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| 1 | Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing显示文摘Targeting immune checkpoints such as programmed cell death protein 1(PD-1)and programmed death ligand-1(PD-L1)have been approved for treating melanoma,gastric cancer(GC)and bladder cancer with clinical benefit.Nevertheless,many patients failed to respond to anti-PD-1/PD-L1 treatment,so it is necessary to seek an alternative strategy for traditional PD-1/PD-L1 targeting immunotherapy.Here with the data from The Cancer Genome Atlas(TCGA)and our in-house tissue library,PD-L1 expression was found to be positively correlated with the expression of ubiquitin-specific processing protease 7(USP7)in GC.Furthermore,USP7 directly interacted with PD-L1 in order to stabilize it,Gastric cancer;Immunosuppression;Cancer biologywhile abrogation of USP7 attenuated PD-L1/PD-1 interaction and sensitized cancer cells to T cell killing in vitro and in vivo.Besides,USP7 inhibitor suppressed GC cells proliferation by stabilizing P53 in vitro and in vivo.Collectively,our findings indicate that in addition to inhibiting cancer cells proliferation,USP7 inhibitor can also downregulate PD-L1 expression to enhance anti-tumor immune response simultaneously.Hence,these data posit USP7 inhibitor as an anti-proliferation agent as well as a novel therapeutic agent in PD-L1/PD-1 blockade strategy that can promote the immune response of the tumor. | Zhiru Wang Wenting Kang Ouwen Li Fengyu Qi Junwei Wang Yinghua You Pengxing He Zhenhe Suo Yichao Zheng Hong-Min Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 5 |
| 2 | Melanin nanoparticles alleviate sepsis-induced myocardial injury by suppressing ferroptosis and inflammation显示文摘Myocardial injury as one of the severe complications leads to the increasing morbidity and mortality in patients with sepsis.Recent studies reported that reactive oxygen species(ROS)-mediated ferroptosis plays a critical role in the development of heart diseases.Therefore,we hypothesized that anti-ferroptosis agent might be a novel potential therapeutic strategy for sepsis-induced cardiac injury.Herein,we demonstrated that a small biocompatible and MRI-visible melanin nanoparticles(MMPP)improves myocardial function by inhibiting ROS-related ferroptosis signaling pathway.In LPS-induced murine sepsis model,after a single dose intravenously injection of MMPP treatment,MMPP markedly alleviated the myocardial injury including cardiac function and heart structure disorder through suppressing iron-accumulation induced ferroptosis.In vitro,MMPP inhibited cardiomyocyte death by attenuating oxidative stress,inflammation and maintaining mitochondrial homeostasis.Collectively,our findings demonstrated that MMPP protected heart against sepsis-induced myocardial injury via inhibiting ferroptosis and inflammation,which might be a novel therapeutic approach in future. | Chang Liu Quan Zou Huixin Tang Jia Liu Shiqi Zhang Caihong Fan Junwei Zhang Ruiqing Liu Yashan Liu Ruiyan Liu Yan Zhao Qiang Wu Zhi Qi Yanna Shen | 2023 | Bioactive Materials2023，，6： | 5 |
| 3 | PEPT1-mediated prodrug strategy for oral delivery of peramivir显示文摘Peramivir was a novel and highly potent neuraminidase(NA) inhibitor for the treatment of influenza A and B. However, it exhibited a very low oral bioavailability(only 3%) due to the high polarity(log P of-1.4) and the low membrane permeability across the intestine. To utilize the PEPT1-mediated prodrug strategy to improve the oral absorption and develop the oral alternative, seven amino acid ester prodrugs and seven amino acid amide prodrugs have been synthesized. The permeability of these prodrugs across Caco-2 cells were screened. Peramivr-(CH_2)_2-l-Val and Peramivir-l-Ile were of the highest permeability in ester prodrugs and amide prodrugs, respectively, and then they were selected for further studies. Glycylsarcosine(gly-sar) uptake by Caco-2 could be inbihited by Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile in a concentration-dependent manner, and the IC 50 was 1.34 ± 0.31 m M and 1.78 ± 0.48 m M, respectively. The direct uptake of Peramivir-(CH_2)_2-l-Val and Peramivirl-Ile in MDCK-PEPT1 cells were significantly higher than in MDCK mock cells, and could be markedly inhibited by gly-sar. The uptake of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile(0.01 to 50 m M) in MDCK-hPEPT1 cells conformed to Michaelis–Menten Equation. The oral bioavailability of peramivir was 65.3% and 37.3% after the oral administration of Peramivir-(CH_2)_2-l-Val and Peramivir-l-Ile to rats, respectively. The oral absorption and bioactivation of Peramivir-(CH_2)_2-l-Val was rapid and extensive, and no Peramivir-(CH_2)_2-l-Val was found in plasma. Because the amide bond was relatively stable, Peramivir-l-Ile could not be totally converted to the parent drug in vivo. Peramivir-(CH_2)_2-l-Val with good oral profiles and rapid bioactivation might be a promising prodrug for the further clinic development. The present study also corroborated the idea that the PEPT1-mediated prodrug approach has enormous promise for improving the oral absorption of poorly absorbed drug. | Yongbing Sun Wei Gan Mingdao Lei Wei Jiang Meng Cheng Junwei He Qi Sun Wan Liu Lvjiang Hu Yi Jin | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 4 |
| 4 | Study on the Influence of Airgun Excitation Conditions on Airgun Signals and Travel Time Variation Measurements显示文摘Because of the different excitation conditions of the airgun source,there will be subtle differences in airgun signals.Travel time variation of airgun signals often mix into source information which can’t fully reflect the evolution of the medium.This article uses the airgun signals from the Binchuan Transmitting Seismic Station to analyze the airgun signal′s characteristics of phase and correlation.We conducted a comparative analysis of the effects of the pair difference method and the deconvolution method on eliminating the influence of the excitation conditions in travel time variation.The results show that:(1)The pressure pulse and its subsequent wave of airgun source wavelet are less affected by excitation conditions that we can use it to obtain high-precision excitation moments.(2)Deconvolution can improve the correlation of the airgun signal.(3)The pair difference method can’t eliminate the influence of excitation conditions in travel time variation.Deconvolution can reduce excitation condition interference and the influence of the excitation condition in the travel time variation after deconvolution of the vertical signal is significantly reduced. | XIANG Ya YANG Runhai WANG Bin ZHOU Yunyao LU Yongqing WU Huan QI Junwei PENG Jing | 2019 | Earthquake Research in China2019，33，2： | 3 |
| 5 | BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc显示文摘 | Jake E. Delmore Ghayas C. Issa Madeleine E. Lemieux Peter B. Rahl Junwei Shi Hannah M. Jacobs Efstathios Kastritis Timothy Gilpatrick Ronald M. Paranal Jun Qi Marta Chesi Anna C. Schinzel Michael R. McKeown Timothy P. Heffernan Christopher R. Vakoc P. Lei | 2011 | Cell2011，，6： | 3 |
| 6 | Study on an automatic multi-pin insertion system for preparing Z-pin composite laminates显示文摘As a three-dimensional layer enhancement technology, the Z-pin technology is suitable for manufacturing composite prepreg laminates and can also effectively improve their interlaminar properties. In order to manufacture Z-pin composite parts efficiently, this paper proposes a transitional insertion system, and according to the technical requirements of the transitional insertion process and the functional requirements of the transitional insertion platform, proposes a transition insertion plan which can insert multiple Z-pins into a carrier. A prototype machine has been designed and made, and a series of function debugging and verification experiments have been carried out on the machine. Some problems show up during the experiments, but based on the analysis of the reasons, this paper provides lots of solutions, and finally demonstrates the feasibility and practical value of the system. The results show that the system meets all technical requirements of the Z-pin insertion process. It is capable to insert multiple Z-pins into a foam carrier; as a result, the system is as much as 5 times more efficient than existing equipment, and the deviation for the insertion distance can be controlled within 0.3 mm. This Z-pin transitional insertion platform promotes the use of Z-pins in national defense and lays the foundation for commercializing the Z-pin technology. | Song Qinghua Li Yong Qi Junwei Wen Liwei Xiao Jun Ni Jinhui | 2014 | Chinese Journal of Aeronautics2014，27，2： | 2 |
| 7 | Changes and postharvest regulation of activity and gene expression of enzymes related to cell wall degradation in ripening apple fruit显示文摘 | Jianmei Wei Fengwang Ma Shouguo Shi Xiudong Qi Xiangqiu Zhu Junwei Yuan | 2009 | Postharvest Biology and Technology2009，，2： | 2 |
| 8 | Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration显示文摘 | Yujing Zhang Danqing Liu Xi Chen Jing Li Limin Li Zhen Bian Fei Sun Jiuwei Lu Yuan Yin Xing Cai Qi Sun Kehui Wang Yi Ba Qiang Wang Dongjin Wang Junwei Yang Pingsheng Liu Tao Xu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Molecular Cell2010，，1： | 2 |
| 9 | Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration显示文摘 | Yujing Zhang Danqing Liu Xi Chen Jing Li Limin Li Zhen Bian Fei Sun Jiuwei Lu Yuan Yin Xing Cai Qi Sun Kehui Wang Yi Ba Qiang Wang Dongjin Wang Junwei Yang Pingsheng Liu Tao Xu Qiao Yan Junfeng Zhang Ke Zen Chen-Yu Zhang | 2010 | Molecular Cell2010，，1： | 1 |
| 10 | Space Charge Suppression of Polyethylene Induced by Blending with Ethylene-butyl Acrylate Copolymer显示文摘High-voltage direct current(HVDC)power cables have been paid more attention due to the big issue concerning the main insulation materials.The residues in the industrial production process will cause space charge generation and accumulation in the materials,which has become one bottleneck to limit the development of power cables up to higher voltage levels.In this paper,the LDPE matrix was modified by three types of ethylene-butyl acrylate(EBA)copolymers(1.0 wt%)with different polarities(BA content)via melt blending to optimize the space charge behavior of the LDPE insulation.The micromorphology and structure of the blends are examined by polarized light microscope and differential scanning calorimetry.The space charge distribution is tested by the pulsed electro-acoustic method.The trap level is studied by the thermally stimulated current.The results show that EBA introduces more deep traps and decreases the shallow traps.The medium-polar EBA(16%BA content)can effectively suppress charge accumula-tion,and have the same suppressed effect on XLPE/EBA blends.This study will provide important insights into the design and development of advanced HVDC power cable applications. | Jintao Zhai Weikang Li Junwei Zha Qi Cheng Xingming Bian Zhimin Dang | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 1 |
| 11 | Changes and postharvest regulation of activity and gene expression of enzymes related to cell wall degradation in ripening apple fruit显示文摘 | Jianmei Wei Fengwang Ma Shouguo Shi Xiudong Qi Xiangqiu Zhu Junwei Yuan | 2009 | Postharvest Biology and Technology2009，，2： | 1 |
| 12 | 6 - 18 Operation Status of On-line Ion Sources in 2012显示文摘 | FengYucheng Lu Wang Li Jinyu Zhang Wenhui Ma Hongyi Ma Baohua Wang Hui Li Jiaqing Lin Shuhao Cao Yun Sha Shan W u Qi Guo Junwei Fang Xing Yang Yao Li Xixia Zhang Hengjuan Zhao Huanyu Zhang Xuezhen Sun Liangting Zhao Hongwei | 2012 | IMP & HIRFL Annual Report2012，，1： | 1 |
| 13 | Changes in platelet parameters and secondary brain injury in acute craniocerebral trauma显示文摘Changes in platelet parameters are important in secondary brain injury in acute craniocerebral trauma.We selected 163 patients with craniocerebral trauma who were admitted within 24 hours with nonoperative therapy.Platelet parameters of 40 healthy subjects served as controls.Platelet number was decreased,while mean platelet volume and platelet distribution width values were increased,at 1 and 3 days after injury.Platelet number was lower and mean platelet volume and platelet distribution width were larger in patients with traumatic cerebral infarction and those in Glasgow Coma Scale score < 8 group.Platelet number was negatively correlated to volume of cerebral edema,but positively correlated to Glasgow Outcome Scale score.These data indicate that changes in platelet parameters may be utilized to indicate the state of central nervous system injury and patient prognosis. | Xiaoping Tang Chao You Hua Peng Tao Zhang Wenguo Tang Jian Qi Renguo Luo Yuanchuan Wang Ling Feng Zhangyang Gou Junwei Duan Shun Li | 2011 | Neural Regeneration Research2011，6，20： | 0 |
| 14 | BoMyrosinase plays an essential role in sulforaphane accumulation in response to selenite treatment in broccoli显示文摘Sulforaphane, a naturally specialized metabolite, plays significant roles in human disease prevention and plant defense. Myrosinase(MY) is a key gene responsible for the catalysis of sulforaphane formation, but the molecular mechanisms through which MY regulates sulforaphane biosynthesis in plants remains largely unknown. Here, we discovered that the change of sulforaphane content in broccoli sprouts caused by exogenous selenite treatments is positively related to BoMY expression. BoMY overexpression in the Arabidopsis thaliana tgg1 mutants could dramatically increase myrosinase activity and sulforaphane content in the rosette leaves of 35S::BoMY/tgg1 and rescue its phenotypes.Moreover, an obvious increase of myrosinase activity and sulforaphane content was displayed in transgenic BoMY-overexpressed broccoli lines.In addition, a 2 033 bp promoter fragment of BoMY was isolated. Yeast one-hybrid(Y1H) library screening experiment uncovered that one bHLH transcription factor, BoFAMA, could directly bind to BoMY promoter to activate its expression, which was further evidenced by Y1H assay and dual-luciferase reporter assay. BoFAMA is a selenite-responsive transcription factor that is highly expressed in broccoli leaves;its protein is solely localized to nucleus. Additionally, genetic evidence suggested that the knockdown of FAMA gene in Arabidopsis thaliana could significantly decrease sulforaphane yield by inhibiting the expression of myrosinase genes. Interestingly, exogenous selenite supply could partially restore the low level of sulforaphane content in transgenic Arabidopsis FAMA-silencing plants. Our findings uncover a novel function of FAMAMY module in the regulation of selenite-mediated sulforaphane synthesis and provide a new insights into the molecular mechanism by which selenite regulates the accumulation of sulforaphane in plants. | Qiuyun Wu Qi Wu Yuxiao Tian Chunyan Zhou Shuxiang Mao Junwei Wang Ke Huang | 2024 | Horticultural Plant Journal2024，10，2： | 0 |
| 15 | 6-13 Summary of Ion Source Group in 2015显示文摘Ion source as one very unique and critical part of ion accelerator needs consistent research and development work to improve the performance and to meet the future accelerator needs as well. The ion source group at IMP is taking the responsibility of high performance intense beam ion source development, operation and exploration. | Sun Liangting Feng Yucheng Lu Wang Qian Cheng Zhang Wenhui Wu Qi Yang Yao Guo Junwei Zhao Huanyu Cao Yun Zhang Xuezhen Zhao Hongwei | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 16 | Development of an indirect immunofluorescence assay for PCV3 antibody detection based on capsid protein显示文摘Porcine circovirus type 3(PCV3)is a novel porcine circovirus associated with porcine dermatitis and nephritis syndrome(PDNS),reproductive failure,and multisystemic inflammation.Capsid protein(Cap)encoded by PCV3 ORF2 gene has been identified as an immunogenic protein.Currently,there is no immunofluorescence assay(IFA)available for serological diagnosis.Here,the N-terminal 33 amino acids of Cap protein were predicted to serve as a PCV3 nuclear localization signal(NLS).Two types of recombinant plasmids were constructed for recombinant protein expression in 5f9 cells by using a baculovirus expression system:plasmid rvBac-Pc for full-length Cap protein expression and rvBac-Sc for Cap protein expression with a honeybee melittin signal peptide in place of the predicted NLS sequence.Expression of the nuclear localization sequences was further analyzed by IFA.Strong and specific fluorescence signals were observed in the nucleus of rvBac-Pc-transfected cells and in the cytoplasm of rvBac-Sc-transfected cells.No cross-reactivity was observed with porcine circovirus type 2,porcine pseudorabies virus,classical swine fever virus,or porcine reproductive and respiratory syndrome virus.In summary,we developed two fluorescence detection modes for Cap protein that can be used to detect PCV3 antibodies.This method is suitable for the diagnosis and epidemiological investigation of PCV3.This study provides a reliable detection method for monitoring PCV3 antibody level in pigs in the future. | Lun Yao Chang Li Junwei Wang Yufang Cheng Ahmed H.Ghonaim Qi Sun Xuexiang Yu Weijie Niu Shengxian Fan Qigai He | 2021 | Animal Diseases2021，1，2： | 0 |
| 17 | In situ growth of phosphorized ZIF-67-derived amorphous CoP/Cu_(2)O@CF electrocatalyst for efficient hydrogen evolution reaction显示文摘Transition metal phosphides have been extensively studied for catalytic applications in water splitting.Herein,we report an in situ phosphorization of zeolitic imidazole frameworks(ZIF-67)to generate amorphous cobalt phosphide/ZIF-67 heterojunction on a self-supporting copper foam(CF)substrate with excellent performance for hydrogen evolution reaction(HER).The needleleaf like copper hydroxide was anchored on CF surface,which acted as implantation to grow ZIF-67.The intermediate product was phosphorized to obtain final electrocatalyst(CoP/Cu_(2)O@CF)with uniform particle size,exhibiting a rhombic dodecahedron structure with wrinkles on the surface.The electrochemical measurement proved that CoP/Cu_(2)O@CF catalyst exhibited excellent HER activity and long-term stability in 1.0 mol·L^(–1)KOH solution.The overpotential was only 62 mV with the Tafel slope of 83 mV·dec^(–1)at a current density of 10 mA·cm^(–2),with a large electrochemical active surface area.It also showed competitive performance at large current which indicated the potential application to industrial water electrolysis to produce hydrogen.First-principle calculations illustrated that benefit from the construction of CoP/ZIF-67 heterojunction,the d-band center of CoP downshifted after bonding with ZIF-67 and the Gibbs free energy(ΔGH*)changed from–0.18 to–0.11 eV,confirming both decrease in overpotential and excellent HER activity.This work illustrates the efficient HER activity of CoP/Cu_(2)O@CF catalyst,which will act as a potential candidate for precious metal electrocatalysts. | Ruiwen Qi Xiao Liu Hongkai Bu Xueqing Niu Xiaoyang Ji Junwei Ma Hongtao Gao | 2023 | Frontiers of Chemical Science and Engineering2023，17，10： | 0 |
| 18 | 离子源室2018年工作总结显示文摘Ion sources have fundamental impacts to the operation status of existing facilities and research progress of those under construction.In 2018,totally 6825.5 h beam time has been made by the ion sources for HIRFL operation,contributed by superconducting ECR ion source SECRAL/SECRAL-II with 2231 h and room temperature ECR ion source LECR3 with 4594.5 h respectively.Totally 19 beams of different ions or energies have been delivered to the downstream accelerators for diverse experiments covering the research fields of nuclear physics,material irradiation,medical application and so on.Highlights of the on-line ion source operation are the successful production of stable 7Li3+and 181Ta31+ion beams for HIRFL,and the on-line operation of SECRAL-II by replacing the former injector ion source SECRAL(Fig.1). | Sun Liangting Guo Junwei Zhao Huanyu Feng Yucheng Qian Cheng Zhang Wenhui Yang Yao Wu Qi Ma Hongyi Cao Yun Li Jiaqing Lu Wang Zhang Xuezhen Zhao Hongwei | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 19 | Comprehensive Evaluation of New Fresh Edible Sweet-glutinous Maize Varieties Based on Entropy Weight Method显示文摘In this study,the entropy weight method was used to comprehensively evaluate the eight sweet-glutinous maize varieties in the regional trials in Shanxi Province in 2016. The results showed that the order of the performance of comprehensive traits of the tested varieties was Heitiannuo 631,Heitiannuo No. 2,Cainuo No. 5,Xinnuo 8601,FYN 1601,Xinnuo 8608,Jindannuo 41,Caitiannuo 1958( from good to poor). Among them,Heitiannuo 631,Heitiannuo No. 2 and Cainuo No. 5 are excellent varieties,and the rest are good varieties. | Junwei YANG Jianjun WANG Linsheng SHAO Yanliang LI Bianping ZHAO Xin JIA Qi LUO | 2018 | Asian Agricultural Research2018，10，11： | 0 |
| 20 | Summary of Ion Source Group Work in 2019显示文摘Ion Source Group are taking the responsibilities of ion source development,routine operation,ion beam platform commissioning and ion beam application research. | Sun Liangting Lu Wang Guo Junwei Zhao Huanyu Feng Yucheng Qian Cheng Zhang Wenhui Yang Yao Wu Qi Ma Hongyi Cao Yun Li Jiaqing Zhang Xuezhen Zhao Hongwei | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
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