|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bolt-grouting combined support technology in deep soft rock roadway显示文摘Analyzing the mineral composition, mechanical properties and ground stress testing in surrounding rock,the study investigated the failure mechanism of deep soft rock roadway with high stress. The boltgrouting combined support system was proposed to prevent such failures. By means of FLAC3D numerical simulation and similar material simulation, the feasibility of the support design and the effectiveness of support parameters were discussed. According to the monitoring the surface and deep displacement in surrounding rock as well as bolt axial load, this paper analyzed the deformation of surrounding rock and the stress condition of the support structure. The monitor results were used to optimize the proposed support scheme. The results of field monitors demonstrate that the bolt-grouting combined support technology could improve the surround rock strength and bearing capacity of support structure, which controlled the great deformation failure and rheological property effectively in deep soft rock roadway with high stress. As a result, the long term stability and safety are guaranteed. | Chen Yanlong Meng Qingbin Xu Guang Wu Haoshuai Zhang Guimin | 2016 | International Journal of Mining Science and Technology2016，26，5： | 10 |
| 2 | Chinese herbal medicine reduces mortality in patients with severe and critical coronavirus disease 2019: a retrospective cohort study显示文摘This study aimed to evaluate the efficacy of Chinese herbal medicine(CHM)in patients with severe/critical coronavirus disease 2019(COVID-19).In this retrospective study,data were collected from 662 patients with severe/critical COVID-19 who were admitted to a designated hospital to treat patients with severe COVID-19 in Wuhan before March 20,2020.All patients were divided into an exposed group(CHM users)and a control group(non-users).After propensity score matching in a 1:1 ratio,156 CHM users were matched by propensity score to 156 non-users.No significant differences in seven baseline clinical variables were found between the two groups of patients.All-cause mortality was reported in 13 CHM users who died and 36 non-users who died.After multivariate adjustment,the mortality risk of CHM users was reduced by 82.2%(odds ratio 0.178,95%CI 0.076–0.418;P<0.001)compared with the non-users.Secondly,age(odds ratio 1.053,95%CI 1.023–1.084;P<0.001)and the proportion of severe/critical patients(odds ratio 0.063,95%CI 0.028–0.143;P<0.001)were the risk factors of mortality.These results show that the use of CHM may reduce the mortality of patients with severe/critical COVID-19. | Guohua Chen Wen Su Jiayao Yang Dan Luo Ping Xia Wen Jia Xiuyang Li Chuan Wang Suping Lang Qingbin Meng Ying Zhang Yuhe Ke An Fan Shuo Yang Yujiao Zheng Xuepeng Fan Jie Qiao Fengmei Lian Li Wei Xiaolin Tong | 2020 | Frontiers of Medicine2020，14，6： | 10 |
| 3 | Trehalose-6-phosphate phosphatase E modulates ABA-controlled root growth and stomatal movement in Arabidopsis显示文摘Trehalose plays important roles in plant growth and stress responses and is synthesized from trehalose-6-phosphate by trehalose-6-phosphate phosphatase(TPP).Here,we show that trehalose and abscisic acid(ABA)have synergistic effects on root growth and stomatal closure.The Arabidopsis thaliana genome contains ten genes encoding TPPs and the expression level of one,TPPE,and trehalose contents increased in response to ABA.In the pres-ence of ABA,the ABA-responsive transcription factor ABA RESPONSE ELEMENT BINDING FACTOR2(ABF2)directly binds to the TPPE promoter to activate its expression.Genetic analysis revealed that TPPE acts downstream of ABF2,which is supported by the findings that TPPE expression and trehalose content are reduced in the abf2 mutant and that a mutation in TPPE abolished the ABA-sensitive root elongation phenotype of 35S:ABF2 plants.Reactive oxygen spe-cies(ROS)accumulation in response to ABA failed to occur in tppe mutant plants,suggesting that TPPE is involved in ABA-controlled root elongation and sto-matal movement by inducing ROS accumulation.This study uncovers a new branch of the ABA signaling pathway and provides a molecular basis for the role of trehalose in plant responses to abiotic stress. | Wenjing Wang Qingbin Chen Shouming Xu Wen-Cheng Liu Xiaohong Zhu Chun-Peng Song | 2020 | Journal of Integrative Plant Biology2020，62，10： | 6 |
| 4 | Influence of dynamic pressure on deep underground soft rock roadway support and its application显示文摘Due to high ground stress and mining disturbance, the deformation and failure of deep soft rock roadway is serious, and invalidation of the anchor net-anchor cable supporting structure occurs. The failure characteristics of roadways revealed with the help of the ground pressure monitoring. Theoretical analysis was adopted to analyze the influence of mining disturbance on stress distribution in surrounding rock,and the change of stress was also calculated. Considering the change of stress in surrounding rock of bottom extraction roadway, the displacement, plastic zone and distribution law of principal stress difference under different support schemes were studied by means of FLAC3D. The supporting scheme of U-shaped steel was proposed for bottom extraction roadway that underwent mining disturbance. We carried out a similarity model test to verify the effect of support in dynamic pressure. Monitoring results demonstrated the change rules of deformation and stress of surrounding rock in different supporting schemes. The supporting scheme of U-shaped steel had an effective control on deformation of surrounding rock. The scheme was successfully applied in underground engineering practice, and achieved good technical and economic benefits. | Meng Qingbin Han Lijun Chen Yanlong Fan Jiadong Wen Shengyong Yu Liyuan Li Hao | 2016 | International Journal of Mining Science and Technology2016，26，5： | 4 |
| 5 | Anisotropic,Wrinkled,and Crack-Bridging Structure for Ultrasensitive,Highly Selective Multidirectional Strain Sensors显示文摘Flexible multidirectional strain sensors are crucial to accurately determining the complex strain states involved in emerging sensing applications.Although considerable efforts have been made to construct anisotropic structures for improved selective sensing capabilities,existing anisotropic sensors suffer from a trade-off between high sensitivity and high stretchability with acceptable linearity.Here,an ultrasensitive,highly selective multidirectional sensor is developed by rational design of functionally different anisotropic layers.The bilayer sensor consists of an aligned carbon nanotube(CNT)array assembled on top of a periodically wrinkled and cracked CNT-graphene oxide film.The transversely aligned CNT layer bridge the underlying longitudinal microcracks to effectively discourage their propagation even when highly stretched,leading to superior sensitivity with a gauge factor of 287.6 across a broad linear working range of up to 100%strain.The wrinkles generated through a pre-straining/releasing routine in the direction transverse to CNT alignment is responsible for exceptional selectivity of 6.3,to the benefit of accurate detection of loading directions by the multidirectional sensor.This work proposes a unique approach to leveraging the inherent merits of two cross-influential anisotropic structures to resolve the trade-off among sensitivity,selectivity,and stretchability,demonstrating promising applications in full-range,multi-axis human motion detection for wearable electronics and smart robotics. | Heng Zhang Dan Liu Jeng-Hun Lee Haomin Chen Eunyoung Kim Xi Shen Qingbin Zheng Jinglei Yang Jang-Kyo Kim | 2021 | Nano-Micro Letters2021，13，8： | 3 |
| 6 | Preparation Porous Monolithic Column and Its Chromatographic Performance显示文摘结合连续加料降低聚合体系的放热量,及强化体系的换热能力等措施,实现了无搅拌模式聚合体系中温度分布的均一化.通过单次聚合过程构造了体积为38 mL的大体积整体固定相.SEM及孔隙率分布测试证明了整体固定相具有均匀的孔结构,动态容量测定及分离蛋白质的实验,表明所制备的径向流动模式整体柱的容量及分辨率不依赖于流速,同时在高流速下具有低背压的特征,可用于生物大分子的分离制备. | Chen Guoliang Zhang Xiaohui Shang Defa Wang Qingbin Yang Changlong Li Tong | 2006 | 分析化学2006，34，10： | 3 |
| 7 | Convergence History of the Songliao and Jiamusi Blocks in the Eastern End of Central Asian Orogenic Belt: Evidence from Detrital Zircons of Late Paleozoic Sedimentary Rocks显示文摘Central Asian Orogenic Belt(CAOB) is one of the largest accretionary orogenic belts in the world. The eastern segment of CAOB is dominated by Paleozoic Paleo Asian Ocean tectonic regime, Mesozoic Paleo-Pacific tectonic regime and Mongolian-Okhotsk tectonic regime. The Songliao and Jiamusi blocks are located in the easternmost part of the CAOB and are the key region to solve the problem about overprinting processes of multiple tectonic regimes. It is generally believed that the Mudanjiang Ocean between the two blocks was finally closed in the Mesozoic, but the Paleozoic magmatism also developed along the Mudanjiang suture zone, while on both sides of the suture zone, there were comparable Paleozoic strata, indicating that the two blocks had converged during the Paleozoic, and the evolution history of the two blocks in the Late Paleozoic remains controversial. The Carboniferous-Permian terrestrial strata mainly developed in Binxian, Wuchang and Tieli on Songliao Block, Baoqing and Mishan on Jiamusi Block. Samples from the Songliao and Jiamusi blocks in the Late Carboniferous-Early Permian and Late Permian are collected for comparative analysis. The LAICP-MS zircon U-Pb dating results show that the maximum depositional age of Middle Permian Tumenling Formation and Late Permian Hongshan Formation in Songliao Block is ~260 Ma, while that of Tatouhe Formation and Carboniferous strata in Jiamusi Block are ~290 Ma and ~300 Ma, respectively, which supports the previous stratigraphic division scheme. The age peaks of ~290-300 Ma, ~400 Ma, ~500 Ma appeared in the Late Carboniferous to Early Permian strata of Jiamusi Block and the Middle Permian strata of Songliao Block. The age peak of ~500 Ma in the Middle Permian strata of Songliao Block may come from the Cambrian basement, Mashan Complex, of Jiamusi Block, while the age peaks of ~420-440 Ma in the Carboniferous strata of Jiamusi Block may come from the Silurian magmatic arc in Zhangguangcai Range in the eastern margin of Songliao Block, reflects the history that they had been potential sources of each other, indicating that they may have combined in the Paleozoic. The Hongshan Formation of Songliao Block in the Late Permian lacks the age peak of ~500 Ma, which indicate that Jiamusi Block was not the provenance of Songliao Block in the Late Permian, that is, there was a palaeogeographic isolation between the two blocks. Combined with the ~210 Ma bimodal volcanic rocks developed along the Mudanjiang suture zone reported previously, we believe that the oceanic basin between the Songliao and Jiamusi blocks should have been connected in Late Permian and reopened during Late Permian to Late Triassic. | CHEN Zhaoxu LIU Yongjiang GUAN Qingbin | 2019 | Acta Geologica Sinica(English Edition)2019，93，5： | 2 |
| 8 | Modulating the function of ABCB1: in vitro and in vivo characterization of sitravatinib, a tyrosine kinase inhibitor显示文摘Background:Overexpression of ATP-binding cassette(ABC)transporter is a major contributor to multidrug resistance(MDR),in which cancer cells acquire resistance to a wide spectrum of chemotherapeutic drugs.In this work,we evaluated the sensitizing effect of sitravatinib,a broad-spectrum tyrosine kinase inhibitor(TKI),on ATP-binding cassette subfamily B member 1(ABCB1)-and ATP-binding cassette subfamily C member 10(ABCC10)-mediated MDR.Methods:MTT assay was conducted to examine cytotoxicity and evaluate the sensitizing effect of sitravatinib at non-toxic concentrations.Tritium-labeled paclitaxel transportation,Western blotting,immunofluorescence analysis,and ATPase assay were carried out to elucidate the mechanism of sitravatinib-induced chemosensitization.The in vitro findings were translated into preclinical evaluation with the establishment of xenograft models.Results:Sitravatinib considerably reversed MDR mediated by ABCB1 and partially antagonized ABCC10-mediated MDR.Our in silico docking simulation analysis indicated that sitravatinib strongly and stably bound to the transmembrane domain of ABCB1 human-mouse chimeric model.Furthermore,sitravatinib inhibited hydrolysis of ATP and synchronously decreased the efflux function of ABCB1.Thus,sitravatinib could considerably enhance the intracellular concentration of anticancer drugs.Interestingly,no significant alterations of both expression level and localization of ABCB1 were observed.More importantly,sitravatinib could remarkably restore the antitumor activity of vincristine in ABCB1-mediated xenograft model without observable toxic effect.Conclusions:The findings in this study suggest that the combination of sitrvatinib and substrate antineoplastic drugs of ABCB1 could attenuate the MDR mediated by the overexpression of ABCB1. | Yuqi Yang Ning Ji Chao-Yun Cai Jing-Quan Wang Zi-Ning Lei Qiu-Xu Teng Zhuo-Xun Wu Qingbin Cui Yihang Pan Zhe-Sheng Chen | 2020 | Cancer Communications2020，40，7： | 2 |
| 9 | On two inequalities for the Hadamard product and the Fan product of matrices 显示文摘 | Liu Qingbin Chen Guoliang | 2009 | Lin Alg Appl2009，431，567： | 1 |
| 10 | A new PM_(2.5)-based CADR method to measure air infiltration rate of buildings显示文摘Air infiltration is an important way to exchange indoor air with outdoors.It significantly impacts energy consumption and air quality of buildings.Fine particles(PM_(2.5))in the outdoor atmosphere environment are a potential natural tracer for the measurement of air infiltration rate,especially in the long term field measurement.In this study,a PM_(2.5)-based method,named as CADR(clean air delivery rate)method,is developed to supplement traditional tracer gas method in order to make routine measurement in realistic environments possible and convenient.An air cleaner is installed indoors to reduce indoor PM_(2.5) concentration.Air infiltration is determined by fitting a model to the decreasing concentration data.Comparison with CO_(2) decay method in four different indoor environments gives a normalized mean error of 19%and a correlation coefficient of 0.80 for this method.This justifies the CADR method as a feasible option to measure air infiltration rate.Although subject to several constraints,the proposed method would facilitate field measurement under realistic conditions by being combined with current tracer gas methods. | Cong Liu Siyu Ji Fengjiao Zhou Qingbin Lin Yiqi Chen Xiaoliang Shao | 2021 | Building Simulation2021，14，3： | 1 |
| 11 | Behavior of concrete in water subjected to dynamic triaxial compression 显示文摘 | CHEN Zhangfusheng HU Y LI Qingbin | 2010 | Journal of Engineering Mechanics ASCE2010，136，3： | 1 |
| 12 | Behavior of concrete in water subjected to dynamic triaxial compression 显示文摘 | Chen Z F S Hu Yu LI Qingbin | 2010 | Journal of Engineering Mechanics2010，136，3： | 1 |
| 13 | Behavior of concrete in water subjected to dynamic triaxial compression 显示文摘 | CHEN Zhangiusheng HU Yu LI Qingbin | 2010 | Journal of Engineering Mechanics2010，136，3： | 1 |
| 14 | Epidemiological and Clinical Features of Patients with Scrub Typhus—Guangzhou City,Guangdong Province,China,2012–2018显示文摘Summary What is already known about this topic?Scrub typhus(ST)causes public health challenges in the“tsutsugamushi triangle”in the Asia-Pacific area greater than 13 million square kilometers,affecting an estimated one million people each year.What is added by this report?A retrospective study based on 4,501 hospitalized patients with ST in Guangzhou City,China,described the epidemiological and clinical characteristics,laboratory findings of ST. | Yuehong Wei Xiugang Guan Shixia Zhou Anran Zhang Qingbin Lu Ziwei Zhou Jinjin Chen Haiyang Zhang Yang Ji Baogui Jiang Yang Yang Zhicong Yang Hao Li Liqun Fang Wei Liu | 2021 | China CDC weekly2021，3，51： | 1 |
| 15 | Growth and Transcriptomics Analysis ofMichelia macclurei Dandy Plantlets with Different LED Quality Treatments显示文摘Michelia macclurei Dandy is a significant tree species that has extensive cultivation for forestry and horticulture purposes in southern China,owing to its economic and practical importance.Light quality influences plantlet growth and development during tissue culture.However,the growth characteristic and molecular regulation of M.macclurei under different light quality conditions are not well understood yet.In this study,we investigated the morphological,chlorophyll content,and transcriptomic responses of M.macclurei plantlets under different light-emitting diode(LED)qualities,including white,blue,and red light.The results showed that blue light significantly increased plant height(21.29%)and leaf number(18.65%),while red light decreased plant height and leaf number by 7.53%and 16.49%,respectively.In addition,the plantlets’chlorophyll content and etiolation rate were significantly reduced by blue and red light quality compared to white light.Compared to white light,blue light had a negative effect,leading to decreased rooting rate(64.28%),root number(72.72%),and root length(75.86%).Conversely,red light had a positive effect,resulting in increased rooting rate(24.99%),root number(109.58%),and root length(72.72%).Transcriptome analysis identified 54 differentially expressed genes(DEGs)in three groups that consisted of blue light vs.white light(BL-vs-WL),red light vs.white light(RL-vs-WL),and red light vs.blue light(RL-vs-BL).Specifically,21,7,and 41 DEGs were identified in the three groups,respectively.The DEGs found in the RL-vs-WL and BL-vs-WL groups were involved in plant hormone signaling,nitrogen metabolism,and phenylpropanoid biosynthesis pathways,which suggests that M.macclurei plantlets adapt to the changes of light quality via modulating gene expression.Overall,our study provides valuable insights for understanding the molecular and morphological responses of M.macclurei plantlets under different light qualities. | Zhaoli Chen Ying Liu Bingshan Zeng Qingbin Jiang Shengkun Wang Xiangyang Li | 2023 | Phyton-International Journal of Experimental Botany2023，92，10： | 0 |
| 16 | Oroclines in the Central Asian Orogenic Belt显示文摘The term’orocline’was first proposed by Carey[1]to describe the structure as’an orogenic system which has been flexed in plane to a horse-shoe or elbow shape’;it usually emphasizes that a previous straight mountain belt or tectonic units have been bended horizontally.Nowadays the orocline has been used to describe any curved mountain belt regardless of its original shape[2]. | Yongjiang Liu Wenjiao Xiao Yongfei Ma Sanzhong Li A.Yu.Peskov Zhaoxu Chen Tong Zhou Qingbin Guan | 2023 | National Science Review2023，10，2： | 0 |
| 17 | Dicalcium silicate-induced mitochondrial dysfunction and autophagy-mediated macrophagic inflammation promotes osteogenic differentiation of BMSCs显示文摘Dicalcium silicate(Ca_(2)SiO_(4),C_(2)S)has osteogenic potential but induces macrophagic inflammation.Mitochondrial function plays a vital role in macrophage polarization and macrophagic inflammation.The mitochondrial function of C_(2)S-treated macrophages is still unclear.This study hypothesized:(i)the C_(2)S modulates mitochondrial function and autophagy in macrophages to regulate macro-phagic inflammation,and(ii)C_(2)S-induced macrophagic inflammation regulates osteogenesis.We used RAW264.7 cells as a model of macrophage.The C_(2)S(75–150μg/ml)extract was used to analyze the macrophagic mitochondrial function and macrophagemediated effect on osteogenic differentiation of mouse bone marrow-derived mesenchymal stem cells(BMSCs).The results showed that C_(2)S extract(150μg/ml)induced TNF-α,IL-1βand IL-6 production in macrophages.C_(2)S extract(150μg/ml)enhanced reactive oxygen species level and intracellular calcium level but reduced mitochondrial membrane potential and ATP production.TEM images showed reduced mitochondrial abundance and altered the mitochondrial morphology in C_(2)S(150μg/ml)-treated macrophages.Protein level expression of PINK1,Parkin,Beclin1 and LC3 was upregulated but TOMM20 was downregulated.mRNA sequencing and KEGG analysis showed that C_(2)S-induced differentially expressed mRNAs in macrophages were mainly distributed in the essential signaling pathways involved in mitochondrial function and autophagy.The conditioned medium from C_(2)S-treated macrophage robustly promoted osteogenic differentiation in BMSCs.In conclusion,our results indicate mitochondrial dysfunction and autophagy as the possible mechanism of C_(2)S-induced macrophagic inflammation.The promotion of osteogenic differentiation of BMSCs by the C_(2)S-induced macrophagic inflammation suggests the potential application of C_(2)S in developing immunomodulatory bone grafts. | Qianting Luo Xingyang Li Wenchao Zhong Wei Cao Mingjing Zhu Antong Wu Wanyi Chen Zhitong Ye Qiao Han Duraipandy Natarajan Janak L.Pathak Qingbin Zhang | 2022 | Regenerative Biomaterials2022，9，1： | 0 |
| 18 | Host-guest inclusion for enhancing anticancer activity of pemetrexed against lung carcinoma and decreasing cytotoxicity to normal cells显示文摘Advanced chemotherapy strategies are in urgent demand for improving anticancer efficacy.Herein,a water-soluble pillar[6]arene(WP6 A)was used to load chemotherapeutic agent pemetrexed(PMX)by forming direct host-guest inclusion,which is beneficial for decreasing cytotoxicity of PMX on BEAS-2 B cells.NMR and florescence titration served to confirm the complexation between WP6 A and ATP with higher affinity[(5.67?0.31)x 10^(5)L/mol],favoring competitive replacement of PMX.Complexation ATP by WP6 A effectively prevented ATP from being hydrolyzed in presence of alkaline phosphatase.The formed host-guest complex was further used to block the efflux pump by cutting off energy source from ATP hydrolysis,which was accompanied with releasing PMX to produce synergistic enhancement of anticancer performance towards A549 cells.This supramolecular strategy would also be extended to other clinical chemotherapeutic agents and it was expected to provide salutary profits for cancer patients. | Junyi Chen Yahan Zhang Yadan Zhang Liang Zhao Longming Chen Yao Chai Zhao Meng Xueshun Jia Qingbin Meng Chunju Li | 2021 | Chinese Chemical Letters2021，32，10： | 0 |
| 19 | Observation on 108 Normal Ophthalmic Arteries in 80 Patients by Digital Subtraction Angiography显示文摘By digital subtraction angiography(DSA), the authors made observations on 108 normal ophthalmic arteries in 80 patients with regard to the origins, courses, branching, morphology and anastomoses of the vessels. The merits and demerits of DSA in observing the ophthalmic artery were discussed. Eye Science 1994; 10: 157- 162. | Dongrun Tang, Guoxiang Song, Shimin Cui, Lingen Chen, Qingbin LiDepartment of Ophthalmology, the Second Affiliated Hospital, Tianjin Medical UniversityTianjin 300211, ChinaDepartment of Neurosurgery, Tianjin Huan Hu Hospital | 1994 | 眼科学报1994，10，3： | 0 |
| 20 | Reversing neuromuscular blocking agent decamethonium by carboxylatopillar[6]arene based on host-guest encapsulation显示文摘Neuromuscular blocking agents(NMBAs)are extensively used during anesthesia to improve surgical conditions by relaxing skeletal muscle movements.Rapid neuromuscular recovery after surgery is desirable to facilitate the recovery of muscle function and prevent residual blockade.Decamethonium(C10)is a classic NMBA,which has been restricted over the past decades ascribed to lack of a suitable antidote in clinic.Herein we used carboxylatopillar[6]arene(CP6A)to reverse neuromuscular blocker effect of C10 through direct host-guest encapsulation.NMR and isothermal titration calorimetry served to confirm the complexation between CP6A and C10 with robust affinity[(1.07±0.14)×10^(7)L/mol].The CP6A was further used as a reversal agent of C10,which facilitated to decrease C10 concentration in mice blood and excrete via urinary clearance,resulting in rapid recovery from muscle relaxation.These favorable outcomes might lead us to suggest that this supramolecular strategy could allow patients to regain lucidity much faster than spontaneous recovery from anesthesia. | Yao Chai Longming Chen Yahan Zhang Liang Zhao Zhao Meng Junyi Chen Chunju Li Qingbin Meng | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员