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| 1 | Experimental Study of Effects of Tip Geometry on the Flow Field in a Turbine Cascade Passage显示文摘This study investigates the effects of blade tip geometry on the flow field of a turbine cascade at the incidence angle of 0 degree experimentally. The tests were performed in a low-speed turbine cascade wind tunnel. The Reynolds number based on the blade chord was about 172300 at the exit. Traverses of the exit flow field were made in order to measure the overall performance. The effects of using flat tip and grooved tip with a chord-wise channel were studied. The case with the flat tip is referenced as the baseline. The tip clearances are all 1 mm measuring 0.84 percent of the blade span. The depth of channel is 2mm.The flow field at 10% chord downstream from the cascade trailing edge was measured at 38 span-wise positions and 26 pitch-wise positions using a mini five-hole pressure probe. The static pressure distribution on the tip end wall is measured at 16 pitch-wise stations and 17 chord-wise stations. Results show that there exists great pressure gradient in the pressure side for the flat tip and the pressure side squealer tip, which means strong leakage flow. The pressure gradient from the pressure side to the suction side is greatly decreased for the grooved tip, and the resulting leakage flow is weaker. The core of the leakage vortex moves closer to the suction side for the pressure side squealer tip and farther away from the suction side for the suction side squealer tip. The pressure side squealer has little advantages over the flat tip in improving the flow capacity and reducing the overall losses. The suction side squealer tip and grooved tip can effectively decrease the intensity of the tip leakage vortex, improve the flow capacity and reduce loss of the turbine cascade passage and the grooved tip performs the best. | MA Hongwei WANG Lixiang | 2015 | Journal of Thermal Science2015，24，1： | 6 |
| 2 | Adipocyte-derived SFRP5 inhibits breast cancer cells migration and invasion through Wnt and epithelial-mesenchymal transition signaling pathways显示文摘Objective:Obesity is closely associated with metastasis in breast cancer patients.Secreted frizzled-related protein 5(SFRP5),one of the novel adipokines with anti-inflammatory properties,is associated with obesity.This study aims to study the role of SFRP5 in the crosstalk between obesity and breast cancer metastasis and identify the underlying mechanism.Methods:3T3-L1 pre-adipocytes were differentiated to mature adipocytes and a hypertrophic adipocyte model was induced with palmitic acid(PA).Cell motility was measured in MDA-MB-231 and MCF-7 breast cancer cells co-cultured with adipocytes conditioned medium(CM)with or without SFRP5 protein.Wnt and epithelialmesenchymal transition(EMT)signal pathways were investigated by western blot.Circulating SFRP5 level in 218 breast cancer patients and the association with clinicopathologic characteristics of breast cancer were further determined.Online databases ENCORI and PREDICT Plus were used to exam the link between SFRP5 and prognosis.Results:Reduced SFRP5 level was detected in the hypertrophic adipocyte model.Recombinant SFRP5 protein inhibited MDA-MB-231 and MCF-7 cells invasion and migration induced by PA-treated adipocyte CM,and SFRP5 inhibition by specific antibody reversed the effect of SFRP5.Furthermore,SFRP5 significantly inhibited Wnt and downstream EMT in breast cancer cells.Low circulating SFRP5 level correlated with body mass index(BMI),lymph node(LN)metastasis,TNM stage and high Ki67 expression in breast cancer patients.Increased SFRP5 level was associated with favorable predicted survival.Kaplan-Meier curves showed high SFRP5 level in tumor tissue was associated with better outcome of breast cancer patients.Conclusions:Our findings demonstrated SFRP5 is a vital adipokine that mediates the crosslink between obesity and the metastatic potential of breast cancer.Promotion of SFRP5 expression in the adipose microenvironment may represent a novel approach for preventing breast cancer metastasis. | Wenzhong Zhou Chunmiao Ye Liang Li Liyuan Liu Fei Wang Lixiang Yu Fei Zhou Yujuan Xiang Yongjiu Wang Gengshen Yin Zhongbing Ma Qinye Fu Qiang Zhang Dezong Gao Shuya Huang Zhigang Yu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 5 |
| 3 | Base editing-mediated splicing correction therapy for spinal muscular atrophy显示文摘Dear Editor,Spinal muscular atrophy(SMA)is a devastating autosomal recessive motor neuron disease.1,2 Infants with more severe forms of type I SMA die before the age of 2 if no intervention is provided.1,2 Spinraza and zolgensma have been approved by the FDA as SMA therapeutics for pediatric patients.1,2 However,as an antisense oligonucleotide(ASO)based therapy,spinraza requires four loading doses,followed by three annual maintenance doses.The patients would be subjected to repeated intrathecal injections in the procedure.Zolgensma is a single-dose gene-replacement therapy for SMA,but unfortunately is unreliable in maintaining a high,stable level of gene expression.These issues have limited the therapeutic effects of the two approved drugs for SMA. | Xiang Lin Haizhu Chen Ying-Qian Lu Shunyan Hong Xinde Hu Yanxia Gao Lu-Lu Lai Jin-Jing Li Zishuai Wang Wenqin Ying Lixiang Ma Ning Wang Erwei Zuo Hui Yang Wan-Jin Chen | 2020 | Cell Research2020，30，6： | 5 |
| 4 | Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models显示文摘 | Meng Yu Yuhua Fu Yijian Liang Haikun Song Yao Yao Peng Wu Yuwei Yao Yuyin Pan Xue Wen Lixiang Ma Saiyin Hexige Yu Ding Shouqing Luo Boxun Lu | 2017 | Cell Research2017，27，12： | 5 |
| 5 | Tau Accumulation via Reduced Autophagy Mediates GGGGCC Repeat Expansion-Induced Neurodegeneration in Drosophila Model of ALS显示文摘Expansions of trinucleotide or hexanucleotide repeats lead to several neurodegenerative disorders,including Huntington disease[caused by expanded CAG repeats(CAGr)in the HTT gene],and amyotrophic lateral sclerosis[ALS,possibly caused by expanded GGGGCC repeats(G4C2r)in the C9ORF72 gene],of which the molecular mechanisms remain unclear.Here,we demonstrated that lowering the Drosophila homologue of tau protein(dtau)significantly rescued in vivo neurodegeneration,motor performance impairments,and the shortened life-span in Drosophila expressing expanded CAGr or expanded G4C2r.Expression of human tau(htau4 R)restored the disease-related phenotypes that had been mitigated by the loss of dtau,suggesting an evolutionarily-conserved role of tau in neurodegeneration.We further revealed that G4C2r expression increased tau accumulation by inhibiting autophagosome-lysosome fusion,possibly due to lowering the level of BAG3,a regulator of autophagy and tau.Taken together,our results reveal a novel mechanism by which expanded G4C2r causes neurodegeneration via an evolutionarily-conserved mechanism.Our findings provide novel autophagy-related mechanistic insights into C9ORF72-ALS and possible entry points to disease treatment. | Xue Wen Ping An Hexuan Li Zijian Zhou Yimin Sun Jian Wang Lixiang Ma Boxun Lu | 2020 | Neuroscience Bulletin2020，36，12： | 4 |
| 6 | Establishment of novel rat models for premalignant breast disease显示文摘 | Wang Feng Ma Zhongbing Wang Fei Fu Qinye Fang Yunzhi Zhang Qiang Gao Dezong Li Yuyang Li Liang Yu Lixiang Yu Zhigang | 2014 | Chinese Medical Journal2014，，11： | 4 |
| 7 | Experimental Investigation of Effects of Suction-Side Squealer Tip Geometry on the Flow Field in a Large-scale Axial Compressor using SPIV显示文摘It is well known that the non-uniform tip geometry is a promising passive flow control technique in turbomachinery.However,detailed investigation of its effects on the unsteady flow field of turbomachinery is rare in the existiug hteratures.This paper presents an experimental investigation of effects of suction side squealer tip configuration on both the steady and unsteady flow field of an isolated compressor rotor.The flow field at 10%chord downstream from the trailing edge was measured using a mini five-hole probe.Meanwhile,the unsteady flow field inside the passage was investigated using stereo particle image velocimetry(SPIV).The steady results show that the SSQ tip configuration exerts positive effect on the static pressure rise performance of this compressor,and the radial equilibrium at the rotor outlet is obviously rearranged.The SSQ tip configuration would create a stronger tip leakage vortex at the formation phase,and it experiences a faster dissipation process around the rear chord.Also,the splitting process of the tip leakage vortex is severer,which is the main cause of the relatively higher probability of the presence of the streamwise reverse flow.The quantitatively analysis of the tip leakage vortex indicates that the velocity loss inside the blockage region is direct response of the evolutionary procedure of the tip leakage vortex.It keeps increasing until the end of the splitting process.Although the blockage coefficient grows sustainably,the velocity loss will reduce once the turbulent mixing procedure is dominant. | MA Hongwei WEI Wei WANG Lixiang TIAN Yangtao | 2015 | Journal of Thermal Science2015，24，4： | 4 |
| 8 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 9 | Gedunin Degrades Aggregates of Mutant Huntingtin Protein and Intranuclear Inclusions via the Proteasomal Pathway in Neurons and Fibroblasts from Patients with Huntington’s Disease显示文摘Huntington's disease(HD) is a deadly neurodegenerative disease with abnormal expansion of CAG repeats in the huntingtin gene. Mutant Huntingtin protein(m HTT) forms abnormal aggregates and intranuclear inclusions in specific neurons, resulting in cell death. Here,we tested the ability of a natural heat-shock protein 90 inhibitor, Gedunin, to degrade transfected m HTT in Neuro-2 a cells and endogenous m HTT aggregates and intranuclear inclusions in both fibroblasts from HD patients and neurons derived from induced pluripotent stem cells from patients. Our data showed that Gedunin treatment degraded transfected m HTT in Neuro-2 a cells, endogenous m HTT aggregates and intranuclear inclusions in fibroblasts from HD patients, and in neurons derived from induced pluripotent stem cells from patients in a dose-and time-dependent manner, and its activity depended on the proteasomal pathway rather than the autophagy route. These findings also showed that although Gedunin degraded abnormal m HTT aggregates and intranuclear inclusions in cells from HD patient, it did not affect normal cells, thus providing a new perspective for using Gedunin to treat HD. | Weiqi Yang Jingmo Xie Qiang Qiang Li Li Xiang Lin Yiqing Ren Wenlei Ren Qiong Liu Guomin Zhou Wenshi Wei Hexige Saiyin Lixiang Ma | 2019 | Neuroscience Bulletin2019，35，6： | 2 |
| 10 | The S 1P, receptor-selective agonist CYM-5442 reduces the severity of acute GVHD byinhibiting macrophage recruitment显示文摘FTY720,为五已知的 sphingosine-1-phosphate (S1P ) 中的四个的收缩筋受体,被报导了禁止尖锐 graft-versus-host 疾病(aGVHD ) 。因为 FTY720 通过多重 S1P 受体工作,通过至少一这些受体的行动的机制可以说明它的副作用。因此,更选择的 S1P 受体调节的人被需要评估不同 S1P 受体和他们的治疗学的功效的角色。在这研究,我们调查了 S1P 1-selective 收缩筋的效果, CYM-5442,在 aGVHD 的前进上。我们显示出显著地禁止的那 CYM-5442 但是没阻止 aGVHD。CYM-5442 没影响施主 T 细胞的渗入进目标器官,当在 GVHD 器官的巨噬细胞的数字被 CYM-5442 处理显著地减少时。在 vivo 增长,试金证明巨噬细胞的增长没被 CYM-5442 压制。用人的 endothelial 房间的进一步的研究在 endothelial 房间表明了那 CYM-5442 处理 downregulated CCL2 和 CCL7 表情,因此减少单核白血球,从纸巾,巨噬细胞发源的迁居。我们的数据在 aGVHD 和它行动的可能的机制表明 S1P 1-selective 收缩筋的治疗学的功效。结果建议进一步的调查为 aGVHD 作为潜在的治疗学的政体关于 CYM-5442 被需要。 | Qiao Cheng Shoubao Ma Dandan Lin Yu Mei Huanle Gong Lei Lei Yuanyuan Chen Ye Zhao Bo Hut Yan Wu Xiao Yu Lixiang Zhao Haiyan Liu | 2015 | Cellular & Molecular Immunology2015，12，6： | 2 |
| 11 | The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease显示文摘Mammary and extramammary Paget’s Diseases(PD)are a malignant skin cancer characterized by the appearance of Paget cells.Although easily diagnosed,its pathogenesis remains unknown.Here,single-cell RNA-sequencing identified distinct cellular states,novel biomarkers,and signaling pathways—including mTOR,associated with extramammary PD.Interestingly,we identified MSI1 ectopic overexpression in basal epithelial cells of human PD skin,and show that Msi1 overexpression in the epidermal basal layer of mice phenocopies human PD at histopathological,single-cell and molecular levels.Using this mouse model,we identified novel biomarkers of Paget-like cells that translated to human Paget cells.Furthermore,single-cell trajectory,RNA velocity and lineage-tracing analyses revealed a putative keratinocyte-to-Paget-like cell conversion,supporting the in situ transformation theory of disease pathogenesis.Mechanistically,the Msi1-mTOR pathway drives keratinocyte-Paget-like cell conversion,and suppression of mTOR signaling with Rapamycin significantly rescued the Paget-like phenotype in Msi1-overexpressing transgenic mice.Topical Rapamycin treatment improved extramammary PD-associated symptoms in humans,suggesting mTOR inhibition as a novel therapeutic treatment in PD. | Yongli Song Christian F.Guerrero-Juarez Zhongjian Chen Yichen Tang Xianghui Ma Cong Lv Xueyun Bi Min Deng Lina Bu Yuhua Tian Ruiqi Liu Ran Zhao Jiuzhi Xu Xiaole Sheng Sujuan Du Yeqiang Liu Yunlu Zhu Shi-jun Shan Hong-duo Chen Yiqiang Zhao Guangbiao Zhou Jianwei Shuai Fazheng Ren Lixiang Xue Zhaoxia Ying Xing Dai Christopher J.Lengner Bogi Andersen Maksim V.Plikus Qing Nie Zhengquan Yu-Show | 2020 | Cell Research2020，30，10： | 2 |
| 12 | Adsorption performance and mechanism of Schiff base functionalized polyamidoamine dendrimer/silica for aqueous Mn(Ⅱ) and Co(Ⅱ)显示文摘Schiff base functionalized polyamidoamine(PAMAM) dendrimer/silica were prepared for the adsorption of aqueous Mn(Ⅱ) and Co(Ⅱ).The effects that influence the adsorption were investigated systematically and the adsorption mechanism was illustrated by theoretical calculation.The optimum adsorption pH are 4 and 6 for Mn(II) and Co(Ⅱ).Adsorption kinetics follow pseudo-second-order model and the ratecontrolling step is film diffusion process.Adsorption isotherm shows that high initial metal ion concentration facilitates the uptake of metal ions.The adsorption capacity increases first and then decreases in the temperature range of 15-35℃.Density functional theory(DFT) calculation demonstrates that Schiff base functionalized PAMAM dendrimer tends to coordinate Mn(Ⅱ) and Co(Ⅱ) with the oxygen atoms of hydroxyl and carbonyl groups,nitrogen of tertiary amine and imino groups.The imino and tertiary amine groups mainly dominate the adsorption.The reproducibility of the adsorbents indicates they can be regenerated by 5% thiourea and 0.5 mol/L HNO_(3) solution efficiently. | Wenzhu Qiao Peixu Zhang Lixiang Sun Songmei Ma Wenlong Xu Shengguang Xu Yuzhong Niu | 2020 | Chinese Chemical Letters2020，31，10： | 2 |
| 13 | High efficiency fluorescent white organic light-emitting diodes with red, green and blue separately monochromatic emission layers显示文摘 | Zhiqiang Zhang Qi Wang Yanfeng Dai Yipeng Liu Lixiang Wang Dongge Ma | 2009 | Organic Electronics2009，，3： | 1 |
| 14 | A Comparative Study on Different Parallel Solvers for Nonlinear Analysis of Complex Structures显示文摘 | Lei Zhang Guoxin Zhang Lixiang Wang Zhaosong Ma Shihai Li Zhiqiang Hu | 2013 | Mathematical Problems in Engineering2013，，： | 1 |
| 15 | A GPU-Based Parallel Procedure for Nonlinear Analysis of Complex Structures Using a Coupled FEM/DEM Approach显示文摘 | Lixiang Wang Shihai Li Guoxin Zhang Zhaosong Ma Lei Zhang Zhiqiang Hu | 2013 | Mathematical Problems in Engineering2013，，： | 1 |
| 16 | A multi-objective chaotic particle swarm optimization for environmental/economic dispatch显示文摘 | Jiejin Cai Xiaoqian Ma Qiong Li Lixiang Li Haipeng Peng | 2009 | Energy Conversion and Management2009，，5： | 1 |
| 17 | 显示文摘 | Ma Dongge Liang Fushun Wang Lixiang | 2002 | Chemical Physics Letters2002，358，12： | 1 |
| 18 | Reduced efficiency roll-off in highly efficient and color-stable hybrid WOLEDs: The influence of triplet transfer and charge-transport behavior on enhancing device performance显示文摘 | Qi Wang Cheuk-Lam Ho Yongbiao Zhao Dongge Ma Wai-Yeung Wong Lixiang Wang | 2009 | Organic Electronics2009，，2： | 1 |
| 19 | Chaotic ant swarm optimization to economic dispatch 显示文摘 | CAI JIEJIN MA XIAOQIAN LI LIXIANG | 2007 | Electric Power Sys- tems Research2007，77，10： | 1 |
| 20 | TPC in the leaves of 116 sweet potato ( Ipomoea batatas L.) varieties and Pushu 53 leaf extracts显示文摘 | Wenqing Xu Lixiang Liu Bing Hu Yi Sun Hong Ye Daifu Ma Xiaoxiong Zeng | 2010 | Journal of Food Composition and Analysis2010，，6： | 1 |
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