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| 1 | High-speed image reconstruction for optically sectioned,super-resolution structured illumination microscopy显示文摘Super-resolution structured illumination microscopy(SR-SIM)is an outstanding method for visualizing the subcellular dynamics in living cells.To date,by using elaborately designed systems and algorithms,SR-SIM can achieve rapid,optically sectioned,SR observation with hundreds to thousands of time points.However,real-time observation is still out of reach for most SIM setups as conventional algorithms for image reconstruction involve a heavy computing burden.To address this limitation,an accelerated reconstruction algorithm was developed by implementing a simplified workflow for SR-SIM,termed joint space and frequency reconstruction.This algorithm results in an 80-fold improvement in reconstruction speed relative to the widely used Wiener-SIM.Critically,the increased processing speed does not come at the expense of spatial resolution or sectioning capability,as demonstrated by live imaging of microtubule dynamics and mitochondrial tubulation. | Zhaojun Wang Tianyu Zhao Huiwen Hao Yanan Cai Kun Feng Xue Yun Yansheng Liang Shaowei Wang Yujie Sun Piero RBianco Kwangsung Oh Ming Lei | 2022 | Advanced Photonics2022，4，2： | 9 |
| 2 | Geochemistry,Zircon U-Pb Age and Hf Isotopic Constraints on the Petrogenesis of the Silurian Rhyolites in the Loei Fold Belt and Their Tectonic Implications显示文摘Zircon U-Pb dating, Lu-Hf isotopic and geochemical data for the Silurian rhyolites from the Loei fold belt are presented to constrain their petrogenesis and tectonic settings. The rhyolites give a weighted mean ^(206)Pb/^(238) U age of 423.7±2.7 Ma, and are characterized by high SiO_2, Al_2O_3, K_2 O and low MnO, MgO and P_2O_5. All samples are enriched in LILEs(e.g., Ba, K, Pb) and LREEs and depleted in HFSEs(e.g., Nb, Ta, Ti) with obvious negative Eu-anomalies(δEu=0.56–0.63). The calc-alkaline rhyolites are typical arc-related rocks. The Loei rhyolites have high A/CNK ratios(1.19–1.34) and positive εHf(t)(4.03–5.38), which can be interpreted as partial melting of juvenile crustal materials followed by multistage melting and differentiation, similar to highly fractional I-type rocks. Combined with regional geological surveys, the Loei rhyolites should be formed in a volcanic arc environment and may be in contact with the Truong Son fold belt during the Early Paleozoic. Moreover, the Simao Block might be in contiguity with the Indochina Block during Silurian. | Tianyu Zhao Xin Qian Qinglai Feng | 2016 | Journal of Earth Science2016，27，3： | 6 |
| 3 | Hierarchically porous carbon foams for electric double layer capacitors显示文摘对便携式的电子设备的成长要求意味着力量采购的那个无足轻重的人逐渐地被寻求在以后。电的双层电容器(EDLC ) 正在答应候选人因为使用尽最大努力由于他们的高力量密度和突出的控告 / 解除骑车稳定性采购原料。三维(3D ) 自食其力基于碳的材料广泛地在小 EDLC 为使用被学习了。然而,为 3D 碳电极的主要挑战是在他们的内部空格的有限离子散开率。探讨这限制,为内部离子散开提供另外的隧道的层次地多孔的 3D 结构被建议了。此处,我们为 ultralight 的合成报导一个新化学方法(9.92 mg/cm 3) 3D 面对钾碳酸盐包含连接 glutaraldehydecross 的 chitosan aerogel 的碳化的多孔的碳泡沫(PCF ) 。电子显微镜学图象表明碳泡沫是包含一致地驱散的 macropores 的碳表的一个互连的网络。另外, Brunauer-Emmett-Teller 大小证实层次地多孔的结构。PCF 电极能完成的电气化学的数据表演当当前的密度从 0.5 ~ 100 A/g 被增加时,在 0.5 A/g 的当前的密度的 246.5 F/g 的一个突出的 gravimetric 电容,和 67.5% 的显著电容保留被观察。伪固态的对称的 supercapacitor 经由二的汇编被制作新 PCF 并且被发现交付一超离频在 2.8 Wh/kg 的精力密度的 25 kW/kg 的力量密度。这研究与高电容的性能表明 ultralight 和层次地多孔的碳泡沫的合成。 | Feng Zhan Tianyu Liu Guihua Hou Tianyi Kou Lu Yue Rongfeng Guan Yat Li | 2016 | Nano Research2016，9，10： | 5 |
| 4 | Proto-Tethys ophiolitic mélange in SW Yunnan: Constraints from zircon U-Pb geochronology and geochemistry显示文摘An early Paleozoic Proto-Tethys ocean in western Yunnan has long been postulated although no robust geological evidence has been identified.Here we investigated the recently-identified Mayidui and Wanhe ophiolitic mélanges in SW Yunnan,which occurs in a N-S trending belt east of the late Paleozoic Changning-Menglian suture zone.The ophiolites consist mainly of meta-basalts(amphibole schists),meta-(cumulate)gabbros and gabbroic diorites,and meta-chert-shale,representing ancient oceanic crust and pelagic and hemipelagic sediments,respectively.Six samples of gabbros and gabbroic diorites from 3 profiles(Mayidui,Kongjiao and Yinchanghe)yielded zircon U-Pb ages between 462±6 Ma and 447±9 Ma,constraining the formation of the Mayidui and Wanhe ophiolites to Middle Ordovician.Gabbros from the Mayidui and Kongjiao profiles share similar geochemical characteristics with affinities to tholeiitic series,and are characterized by depleted to slightly enriched LREEs relative to HREEs with(La/Sm)N=0.69-1.87,(La/Yb)N=0.66-4.72.These,along with their predominantly positive wholerock eNd(t)and zircon eHf(t)values,indicate a MORB-like magma source.By contrast,the meta-mafic rocks from the Yinchanghe profile show significantly enriched LREEs((La/Sm)N=0.97-3.33,(La/Yb)N=1.19-14.93),as well as positive whole-rock eNd(t)and positive to negative zircon eHf(t)values,indicating an E-MORB-type mantle source.These geochemical features are consistent with an intra-oceanic setting for the formation of the Mayidui-Wanhe ophiolites.Our data,integrated with available geological evidence,provide robust constraints on the timing and nature of the Mayidui-Wanhe ophiolitic mélange,and suggest that the ophiolites represent remnants of the Proto-Tethys Ocean,which opened through separation of the Indochina and Simao blocks from the northern margin of Gondwana before the Early Cambrian,and evolved through to the Silurian. | Guichun Liu Zaibo Sun Jianwei Zi M.Santosh Tianyu Zhao Qinglai Feng Guangyan Chen Xiaomei Nie Jing Li Shitao Zhang | 2021 | Geoscience Frontiers2021，12，5： | 5 |
| 5 | In-situ/operando techniques to identify active sites for thermochemical conversion of CO_(2) over heterogeneous catalysts显示文摘The catalytic conversion of CO_(2) to fuels or chemicals is considered to be an effective pathway to mitigate the greenhouse effect. To develop new types of efficient and durable catalysts, it is critical to identify the catalytic active sites, surface intermediates, and reaction mechanisms to reveal the relationship between the active sites and catalytic performance. However, the structure of a heterogeneous catalyst usually dynamically changes during reaction, bringing a great challenge for the identification of catalytic active sites and reaction pathways. Therefore, in-situ/operando techniques have been employed to real-time monitor the dynamic evolution of the structure of active sites under actual reaction conditions to precisely build the structure–function relationship. Here, we review the recent progress in the application of various in-situ/operando techniques in identifying active sites for catalytic conversion of CO_(2) over heterogeneous catalysts. We systematically summarize the applications of various optical and X-ray spectroscopy techniques, including Raman spectroscopy, Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and X-ray absorption spectroscopy (XAS), in identifying active sites and determining reaction mechanisms of the CO_(2) thermochemical conversion with hydrogen and light alkanes over heterogeneous catalysts. Finally, we discuss challenges and opportunities for the development of in-situ characterization in the future to further enlarge the capability of these powerful techniques. | Kai Feng Yaning Wang Man Guo Jingpeng Zhang Zhengwen Li Tianyu Deng Zhihe Zhang Binhang Yan | 2021 | Journal of Energy Chemistry2021，30，11： | 5 |
| 6 | LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells显示文摘LIN28 is an RNA binding protein with important roles in early embryo development,stem cell differentiation/re-programming,tumorigenesis and metabolism.Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs,and few have addressed LIN28's role within the nucleus.Here,we show that LIN28 displays dynamic temporal and spatial expression during murine embryo development.Maternal LIN28 expression drops upon exit from the 2-cell stage,and zygotic LIN28 protein is induced at the forming nucleolus during 4-cell to blas-tocyst stage development,to become dominantly expressed in the cytosol after implantation.In cultured pluripotent stem cells(PSCs),loss of LIN28 led to nucleolar stress and activation of a 2-cell/4-cell-like transcriptional program characterized by the expression of endogenous retrovirus genes.Mechanistically,LIN28 binds to small nucleolar RNAs and rRNA to maintain nucleolar integrity,and its loss leads to nucleolar phase separation defects,ribosomal stress and activation of P53 which in turn binds to and activates 2C transcription factor Dux.LIN28 also resides in a complex containing the nucleolar factor Nucleolin(NCL)and the transcrip-tional repressor TRIM28,and LIN28 loss leads to reduced occupancy of the NCL/TRIM28 complex on the Dux and rDNA loci,and thus de-repressed Dux and reduced rRNA expression.Lin28 knockout cells with nucleolar stress are more likely to assume a slowly cycling,translationally inert and anabolically inactive state,which is a part of previously unappreciated 2C-like transcriptional program.These findings elucidate novel roles for nucleolar LIN28 in PSCs,and a new mechanism linking 2C program and nucleolar functions in PSCs and early embryo development. | Zhen Sun Hua Yu Jing Zhao Tianyu Tan Hongru Pan Yuqing Zhu Lang Chen Cheng Zhang Li Zhang Anhua Lei Yuyan Xu Xianju Bi Xin Huang Bo Gao Longfei Wang Cristina Correia Ming Chen Qiming Sun Yu Feng Li Shen Hao Wu Jianlong Wang Xiaohua Shen George Q.Daley Hu Li Jin Zhang | 2022 | Protein & Cell2022，13，7： | 4 |
| 7 | Monitoring the Amery Ice Shelf front during 2004-2012 using ENVISAT ASAR data显示文摘The Amery Ice Shelf is the largest ice shelf in East Antarctica. It drains continental ice from an area of more than one million square kilometres through a section of coastline that represents approximately 2% of the total circumference of the Antarctic continent. In this study, we used a time series of ENVISAT ASAR images from 2004-2012 and flow lines derived from surface velocity data to monitor the changes in 12 tributaries of the Amery Ice Shelf front. The results show that the Amery Ice Shelf has been expanding and that the rates of expansion differ across the shelf. The highest average annual rate of advance from 2004-2012 was 3.36 m·d-1 and the lowest rate was 1.65 m·d-1 . The rates in 2009 and 2010 were generally lower than those in other years. There was a low correlation between the rate of expansion and the atmospheric temperature recorded at a nearby research station, however the mechanism of the relationship was complex. This study shows that the expansion of the Amery Ice Shelf is slowing down, reflecting a changing trend in climate and ice conditions in East Antarctica. | ZHAO Chen CHENG Xiao HUI Fengming KANG Jing LIU Yan WANG Xianwei WANG Fang CHENG Cheng FENG Zhunzhun CI Tianyu ZHAO Tiancheng ZHAI Mengxi | 2013 | Advances in Polar Science2013，24，2： | 4 |
| 8 | The protective roles of tea tree oil extracts in bovine mammary epithelial cells and polymorphonuclear leukocytes显示文摘Background: Tea tree oil(TTO) plays an important role in antibacterial activity and alleviating the inflammatory responses. Bovine mammary epithelium and polymorphonuclear leukocytes(PMNL) can actively respond to bovine mastitis infection. However, regulatory effects of TTO extracts on the innate immune response of bovine mammary epithelial cells(BMECs) and PMNL remain not reported. Therefore, aim of the study was to evaluate the effects of TTO extracts on the m RNA levels of the genes involved in the innate immune response of BMECs and PMNL.Results: Our results demonstrated that addition of 0.025% and 0.05% TTO increased the proliferation of BMECs, and significantly enhanced(P < 0.05) the viability of BMECs exposed to Staphylococcus aureus(S. aureus). An inhibitory effect was observed against the growth of S. aureus by TTO incubation. The 0.05% TTO reduced S. aureus biofilm formation, association and invasion of S. aureus to BMECs, and changed the morphological and structural features of S. aureus. The proinflammatory cytokines IL-1β, IL-6, and TNF-α were decreased(P < 0.001) by the incubation of TTO. Interestingly, the expression of IL-8 known for PMNL chemotactic function was elevated(P < 0.05) by 0.05%TTO treatment. Consistently, 0.05% TTO increased the migration of PMNL in S. aureus-exposed BMECs when compared with S. aureus treatment alone(P < 0.05). In addition, PMNL incubated with 0.05% TTO decreased the levels of NFKB inhibitor alpha(NFKBIA) and TNF-α.Conclusions: Our results indicate that use of TTO can relieve the BMECs pro-inflammatory response caused by S.aureus and promote the migration of PMNL to mount the innate immune responses, and it may be novel strategy for the treatment of bovine mastitis caused by S. aureus. | Kang Zhan Tianyu Yang Baobao Feng Xinyu Zhu Yinyin Chen Yongjiu Huo Guoqi Zhao | 2020 | Journal of Animal Science and Biotechnology2020，11，4： | 3 |
| 9 | Enhanced damping capacity of ferromagnetic Fe-Ga alloys by introducing structural defects显示文摘The irreversible motion of magnetic domain walls in ferromagnets can dissipate a large portion of the elastic energy,and the associated damping capacity is proportional to the magnetostriction constant.In contrast,here we found that the damping capacity of the large magnetostriction Fe-Ga alloys can be enhanced by 2-3 times through introducing structural defects including interfacial dislocations and stacking faults,despite that these defects deteriorate the magnetostriction.These structural defects were introduced by aging the BCC(body-centered-cubic)solution-treated precursor,for which the formation of mechanically harder FCT(face-centered-tetragonal)and/or FCC(face-centered-cubic)phases can result in high-density partial dislocations at the semi-coherent phase interfaces and quasi-periodically stacked nano-layer substructure inside the FCC variants.The structural defects act as extra damping sources besides the magnetic domain walls because the structural accommodation of the semi-coherent phase interfaces between BCC and FCT/FCC nanoprecipitates with different elastic moduli and the nano-layer substructure towards long-range ordered periodical stacking can dissipate a large portion of mechanical energy.These findings suggest that introducing structural defects provides fresh freedom to design high damping ferromagnetic materials. | Ruihua Qiao Junming Gou Tianzi Yang Yiqun Zhang Feng Liu Shanshan Hu Tianyu Ma | 2021 | Journal of Materials Science & Technology2021，，25： | 3 |
| 10 | Geochronological and Geochemical Constraints on the Petrogenesis of Early Paleoproterozoic(2.40–2.32 Ga) Nb-Enriched Mafic Rocks in Southwestern Yangtze Block and Its Tectonic Implications显示文摘Recent geological survey has identified the Early Paleoproterozoic meta-mafic intrusions in the southwestern Yangtze Block.We present geochronological,whole-rock geochemical and Nd isotopic data for these meta-mafic rocks to better address the tectonic evolution of the Yangtze Block during the Early Paleoproterozoic Period.Geochronological data show that the meta-mafic rocks have zircon ages of 2 395-2 316 Ma.They have high TiO_2 contents of 1.40 wt.%-3.66 wt.% and Nb concentrations of 13.7 ppm-45.5 ppm,thus aregrouped as Nb-enriched mafic rocks.These mafic rocks are characterized by tholeiitic compositions with enrichment of LREEs and LILEs,and can be divided into two groups.Group 1 samples display E-MORB-like geochemical characteristics.Group 2 samples have positive ENd(t) values of 4.0-5.0.Geochemical data indicate that all meta-mafic rocks were likely derived from a depleted asthenospheric mantle.REE modeling indicates lower degree of partial melting for Group 2 samples(3%-10%) relative to Group 1 samples(15%-20%).Taking into account contemporaneous post-collisional granitoids in southwestern Yangtze Block,we propose that these meta-mafic rocks were formed in a post-collisional extension setting.These meta-mafic rocks can be compared with those in Africa,South America and Europe,and might be linked with the Arrowsmith orogenic belt. | Guichun Liu Xin Qian Jing Li Jian-Wei Zi Tianyu Zhao Qinglai Feng Guangyan Chen Shaobin Hu | 2020 | Journal of Earth Science2020，31，1： | 3 |
| 11 | Therapeutic strategies of glioblastoma (GBM):The current advances in the molecular targets and bioactive small molecule compounds显示文摘Glioblastoma(GBM)is the most common aggressive malignant tumor in brain neuroepithelial tumors and remains incurable.A variety of treatment options are currently being explored to improve patient survival,including small molecule inhibitors,viral therapies,cancer vaccines,and monoclonal antibodies.Among them,the unique advantages of small molecule inhibitors have made them a focus of attention in the drug discovery of glioblastoma.Currently,the most used chemotherapeutic agents are small molecule inhibitors that target key dysregulated signaling pathways in glioblastoma,including receptor tyrosine kinase,PI3K/AKT/mTOR pathway,DNA damage response,TP53 and cell cycle inhibitors.This review analyzes the therapeutic benefit and clinical development of novel small molecule inhibitors discovered as promising anti-glioblastoma agents by the related targets of these major pathways.Meanwhile,the recent advances in temozolomide resistance and drug combination are also reviewed.In the last part,due to the constant clinical failure of targeted therapies,this paper reviewed the research progress of other therapeutic methods for glioblastoma,to provide patients and readers with a more comprehensive understanding of the treatment landscape of glioblastoma. | Hui Liu Weimin Qiu Tianyu Sun Lei Wang Chenxi Du Yanyu Hu Wenyuan Liu Feng Feng Yao Chen Haopeng Sun | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 3 |
| 12 | Anti-aging effects of chlorpropamide depend on mitochondrial complex-Ⅱ and the production of mitochondrial reactive oxygen species显示文摘Sulfonylureas are widely used oral anti-diabetic drugs.However,its long-term usage effects on patients’lifespan remain controversial,with no reports of influence on animal longevity.Hence,the anti-aging effects of chlorpropamide along with glimepiride,glibenclamide,and tolbutamide were studied with special emphasis on the interaction of chlorpropamide with mitochondrial ATP-sensitive K+(mito K-ATP)channels and mitochondrial complex II.Chlorpropamide delayed aging in Caenorhabditis elegans,human lung fibroblast MRC-5 cells and reduced doxorubicin-induced senescence in both MRC-5 cells and mice.In addition,the mitochondrial membrane potential and ATP levels were significantly increased in chlorpropamide-treated worms,which is consistent with the function of its reported targets,mito K-ATP channels.Increased levels of mitochondrial reactive oxygen species(mt ROS)were observed in chlorpropamide-treated worms.Moreover,the lifespan extension by chlorpropamide required complex II and increased mt ROS levels,indicating that chlorpropamide acts on complex II directly or indirectly via mito K-ATP to increase the production of mt ROS as a pro-longevity signal.This study provides mechanistic insight into the anti-aging effects of sulfonylureas in C.elegans. | Zhifan Mao Wenwen Liu Yunyuan Huang Tianyue Sun Keting Bao Jiali Feng Alexey Moskalev Zelan Hu Jian Li | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 2 |
| 13 | Generation of isogenic single and multiplex gene knockout mice by base editing-induced STOP显示文摘Although CRISPR/Cas9 has been widely used to generate knockout mice, two major limitations remain:the founders usually carry a mixture of genotypes, and mosaicism harboring multiple genotypes.Therefore, it takes a long time to get homozygous mutants. Recently developed base editing(BE) system,which introduces C-to-T conversion without double strand DNA cleavage, has been used to introduce artificial stop codons(i-STOP) to prematurely terminate translation, providing a cleaner strategy for genome engineering. Using this strategy, we generated CD160 KO and VISTA/CD160 double KO mice by microinjection of a single sg RNA targeting CD160 and a mixture of sg RNAs targeting VISTA and CD160,respectively. The BE system induced STOP efficiently in mouse embryos and consequently in founder mice without detectable off-target. Most interestingly, the majority of the mutants harbor same genetic modifications, indicating we generated isogenic single and multiplex gene mutant mice by BE-induced STOP. We also obtained homozygous mutant mouse in F1 mice, demonstrating the accelerated strategy in generating animal models. | Guang Yang Tianyu Zhu Zongyang Lu Guanglei Li Hao Zhang Songjie Feng Yajing Liu Jianan Li Yu Zhang Jia Chen Xuejiang Guo Xingxu Huang | 2018 | Science Bulletin2018，63，17： | 2 |
| 14 | Tethyan evolution from early Paleozoic to early Mesozoic in southwest Yunnan显示文摘The Tethys orogenic belt in SW Yunnan constitutes a critical part of the expansive Tethys-Himalayan tectonic domain.The abundant,well-preserved geologic records make it an ideal area for studying the tectonic evolution of Proto-and Paleo-Tethys.In this paper,we focus on several major tectonic units in SW Yunnan and reconstruct the Tethyan evolution from the early Paleozoic to the early Mesozoic,based on stratigraphic,sedimentologic,and magmatic evidences.The recently discovered early Paleozoic Yunxian-Menghai ophiolitic belt in the Lincang Terrane situated east of the Changning-Menglian Belt represents the suture zone of the Proto-Tethys.The oceanic basin of Proto-Tehtys opened in the latest Neoproterozoic and subsequently began subducting in the late Miaolingian of the Cambrian(about 505 Ma).From the late Late Ordovician to the ealiest Silurian(about 450–442 Ma),the Proto-Tethys basin gradually closed resulting in the collision of the continental plates on both sides of the Proto-Tethyan ocean.The main collision stage occurred in the early Silurian(about 442–430 Ma)and the postcollision stage lasted from the mid-Silurian to the early Carboniferous(430–355 Ma).The earliest record of Paleo-Tethyan oceanic crust was generated in the late Devonian,and the ocean was then subducted in an eastward direction in the middle Late Carboniferous(about 310 Ma).The initial collision stage in the Paleo-Tethys took place at the end of the Permian(about 253Ma),and the main stage of the collision persisted into the early Ladinian(about 253–238 Ma).This was followed by postcollision extension from the late Ladinian to the early Jurassic(ca.238–196 Ma).We suggest that the opening of Paleo-Tethyan Ocean in SW Yunnan was a result of the extensional rift basin of the Proto-Tethys.Additionally,the activity of the Manxin mantle plume was likely a crucial factor in the rapid expansion of the Paleo-Tethyan Ocean. | Qinglai FENG Guichun LIU Zhengqin GAN Tianyu ZHAO Jianwei ZI Yuehua WEI | 2023 | Science China Earth Sciences2023，66，12： | 1 |
| 15 | Photophysics, morphology and device performances correlation on non-fullerene acceptor based binary and ternary solar cells显示文摘Non-fullerene acceptor(NFA) based organic solar cells(OSCs) are of high efficiency and low energy loss and low recombination features, which is owing to the advantage of non-fullerene acceptors. The photophysics investigation of non-fullerene solar cells, in comparing to fullerene based analogue as well as mixed acceptor ternary blends could help to understand the working mechanism of NFA functioning mechanism. We choose PBDB-T donor, the fullerene derivative PC71 BM acceptor, and the non-fullerene acceptor ITIC as the model system, to construct binary and ternary solar cells, which then subject to ultrafast spectroscopy investigation. The charge transfer pathway in binary and ternary blends is revealed.And it is seen that ITIC leads to a faster exciton separation and exciton diffusion. ITIC in blends suppresses the geminate recombination and shows smaller amount of charge transfer states, which is beneficial for the device performance. And the addition of ITIC enhances the crystallinity for both donor and acceptor leads to a morphology change of forming bicontinuous crystalline networks and phase separation. In a consequence, fill factor and JSC, increase dramatically for the related OSC. | Guanqing Zhou Hong Ding Lei Zhu Chaoqun Qiu Ming Zhang Tianyu Hao Wei Feng Yongming Zhang Haiming Zhu Feng Liu | 2020 | Journal of Energy Chemistry2020，29，8： | 1 |
| 16 | Population genomic analysis reveals domestication of cultivated rye from weedy rye显示文摘Rye(Secale cereale)is an important crop with multiple uses and a valuable genetic resource for wheat breeding.However,due to its complex genome and outcrossing nature,the origin of cultivated rye remains elusive.The geneticist N.I.Vavilov proposed that cultivated rye had been domesticated from weedy rye,rather than directly from wild species like other crops.Unraveling the domestication history of rye will extend our understanding of crop evolution and upend our inherent understanding of agricultural weeds.To this end,in this study we generated the 8.5 Tb of whole-genome resequencing data from 116 worldwide accessions of wild,weedy,and cultivated rye,and demonstrated that cultivated rye was domesticated directly from weedy relatives with a similar but enhanced genomic selection by humans.We found that a repertoire of genes that experienced artificial selection is associated with important agronomic traits,including shattering,grain yield,and disease resistance.Furthermore,we identified a composite introgression in cultivated rye from the wild perennial Secale strictum and detected a 2-Mb introgressed fragment containing a candidate ammonium transporter gene with potential effect on the grain yield and plant growth of rye.Taken together,our findings unravel the domestication history of cultivated rye,suggest that interspecific introgression serves as one of the likely causes of obscure species taxonomy of the genus Secale,and provide an important resource for future rye and wheat breeding. | Yanqing Sun Enhui Shen Yiyu Hu Dongya Wu Yu Feng Sangting Lao Chenfeng Dong Tianyu Du Wei Hua Chu-Yu Ye Jinhuan Zhu Qian-Hao Zhu Daguang Cai Lidia Skuza Jie Qiu Longjiang Fan | 2022 | Molecular Plant2022，15，3： | 1 |
| 17 | Graded index fiber as an all-fiber saturable absorber for large energy conventional soliton and dissipative soliton generation显示文摘In this work, we investigate the possibility of achieving nanojoule level pulse energy in an all-fiber Er-doped oscillator by using a graded index multimode fiber(GIMF) as the saturable absorber(SA). This GIMF-based SA demonstrates the desirable characteristics of high-power tolerance, large modulation depth of 29.6%, and small saturation fluence of7.19 × 10^-3μJ∕cm^2, which contribute to the high-energy soliton generation. In the experiments, the oscillator generates stable ultrafast pulse trains with high pulse energy/average output power up to 13.65 nJ/212.4 m W in the anomalous regime and 6.25 nJ/72.5 m W in the normal regime, which are among the highest energy/average output power values achieved by all-fiber Er lasers. The results obtained demonstrate that the GIMF-based SA can be used as an effective photonic device for high-energy wave-breaking free pulse generation. | ZHAOKUN WANG JIKAI CHEN TIANYU ZHU D.N.WANG FENG GAO | 2019 | Photonics Research2019，7，11： | 1 |
| 18 | DDX39B drives colorectal cancer progression by promoting the stability and nuclear translocation of PKM2显示文摘Metastasis is a major cause of colorectal cancer(CRC)mortality,but its molecular mechanisms are still not fully understood.Here,we show that upregulated DDX39B correlates with liver metastases and aggressive phenotypes in CRC.DDX39B is an independent prognostic factor associated with poor clinical outcome in CRC patients.We demonstrate that Sp1 potently activates DDX39B transcription by directly binding to the GC box of the DDX39B promoter in CRC cells.DDX39B overexpression augments the proliferation,migration,and invasion of CRC cells,while the opposite results are obtained in DDX39B-deficient CRC cells.Mechanistically,DDX39B interacts directly with and stabilizes PKM2 by competitively suppressing STUB1-mediated PKM2 ubiquitination and degradation.Importantly,DDX39B recruits importin a5 to accelerate the nuclear translocation of PKM2 independent of ERK1/2-mediated phosphorylation of PKM2,leading to the transactivation of oncogenes and glycolysis-related genes.Consequently,DDX39B enhances glucose uptake and lactate production to activate Warburg effect in CRC.We identify that Arg319 of DDX39B is required for PKM2 binding as well as PKM2 nuclear accumulation and for DDX39B to promote CRC growth and metastasis.In addition,blocking PKM2 nuclear translocation or treatment with glycolytic inhibitor 2-deoxy-D-glucose efficiently abolishes DDX39B-triggered malignant development in CRC.Taken together,ourfindings uncover akey role forDDX39B in modulating glycolytic reprogramming and aggressive progression,and implicate DDX39B as a potential therapeutic target in CRC. | Gang Zhao Hang Yuan Qin Li Jie Zhang Yafei Guo Tianyu Feng Rui Gu Deqiong Ou Siqi Li Kai Li Ping Lin | 2022 | Signal Transduction and Targeted Therapy2022，7，9： | 1 |
| 19 | Personal glucose meters coupled with signal amplification technologies for quantitative detection of non-glucose targets:Recent progress and challenges in food safety hazards analysis显示文摘Ensuring food safety is paramount worldwide.Developing effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix effects of food.Personal glucose meter(PGM),a classic point-of-care testing device,possesses unique application advantages,demonstrating promise in food safety.Currently,many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food hazards.Signal amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors,which is crucial for solving the challenges associated with the use of PGMs for food safety analysis.This review introduces the basic detection principle of a PGM-based sensing strategy,which consists of three key factors:target recognition,signal transduction,and signal output.Representative studies of existing PGM-based sensing strategies combined with various signal amplification technologies(nanomaterial-loaded multienzyme labeling,nucleic acid reaction,DNAzyme catalysis,responsive nanomaterial encapsulation,and others)in the field of food safety detection are reviewed.Future perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are discussed.Despite the need for complex sample preparation and the lack of standardization in the field,using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis. | Feng He Haijie Wang Pengfei Du Tengfei Li Weiting Wang Tianyu Tan Yaobo Liu Yanli Ma Yuanshang Wang A.M.Abd El-Aty | 2023 | Journal of Pharmaceutical Analysis2023，13，3： | 0 |
| 20 | 组蛋白H3泛素化通过影响H3K9甲基化进而调控肝脏发育相关基因表达的机制显示文摘文章简介肝脏的发育是一个多步骤并且受到严格调控的过程。过去的研究主要集中在个体出生前肝细胞如何分裂分化,并且多以转录因子和信号通路为研究对象。相比之下,肝脏在个体出生后直至成熟的过程中,虽然肝脏的发育并未停止,但是研究资料相对匮乏。 | Gaofeng Li Tong Ji Jiang Chen Yufei Fu Lidan Hou Yan Feng Tingyue Zhang Tianyu Song Jie Zhao Yoko Endo Hui Lin 蔡秀军 仓勇 | 2018 | 科学新闻2018，0，4： | 0 |
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