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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Solute-homogenization model and its experimental verification in Mg-Gd-based alloys显示文摘Composition homogenization in solid solution is important for industrial alloys. In the present work, a solute homogenization model is proposed based on the chemical short-range-order tendency in Mg-Gdbased alloys. After a calculation using the cluster-plus-glue-atom model, the stable Mg-Gd structural unit is derived, [Gd-Mg12]Mg6, where one solute Gd is nearest-neighbored with twelve Mg atoms to form the characteristic hcp cluster [Gd-Mg12] and this cluster is matched with six Mg glue atoms. Such a local unit is then mixed with [Mg-Mg12]Mg3, the stable unit for pure Mg. Assuming that the Gd-containing units are arranged in fcc-or bcc-like lattice points and the Mg units in their octahedral interstices, three proportions between the two units are obtained, 1:1, 2:3, and 1:3, which constitute three solute homogenization modes. The prevailing Mg-Gd-based alloys are consequently classified into three groups, respectively exemplified by GW103 K(Mg-10 Gd-3 Y-0.4 Zr, wt%), GW83 K(Mg-8 Gd-3 Y-0.4 Zr), and GW63 K(Mg-6 Gd-3 Y-0.4 Zr). Mg-Gd-Y-Zr alloys were designed following the model(where Y and Zr were also added in substitution for Gd) and prepared by permanent-mould casting. According to their mechanical properties,the 1:3 alloy(Mg-5.9 Gd-1.6 Y-0.4 Zr) shows the best comprehensive properties(ultimate tensile strength305 MPa, yield strength 186 MPa, elongation 9.0%) in solution plus ageing state. | Shengnan Qian Chuang Dong Tianyu Liu Ying Qin Qing Wang Yujuan Wu Lidong Gu Jianxin Zou Xiangwen Heng Liming Peng Xiaoqin Zeng | 2018 | Journal of Materials Science & Technology2018，34，7： | 6 |
| 3 | Shenkang injection improves coagulation in patients with chronic kidney disease: a systematic review and Meta-analysis显示文摘OBJECTIVE: To investigate the effect of Shenkang injection(SKI) on chronic kidney disease(CKD).METHODS: Seven databases including Cochrane Central Register of Controlled Trials, PubMed, EMBASE, MEDLINE, China National Knowledge Infrastructure, Wanfang Database, and CQVIP from their inception to March 2018 were searched. Only randomized controlled trials that evaluated conventional treatment and conventional treatment with SKI in CKD patients were investigated. Outcomes such as fibrinogen(FIB), D-dimer, prothrombin time(PT), activated partial thromboplastin time(APTT), and the side effects of SKI were analyzed using Revman 5.3 software. The quality of the studies was assessed using the Cochrane Collaboration’s Risk of Bias tool and the quality of evidence was assessed using GRADEpro.RESULTS: Four randomized controlled trials were investigated in our analysis, and these studies were of moderate quality. For FIB and D-dimer, SKI had a superior effect compared with the control group(mean difference(MD)=-1.23, 95% confidence interval(CI):-1.46,-0.99, P < 0.01;MD =-0.36, 95%CI:-0.51,-0.21, P < 0.01, respectively)SKI increased APTT and PT compared with the control(MD = 7.34, 95% CI: 3.05, 11.62, P < 0.01;MD = 3.40,95% CI: 2.2, 4.61, P < 0.01, respectively). In the four studies, there were no side effects that were related to SKI.CONCLUSION: SKI may be effective in improving coagulation in patients with CKD without obvious adverse reactions. However, more well-designed studies are required to confirm the findings. | Song Zilin Qin Tianyu Pan Yajing Hua Qian Wu Lili Liu Tonghua | 2019 | Journal of Traditional Chinese Medicine2019，39，4： | 3 |
| 4 | Chromobox homolog 4 overexpression inhibits TNF-α-induced matrix catabolism and senescence by suppressing activation of NF-κB signaling pathway in nucleus pulposus cells显示文摘Intervertebral disc degeneration(IDD)is featured as enhanced catabolism of extracellular matrix(ECM)in the nucleus pulposus(NP),in which tumor necrosis factor-alpha(TNF-α)-related cell senescence is involved.Chromobox homolog protein 4(CBX4)exhibits anti-inflammatory effects and shows promising therapeutic potential.Thus,in the present study,we explore the role of CBX4 in IDD.Immunohistochemistry staining reveals that CBX4 expression is decreased in severe degenerative NP tissues compared to mild degenerative tissues,and real-time PCR and western blot analysis results show that CBX4 expression is downregulated under TNF-αstimulation in NP cells.siRNA and adenoviruses are used to knockdown or overexpress CBX4,respectively.The results demonstrate that CBX4 knockdown augments the catabolism of ECM in human NP cells,while CBX4 overexpression in rat NP cells restores the ECM degradation induced by TNF-α,as illustrated by immunofluorescence and western blot analysis.In addition,transcriptome sequencing results reveal the regulatory effect of CBX4 on the cell cycle,and further western blot analysis and senescence-associatedβ-galactosidase staining assay indicate that CBX4 overexpression alleviates cell senescence in the presence of TNF-α.Moreover,the phosphorylation of p65,which indicates the activation of NF-κB signaling,is measured by western blot analysis and immunofluorescence assay,and the results reveal that CBX4 overexpression reduces the TNF-α-induced increase in the p-p65/p65 ratio.In addition,the effect of CBX4 overexpression in NP cells is suppressed by NF-κB agonist.In summary,our results indicate that CBX4 overexpression can suppress TNF-α-induced matrix catabolism and cell senescence in the NP by inhibiting NF-κB activation.This study may provide new approaches for preventing and treating IDD. | Yangyang Zhang Shuangxing Li Junmin Hong Jiansen Yan Zhengqi Huang Jiajun Wu Zhihuai Deng Tianyu Qin Kang Xu Wei Ye | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 2 |
| 5 | DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2显示文摘Metastasis is a major cause of colorectal cancer(CRC)mortality,but its molecular mechanisms are still not fully understood.Here,we show that upregulated DDX39B correlates with liver metastases and aggressive phenotypes in CRC.DDX39B is an independent prognostic factor associated with poor clinical outcome in CRC patients.We demonstrate that Sp1 potently activates DDX39B transcription by directly binding to the GC box of the DDX39B promoter in CRC cells.DDX39B overexpression augments the proliferation,migration,and invasion of CRC cells,while the opposite results are obtained in DDX39B-deficient CRC cells.Mechanistically,DDX39B interacts directly with and stabilizes PKM2 by competitively suppressing STUB1-mediated PKM2 ubiquitination and degradation.Importantly,DDX39B recruits importin a5 to accelerate the nuclear translocation of PKM2 independent of ERK1/2-mediated phosphorylation of PKM2,leading to the transactivation of oncogenes and glycolysis-related genes.Consequently,DDX39B enhances glucose uptake and lactate production to activate Warburg effect in CRC.We identify that Arg319 of DDX39B is required for PKM2 binding as well as PKM2 nuclear accumulation and for DDX39B to promote CRC growth and metastasis.In addition,blocking PKM2 nuclear translocation or treatment with glycolytic inhibitor 2-deoxy-D-glucose efficiently abolishes DDX39B-triggered malignant development in CRC.Taken together,ourfindings uncover akey role forDDX39B in modulating glycolytic reprogramming and aggressive progression,and implicate DDX39B as a potential therapeutic target in CRC. | Gang Zhao Hang Yuan Qin Li Jie Zhang Yafei Guo Tianyu Feng Rui Gu Deqiong Ou Siqi Li Kai Li Ping Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 6 | Enhancing the activity of FeNi bimetallic electrocatalysts on overall water splitting by Nd_(2)O_(3)-induced FeNi lattice contraction显示文摘The development of high-efficiency and cost-effective bifunctional electrocatalysts for overall water splitting remains a formidable challenge.Herein,FeNi-Nd_(2)O_(3) nanoparticles anchored on N-doped carbon nanotubes(FeNi-Nd_(2)O_(3)/NCN) are designed for highly effective overall water splitting via a facile two-step hydrothermal approach.The synthetic FeNi-Nd_(2)O_(3) hetero-trimers(Fe 2p-Ni 2p-Nd 3d orbital coupling)on NCN achieve excellent oxygen evolution reaction(OER) and hydrogen evolution reaction(HER) activities with overpotentials of 270 and 120 mV at 10 mA cm^(-2) in 1 M KOH solution.Moreover,a small voltage of 1.52 V at 10 mA cm^(-2) is achieved when FeNi-Nd_(2)O_(3)/NCN is assessed as bifunctional catalyst for overall water splitting,which is superior to the typically integrated Pt/C and RuO_(2) counterparts(1.54 V at 10 mA cm^(-2)).The related characterizations including X-ray absorption fine structure(XAFS)spectroscopy show that the remarkably improved activity is originated from Nd_(2)O_(3)-induced FeNi bimetallic lattice contraction.Furthermore,density functional theory(DFT) calculations indicate that the lattice contraction reduces binding energies of intermediates by downshifting the position of FeNi bimetallic d-band center relative to the Fermi level to optimize catalytic performance.Therefore,the Nd_(2)O_(3)-induced FeNi bimetallic lattice contraction may provide a new perspective for designing and synthesizing innovative catalytic systems. | Jiajia Li Yunong Qin Tianyu Tan Qiancheng Zhu Bo Ouyang Erjun Kan Wenming Zhang | 2023 | Journal of Energy Chemistry2023，，12： | 0 |
| 7 | Single-cell transcriptomics reveals cell type diversity of human prostate显示文摘Extensive studies have been performed to describe the phenotypic changes occurring during malignant transformation of the prostate.However,the cell types and associated changes that contribute to the development of prostate diseases and cancer remain elusive,largely due to the heterogeneous composition of prostatic tissues.Here,we conduct a comprehensive evaluation of four human prostate tissues by singlecell RNA sequencing(sc RNA-seq)to analyze their cellular compositions.We identify 18 clusters of cell types,each with distinct gene expression profiles and unique features;of these,one cluster of epithelial cells(Ep)is found to be associated with immune function.In addition,we characterize a special cluster of fibroblasts and aberrant signaling changes associated with prostate cancer(PCa).Moreover,we provide insights into the epithelial changes that occur during the cellular senescence and aging.These results expand our understanding of the unique functional associations between the diverse prostatic cell types and the contributions of specific cell clusters to the malignant transformation of prostate tissues and PCa development. | Yang Chen Peng Zhang Jinling Liao Jiwen Cheng Qin Zhang Tianyu Li Haiying Zhang Yonghua Jiang Fangxing Zhang Yanyu Zeng Linjian Mo Haibiao Yan Deyun Liu Qinyun Zhang Chunlin Zou Gong-Hong Wei Zengnan Mo | 2022 | Journal of Genetics and Genomics2022，49，11： | 0 |
| 8 | Crystal plane engineering of MAPbI_(3) in epoxy-based materials for superior gamma-ray shielding performance显示文摘The rapid development of the aerospace and nuclear industries is accompanied by increased exposure to high-energy ionising radiation.Thus,the performance of radiation shielding materials needs to be improved to extend the service life of detectors and ensure the safety of personnel.The development of novel lightweight materials with high electron density has therefore become urgent to alleviate radiation risks.In this work,new MAPbI_(3)/epoxy(CH 3NH 3PbI 3/epoxy)composites were prepared via a crystal plane engineering strategy.These composites delivered excellent radiation shielding performance against 59.5 keV gamma rays.A high linear attenuation coefficient(1.887 cm−1)and mass attenuation coefficient(1.352 cm2 g−1)were achieved for a representative MAPbI_(3)/epoxy composite,which was 10 times higher than that of the epoxy.Theoretical calculations indicate that the electron density of MAPbI_(3)/epoxy composites significantly increases when the content ratio of the(110)plane in MAPbI_(3) increases.As a result,the chances of collision between the incident gamma rays and electrons in the MAPbI_(3)/epoxy composites were enhanced.The present work provides a novel strategy for designing and developing high-efficiency radiation shielding materials. | Kai Cui Yang Li Wenjing Wei Qianqian Teng Tianyu Zhang Jinzhu Wu Hongjun Kang Wei Qin Xiaohong Wu | 2022 | Light(Advanced Manufacturing)2022，3，4： | 0 |
| 9 | Effects of Tiaomaiyin and Its Disassembled Prescription on Expression of L-type Calcium Channel β2 Subunit in Rat Model of Tachyarrhythmia显示文摘[Objectives] To study the effects of Tiaomaiyin and its disassembled prescription on expression of L-type calcium channel β2 subunit in rat model of tachyarrhythmia. [Methods] Sixty Wistar rats were randomly divided into model group,Tiaomaiyin prescription group( whole prescription group),main efficacy group of removing heat to cool blood( blood cooling group),and auxiliary drug efficacy group of benefiting qi and nourishing heart( qi benefiting group),auxiliary efficacy group of promoting flow of qi and blood circulation( qi flow promoting group),and amiodarone group( western medicine group). Aconitine was given 7 d after the intragastric administration of the corresponding drugs,and the time of occurrence of arrhythmia in each group was observed. The left ventricular myocardium was subjected to reverse transcription-polymerase chain reaction and Western blotting. [Results] The ventricular premature beats( VPB) time in the whole prescription group and western medicine group was significantly longer than that in the model group. Ventricular tachycardia( VT),ventricular fibrillation( VF),and cardiac arrest( CA) were longer in the whole prescription group,blood cooling group,and western medicine group. The mRNA and protein expression of L-type calcium channel β2 subunit in the whole prescription group,blood cooling group and western medicine group were significantly decreased. [Conclusions] Tiaomaiyin whole prescription group and blood cooling group can reduce the occurrence time of tachyarrhythmia and reduce the expression of LTCC β2 in myocardium. | Jingze SU Yao HAN Zhizhen WEI Wen SUN Tianyu QIN | 2019 | Medicinal Plant2019，10，3： | 0 |
| 10 | Characteristics and outcomes of patients with autoimmune pancreatitis after pancreatectomy:a retrospective study显示文摘Objective:Autoimmune pancreatitis(AIP)is a rare and special type of pancreatitis,which is often difficult to distinguish from pancreatic cancer.We aimed to discuss the clinical characteristics,operation characteristics,and therapeutic effects of AIP pa-tients who received surgical treatment based on retrospective analysis.Methods:The medical records of patients who underwent surgery at Peking Union Medical College Hospital from January 2012 to July 2021 and whose postoperative pathology was AIP were collected.Clinical symptoms,laboratory examinations,imaging features,surgical information,and prognostic data were analyzed.Results:Nineteen patients with AIP(median age 60 years old,14 males)underwent surgery,whose main indication for surgery was suspected of a malignant lesion(n=18,94.7%).Ten patients underwent pancreaticoduodenectomy,8 underwent distal pancreatectomy,and 1 underwent total pancreatectomy,the pathological result of whom were all AIP.The main postoperative complication was pancreatic fistula(n=11,57.9%),and one patient(5.3%)underwent a second operation due to gastrointestinal anastomotic bleeding.One patient(5.6%)had a recurrence of AIP,3 patients(16.7%)were treated with glucocorticoid after sur-gery,and one patient(5.6%)was treated with immunosuppressors.Conclusions:Differential diagnosis of AIP from pancreatic cancer is complex.Operation difficulty and complication incidence for patients with AIP were similar to pancreatic cancer patients.Although glucocorticoid is the first-line treatment for AIP,surgery may still be necessary for patients who are strongly suspected of a malignant lesion. | Bangbo Zhao Cheng Qin Tianyu Li Zeru Li Yuanyang Wang Weibin Wang | 2023 | Journal of Pancreatology2023，6，2： | 0 |
| 11 | Theoretical and experimental study of a bi-stable piezoelectric energy harvester under hybrid galloping and band-limited random excitations显示文摘In the practical environment,it is very common for the simultaneous occurrence of base excitation and crosswind.Scavenging the combined energy of vibration and wind with a single energy harvesting structure is fascinating.For this purpose,the effects of the wind speed and random excitation level are investigated with the stochastic averaging method(SAM)based on the energy envelope.The results of the analytical prediction are verified with the Monte-Carlo method(MCM).The numerical simulation shows that the introduction of wind can reduce the critical excitation level for triggering an inter-well jump and make a bi-stable energy harvester(BEH)realize the performance enhancement for a weak base excitation.However,as the strength of the wind increases to a particular level,the influence of the random base excitation on the dynamic responses is weakened,and the system exhibits a periodic galloping response.A comparison between a BEH and a linear energy harvester(LEH)indicates that the BEH demonstrates inferior performance for high-speed wind.Relevant experiments are conducted to investigate the validity of the theoretical prediction and numerical simulation.The experimental findings also show that strong random excitation is favorable for the BEH in the range of low wind speeds.However,as the speed of the incoming wind is up to a particular level,the disadvantage of the BEH becomes clear and evident. | Haitao LI Tianyu ZHENG Weiyang QIN Ruilan TIAN Hu DING J.C.JI Liqun CHEN | 2024 | Applied Mathematics and Mechanics(English Edition)2024，45，3： | 0 |
| 12 | Canopy structure:An intermediate factor regulating grassland diversity-function relationships under human disturbances显示文摘Grasslands are one of the largest coupled human-nature terrestrial ecosystems on Earth,and severe anthropogenic-induced grassland ecosystem function declines have been reported recently.Understanding factors influencing grassland ecosystem functions is critical for making sustainable management policies.Canopy structure is an important factor influencing plant growth through mediating within-canopy microclimate(e.g.,light,water,and wind),and it is found coordinating tightly with plant species diversity to influence forest ecosystem functions.However,the role of canopy structure in regulating grassland ecosystem functions along with plant species diversity has been rarely investigated.Here,we investigated this problem by collecting field data from 170 field plots distributed along an over 2000 km transect across the northern agro-pastoral ecotone of China.Aboveground net primary productivity(ANPP)and resilience,two indicators of grassland ecosystem functions,were measured from field data and satellite remote sensing data.Terrestrial laser scanning data were collected to measure canopy structure(represented by mean height and canopy cover).Our results showed that plant species diversity was positively correlated to canopy structural traits,and negatively correlated to human activity intensity.Canopy structure was a significant indicator for ANPP and resilience,but their correlations were inconsistent under different human activity intensity levels.Compared to plant species diversity,canopy structural traits were better indicators for grassland ecosystem functions,especially for ANPP.Through structure equation modeling analyses,we found that plant species diversity did not have a direct influence on ANPP under human disturbances.Instead,it had a strong indirect effect on ANPP by altering canopy structural traits.As to resilience,plant species diversity had both a direct positive contribution and an indirect contribution through mediating canopy cover.This study highlights that canopy structure is an important intermediate factor regulating grassland diversity-function relationships under human disturbances,which should be included in future grassland monitoring and management. | Xiaoxia Zhao Yuhao Feng Kexin Xu Mengqi Cao Shuya Hu Qiuli Yang Xiaoqiang Liu Qin Ma Tianyu Hu Maggi Kelly Qinghua Guo Yanjun Su | 2023 | Fundamental Research2023，3，2： | 0 |
| 13 | Synergistic effect of CuO coupled with MoS_(2) for enhanced photodegradation of organic dyes under visible light显示文摘A series of MoS_(2)-modified CuO(CuO/MoS_(2))heterostructures were successfully fabricated.The photodegradation properties of organic dyes were explored in detail under visible light.The photocatalytic results demonstrate that the CuO/MoS_(2)-3 heterostructure delivers superior degradation rates towards methyl violet dye(MV)and rhodamine B(RhB),reaching 99.8%and 95.3%within 30 min,respectively.The decent photodegradation activity is due to improved visible light adsorption and faster transfer of electron-hole pairs.The radical trapping experiments show that superoxide radicals(O_(2)^(-))and holes(h+)are the main active species in the removal of MV.Furthermore,the CuO/MoS_(2)-3 composite possesses the prominent stability and recyclability.This work offers a highly sustainable technique for designing a high-efficiency photocatalyst to remove environmental pollutants. | Umsalama Abuelgasim Abubakr Yasin Zhixin Jia Ziwen Qin Tianyu Guo Ruihua Zhao Jianping Du | 2023 | Chinese Journal of Chemical Engineering2023，64，12： | 0 |
| 14 | Exosome-mediated cell-cell communication within pancreatic cancer tumor microenvironment: a narrative review显示文摘The significance of exosomes has emerged in a variety of physiological processes and diseases.Pancreatic cancer remains one of the most lethal diseases at present.Recently,increasing evidence has suggested that exosomes are vital for mediating the elaborate interaction of highly heterogeneous cell clusters within the pancreatic tumor microenvironment,contributing to activating pancreatic stellate cells and cancer-associated fibroblasts,compromising immune cells,and enhancing angiogenesis.Besides their natural and intrinsic roles,exosomes may provide a novel potential way for pancreatic cancer management and therapy as well.Thus,exosomes not only mediate cellular communication during pancreatic cancer progression but also serve as a promising player in precise pancreatic cancer management and treatment.To comprehensively summarize the role of exosomes in pancreatic cancer,we searched the PubMed database and reviewed all relevant original studies. | Cheng Qin Bangbo Zhao Yuanyang Wang Tianhao Li Zeru Li Tianyu Li Yutong Zhao Weibin Wang | 2022 | Journal of Pancreatology2022，5，3： | 0 |
| 15 | Exosome-mediated cell-cell communication within pancreatic cancer tumor microenvironment:a narrative review显示文摘The significance of exosomes has emerged in a variety of physiological processes and diseases.Pancreatic cancer remains one of the most lethal diseases at present.Recently,increasing evidence has suggested that exosomes are vital for mediating the elaborate interaction of highly heterogeneous cell clusters within the pancreatic tumor microenvironment,contributing to activating pancreatic stellate cells and cancer-associated fibroblasts,compromising immune cells,and enhancing angiogenesis.Besides their natural and intrinsic roles,exosomes may provide a novel potential way for pancreatic cancer management and therapy as well.Thus,exosomes not only mediate cellular communication during pancreatic cancer progression but also serve as a promising player in precise pancreatic cancer management and treatment.To comprehensively summarize the role of exosomes in pancreatic cancer,we searched the PubMed database and reviewed all relevant original studies. | Cheng Qin Bangbo Zhao Yuanyang Wang Tianhao Li Zeru Li Tianyu Li Yutong Zhao Weibin Wang | 2023 | Journal of Pancreatology2023，6，1： | 0 |
| 16 | How high can fracture porosity become in the ultra-deep subsurface?显示文摘Knowledge of how high can fracture porosity become in the ultra-deep burial conditions is important but remains problematic.Fracture aperture and porosity are measured using X-ray computed tomography(CT)at atmospheric pressure and then calculated by image logs.Special attention is paid to how high fracture porosity can become in ultra-deep(>6000 m)settings,and which situations will result in high fracture porosities.In situ stress magnitudes,which can be calculated using well logs,control fracture performances,and dissolution along fracture improve fracture porosity at ultra-deep burial depths.Low horizontal stress difference(Dr<25 MPa),very high fracture density will result in a high fracture porosity.Fracture porosity can keep as high as 2.0%in relatively low in situ stress conditions even at ultra-deep burial depths.In intense in situ stress conditions(Dr>45 MPa),a high degree of dissolution along the fracture dramatically increases fracture porosity.Dissolution will result in the vuggy fracture planes and improve fracture porosity up to 2.0%.The results provide insights into the detection,characterization,and modeling of subsurface fractures. | Jin Lai Fei Zhao Mei Zhang Tianyu Bai Yuyue Huang Dong Li Guiwen Wang Ziqiang Qin | 2023 | Geoscience Frontiers2023，14，5： | 0 |
| 17 | Synthesis of sponge-like TiO_(2) with surface-phase junctions for enhanced visible-light photocatalytic performance显示文摘Maximizing adsorption and catalytic active sites and promoting the photo-excited charge separation are two key factors to achieve excellent photocatalytic performance.In this study,we report a sol-gel synthesis approach to obtain non-metal doped TiO_(2)with sponge-like structure and surface-phase junctions all at once.While doping of carbon and nitrogen shifted the activation wavelength to the visible-light region,the innovative use of perchloric acid as a pore-making agent led to the formation of three-dimensional lamellar and porous structure with surface-phase junctions.High surface area with catalytic active sites rendered by the sponge-like structure and surface-phase junctions contributed to the much improved photocatalytic degradation efficiency toward rhodamine B,tetracycline and Disperse Red 60 with excellent reusability and stability.The improved gen eration and separati on efficie ncy of the photo-induced charge carriers of the as-prepared TiO_(2)were supported by electrochemical impedance measurements and transient photocurrent responses.This method could also be applied to other photocatalysts to achieve structural alteration and element doping simultaneously. | Yue Jiang Yao Qin Tianyu Yu Sijie Lin | 2021 | Chinese Chemical Letters2021，32，5： | 0 |
| 18 | Rosuvastatin suppresses TNF-α-induced matrix catabolism,pyroptosis and senescence via the HMGB1/NF-κB signaling pathway in nucleus pulposus cells显示文摘Intervertebral disc degeneration is mainly caused by irregular matrix metabolism in nucleus pulposus cells and involves inflammatory factors such as TNF-α.Rosuvastatin,which is widely used in the clinic to reduce cholesterol levels,exerts anti-inflammatory effects,but whether rosuvastatin participates in IDD remains unclear.The current study aims to investigate the regulatory effect of rosuvastatin on IDD and the potential mechanism.In vitro experiments demonstrate that rosuvastatin promotes matrix anabolism and suppresses catabolism in response to TNF-αstimulation.In addition,rosuvastatin inhibits cell pyroptosis and senescence induced by TNF-α.These results demonstrate the therapeutic effect of rosuvastatin on IDD.We further find that HMGB1,a gene closely related to cholesterol metabolism and the inflammatory response,is upregulated in response to TNF-αstimulation.HMGB1 inhibition or knockdown successfully alleviates TNF-α-induced ECM degradation,senescence and pyroptosis.Subsequently,we find that HMGB1 is regulated by rosuvastatin and that its overexpression abrogates the protective effect of rosuvastatin.We then verify that the NF-κB pathway is the underlying pathway regulated by rosuvastatin and HMGB1.In vivo experiments also reveal that rosuvastatin inhibits IDD progression by alleviating pyroptosis and senescence and downregulating HMGB1 and p65.This study might provide new insight into therapeutic strategies for IDD. | Weijian Chen Zhihuai Deng Jianxiong Zhu Liang Yuan Shuangxing Li Yangyang Zhang Jiajun Wu Zhengqi Huang Tianyu Qin Wei Ye | 2023 | Acta Biochimica et Biophysica Sinica2023，55，5： | 0 |
| 19 | Discovery of the largest natural carbon onions on Earth显示文摘The synthesis of carbon onions in the laboratory by various methods is common;however, naturally occurring carbon onions have only been found in a few geological samples on Earth. This study used high-resolution transmission electron microscopy to identify natural carbon onions in seven intrusion-affected coal samples collected from Permian coal-bearing strata in the Yongan Coalfield, Fujian Province, South China. This study identified the largest natural carbon onions ever recorded on Earth;their outer diameter was ~55 nm. Granite porphyry intrusions and quartz hydrothermal veins are abundant in the Permian coal-bearing strata in this coalfield. All samples collected were tectonically deformed coals with highly developed structural fractures, friction mirror planes, and maximum vitrinite reflectance values of 4.0–9.5%. Natural carbon onions observed in the coal samples had single or multiple cores, with 24–46 graphitic shells characterized by outer diameters of 24–55 nm. The maximum vitrinite reflectance, outer diameter, and graphitic shell number of carbon onions in the intrusion-affected coal were positively correlated, indicating that the carbon onions were secondary products formed during coal metamorphism owing to magmatic intrusion. Our results suggest that carbon onions in intrusion-affected coal are synthesized by chemical vapor deposition. We speculate that natural carbon onions exist mainly in fractures or cavities, similar to vapor-deposited pyrolytic carbon, which is the leading cause of the uneven distribution of carbon onions in intrusion-affected coals in the study area. | Yilin CHEN Yong QIN Jiuqing LI Zhuangfu LI Tianyu YANG Ergang LIAN | 2022 | Science China Earth Sciences2022，65，9： | 0 |
| 20 | Recent advances in targeted therapy for ovarian cancer显示文摘The global burden of ovarian cancer is gradually increasing while patients still suffer from relatively limited treatment options.With recent advances in the decoding of the molecular landscape of ovarian cancer,more options in targeted strategy were offered and can therefore be tailored in different clinical settings for individual patient.Targeting of the abnormal angiogenesis process is the first significant clinical breakthrough which revolutionized the treatment of advanced ovarian cancer,followed by the advent of poly-(ADP)-ribose polymerase(PARP)inhibitors.These two strategies represented by bevacizumab and olaparib respectively underwent tests of numerous clinical trials.In recent years,immune checkpoint inhibitors(ICIs)have been incorporated into the blueprint of ovarian cancer treatment though the effectiveness still left much to be desired.Herein,we systematically outlined recent advances in targeted therapy for ovarian cancer and summarized the landmark clinical trials for each targeted therapy including angiogenesis inhibitors,PARP inhibitors and ICIs. | Tianyu Qin Gang Chen | 2022 | Oncology and Translational Medicine2022，8，1： | 0 |
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