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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Gastrodin inhibits neuroinflammation in rotenone-induced Parkinson's disease model rats显示文摘The present study showed that the latency of rats moving on a vertical grid was significantly prolonged,and the number of rats sliding down from the declined plane was increased remarkably,in rotenone-induced Parkinson's disease model rats compared with control rats.The moving latency recovered to normal levels,but the number of slides was significantly increased at 28 days after model establishment.The slope test is a meaningful approach to evaluate the symptoms of Parkinson's disease model rats treated with rotenone.In addition,loss of substantia nigral dopaminergic neurons in model rats was observed at 1 day after the model was established,and continued gradually at 14 and 28 days.The expression of tyrosine hydroxylase-positive cells was significantly increased in gastrodin-treated rats at 14 days.Significant numbers of activated microglia cells were observed in model rats at 14 and 28 days;treatment of rats with Madopar at 28 days suppressed microglial activation.Treatment of rats with gastrodin or Madopar at 28 days significantly reduced interleukin-1β expression.The loss of substantia nigral dopaminergic neurons paralleled the microglial activation in Parkinson's disease model rats treated with rotenone.The inflammatory factors tumor necrosis factor-α and interleukin-1β are involved in the substantia nigral damage.Gastrodin could protect dopaminergic neurons via inhibition of interleukin-1β expression and neuroinflammation in the substantia nigra. | Chun Li Xin Chen Nan Zhang Yangwen Song Yang Mu | 2012 | Neural Regeneration Research2012，7，5： | 15 |
| 3 | Modeling and Operation of the Power-to-Gas System for Renewables Integration: A Review显示文摘Power-to-Gas(P2G)plays an important role in enhancing large-scale renewable energy integration in power systems.As an emerging inter-disciplinary subject,P2G technology requires knowledge in electrochemistry,electrical engineering,thermodynamic engineering,chemical engineering and system engineering.Aiming at P2G modeling and operational problems concerning the research field of power systems and the energy internet,this paper briefly reviews the main technologies and application potentials of the P2G system,and makes systematic summaries of major progresses related to P2G’s integration into the power grid in a bottom-top manner,including the modeling of high/room-temperature electrolysis cells,steady-state/dynamic optimization control of the P2G system,P2G’s integrated model and operational strategies at the grid level.In the final part of this paper,suggestions are put forward on future research directions of P2G systems from the aspects of modeling and operational optimization. | Xuetao Xing Jin Lin Yonghua Song You Zhou Shujun Mu Qiang Hu | 2018 | CSEE Journal of Power and Energy Systems2018，4，2： | 15 |
| 4 | Hepatitis B surface antigen clearance in inactive hepatitis B surface antigen carriers treated with peginterferon alfa-2a显示文摘AIM: To examine the association between interferon(IFN) therapy and loss of hepatitis B surface antigen(HBs Ag) in inactive HBs Ag carriers. METHODS: This was a retrospective cohort study in inactive HBs Ag carriers, who were treatment-naive, with a serum HBs Ag level < 100 IU/m L and an undetectable hepatitis B virus(HBV) DNA level(< 100 IU/m L). All the 20 treated patients received subcutaneous PEG-IFN alfa-2a 180 μg/wk for 72 wk and were then followed for 24 wk. There were 40 untreated controls matched with 96 wk of observation. Serum HBs Ag, HBV DNA, and alanine aminotransferases were monitored every 3 mo in the treatment group and every 3-6 mo in the control group. RESULTS: Thirteen(65.0%) of 20 treated patients achieved HBs Ag loss, 12 of whom achieved HBs Ag seroconversion. Mean HBs Ag level in treated patients decreased to 6.69 ± 13.04 IU/m L after 24 wk of treatment from a baseline level of 26.22 ± 33.00 IU/m L. Serum HBV DNA level remained undetectable(< 100 IU/m L) in all treated patients during the study. HBs Ag level of the control group decreased from 25.72 ± 25.58 IU/m L at baseline to 17.11 ± 21.62 IU/m L at week 96(P = 0.108). In the control group, no patient experienced HBs Ag loss/seroconversion, and two(5.0%) developed HBV reactivation.CONCLUSION: IFN treatment results in HBs Ag loss and seroconversion in a considerable proportion of inactive HBs Ag carriers with low HBs Ag concentrations. | Ming-Hui Li Yao Xie Lu Zhang Yao Lu Ge Shen Shu-Ling Wu Min Chang Cai-Qin Mu Lei-Ping Hu Wen-Hao Hua Shu-Jing Song Shu-Feng Zhang Jun Cheng Dao-Zhen Xu | 2016 | World Journal of Hepatology2016，8，15： | 15 |
| 5 | Preliminary report on methane emissions from the Three Gorges Reservoir in the summer drainage period显示文摘Recently reported summertime methane (CH4) emissions (6.7 ± 13.3 mg CH4/(m2·hr)) from newly created marshes in the drawdown area of the Three Gorges Reservoir (TGR), China have triggered broad concern in academic circles and among the public. The CH4 emissions from TGR water surfaces and drawdown areas were monitored from 3rd June to 16th October 2010 with floating and static chambers and gas chromatography. The average CH4 emission flux from permanently flooded areas in Zigui, Wushan and Yunyang Counties was (0.33 ± 0.09) mg CH4/(m2·hr). In half of these hottest months of the year, the wilderness, cropland and deforested drawdown sites were aerobic and located above water level, and the CH4 emissions were very small, ranging from a sink at 0.12 mg CH4/(m2·hr) to a source at 0.08 mg CH4/(m2·hr) except for one mud-covered site after flood. Mean CH4 emission in flooded drawdown sites was 0.34 mg CH4/(m2·hr). The emissions from the rice paddy sites in the drawdown area were averaged at (4.86 ± 2.31) mg CH4/(m2·hr). Excepting the rice-paddy sites, these results show much lower emission levels than previously reported. Our results indicated considerable spatial and temporal variation in CH4 emissions from the TGR. Human activities and occasional events, such as flood, may also affect emission levels. Long-term CH4 measurements and modeling in a large region are necessary to accurately estimate greenhouse gas emissions from the TGR. | Fei Lu Le Yang Xiaoke Wang Xiaonan Duan Yujing Mu Wenzhi Song Feixiang Zheng Junfeng Niu Lei Tong Hua Zheng Yongjuan Zhou Jiangxiao Qiu Zhiyun Ouyang | 2011 | Journal of Environmental Sciences2011，23，12： | 13 |
| 6 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 7 | TiC-Fe coatings prepared by flame spray synthesis process显示文摘A new process, flame spray synthesis (FSS), has been developed for producing ceramic containing composite coatings. By combining self propagation high temperature synthesis (SHS) and flame spraying, the cermet based material was synthesized and deposited simultaneously. TiC Fe coatings were deposited from commercial ferrotitanium, iron and graphite powders by the flame spraying synthesis process. Microstructure analyses revealed that TiC was synthesized during spraying, and that submicron and round TiC particles were dispersed within an iron matrix. Flame spray synthesized coatings were composed of alternate soft and hard layers, whose hardness were 3.0~6.0 GPa and 11~13 GPa, respectively. | LIU Chang song(刘长松) HUANG Ji hua(黄继华) ZHAO Yong(赵 勇) LIU Mu(柳 牧) YIN Sheng(殷 声) | 2000 | 中国有色金属学会会刊:英文版2000，10，3： | 10 |
| 8 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 9 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 10 | High levels of circulating GM-CSF^(+) CD4^(+) T cells are predictive of poor outcomes in sepsis patients: a prospective cohort study显示文摘Granulocyte colony-stimulating factor(GM-CSF),produced by CD4^(+)T cells,has recently been implicated in the pathogenesis of inflammatory diseases,such as multiple sclerosis and juvenile arthritis.However,the role of GM-CSF-producing CD4^(+)T cells in sepsis remains unknown.This study reports peripheral changes in GM-CSF-producing CD4^(+)T cells in septic patients and the possible underlying mechanism by which GM-CSF influences the outcome of sepsis.Forty-three septic patients,20 SIRS patients,and 20 healthy controls were enrolled in this study and followed for 28 days to assess mortality.We measured the peripheral frequency of GM-CSF^(+)CD4^(+)T cells and recorded their associated relationship with disease progression.Our data demonstrated that peripheral GM-CSF-producing CD4^(+)T cells were significantly higher in septic patients than in both SIRS patients and healthy controls.These cells exhibit a memory phenotype and impaired IFN-γ-secreting capacity in sepsis patients.Using a receiver operating curve analysis with 8.01%as a cut-off point,the percentage of GM-CSF^(+)CD4^(+)T cells could predict the outcome of septic patients.Combined with the increase in GM-CSF-producing CD4^(+)T cells,inflammatory cytokines IL-1βand IL-6 were also upregulated.Using an in vitro neutrophil model,we found that GM-CSF inhibited C3aR expression,while inducing IL-8 production.Furthermore,this effect was transferrable in plasma from sepsis patients and was attenuated by inhibition of GM-CSF using an anti-GM-CSF antibody.These results indicate that GM-CSF-producing CD4^(+)T cells may serve as a marker of sepsis severity.Thus,targeting GM-CSF overproduction may benefit sepsis patients. | Huihuang Huang Siyu Wang Tianjun Jiang Rong Fan Zheng Zhang Jinsong Mu Ke Li Yonggang Wang Lei Jin Fang Lin Jie Xia Lijian Sun Biao Xu Chengcheng Ji Jing Chen Juan Chang Bo Tu Bing Song Chao Zhang Fu-Sheng Wang Ruonan Xu | 2019 | Cellular & Molecular Immunology2019，16，6： | 6 |
| 11 | Face Liveness Detection Based on the Improved CNN with Context and Texture Information显示文摘Face liveness detection,as a key module of real face recognition systems,is to distinguish a fake face from a real one.In this paper,we propose an improved Convolutional neural network(CNN)architecture with two bypass connections to simultaneously utilize low-level detailed information and high-level semantic information.Considering the importance of the texture information for describing face images,texture features are also adopted under the conventional recognition framework of Support vector machine(SVM).The improved CNN and the texture feature based SVM are fused.Context information which is usually neglected by existing methods is well utilized in this paper.Two widely used datasets are used to test the proposed method.Extensive experiments show that our method outperforms the state-of-the-art methods. | GAO Chenqiang LI Xindou ZHOU Fengshun MU Song | 2019 | Chinese Journal of Electronics2019，28，6： | 5 |
| 12 | Analyzing the differences of brackish-water in the Badain Lake by geophysical exploration method显示文摘BadainJ aran Desert of Inner Mongolia is arid and rainless all the year around,with much more evaporation than rainfall.But the special groundwater recharge mechanism contributes to the generation of several lakes of different sizes that have never not dried up for years,among which there are many freshwater lakes.As the research object in this paper,East Badain Lake and West Badain Lake in the southeast of the desert,which are less than 50m away from each other,show the considerable difference in mineralization.In fact,one is a freshwater lake,but the other is a brackish-water lake.Considering the underground aquifer structure of BadainJ aran Desert and the special formation structure the particularity of the stratigraphic structure around Badain Lake,the author uses AMT(audio magneto telluric)method and ultra-high density resistivity method to analyze the difference in mineralization of East Badain Lake and West Badain Lake from the perspective of geophysical prospecting methods. | SONG Hong-wei MU Hai-dong XIA Fan | 2018 | Journal of Groundwater Science and Engineering2018，6，3： | 4 |
| 13 | Active sites in CO2 hydrogenation over confined VOx-Rh catalysts显示文摘Metal oxide-promoted Rh-based catalysts have been widely used for CO2 hydrogenation,especially for the ethanol synthesis.However,this reaction usually suffers low CO2 conversion and alcohols selectivity due to the formation of byproducts methane and CO.This paper describes an efficient vanadium oxide promoted Rh-based catalysts confined in mesopore MCM-41.The Rh-0.3VO/MCM-41 catalyst shows superior conversion(〜12%)and ethanol selectivity(〜24%)for CO2 hydrogenation.The promoting effect can be attributed to the synergism of high Rh dispersion by the confinement effect of MCM-41 and the formation of VOr-Rh interface sites.Experimental and theoretical results indicate the formation of til-CO at VOv-Rh interface sites is easily dissociated into*CH X,and then*CH X can be inserted by CO to form CH3,*CO followed by CH3*CO hydrogenation to ethanol. | Guishuo Wang Ran Luo Chengsheng Yang Jimin Song Chuanye Xiong Hao Tian Zhi-Jian Zhao Rentao Mu Jinlong Gong | 2019 | Science China Chemistry2019，62，12： | 4 |
| 14 | Vertical structure and seasonal variation of tidal and residual currents in the northern Huanghai Sea显示文摘Analysis of tidal current and sea level has been made based on the observations from the summer of 2006 to the winter of 2007,respectively.The result indicates that a two-layer structure of residual current exists in summer,with its upper layer going northwestward and the lower layer southeastward.In addition,some strong residuals exist in the neighboring depth of the pycnocline during the current period of astronomical tide.In winter,except some individual layersthe residual currents mostly direct to the northwest,from which we can see the fluctuation of abnormal sea-level and the appearance of associated current because of the changes of the wind field.The analysis of tidal ellipse indicates that the direction of the maximum semidiurnal component is clockwise from summer to winter,with an angle of 16-18.Moreover,in summer the semidiurnal component rotates with depth clockwise while the diurnal component counterclockwise.However,the vertical structure is almost homogeneous in winter. | SONG Jun GUO Junru QIAO Lulu MU Lin YAO Zhigang LIU Yang LI Huan BAO Xianwen SUN Xiaoyan GAO Jia | 2011 | Acta Oceanologica Sinica2011，30，5： | 4 |
| 15 | Novel, Green, Simple and Uncatalyzed Route for High Yield Preparation of Benzaldehyde Glycol Acetal显示文摘A simple approach for the condensation of benzaldehyde with ethylene glycol was adopted without employing any catalyst. The study reveals that factors including temperature, molar ratio of reactants, and the water removal significantly influence the conversion ratio of benzaldehyde. The results indicate that the use of optimal reaction conditions such as temperature and water removing exhibits more pronounced effects on the conversion ratio of benzaldehyde compared with the use of catalysts. In a word, a green and simple method for the condensation of aldehyde and menthandiol has been devised and investigated. | TANG Jia SONG Ji-yuan WANG Ge YANG Mu GUO Wan-chun | 2011 | Chemical Research in Chinese Universities2011，27，5： | 4 |
| 16 | Using intra-operative GeneSearchTM Breast Lymph Node Assay to detect breast cancer metastases in sentinel lymph nodes: results from a single institute in China显示文摘背景哨兵淋巴节点(SLN ) 活体检视为早乳癌病人成为了一个普通过程。GeneSearchTM 胸淋巴节点(十亿) 试金是为检测的即时 RT-PCR 试金比 0.2 公里大的节的转移。中国乳癌临床的学习组(CBCSG )-001a 是一个未来的多中心被进行验证 GeneSearchTM 的临床的试用在 China.Methods 的十亿试金从 90 个连续病人的 SLN 被识别并且把,然后沿着进多重块的短轴的 sectioned。Intra-operatively,奇怪的块被十亿试金测试,偶的被用于冻结的节,当所有块被触摸印记细胞学评估时。Post-operatively,留下的纸巾被组织学的 evaluation.Results 估计 189 SLN 的一个总数被十亿试金测试。敏感,特性,积极预兆的价值,和否定预兆的价值是 88.9%,97.4%,88.9% 并且 97.4% ,分别地为十亿试金, 75.0%,100%,100% 并且 94.4% ,分别地为冻结的节,和 63.9%,100%,100% 并且分别地, 92.2% 为触觉印细胞学。十亿试金的敏感比触觉的高印记细胞学(P=0.01 ) 和冻结的节(P=0.13 ) 。当估计节点与时微转移,十亿试金比冻结的节(P=0.023 ) 和触摸印记细胞学(P=0.005 ).Conclusion 有重要更高的敏感十亿试金是的 GeneSearchTM 为胸 SLN 和它的精确、快速的 intra 起作用的试金一般来说对申请合适诊所。 | SUN Xiao LIU Juan-juan WANG Yong-sheng SONG Xian-rang ZHONG Wei-xia ZHOU Chang-chun MU Dian-bin ZUO Wen-shu YU Zhi-yong ZHOU Zheng-bo | 2011 | Chinese Medical Journal2011，，7： | 4 |
| 17 | siRNA targeting stathmin inhibits invasion and enhances chemotherapy sensitivity of stem cells derived from glioma cell lines显示文摘Glioma 高度是大多数之一 angiogenic 肿瘤,和 glioma 干细胞(GSC ) 为到化疗和放射疗法的抵抗负责,以及在操作以后的复发。Stathmin 为有丝分裂是实质的并且在导出 glioma 的 endothelial 房间的增长和移植起一个重要作用。然而,在 stathmin 和 GSC 之间的关系不完全地被理解。这里,我们从 glioma 房间线 U87MG 和 U251 孤立 GSC,然后使用了为 silencing 指向 stathmin 的 siRNA。我们证明 stathmin 的 silencing 压制了增长,增加了 apoptosis 率,并且逮捕了在在 GSC 的 G2/M 阶段的房间周期。在 GSC 的 stathmin 的 Silencing 也导致了禁止了迁居 / 侵略以及 vasculogenic 的能力模仿。到 temozolomide 的 GSC 的危险性被 stathmin silencing 也提高。我们的调查结果为 glioma 处理在 GSC 作为一个潜在的目标建议 stathmin。 | Yuwen Song Luyan Mu Xuezhe Han Xiaoqian Liu Songbin Fu | 2014 | Acta Biochimica et Biophysica Sinica2014，46，12： | 4 |
| 18 | Catalytic Graphitization of Phenolic Resin显示文摘The catalytic graphitization of thermal plastic phenolic-formaldehyde resin with the aid of ferric nitrate(FN) was studied in detail.The morphologies and structural features of the products including onion-like carbon nanoparticles and bamboo-shaped carbon nanotubes were investigated by transmission electron microscopy(TEM),high-resolution transmission electron microscopy(HRTEM),X-ray diffraction and Raman spectroscopy measurements.It was found that with the changes of loading content of FN and residence time at 1000 ℃,the products exhibited various morphologies.The TEM images showed that bamboo-shaped carbon nanotube consisted of tens of bamboo sticks and onion-like carbon nanoparticle was made up of quasi-spherically concentrically closed carbon nanocages. | Mu Zhao Huaihe Song | 2011 | Journal of Materials Science & Technology2011，27，3： | 4 |
| 19 | Substituent Influence of Yttria by Gadolinia on the Tetragonal Phase Stability for Y_2O_3-Ta_2O_5-ZrO_2 Ceramics at 1300℃显示文摘The influences of equimolar substitution of yttria by gadolinia on the phase constituent and stability for Y_2O_3—Ta_2O_5—ZrO_2 ceramics have been investigated.The ceramics with the Gd content lower than 8 nnol%exhibit pure tetragonal phase as well as high tetragonal phase stability.However,the high Gd containing ceramics consist of t-ZrO_2,m-ZrO_2 and monoclinic GdTaO_4 and show complicated phase evolution behaviors.The fractions of monoclinic ZrO_2 and GdTaO_4 increase with increasing Gd content,indicating that the excessive substitution of Gd for Y results in a reduction in the tetragonal phase stability.In addition,the lower Gd containing ceramics show an almost invariable tetragonality,while the higher Gd containing ceramics reveal a composition-dependent tetragonality.Accordingly,an association of the tetragonal phase stability and tetragonality with the Gd concentration is established,which provides us a clue to understand the phase stability of these ceramics. | Xiaoqing Niu Min Xie Fen Zhou Rende Mu Xiwen Song Shengli An | 2014 | Journal of Materials Science & Technology2014，30，4： | 3 |
| 20 | Compression characteristics of saturated re-compacted glacial tills in Tianmo Gully of Tibet, China显示文摘Glacial tills are highly compressible soils composed of loosely cemented sandy silt particles.Their role,for instance,as initial filler materials in geo-technical projects along temperate glacier regions warrant a systematic evaluation of their compressive characteristics.As such,we carry out a series of onedimensional compression tests on re-compacted glacial till samples obtained from Tianmo Gully,Tibet,with the aims of evaluating their compressive behavior under controlled initial stress conditions.The yield stress was determined from the void ratio versus consolidation pressure(e-log)planes.Its compression and swelling behaviors were observed during the primary and secondary compressions of the consolidation tests.From the compression curves,a correlation can be found between the consolidation stress and the void index.In addition,we find that the compression curves of glacial tills collapse into a single curve when normalized by the compression index.The experimental results in this study provide a basic understanding of the compression characteristics of the glacial tills in Tibet,China. | CHEN Lei-lei ZHOU Gordon G.D MU Qing-yi CUI Kahlil Fredrick SONG Dong-ri | 2019 | Journal of Mountain Science2019，16，7： | 3 |
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