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| 1 | Risk assessment and validation of flood disaster based on fuzzy mathematics显示文摘Floods often take place around rivers and plains,which indicates a higher risk of flooding in these areas.This paper adopts fuzzy comprehensive assessment(FCA),simple fuzzy classification(SFC),and the fuzzy similarity method(FSM) to assess flood disaster risk in Kelantan,Malaysia.Validation data,such as the flooded area,paddy area,urban area,residential area,and refuges,were overlaid to validate and analyze the accuracy of flood disaster risk.The results show that(1) 70-75% of flooded areas lie within the higher and high-est risk zones,which shows an effective assessment accuracy;(2) paddy,built-up,and residential areas concentrated in the higher and highest risk zones are more likely to be destroyed by flood disasters;(3) 200-225 refuges in the higher and highest risk zones account for around 50% of all refuges,which means that more refuges should be built in the higher and highest risk zones to meet the accommodation requirement;(4) three methods proved to be feasible and effective in evaluating flood disaster risk,among which FCA is more suitable for the study area than the two other methods. | Weiguo Jiang Lei Deng Luyao Chen Jianjun Wu Jing Li | 2009 | Progress in Natural Science:Materials International2009，19，10： | 35 |
| 2 | Distant eQTLs and Non-coding Sequences Play Critical Roles in Regulating Gene Expression and Quantitative Trait Variation in Maize显示文摘 | Haijun Liu Xin Luo Luyao Niu Yingjie Xiao Lu Chen Jie Liu Xiaqing Wang Minliang Jin Wenqiang Li Qinghua Zhang Jianbing Yan | 2017 | Molecular Plant2017，10，3： | 13 |
| 3 | Sintilimab versus docetaxel as second-line treatment in advanced or metastatic squamous non-small-cell lung cancer:an open-label,randomized controlled phase 3 trial(ORIENT-3)显示文摘Background:Treatment options for Chinese patients with locally advanced or metastatic squamous-cell non-small-cell lung cancer(sqNSCLC)after failure of first-line chemotherapy are limited.This study(ORIENT-3)aimed to evaluate the efficacy and safety of sintilimab versus docetaxel as second-line treatment in patients with locally advanced or metastatic sqNSCLC.Methods:ORIENT-3 was an open-label,multicenter,randomized controlled phase 3 trial that recruited patients with stage IIIB/IIIC/IV sqNSCLC after failure with first-line platinum-based chemotherapy.Patients were randomized in a 1:1 ratio to receive either 200 mg of sintilimab or 75 mg/m^(2) of docetaxel intravenously every 3 weeks,stratified by the Eastern Cooperative Oncology Group performance status.The primary endpoint was overall survival(OS)in the full analysis set(FAS).Secondary endpoints included progression-free survival(PFS),objective response rate(ORR),disease control rate(DCR),duration of response(DoR)and safety.Results:Between August 25,2017,and November 7,2018,290 patients were randomized.For FAS,10 patients fromthe docetaxel armwere excluded.Themedian OS was 11.79(n=145;95%confidence interval[CI],10.28-15.57)months with sintilimab versus 8.25(n=135;95%CI,6.47-9.82)months with docetaxel(hazard ratio[HR]:0.74;95%CI,0.56-0.96;P=0.025).Sintilimab treatment significantly prolonged PFS(median 4.30 vs.2.79 months;HR:0.52;95%CI,0.39-0.68;P<0.001)and showed higher ORR(25.50%vs.2.20%,P<0.001)and DCR(65.50%vs.37.80%,P<0.001)than the docetaxel arm.The median DoRwas 12.45(95%CI,4.86-25.33)months in the sintilimab arm and 4.14(95%CI,1.41-7.23)months in the docetaxel arm(P=0.045).Treatment-related adverse events of grade≥3were reported in 26(18.1%)patients in the sintilimab arm and 47(36.2%)patients in the docetaxel arm.Exploratory biomarker analysis showed potential predictive values of expression levels of two transcription factors,including OVOL2(HR:0.35;P<0.001)and CTCF(HR:3.50;P<0.001),for sintilimab treatment.Conclusions:Compared with docetaxel,sintilimab significantly improved the OS,PFS,and ORR of Chinese patients with previously treated locally advanced or metastatic sqNSCLC. | Yuankai Shi Lin Wu Xinmin Yu Puyuan Xing Yan Wang Jianying Zhou Airong Wang Jianhua Shi Yi Hu Ziping Wang Guangyu An Yong Fang Sanyuan Sun Caicun Zhou Changli Wang Feng Ye Xingya Li Junye Wang Mengzhao Wang Yunpeng Liu Yanqiu Zhao Ying Yuan Jifeng Feng Zhendong Chen Jindong Shi Tao Sun Gang Wu Yongqian Shu Qisen Guo Yi Zhang Yong Song Shucai Zhang Yuan Chen Wei Li Hongrui Niu Wenwei Hu Lijun Wang Jianan Huang Yang Zhang Ying Cheng Zhengdong Wu Bo Peng Jiya Sun Christoph Mancao Yanqi Wang Luyao Sun | 2022 | Cancer Communications2022，42，12： | 8 |
| 4 | Unsteady aerodynamic characteristics of a horizontal wind turbine under yaw and dynamic yawing显示文摘Horizontal axis wind turbine(HAWT)often works under yaw due to the stochastic variation of wind direction.Yaw also can be used as one of control methods for load reduction and wake redirection of HAWT.Thus,the aerodynamic performance under yaw is very important to the design of HAWT.For further insight into the highly unsteady characteristics aerodynamics of HAWT under yaw,this paper investigates the unsteady variations of the aerodynamic performance of a small wind turbine under static yawed and yawing process with sliding grid method,as well as the there-dimensional effect on the unsteady characteristics,using unsteady Reynolds-averaged Navier-Stokes(URANS)simulations.The simulation results are validated with experimental data and blade element momentum(BEM)results.The comparisons show that the CFD results have better agreement with the experimental data than both BEM results.The wind turbine power decreases according to a cosine law with the increase of yaw angle.The torque under yaw shows lower frequency fluctuations than the non-yawed condition due to velocity component of rotation and the influence of spinner.Dynamic yawing causes larger fluctuate than static yaw,and the reason is analyzed.The aerodynamic fluctuation becomes more prominent in the retreating side than that in the advancing side for dynamic yawing case.Variations of effective angle of attack and aerodynamic forces along the blade span are analyzed.The biggest loading position moves from middle span to outer span with the increase of yaw angle.Three-dimensional stall effect presents load fluctuations at the inner board of blade,and becomes stronger with the increase of yaw angle. | Zhaoliang Ye Xiaodong Wang Ziwen Chen Luyao Wang | 2020 | Acta Mechanica Sinica2020，36，2： | 8 |
| 5 | The calcium-dependent protein kinase ZmCDPK7 functions in heat-stress tolerance in maize显示文摘Global warming poses a serious threat to crops.Calcium-dependent protein kinases(CDPKs)/CPKs play vital roles in plant stress responses,but their exact roles in plant thermotolerance remains elusive.Here,we explored the roles of heat-induced ZmCDPK7 in thermotolerance in maize.ZmCDPK7-overexpressing maize plants displayed higher thermotolerance,photosynthetic rates,and antioxidant enzyme activity but lower H2 O2 and malondialdehyde(MDA)contents than wild-type plants under heat stress.ZmCDPK7-knockdown plants displayed the opposite patterns.ZmCDPK7 is attached to the plasma membrane but can translocate to the cytosol under heat stress.ZmCDPK7 interacts with the small heat shock protein sHSP17.4,phosphorylates sHSP17.4 at Ser-44 and the respiratory burst oxidase homolog RBOHB at Ser-99,and up regulates their expression.Site-directed mutagenesis of sHSP17.4 to generate a Ser-44-Ala substitution reduced ZmCDPK7’s enhancement of catalase activity but enhanced ZmCDPK7’s suppression of MDA accumulation in heat-stressed maize protoplasts.sHSP17.4,ZmCDPK7,and RBOHB were less strongly upregulated in response to heat stress in the abscisic acid-deficient mutant vp5 versus the wild type.Pretreatment with an RBOH inhibitor suppressed sHSP17.4 and ZmCDPK7 expression.Therefore,abscisic acid-induced ZmCDPK7 functions both upstream and downstream of RBOH and participates in thermotolerance in maize by mediating the phosphorylation of sHSP17.4,which might be essential for its chaperone function. | Yulong Zhao Hanwei Du Yankai Wang Huali Wang Shaoyu Yang Chaohai Li Ning Chen Hao Yang Yihao Zhang Yulin Zhu Luyao Yang Xiuli Hu | 2021 | Journal of Integrative Plant Biology2021，63，3： | 6 |
| 6 | Development of Cryogenic Disinfectants Using in-18℃and-40℃Environments—Worldwide,2021显示文摘Introduction:Since the outbreak of coronavirus disease 2019(COVID-19)in Beijing Xinfadi Wholesale Market,a series of COVID-19 outbreaks has indicated the threat of transmission due to outer surfaces of objects under low temperatures.Therefore,2 kinds of chlorine-containing disinfectants for−18℃and−40℃were developed in order to solve the problem of low temperature disinfection.Methods:The properties of two cryogenic disinfectants were evaluated by low-temperature test.Staphylococcus aureus and Escherichia coli were used as two indicator microorganisms to evaluate the effects of the two cryogenic disinfectants in the laboratory and field tests according to Technical Specifications for Disinfection(2002 version)and Test method for bactericidal effect of disinfectants in laboratory(GB/T 38502-2020).Results:Two disinfectants could remain in the liquid state at−18℃or−40℃in 72 hours without crystallization and precipitation,and the average log values of microbial reduction before and after disinfection(the average killing log value)both on Staphylococcus aureus and Escherichia coli were>3 in the laboratory and field tests.Discussion:The results showed that these two disinfectants remained functional at low temperature to disinfect the packaging of imported cold chain food and surrounding packaging to prevent transmission of COVID-19 from material to people. | Huihui Sun Hongyang Duan Wei Zhang Chen Liang Luyao Li Yuan Lyu Yanyan Chen Jin Shen Liubo Zhang | 2021 | China CDC weekly2021，3，13： | 4 |
| 7 | Spatial and Temporal Pattern of Urban Smart Development in China and Its Driving Mechanism显示文摘Smart urban development is an inevitable choice, and is essential to overall strength improvement. It is important to explore an urban smart development path which unites smart growth with driving shrinkage perfectly in forming scientific and sustainable development concept and responding to new normal strategic opportunities. Based on statistic data of 294 prefecture-level cities and above in China from 2000 to 2015, we analyzed spatial and temporal evolution of urban smart development in China by constructing a dynamic fitting model of urban land expansion, population growth, and economic development as well as the coefficient of variation of urban smart development(CVSD). Further efforts were then made to consider differential distribution regularity of urban smart development so as to understand the driving mechanisms of heterogeneous classification of urban smart development in China from different scales and scale variation. Our results indicate that: 1) the disordered growth tendency of urban cities in China is overall well controlled in the middle, and late research and it mainly presented a doublet coexistence of shrinkage disordered cities and smart developing cities. It is particularly obvious that Northeast China and East China have regarded shrinkage disordered cities and smart developing cities as main development tendency separately. 2) Areas with basic stability and relative variation were relatively dispersed across the time period, but the proportion was far beyond areas with significant variation. It demonstrates a relative equilibrium spatial and temporal differential evolution pattern of prefecture-level cities and above in China, except for Tongling, Lanzhou and Chaoyang. 3) prefecture-level cities and above in China are mostly characterized by shrinkage disordered and smart development classification under the background of different scale and scale variation from 2000–2015; however, the spatial resonance relation is not obvious. 4) There are many interaction factors forming an important driving mechanism in developing the spatial and temporal pattern of urban smart development in China, including natural geographical factors, industrial structure adjustment, human capital radiation, regional traffic accessibility, and government decision-making intervention. | CHEN Xiaohong WEI Luyao ZHANG Haifeng | 2018 | Chinese Geographical Science2018，28，4： | 3 |
| 8 | Astragaloside Ⅳ suppresses post-ischemic natural killer cell infiltration and activation in the brain:involvement of histone deacetylase inhibition显示文摘Natural killer(NK)cells,a type of cytotoxic lymphocytes,can infiltrate into ischemic brain and exacerbate neuronal cell death.Astragaloside Ⅳ(ASIV)is the major bioactive ingredient of Astragalus membranaceus,a Chinese herbal medicine,and possesses potent immunomodulatory and neuroprotective properties.This study investigated the effects of ASIV on post-ischemic brain infiltration and activation of NK cells.ASIV reduced brain infarction and alleviated functional deficits in MCAO rats,and these beneficial effects persisted for at least 7 days.Abundant NK cells infiltrated into the ischemic hemisphere on day 1 after brain ischemia,and this infiltration was suppressed by ASIV.Strikingly,ASIV reversed NK cell deficiency in the spleen and blood after brain ischemia.ASIV inhibited astrocyte-derived CCL2 upregulation and reduced CCR2+NK cell levels in the ischemic brain.Meanwhile,ASIV attenuated NK cell activating receptor NKG2D levels and reduced interferon-γproduction.ASIV restored acetylation of histone H3 and the p65 subunit of nuclear factor-κB in the ischemic brain,suggesting inhibition of histone deacetylase(HDAC).Simultaneously,ASIV prevented p65 nuclear translocation.The effects of ASIV on reducing CCL2 production,restoring acetylated p65 levels and preventing p65 nuclear translocation were mimicked by valproate,an HDAC inhibitor,in astrocytes subjected to oxygen-glucose deprivation.Our findings suggest that ASIV inhibits post-ischemic NK cell brain infiltration and activation and reverses NK cell deficiency in the periphery,which together contribute to the beneficial effects of ASIV against brain ischemia.Furthermore,ASIV’s effects on suppressing NK cell brain infiltration and activation may involve HDAC inhibition. | Baokai Dou Shichun Li Luyao Wei Lixin Wang Shiguo Zhu Zhengtao Wang Zunji Ke Kaixian Chen Zhifei Wang | 2021 | Frontiers of Medicine2021，15，1： | 3 |
| 9 | Investigation of PM_(2.5) pollution during COVID-19 pandemic in Guangzhou,China显示文摘The COVID-19 pandemic has raised awareness about various environmental issues,includ-ing PM_(2.5) pollution.Here,PM_(2.5) pollution during the COVID-19 lockdown was traced and an-alyzed to clarify the sources and factors influencing PM_(2.5) in Guangzhou,with an emphasis on heavy pollution.The lockdown led to large reductions in industrial and traffic emissions,which significantly reduced PM_(2.5) concentrations in Guangzhou.Interestingly,the trend of PM_(2.5) concentrations was not consistent with traffic and industrial emissions,as minimum concentrations were observed in the fourth period(3/01-3/31,22.45 μg/m^(3))of the lockdown.However,the concentrations of other gaseous pollutants,e.g.,SO_(2),NO_(2) and CO,were corre-lated with industrial and traffic emissions,and the lowest values were noticed in the sec-ond period(1/24-2/0_(3))of the lockdown.Meteorological correlation analysis revealed that the decreased PM_(2.5) concentrations during COVID-19 can be mainly attributed to decreased in-dustrial and traffic emissions rather than meteorological conditions.When meteorological factors were included in the PM_(2.5) composition and backward trajectory analyses,we found that long-distance transportation and secondary pollution offset the reduction of primary emissions in the second and third stages of the pandemic.Notably,industrial PM_(2.5) emis-sions from western,southern and southeastern Guangzhou play an important role in the formation of heavy pollution events.Our results not only verify the importance of control-ling traffic and industrial emissions,but also provide targets for further improvements in PM_(2.5) pollution. | Luyao Wen Chun Yang Xiaoliang Liao Yanhao Zhang Xuyang Chai Wenjun Gao Shulin Guo Yinglei Bi Suk-Ying Tsang Zhi-Feng Chen Zenghua Qi Zongwei Cai | 2022 | Journal of Environmental Sciences2022，34，5： | 2 |
| 10 | Modulation of Beta Oscillations for Implicit Motor Timing in Primate Sensorimotor Cortex during Movement Preparation显示文摘Motor timing is an important part of sensorimotor control. Previous studies have shown that beta oscillations embody the process of temporal perception in explicit timing tasks. In contrast, studies focusing on beta oscillations in implicit timing tasks are lacking. In this study, we set up an implicit motor timing task and found a modulation pattern of beta oscillations with temporal perception during movement preparation. We trained two macaques in a repetitive visually-guided reach-to-grasp task with different holding intervals. Spikes and local field potentials were recorded from microelectrode arrays in the primary motor cortex, primary somatosensory cortex, and posterior parietal cortex. We analyzed the association between beta oscillations and temporal interval in fixedduration experiments(500 ms as the Short Group and1500 ms as the Long Group) and random-duration experiments(500 ms to 1500 ms). The results showed that the peak beta frequencies in both experiments ranged from15 Hz to 25 Hz. The beta power was higher during the hold period than the movement(reach and grasp) period.Further, in the fixed-duration experiments, the mean poweras well as the maximum rate of change of beta power in the first 300 ms were higher in the Short Group than in the Long Group when aligned with the Center Hit event. In contrast, in the random-duration experiments, the corresponding values showed no statistical differences among groups. The peak latency of beta power was shorter in the Short Group than in the Long Group in the fixed-duration experiments, while no consistent modulation pattern was found in the random-duration experiments. These results indicate that beta oscillations can modulate with temporal interval in their power mode. The synchronization period of beta power could reflect the cognitive set maintaining working memory of the temporal structure and attention. | Hongji Sun Xuan Ma Liya Tang Jiuqi Han Yuwei Zhao Xuejiao Xu Lubin Wang Peng Zhang Luyao Chen Jin Zhou Changyong Wang | 2019 | Neuroscience Bulletin2019，35，5： | 2 |
| 11 | Salt stress-induced changes in soil metabolites promote cadmium transport into wheat tissues显示文摘Soil salinity is known to improve cadmium(Cd)mobility,especially in arid soils.However,the mechanisms involved in how salt stress-associated metabolic profiles participate in mediating Cd transport in the soil-plant system remain poorly understood.This study was designed to investigate the effects of salinity-induced changes in soil metabolites on Cd bioavailability.Sodium salts in different combinations according to molar ratio(NaCl:Na_(2)SO_(4)=1:1;NaCl:Na_(2)SO_(4):NaHCO_(3)=1:2:1;NaCl:Na_(2)SO_(4):NaHCO_(3):Na_(2)CO_(3)=1:9:9:1;NaCl:Na_(2)SO_(4):NaHCO_(3):Na_(2)CO_(3)=1:1:1:1)were applied to the Cd-contaminated soils,which increased soil Cd availability by 22.36%and the Cd content in wheat grains by 36.61%,compared to the control.Salt stress resulted in soil metabolic reprogramming,which might explain the decreased growth of wheat plants and increased Cd transport from the soil into wheat tissues.For example,down-regulation of starch and sucrose metabolism reduced the production of sugars,which adversely affected growth;up-regulation of fatty acid metabolism allowed wheat plants to maintain a normal intracellular environment under saline conditions;up-regulation of the tricarboxylic acid(TCA)cycle was triggered,causing an increase in organic acid synthesis and the accumulation of organic acids,which facilitated the migration of soil Cd into wheat tissues.In summary,salt stress can facilitate Cd transport into wheat tissues by the direct effect of salt-based ions and the combined effect of altered soil physicochemical properties and soil metabolic profiles in Cd-contaminated soils. | Lifu Wang Luyao Qin Xiaoyi Sun Shuwen Zhao Lei Yu Shibao Chen Meng Wang | 2023 | Journal of Environmental Sciences2023，，5： | 1 |
| 12 | Application of Refactoring and Design Pattern in Land Information System Development显示文摘土地信息系统的不停的变化问题能通过重新分解和设计模式被解决。为了在开发再使用软件的土地信息系统支持设计模式和重新分解的方法的实现,设计,适用重新分解在土地信息系统开发的模式被讨论的到抽象工厂和装饰者设计的方法。 | CHEN Luyao YUE Jianwei JIANG Weiguo LI Jing CHEN Yunhao | 2007 | Geo-Spatial Information Science2007，10，4： | 1 |
| 13 | Low-Temperature Aging Provides 22% E cient Bromine-Free and Passivation Layer-Free Planar Perovskite Solar Cells显示文摘Previous reports of formamidinium/methylamine(FAMA)-mixed halide perovskite solar cells have focused mainly on controlling the morphology of the perovskite film and its interface—for example,through the inclusion of bromine and surface passivation.In this paper,we describe a new processing pathway for the growth of a high-quality bromine-free FAMAPbI3 halide perovskites via the control of intermediate phase.Through low-temperature aging growth(LTAG)of a freshly deposited perovskite film,α-phase perovskites can be seeded in the intermediate phase and,at the same time,prevent beta-phase perovskite to nucleate.After postannealing,large grain-size perovskites with significantly reduced PbI2 presence on the surface can be obtained,thereby eliminating the need of additional surface passivation step.Our pristine LTAG-treated solar cells could provide PCEs of greater than 22%without elaborate use of bromine or an additional passivation layer.More importantly,when using this LTAG process,the growth of the pure alpha-phase FAMAPbI3 was highly reproducible. | Xin Wang Luyao Wang Tong Shan Shibing Leng Hongliang Zhong Qinye Bao Zheng-Hong Lu Lin-Long Deng Chun-Chao Chen | 2020 | Nano-Micro Letters2020，12，7： | 1 |
| 14 | Preparation and application of mesoporous core-shell nanosilica using leucine derivative as template in effective drug delivery显示文摘Core-shell structured mesoporous silica nanoparticles have been firstly synthesized with the new template from L-leucine methyl ester hydrochloride(H-Leu-OMe·HCl).LMSNs were characterized by transmission electron microscopy(TEM),nitrogen adsorption/desorption,and small-angle X-ray diffraction(SAXRD),demonstrating a well-ordered mesostructure.After loading doxorubicin hydrochloride(Dox) into pores,considerable loading capacity of 30.5% and favorable cumulative release amount were obtained.MTT assay suggested that Dox-loaded LMSNs demonstrated great promise to anti-tumor.The use of MSNs with the synthesized template,as a drug delivery carrier,will exte nd the pharmaceutical applications of silica materials. | Wei Zhang Qiming Kan Lu Chen Luyao Xie Mingshu Cui Ziyue Xi Yanru Xi Sanming Li Lu Xu | 2020 | Chinese Chemical Letters2020，31，5： | 1 |
| 15 | Variation of mechanical properties and microstructure of hot-rolled AA2099 Al-Li alloy induced by the precipitation during preheating process显示文摘Preheating is the first step for thermal-mechanical processing of the materials. Several preheating schedules were designed based on industrial manufacturing to explore their effect on the microstructure and mechanical properties of AA2099 Al-Li alloy during the following hot rolling. The results show that the mechanical properties of as-rolled sheets are quite sensitive to preheating. Various types of secondary phases, including δ', T1 and T2 phases, were precipitated during the heating process. The difference among precipitates is the main reason to induce the variation of mechanical properties for as-rolled sheets. A rapid heating rate gave rise to the precipitation of δ' phase, which largely promoted yield stress and ultimate tensile strength in as-rolled sheets. T1 phase was more favorable in the preheating with a holding period at 150–250 °C, which caused a moderated strain hardening behavior. Precipitates formed during preheating induced different slip behaviors in the following deformation. The coexistence of T1 and δ' phase could restrict planar slip, which inhibited the formation of the shear band. The difference in the activity of non-octahedral slips and planar slips determined the strain hardening effect, which should be the reason for the variation of mechanical properties of as-rolled sheets. | Fei Guo Weijiu Huang Xusheng Yang Haipeng Dong Hang Yu Qiuyu Chen Li Hu Luyao Jiang | 2022 | Journal of Materials Science & Technology2022，，15： | 1 |
| 16 | Hierarchical Hydrogels with Ordered Micro-Nano Structures for Cancer-on-a-Chip Construction显示文摘In the drug therapy of tumor,efficient and stable drug screening platforms are required since the drug efficacy varies individually.Here,inspired by the microstructures of hepatic lobules,in which hepatocytes obtain nutrients from both capillary vessel and the central vein,we present a novel hierarchical hydrogel system with ordered micro-nano structure for liver cancer-on-a-chip construction and drug screening.The hierarchical hydrogel system was fabricated by using pregel to fill and replicate selfassembled colloidal crystal arrays and microcolumn array template.Due to the synergistic effect of its interconnected micro-nano structures,the resultant system could not only precisely control the size of cell spheroids but also realize adequate nutrient supply of cell spheroids.We have demonstrated that by integrating the hierarchical hydrogel system into a multichannel concentration gradients microfluidic chip,a functional liver cancer-on-a-chip could be constructed for high-throughput drug screening with good repeatability and high accuracy.These results indicated that the hierarchical hydrogel system and its derived liver cancer-on-a-chip are ideal platforms for drug screening and have great application potential in the field of personalized medicine. | Luyao Zhu Changmin Shao Hanxu Chen Zhuoyue Chen Yuanjin Zhao | 2021 | Research2021，，1： | 1 |
| 17 | Epicatechin gallate prevents the de novo synthesis of fatty acid and the migration of prostate cancer cells显示文摘Lipid metabolism disorder caused by the upregulation of lipogenic genes is a typical feature of prostate cancer.The synthesis of fatty acids is enhanced to accelerate the development of prostate cancer and is considered as a potential therapeutic target.Epicatechin gallate,an active compound of green tea,has been reported to modulate lipid metabolism.In this research,the potential role of epicatechin gallate in prostate cancer cells was evaluated.The results indicated that epicatechin gallate downregulates the expression of acetyl-CoA carboxylase,ATP citrate lyase,and fatty acid synthase in prostate cancer cells and prostate xenograft tissues,suggesting that epicatechin gallate can inhibit de novo fatty acid synthesis.Moreover,epicatechin gallate significantly restrains the migration rather than the viability of prostate cancer cells.PI3K/AKT/mTOR signaling pathway,which exhibits regulatory effect on lipogenesis,is also inhibited under epicatechin gallate treatment,while pretreatment with AKT activator SC79 or mTOR activator MHY1485 blocks the inhibitory effect of epicatechin gallate on the expression of lipogenic genes and the migration of prostate cancer cells.In conclusion,this study revealed that epicatechin gallate impairs the synthesis of fatty acids via inhibition PI3K/AKT/mTOR signaling pathway and then attenuates the migration of prostate cancer cells. | Luyao Chen Yaping Guo Zixuan Wu Shuwu Zhao Zhaiyi Zhang Fang Zheng Likang Sun Zheng Hao Chen Xu Tao Wang Yanfei Peng | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 1 |
| 18 | Two birds with one stone:Construction of bifunctional-POSS hybridized boron-silicon ceramicized phenolic composites and its ablation behavior显示文摘To further enhance the ablation resistance properties of thermosetting phenolic resin matrix composites,in this work,bifunctional alkalic heptaphenyltrisilanol sodium salt polyhedral oligomeric silsesquioxane was utilized to catalyze the synthesis of boron phenolic resin and provide silicon source to obtain boron-silicon hybrid phenolic resin(BPOSSPR)with excellent ablative resistance.BPOSSPR possesses a low cur-ing activation energy(101.4 kJ/mol)and excellent thermal properties(initial decomposition temperature was 453.0℃and char yield at 1000℃was 72.7%).The mechanical and thermal insulation properties of carbon fiber reinforced BPOSSPR composites(CF/BPOSSPR)and high silica fiber reinforced BPOSSPR composites(HSF/BPOSSPR)are significantly enhanced.The linear ablation rate and mass ablation rate of CF/BPOSSPR are as low as 0.003 mm/s and 0.0354 g/s;those of HSF/BPOSSPR are 0.119 mm/s and 0.0264 g/s.The ablation-resistance mechanism of BPOSSPR composites is mainly due to the formation of ceramic thermal barrier layers under high temperature conditions,such as B_(2)O_(3),SiO_(2),borosilicate glass,SiC,which might play an effective role in protecting against heat flow erosion.As a result of these ex-cellent properties,the innovative heat shielding BPOSSPR composites could offer the ability to tolerate harsher environment in future aerospace applications. | Zhaoqi Niu Yi Xin Luyao Wang Shuai Shen Xiaoyan Ma Beixi Chen Chengzhi Wang Fang Chen Chengshuang Zhang Xiao Hou | 2023 | Journal of Materials Science & Technology2023，，10： | 0 |
| 19 | Hierarchical Hydrogels with Ordered Micro-Nano Structures for Cancer-on-a-Chip Construction显示文摘In the drug therapy of tumor,efficient and stable drug screening platforms are required since the drug efficacy varies individually.Here,inspired by the microstructures of hepatic lobules,in which hepatocytes obtain nutrients from both capillary vessel and the central vein,we present a novel hierarchical hydrogel system with ordered micro-nano structure for liver cancer-on-a-chip construction and drug screening.The hierarchical hydrogel system was fabricated by using pregel to fill and replicate self-assembled colloidal crystal arrays and microcolumn array template.Due to the synergistic effect of its interconnected micro-nano structures,the resultant system could not only precisely control the size of cell spheroids but also realize adequate nutrient supply of cell spheroids.We have demonstrated that by integrating the hierarchical hydrogel system into a multichannel concentration gradients microfluidic chip,a functional liver cancer-on-a-chip could be constructed for high-throughput drug screening with good repeatability and high accuracy.These results indicated that the hierarchical hydrogel system and its derived liver cancer-on-a-chip are ideal platforms for drug screening and have great application potential in the field of personalized medicine. | Luyao Zhu Changmin Shao Hanxu Chen Zhuoyue Chen Yuanjin Zhao | 2022 | Research2022，，2： | 0 |
| 20 | Preparation of hollow mesoporous silica nanorods for encapsulating and slowly releasing eugenol显示文摘Fragrances are widely used in many aspects of our lives.They cannot only make people happy,but also treat many diseases.However,excessively fast evaporation rate is one of the main obstacles to the use of spices.In this study,mesoporous silica nanorods(MSNRs)and hollow mesoporous silica nanorods(HMSNRs)were prepared to encapsulate eugenol.These two nano-fragrances were named eugenol@MSNRs and eugenol@HMSNRs,respectively.The morphologies,size,interior structures and pore performances of MSNRs and HMSNRs.Besides,the performances of encapsulation and fragrance release of eugenol@MSNRs and eugenol@HMSNRs were compared and analyzed.The results showed that eugenol@HMSNRs encapsulated more fragrance and were faster to encapsulate compared with eugenol@MSNRs.Both the release rates of eugenol from eugenol@MSNRs and eugenol@HMSNRs were slow.But the eugenol was released from eugenol@MSNRs more slowly. | Tianlu Zhang Zhiguo Lu Luyao Zhang Yan Li Jun Yang Jie Shen Jianze Wang Yunwei Niu Zuobing Xiao Lei Chen Xin Zhang | 2020 | Chinese Chemical Letters2020，31，12： | 0 |
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