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| 1 | Quaternary glacier development and the relationship between the climate change and tectonic uplift in the Helan Mountain显示文摘孤立拉长 Helan 山脉山岳的 NE-SW,分开从 Tenggeli 沙漠的 Ordos 高原的适度的草地,是在西方中国学习冰河发展的一个关键位置以及气候的联合条件随着变化构造高举。冰川的地形和存款包括冰斗,山峰,刀口山脉,侧面的冰碛,和终端冰碛在 Helan 山的中间的部分在 2800 m a.s.l 上面散布。这分布显示这曾经是 glaciated 在期间晚第四级。形态学特征证明形成事件的风景的一个清楚的序列发生在整个 Helan 山。实验室光学地刺激了光(OSL ) 和标明日期的加速器团 spectrometry 放射性碳(AMS 14C ) 结果显示冰川的进展的迟了的历史。在 Helan 山的中间的部分的迟了的更新世冰河进展了接近他们的位置至少四次,并且冰川的序列能作为最后一个冰川的周期的中间的阶段被分配(MIS3b, 43.2 ????????? ′ ? 錸? 錸?@ | ZHANG Wei HE MingYue LI YongHua CUI ZhiJiu WANG ZhiLin YU Yang | 2012 | Chinese Science Bulletin2012，57，34： | 14 |
| 2 | Vertical dynamic and thermodynamic characteristics of urban lower boundary layer and its relationship with aerosol concentration over Beijing显示文摘By utilizing observational data from a 325 m tower of the Institute of Atmospheric Physics (IAP), Chinese Academy of Sciences (CAS) on March 19-29, 2001 and August 11-25, 2003, a comprehensive study was conducted on the vertical dynamical and thermodynamic characteristics of the urban lower boundary layer (ULBL) and its relationship with aerosol concentration over Beijing. Firstly, a comparative analysis was made on the gradient data (wind, temperature and humidity), ultrasonic data (atmospheric turbulences) and air-quality observations at different tower heights (47, 120 and 280 m). Secondly, a diagnosis was made to reveal the major features of normalized variances of velocity and temperature, turbulence kinetic energy as well as their relationship with aerosol concentrations. Furthermore, the characteristics of the ULBL vertical structure and the TSP concentration/distribution variations during a sand/dust weather process were also analyzed. The outcome of the study showed that under unstable stratification, the normalized variances of velocity (σu/u*, σv/u*, σw/u*) and temperature (σT/T*) at 47 and 120 m heights fit the Monin-Obukhov similarity (MOS) framework and the fitting formulas were given out accordingly. According to the stratification parameter (z′/L), the stable ULBL could be divided into 2 zones. With z′/L<0.1, it was a weakly stable zone and MOS framework was applicable. The other was a highly stable zone with z′/L>0.1 and the normalized velocity variances tended to increase along with higher stability, but it remained constant for normalized temperature variances. At daytime, the near-surface layer includes two heights of 47 and 120 m, while 280 m has been above it. The ULBL analysis in conjunction with a sand/dust weather process in Beijing in March 2001 indicated that the maximum concentration of Total Suspended Particulates (TSP) at 320 m reached 913.3 μg/m3 and the particles were transported from the upper to lower ULBL, which was apparently related to the development process of a low-level jet and its concomitant strong sinking motion. | ZHOU Mingyu, YAO Wenqing, XU Xiangde & YU Haiqing State Key Laboratory on Severe Weather, Chinese Academy of Meteorological Sciences, Beijing 100081, China National Marine Environment Forecasting Center, Beijing 100081, China National Meteorological Center, Beijing 100081, China | 2005 | Science China Earth Sciences2005，48，z2： | 11 |
| 3 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 4 | Inflammation and tumor progression:signaling pathways and targeted intervention显示文摘Cancer development and its response to therapy are regulated by inflammation,which either promotes or suppresses tumor progression,potentially displaying opposing effects on therapeutic outcomes.Chronic inflammation facilitates tumor progression and treatment resistance,whereas induction of acute inflammatory reactions often stimulates the maturation of dendritic cells(DCs)and antigen presentation,leading to anti-tumor immune responses.In addition,multiple signaling pathways,such as nuclear factor kappa B(NF-kB),Janus kinase/signal transducers and activators of transcription(JAK-STAT),toll-like receptor(TLR)pathways,cGAS/STING,and mitogen-activated protein kinase(MAPK);inflammatory factors,including cytokines(e.g.,interleukin(IL),interferon(IFN),and tumor necrosis factor(TNF)-a),chemokines(e.g.,C-C motif chemokine ligands(CCLs)and C-X-C motif chemokine ligands(CXCLs)),growth factors(e.g.,vascular endothelial growth factor(VEGF),transforming growth factor(TGF)-P),and inflammasome;as well as inflammatory metabolites including prostaglandins,leukotrienes,thromboxane,and specialized proresolving mediators(SPM),have been identified as pivotal regulators of the initiation and resolution of inflammation.Nowadays,local irradiation,recombinant cytokines,neutralizing antibodies,small-molecule inhibitors,DC vaccines,oncolytic viruses,TLR agonists,and SPM have been developed to specifically modulate inflammation in cancer therapy,with some of these factors already undergoing clinical trials.Herein,we discuss the initiation and resolution of inflammation,the crosstalk between tumor development and inflammatory processes.We also highlight potential targets for harnessing inflammation in the treatment of cancer. | Huakan Zhao Lei Wu Guifang Yan Yu Chen Mingyue Zhou Yongzhong Wu Yongsheng Li | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 11 |
| 5 | Ecological vulnerability analysis of Beidagang National Park,China显示文摘Ecological vulnerability analysis (EVA) is vital for ecological protection,restoration,and management of wetland-type national parks.In this study,we assessed the ecological vulnerability of Beidagang National Park based upon remote sensing (RS) and geographic information system (GIS) technologies.To quantify the ecological vulnerability,10 indices were collected by the 'exposuresensitivity- adaptive capacity' model and spatial principal component analysis (SPCA) was then applied to calculate the ecological vulnerability degree (EVD).Based on the numerical values,EVD of the study area was classified into five levels: moderate,light,medium,strong,and extreme.Results showed that the average EVD value was approximately 0.39,indicating overall good ecological vulnerability in Beidagang National Park.To be specific,80.42% of the whole area was assigned to a moderate level of EVD with the highest being the tourism developed areas and the lowest being the reservoirs and offshore areas.Ecological vulnerability of the region was determined to be affected by the natural environment and anthropogenic disturbance jointly.The primary factors included tourism disturbance,traffic interference,exotic species invasion,land use/land cover,and soil salinization.We expected to provide some insights of the sustainable development of Beidagang National Park and would like to extend the results to other wetland-type national parks in the future. | Xue YU Yue LI Min XI Fanlong KONG Mingyue PANG Zhengda YU | 2019 | Frontiers of Earth Science2019，13，2： | 10 |
| 6 | Diversity of arbuscular mycorrhizal fungal spore communities and its relations to plants under increased temperature and precipitation in a natural grassland显示文摘Arbuscular mycorrhizal fungi(AMF)form mutualisms with most plant species,and therefore,understanding how AMF communities will respond to climate change is essential for predictions of changes in plant communities.To evaluate the impact of global climate change on AMFs and plant-AMF interactions in a natural grassland in Inner Mongolia,both artificial warming and watering treatments were assigned to experimental plots.Our results indicate that(1)warming and precipitation significantly affected the relative spore abundance of abundant sporulating AMF species;(2)the relative abundance of weak sporulating AMF species and AMF diversity decreased under experimental warming;(3)evidence was found that the composition of the AMF community in a given year might be correlated with plant community composition in the following year;and(4)grasses and forbs showing different preferences to Claroideoglomus etunicatum or Ambispora gerdemannii dominated plots.Our results imply that climate change appears to induce changes in AMF assemblages with knock-on effects on grassland plant communities.AMF communities may play a much more important role than we have thought in the responses of ecosystem to global climate changes. | SUN XiuFeng SU YuanYing ZHANG Ying WU MingYu ZHANG Zhe PEI KeQuan SUN LiFu WAN ShiQiang LIANG Yu | 2013 | Chinese Science Bulletin2013，58，33： | 6 |
| 7 | White-light emitting single-phase phosphor La_3Si_6N_(11):Dy^(3+),Tb^(3+):Color tunable emission, thermal stability and energy transfer process显示文摘A novel white-light emitting single-phase phosphor La_3 Si_6 N_(11):Dy^(3+),exhibiting two emission peaks centering at 475 and 575 nm, was prepared via conventional solid-state reactions. The structure and morphology of La_3 Si_6 N_(11):Dy^(3+)/Tb^(3+) were investigated by X-ray diffraction(XRD) and scanning electron microscopy(SEM). The emission colors can be tuned from white to yellow-green through increasing the Tb^(3+) concentration in La_3 Si_6 N_(11):Dy^(3+),Tb^(3+), The mechanism of energy transfer(ET) from Dy^(3+) to Tb^(3+) is confirmed according to the excitation,emission spectra and decay lifetimes curve. The temperaturedependent luminescence measurements of La_(2.83)Si_6 N_(11):0.1 Dy^(3+),0.07 Tb^(3+) were also performed, and a good thermal stability is shown, suggesting superior properties for the application as white lightemitting diodes(w-LEDs) phosphor. | Yuanhong Liu Yuan Xue Ronghui Liu Mingyue Chen Guantong Chen Chunpei Yan Xia Zhang Yu'nan Zhou Wei Gao Xiaole Ma | 2019 | Journal of Rare Earths2019，37，4： | 5 |
| 8 | Tunable Co/ZnO/C@MWCNTs based on carbon nanotube-coated MOF with excellent microwave absorption properties显示文摘The development of global information technology makes human life intelligent,and the large-scale use of various electronic devices increases the electromagnetic radiation in the surrounding environment.This has created a requirement for the development of high-performance electromagnetic wave absorbers to eliminate electromagnetic pollution.However,the preparation of electromagnetic wave absorbers with excellent electromagnetic loss capability remains a great challenge.Here,we present a method to prepare Co/ZnO/C@MWCNTs(CZC@M)composites by pyrolysis of ZnCo-MOF@MWCNTs(MOF@M).Specifically,MWCNTs are uniformly distributed on the CZC surface to form multiple heterogeneous interfaces,which will lead to an increase in polarizability.In addition,changing the amounts of MWCNTs in the composite can modulate its dielectric constant and impedance matching properties.Impressively,at only 10%sample content,the minimum reflection loss of-41.75 d B and the maximum effective absorption bandwidth of 4.72 GHz are obtained at thicknesses of 2.4 mm and 2.2 mm,respectively.Overall,the results reported in this work provide a new design strategy for the synthesis of high-performance electromagnetic wave absorbers with potential applications in the elimination of electromagnetic pollution. | Zirui Jia Mingyue Kong Bowen Yu Yingzhuo Ma Jiaying Pan Guanglei Wu | 2022 | Journal of Materials Science & Technology2022，，32： | 5 |
| 9 | Distribution, sources and burial fl ux of sedimentary organic matter in the East China Sea显示文摘Distribution of total organic carbon(TOC),total nitrogen(TN),stable isotope ratio of organic carbon and nitrogen(δ13 C andδ15 N)in 31 surface sediments were examined to quantitatively discriminate the source and burial of sedimentary organic matter(SOM)in the East China Sea(ECS).Results show that high content of TOC and TN occurred in the southern inner shelf and the northeast area due to the transport of organic matter(OM)from the Changjiang(Yangtze)River southwards by the Zhejiang Fujian Coastal Current(ZFCC)and the delivery from the old Huanghe(Yellow)River estuary by the Subei Coastal Current(SbCC),respectively.The signifi cant relationship of TOC to clay provided evidence that the fi ne-grained sediment was the primary carrier for SOM from the inner shelf to open sea.The TN varied proportionally to the TOC with the neglected intercept,suggesting that most of nitrogen measured was related to the SOM and the infl uence of the sorption of inorganic nitrogen was insignifi cant.The seaward enrichment ofδ13 C and seaward depletion of C/N andδ15 N illustrated the decrease of terrestrial OM(TOM)and the increase of marine OM(MOM).The close of average C/N ratio to the Redfi eld ratio indicated the minor role of terrestrial plant debris in the SOM.Distribution of bulk OM properties was ascribed to the terrestrial and marine input by the shelf circulation and phytoplankton with the contributions of 76.1%MOM and 23.9%TOM to SOM,respectively.The burial fl ux of OC ranged within 0.34–7.56 mg/(cm 2∙a)(averaged 2.80 mg/(cm 2∙a))and enriched along the shore and in the fi ne-grained area,manifesting the signifi cant input of the land-based sources and the eff ect of shelf mud depositional process on the fate of SOM.The sharp seaward decrease of burial fl uxes of terrestrial and marine OC gave evidences that the majority of organic carbon were settled in the inner shelf with the small fraction of them further transported eastwards. | WU Xiaodan WU Bin JIANG Mingyu CHANG Fengming NAN Qingyun YU Xinke Saren Gaowa | 2020 | Journal of Oceanology and Limnology2020，38，5： | 5 |
| 10 | Arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells:comparison of vasorelaxant effects of verapamil and phentolamine显示文摘Mitochondria are morphologically dynamic organelles which undergo fission and fusion processes. Our previous study found that arterial constriction was always accompanied by increased mitochondrial fission in smooth muscle cells, whereas inhibition of mitochondrial fission in smooth muscle cells was associated with arterial relaxation. Here, we used the typical vasorelaxants, verapamil and phentolamine, to further confirm the coupling between arterial constriction and mitochondrial fission in rat aorta. Results showed that phentolamine but not verapamil induced vasorelaxation in phenylephrine(PE)-induced rat thoracic aorta constriction. Verapamil, but not phentolamine, induced vasorelaxation in high K^+(KPSS)-induced rat thoracic aorta constriction. Pre-treatment with phentolamine prevented PEbut not KPSS-induced aorta constriction and pre-treatment with verapamil prevented both PE-and KPSSinduced aorta constriction. Transmission electron microscopy(TEM) results showed that verapamil but not phentolamine inhibited KPSS-induced excessive mitochondrial fission in aortic smooth muscle cells,and verapamil prevented both PE-and KPSS-induced excessive mitochondrial fission in aortic smoothmuscle cells. Verapamil inhibited KPSS-induced excessive mitochondrial fission in cultured vascular smooth muscle cells(A10). These results further demonstrate that arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells. | Jing Jin Xin Shen Yu Tai Shanliang Li Mingyu Liu Changlin Zhen Xiuchen Xuan Xiyue Zhang Nan Hu Xinzi Zhang Deli Dong | 2017 | Acta Pharmaceutica Sinica B2017，7，3： | 5 |
| 11 | Emerging Variants of B.1.617 Lineage Identified Among Returning Chinese Employees Working in India—Chongqing Municipality,China,April 2021显示文摘On April 22 and 23,2021,3 confirmed COVID-19 cases in passengers on an arriving airplane from Nepal were reported by Chongqing Public Health Medical Center.Preliminary epidemiological investigation revealed these 3 patients,males aged 20-30 years,were coworkers of a cellphone company that has a manufacturing base in Noida,India,where they worked with their Indian colleagues since late 2019. | Sheng Ye Yongjun Zhang Xiang Zhao Zhen Yu Yang Song Zhangping Tan Yun Tang Shuang Chen Mingyue Wang Hua Ling | 2021 | China CDC weekly2021，3，19： | 4 |
| 12 | Cold Stress-induced Glucosyltransferase CsUGT78A15 is Involved in the Formation of Eugenol Glucoside in Camellia sinensis显示文摘Eugenol is a natural phenolic compound known for its health-promoting properties and its ability to add a floral scent to tea plants.Plant eugenol glycosides have been identified and shown to make important contributions to fruit floral quality.However,the details of their biosynthesis and metabolism in tea plants are still unknown.Here,eugenol glucoside was unambiguously identified as a native metabolite in the tea plant,and its biosynthesis was shown to be induced by low temperature treatment.Through the analysis of UGTs induced by low temperature,the glycosyltransferase CsUGT78A15 was identified in tea,and its encoded protein was shown to catalyze the glucosylation of eugenol.Vmax/Km ratios showed that eugenol was the most suitable substrate for CsUGT78A15.Sugar donor preference analysis showed that CsUGT78A15 had a higher selectivity for glucose,followed by galactose and glucuronic acid.The expression of CsUGT78A15was correlatedwith the accumulation of eugenol glucoside in different tissues and genotypes of tea.Down-regulation of CsUGT78A15 led to a decreased eugenol glucoside content under cold stress,indicating that CsUGT78A15 plays an important role in the biosynthesis of eugenol glucoside under cold stress.The identification of eugenol glucoside in the tea plant and the discovery of a cold stress-induced eugenol glucosyltransferase in tea provide the foundation for the improvement of tea flavor under cold stress and the biotechnological production of eugenol glucoside. | Mingyue Zhao Binbin Cai Jieyang Jin Na Zhang Tingting Jing Jingming Wang Yuting Pan Zixiang Zhou Yifan Zhao Yingying Feng Feng Yu Mengting Zhang Yating Li Zhonghua Liu Chuankui Song | 2020 | Horticultural Plant Journal2020，6，6： | 4 |
| 13 | rAAV/ABAD-DP-6His attenuates oxidative stressinduced injury of PC12 cells显示文摘Our previous studies have revealed that amyloid β(Aβ)-binding alcohol dehydrogenase(ABAD) decoy peptide antagonizes Aβ42-induced neurotoxicity. However, whether it improves oxidative stress injury remains unclear. In this study, a recombinant adenovirus constitutively secreting and expressing Aβ-ABAD decoy peptide(rAAV/ABAD-DP-6His) was successfully constructed. Our results showed that rAAV/ABAD-DP-6His increased superoxide dismutase activity in hydrogen peroxide-induced oxidative stress-mediated injury of PC12 cells. Moreover, rAAV/ABADDP-6His decreased malondialdehyde content, intracellular Ca2+ concentration, and the level of reactive oxygen species. rAAV/ABAD-DP-6His maintained the stability of the mitochondrial membrane potential. In addition, the ATP level remained constant, and apoptosis was reduced. Overall, the results indicate that rAAV/ABAD-DP-6His generates the fusion peptide, Aβ-ABAD decoy peptide, which effectively protects PC12 cells from oxidative stress injury induced by hydrogen peroxide, thus exerting neuroprotective effects. | Mingyue Jia Mingyu Wang Yi Yang Yixin Chen Dujuan Liu Xu Wang Lei Song Jiang Wu Yu Yang | 2014 | Neural Regeneration Research2014，9，5： | 3 |
| 14 | Crystal structure of the African swine fever virus structural protein p35 reveals its role for core shell assembly显示文摘Dear Editor,The African swine fever(ASF)is a highly contagious hemorrhagic and lethal disease in domestic pigs.The ASF outbreaks of in many Asia countries,including China,Vietnam,Mongolia,and South Korea,have posed a huge threat to the pig indusry.In the attempt to stop ASF from spreading further in China's Mainland,more than 10 million pigs have been culled since August 2018.The causative agent for ASF is a DNA virus,African swine fever virus(ASFV).Although this deadly disease has been reported in Kenya nearly one hundred years ago,there has been no vaccine for protection from ASFV infection or effective treatments to cure ASF until now. | Guobang Li Dan Fu Guangshun Zhang Dongming Zhao Mingyu Li Xue Geng Dongdong Sun Yuhui Wang Cheng Chen Peng Jiao Lin Cao Yu Guo Zihe Rao | 2020 | Protein & Cell2020，11，8： | 3 |
| 15 | Structure of African swine fever virus p15 reveals its dual role for membrane-association and DNA binding显示文摘Dear Editor, African swine fever (ASF) is a highly contagious disease of domestic pigs caused by African swine fever virus (ASFV),with mortality rates approaching 90%-100%.The first ASF case was described in 1921 in Kenya.Over the past decades, ASF has spread from Sub-Saharan Africa to Europe and Asia, and pose a huge threat to global food safety.Since the first ASF case reported in August 2018, more than 10 million pigs had been culled in China at an enormous economic loss.The risk of ASFV mutating to infect humans is extremely low.However, ASF not only threatens food security but also severely strikes the world economy in many fields, such as the global supply of the blood thinner heparin,most of which is produced from pigs.Hence, ASF is a strictly monitored infectious animal disease by OIE (World Organization for Animal Health), unfortunately, there is no approved drug or vaccine against this lethal viral disease. | Dan Fu Dongming Zhao Wei Zhang Guangshun Zhang Mingyu Li Zheng Zhang Yuhui Wang Dongdong Sun Peng Jiao Cheng Chen Yu Guo Zihe Rao | 2020 | Protein & Cell2020，11，8： | 3 |
| 16 | Nonlinear vibration response characteristics of a dual-rotor-bearing system with squeeze film damper显示文摘Rolling bearing and Squeeze Film Damper(SFD)are used in rotor support structures,and most researches on the nonlinear rotor-bearing system are focused on the simple rotor-bearing systems.This work emphasizes the comparative analysis of the influence of SFD on the nonlinear dynamic behavior of the dual-rotor system supported by rolling bearings.Firstly,a reduced dynamic model is established by combining the Finite Element(FE)method and the freeinterface method of component mode synthesis.The proposed model is verified by comparing the natural characteristics obtained from an FE model with those from the experiment.Then,the steady-state vibration responses of the system with or without SFD are solved by the numerical integration method.The influences of the ball bearing clearance,unbalance,centralizing spring stiffness and oil film clearance of SFD on the nonlinear steady-state vibration responses of the dual-rotor system are analyzed.Results show that SFD can effectively suppress the amplitude jump of the dual rotor system sustaining two rotors unbalance excitations.As the ball bearing clearance or unbalance increases,the amplitude jump phenomenon becomes more obvious,the resonance hysteresis phenomenon strengthens or weakens,the resonant peaks shift to the left or the right,respectively.SFD with unreasonable parameters will aggravate the system vibration,the smaller the oil film clearance,the better the damping performance of the SFD,the larger the centralizing spring stiffness is,the larger resonance amplitudes are. | Xinxing MA Hui MA Haiqin QIN Xumin GUO Chenguang ZHAO Mingyue YU | 2021 | Chinese Journal of Aeronautics2021，34，10： | 3 |
| 17 | Wuzi Yanzong prescription(五子衍宗丸)from Traditional Chinese Medicine for male infertility:a narrative review显示文摘Wuzi Yanzong prescription(WYP),as a classical prescription for male infertility with kidney essence deficiency,is composed of Gouqizi(Fructus Lycii),Tusizi(Semen Cuscutae),Wuweizi(Fructus Schisandrae Chinensis),Fupenzi(Fructus Rubi Chingii)and Cheqianzi(Semen Plantaginis).It has been used for hundreds of years in the treatment of male infertility,known as“the first prescription of ancient and modern seeds”,with convincing clinical evidence.At present,more than 100 chemical compounds have been isolated from WYP,including polysaccharide,fatty acids,flavonoids,phenylpropanoids,organic acids,alkaloids,terpenoids,etc.Pharmacological and clinical studies show that WYP has an obvious effect on reproductive system diseases,especially male infertility,which has a very wide application prospect.It also has effects on the nervous system,inhibiting liver injury,lowering blood sugar and blood lipid,anti-aging,improving immunity,resisting hypoxia and fatigue effects.This study reviewed the chemical constituents,quality control,pharmacology,and clinical application of WYP.There is no doubt about the clinical value of WYP,but its quality control system is not perfect,pharmacological mechanism is not fully explained,and clinical applications need to be reevaluated.Therefore,the follow-up researches should proceed from the theory of Traditional Chinese Medicine(TCM)and clinical applications,further explain the theoretical connotation,reveal the mechanism of action,and provide the basis for the secondary development of classic famous prescriptions.In addition,WYP is mostly used in combination with western medicines besides being used alone.Whether it can improve the efficacy and reduce side effects will also be a meaningful research direction in the future. | CHEN Zhimin AO Mingyue LIAO Yujiao YU Lingying YANG Zhuo HU Lin LI Wenbing HU Changjiang GAO Yongxiang | 2023 | Journal of Traditional Chinese Medicine2023，43，2： | 3 |
| 18 | Applying high-performance computing in drug discovery and molecular simulation显示文摘In recent decades, high-performance computing(HPC) technologies and supercomputers in China have significantly advanced, resulting in remarkable achievements. Computational drug discovery and design,which is based on HPC and combines pharmaceutical chemistry and computational biology, has become a critical approach in drug research and development and is financially supported by the Chinese government. This approach has yielded a series of new algorithms in drug design, as well as new software and databases. This review mainly focuses on the application of HPC to the fields of drug discovery and molecular simulation at the Chinese Academy of Sciences, including virtual drug screening, molecular dynamics simulation, and protein folding. In addition, the potential future application of HPC in precision medicine is briefly discussed. | Tingting Liu Dong Lu Hao Zhang Mingyue Zheng Huaiyu Yang Yechun Xu Cheng Luo Weiliang Zhu Kunqian Yu Hualiang Jiang | 2016 | National Science Review2016，3，1： | 2 |
| 19 | The novel amyloid-beta peptide aptamer inhibits intracellular amyloid-beta peptide toxicity显示文摘Amyloid β peptide binding alcohol dehydrogenase (ABAD) decoy peptide (DP) can competitively antagonize binding of amyloid β peptide to ABAD and inhibit the cytotoxic effects of amyloid β peptide. Based on peptide aptamers, the present study inserted ABAD-DP into the disulfide bond of human thioredoxin (TRX) using molecular cloning technique to construct a fusion gene that can express the TRX1-ABAD-DP-TRX2 aptamer. Moreover, adeno-associated virus was used to allow its stable expression. Immunofluorescent staining revealed the co-expression of the transduced fusion gene TRX1-ABAD-DP-TRX2 and amyloid β peptide in NIH-3T3 cells, indicating that the TRX1-ABAD-DP-TRX2 aptamer can bind amyloid β peptide within cells. In addition, cell morphology and MTT results suggested that TRX1-ABAD-DP-TRX2 attenuated amyloid β peptide-induced SH-SY5Y cell injury and improved cell viability. These findings confirmed the possibility of constructing TRX-based peptide aptamer using ABAD-DP. Moreover, TRX1-ABAD-DP-TRX2 inhibited the cytotoxic effect of amyloid β peptide. | Xu Wang Yi Yang Mingyue Jia Chi Ma Mingyu Wang Lihe Che Yu Yang Jiang Wu | 2013 | Neural Regeneration Research2013，8，1： | 2 |
| 20 | Amelioration of weld-crack resistance of the M951 superalloy by engineering grain boundaries显示文摘Fusion weld is a portable and economical joining and repairing method of metals.However,weld cracks often occur during the fusion weld of Ni-base superalloys,which hinder the applications of fusion weld on this kind of materials.In this work,the effects of microstructures of grain boundaries(GBs)of the prototype M951 superalloy on its weldability were investigated.The precipitated phases,the elemental segregations on GBs,and the morphologies of GBs can be largely altered by regulating the cooling rates of pre-weld heat treatments.With decreasing the cooling rate,chain-like M_(23)X_(6)phase precipitates along the GBs,accompanying segregations of B,and GBs becomes more serrated in morphology.During fusion weld,the engineered GBs in the M951 superalloy with a low cooling rate favor the formation of the continuous liquid films on GBs,which together with the serrated GB morphology significantly prevents the formation of weld cracks.Our findings imply that the weld-crack resistance of the superalloys can be ameliorated by engineering GBs. | Mingyue Wen Yuan Sun Jinjiang Yu Shulin Yang Xingyu Hou Yanhong Yang Xiaofeng Sun Yi Zhou Zhou | 2021 | Journal of Materials Science & Technology2021，，19： | 2 |
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