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| 1 | Effects of baicalein on pancreatic cancer stem cells via modulation of sonic Hedgehog pathway显示文摘 | Libin Song Xiangyuan Chen Peng Wang Song Gao Chao Qu Luming Liu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，6： | 10 |
| 2 | Astronaut mass measurement using linear acceleration method and the effect of body non-rigidity显示文摘Astronaut's body mass is an essential factor of health monitoring in space.The latest mass measurement device for the International Space Station (ISS) has employed a linear acceleration method.The principle of this method is that the device generates a constant pulling force,and the astronaut is accelerated on a parallelogram motion guide which rotates at a large radius to achieve a nearly linear trajectory.The acceleration is calculated by regression analysis of the displacement versus time trajectory and the body mass is calculated by using the formula m=F/a.However,in actual flight,the device is instable that the deviation between runs could be 6-7 kg.This paper considers the body non-rigidity as the major cause of error and instability and analyzes the effects of body non-rigidity from different aspects.Body non-rigidity makes the acceleration of the center of mass (C.M.) oscillate and fall behind the point where force is applied.Actual acceleration curves showed that the overall effect of body non-rigidity is an oscillation at about 7 Hz and a deviation of about 25%.To enhance body rigidity,better body restraints were introduced and a prototype based on linear acceleration method was built.Measurement experiment was carried out on ground on an air table.Three human subjects weighing 60-70 kg were measured.The average variance was 0.04 kg and the average measurement error was 0.4%.This study will provide reference for future development of China's own mass measurement device. | YAN Hui LI LuMing HU ChunHua CHEN Hao HAO HongWei | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，4： | 6 |
| 3 | Carbothermic reduction of vanadium titanomagnetite with the assistance of sodium carbonate显示文摘The carbothermic reduction of vanadium titanomagnetite concentrate(VTC)with the assistance of Na_(2)CO_(3)was conducted in an argon atmosphere between 1073 and 1473 K.X-ray diffraction and scanning electron microscopy were used to investigate the phase transformations during the reaction.By investigating the reaction between VTC and Na_(2)CO_(3),it was concluded that molten Na_(2)CO_(3)broke the structure of titanomagnetite by combining with the acidic oxides(Fe_(2)O_(3),TiO_(2),Al_(2)O_(3),and SiO_(2))to form a Na-rich melt and release FeO and MgO.Therefore,Na_(2)CO_(3)accelerated the reduction rate.In addition,adding Na_(2)CO_(3)also benefited the agglomeration of iron particles and the slag–metal separation by decreasing the viscosity of the slag.Thus,Na_(2)CO_(3)assisted carbothermic reduction is a promising method for treating VTC at low temperatures. | Luming Chen Yulan Zhen Guohua Zhang Desheng Chen Lina Wang Hongxin Zhao Fancheng Meng Tao Qi | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，2： | 5 |
| 4 | shRNA-mediated Slc38a1 silencing inhibits migration, but not invasiveness of human pancreatic cancer cells显示文摘Objective:Early metastasis is a major biological feature of pancreatic cancer.The current study examined whether silencing Slc38a1,a gene involved in energy metabolism,using short hairpin RNA(shRNA)could inhibit the growth,migration,and invasiveness of pancreatic cancer cells.Methods:A series of Slc38a1 shRNAs were designed and cloned into the pGPU6/GFP/Neo vectors.An shRNA with the most efficacious inhibitory action on SCL38A1 expression(65%inhibition)upon screening in DH5αbacteria was used to transfect SW1990 human pancreatic cancer cells.Cell growth,migration,and invasiveness were examined using cell counting kit-8,Boyden chamber without and with Matrigel,respectively.Results:Transfection of SW1990 cells with the SLCs38A1 shRNA significantly decreased the proliferation(P<0.0001)and migratory potential(by 46.7%,P=0.0399)of the cancer cells.Invasiveness,however,was not affected.Conclusions:Inhibiting Slc38a1 using shRNA technology could decrease the growth and migration of representative pancreatic cancer cells.However,the fact that invasiveness was not affected suggested that SLC38A1 is unlikely to be responsible for early metastasis. | Jing Xie Zhen Chen Luming Liu Ping Li Xiaoyan Zhu Huifeng Gao Zhiqiang Meng | 2013 | Chinese Journal of Cancer Research2013，25，5： | 5 |
| 5 | Deep brain–machine interfaces:sensing and modulating the human deep brain显示文摘Different from conventional brain–machine interfaces that focus more on decoding the cerebral cortex,deep brain–machine interfaces enable interactions between external machines and deep brain structures.They sense and modulate deep brain neural activities,aiming at function restoration,device control and therapeutic improvements.In this article,we provide an overview of multiple deep brain recording and stimulation techniques that can serve as deep brain–machine interfaces.We highlight two widely used interface technologies,namely deep brain stimulation and stereotactic electroencephalography,for technical trends,clinical applications and brain connectivity research.We discuss the potential to develop closed-loop deep brain–machine interfaces and achieve more effective and applicable systems for the treatment of neurological and psychiatric disorders. | Yanan Sui Huiling Yu Chen Zhang Yue Chen Changqing Jiang Luming Li | 2022 | National Science Review2022，9，10： | 3 |
| 6 | Progress in the development of a fully implantable brain–computer interface:the potential of sensing-enabled neurostimulators显示文摘With the advances in neurophysiological recording technology and active implantable medical device development,sensing-enabled neurostimulators have become an emerging technology of the fully implantable brain–computer interface(BCI).These implantable neurostimulators are designed for deep brain stimulation(DBS),a well-established treatment for movement disorders and a promising treatment for psychiatric disorders.By integrating neural recording,sensing-enabled neurostimulators can sample local field potentials(LFPs)through the available contacts of the DBS electrode while delivering stimulation. | Yue Chen Guokun Zhang Linxiao Guan Chen Gong Bozhi Ma Hongwei Hao Luming Li | 2022 | National Science Review2022，9，10： | 3 |
| 7 | Ultrahigh rate capability of 1D/2D polyaniline/titanium carbide(MXene)nanohybrid for advanced asymmetric supercapacitors显示文摘High energy density and enhanced rate capability are highly sought-after for supercapacitors in today's mobile world.In this work,polyaniline/titanium carbide(MXene)(PANI/Ti3C2Tx)nanohybrid is synthesized through a facile and cost-effective self-assembly of.one-dimensional(10)PANI nanofibers and two-dimensional(20)Ti3C2Tx nanosheets.PANl!Ti3C2Tx delivers greatly improved specific capacitance,ultrahigh rate capability(67%capacitance retention from 1 to 100 A·g^(-1))as well as good cycle stability.Electrochemical kinetic analysis reveals that PANI/Ti3C2Tx is featured with surface capacitance-dominated process and has a quasi-reversible kinetics at high scan rates,giving rise to an ultrahigh rate capability.By using PANl!Ti3C2Tx as positive electrode,an 1.8 V aqueous asymmetric supercapacitor(ASC)is successfully assembled,showing a maximum energy density of 50.8 Wh·kg^(-1)·(at 0.9 kW-kg-1)and a power density of 18 kW·kg^(-1)(at 26 Wh·kg^(-1)).Moreover,an 3.0 V organic ASC is also elaborately fabricated,·by using PANI/Ti3C2Tx,achieving an ultrahigh energy density of 67.2 Wh·kg^(-1)(at 1.5 kW·kg^(-1))and a power density of 30 kW·kg^(-1)·(at 26.8 Wh·kg^(-1)).The present work not only improves fundamental understanding of the structure-property relationship towards ultrahigh rate capability electrode materials,but also provides valuable guideline for the rational design of high-performance:energy storage devices with both high energy and power densities. | Jinhua Zhou Qi Kang Shuchi Xu Xiaoge Li Cong Liu Lu Ni Ningna Chen Chunliang Lu Xizhang Wang Luming Peng Xuefeng Guo Weiping Ding Wenhua Hou | 2022 | Nano Research2022，15，1： | 2 |
| 8 | Chronically monitoring the deep brain rhythms: from stimulation to recording显示文摘Humans have never stopped exploring their brains,one of the most complex systems in nature.A thorough understanding of the brain is the ultimate challenge for neuroscientists.As there is a rapid increase in the aging populations and the number of brain disorders,researchers are much more eager to clarify how the billions of | Xing Qian Yue Chen Bozhi Ma Hongwei Hao Luming Li | 2016 | Science Bulletin2016，61，19： | 2 |
| 9 | Hierarchically porous Fe/N/S/C nanospheres with high-content of Fe-Nx for enhanced ORR and Zn-air battery performance显示文摘Heteroatom-doped carbon-based transition-metal single-atom catalysts(SACs) are promising electrocatalysts for oxygen reduction reaction(ORR). Herein, with the aid of hierarchically porous silica as hard template, a facile and general melting perfusion and mesopore-confined pyrolysis method was reported to prepare single-atomic Fe/N–S-doped carbon catalyst(FeNx/NC-S) with hierarchically porous structure and well-defined morphology. The FeNx/NC-S exhibited excellent ORR activity with a half-wave potential(E_(1/2)) of 0.92 V, and a lower overpotential of 320 mV at a current density of 10 mA cm^(-2)for OER under alkaline condition. The remarkable electrocatalysis performance can be attributed to the hierarchically porous carbon nanospheres with S doping and high content of Fe-Nx sites(up to 3.7 wt% of Fe), resulting from the nano-confinement effect of the hierarchically porous silica spheres(NKM-5) during the pyrolysis process. The rechargeable Zn-air battery with FeNx/NC-S as a cathode catalyst demonstrated a superior power density of 194.5 mW cm-2charge–discharge stability. This work highlights a new avenue to design advanced SACs for efficient sustainable energy storage and conversion. | Luming Wu Ruge Zhao Guo Du Huan Wang Machuan Hou Wei Zhang Pingchuan Sun Tiehong Chen | 2023 | Green Energy & Environment2023，8，6： | 1 |
| 10 | Conservative sehemes for the symmetric regularized long wave equations 显示文摘 | Wang Tingchun Zhang Luming Chen Fangqi | 2007 | Applied Mathematics and Computation2007，190，： | 1 |
| 11 | An integrated spectroscopic strategy to trace the geographical origins of emblic medicines: Application for the quality assessment of natural medicines显示文摘Emblic medicine is a popular natural source in the world due to its outstanding healthcare and therapeutic functions.Our preliminary results indicated that the quality of emblic medicines might have an apparent regional variation.A rapid and effective geographical traceability system has not been designed yet.To trace the geographical origins so that their quality can be controlled,an integrated spectroscopic strategy including spectral pretreatment,outlier diagnosis,feature selection,data fusion,and machine learning algorithm was proposed.A featured data matrix(245220)was successfully generated,and a carefully adjusted RF machine learning algorithm was utilized to develop the geographical traceability model.The results demonstrate that the proposed strategy is effective and can be generalized.Sensitivity(SEN),specificity(SPE)and accuracy(ACC)of 97.65%,99.85%and 97.63%for the calibrated set,as well as 100.00%predictive efficiency,were obtained using this spectroscopic analysis strategy.Our study has created an integrated analysis process for multiple spectral data,which can achieve a rapid,nondestructive and green quality detection for emblic medicines originating from seventeen geographical origins. | Luming Qi Furong Zhong Yang Chen Shengnan Mao Zhuyun Yan Yuntong Ma | 2020 | Journal of Pharmaceutical Analysis2020，10，4： | 1 |
| 12 | Nest-type NCM ■ Pt/C with oxygen capture character as advanced electrocatalyst for oxygen reduction reaction显示文摘A unique nest-type catalyst has been designed with a nest of oxygen capture surrounding catalytic Pt centers, which shows much promoted performance, on the base of Pt/C catalyst, for oxygen reduction reaction(ORR). The nest is constructed with nitrogen-doped carbon matrix(NCM), derived from the controlled carbonization of PANI precursor, to cover Pt/C catalyst. The unique structure of the catalyst(denoted as NCM■ Pt/C) has many merits. Firstly, it can capture oxygen both in air and in acidic electrolyte. Compared with naked Pt/C, it is found that, in air, the oxygen concentration within the porous nest of NCM surrounding Pt/C particles is ~13 times higher than atmospheric oxygen concentration and, in acidic electrolyte, the concentration of activated oxygen over the catalyst NCM■ Pt/C rise to~1.9 times. Secondly, the NCM nest offers a special electronic modulation on Pt centers toward modified ORR kinetics and then catalytic performances. With these merits, compared with Pt/C, the NCM■ Pt/C catalyst shows 3.2 times higher turnover frequency value and 2.9 times enhanced specific activity for ORR with half-wave potential at 0.894 V. After 50,000 sweeping cycles, the NCM■ Pt/C catalyst retains~66% mass activity and still has advantages over the fresh Pt/C catalyst. We envision that the nest-type catalyst provides a new idea for progress of practical Pt/C ORR catalyst. | Teng Chen Yida Xu Deming Meng Xuefeng Guo Yan Zhu Luming Peng Jianqiang Hu Weiping Ding | 2022 | Journal of Energy Chemistry2022，31，8： | 1 |
| 13 | The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasL显示文摘 | Peng Wang Liping Zhuang Juan Zhang Jie Fan Jianmin Luo Hao Chen Kun Wang Luming Liu Zhen Chen Zhiqiang Meng | 2013 | Molecular Oncology2013，，3： | 1 |
| 14 | Conservative difference scheme based on numerical analysis for nonlinear SchrSdinger equation with wave operator显示文摘 | Wang Tingchun Zhang Luming Chen Fangqi | 2006 | Trans Nanjing Univ of Aero &: Astron2006，23，2： | 1 |
| 15 | Magnetic field aberration induced by cycle stress 显示文摘 | Yang En Li Luming Chen Xing | 2007 | Journal of Magnetism and Magnetic Materials2007，312，1： | 1 |
| 16 | MicroRNA 23b Regulates Autophagy Associated With Radioresistance of Pancreatic Cancer Cells显示文摘 | Peng Wang Juan Zhang Li Zhang Zhengfei Zhu Jie Fan Lianyu Chen Liping Zhuang Jianmin Luo Hao Chen Luming Liu Zhen Chen Zhiqiang Meng | 2013 | Gastroenterology2013，，5： | 1 |
| 17 | 靶向肾癌中的E3连接酶接头蛋白SPOP的小分子抑制剂显示文摘近年来肾癌发病率上升幅度在恶性肿瘤中排名第一。临床治疗表明,肾癌对放疗和化疗均不敏感,以索拉非尼和舒尼替尼为代表的靶向抗肿瘤药物是晚期肾癌的一线治疗药物,但对转移性肾癌的疗效十分有限,并且容易产生耐药。因此,发现并确证治疗肾癌特异性药物作用新靶标是一项十分紧迫并意义重大的任务。 | Zhong-Qiang Guo Tong Zheng Baoen Chen Cheng Luo Sisheng Ouyang Shouzhe Gong Jiafei Li Liu-Liang Mao Fulin Lian Yong Yang Yue Huang Li Li Jing Lu Bidong Zhang Luming Zhou Hong Ding Zhiwei Gao Liqun Zhou Guoqiang Li Ran Zhou Ke Chen Jingqiu Liu Yi Wen Likun Gong Yuwen Ke Shang-Dong Yang Xiao-Bo Qiu Naixia Zhang Jin Ren Dafang Zhong 杨财广 刘江 蒋华良 | 2017 | 科学新闻2017，19，4： | 1 |
| 18 | Effect of Barium Sulfate Nanoparticles on Mechanical Properties and Crystallization Behaviour of HDPE显示文摘 | Chen Xiaolei Wang Luming Shi Jiangao Shi Hang Liu Yongli | 2010 | Polymers & Polymer Composites2010，，3： | 1 |
| 19 | Magnetic field aberration induced by cycle stress显示文摘 | Yang En Li luming Chen Xing | 2006 | Journal of Magnetism and Magnetic Materials2006，，1： | 1 |
| 20 | Magnetic field aberration induced by cycle stress显示文摘 | YANG En LI Luming CHEN Xing | 2007 | Journal of Magnetism and Magnetic Materials2007，312，1： | 1 |
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