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| 1 | Three advantages of using traditional Chinese medicine to prevent and treat tumor显示文摘Traditional Chinese medicine(TCM), an important component of complementary and alternative medicine, has evolved over thousands of years with its own unique system of theories, diagnostics and therapies. TCM has been increasingly used in the last decades and become well known for its significant role in preventing and treating cancer. We believe that TCM possesses advantages over Western medicine in specific aspects at a certain stage of cancer treatment. Here we summarize the advantages of TCM from three aspects: preventing tumorigenesis; attenuating toxicity and enhancing the treatment effect; and reducing tumor recurrence and metastasis. | Chang-quan Ling Xiao-qiang Yue Chen Ling | 2014 | Journal of Integrative Medicine2014，12，4： | 83 |
| 2 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 3 | Identification and genetic mapping of four novel genes that regulate leaf development in Arabidopsis显示文摘Molecular and genetic characterizations of mutants have led to a better understanding of many developmental processes in the model system Arabidopsis thaliana. However, the leaf development that is specific to plants has been little studied. With the aim of contributing to the genetic dissection of leaf development, we have performed a large-scare screening for mutants with abnormal leaves. Among a great number of leaf mutants we have generated by T-DNA and transposon tagging and ethylmethae sulfonate (EMS) mutagenesis, four independent mutant lines have been identified and studied genetically. Phenotypes of these mutant lines represent the defects of four novel nuclear genes designated LL1 (LOTUS LEAF 1), LL2 (LOTUS LEAF 2), URO (UPRIGHT ROSETTE), and EIL (ENVIRONT CONDITION INDUCED LESION). The phenotypic analysis indicates that these genes play important roles during leaf development. FOr the further genetic analysis of these genes and the map-based cloning of LL1 and LL2, we have mapped these genes to chromosome regions with an efficient and rapid mapping method. | SUN YUE WEI ZHANG FENG LING LI YING LI GUO TIAN LEI LIU HAI HUANG | 2000 | Cell Research2000，10，4： | 53 |
| 4 | Mortality and Morbidity of Extremely Low Birth Weight Infants in the Mainland of China: A Multi-center Study显示文摘 | Hui-Jia Lin Li-Zhong Du Xiao-Lu Ma Li-Ping Shi Jia-Hua Pan Xiao-Mei Tong Qiu-Ping Li Jian-Guo Zhou Bing Yi Ling Liu Yun-Bing Chen Qiu-Fen Wei Hui-Qing Wu Mei Li Cui-Qing Li Xi-Rong Gao Shi-Wen Xia Wen-Bin Li Chao-Ying Ya Ling He Kun Liang Xiao-Yu Zhou Shu-Ping Han Qin Lyu Yin-Ping Qiu Wen Li Dong-Mei Chen Hong-Ru Lu Xiao-Hong Liu Hong Liu Zhen-Lang Lin Li Liu Jia-Jun Zhu Hong Xiong Shao-Jie Yue Si-Qi Zhuang | 2015 | Chinese Medical Journal2015，，20： | 49 |
| 5 | The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer显示文摘Background:N6-methyladenosine(m6A)RNA modification has been demonstrated to be a significant regulatory process in the progression of various tumors,including breast cancer.Fat mass and obesity-associated(FTO)enzyme,initially known as the obesity-related protein,is the first identified m6A demethylase.However,the relationship between FTO and breast cancer remains controversial.In this study,we aimed to elucidate the role and clinical significance of FTO in breast cancer and to explore the underlying mechanism.Methods:We first investigated the expression of FTO in breast cancer cell lines and tissues by quantitative reverse transcription-PCR(qRT-PCR),Western blotting,and immunohistochemistry.Wound healing assay and Transwell assay were performed to determine the migration and invasion abilities of SKBR3 and MDAMB453 cells with either knockdown or overexpression of FTO.RNA sequencing(RNA-seq)was conducted to decipher the downstream targets of FTO.qRT-PCR,luciferase reporter assay,and Western blotting were employed to confirm the existence of the FTO/miR-181b-3p/ARL5B axis.The biological function of ADP ribosylation factor like GTPase 5B(ARL5B)in breast cancer cells was evaluated by wound healing assay and Transwell invasion assay.Results:High FTO expression was observed in human epidermal growth factor receptor 2(HER2)-positive breast cancer,predicting advanced progression(tumor size[P<0.001],nuclear grade[P=0.001],peritumoral lymphovascular invasion[P<0.001),lymph node metastasis[P=0.002],and TNM stage[P=0.001])and poor prognosis.Moreover,FTO promoted cell invasion and migration in vitro.Mechanistically,RNA-seq and further confirmation studies suggested that FTO up-regulated ARL5B by inhibiting miR-181b-3p.We further verified that ARL5B also displayed carcinogenic activity in breast cancer cells.Conclusion:Our work demonstrated the carcinogenic activity of FTO in promoting the invasion and migration of breast cancer cells via the FTO/miR-181b-3p/ARL5B signaling pathway. | Yuanyuan Xu Shuang Ye Nan Zhang Shuhui Zheng Huatao Liu Kewen Zhou Ling Wang Yue Cao Peng Sun Tinghuai Wang | 2020 | Cancer Communications2020，40，10： | 24 |
| 6 | Quercetin protects rat dorsal root ganglion neurons against high glucose-induced injury in vitro through Nrf-2/HO-1 activation and NF-κB inhibition显示文摘 | Yue Shi Xiao-chun Liang Hong Zhang Qun-li Wu Ling Qu Qing Sun | 2013 | Acta Pharmacologica Sinica2013，34，9： | 16 |
| 7 | Effects of long-term,low-dose sex hormone replacement therapy on hippocampus and cognition of postmenopausal women of different apoE genotypes显示文摘瞄准:学习效果长期,体积和在带 apolipoprotein E ( apoE )的绝经后的女人的马头鱼尾的怪兽的生物化学的变化上的低剂量的性荷尔蒙代替治疗( HRT )基因 epsilon 3 或 epsilon 4 .Methods :使用 HRT 的低剂量超过 4 年了的 83 个绝经后的女人作为 HRT 组被选择,并且当控制 group.ApoE 等位基因被 PCR.Magnetic 回声成像分析,有匹配的年龄和教育的 99postmenopausal 女人被注册被执行决定 brainhippocampus.Proton 的卷磁性的回声光谱学被用来在 apoE epsilon 在前面的 cingulate 外皮和马头鱼尾的怪兽检测生物化学的变化 4 并且 epsilon 3 个搬运人。六普通认知测试被用来做认知 function.Results 的全面评估: 有 4 个搬运人显示出的 apoE epsilon 的分析控制组的马头鱼尾的怪兽的卷是比 HRT 组的那些显著地低的。生物化学的分析证明有 N-acetylaspartate (NAA )/total 肌酸(tCr ) 和 myoinositol (mI ) 的减少的增加在在 HRT 的 4 个搬运人组织的 apoE epsilon 的马头鱼尾的怪兽的 /tCr,与控制组相比。为 apoEepsilon 3 个搬运人, HRT 组的最少的广场工具(LSMEAN ) 比控制 group.Conclusion 的高: 这研究证明长期的、低剂量 HRT 可能为在脆弱的绝经后的女人减少广告开发的风险是有益的。同时, HRT 能增加 apoE epsilon 的 LSMEAN 3 个搬运人。 | Yun YUE Ling HU Qin-jie TIAN Jing-mei JIANG Yi-long DONG Zheng-yu JIN yu-hang CHENG Xia HONG Qin-sheng GE Ping-ping ZUO | 2007 | Acta Pharmacologica Sinica2007，28，8： | 15 |
| 8 | Clinical evaluation of valsartan and metoprolol tartrate in treatment of diabetic nephropathy with positive β1-adrenergic and anti-angiotensin Ⅱ type 1 receptor antibody显示文摘 | ZHAO Lin-shuang BAI Wei-wei XIANG Guang-da YUE Ling SUN Hui-ling | 2012 | Chinese Medical Journal2012，，19： | 15 |
| 9 | Breviscapine reduces neuronal injury caused by traumatic brain injury insult:partly associated with suppression of interleukin-6 expression显示文摘Breviscapine,extracted from the herb Erigeron breviscapus,is widely used for the treatment of cardiovascular diseases,cerebral infarct,and stroke,but its mechanism of action remains unclear.This study established a rat model of traumatic brain injury induced by controlled cortical impact,and injected 75 μg breviscapine via the right lateral ventricle.We found that breviscapine significantly improved neurobehavioral dysfunction at 6 and 9 days after injection.Meanwhile,interleukin-6 expression was markedly down-regulated following breviscapine treatment.Our results suggest that breviscapine is effective in promoting neurological behavior after traumatic brain injury and the underlying molecular mechanism may be associated with the suppression of interleukin-6. | Ling Jiang Yue Hu Xiang He Qiang Lv Ting-hua Wang Qing-jie Xia | 2017 | Neural Regeneration Research2017，12，1： | 14 |
| 10 | Diagnosis and endovascular treatment of spontaneous direct carotid-cavernous fistula显示文摘背景自发的直接颈动脉多孔的管( CCF )是相对稀罕的,很少报告在纸是报导临床的特征的这的 literature.The 目的被发现了,成像调查结果和为有自发的直接 CCF 的九个病人的临床的数据在2003年5月和2007年11月和 endovascular treatment.Sudden neuro-ophthalmologic 的结果之间招收的有我们回顾地分析了的自发的直接 CCF.Methods 的病人的 endovascular | YU Jia-sheng LEI Ting CHEN Jin-cao HE Yue CHEN Jian LI Ling | 2008 | Chinese Medical Journal2008，，16： | 12 |
| 11 | Exosome-functionalized magnesium-organic framework-based scaffoldswith osteogenic, angiogenic and anti-inflammatory properties foraccelerated bone regeneration显示文摘Exosomes derived from human adipose-derived stem cells (hADSCs-Exos) have shown potential as an effectivetherapeutic tool for repairing bone defects. Although metal-organic framework (MOF) scaffolds are promisingstrategies for bone tissue regeneration, their potential use for exosome loading remains unexplored. In this study,motivated by the potential advantages of hADSCs-Exos and Mg-GA MOF, we designed and synthesized anexosome-functionalized cell-free PLGA/Mg-GA MOF (PLGA/Exo-Mg-GA MOF) scaffold, taking using of thebenefits of hADSCs-Exos, Mg2+, and gallic acid (GA) to construct unique nanostructural interfaces to enhanceosteogenic, angiogenic and anti-inflammatory capabilities simultaneously. Our in vitro work demonstrated thebeneficial effects of PLGA/Exo-Mg-GA MOF composite scaffolds on the osteogenic effects in human bonemarrow-derived mesenchymal stem cells (hBMSCs) and angiogenic effects in human umbilical endothelial cells(HUVECs). Slowly released hADSCs-Exos from composite scaffolds were phagocytosed by co-cultured cells,stabilized the bone graft environment, ensured blood supply, promoted osteogenic differentiation, and acceleratedbone reconstruction. Furthermore, our in vivo experiments with rat calvarial defect model showed thatPLGA/Exo-Mg-GA MOF scaffolds promoted new bone formation and satisfactory osseointegration. Overall, weprovide valuable new insights for designing exosome-coated nanocomposite scaffolds with enhanced osteogenesisproperty. | Yue Kang Chang Xu Ling’ao Meng Xufeng Dong Min Qi Daqing Jiang | 2022 | Bioactive Materials2022，7，12： | 11 |
| 12 | Combination of Quercetin, Cinnamaldehyde and Hirudin Protects Rat Dorsal Root Ganglion Neurons against High Glucose-Induced Injury through Nrf-2/HO-1 Activation and NF-κB Inhibition显示文摘Objective: To examine the effects of the combination of quercetin(Q), cinnamaldehyde(C) and hirudin(H), a Chinese medicine formula on high glucose(HG)-induced apoptosis of cultured dorsal root ganglion(DRG) neurons. Methods: DRG neurons exposed to HG(45 mmol/L) for 24 h were employed as an in vitro model of diabetic neuropathy. Cell viability, reactive oxygen species(ROS) level and apoptosis were determined. The expression of nuclear factor of Kappa B(NF-κB), inhibitory kappa Bα(IκBα), phosphorylated IκBα and Nf-E2 related factor 2(Nrf2) were examined using reverse transcription-polymerase chain reaction(RT-PCR) and Western blot assay. The expression of hemeoxygenase-1(HO-1), interleukin-6(IL-6), tumor necrosis factor(TNF-α) and caspase-3 were also examined by RT-PCR and Western blot assay. Results: HG treatment markedly increased DRG neuron apoptosis via increasing intracellular ROS level and activating the NF-κB signaling pathway(P<0.05). Co-treatment with Q, C, H and their combination decreased HG-induced caspase-3 activation and apoptosis(P<0.05 or P<0.01). The expressions of NF-κB, IL-6 and TNF-α were downregulated, and Nrf2/HO-1 expression was up-regulated(P<0.05 or P<0.01). QCH has better effect in scavenging ROS, activating Nrf-2/HO-1, and down-regulating the NF-κB pathway than other treatment group. Conclusions: DRG neurons' apoptosis was increased in diabetic conditions, which was reduced by QCH formula treatment. The possible reason could be activating Nrf-2/HO-1 pathway, scavenging ROS, and inhibition of NF-κB activation. The effect of QCH combination was better than each monomer or the combination of the two monomers. | SHI Yue LIANG Xiao-chun ZHANG Hong SUN Qing WU Qun-li QU Ling | 2017 | Chinese Journal of Integrative Medicine2017，23，9： | 11 |
| 13 | Development of a supercritical and an ultra-supercritical circulating fluidized bed boiler显示文摘The supercritical circulating fluidized bed(CFB)boiler,which combines the advantages of CFB combustion with low cost emission control and supercritical steam cycle with high efficiency of coal energy,is believed to be the future of CFB combustion technology.It is also of greatest importance for low rank coal utilization in China.Different from the supercritical pulverized coal boiler that has been developed more than 50 years,the supercritical CFB boiler is still a new one which requires further investigation.Without any precedentor engineering reference,Chinese researchers have con ducted fundamental research,development,design of the supercritical CFB boilers independently.The design theory and key technology for supercritical CFB boiler were proposed.Key components and novel structures were invented.The first 600 MWe supercritical CFB boiler and its auxiliaries were successfully developed and demonstrated in Baima Power Plant,Shenhua Group as well as the simulator,control technology,installation technology,commissioning technology,system integration and operation technology.Compared with the 460 MWe supercritical CFB in Poland,developed in the same period and the only other supercritical one of commercial running in the word beside Baima,the 600 MWe one in Baima has a better performance.Besides,supercritical CFB boilers of 350 MWe have been developed and widely commercialized in China.In this paper,the updated progress of 660 MWe ultra-supercritical CFB boilers under development is introduced. | Junfu LYU Hairui YANG Wen LING Li NIE Guangxi YUE Ruixin LI Ying CHEN Shilong WANG | 2019 | Frontiers in Energy2019，13，1： | 11 |
| 14 | Continuous Positive Airway Pressure Effectively Alleviates Arrhythmias in Patients with Obstructive Sleep Apnea:Possible Relationship with Counteracting Oxidative Stress显示文摘This work is aimed at exploring the clinical efficacy of continuous positive airway pressuie(CPAP)in treatment of patients with arrhythmias combined with obstructive sleep apnea(OSA).Through evaluating serum native thiol,malonaldehyde(MDA)and nicotinamide adenine dinucleotide phosphate oxidase(NADPH oxidase)in these patients and describing the effects on oxidative parameters of CPAP therapy for 3 months,we confirmed the impact of oxidative stress on arrhythmias.A total of 64 patients with OSA combined with arrhythmias were collected from April 2014 to April 2017 with full clinical information.Patients were divided into two groups(paired experiment design):32 patients in group A(control group),who received unchanged anti-arrhythmia treatment and 32 patients in group B,who were subjected to unchanged pharmacological anti-arrhythmia therapy combined with CPAP.OSA related parameters were compared between the two groups after 3-month therapy.And the levels of parameters of oxidative stress in patients were measured before and after CPAP therapy.After 3 months of CPAP therapy,compared with the control group,the percentage of sage N3(NREM 3)and stage R(REM)in total sleep time was significantly increased,while apnea-hypopnea index(AHI)and the Epworth Sleepiness Scale(ESS)score were evidently decreased.Meanwhile,the lowest oxygen saturation(LSpCh)was also elevated after CPAP treatment for 3 months.The CPAP therapy significantly prevented the occurrence of arrhythmias(P<0.05).Both the MDA level and NADPH oxidase levels were significantly lower in the group B than in the group A(P<0.05).But serum native thiol was improved by CPAP treatment(P<0.05).In conclusion,proper use of CPAP therapy provides significant benefits for the treatment of arrhythmia in patients with OSA. | Xiao-ting WANG Gang ZHAO Ling TU Zhi-yong YUE Zhen-hua LIU Jie HAN Kun GAO Xuan-chen ZHOU Shuai XU Jian-feng LI | 2019 | Current Medical Science2019，39，1： | 10 |
| 15 | Total polysaccharides of the Sijunzi decoction attenuate tumor necrosis factor-α-induced damage to the barrier function of a Caco-2 cell monolayer via the nuclear factor-κB-myosin light chain kinase-myosin light chain pathway显示文摘AIM To explore the protective effects and underlying mechanisms of total polysaccharides of the Sijunzi decoction(TPSJ) on the epithelial barriers in vitro. METHODS Caco-2 cell monolayers were treated with or without TPSJ in the presence or absence of TNF-α, and paracellular permeability and transepithelial electrical resistance(TEER) were measured to evaluate the epithelial barrier function. Immunofluorescence and western blotting were respecti-vely used to evaluate the distribution and expression of the tight junction proteins claudin 1, claudin 2, zo3, and occludin in Caco-2 cells. western blotting was also used to evaluate the cellular expression of myosin light chain(MLC), phosphorylated MLC(pM LC), MLC kinase(MLCK), and nuclear factor(NF)-κB p65. RESULTS TPSJ promoted the proliferation of Caco-2 cells and inhibited TNF-α-induced secretion of pro-inflammatory cyto-kines. Furthermore, TPSJ significantly ameliorated both the reduction of TEER and the increased paracellular permeability observed in tumor necrosis factor(TNF)-α-damaged Caco-2 monolayers. Furthermore, TPSJ remarkably attenuated TNF-α-induced morphological changes, downregulated the expression of claudin 1, claudin 2, zo3, and occludin, and markedly suppressed TNF-α-mediated upregulation of p-MLC and MLCK expression. Finally, TPSJ inhibited the activation and expression of NF-κB p65. CONCLUSION Our results demonstrate that TPSJ alleviates the TNF-α-induced impairment of the intestinal epithelial cell barrier function by suppressing NF-κB p65-mediated phosphorylation of MLCK and MLC. | Yue Lu Leng Li Jin-wei Zhang Xiao-qin Zhong Jian-An wei Ling Han | 2018 | World Journal of Gastroenterology2018，24，26： | 10 |
| 16 | A hybrid model for dissolved oxygen prediction in aquaculture based on multi-scale features显示文摘To increase prediction accuracy of dissolved oxygen(DO)in aquaculture,a hybrid model based on multi-scale features using ensemble empirical mode decomposition(EEMD)is proposed.Firstly,original DO datasets are decomposed by EEMD and we get several components.Secondly,these components are used to reconstruct four terms including high frequency term,intermediate frequency term,low frequency term and trend term.Thirdly,according to the characteristics of high and intermediate frequency terms,which fluctuate violently,the least squares support vector machine(LSSVR)is used to predict the two terms.The fluctuation of low frequency term is gentle and periodic,so it can be modeled by BP neural network with an optimal mind evolutionary computation(MEC-BP).Then,the trend term is predicted using grey model(GM)because it is nearly linear.Finally,the prediction values of DO datasets are calculated by the sum of the forecasting values of all terms.The experimental results demonstrate that our hybrid model outperforms EEMD-ELM(extreme learning machine based on EEMD),EEMD-BP and MEC-BP models based on the mean absolute error(MAE),mean absolute percentage error(MAPE),mean square error(MSE)and root mean square error(RMSE).Our hybrid model is proven to be an effective approach to predict aquaculture DO. | Chen Li Zhenbo Li Jing Wu Ling Zhu Jun Yue | 2018 | Information Processing in Agriculture2018，5，1： | 10 |
| 17 | 坦索罗辛改变左氧氟沙星在患急性细菌性前列腺炎的大鼠前列腺中的药代动力学显示文摘左氧氟沙星和a1-肾上腺素受体阻滞剂联合用药是目前治疗细菌性和非细菌性前列腺炎的常用方法。该研究的主要目的是探讨联合用药时,a1-肾上腺素受体阻滞剂对急性细菌性前列腺炎模型大鼠各组织中左氧氟沙星药代动力学的影响。将96只急性细菌性前列腺炎模型大鼠随机分为实验组(坦索罗辛和左氧氟沙星联合用药组)和对照组(单用左氧氟沙星组),每组48只,分别在给药后o.125、0.25、0.5、1、2、4、85n12h每个时间点处死6只大鼠,采集两组动物的血液、肝脏、肾脏和前列腺制作组织匀浆,用高效液相色谱(HPLC)法测定各组织中左氧氟沙星的药物浓度,3p97软件计算药物动力学参数。结果表明实验组和对照组中血浆、肝脏和肾脏组织中左氧氟沙星的主要药代动力学参数,包括半衰期(t1/2)、达峰时间(tpeak)、清除率(CL)、最大药物浓度(Cmax)和曲线下面积(AUC0-12),均无明显差异(P〉0.05);而在前列腺组织中,坦索罗辛明显提高了左氧氟沙星的最大药物浓度(Cmax)、延长了药物半衰期(t1/2),且降低了药物清除率(CL)(P〈0.05)。因此,该研究结果表明联合用药时坦索罗辛可能增强左氧氟沙星在治疗细菌性前列腺炎时的疗效,而对其在肝脏和肾脏组织中的药物浓度无明显影响。 | Guo-Dong Qin Ming-Zhao Xiao Yuan-Da Zhou ling Yang Hai-Xia He Yue He Yang Zeng | 2013 | Asian Journal of Andrology2013，15，2： | 9 |
| 18 | Dissecting and Enhancing the Contributions of High-Molecular-Weight Glutenin Subunits to Dough Functionality and Bread Quality显示文摘Dear Editor, Seed storage proteins (SSPs) are frequently important determinants of crop quality traits (Shewry and Casey,1999).Dissecting and enhancing the genetic contributions of individual SSPs to their target traits are essential for effectively improving crop quality attributes.However,such a task is often difficult to accomplish,because SSPs are frequently expressed from multigene families and exhibit strong allelic variation.Consequently,detailed knowledge of the function of individual SSPs in crop quality trait is still limited.This scenario is well illustrated by high-molecular-weight glutenin subunits (HMWGSs),a complex family of SSPs that are involved in wheat enduse quality through affecting dough functionality (Békés,2012;Rasheed et al.,2014). | Yiwen Li Xuefi An Ran Yang Xiaomin Guo Guidong Yue Renchun Fan Bin Li Zhensheng Li Kunpu Zhang Zhenying Dong Luyan Zhang Jiankang Wang Xu Jia Hong-Qing Ling Aimin Zhang Xiangqi Zhang Daowen Wang | 2015 | Molecular Plant2015，8，2： | 9 |
| 19 | The Effect of PCDH15 Gene Variations on the Risk of Noise-induced Hearing Loss in a Chinese Population显示文摘导致噪音的听觉损失(NIHL ) 是在环境、基因的因素之间的相互作用引起的复杂疾病。这研究调查了在 protocadherin 的基因可变性是否联系了 15 (PCDH15 ) 在一张中国人口位于增加的危险性下面到 NIHL 的发展。结果证明与 rs11004085 的 TT 遗传型相比, CT/CC 遗传型与 NIHL 的增加的风险被联系[调整机会比率(或)= 2.64;95% 信心间隔(CI ) :1.14-6.11, P = 0.024 ] 。另外,在 rs11004085 和 rs978842 之间的重要相互作用基因变化和噪音暴露在高级暴露组被观察(P < 0.05 ) 。而且,当与噪音暴露的高水平结合了时,风险 haplotype TAGCC 被观察(P < 0.05 ) 。因此,我们的学习证实在 PCDH15 的基因变化在人修改危险性到 NIHL 开发。 | XU Xiang Rong WANG Jing Jing YANG Qiu Yue JIAO Jie HE Li Hua YU Shan Fa GU Gui Zhen CHEN Guo Shun ZHOU Wen Hui WU Hui LI Yan Hong ZHANG Huan Ling ZHANG Zeng Rui JIN Xian Ning | 2017 | Biomedical and Environmental Sciences2017，30，2： | 9 |
| 20 | IL-37b suppresses T cell priming by modulating dendritic cell maturation and cytokine production via dampening ERK/NF-κB/S6K signalings显示文摘Interleukin 37b (IL-37b ) 在压制有免疫力的回答起一个关键作用,部分由 modulating 树枝状的房间(DC ) 的功能。然而,精确机制大部分仍然是未知的。这里,我们在回答由 DC 导致了的 DC 成熟和 T 房间上调查了 IL-37b 的效果,并且探索了深奥发信号的小径。它被发现那 IL-37b 下面调整在 vitro 的 DC 上的 co-stimulatory 分子 CD80 和 CD86 的表情。同时,支持 inflammatory cytokines 的表情例如 TNF-6, 和 IL-6,被压制,当时 T 房间的表示禁止的 cytokine TGF- 在 IL-37b-treated DC 被增加。另外, T 房间上的 DC 的激活效果被 IL-37b 损害。我们进一步表明细胞外的调整单人赛的 kinase (英皇家空军之阶级最低之兵) ,原子 factor-B (NF-B ) ,和表明小径的 mTOR-S6K 涉及 IL-37b 导致的 DC 的抑制。这被化学禁止者的同样镇压的效果在 DC 在 IL-6 和 TNF- 的表情上对 NF-B,英皇家空军之阶级最低之兵,和 S6K 证实。在结论,这些结果证明 IL-37b 由在英皇家空军之阶级最低之兵, NF-B,和基于 S6K 的禁止的发信号小径包含在 T 房间 priming 压制了 DC 成熟和 immunostimulatory 能力。 | Wantong Wu Weiqiang Wang Yun Wang Wenwen Li Gang Yu Zhonglong Li Chunmin Fang Yue Shen Zhina Sun Ling Han Juan Yu Lijun Fang Song Chen Kui Dong Zhongchao Han Hanzhi Liu Yuechen Luo Xiaoming Feng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
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