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| 1 | Prevalence of fatty liver disease and its risk factors in the population of South China显示文摘AIM: To investigate the population-based prevalence of fatty liver disease (FLD) and its risk factors in Guangdong Province,China. METHODS: A cross-sectional survey with multiple-stage stratified cluster and random sampling of inhabitants over 7-year-old was performed in 6 urban and rural areas of Guangdong Province,China. Questionnaires,designed by co-working of epidemiologists and hepatologists,included demographic characteristics,current medication use,medical history and health-relevant behaviors,i.e. alcohol consumption,smoking habits,dietary habits and physical activities. Anthropometric measurements,biochemical tests and abdominal ultrasonography were carried out. RESULTS: Among the 3543 subjects,609 (17.2%) were diagnosed having FLD (18.0% males,16.7% females,P > 0.05). Among them,the prevalence of confirmed alcoholic liver disease (ALD),suspected ALD and nonalcoholic fatty liver disease (NAFLD) were 0.4%,1.8%,and 15.0%,respectively. The prevalence rate (23.0%) was significantly higher in urban areas than (12.9%) in rural areas. After adjustment for age,gender and residency,the standardized prevalence of FLD in adults was 14.5%. Among them,confirmed ALD,suspected ALD and NAFLD were 0.5%,2.3%,and 11.7%,respectively,in adults and 1.3% (all NAFLD) in children at the age of 7-18 years. The overall prevalence of FLD increased with age in both genders to the peak of 27.4% in the group of subjects at the age of 60-70 years. The prevalence rate was significantly higher in men than in women under the age of 50 years (22.4% vs 7.1%,P < 0.001). However,the opposite phenomenon was found over the age of 50 years (20.6% vs 27.6%,P < 0.05). Multivariate and logistic regression analysis indicated that male gender,urban residency,low education,high blood pressure,body mass index,waist circumference,waist to hip ratio,serum triglyceride and glucose levels were the risk factors for FLD. CONCLUSION: FLD,especially NAFLD,is prevalent in South China. There are many risk factors for FLD. | Yong-Jian Zhou Yu-Yuan Li Yu-Qiang Nie Jin-Xiang Ma Lun-Gen Lu Sheng-Li Shi Min-Hu Chen Pin-Jin Hu | 2007 | World Journal of Gastroenterology2007，13，47： | 111 |
| 2 | Characterization and assessment of volatile organic compounds (VOCs) emissions from typical industries显示文摘VOCs play an increasingly important role in affecting air quality and threatening human health in China in recent years,where industry activities show a significant contribution to VOCs emission.In this article we report our long term study of industrial VOCs emissions of six major industries (vehicle manufacturing,printing,equipment coating,electronic manufacturing,furniture manufacturing and bio-pharming) on the aspects of emission characteristics,environmental impact and health risk assessment,and control challenge analysis with the purpose to obtain in-depth understanding of industry VOCs emissions and offer some original basements for national control and management of industry VOCs emissions.This study shows that all these industries give middle or low emission with total VOCs concentration less than 1000 mg/m3 at each exhaust pipe.Benzenes,esters,alcohols,ketones,alkanes,chloroalkanes and alkenes were detected as the major emission components and the most frequently monitored VOCs were benzenes,which varied obviously with different processes and industries.The environmental impact assessments indicate that vehicle manufacturing and benzenes should be prior controlled with the purpose to reduce air pollution.While,health risk assessments suggest that furniture manufacturing and chloroalkanes should be firstly controlled.Control analysis indicates that developing technologies with low cost and high efficiency and establishing and completing specific industry emission standards/regulations are the two key issues in VOCs emission management at present stage. | WANG HaiLin NIE Lie LI Jing WANG YuFei WANG Gang WANG JunHui HAO ZhengPing | 2013 | Science China(Technological Sciences)2013，56，3： | 60 |
| 3 | Berberine ameliorates renal injury in streptozotocin-induced diabetic rats by suppression of both oxidative stress and aldose reductase显示文摘背景 Berberine 是 Coptidis 根茎(CR ) 和外皮 phellodendri 的主要成分之一,在这研究,我们与糖尿病的 nephropathy (DN ) 在老鼠在肾的功能和它的可能的机制上调查了 berberine 的有益的效果。方法男 Wistar 老鼠被划分成三个组:正常,糖尿病的模型,和 berberine 处理组。在糖尿病的模型和 berberine 治疗组的老鼠被 intraperitonal 注射与 streptozotocin (STZ ) 导致到糖尿病。Glomerular 区域, glomerular 体积, fasting 血葡萄糖(FBG ) ,血脲氮(甜面包) ,浆液 creatinine (Cr ) 和为 24 个小时(UP24h ) 的尿蛋白质用商业地可得到的工具包被测量。同时, superoxide dismutase (草皮) 的活动,在浆液的 malondialdehyde (MDA ) 的内容, aldose reductase (AR ) 的活动和在肾的 AR mRNA 和蛋白质的表示被不同方法检测。结果显示出的结果 berberine 的那个口头的政府(200mg 牲汥瑡摥 ? ぐ?? | LIU Wei-hua HEI Zi-qing NIE Hong TANG Fu-tian HUANG He-qing LI Xue-juan DENG Yan-hui CHEN Shao-rui GUO Fen-fen HUANG Wen-ge CHEN Feng-ying LIU Pei-qing | 2008 | Chinese Medical Journal2008，，8： | 41 |
| 4 | CRISPR-Cas12a has both cis- and trans-cleavage activities on single-stranded DNA显示文摘 | Shi-Yuan Li Qiu-Xiang Cheng Jia-Kun Liu Xiao-Qun Nie Guo-Ping Zhao Jin Wang | 2018 | Cell Research2018，28，4： | 41 |
| 5 | Enhanced secondary pollution offset reduction of primary emissions during COVID-19 lockdown in China显示文摘To control the spread of the 2019 novel coronavirus(COVID-19),China imposed nationwide restrictions on the movement of its population(lockdown)after the Chinese New Year of 2020,leading to large reductions in economic activities and associated emissions.Despite such large decreases in primary pollution,there were nonetheless several periods of heavy haze pollution in eastern China,raising questions about the well-established relationship between human activities and air quality.Here,using comprehensive measurements and modeling,we show that the haze during the COVID lockdown was driven by enhancements of secondary pollution.In particular,large decreases in NOx emissions from transportation increased ozone and nighttime NO_(3)radical formation,and these increases in atmospheric oxidizing capacity in turn facilitated the formation of secondary particulate matter.Our results,afforded by the tragic natural experiment of the COVID-19 pandemic,indicate that haze mitigation depends upon a coordinated and balanced strategy for controlling multiple pollutants. | Xin Huang Aijun Ding Jian Gao Bo Zheng Derong Zhou Ximeng Qi Rong Tang Jiaping Wang Chuanhua Ren Wei Nie Xuguang Chi Zheng Xu Liangduo Chen Yuanyuan Li Fei Che Nini Pang Haikun Wang Dan Tong Wei Qin Wei Cheng Weijing Liu Qingyan Fu Baoxian Liu Fahe Chai Steven JDavis Qiang Zhang Kebin He | 2021 | National Science Review2021，8，2： | 47 |
| 6 | A comprehensive classification method for VOC emission sources to tackle air pollution based on VOC species reactivity and emission amounts显示文摘In China, volatile organic compound(VOC) control directives have been continuously released and implemented for important sources and regions to tackle air pollution. The corresponding control requirements were based on VOC emission amounts(EA), but never considered the significant differentiation of VOC species in terms of atmospheric chemical reactivity. This will adversely influence the effect of VOC reduction on air quality improvement. Therefore,this study attempted to develop a comprehensive classification method for typical VOC sources in the Beijing–Tianjin–Hebei region(BTH), by combining the VOC emission amounts with the chemical reactivities of VOC species. Firstly, we obtained the VOC chemical profiles by measuring 5 key sources in the BTH region and referencing another 10 key sources, and estimated the ozone formation potential(OFP) per ton VOC emission for these sources by using the maximum incremental reactivity(MIR) index as the characteristic of source reactivity(SR). Then, we applied the data normalization method to respectively convert EA and SR to normalized EA(NEA) and normalized SR(NSR) for various sources in the BTH region.Finally, the control index(CI) was calculated, and these sources were further classified into four grades based on the normalized CI(NCI). The study results showed that in the BTH region,furniture coating, automobile coating, and road vehicles are characterized by high NCI and need to be given more attention; however, the petro-chemical industry, which was designated as an important control source by air quality managers, has a lower NCI. | Guohao Li Wei Wei Xia Shao Lei Nie Hailin Wang Xiao Yan Rui Zhang | 2018 | Journal of Environmental Sciences2018，30，5： | 32 |
| 7 | Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation显示文摘As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation(FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation(STC), we conducted a singlecenter, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber(pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber(pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0%(20/29) and 75.9%(22/29), respectively. At the end of the study,48.3%(14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6%(17/29)of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with soluble dietary fiber(pectin) had both short-term and long-term efficacy in treating STC. | Xueying Zhang Hongliang Tian Lili Gu Yongzhan Nie Chao Ding Xiaolong Ge Bo Yang Jianfeng Gong Ning Li | 2018 | Science China(Life Sciences)2018，61，7： | 33 |
| 8 | Oral health status in Sichuan Province: findings from the oral health survey of Sichuan, 2015–2016显示文摘To investigate oral health status in the residents of Sichuan Province, southwest China, a cross-sectional study was performed using the latest Oral Health Survey Basic Methods recommended by the World Health Organization. A multistage stratified random cluster-sampling method was used to enroll participants from the following three groups: children aged 3–5 years,adolescents aged 12 years, and people aged 65–74 years. In these three groups, the mean numbers of teeth that were affected by caries were 3.28, 0.86 and 5.13, respectively, resulting in a prevalence of 63.47%, 37.20% and 83.20%, respectively.Relative to the high rate of decayed teeth, the prevalence of fillings was very low in all age groups(0.97%, 7.24% and 5.43%,respectively). In the 12-year-old adolescent group, only 3.61% had good pit and fissure sealing. In addition, the rate of dental fluorosis was 24.80%, and the Community Fluorosis Index value was 0.39. In the elder group, the community periodontal index was2.92. The prevalence in the elderly of having lost at least one tooth was 75.54%. Additionally, 4.44% of these participants were edentulous. The incidence of dental prosthesis was 51.75%, the proportion with a removable partial denture, a fixed denture, full dentures, dental implants and an informal fixed bridge was 21.59%, 11.45%, 4.64%, 0 and 16.67%, respectively. In this study,8.2% of the elderly participants were affected by different types of oral mucosal lesions. Among such lesions, recurrent aphthous ulcers were most prevalent(2.69%) and oral lichen planuses were second(1.6%). The conclusion presented in this survey is that oral diseases, especially dental caries and periodontal disease, are frequent and common in Sichuan province, China. Moreover, the treatment rate is very low, and primary prevention and treatment options are therefore urgently needed in this population. | Wei Yin Ying-Ming Yang Hong Chen Xue Li Zhuo Wang Li Cheng Qiu-Dan Yin Hong-Zhi Fang Wei Fei Fang-Lin Mi Min-Hai Nie Tao Hu Xue-Dong Zhou | 2017 | International Journal of Oral Science2017，9，1： | 30 |
| 9 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers显示文摘象 5-methylcytosine (5mC ) 和 5-hydroxymethylcytosine (5hmC ) 那样的 DNA 修正是知道在哺乳动物影响全球基因表示的 epigenetic 标记。在人的染色体,与基因表示的靠近的关联和高化学的稳定性给他们的流行,这些 DNA epigenetic 标记能为癌症用作理想的 biomarkers 诊断。利用一种高度敏感、选择的化学标记技术,我们这里报导在传播没有房间的 DNA ( cfDNA )并且在从最近与 colorectal 诊断的 260 个病人的一个队收集的配对的肿瘤和邻近的纸巾的 genomic DNA ( gDNA )的 5hmC 的染色体宽的介绍,胃,胰腺,从 90 个健康个人的肝或甲状腺癌症和正常纸巾。5hmC 主要在与开的染色质和容许的 histone 修正重合的 transcriptionally 活跃的区域被散布。柔韧的联系癌症的 5hmC 签名在 cfDNA 被识别为特定的癌症类型是特征的。传播 cfDNA 的 5hmC 底 biomarkers colorectal 和胃的癌症是高度预兆的并且比常规 biomarkers 优异并且比得上从织物活体检视的 5hmC biomarkers。因此,这新策略能从血样品的分析为癌症的诊断和预后导致有效、最低限度地侵略的方法的发展。 | Wenshuai Li Xu Zhang Xingyu Lu Lei You Yanqun Song Zhongguang Luo Jun Zhang Ji Nie Wanwei Zheng Diannan Xu Yaping Wang Yuanqiang Dong Shulin Yu Jun Hong Jianping Shi Hankun Hao Fen Luo Luchun Hua Peng Wang Xiaoping Qian Fang Yuan Lianhuan Wei Ming Cui Taiping Zhang Quan Liao Menghua Dai Ziwen Liu Ge Chen Katherine Meckel Sarbani Adhikari Guifang Jia Marc B Bissonnette Xinxiang Zhang Yupei Zhao Wei Zhang Chuan He Jie Liu | 2017 | Cell Research2017，27，10： | 30 |
| 10 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 11 | Quercetin induces apoptosis by activating caspase-3 and regulating Bcl-2 and cyclooxygenase-2 pathways in human HL-60 cells显示文摘橡黄素是自然地发生之一饮食的黄酮醇混合物。它在植物富有地是在场的并且有 chemopreventive 和 anticancer 效果。调查它的 anticancer 机制,我们对尖锐白血病房间线检验了橡黄素的活动, HL-60。我们的结果证明橡黄素禁止了房间增长并且在一个时间依赖者和剂量依赖者举止导致了 apoptosis。而且,橡黄素下面调整 anti-apoptosis 蛋白质 Bcl-2 的表示并且起来调整 pro-apoptosis 蛋白质 Bax 的表示。Caspase-3 被橡黄素也激活,它开始了一条 caspase-3-depended mitochodrial 小径导致 apoptosis。橡黄素禁止了 cycloocygenase-2 (Cox-2 ) 的表示,这也被发现 mRNA 和 Cox-2 蛋白质。一起拿,这些调查结果建议橡黄素由禁止 Cox-2 表示在一条 caspase-3-dependent 小径导致 apoptosis 并且调整下游的 apoptotic 部件的表示,包括 Bcl-2 和 Bax。橡黄素能是可能安全地在白血病治疗被使用的一个有势力和有希望的药。 | Guomin Niu Songmei Yin Shuangfeng Xie Yiqing Li Danian Nie Liping Ma Xiuju Wang Yudan Wu | 2011 | Acta Biochimica et Biophysica Sinica2011，43，1： | 28 |
| 12 | Homology-mediated end joining-based targeted integration using CRISPR/Cas9显示文摘 | Yao, Xuan Wang, Xing Hu, Xinde Liu, Zhen Liu, Junlai Zhou, Haibo Shen, Xiaowen Wei, Yu Huang, Zijian Ying, Wenqin Wang, Yan Nie, Yan-Hong Zhang, Chen-Chen Li, Sanlan Cheng, Leping Wang, Qifang Wu, Yan Huang, Pengyu Sun, Qiang Shi, Linyu Yang, Hui | 2017 | Cell Research2017，27，6： | 28 |
| 13 | Performance of the Seasonal Forecasting of the Asian Summer Monsoon by BCC_CSM1.1(m)显示文摘This paper provides a comprehensive assessment of Asian summer monsoon prediction skill as a function of lead time and its relationship to sea surface temperature prediction using the seasonal hindcasts of the Beijing Climate Center Climate System Model, BCC CSM1.1(m). For the South and Southeast Asian summer monsoon, reasonable skill is found in the model's forecasting of certain aspects of monsoon climatology and spatiotemporal variability. Nevertheless, deficiencies such as significant forecast errors over the tropical western North Pacific and the eastern equatorial Indian Ocean are also found. In particular, overestimation of the connections of some dynamical monsoon indices with large-scale circulation and precipitation patterns exists in most ensemble mean forecasts, even for short lead-time forecasts.Variations of SST, measured by the first mode over the tropical Pacific and Indian oceans, as well as the spatiotemporal features over the Ni no3.4 region, are overall well predicted. However, this does not necessarily translate into successful forecasts of the Asian summer monsoon by the model. Diagnostics of the relationships between monsoon and SST show that difficulties in predicting the South Asian monsoon can be mainly attributed to the limited regional response of monsoon in observations but the extensive and exaggerated response in predictions due partially to the application of ensemble average forecasting methods. In contrast, in spite of a similar deficiency, the Southeast Asian monsoon can still be forecasted reasonably, probably because of its closer relationship with large-scale circulation patterns and El Nino–Southern Oscillation. | LIU Xiangwen WU Tongwen YANG Song JIE Weihua NIE Suping LI Qiaoping CHENG Yanjie LIANG Xiaoyun | 2015 | Advances in Atmospheric Sciences2015，32，8： | 25 |
| 14 | Fast track clinical pathway implications in esophagogastrectomy显示文摘AIM:To investigate the feasibility of fast track clinical pathway for esophageal tumor resections. METHODS:One hundred and fourteen patients with esophageal carcinoma who underwent esophagogastrectomy from January 2006 to October 2007 in our department were studied.Fast track clinical pathway included analgesia control,fluid infusion volume control,early ambulation and enteral nutrition. Nasogastric tube was removed 3 d after operation and chest tube was removed 4 d after operation as a routine,and full liquid diet 5 d after operation. RESULTS:Among 114 patients(84 men and 30 women),26 patients underwent fast track surgery,including 17 patients over 65 years old and 9 under 65(P=0.014);18 patients who had preoperative complications could not bear fast track surgery(P< 0.001).No significant differences in tolerance of fast track surgery were attributed to differences in gender,differentiated degree or stage of tumor,pathological type of tumor,or operative incision.The median length of hospital stay was 7 d(5-28 d),4%patients were readmitted to hospital within 30 d of discharge.Three patients died and postoperative mortality was 2.6%. All 3 patients had no determinacy to fast track surgery approach.CONCLUSION:The majority of patients with esophageal carcinoma can tolerate fast track surgery. Patients younger than 65 or who have no preoperative diseases have the best results.Median length of hospital stay has been reduced to 7 d. | Ke Jiang Lin Cheng Jian-Jun Wang Jin-Song Li Jun Nie | 2009 | World Journal of Gastroenterology2009，15，4： | 24 |
| 15 | Behavior of composite rigid frame bridge under bi-directional seismic excitations显示文摘Pushover analysis and time history analysis are conducted to explore the bi-directional seismic behavior of composite steel-concrete rigid frame bridge,which is composed of RC piers and steel-concrete composite girders.Both longitudinal and transverse directions excitations are investigated using OpenSees.Firstly,the applicability of pushover analysis based on the fundamental mode is discussed.Secondly,an improved pushover analysis method considering the contribution of higher modes is proposed,and the applicability on composite rigid frame bridges under bi-directional earthquake is verified.Based on this method,an approach to predict the displacement responses of composite rigid frame bridge under random bi-directional seismic excitations by revising the elasto-plastic demand curve is also proposed.It is observed that the developed method yield a good estimate on the responses of composite rigid frame bridges under bi-directional seismic excitations. | Xiaogang Liu Jiansheng Fan Jianguo Nie Guo Li | 2014 | Journal of Traffic and Transportation Engineering(English Edition)2014，1，1： | 22 |
| 16 | Long-term propagation of tree shrew spermatogonial stem cells in culture and successful generation of transgenic offspring显示文摘树鼯有一种靠近的关系到首领并且在生物医学的研究比啮齿类动物有许多优点。然而,基因操作方法的缺乏妨碍了这个动物的更宽的使用。Spermatogonial 干细胞(SSC ) 成功地在文化被扩展了允许复杂基因在老鼠和老鼠编辑。这里,没有干细胞性质的损失,我们为树鼯 SSC 的长期的扩大描述一个文化系统。在我们的学习,胸腺房间抗原 1 被用来充实树鼯 SSC。定序 RNA 分析表明表明小径的 Wnt/-catenin 在无差别的 SSC 是活跃的,但是是在 SSC 区别的开始之上的 downregulated。树鼯的暴露到 recombinant Wnt3a 蛋白质的主要 SSC 在文化的起始的段落期间提高了 SSC 的幸存。当 feeder 被发现为树鼯 SSC 增长必要,树鼯 Sertoli 房间,然而并非老鼠使用胚胎的成纤维细胞,导致柔韧的房间扩大和长期的文化。扩展的树鼯 SSC 是有提高的绿色的 transfected 荧光灯表示 lentiviral 向量的蛋白质(EGFP ) 。在进消毒的成年的男树鼯睾丸的移植以后,标注 EGFP 的 SSC 能恢复精子发生并且成功地产生转基因的后代。而且,这些 SSC 对 CRISPR/Cas9-mediated 基因修正合适。在有编辑的基因的联合的树鼯 SSC 接近膨胀的一个文化系统的发展用树鼯为精确染色体操作铺平道路。 | Chao-Hui Li Lan-Zhen Yan Wen-Zan Ban Qiu TH Yong Wu Lin Wang Rui Bi Shuang Ji Yu-Hua Ma Wen-Hui Nie Long-Bao Lv Yong-Gang Yao Xu-Dong Zhao Ping Zheng | 2017 | Cell Research2017，27，2： | 22 |
| 17 | Stage-progressive distribution pattern of the Lungmachi black graptolitic shales from Guizhou to Chongqing, Central China显示文摘The Lungmachi Formation is widely distributed in Guizhou, Chongqing and the adjacent area. It is important for the study of Silurian biostratigraphy and shale-gas investigation. Based on those biostratigraphically well-studied sections from Guiyang to Huayingshan, we reveal the stage-progressive distribution pattern of the Lungmachi black shales. The distribution of the Lungmachi black shales in the studying area can be subdivided into four geographic belts from the south to the north,reflecting the joint effect of regional and global environmental changes. The graptolite depth zonation model was adopted herein to infer the water depth of major graptolite assemblages from the black shales. The changes in the water depth indicate two major stages. The first stage is named the transgressive distribution stage which ranged from the Persculptograptus persculptus Biozone(LM1, upper Hirnantian) to the Coronograptus cyphus Biozone(LM5, upper Rhuddanian), an interval mostly controlled by global sea-level rise. The second stage, ranging from the Demirastrites triangulatus Biozone(LM6, lower Aeronian) to the Spirograptus guerichi Biozone(LM9, lower Telychian), is named the regressive shrinking stage, during which the black shales were gradually replaced by mixed-facies or carbonate sediments from the south to the north, representing the effects of the persistent uplifting of the Central Guizhou Oldland. | CHEN Xu FAN JunXuan WANG WenHui WANG HongYan NIE HaiKuan SHI XueWen WEN ZhiDong CHEN DongYang LI WenJie | 2017 | Science China Earth Sciences2017，60，6： | 23 |
| 18 | Mapping and Quantitative Trait Loci Analysis of Verticillium Wilt Resistance Genes in Cotton显示文摘Verticillium wilt is one of the most serious constraints to cotton production in almost all of the cotton-growing countries. In this study, 'XinLuZao1' (XLZ1), a susceptible cultivar Gossypium hirsutum L. and 'Hai7124' (H7124), a resistant line G. barbadense, and their F2:3 families were used to map and study the disease index induced by verticillium wilt. A total of 430 SSR loci were mapped into 41 linkage groups; the map spanned 3 745.9 cM and the average distance between adjacent loci was 8.71 cM. Four and five quantitative trait loci (QTLs) were detected based on the disease index investigated on July 22 and August 24 in 2004, respectively. These nine QTLs explained 10.63?28.83% of the phenotypic variance, six of them were located on the D sub-genome. Two QTLs located in the same marker intervals may partly explain the significant correlation of the two traits. QTLs explaining large phenotypic variation were identified in this study, which may be quite useful in cotton anti-disease breeding. | Hong-Mei Wang Zhong-Xu Lin Xian-Long Zhang Wei Chen Xiao-Ping Guo Yi-Chun Nie Yun-Hai Li | 2008 | Journal of Integrative Plant Biology2008，50，2： | 21 |
| 19 | Clinical study of arterial anatomic variations for transradial coronary procedure in Chinese population显示文摘光线的动脉当前是的背景为冠的干预过程认为是一条有用途径。光线的动脉的足够的解剖信息应该在执行 transradial 是有用的冠的过程。关于中国人口的很少数据在这个领域里被获得了。因此,我们试着在 3000 个盒子,光线的动脉和 subclavical 的一件估计的样品评估发生和异常模式,和他们对干预 procedure.Methods 的影响的临床的意义动脉 angiography 在鞘和冠的 angiography (CA ) 的插入以后被执行。包括分支异例,光线的动脉的扭曲和程序的特征的可评估的数据被分析。过程成功被定义为 CA 或没有在这研究改变到另外的 routes.Results ,与起始的光线的动脉途径完成的经皮的冠的干预(一种总线标准), CA 的 1897 个盒子被承担,与一种总线标准相结合的 CA 的 1103 个盒子是 transradial 干预( TRI )的 performed.The 成功率是96.6%( 2899/3000 )。在 44 种情况中的途径被改变到 contralateral 光线的动脉和 57 个盒子与起始的光线的动脉途径由于失败被改变到臂的动脉或大腿骨的动脉。上面的手足动脉的 angiography 在所有情况中被执行。上面的手足动脉的解剖变化在 610 个病人(20.3%)被注意,它包括了光线的动脉(5.0%)的曲折配置,发育不全(2.2%),桡尺骨的循环(1.1%),光线的动脉(7.7%)的反常起源,光线的动脉(1.4%)的狭窄,臂的动脉(0.9%)的一种曲折配置,一锁骨下的动脉(1.9%)的曲折配置, lusoria 锁骨下的动脉(0.1%),和锁骨下的动脉吸藏(0.03%)。在正常人口的程序的成功率比在变化组高(97.6% 对 93.0% , P < 0.001 ) 。另外,除了光线的动脉吸藏的复杂并发症的另外的程序的结果和发生比光线的动脉的解剖变化是的变化 group.Conclusions 也显著地优异普通,在 trans 光线的途径完成重要限制。适当仪器和理解的一些技巧的选择是有用的克服障碍并且有效地减少学习曲线。 | NIE Bin ZHOU Yu-jie LI Guo-zhong SHI Dong-mei WANG Jian-long | 2009 | Chinese Medical Journal2009，，18： | 21 |
| 20 | Association between Vitamin D Insufficiency and the Risk for Gestational Diabetes Mellitus in Pregnant Chinese Women显示文摘Objective To investigate the association between vitamin D deficiency and risk of gestational diabetes mellitus(GDM) in pregnant Chinese women.Methods A nested case-control study was conducted.Clinical and biochemical data were analyzed for 200 subjects with GDM and 200 subjects with normal glucose tolerance(NGT).Results The median(interquartile range) serum 25-hydroxyvitamin D(25OHD) levels were 22.39(17.67,29.38) and 25.86(19.09,34.88) nmol/L in the GDM and NGT groups,respectively.Rates of 25OHD deficiency or insufficiency were significantly higher in the GDM group than in the NGT group.Subjects with 25OHD levels <25 nmol/L had a 1.8-fold higher risk of GDM compared with subjects with higher vitamin D levels.In the GDM group,serum 25OHD was independently associated with HbA1c and insulin resistance after adjusting for confounding factors.In the NGT group,serum 25OHD was independently associated with fasting plasma glucose and systolic blood pressure after adjusting for maternal age and other confounding factors.Conclusion 25OHD insufficiency is very common in Chinese women.Low 25OHD status may be associated with insulin resistance and act as a risk factor for GDM. | WANG Ou NIE Min HU Ying Ying ZHANG Kui LI Wei PING Fan LIU Jun Tao CHEN Li Meng XING Xiao Ping | 2012 | Biomedical and Environmental Sciences2012，25，4： | 21 |
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