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| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | Nutritional and medicinal characteristics of Chinese giant salamander (Andrias davidianus) for applications in healthcare industry by artificial cultivation: A review显示文摘Andrias davidianus,i.e.Chinese giant salamander(CGS),is one of the largest and oldest amphibians existing in the world and is also one of the valuable biological resources of China.Wild CGS has been threatened with extinction in the past decades due to over capturing,deterioration of natural environment,the slow breeding and growth of the wild species in nature.However,in the past twenty years,with the breakthrough and progress of artificial breeding technology by artificial insemination,the number of artificially cultivated CGS has increased rapidly.Artificially cultivated CGS can either be released to the CGS living environment to increase the population in nature or legally applied in food and medicinal industry as a feedstock due to the unique nutritional and medicinal values of CGS as recorded historically.In this review,the nutritional components,bioactive components and medicinal activities of the artificially cultivated CGS will be summarized.The mucus,skin,meat and bone of CGS contain many different bioactive substances thereby having various medicinal activities including anti-aging,anti-fatigue,anti-tumor,therapy of burn and anti-infection and other physiological functions.This paper will further discuss the potential applications of the artificially cultivated CGS in healthcare industry and prospects of future technological development. | Dong He Wenming Zhu Wen Zenga Jun Lin Yang Ji Yi Wang Chong Zhang Yuan Lu Daoquan Zhao Nan Su Xin-Hui Xing | 2018 | Food Science and Human Wellness2018，7，1： | 28 |
| 3 | Indoor Allergen Levels and Household Distributions in Nine Cities Across China显示文摘Objective Chinese allergic subjects have high levels of sensitization to house dust mite(HDM) and other indoor allergens. This study quantifies common indoor allergen levels in Chinese households. Methods Dust samples were collected from nine cities. Major allergens Der p 1 and Der f 1 from Dermatophagoides pteronyssinus and D. farinae, and specific antigens of Blomia tropicalis, Tyrophagus putrescentiae, Acarus siro, and cockroach species Blattella germanica and Periplaneta americana were measured by ELISA. Results HDM allergens were found in dust samples from bedding in 95% of the Chinese households. The median levels varied from <0.006 to 9.2 μg/g of dust, depending on the city. The percentages of households having HDM allergen levels associated with the risk of developing allergy sensitization and asthma were 65% and 25%, respectively. Specific antigens of the storage mite and cockroach were only found in samples from the southern and tropical regions of China. Levels of mite allergens were generally higher in samples from bedding compared to samples from the living room, even for storage mites, whereas levels of cockroach antigens were higher in the living room samples. Conclusion HDM allergens are present in bedding dust samples from most Chinese households. Cities in southern and central China have relatively high levels of HDM major allergens compared to cities in northern and western China. Antigens of storage mites and cockroaches are not as common as HDM allergens. | ZHENG Yi Wu LAI Xu Xin ZHAO De Yu ZHANG Chun Qing CHEN Jian Jun ZHANG Luo WEI Qing Yu CHEN Shi LIU En Mei NORBACK Dan GJESING Birgitte ZHONG Nan Shan SPANGFORT D.Michael | 2015 | Biomedical and Environmental Sciences2015，28，10： | 24 |
| 4 | Coastal acidification in summer bottom oxygen-depleted waters in northwestern-northern Bohai Sea from June to August in 2011显示文摘Dissolved oxygen(DO) and pH in the central part of the Bohai Sea were surveyed in late June and late August,2011.During the June cruise,the bottom DO was in the range of 215-290 μmol-O2 kg-1(i.e.85%-115% of the saturation level),and the bottom pH was in the range of 7.82-8.04 on the total-hydrogen-ion scale.In August,however,both the bottom DO and the pH had significantly declined in the northwestern-northern near-shore areas,where the water depth was no more than 35 m.The lowest bottom DO was 100-110 μmol-O2 kg-1(only 44%-47% of the June DO values) in the northern near-shore area,where the bottom pH was 7.64-7.68 on the total-hydrogen-ion scale(0.16-0.20 units lower than the June pH value).The largest decreases in DO and in pH were observed in the northwestern near-shore bottom waters,corresponding to declines of 170 μmol-O2 kg-1(as high as 59% of the June DO value) and 0.29 pH units,respectively.The greatest pH decline of 0.29 pH units meant that the total-hydrogen-ion concentration doubled in the bottom waters from June to August.Based on field measurements of bottom DO/pH combined with a simplified model simulation,we suggest that respiration/remineralization-derived CO2 increased the acidity in the bottom oxygen-depleted waters of northwestern-northern near-shore areas in the Bohai Sea as a result of coastal red tides and/or marine aquaculture.This aquatic chemistry is suggested to be partially responsible for scallop-breeding failures in the northwestern Bohai Sea in summer 2011. | ZHAI WeiDong ZHAO HuaDe ZHENG Nan XU Yi | 2012 | Chinese Science Bulletin2012，57，9： | 22 |
| 5 | Aerodynamic Modeling and Parameter Estimation from QAR Data of an Airplane Approaching a High-altitude Airport显示文摘Aerodynamic modeling and parameter estimation from quick accesses recorder (QAR) data is an important technical way to analyze the effects of highland weather conditions upon aerodynamic characteristics of airplane. It is also an essential content of flight accident analysis. The related techniques are developed in the present paper, including the geometric method for angle of attack and sideslip angle estimation, the extended Kalman filter associated with modified Bryson-Frazier smoother (EKF-MBF) method for aerodynamic coefficient identification, the radial basis function (RBF) neural network method for aerodynamic modeling, and the Delta method for stability/control derivative estimation. As an application example, the QAR data of a civil airplane approaching a high-altitude airport are processed and the aerodynamic coefficient and derivative estimates are obtained. The estimation results are reasonable, which shows that the developed techniques are feasible. The causes for the distribution of aerodynamic derivative estimates are analyzed. Accordingly, several measures to improve estimation accuracy are put forward. | WANG Qing WU Kaiyuan ZHANG Tianjiao KONG Yi'nan QIAN Weiqi | 2012 | Chinese Journal of Aeronautics2012，25，3： | 19 |
| 6 | Fish sauce and gastric cancer:an ecological study in Fujian Province,China显示文摘AIM To explore the relationship betweenconsumption of fish sauce and the risk of gastriccancer in Fujian Province.METHODS An ecological study was carriedout.A total of 11000 subjects from 55 townshipswere randomly selected from 10 counties withinFujian Province.All subjects were localresidents who had been living in Fujian Provincefor more than 20 years,within the age group of45-74 years.Trained interviewers conductedface-to-face interviews with a standardizedquestionnaire,which covered the frequency andamount of food intake,dietary habit,tobaccoand alcohol consumption and history of chronicgastric diseases.Univariate and multivariateanalyses were performed using Epi-info and SASstatistical packages,respectively.RESULTS A significant correlation betweenmonthly consumption of fish sauce and mortalityof gastric cancer was found.Pearson’scoefficient of correlation was statisticallysignificant with r=0.7356 for males,r=0.5246for females(P<0.01).In the multivariateanalysis,consumption of fish sauce still showedan association with the risk of gastric cancer.No significant positive correlation betweenesophagus cancer,liver cancer,colon cancerand consumption of fish sauce were observed.CONCLUSION Long-term intake of fish saucemay be related to high mortality of gastriccancer.Consumption of fish sauce might be oneof important and unique etiologic factors ofgastric cancer in Fujian Province.Furtherstudies are needed to confirm this ecologicalstudy. | Lin Cai Shun Zhang Yu Wei Min Ye Ying Nan Yi | 2000 | World Journal of Gastroenterology2000，6，5： | 18 |
| 7 | Chemical constituents,biological functions and pharmacological effects for comprehensive utilization of Eucommia ulmoides Oliver显示文摘Eucommia ulmoides Oliver is a native plant and valuable tonic Chinese medicine in China with a long history,great economic value and comprehensive development potential.Traditionally,the comprehensive utilization rate of E.ulmoides Oliv.is still very low,only bark has been used as medicine and other parts of Eucommia ulmoides Oliv.cannot be fully utilized,even the leaves have been well utilized in food products in Japan in the past decades.In order to improve the comprehensive utilization efficiency of E.ulmoides Oliv.,in this review,we summarized the varieties and contents of main active compounds,biological functions and pharmacological effects in different parts of E.ulmoides Oliv.The findings suggest that other parts of E.ulmoides Oliv.could replace the bark of E.ulmoides Oliv.to some extent besides of their respective applications.The unique and extensive physiological functions between different parts of E.ulmoides Oliv.indicate that the comprehensive utilization of E.ulmoides Oliv.has a wide space to develop,which is also an effective way to protect E.ulmoides Oliv.resources and improve its the utilization rate. | Yi-Fan Xing Dong He Yi Wang Wen Zeng Chong Zhang Yuan Lu Nan Su Yan-Hua Kong Xin-Hui Xing | 2019 | Food Science and Human Wellness2019，8，2： | 18 |
| 8 | Diet and gastric cancer:a case-control study in Fujian Province,China显示文摘NTRODUCTIONChangleandFuqingcitiesarelocatedinthesoutheasternpartofFujianProvince,Chinawithahighincidenceofgastriccancer.Howev... | YE Wei Min 1, YI Ying Nan 1, LUO Ren Xia 2, ZHOU Tian Shu 3, LIN Ru Tao 1 and CHEN Gui Dong 3 | 1998 | World Journal of Gastroenterology1998，4，6： | 12 |
| 9 | Altered intrinsic functional connectivity of the primary visual cortex in youth patients with comitant exotropia: a resting state fMRI study显示文摘AIM: To evaluate the differences in the functional connectivity(FC) of the primary visual cortex(V1) between the youth comitant exotropia(CE) patients and health subjects using resting functional magnetic resonance imaging(f MRI) data.METHODS: Totally, 32 CEs(25 males and 7 females) and 32 healthy control subjects(HCs)(25 males and 7 females) were enrolled in the study and underwent the MRI scanning. Two-sample t-test was used to examine differences in FC maps between the CE patients and HCs. RESULTS: The CE patients showed significantly less FC between the left brodmann area(BA17) and left lingual gyrus/cerebellum posterior lobe, right middle occipital gyrus, left precentral gyrus/postcentral gyrus and right inferior parietal lobule/postcentral gyrus. Meanwhile, CE patients showed significantly less FC between right BA17 and right middle occipital gyrus(BA19, 37).CONCLUSION: Our findings show that CE involves abnormal FC in primary visual cortex in many regions, which may underlie the pathologic mechanism of impaired fusion and stereoscopic vision in CEs. | Pei-Wen Zhu Xin Huang Lei Ye Nan Jiang Yu-Lin Zhong Qing Yuan Fu-Qing Zhou Yi Shao | 2018 | International Journal of Ophthalmology(English edition)2018，11，4： | 11 |
| 10 | Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KKAy mice显示文摘Refined-JQ(JQ-R) is a mixture of refined extracts from Coptis chinensis(Ranunculaceae),Astragalus membranaceus(Leguminosae) and Lonicera japonica(Caprifoliaceae), the three major herbs of Jin Qi-Jiang Tang tablet, a traditional Chinese medicine(TCM) formula. The mechanisms by which JQ-R regulates glucose metabolism and improves insulin sensitivity were studied in type 2 diabetic KK^(Ay)mice and insulin-resistant L6 myotubes. To investigate the mechanisms by which JQ-R improves insulin sensitivity, a model of insulin-resistant cells induced with palmitic acid(PA) was established in L6 myotubes. Glucose uptake and expression of factors involved in insulin signaling, stress, and inflammatory pathways were detected by immunoblotting. JQ-R showed beneficial effects on glucose homeostasis and insulin resistance in a euglycemic clamp experiment and decreased fasting insulin levels in diabetic KK^(Ay)mice. JQ-R also improved the plasma lipid profiles. JQ-R directly increased the activity of superoxide dismutase(SOD) and decreased malondialdehyde(MDA) as well as inducible nitric oxide synthase(iNOS) levels in insulin-resistant L6 cells, and elevated the insulin-stimulated glucose uptake with upregulated phosphorylation of AKT. The phosphorylation levels of nuclear factor kappa B(NF-κB p65), inhibitor of NF-κB(IκBα), c-Jun N-terminal kinase(JNK1/2) and extracellular-signal-regulated kinases(ERK1/2) were also changed after JQ-R treatment compared with the control group. Together these findings suggest that JQ-R improved glucose and lipid metabolism in diabetic KK^(Ay)mice. JQ-R directly enhanced insulin-stimulated glucose uptake in insulin-resistant myotubes with improved insulin signalling and inflammatory response and oxidative stress. JQ-R could be a candidate to achieve improved glucose metabolism and insulin sensitivity in type 2 diabetes mellitus. | Quan Liu Shuainan Liu Lihui Gao Sujuan Sun Yi Huan Caina Li Yue Wang Nan Guo Zhufang Shen | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 11 |
| 11 | Devonian Sea-Level Change Rhythms in South China and Coupling Relationships Among the Earth-spheres显示文摘Twenty orthosequences and their corresponding sea-level change (SLC) cycles have been recognized in the Devonian overlying the Caledonian unconformity, of which 9, 5.5 and 5.5 occurred in the Lower, Middle and Upper Devonian respectively. They can be grouped into 4 orthosequence sets, in which the maximum flooding surfaces lie in the sulcutus Zone (D12), perbonus Zone (D13), Middle and Upper varcus Zone (D22) and gigas Zone (D21) respectively. Four instant palaeogeographical reconstructions of South China have been made in the Emsian and Givetian. Devonian sea-level change rhythms of South China can be divided into 3 categories: the autorhythmic, the worldwide and regional allorhythmic, and the coupling-rhythmic. They developed respectively in the Famennian, Pragian, Eifelian, Lochkovian, Emsian, Givetian, Frasnian and the F / F (between the Frasnian and Famennian) event. The cause of the worldwide allorhythmic SLC of the Pragian and Eifelian under comparatively dry, warm and tranquil conditions may | Gong Yiming,Faculty of Earth Science, China University of Geosciences, Wuhan,Hubei, 430074Wu Yi,Guangxi Institute of Geology, Nanning, GuangxiDu Yuansheng, Feng Qinglai and Liu BenpeiChina University of Geosciences, Wuhan, Hubei, 430074 | 1997 | Acta Geologica Sinica(English Edition)1997，71，4： | 10 |
| 12 | Hepatic artery complications after orthotopic liver transplantation: interventional treatment or retransplantation?显示文摘背景为在 orthotopic 肝移植(OLT ) 以后的肝的动脉复杂并发症的主要治疗学的治疗包括 thrombolysis,经皮的 transluminal angioplasty, stent 放置,和肝移植。在 OLT 以后的肝的动脉复杂并发症的预后与类型有关不仅,程度,并且预定而且仔细与选择联系了并且治疗学的方法预定。然而,没有关于这些复杂并发症的治疗的意见的一致。这研究的目的是在 25 个病人的临床的数据与肝的动脉血栓(帽子) 和肝的动脉狭窄诊断了的 OLT.Methods 以后为肝的动脉复杂并发症决定最佳的治疗() 在 2003 年 10 月和 2007 年 3 月之间回顾地被考察。治疗包括了包含 thrombolysis,经皮的 transluminal angioplasty 和 stent 放置的肝移植和干预。在有帽子的五个病人之中的结果, 3 与 thrombolysis 被对待。一个人恢复了,一个人在 thrombolysis 以后死了,因为周期性的帽子,另一一个在移植以后死于多器官失败。留下 2 个病人经历了成功的移植并且在那以后幸存。在介绍与的 12 个病人之中手术后地在 1 个月以内有, 2 个病人由于不可逆的肝失败和另外一个经历了移植 10 个病人与干预被对待。肝功能没能在 3 个病人改善,因为 ischemic 胆管炎,移植在 stent 放置以后在 4 个病人被执行。在经历肝移植的 6 个病人之中,二分别地死于 intracranial 出血和感染。介绍与的八个病人手术后地在 1 个月以后有, 5 个病人与 interventional 管理被对待并且在 stent 以后恢复了放置。在另外一个之中, 3 个病人介绍了与, 2 病人的肝功能是稳定的,一个病人由于 ischemic 胆汁管 lesion.Conclusions 收到了迟了的肝移植个性化的治疗学的政体应该在在 OLT 以后对待肝的动脉复杂并发症被采用根据手术后的时期,打字并且 ischemic 胆汁管损害是否存在。肝移植是为有肝的动脉血栓的病人的最好的治疗。Interventional 治疗没有不可逆的肝失败,近来有或胆汁管局部缺血是适当的,而移植被推荐为早。 | YANG Yang LI Hua FU Bin-sheng ZHANG Qi ZHANG Ying-cai LU Ming-qiang CAI Chang-jie XU Chi WANG Gen-shu YI Shu-hong ZHANG Jian ZHANG Jun-feng YI Hui-min JIANG Nan JIANG Hua ZHU Kang-shun JIANG Zai-bo SHAN Hong CHEN Gui-hua | 2008 | Chinese Medical Journal2008，，20： | 9 |
| 13 | Designing N-doped graphene/ReSe_(2)/Ti_(3)C_(2) MXene heterostructure frameworks as promising anodes for high-rate potassium-ion batteries显示文摘Developing high-performance anodes for potassium ion batteries(KIBs) is of paramount significance but remains challenging.In the normal sense,electrode materials are prepared by ubiquitous wet chemical routes,which otherwise might not be versatile enough to create desired heterostructures and/or form clean interfacial areas for fast transport of K-ions and electrons.Along this line,rate capability/cycling stability of resulting KIBs are greatly handicapped.Herein we present an all-chemical vapor deposition approach to harness the direct synthesis of nitrogen-doped graphene(NG)/rhenium diselenide(ReSe_2)hybrids over three-dimensional MXene supports as superior heterostructure anode material for KIBs.In such an innovative design,1 T'-ReSe2 nanoparticles are sandwiched in between the NG coatings and MXene frameworks via strong interfacial interactions,thereby affording facile K~+ diffusion,enhancing overall conductivity,boosting high-power performance and reinforcing structural stability of electrodes.Thus-constructed anode delivers an excellent rate performance of 138 mAh g^(-1) at 10.0 A g^(-1) and a high reversible capacity of 90 mAh g^(-1) at 5 A g^(-1) after 300 cycles.Furthermore,the potassium storage mechanism has been systematically probed by advanced in situlex situ characterization techniques in combination with first principles computations. | Zhou Xia Xiwen Chen Haina Cia Zhaodi Fan Yuyang Yi Wanjian Yin Nan Wei Jingsheng Cai Yanfeng Zhang Jingyu Sun | 2021 | Journal of Energy Chemistry2021，30，2： | 9 |
| 14 | A review of road extraction from remote sensing images显示文摘As a significant role for traffic management,city planning,road monitoring,GPS navigation and map updating,the technology of road extraction from a remote sensing(RS) image has been a hot research topic in recent years.In this paper,after analyzing different road features and road models,the road extraction methods were classified into the classification-based methods,knowledge-based methods,mathematical morphology,active contour model,and dynamic programming.Firstly,the road features,road model,existing difficulties and interference factors for road extraction were analyzed.Secondly,the principle of road extraction,the advantages and disadvantages of various methods and research achievements were briefly highlighted.Then,the comparisons of the different road extraction algorithms were performed,including road features,test samples and shortcomings.Finally,the research results in recent years were summarized emphatically.It is obvious that only using one kind of road features is hard to get an excellent extraction effect.Hence,in order to get good results,the road extraction should combine multiple methods according to the real applications.In the future,how to realize the complete road extraction from a RS image is still an essential but challenging and important research topic. | Weixing Wang Nan Yang Yi Zhang Fengping Wang Ting Cao Patrik Eklund | 2016 | Journal of Traffic and Transportation Engineering(English Edition)2016，3，3： | 9 |
| 15 | Sparse Representations for Speech Enhancement显示文摘 | ZHAO Nan XU Xin YANG Yi | 2011 | Chinese Journal of Electronics2011，20，2： | 9 |
| 16 | Synthesis and antitumor and antibacterial evaluation of fluoroquinolone derivatives(Ⅲ):Mono- and bis-Schiff-bases显示文摘To further explore an efficient modified route for the shift from an antibacterial fluoroquinolone to an antitumor one,mono-Schiff bases 6a-6h related to ciprofloxacin C3 carbonylhydrazone and bis-Schiff bases 4a-4h corresponding to C3/C7 carbonylhydrazone/hydrazone attached on a skeleton of ciprofloquinolone were designed and synthesized,and their in vitro antitumor activity against CHO,HL60,L1210 cells and antibacterial activity against Staphylococcus aureus and Escherichia coli were also reported. | Guo Qiang Hu Xiao Kui Wu Guo Qiang Wang Nan Nan Duan Xiao Yi Wen Tie Yao Cao Yin Jun Wang Wei Song Qiang Xie Wen Long Huang | 2012 | Chinese Chemical Letters2012，23，5： | 8 |
| 17 | Impact of CYP3A4*1G Polymorphism on Fentanyl Analgesia Assessed by Analgesia Nociception Index in Chinese Patients Undergoing Hysteroscopy显示文摘Background:The clinical efficacy of fentanyl for pain control differs greatly across individuals.The purpose of this study was to investigate the impact of CYP3A4*1G polymorphism including wild-type homozygote (CYP3A4*1/*1,GG),mutant heterozygote (CYP3A4*1/*1G,GA),and mutant homozygote (CYP3A4*1G/*1G,AA)on fentanyl analgesia in Chinese patients undergoing hysteroscopy by the assessment of analgesia nociception index (ANI). Methods:A total of 200 gynecologic patients scheduled for elective hysteroscopy under general anesthesia at Peking University People's Hospital from May to December in 2017 were enrolled in this study.Venous blood was withdrawn for genotyping of CYP3A4*1G before operation.Fentanyl 1μg/kg was administered preoperatively followed by target-controlled infusion of propofol for induction and maintenance.Intraoperative analgesic efficacy of fentanyl was assessed by ANI monitoring at T0(entering room),T1(cervical dilation), T2(start of cervical aspiration),and T3(end of cervical aspiration)time points.The duration of propofol infusion and total dosage of propofol were recorded as well. Results:The patients were divided into three groups according to CYP3A4*1G polymorphism,including 143 in GG group,47in GA group, and 10 in AA group.There was no significant difference in clinical demographics among three groups.The frequency of CYP3A4*1G variant alleles accounted for 16.8%and the distribution of variant alleles was consistent with Hardy-Weinberg equilibrium.Using a multilevel model,ANI values at T1(63.81±19.61),T2(63.63±17.82),and T3(65.68±17.79)were significantly lower than that at T0 (77.16±12.93)in the study population (F =23.50,P <0.001),suggesting that higher levels of pain at T 1,T2,and T3 than T0.Patients with GG genotype showed significantly lower ANI than those with GA or AA genotypes during hysteroscopy under the same dose of fentanyl. Conclusion:CYP3A4*1G polymorphism associated with the analgesic efficacy of intraoperative fentanyl in the patients undergoing hysteroscopy under general anesthesia. | Qi Yan Yi Su Lan Gao Nan Ding Hong-Ying Zhang Wen E Yue Wang Yi Feng Hai-Yan An | 2018 | Chinese Medical Journal2018，，22： | 8 |
| 18 | APE1 polymorphisms are associated with colorectal cancer susceptibility in Chinese Hans显示文摘AIM:To study the association between four base excision repair gene polymorphisms and colorectal cancer risk in a Chinese population.METHODS:Two hundred forty-seven colorectal cancer(CRC)patients and three hundred cancer-free controls were enrolled in this study.Four polymorphisms(OGG1Ser326Cys,APE1 Asp148Glu,-141T/G in the promoter region,and XRCC1 Arg399Gln)in components of the base excision repair pathway were determined in patient blood samples using polymerase chain reaction with confronting two-pair primers.The baseline information included age,gender,family history of cancer,and three behavioral factors[smoking status,alcohol consumption,and body mass index(BMI)].χ2tests were used to assess the Hardy-Weinberg equilibrium,the distributions of baseline characteristics,and the four gene polymorphisms between the cases and controls.Multivariate logistic regression analyses were conducted to analyze the correlations between the four polymorphisms and CRC risk,adjusted by the baseline characteristics.Likelihood ratio tests were performed to analyze the gene-behavior interactions of smoking status,alcohol consumption,and BMI on polymorphisms and CRC susceptibility.RESULTS:The APE1 148 Glu/Glu genotype was significantly associated with an increased risk of colorectal cancer(OR=2.411,95%CI:1.497-3.886,P<0.001relative to Asp/Asp genotype).There were no associations between OGG1,XRCC1,or APE1 promoter polymorphisms and CRC risk.A multivariate analysis including three behavioral factors showed that the APE1 148Glu/Glu genotype was associated with an increased risk for CRC among both smokers and non-smokers,non-drinkers and individuals with a BMI≥25 kg/m2(ORs=2.356,3.299,2.654,and 2.581,respectively).The XRCC1 399 Arg/Gln genotype was associated with a decreased risk of CRC among smokers and drinkers(OR=0.289,95%CI:0.152-0.548,P<0.001,and OR=0.327,95%CI:0.158-0.673,P<0.05,respectively).The APE1 promoter polymorphism-141 T/G genotype was associated with a reduced risk of colorectal cancer among subjects with a BMI<25 kg/m2(OR=0.214,95%CI:0.069-0.660,P<0.05 relative to T/T genotype).There were significant gene-behavior interactions between smoking status and XRCC1 Arg399Gln,as well as BMI and APE1-141T/G polymorphism(all P<0.05).CONCLUSION:APE1 Asp148Glu is associated with increased CRC risk and smoking alters the association between XRCC1 Arg399Gln and CRC risk in the Chinese Han population. | Shi-Heng Zhang Lin-Ang Wang Zheng Li Yu Peng Yan Ping Cun Nan Dai Yi Cheng He Xiao Yan-Li Xiong Dong Wang | 2014 | World Journal of Gastroenterology2014，20，26： | 8 |
| 19 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 20 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
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