Jintao Liu Shuhao Xiaoa Le Chang Long Lai Rui Wu Yong Xiang Xingquan Liu Jun Song Chen | 2021 | Journal of Energy Chemistry2021，30，5： | 2 |
| 16 | In Vivo and In Vitro Pharmacological Studies of Methoxycarbonyl-Carboetomidate显示文摘 | Ervin Pejo Joseph F. Cotten Elizabeth W. Kelly Ri Le Ge Gregory D. Cuny Joydev K. Laha Jifeng Liu Xiang Jie Lin Douglas E. Raines | 2012 | Anesthesia & Analgesia2012，，： | 2 |
| 17 | Chromosome-scale assembly of the Kandelia obovata genome显示文摘The mangrove Kandelia obovata(Rhizophoraceae)is an important coastal shelterbelt and landscape tree distributed in tropical and subtropical areas across East Asia and Southeast Asia.Herein,a chromosome-level reference genome of K.obovata based on PacBio,Illumina,and Hi-C data is reported.The high-quality assembled genome size is 177.99 Mb,with a contig N50 value of 5.74 Mb.A large number of contracted gene families and a small number of expanded gene families,as well as a small number of repeated sequences,may account for the small K.obovata genome.We found that K.obovata experienced two whole-genome polyploidization events:one whole-genome duplication shared with other Rhizophoreae and one shared with most eudicots(γevent).We confidently annotated 19,138 protein-coding genes in K.obovata and identified the MADS-box gene class and the RPW8 gene class,which might be related to flowering and resistance to powdery mildew in K.obovata and Rhizophora apiculata,respectively.The reference K.obovata genome described here will be very useful for further molecular elucidation of various traits,the breeding of this coastal shelterbelt species,and evolutionary studies with related taxa. | Min-Jie Hu Wei-Hong Sun Wen-Chieh Tsai Shuang Xiang Xing-Kai Lai De-Qiang Chen Xue-Die Liu Yi-Fan Wang Yi-Xun Le Si-Ming Chen Di-Yang Zhang Xia Yu Wen-Qi Hu Zhuang Zhou Yan-Qiong Chen Shuang-Quan Zou Zhong-Jian Liu | 2020 | Horticulture Research2020，7，1： | 2 |
| 18 | Electrodeposition of Pt-Decorated Ni(OH)_(2)/CeO_(2) Hybrid as Superior Bifunctional Electrocatalyst for Water Splitting显示文摘The facile synthesis of highly active and stable bifunctional electrocatalysts to catalyze water splitting is attractive but challenging.Herein,we report the electrodeposition of Pt-decorated Ni(OH)_(2)/CeO_(2)(PNC)hybrid as an efficient and robust bifunctional electrocatalyst.The graphite-supported PNC catalyst delivers superior hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)activities over the benchmark Pt/C and RuO_(2),respectively.For overall water electrolysis,the PNC hybrid only requires a cell voltage of 1.45V at 10mAcm-2 and sustains over 85 h at 1000mAcm^(-2).The remarkable HER/OER performances are attributed to the superhydrophilicity and multiple effects of PNC,in which Ni(OH)_(2)and CeO_(2)accelerate HER on Pt due to promoted water dissociation and strong electronic interaction,while the electron-pulling Ce cations facilitate the generation of high-valence Ni OER-active species.These results suggest the promising application of PNC for H2 production from water electrolysis. | Huanhuan Liu Zhenhua Yan Xiang Chen Jinhan Li Le Zhang Fangming Liu Guilan Fan Fangyi Cheng | 2020 | Research2020，，1： | 2 |
| 19 | Investigation of Mean Glandular Dose in Diagnostic Mammography in China显示文摘早期胸部肿瘤Ⅹ射线测定法的 420 暴露的调查被执行,参数记录了。入口皮肤空气 kerma (ESAK ) 被测量,吝啬的腺的剂量(MGD ) 根据跳舞的公式是计算的。关联分析证明几个因素能影响 MGD 水平。Mann-whitney 测试和非参量的 ANOVA 分析被用来比较看法类型和 X 光线照相术的系统组织的 MGD 水平。没有重要差别在在 craniocaudal (CC ) 之间的 MGD 被发现组和 mediolateral 倾斜(MLO ) 组。MGD 水平比在另外的二个组在 CR 组是更高的。MGD 断然与压缩的胸厚度(基于计算机的教学) 被相关。MGD 与一半改变了价值层(HVL ) 并且增加了第一然后减少了。在中国的吝啬的 MGD 水平是大约 1.6 mGy 并且是比在国际基本安全标准(IBSS ) 的指导水平低的。 | DU Xiang WANG Jin YANG Chun Yong ZHOU Xian Feng CHEN Wei CAO Xing Jiang ZHOU Yuan Yuan YU Ning Le | 2014 | Biomedical and Environmental Sciences2014，27，5： | 2 |
| 20 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员