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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Corrosion mechanism of micro-arc oxidation treated biocompatible AZ31 magnesium alloy in simulated body fluid显示文摘The rapid degradation of magnesium(Mg) based alloys has prevented their further use in orthopedic trauma fixation and vascular intervention,and therefore it is essential to investigate the corrosion mechanism for improving the corrosion resistance of these alloys. In this work, the effect of applied voltage on the surface morphology and the corrosion behavior of micro-arc oxidation(MAO) with different voltages were carried out to obtain biocompatible ceramic coatings on AZ31 Mg alloy. The effects of applied voltage on the surface morphology and the corrosion behavior of MAO samples in the simulated body fluid(SBF) were studied systematically. Scanning electron microscope(SEM) and X-ray diffractometer(XRD)were employed to characterize the morphologies and phase compositions of coating before and after corrosion. The results showed that corrosion resistance of the MAO coating obtained at 250 V was better than the others in SBF. The dense layer of MAO coating and the corrosion precipitation were the key factors for corrosion behavior. The corrosion of precipitation Mg(OH)2and the calcium phosphate(Ca–P) minerals on the surface of MAO coatings could enhance their corrosion resistance effectively. In addition, the mechanism of MAO coated Mg alloys was proposed. | Ying Li Fang Lu Honglong Li Wenjun Zhu Haobo Pan Guoxin Tan Yonghua Lao Chengyun Ning Guoxin Ni | 2014 | Progress in Natural Science:Materials International2014，24，5： | 7 |
| 3 | Experimental investigation of thermal effect on cavitation characteristics in a liquid rocket engine turbopump inducer显示文摘The objective of this paper is to investigate the effect of water temperature on cavitation characteristics in a turbopump inducer,a series of experiments at different temperatures have been conducted in a newly developed visualization test facility.It is found that higher temperature shows little influence on the non-cavitation performance and breakdown characteristic in the investigated range.The relationship between cavitation development and pressure fluctuation has been discussed in detail.Higher temperature displays a remarkable stabilization effect on the cavitation excited pressure.In particular,the inception cavitation numbers of both the super-synchronous rotating cavitation and synchronous rotating cavitation are decreased at higher temperatures,and the corresponding frequencies are not affected,while the amplitudes are distinctly reduced,and the occurrence range of synchronous rotating cavitation is significantly narrowed.A generalized RayleighPlesset equation has been employed to account for the thermal effect on the bubble development,which may provide a deep insight in understanding the experimental results.Thermal effect is found to act as a remarkable dissipation mechanism to suppress the bubble growth,smooth the collapse.In particular,the excited pressure during collapse is smaller at higher temperatures,which may lead to the stabilization effect of high temperature in this study. | Chunmin WANG Le XIANG Yonghua TAN Hui CHEN Kaifu XU | 2021 | Chinese Journal of Aeronautics2021，34，8： | 7 |
| 4 | Mineralogy of Manganese Oxide Minerals in Iron Manganese Nodules of Several Main Soils in China显示文摘X-ray diffraction and selective chemical dissolution methods were used to investigate the composition of Mn oxide minerals in Fe-Mn nodules of several main types of soils in China. The changes of relative intensity of X-ray diffraction patterns were studied both before and after chemically selective dissolution. It was found that lithiophorite was a common Mn oxide in all examined Fe-Mn nodules. Todorokite, however, was a predominant Mn oxide in Fe-Mn nodules in caf-aquic Vertisols of Linyi, Shandong Province. The Fe-Mn nodules of arp-udic Luvisols in Wuhan and Zaoyang, Hubei Province, contained birnessite and vernadite. Hollandite was found in Fe-Mn nodules of alt-udic Ferrisols of Yizhang, Hunan Province; arp-udic Luvisols of Zaoyang, Hubei Province; and cal-aquic Vertisols of Linyi, Shandong Province. The Fe-Mn nodules in alt-udic Ferrisols of Guiyang, Hunan Province, had a few coronadites. Mineralogy of Mn oxide minerals in soil Fe-Mn nodules was related to soil environment, soil types and quantities of relevant cations. | TAN WENFENG LIU FAN LI YONGHUA HE JIZHENG LI XUEYUAN | 2000 | Pedosphere2000，10，3： | 6 |
| 5 | 中国航天主动力液体火箭发动机技术进展显示文摘Liquid propellant rocket engines for a launch vehicle are an essential aerospace technology, representing the advanced level of hi-tech in a country. In recent years, China’s aerospace industry has made remarkable achievements, and liquid rocket engine technology has also been effectively developed. In this article, the development processes of China’s liquid rocket engines are discussed. Then, the performance features of China’s new generation liquid rocket engines as well as the flight tests of the new-generation launch vehicles are introduced. Finally, the development direction and the most recent progress of the next generation large-thrust liquid rocket engine is presented. | TAN Yonghua ZHAO Jian CHEN Jianhua XU Zhiyu | 2020 | Aerospace China2020，21，2： | 6 |
| 6 | Source apportionment of ambient PM_(10) in urban areas of Wuxi,China显示文摘A total of 168 PM_(10)samples were collected during the year of 2005 at eight sites in the city of Wuxi in China.Fifteen chemical elements,three water-soluble ions,total carbon and organic carbon were analyzed.Six source categories were identified and their contributions to ambient PM_(10)in Wuxi were estimated using a nested chemical mass balance method that reduces the effects of colinearity on the chemical mass balance model.In addition,the concentrations of secondary aerosols,such as secondary organic carbon,sulfate and nitrate,were quantified.The spatially averaged PM_(10)was high in the spring and winter(123μg·m^(-3)and low in the summer-fall(90μg·m^(-3)).According to the result of source apportionment,resuspended dust was the largest contributor to ambient PM_(10),accounting for more than 50%of the PM_(10)mass.Coal combustion(14.6%)and vehicle exhaust(9.4%)were also significant source categories of ambient PM_(10).Construction and cement dust,sulfates,secondary organic carbon,and nitrates made contributions ranging between 4.1%and 4.9%.Other source categories such as steel manufacturing dust and soil dust made low contributions to ambient PM_(10). | Bo HAN Xiaohui BI Yonghua XUE Jianhui WU Tan ZHU Baogui ZHANG Jianqing DING Yuanxin DU | 2011 | Frontiers of Environmental Science & Engineering2011，5，4： | 5 |
| 7 | On tectonic movement in the South China Sea during the Cenozoic显示文摘The tectonic movement taking place at the end of Cretaceous and the beginning of Cenozoic had opened the Cenozoic phase of polycyclic tectonic movements,then the whole crust of the South China Sea had been mainly subjected to the regional stress field of tectonic tension,which was characterized by rifting depression.Seven times of regional tectonic movement and sedimentation had been assembled into a geological development history of polycyclic oscillation.Especially,the tectonic movements were strongly intensified at the end of Cretacious and the beginning of Paleagene,between Late Eocene and Mid-Oligocene,during Mid-and Late Miocene.These three times of tectonic movement had built the most important regional tectonic interfaces in the South China Sea.Crust movements of the South China Sea were the result and epitome of interaction of the Eurasia,Pacific and Indo-Australia plates,that is,they were introduced by polycyclic changes of directions,rates and strengths of lithospheric movements and asthenospheric flows across the Pacific and Indo-Australia plates. | LIN Changsong CHU Fengyou GAO Jinyao TAN Yonghua | 2009 | Acta Oceanologica Sinica2009，28，1： | 4 |
| 8 | Experimental investigation of cavitation instabilities in inducer with different tip clearances显示文摘To investigate the effect of tip clearance size on cavitation characteristics in a turbopump inducer,a series of experiments have been conducted in a newly developed visualization test facility using room temperature water as working fluid.The pressure fluctuations near the tip region were collected,and the cavity structures under various conditions were documented by a high-speed camera.It is found that large tip clearance distinctly reduces both the non-cavitation and cavitation performance.Three cavitation instabilities,super-synchronous rotating cavitation,synchronous rotating cavitation and cavitation surge have been carefully identified through combination of cross-correlation analysis of pressure signals and visualization results.Large tip clearance displays a remarkable stabilization effect on pressure fluctuation,cavitation surge totally disappears,and the range of occurrence of synchronous rotating cavitation becomes smaller for the large tip clearance,whereas super-synchronous rotating cavitation only occurs in the large tip clearance.The cavitation areas are smaller at large tip clearance,while the flow channels are more seriously choked when cavitation occurs heavily in comparison with those at small tip clearance,which may be responsible for the worse cavitation performance. | Le XIANG Yonghua TAN Hui CHEN Kaifu XU | 2021 | Chinese Journal of Aeronautics2021，34，9： | 4 |
| 9 | Effects of magnesium hydroxide on combustion pruducts of polystyrene 显示文摘 | Hu Yonghua Han Xu Tan Rui Li Shufen | 2007 | Chinese Journal of Chemical Physics2007，20，2： | 1 |
| 10 | One step synthesis of azo compounds from nitroaromatics and anilines显示文摘 | Rui Zhao Chunyan Tan Yonghua Xie Chunmei Gao Hongxia Liu Yuyang Jiang | 2011 | Tetrahedron Letters2011，，29： | 1 |
| 11 | Continuous versus interrupted suture techniques of pancreaticojejunostomy after pancreaticoduodenectomy显示文摘 | Yonghua Chen Nengwen Ke Chunlu Tan Hao Zhang Xing Wang Gang Mai Xubao Liu | 2014 | Journal of Surgical Research2014，，： | 1 |
| 12 | 显示文摘 | Tan Xiaoming Huang Naiyu Shang Yonghua | 2001 | Journal Huazhong University of Sci &Tech2001，29，8： | 1 |
| 13 | 显示文摘 | Tan Xiaoming Zhao Chunlin Shang Yonghua | 2002 | Foundry2002，51，40： | 1 |
| 14 | Syntheses and Anti-cancer Activities of Glycosylated Derivatives of Diosgenin显示文摘 | TAN Yonghua XIAO Xiao YAO Jianing HAN Fei LOU Huayong LUO Heng LIANG Guangyi BEN-DAVID Yaacov PAN Weidong | 2017 | Chemical Research in Chinese Universities2017，33，1： | 1 |
| 15 | Effects of magnesium hydroxide on combustion products of polystyrene显示文摘 | Yonghua Hu Xu Han Rui Tan | 2007 | Chinese Journal of Chemical Physics2007，20，： | 1 |
| 16 | SCGN deficiency is a risk factor for autism spectrum disorder显示文摘Autism spectrum disorder(ASD)affects 1-2%of all children and poses a great social and economic challenge for the globe.As a highly heterogeneous neurodevelopmental disorder,the development of its treatment is extremely challenging.Multiple pathways have been linked to the pathogenesis of ASD,including signaling involved in synaptic function,oxytocinergic activities,immune homeostasis,chromatin modifications,and mitochondrial functions.Here,we identify secretagogin(SCGN),a regulator of synaptic transmission,as a new risk gene for ASD.Two heterozygous loss-of-function mutations in SCGN are presented in ASD probands.Deletion of Scgn in zebrafish or mice leads to autism-like behaviors and impairs brain development.Mechanistically,Scgn deficiency disrupts the oxytocin signaling and abnormally activates inflammation in both animal models.Both ASD probands carrying Scgn mutations also show reduced oxytocin levels.Importantly,we demonstrate that the administration of oxytocin and anti-inflammatory drugs can attenuate ASD-associated defects caused by SCGN deficiency.Altogether,we identify a convergence between a potential autism genetic risk factor SCGN,and the pathological deregulation in oxytocinergic signaling and immune responses,providing potential treatment for ASD patients suffering from SCGN deficiency.Our study also indicates that it is critical to identify and stratify ASD patient populations based on their disease mechanisms,which could greatly enhance therapeutic success. | Zhe Liu Shuai Tan Lianyu Zhou Li Chen Mingfeng Liu Wang Wang Yingying Tang Qin Yang Sensen Chi Peiyan Jiang Yue Zhang Yonghua Cui Junhong Qin Xiao Hu Shenglong Li Qi Liu Lu Chen Song Li Ezra Burstein Wei Li Xiaohu Zhang Xianming Mo Da Jia | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 0 |
| 17 | Alternative Splicing of OsCYL4 Controls Drought Resistance via Regulating Water Loss and Reactive Oxygen Species-Scavenging in Rice显示文摘A rice cyclase gene,OsCYL4b,identified as an alternative splice variant of the cyclase gene OsCYL4a,is involved in the regulation of drought stress and oxidative response.Compared with OsCYL4a,OsCYL4b lacks the second exon,which is located in the conserved motif 3,and may be a functionally important site.Our results suggested that OsCYL4b was responsive to multiple abiotic stresses,and was localized to both the cytoplasm and plasma membrane.The overexpression of OsCYL4b resulted in significantly enhanced drought and osmotic stress tolerance,reduced water loss,and increased abscisic acid(ABA)content compared with the wild type(WT). | SHA Gan SHEN Xin WU Zini XU Xiaocan XU Xin TAN Yanping LIU Xinqiong TANG Xianyin WANG Chuntai QIN Yonghua | 2024 | Rice science2024，31，1： | 0 |
| 18 | erbB4/HER4在非小细胞NSCLC中的表达研究(英文)显示文摘Objective: To test the expression of HER4 in non-small cell lung cancer (NSCLC) and elucidate the relationship between its over-expression and the clinical pathology of NSCLC. Methods: 70 cases of paraffin-embedded tissues from informative NSCLC were tested for the expression of HER4 by means of immunohistochemical assay. Results: HER4 were overexpressed in NSCLC in 91.4%. The overexpression of HER4 correlated only with the lymph node metastasis, TNM staging and survival after operation. Conclusion: ErbB4 is one of the genes to regulate the growth of NSCLC in advanced stages and artificial interference of the overexpression of HER4 in NSCLC might be a good way for the treatment of NSCLC in advanced stages. | Zaichun Deng Wenying Yu Guoping Hu Ruheng Zheng Dunhua Zhang Yunshan Tan Yonghua Xu Wanli Jiang | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，2： | 0 |
| 19 | Evaluation of Medicinal Plant Extracts for Rice Blast Disease Control显示文摘The potential of medicinal plant extracts to control rice blast fungus Magnaporthe oryzae was investigated. We screened 48 extracts prepared from 8 medicinal plant species and identified 20 extracts with ≥ 10% inhibitory activity against M. oryzae. Among them, ethanol extract of Paris polyphylla, ethyl acetate extract of Phellodendron chinense, and n-butanol extract of Menispermum dauricum plants exhibited 100%, 70% and 50% inhibition of M. | TAN Yanping DENG Shiqi QIN Yonghua XU Xin YU You CUI Liu WANG Chuntai JIANG Changjie LIU Xinqiong | 2023 | Rice science2023，30，1： | 0 |
| 20 | 3D-printed tissue repair patch combining mechanical support and magnetism for controlled skeletal muscle regeneration显示文摘Physical forces,such as magnetic and mechanical stimulation,are known to play a significant role in the regulation of cell response.In the present study,a biomimetic regeneration patch was fabricated using E-jet 3 D printing,which integrates mechanical and magnetic stimulation in a biocompatible'one-pot reaction'strategy when combined with a static magnetic field(SMF).The magneto-based therapeutic regeneration patch induced myoblasts to form aligned and multinucleated myotubes,regulated the expression of myogenic-related genes,and activated the p38αmitogen-activated protein kinase pathway via the initiation of myogenic differentiation.To validate the efficiency of the proposed strategy,the regeneration patch was implanted into mice and exposed to a suitable SMF,which resulted in significantly enhanced in vivo skeletal muscle regeneration.The findings demonstrated that appropriate external physical stimulation provides a suitable biophysical microenvironment that is conducive to tissue regeneration.The method used in the present study represents a promising technique to induce the regeneration of damaged skeletal muscle tis sue. | Xiaocheng Wang Ruibo Zhao Jian Wang Xinghuan Li Lijuan Jin Wenyu Liu Lifang Yang Yonghua Zhu Zhikai Tan | 2022 | Bio-Design and Manufacturing2022，5，2： | 0 |
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