| 1 | Morphological MRI and T2 mapping of cartilage repair tissue after mosaicplasty with tissue-engineered cartilage in a pig model显示文摘The aim of this study was to evaluate the efficacy of mosaicplasty with tissue-engineered cartilage for the treatment of osteochondral defects in a pig model with advanced MR technique.Eight adolescent miniature pigs were used.The right knee underwent mosaicplasty with tissue-engineered cartilage for treatment of focal osteochondral defects,while the left knee was repaired via single mosaicplasty as controls.At 6,12,18 and 26 weeks after surgery,repair tissue was evaluated by magnetic resonance imaging(MSI)with the cartilage repair tissue(MOCART)scoring system and T2mapping.Then,the results of MRI for 26 weeks were compared with findings of macroscopic and histologic studies.The MOCART scores showed that the repaired tissue of the tissue-engineered cartilage group was statistically better than mat of controls(P<0.001).A significant correlation was found between macroscopic and MOCART scores(P<0.001).Comparable mean T2 values were found between adjacent cartilage and repair tissue in the experimental group(P>0.05).For zonal T2 value evaluation,there were no significant zonal T2 differences for repair tissue in controls(P>0.05).For the experimental group,zonal T2 variation was found in repair tissue(P<0.05).MRI,macroscopy and histology showed better repair results and bony incorporation in mosaicplasty with the tissue-engineered cartilage group than those of the single mosaicplasty group.Mosaicplasty with the tissue-engineered cartilage is a promising approach to repair osteochodndral defects.Morphological MRI and T2 mapping provide a non-invasive method for monitoring the maturation and integration of cartilage repair tissue in vivo. | Qichun Chen Qiang Zuo Qianqian Hu Yang Feng Weiding Cui Weimin Fan Yuefen Zou | 2014 | The Journal of Biomedical Research2014，28，4： | 2 |
| 4 | Coupling of sulfur and boron in carbonaceous material to strengthen persulfate activation for antibiotic degradation:Active sites,mechanism,and toxicity assessment显示文摘Carbon-mediated persulfate advanced oxidation processes(PS-AOPs)are appealing in contaminant remediation.For the first time,S,B-co-doped carbon-based persulfate activators were synthesized through direct carbonization of sodium lignosulfonate and boric acid.By degrading sulfamethoxazole(SMX),CSB-750 obtained 98.7%removal and 81.4%mineralization within 30 min.In comparison with solo S or B doping,S and B co-doped carbon showed the coupling effect for enhanced catalysis.The rate constant(kobs)of 0.1679 min^(-1)was 22.38-and 279.83-fold higher than those of CS-750(0.0075 min^(-1))and CB-750(0.0006 min^(-1)),respectively.The degradation was efficient at strong acidic and weak basic conditions(pH 3-9).Substantial inhibition effect was presented at strong basic condition(pH 10.95)and in presence of CO_(3)^(2-).The CO_(3)^(2-)-caused inhibition was the combined result of the cooperation of pH and quenching O_(2)^(·-).Thiophene sulfur,BC_(3),BC_(2)O,and structural defects were identified as the active sites for PS activation.Radical and nonradical pathways were both involved in the CSB-750/PS/SMX system,where^(1)O_(2)dominated the degradation,SO_(4)^(·-),·OH and direct electron transfer played the subordinate role,and O_(2)^(·-)served as a precursor for the formation of partial^(1)O_(2).The toxicity of degradation system,the effect of real water matrix,and the reusability of carbocatalysts were comprehensively analyzed.Nine possible degradation pathways were proposed.This work focuses on the catalytic performance improvement through the coupling effect of S,B co-doping,and develops an advanced heteroatom doping system to fabricate carbonaceous persulfate activators. | Feng Ye Wei Sun Kangfeng Pang Wenchao Yang Mengjie Pu Qichun Zhang | 2023 | Chinese Chemical Letters2023，34，5： | 0 |
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